E2F8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of transcription factors which regulate the expression of genes required for progression through the cell cycle. The encoded protein regulates progression from G1 to S phase by ensuring the nucleus divides at the proper time. Multiple alternatively spliced variants, encoding the same protein, have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)5.63180934
2DNA unwinding involved in DNA replication (GO:0006268)5.38155626
3DNA strand elongation involved in DNA replication (GO:0006271)5.14402950
4telomere maintenance via semi-conservative replication (GO:0032201)5.02721363
5protein localization to chromosome, centromeric region (GO:0071459)5.01724054
6DNA strand elongation (GO:0022616)4.92587799
7DNA replication initiation (GO:0006270)4.80613307
8mitotic sister chromatid segregation (GO:0000070)4.74641400
9DNA replication checkpoint (GO:0000076)4.62130850
10sister chromatid segregation (GO:0000819)4.60963767
11kinetochore organization (GO:0051383)4.56775654
12telomere maintenance via recombination (GO:0000722)4.56017862
13mitotic recombination (GO:0006312)4.53918175
14attachment of spindle microtubules to kinetochore (GO:0008608)4.48951892
15mitotic chromosome condensation (GO:0007076)4.37324417
16regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.37081720
17CENP-A containing nucleosome assembly (GO:0034080)4.05325269
18meiotic chromosome segregation (GO:0045132)3.99306889
19establishment of integrated proviral latency (GO:0075713)3.98478029
20microtubule depolymerization (GO:0007019)3.98377484
21chromatin remodeling at centromere (GO:0031055)3.97679872
22nuclear pore complex assembly (GO:0051292)3.94688164
23nuclear pore organization (GO:0006999)3.93009559
24mitotic nuclear envelope disassembly (GO:0007077)3.91297454
25mitotic sister chromatid cohesion (GO:0007064)3.88186423
26DNA topological change (GO:0006265)3.85610765
27telomere maintenance via telomere lengthening (GO:0010833)3.81069902
28nucleotide-excision repair, DNA gap filling (GO:0006297)3.77674831
29kinetochore assembly (GO:0051382)3.74850488
30DNA replication-independent nucleosome organization (GO:0034724)3.74848756
31DNA replication-independent nucleosome assembly (GO:0006336)3.74848756
32mitotic metaphase plate congression (GO:0007080)3.70353784
33regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.62786238
34protoporphyrinogen IX metabolic process (GO:0046501)3.62271648
35negative regulation of chromosome segregation (GO:0051985)3.57162220
36membrane disassembly (GO:0030397)3.56841745
37nuclear envelope disassembly (GO:0051081)3.56841745
38deoxyribonucleotide biosynthetic process (GO:0009263)3.54393345
39regulation of mitotic spindle organization (GO:0060236)3.53773245
40double-strand break repair via nonhomologous end joining (GO:0006303)3.53109252
41non-recombinational repair (GO:0000726)3.53109252
42DNA duplex unwinding (GO:0032508)3.51282340
43folic acid-containing compound biosynthetic process (GO:0009396)3.50797198
44DNA geometric change (GO:0032392)3.50118622
45DNA replication-dependent nucleosome organization (GO:0034723)3.49730758
46DNA replication-dependent nucleosome assembly (GO:0006335)3.49730758
47metaphase plate congression (GO:0051310)3.48503280
48protoporphyrinogen IX biosynthetic process (GO:0006782)3.47314616
49regulation of histone H3-K9 methylation (GO:0051570)3.45232682
50translesion synthesis (GO:0019985)3.43054082
51negative regulation of mitotic sister chromatid separation (GO:2000816)3.41271645
52negative regulation of sister chromatid segregation (GO:0033046)3.41271645
53negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.41271645
54negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.41271645
55negative regulation of mitotic sister chromatid segregation (GO:0033048)3.41271645
56regulation of mitotic sister chromatid separation (GO:0010965)3.40842229
57regulation of mitotic sister chromatid segregation (GO:0033047)3.40842229
58regulation of sister chromatid segregation (GO:0033045)3.40842229
59protein localization to chromosome (GO:0034502)3.40114377
60establishment of chromosome localization (GO:0051303)3.39507009
61positive regulation of chromosome segregation (GO:0051984)3.39027742
62mitotic spindle checkpoint (GO:0071174)3.38159883
63chromatin assembly or disassembly (GO:0006333)3.34760283
64IMP biosynthetic process (GO:0006188)3.33952214
65spindle assembly checkpoint (GO:0071173)3.31051684
66chromosome segregation (GO:0007059)3.28696471
67regulation of spindle organization (GO:0090224)3.26610836
68mitotic spindle assembly checkpoint (GO:0007094)3.25837177
69histone exchange (GO:0043486)3.22565298
70ribosomal small subunit assembly (GO:0000028)3.21877074
71regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.20809778
72DNA conformation change (GO:0071103)3.18256681
73telomere maintenance (GO:0000723)3.17735860
74positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.17504896
75positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.17504896
76positive regulation of mitotic sister chromatid separation (GO:1901970)3.17504896
77telomere organization (GO:0032200)3.14693625
78pore complex assembly (GO:0046931)3.14557258
79sister chromatid cohesion (GO:0007062)3.11394137
80V(D)J recombination (GO:0033151)3.10071742
81dosage compensation (GO:0007549)3.09475875
82negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.06272539
83maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.04549782
84regulation of centrosome duplication (GO:0010824)3.04391763
85ribosome assembly (GO:0042255)3.03089012
86regulation of double-strand break repair via homologous recombination (GO:0010569)3.03030212
87chromosome organization (GO:0051276)3.02515773
88chromosome condensation (GO:0030261)3.02181367
89mismatch repair (GO:0006298)3.01351583
903-UTR-mediated mRNA stabilization (GO:0070935)3.00330754
91G1/S transition of mitotic cell cycle (GO:0000082)2.99170560
92negative regulation of RNA splicing (GO:0033119)2.99079662
93regulation of centrosome cycle (GO:0046605)2.95763852
94IMP metabolic process (GO:0046040)2.94075289
95regulation of nuclear cell cycle DNA replication (GO:0033262)2.92663226
96postreplication repair (GO:0006301)2.92525925
97ATP-dependent chromatin remodeling (GO:0043044)2.92284571
98DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.92223779
99protein K6-linked ubiquitination (GO:0085020)2.91819335
100* regulation of DNA endoreduplication (GO:0032875)2.89675883
101DNA synthesis involved in DNA repair (GO:0000731)2.88099743
102regulation of chromosome segregation (GO:0051983)2.85344270
103base-excision repair (GO:0006284)2.83204084
104DNA packaging (GO:0006323)2.81471556
105nucleobase biosynthetic process (GO:0046112)2.80349640
106negative regulation of mRNA processing (GO:0050686)2.79974520
107erythrocyte maturation (GO:0043249)2.79962825
108regulation of mitotic metaphase/anaphase transition (GO:0030071)2.76526311
109spindle checkpoint (GO:0031577)2.75373180
110nuclear envelope organization (GO:0006998)2.74166310
111* mitotic cell cycle (GO:0000278)2.73526677
112negative regulation of histone methylation (GO:0031061)2.72896008
113DNA damage response, signal transduction resulting in transcription (GO:0042772)2.72472320
114DNA replication (GO:0006260)2.72208993
115DNA ligation (GO:0006266)2.72166777
116chromatin assembly (GO:0031497)2.71331309
117regulation of centriole replication (GO:0046599)2.70639499
118somatic diversification of immune receptors via somatic mutation (GO:0002566)2.69537332
119somatic hypermutation of immunoglobulin genes (GO:0016446)2.69537332
120regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.69127438
121histone-serine phosphorylation (GO:0035404)2.67049902
122regulation of sister chromatid cohesion (GO:0007063)2.65802360
123deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.65673242
124mitotic G2/M transition checkpoint (GO:0044818)2.64886368
125mitotic DNA integrity checkpoint (GO:0044774)2.64808050

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.84741894
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.43944505
3* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.63764457
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.52155486
5MYC_18555785_ChIP-Seq_MESCs_Mouse2.96856823
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.90471085
7* E2F1_21310950_ChIP-Seq_MCF-7_Human2.39425524
8AR_21909140_ChIP-Seq_LNCAP_Human2.37439977
9MYC_22102868_ChIP-Seq_BL_Human2.32988768
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.13375633
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.05385528
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.03980558
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.02514088
14E2F7_22180533_ChIP-Seq_HELA_Human11.1356534
15* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.98680124
16SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.98023128
17EST1_17652178_ChIP-ChIP_JURKAT_Human1.90298920
18SCL_19346495_ChIP-Seq_HPC-7_Human1.88571026
19NELFA_20434984_ChIP-Seq_ESCs_Mouse1.83361317
20VDR_21846776_ChIP-Seq_THP-1_Human1.82815282
21TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.75828813
22MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.72308233
23XRN2_22483619_ChIP-Seq_HELA_Human1.67760796
24VDR_23849224_ChIP-Seq_CD4+_Human1.66766869
25CREB1_15753290_ChIP-ChIP_HEK293T_Human1.64918367
26ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.62416666
27FOXP3_21729870_ChIP-Seq_TREG_Human1.62245973
28E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.61114118
29MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.60952703
30MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.57157083
31CIITA_25753668_ChIP-Seq_RAJI_Human1.56356164
32SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.55030095
33KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.54354524
34HOXB4_20404135_ChIP-ChIP_EML_Mouse1.52748783
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.52652395
36ETS1_20019798_ChIP-Seq_JURKAT_Human1.52439958
37MYB_21317192_ChIP-Seq_ERMYB_Mouse1.48808318
38MYCN_18555785_ChIP-Seq_MESCs_Mouse1.45819979
39HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.43331165
40CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.43209302
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41437615
42GABP_17652178_ChIP-ChIP_JURKAT_Human1.40329641
43SALL1_21062744_ChIP-ChIP_HESCs_Human1.39306074
44DCP1A_22483619_ChIP-Seq_HELA_Human1.39288179
45SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.38768349
46ERG_20887958_ChIP-Seq_HPC-7_Mouse1.37834786
47JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.37246461
48NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.35525465
49IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.32901555
50* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.32469365
51* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.30056050
52* SPI1_23547873_ChIP-Seq_NB4_Human1.28689941
53KDM5A_27292631_Chip-Seq_BREAST_Human1.28241758
54IRF8_22096565_ChIP-ChIP_GC-B_Human1.28061725
55ELK1_19687146_ChIP-ChIP_HELA_Human1.27920169
56TTF2_22483619_ChIP-Seq_HELA_Human1.25871603
57FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.24961591
58GABP_19822575_ChIP-Seq_HepG2_Human1.24350112
59NANOG_18555785_ChIP-Seq_MESCs_Mouse1.24198230
60PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.23619417
61CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.23396461
62THAP11_20581084_ChIP-Seq_MESCs_Mouse1.23163574
63TP63_19390658_ChIP-ChIP_HaCaT_Human1.22343792
64SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.21915340
65TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.20039487
66GATA1_22383799_ChIP-Seq_G1ME_Mouse1.19981840
67* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19757913
68BRD4_27068464_Chip-Seq_AML-cells_Mouse1.19433792
69POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.17271225
70YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15758001
71ZFX_18555785_ChIP-Seq_MESCs_Mouse1.15015614
72CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.14178184
73GATA1_22025678_ChIP-Seq_K562_Human1.11166386
74HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.11019398
75GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.10866119
76NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.09905606
77MYB_26560356_Chip-Seq_TH2_Human1.09827301
78MYB_26560356_Chip-Seq_TH1_Human1.08437994
79RUNX1_22412390_ChIP-Seq_EML_Mouse1.08284380
80* MAF_26560356_Chip-Seq_TH1_Human1.07857881
81CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.07406857
82UTX_26944678_Chip-Seq_JUKART_Human1.06631045
83VDR_24763502_ChIP-Seq_THP-1_Human1.06425402
84TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.06058221
85FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.04800221
86RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.03666790
87TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00781442
88TFEB_21752829_ChIP-Seq_HELA_Human1.00129496
89GATA2_22383799_ChIP-Seq_G1ME_Mouse0.99782323
90PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98988220
91* TCF7_22412390_ChIP-Seq_EML_Mouse0.98038364
92ESR1_15608294_ChIP-ChIP_MCF-7_Human0.97847560
93STAT4_19710469_ChIP-ChIP_TH1__Mouse0.97080207
94BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.97001971
95IRF8_21731497_ChIP-ChIP_J774_Mouse0.96500940
96STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.94267614
97CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94181435
98ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.93442714
99* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.91807248
100HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.91553513
101POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.90950098
102SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.89827415
103STAT3_1855785_ChIP-Seq_MESCs_Mouse0.88341862
104DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.88108028
105SRF_21415370_ChIP-Seq_HL-1_Mouse0.87618586
106CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.87367835
107SOX17_20123909_ChIP-Seq_XEN_Mouse0.85916867
108* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.85728952
109NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.85510796
110PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.85266754
111YY1_21170310_ChIP-Seq_MESCs_Mouse0.84242441
112STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.84113179
113CHD1_26751641_Chip-Seq_LNCaP_Human0.83073185
114CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.82913733
115BP1_19119308_ChIP-ChIP_Hs578T_Human0.81122126
116MYC_18940864_ChIP-ChIP_HL60_Human0.75856781
117NOTCH1_21737748_ChIP-Seq_TLL_Human0.73866499
118SOX2_18555785_ChIP-Seq_MESCs_Mouse0.72623056
119GATA4_21415370_ChIP-Seq_HL-1_Mouse0.72225957
120RBPJ_22232070_ChIP-Seq_NCS_Mouse0.70535282
121HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.70521376
122NANOG_16153702_ChIP-ChIP_HESCs_Human0.70129652
123CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.69928734
124SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.69896513
125DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.68995023
126NANOG_21062744_ChIP-ChIP_HESCs_Human0.64220442
127TBX5_21415370_ChIP-Seq_HL-1_Mouse0.63796052
128KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.62634019
129ZNF263_19887448_ChIP-Seq_K562_Human0.60927717
130IRF1_19129219_ChIP-ChIP_H3396_Human0.60397429
131CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.59892150

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.47446804
2MP0003693_abnormal_embryo_hatching4.27298447
3MP0003111_abnormal_nucleus_morphology4.12262576
4MP0008057_abnormal_DNA_replication3.74956290
5MP0003077_abnormal_cell_cycle3.51008363
6MP0002396_abnormal_hematopoietic_system3.39945011
7MP0004957_abnormal_blastocyst_morpholog3.23085929
8MP0003656_abnormal_erythrocyte_physiolo2.79103126
9MP0008058_abnormal_DNA_repair2.57121715
10MP0005397_hematopoietic_system_phenotyp2.35293002
11MP0001545_abnormal_hematopoietic_system2.35293002
12MP0010307_abnormal_tumor_latency2.25184007
13MP0004808_abnormal_hematopoietic_stem2.22619076
14MP0008007_abnormal_cellular_replicative2.11544226
15MP0004147_increased_porphyrin_level2.08997522
16MP0000490_abnormal_crypts_of2.06575544
17MP0010352_gastrointestinal_tract_polyps2.06442702
18MP0000350_abnormal_cell_proliferation1.88334642
19MP0002398_abnormal_bone_marrow1.83979095
20MP0000749_muscle_degeneration1.83904035
21MP0003718_maternal_effect1.78968920
22MP0008932_abnormal_embryonic_tissue1.73862244
23MP0006054_spinal_hemorrhage1.70792548
24MP0001730_embryonic_growth_arrest1.68736795
25MP0004233_abnormal_muscle_weight1.67241621
26MP0002009_preneoplasia1.59953146
27MP0002722_abnormal_immune_system1.59893102
28MP0003950_abnormal_plasma_membrane1.58240141
29MP0009278_abnormal_bone_marrow1.58183846
30MP0002019_abnormal_tumor_incidence1.56734434
31MP0005076_abnormal_cell_differentiation1.56229097
32MP0000689_abnormal_spleen_morphology1.55199279
33MP0000703_abnormal_thymus_morphology1.49576924
34MP0003646_muscle_fatigue1.49188949
35MP0001835_abnormal_antigen_presentation1.48119568
36MP0001346_abnormal_lacrimal_gland1.45979373
37MP0004145_abnormal_muscle_electrophysio1.43846738
38MP0009333_abnormal_splenocyte_physiolog1.41678378
39MP0000313_abnormal_cell_death1.41065953
40MP0002429_abnormal_blood_cell1.38385060
41MP0003890_abnormal_embryonic-extraembry1.38145156
42MP0008877_abnormal_DNA_methylation1.37231834
43MP0001672_abnormal_embryogenesis/_devel1.36336039
44MP0005380_embryogenesis_phenotype1.36336039
45MP0000685_abnormal_immune_system1.36213561
46MP0005464_abnormal_platelet_physiology1.35928597
47MP0003763_abnormal_thymus_physiology1.34313046
48MP0003436_decreased_susceptibility_to1.34079017
49MP0001800_abnormal_humoral_immune1.33989147
50MP0002086_abnormal_extraembryonic_tissu1.33611778
51MP0003984_embryonic_growth_retardation1.30196013
52MP0001697_abnormal_embryo_size1.29295339
53MP0003123_paternal_imprinting1.28086476
54MP0004185_abnormal_adipocyte_glucose1.27110246
55MP0000716_abnormal_immune_system1.26819475
56MP0002088_abnormal_embryonic_growth/wei1.26584568
57MP0002080_prenatal_lethality1.25194460
58MP0004197_abnormal_fetal_growth/weight/1.22967335
59MP0002269_muscular_atrophy1.20744194
60MP0003786_premature_aging1.19761884
61MP0000858_altered_metastatic_potential1.18894307
62MP0006036_abnormal_mitochondrial_physio1.18346949
63MP0002452_abnormal_antigen_presenting1.17988986
64MP0002420_abnormal_adaptive_immunity1.17555792
65MP0003567_abnormal_fetal_cardiomyocyte1.16133031
66MP0001819_abnormal_immune_cell1.16087992
67MP0000747_muscle_weakness1.15169478
68MP0000751_myopathy1.11309043
69MP0005174_abnormal_tail_pigmentation1.10473411
70MP0002132_abnormal_respiratory_system1.09446647
71MP0005025_abnormal_response_to1.08745918
72MP0005671_abnormal_response_to1.08699586
73MP0003121_genomic_imprinting1.07896241
74MP0010030_abnormal_orbit_morphology1.07007883
75MP0006035_abnormal_mitochondrial_morpho1.05220246
76MP0001853_heart_inflammation1.04766954
77MP0003303_peritoneal_inflammation1.04350170
78MP0002405_respiratory_system_inflammati1.03521235
79MP0005451_abnormal_body_composition1.03356435
80MP0002723_abnormal_immune_serum1.02256212
81MP0002166_altered_tumor_susceptibility1.01596762
82MP0000465_gastrointestinal_hemorrhage1.00792198
83MP0002095_abnormal_skin_pigmentation0.99778786
84MP0009785_altered_susceptibility_to0.98943688
85MP0002085_abnormal_embryonic_tissue0.98091909
86MP0002419_abnormal_innate_immunity0.97586089
87MP0004264_abnormal_extraembryonic_tissu0.96856594
88MP0004087_abnormal_muscle_fiber0.95389905
89MP0002006_tumorigenesis0.94506156
90MP0005000_abnormal_immune_tolerance0.94256600
91MP0001929_abnormal_gametogenesis0.94175560
92MP0003941_abnormal_skin_development0.93889645
93MP0001661_extended_life_span0.92644662
94MP0003566_abnormal_cell_adhesion0.92594794
95MP0003705_abnormal_hypodermis_morpholog0.91063423
96MP0000759_abnormal_skeletal_muscle0.90970269
97MP0009697_abnormal_copulation0.89775281
98MP0010155_abnormal_intestine_physiology0.89167813
99MP0004036_abnormal_muscle_relaxation0.88689658
100MP0009672_abnormal_birth_weight0.87140703
101MP0002084_abnormal_developmental_patter0.87076518
102MP0004084_abnormal_cardiac_muscle0.86848107
103MP0003806_abnormal_nucleotide_metabolis0.85461647
104MP0003943_abnormal_hepatobiliary_system0.84598099
105MP0005330_cardiomyopathy0.83556681
106MP0003221_abnormal_cardiomyocyte_apopto0.82951577
107MP0001790_abnormal_immune_system0.82791343
108MP0005387_immune_system_phenotype0.82791343
109MP0005075_abnormal_melanosome_morpholog0.82179227
110MP0001915_intracranial_hemorrhage0.80343176
111MP0003300_gastrointestinal_ulcer0.78731743
112MP0003186_abnormal_redox_activity0.77582279
113MP0000358_abnormal_cell_content/0.77121715
114MP0001145_abnormal_male_reproductive0.77030629
115MP0005501_abnormal_skin_physiology0.76829115
116MP0002106_abnormal_muscle_physiology0.76330166
117MP0003937_abnormal_limbs/digits/tail_de0.75733865
118MP0005266_abnormal_metabolism0.74273277
119MP0004947_skin_inflammation0.73699581
120MP0001286_abnormal_eye_development0.73615761
121MP0000733_abnormal_muscle_development0.73442531
122MP0000598_abnormal_liver_morphology0.72909286
123MP0005621_abnormal_cell_physiology0.72726437
124MP0009931_abnormal_skin_appearance0.71920345
125MP0001873_stomach_inflammation0.71761282
126MP0001845_abnormal_inflammatory_respons0.70516964
127MP0000653_abnormal_sex_gland0.69974932
128MP0002160_abnormal_reproductive_system0.69607358
129MP0002877_abnormal_melanocyte_morpholog0.69551925
130MP0002163_abnormal_gland_morphology0.69517553
131MP0005023_abnormal_wound_healing0.69286138
132MP0005384_cellular_phenotype0.68812336
133MP0000477_abnormal_intestine_morphology0.68423267
134MP0003448_altered_tumor_morphology0.67878348
135MP0010234_abnormal_vibrissa_follicle0.67498044
136MP0002210_abnormal_sex_determination0.67014166
137MP0004215_abnormal_myocardial_fiber0.65880897
138MP0003699_abnormal_female_reproductive0.65521925
139MP0010630_abnormal_cardiac_muscle0.65013038
140MP0002970_abnormal_white_adipose0.64361322
141MP0009703_decreased_birth_body0.64171894
142MP0001293_anophthalmia0.64089109
143MP0005369_muscle_phenotype0.63060455
144MP0002697_abnormal_eye_size0.60568024
145MP0001119_abnormal_female_reproductive0.57646160
146MP0005395_other_phenotype0.56096623
147MP0003315_abnormal_perineum_morphology0.55861903
148MP0002111_abnormal_tail_morphology0.55852901
149MP0000428_abnormal_craniofacial_morphol0.54753975
150MP0008995_early_reproductive_senescence0.54193314
151MP0001727_abnormal_embryo_implantation0.50997814

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the heme biosynthetic pathway (HP:0010472)4.57627460
2Chromsome breakage (HP:0040012)4.46392431
3Birth length less than 3rd percentile (HP:0003561)4.44459444
4Chromosomal breakage induced by crosslinking agents (HP:0003221)4.09895075
5Poikilocytosis (HP:0004447)4.02971566
6Muscle fiber inclusion bodies (HP:0100299)3.49720698
7Reticulocytopenia (HP:0001896)3.49459952
8Nemaline bodies (HP:0003798)3.46373714
9Abnormality of chromosome stability (HP:0003220)3.45071696
10Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.44643666
11Nephroblastoma (Wilms tumor) (HP:0002667)3.31472049
12Abnormal number of erythroid precursors (HP:0012131)3.29842172
13Embryonal renal neoplasm (HP:0011794)3.11660828
14Abnormality of cells of the erythroid lineage (HP:0012130)3.11384326
15Myelodysplasia (HP:0002863)3.09019272
16Abnormality of reticulocytes (HP:0004312)3.03417407
17Abnormality of the preputium (HP:0100587)2.95060133
18Petechiae (HP:0000967)2.92585874
19Ectopic kidney (HP:0000086)2.91783296
20Acanthocytosis (HP:0001927)2.91080648
21Volvulus (HP:0002580)2.88538384
22Meckel diverticulum (HP:0002245)2.82868915
23Hypochromic microcytic anemia (HP:0004840)2.81070759
24Reticulocytosis (HP:0001923)2.77518476
25Aplasia/Hypoplasia of the uvula (HP:0010293)2.75709229
26Aplastic anemia (HP:0001915)2.75363393
27Abnormal lung lobation (HP:0002101)2.74644442
28Agnosia (HP:0010524)2.72403027
29Abnormality of the ileum (HP:0001549)2.68754951
30Abnormality of the fingertips (HP:0001211)2.65541443
31Progressive muscle weakness (HP:0003323)2.61993795
32Increased nuchal translucency (HP:0010880)2.60468592
33Prolonged bleeding time (HP:0003010)2.60090149
34Recurrent viral infections (HP:0004429)2.59716558
35High pitched voice (HP:0001620)2.58684002
36Patellar aplasia (HP:0006443)2.57593868
37IgM deficiency (HP:0002850)2.55272154
38Impulsivity (HP:0100710)2.54625933
39Duodenal stenosis (HP:0100867)2.54173211
40Small intestinal stenosis (HP:0012848)2.54173211
41Exercise-induced muscle cramps (HP:0003710)2.51627299
42Absent radius (HP:0003974)2.50992862
43Bone marrow hypocellularity (HP:0005528)2.47341848
44Selective tooth agenesis (HP:0001592)2.42973841
45Thrombocytosis (HP:0001894)2.41160724
46Cellulitis (HP:0100658)2.40648886
47Oral leukoplakia (HP:0002745)2.37580287
48Medulloblastoma (HP:0002885)2.35974570
49Pallor (HP:0000980)2.34756285
50Abnormal platelet volume (HP:0011876)2.34624281
51Clubbing of toes (HP:0100760)2.33695678
52Prominent nose (HP:0000448)2.33505737
53Calcaneovalgus deformity (HP:0001848)2.33081939
54Hypochromic anemia (HP:0001931)2.32844667
55Breast hypoplasia (HP:0003187)2.32062105
56Basal cell carcinoma (HP:0002671)2.31662437
57Aplasia/Hypoplasia of the patella (HP:0006498)2.30911275
58Abnormality of chromosome segregation (HP:0002916)2.30305883
59Abnormality of the labia minora (HP:0012880)2.29831966
60Absent forearm bone (HP:0003953)2.29444778
61Aplasia involving forearm bones (HP:0009822)2.29444778
62Embryonal neoplasm (HP:0002898)2.22363465
63Abnormality of the carotid arteries (HP:0005344)2.21854552
64Abnormality of glycolysis (HP:0004366)2.21659996
65Exercise-induced myalgia (HP:0003738)2.21252624
66Aplasia/Hypoplasia of the sacrum (HP:0008517)2.21168763
67Lymphoma (HP:0002665)2.21135125
68Abnormality of pyrimidine metabolism (HP:0004353)2.20422931
69Acute myeloid leukemia (HP:0004808)2.17224962
70Progressive external ophthalmoplegia (HP:0000590)2.16585502
71Absent thumb (HP:0009777)2.16519437
72Horseshoe kidney (HP:0000085)2.16128804
73Abnormal gallbladder physiology (HP:0012438)2.14981552
74Cholecystitis (HP:0001082)2.14981552
75Cortical dysplasia (HP:0002539)2.13265573
76Hypoplasia of the capital femoral epiphysis (HP:0003090)2.11791555
77Duplicated collecting system (HP:0000081)2.11572325
78Recurrent abscess formation (HP:0002722)2.10982314
79Abnormality of the left ventricular outflow tract (HP:0011103)2.10498646
80Subaortic stenosis (HP:0001682)2.10498646
81Poikiloderma (HP:0001029)2.09353374
82Increased mean platelet volume (HP:0011877)2.08710530
83Microvesicular hepatic steatosis (HP:0001414)2.08248083
84Sloping forehead (HP:0000340)2.08146756
85Choanal atresia (HP:0000453)2.07390438
86Abnormal platelet function (HP:0011869)2.06633822
87Impaired platelet aggregation (HP:0003540)2.06633822
88Cafe-au-lait spot (HP:0000957)2.06351942
89Long eyelashes (HP:0000527)2.05731289
90Short 4th metacarpal (HP:0010044)2.04701949
91Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.04701949
92Abnormality of DNA repair (HP:0003254)2.03116732
93Arteriovenous malformation (HP:0100026)2.02095700
94Abnormality of the duodenum (HP:0002246)2.01895755
95Increased serum pyruvate (HP:0003542)1.99868016
96Triphalangeal thumb (HP:0001199)1.99774709
97Squamous cell carcinoma (HP:0002860)1.99424698
98B lymphocytopenia (HP:0010976)1.99328546
99Abnormality of B cell number (HP:0010975)1.99328546
100Rhabdomyosarcoma (HP:0002859)1.98864185
10111 pairs of ribs (HP:0000878)1.97980283
102Acute lymphatic leukemia (HP:0006721)1.97960163
103Proximal placement of thumb (HP:0009623)1.97935296
104Recurrent fungal infections (HP:0002841)1.96855208
105Colon cancer (HP:0003003)1.96254462
106Overlapping toe (HP:0001845)1.95912577
107Deviation of the thumb (HP:0009603)1.94160628
108Abnormality of the calcaneus (HP:0008364)1.92417692
109Distal arthrogryposis (HP:0005684)1.91833590
110Ependymoma (HP:0002888)1.91821678
111Aplasia/Hypoplasia of the sternum (HP:0006714)1.91433979
112Abnormal number of incisors (HP:0011064)1.90611781
113Cutaneous photosensitivity (HP:0000992)1.90310848
114Abnormality of the renal collecting system (HP:0004742)1.89680855
115Recurrent bacterial skin infections (HP:0005406)1.89667976
116Deformed tarsal bones (HP:0008119)1.89244804
117Amaurosis fugax (HP:0100576)1.88957549
118Aplasia/Hypoplasia of the earlobes (HP:0009906)1.88764397
119Multiple enchondromatosis (HP:0005701)1.87590638
120Microglossia (HP:0000171)1.87588609
121Abnormality of the prostate (HP:0008775)1.86338882
122Epistaxis (HP:0000421)1.85914397
123Glioma (HP:0009733)1.83786809
124Short middle phalanx of the 5th finger (HP:0004220)1.83644524
125Deep philtrum (HP:0002002)1.82996734
126Short thumb (HP:0009778)1.81059526
127Neoplasm of the colon (HP:0100273)1.80600783
128Slender long bone (HP:0003100)1.79058470
129Tracheoesophageal fistula (HP:0002575)1.78207422
130Chronic otitis media (HP:0000389)1.77662731
131Atresia of the external auditory canal (HP:0000413)1.76734112
132Leukopenia (HP:0001882)1.75878489
133Muscle hypertrophy of the lower extremities (HP:0008968)1.74802443
134Meningitis (HP:0001287)1.73565377
135Long clavicles (HP:0000890)1.72366895
136Degeneration of anterior horn cells (HP:0002398)1.71781969
137Abnormality of the anterior horn cell (HP:0006802)1.71781969
138Cellular immunodeficiency (HP:0005374)1.71664397
139Myopathic facies (HP:0002058)1.71272854
140Abnormality of T cell physiology (HP:0011840)1.69699597
141Abnormality of T cells (HP:0002843)1.68795831
142Abnormality of the astrocytes (HP:0100707)1.68372863
143Astrocytoma (HP:0009592)1.68372863
144Aplasia/Hypoplasia of the thymus (HP:0010515)1.68356910
145Pustule (HP:0200039)1.67731402
146Ureteral duplication (HP:0000073)1.67680003
147Facial hemangioma (HP:0000329)1.67485445
148Calf muscle hypertrophy (HP:0008981)1.64998365
149Cystic hygroma (HP:0000476)1.63409672
150Abnormality of placental membranes (HP:0011409)1.60765352
151Amniotic constriction ring (HP:0009775)1.60765352
152Cholelithiasis (HP:0001081)1.59055790
153Abnormality of the umbilical cord (HP:0010881)1.57964711
154Paralysis (HP:0003470)1.54993267
155Absent phalangeal crease (HP:0006109)1.54914658

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.74935395
2NEK23.51141284
3WEE13.08285422
4CDK122.80188020
5NEK12.70784535
6PBK2.52198249
7BUB12.41880665
8EIF2AK12.39977731
9VRK22.21116587
10EEF2K2.17062118
11STK42.10511935
12MAP3K102.07789466
13TTK2.04768733
14STK102.00492205
15BRSK21.95140279
16CDK41.83416837
17MAP4K11.81459399
18SMG11.79525596
19OBSCN1.79062854
20ATR1.78786998
21PLK41.75910159
22ACVR1B1.70917786
23AURKB1.68102743
24CDK71.67655803
25MST41.65916195
26VRK11.63488005
27PLK11.57694926
28SRPK11.54544323
29TLK11.53392565
30TAF11.48008848
31CCNB11.46739715
32BRSK11.45364255
33RPS6KB21.45330322
34PKN21.40156347
35CHEK21.39831621
36PIM11.36522167
37RPS6KA41.34865623
38CDK61.33807560
39MAP3K81.31675081
40BRD41.31595373
41NME21.30357365
42SCYL21.26985842
43ZAK1.20241461
44DYRK31.17375014
45CLK11.16908056
46MKNK11.15661644
47CHEK11.15589223
48BTK1.09967950
49GRK61.02684831
50CDK81.01819209
51TSSK60.99821838
52PLK30.99060692
53STK30.98043492
54NME10.96807209
55TESK20.96227253
56MAP2K30.95293207
57ATM0.95131961
58NUAK10.91585303
59EIF2AK30.91297036
60FLT30.87669921
61IRAK40.87256748
62BLK0.87098176
63PAK40.86416160
64PASK0.85935435
65LATS10.84872144
66MST1R0.83409554
67MKNK20.80408577
68TRIM280.80397539
69MAPK110.78663954
70CDK20.78463572
71KIT0.78025319
72TAOK30.76203056
73JAK30.76146317
74LRRK20.75472227
75AURKA0.75403930
76ERN10.71741300
77PIM20.71106365
78CSF1R0.66726063
79ICK0.66140541
80MARK30.66107201
81SYK0.64825480
82ZAP700.63561015
83TRPM70.62923760
84TYK20.62591610
85PNCK0.62250548
86SIK30.60807415
87EIF2AK20.60479484
88CDK10.60084879
89MELK0.60019144
90KDR0.56798042
91RPS6KA50.55813165
92TEC0.55424220
93STK160.53425711
94TRIB30.52772713
95TGFBR10.52436094
96BMPR1B0.52301048
97LYN0.52066569
98SIK20.50490796
99BRAF0.49180900
100NEK90.48444352
101ALK0.47740955
102CDK90.47394511
103CSNK2A10.46238443
104MAP3K110.42579303
105CHUK0.42001827
106TXK0.41910814
107MTOR0.41591112
108TTN0.41437074
109CSNK2A20.40767257
110PRKCI0.40459139
111TBK10.39496475
112RPS6KA60.39160282
113AKT20.38019583
114RPS6KC10.37766200
115RPS6KL10.37766200
116CDK30.37264787
117MAPKAPK20.35888798
118PRKDC0.35780060
119RAF10.35760170
120YES10.33971927
121PRPF4B0.33002631
122ERBB30.29974882
123MAPK140.28955218
124CSNK1E0.28126960
125MET0.27557549
126CDK180.25546492
127CDK11A0.24946086
128CDK150.24336248
129GSK3B0.23880478
130DMPK0.22896703
131PHKG20.22288988
132PHKG10.22288988
133ERBB40.21237657
134KSR20.20823533
135IRAK30.18740914
136KSR10.17118606
137CDK140.15380647
138DAPK10.13848808

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.53457858
2Mismatch repair_Homo sapiens_hsa034304.34265674
3Homologous recombination_Homo sapiens_hsa034403.34401720
4Base excision repair_Homo sapiens_hsa034103.26759299
5Cell cycle_Homo sapiens_hsa041103.08743072
6One carbon pool by folate_Homo sapiens_hsa006702.85578197
7Spliceosome_Homo sapiens_hsa030402.64175838
8Nucleotide excision repair_Homo sapiens_hsa034202.63029508
9Fanconi anemia pathway_Homo sapiens_hsa034602.54692987
10RNA transport_Homo sapiens_hsa030132.32847348
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.28548354
12Non-homologous end-joining_Homo sapiens_hsa034502.28017445
13Systemic lupus erythematosus_Homo sapiens_hsa053222.21434017
14Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.99875384
15Ribosome_Homo sapiens_hsa030101.97135513
16Pyrimidine metabolism_Homo sapiens_hsa002401.90695409
17Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.79763718
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.73601040
19p53 signaling pathway_Homo sapiens_hsa041151.67823451
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.66528277
21RNA degradation_Homo sapiens_hsa030181.57969945
22mRNA surveillance pathway_Homo sapiens_hsa030151.45353749
23Herpes simplex infection_Homo sapiens_hsa051681.38978591
24RNA polymerase_Homo sapiens_hsa030201.38555178
25Viral carcinogenesis_Homo sapiens_hsa052031.31679226
26Primary immunodeficiency_Homo sapiens_hsa053401.22697276
27Proteasome_Homo sapiens_hsa030501.20428606
28Antigen processing and presentation_Homo sapiens_hsa046121.17962372
29Pyruvate metabolism_Homo sapiens_hsa006201.16213067
30Basal transcription factors_Homo sapiens_hsa030221.14045014
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.08213390
32Hematopoietic cell lineage_Homo sapiens_hsa046401.02132609
33Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.01866307
34Small cell lung cancer_Homo sapiens_hsa052221.01320403
35Measles_Homo sapiens_hsa051621.01190993
36Transcriptional misregulation in cancer_Homo sapiens_hsa052020.99512140
37Epstein-Barr virus infection_Homo sapiens_hsa051690.99331425
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.98837139
39NF-kappa B signaling pathway_Homo sapiens_hsa040640.96009749
40Chronic myeloid leukemia_Homo sapiens_hsa052200.93926238
41Hepatitis B_Homo sapiens_hsa051610.93876057
42Leishmaniasis_Homo sapiens_hsa051400.91583968
43HTLV-I infection_Homo sapiens_hsa051660.91351545
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.87704602
45Pentose phosphate pathway_Homo sapiens_hsa000300.87630421
46Lysine degradation_Homo sapiens_hsa003100.87599207
47MicroRNAs in cancer_Homo sapiens_hsa052060.86637166
48Apoptosis_Homo sapiens_hsa042100.86622606
49Legionellosis_Homo sapiens_hsa051340.84817937
50Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83977444
51Selenocompound metabolism_Homo sapiens_hsa004500.80853852
52Intestinal immune network for IgA production_Homo sapiens_hsa046720.78849810
53B cell receptor signaling pathway_Homo sapiens_hsa046620.75800862
54Purine metabolism_Homo sapiens_hsa002300.75261897
55Drug metabolism - other enzymes_Homo sapiens_hsa009830.74186193
56Propanoate metabolism_Homo sapiens_hsa006400.71983940
57Alcoholism_Homo sapiens_hsa050340.71691784
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71582358
59RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.69442852
60Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68966587
61Non-small cell lung cancer_Homo sapiens_hsa052230.66790107
62Asthma_Homo sapiens_hsa053100.64978246
63Acute myeloid leukemia_Homo sapiens_hsa052210.64510199
64Cyanoamino acid metabolism_Homo sapiens_hsa004600.64428421
65Influenza A_Homo sapiens_hsa051640.62872615
66Protein export_Homo sapiens_hsa030600.60557032
67Pancreatic cancer_Homo sapiens_hsa052120.58720575
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.58405885
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.57564375
70Shigellosis_Homo sapiens_hsa051310.57015015
71Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56934262
72Huntingtons disease_Homo sapiens_hsa050160.56172940
73NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54716174
74Thyroid cancer_Homo sapiens_hsa052160.53729252
75Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.53162125
76Fructose and mannose metabolism_Homo sapiens_hsa000510.53015777
77Biosynthesis of amino acids_Homo sapiens_hsa012300.52397638
78Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.52212576
79Folate biosynthesis_Homo sapiens_hsa007900.51598239
80Vitamin B6 metabolism_Homo sapiens_hsa007500.51373049
81Central carbon metabolism in cancer_Homo sapiens_hsa052300.50481412
82Oocyte meiosis_Homo sapiens_hsa041140.49852193
83Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49320900
84Viral myocarditis_Homo sapiens_hsa054160.48222023
85Sulfur relay system_Homo sapiens_hsa041220.48208604
86Toll-like receptor signaling pathway_Homo sapiens_hsa046200.46763875
87Bladder cancer_Homo sapiens_hsa052190.46332526
88Adherens junction_Homo sapiens_hsa045200.44291733
89Colorectal cancer_Homo sapiens_hsa052100.43193850
90Fatty acid elongation_Homo sapiens_hsa000620.42421517
91Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.42395511
92N-Glycan biosynthesis_Homo sapiens_hsa005100.42387225
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41760481
94Osteoclast differentiation_Homo sapiens_hsa043800.40923606
95Jak-STAT signaling pathway_Homo sapiens_hsa046300.40072781
96Prostate cancer_Homo sapiens_hsa052150.39205521
97TGF-beta signaling pathway_Homo sapiens_hsa043500.39150962
98Toxoplasmosis_Homo sapiens_hsa051450.38455609
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38362995
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.34657892
101Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34507143
102Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.34067371
103Staphylococcus aureus infection_Homo sapiens_hsa051500.32773736
104Malaria_Homo sapiens_hsa051440.31208081
105Notch signaling pathway_Homo sapiens_hsa043300.30889554
106Glutathione metabolism_Homo sapiens_hsa004800.30665516
107Platelet activation_Homo sapiens_hsa046110.30310517
108Pertussis_Homo sapiens_hsa051330.29974541
109Hippo signaling pathway_Homo sapiens_hsa043900.29812418
110Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.29318492
111Steroid biosynthesis_Homo sapiens_hsa001000.28290582
112Tuberculosis_Homo sapiens_hsa051520.27640778
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.27277458
114Renin-angiotensin system_Homo sapiens_hsa046140.26890814
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.26826344
116Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.23599135
117Metabolic pathways_Homo sapiens_hsa011000.23131276
118Carbon metabolism_Homo sapiens_hsa012000.23109694
119Fatty acid metabolism_Homo sapiens_hsa012120.22817096
120TNF signaling pathway_Homo sapiens_hsa046680.21831516
121Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.21118777
122T cell receptor signaling pathway_Homo sapiens_hsa046600.21036292
123Pathways in cancer_Homo sapiens_hsa052000.20712117
124Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.20419754
125Melanoma_Homo sapiens_hsa052180.19946671
126Glioma_Homo sapiens_hsa052140.19925414
127Basal cell carcinoma_Homo sapiens_hsa052170.19893453
128Parkinsons disease_Homo sapiens_hsa050120.19691984
129Endometrial cancer_Homo sapiens_hsa052130.19198109
130Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.18297021
131Thyroid hormone signaling pathway_Homo sapiens_hsa049190.18037454
132Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.17920064
133Arginine and proline metabolism_Homo sapiens_hsa003300.17821653
134Wnt signaling pathway_Homo sapiens_hsa043100.17785851
135Arginine biosynthesis_Homo sapiens_hsa002200.16235852
136Insulin signaling pathway_Homo sapiens_hsa049100.16096007
137Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.15693079
138Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.15408832
139Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.14118867
140Longevity regulating pathway - mammal_Homo sapiens_hsa042110.12436675
141HIF-1 signaling pathway_Homo sapiens_hsa040660.12169865
142Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.11688433

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