E4F1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The zinc finger protein encoded by this gene is one of several cellular transcription factors whose DNA-binding activities are regulated through the action of adenovirus E1A. A 50-kDa amino-terminal product is generated from the full-length protein through proteolytic cleavage. The protein is differentially regulated by E1A-induced phosphorylation. The full-length gene product represses transcription from the E4 promoter in the absence of E1A, while the 50-kDa form acts as a transcriptional activator in its presence. Alternative splicing results in multiple transcripts encoding different proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of skeletal muscle contraction (GO:0014819)9.37572001
2negative regulation of cell aging (GO:0090344)8.83122919
3GDP-mannose metabolic process (GO:0019673)8.64058148
4protein carboxylation (GO:0018214)8.31187733
5peptidyl-glutamic acid carboxylation (GO:0017187)8.31187733
6DNA strand renaturation (GO:0000733)8.24407802
7cellular response to ATP (GO:0071318)8.00872960
8regulation of synapse structural plasticity (GO:0051823)7.84676581
9regulation of cytokine production involved in inflammatory response (GO:1900015)7.40914740
10negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)7.29598871
11adenosine receptor signaling pathway (GO:0001973)7.04238049
12negative regulation of cell killing (GO:0031342)6.97654160
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.97654160
14positive regulation of gamma-delta T cell activation (GO:0046645)6.94392227
15positive thymic T cell selection (GO:0045059)6.91428261
16granulocyte differentiation (GO:0030851)6.44776604
17regulation of gamma-delta T cell differentiation (GO:0045586)6.42876982
18transepithelial transport (GO:0070633)6.29612813
19lens fiber cell differentiation (GO:0070306)6.29298460
20positive T cell selection (GO:0043368)6.14545920
21meiotic chromosome segregation (GO:0045132)6.08238360
22G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)5.98259359
23negative T cell selection (GO:0043383)5.93057556
24negative thymic T cell selection (GO:0045060)5.87518763
25regulation of gamma-delta T cell activation (GO:0046643)5.70596530
26detection of light stimulus involved in sensory perception (GO:0050962)5.50071404
27detection of light stimulus involved in visual perception (GO:0050908)5.50071404
28semaphorin-plexin signaling pathway (GO:0071526)5.43057970
29purinergic nucleotide receptor signaling pathway (GO:0035590)5.34307927
30thymic T cell selection (GO:0045061)5.31129969
31positive regulation of heat generation (GO:0031652)5.09364294
32phosphatidylglycerol biosynthetic process (GO:0006655)5.04305894
33estrogen biosynthetic process (GO:0006703)4.89081537
34negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.86693822
35negative regulation of translation, ncRNA-mediated (GO:0040033)4.86693822
36regulation of translation, ncRNA-mediated (GO:0045974)4.86693822
37proline biosynthetic process (GO:0006561)4.85673557
38positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.82158127
39T cell selection (GO:0045058)4.80833618
40negative regulation of interleukin-8 production (GO:0032717)4.76227433
41positive regulation of protein kinase C signaling (GO:0090037)4.71784043
42regulation of isotype switching to IgG isotypes (GO:0048302)4.70072301
43adenine nucleotide transport (GO:0051503)4.43819558
44leukocyte aggregation (GO:0070486)4.38578800
45sensory perception of taste (GO:0050909)4.37637706
46regulation of phospholipid biosynthetic process (GO:0071071)4.37491098
47response to ATP (GO:0033198)4.37123281
48negative regulation of erythrocyte differentiation (GO:0045647)4.33740431
49T cell migration (GO:0072678)4.29604764
50protein insertion into membrane (GO:0051205)4.27310221
51antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.27221920
52antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.27221920
53sulfur amino acid catabolic process (GO:0000098)4.22523089
54UV protection (GO:0009650)4.18170286
55purine ribonucleotide transport (GO:0015868)4.17749712
56purinergic receptor signaling pathway (GO:0035587)4.11276193
57B cell receptor signaling pathway (GO:0050853)4.07453709
58rRNA methylation (GO:0031167)4.06348788
59sphingomyelin metabolic process (GO:0006684)4.05961089
60type B pancreatic cell proliferation (GO:0044342)4.02978867
61regulation of cell aging (GO:0090342)3.98448174
62rRNA modification (GO:0000154)3.93140303
63G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.89729972
64T cell receptor signaling pathway (GO:0050852)3.88490463
65antigen processing and presentation of endogenous antigen (GO:0019883)3.86899551
66sphingosine metabolic process (GO:0006670)3.85664304
67NIK/NF-kappaB signaling (GO:0038061)3.81712440
68cardiolipin metabolic process (GO:0032048)3.76246628
69endocytic recycling (GO:0032456)3.72309905
70negative regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045736)3.70261146
71folic acid metabolic process (GO:0046655)3.63037875
72ncRNA 3-end processing (GO:0043628)3.62819165
73mitochondrion distribution (GO:0048311)3.61507043
74regulation of B cell receptor signaling pathway (GO:0050855)3.61231906
75proline metabolic process (GO:0006560)3.60913583
76regulation of heat generation (GO:0031650)3.60462795
77response to interleukin-15 (GO:0070672)3.57133697
78peptidyl-glutamic acid modification (GO:0018200)3.56121709
79nucleotide-sugar biosynthetic process (GO:0009226)3.55381431
80antigen receptor-mediated signaling pathway (GO:0050851)3.54148467
81diol metabolic process (GO:0034311)3.53906571
82phosphatidylethanolamine biosynthetic process (GO:0006646)3.53816433
83histone H3-K4 trimethylation (GO:0080182)3.52525152
84negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.51202881
85positive regulation of gene expression, epigenetic (GO:0045815)3.48746179
86positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.46225358
87cell migration in hindbrain (GO:0021535)3.44066897
88histone H4-K5 acetylation (GO:0043981)3.42571342
89histone H4-K8 acetylation (GO:0043982)3.42571342
90purine nucleotide transport (GO:0015865)3.38050362
91antigen processing and presentation via MHC class Ib (GO:0002475)3.37193084
92protein retention in ER lumen (GO:0006621)3.36489062
93regulation of translation in response to stress (GO:0043555)3.36084249
94phosphate ion homeostasis (GO:0055062)3.35675687
95trivalent inorganic anion homeostasis (GO:0072506)3.35675687
96cilium or flagellum-dependent cell motility (GO:0001539)3.33541367
97urinary tract smooth muscle contraction (GO:0014848)3.33138266
98cellular anion homeostasis (GO:0030002)3.31437401
99regulation of histone H3-K27 methylation (GO:0061085)3.27837944
100DNA deamination (GO:0045006)3.27285244
101negative regulation of innate immune response (GO:0045824)3.23720639
102positive regulation of histone deacetylation (GO:0031065)3.22418680
103positive regulation of isotype switching (GO:0045830)3.22058308
104purine deoxyribonucleotide catabolic process (GO:0009155)3.20699941
105viral transcription (GO:0019083)3.20159141
106negative regulation of RNA splicing (GO:0033119)3.12181437
107regulation of B cell differentiation (GO:0045577)3.11161380
108regulation of alpha-beta T cell proliferation (GO:0046640)3.10841188
109positive regulation of granulocyte differentiation (GO:0030854)3.10652382
110folic acid transport (GO:0015884)3.10569241
111regulation of interferon-beta biosynthetic process (GO:0045357)3.09633338
112cellular response to interleukin-15 (GO:0071350)3.09255860
113positive regulation of TOR signaling (GO:0032008)3.09092204
114DNA replication checkpoint (GO:0000076)3.09043740
115phosphatidylethanolamine metabolic process (GO:0046337)3.07298253
116negative regulation of toll-like receptor signaling pathway (GO:0034122)3.06478575
117regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.06280655
118tRNA modification (GO:0006400)3.05946186
119adaptation of signaling pathway (GO:0023058)3.03047094
120interferon-gamma production (GO:0032609)3.02687263
121regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.01801684
122DNA duplex unwinding (GO:0032508)3.01033671
123regulation of isotype switching (GO:0045191)3.00763027
124tolerance induction (GO:0002507)3.00402997
125grooming behavior (GO:0007625)2.99292396
126melanin biosynthetic process (GO:0042438)2.98064704
127histone H3-K4 methylation (GO:0051568)2.97991030
128positive regulation of interleukin-2 production (GO:0032743)2.95366216
129negative regulation of tumor necrosis factor production (GO:0032720)2.94731944
130histone phosphorylation (GO:0016572)2.94239777
131maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.92222215
132translational termination (GO:0006415)2.91910439
133DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.91331879
134histone H4-K16 acetylation (GO:0043984)2.90678835
135phosphate ion transmembrane transport (GO:0035435)2.88174953
136negative regulation of glycoprotein biosynthetic process (GO:0010561)2.87124793
137regulation of protein kinase A signaling (GO:0010738)2.86995115
138base-excision repair, AP site formation (GO:0006285)2.86165886
139regulation of T cell receptor signaling pathway (GO:0050856)2.85881016
140negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.85066378
141modulation by virus of host process (GO:0019054)2.84500192
142DNA geometric change (GO:0032392)2.83399411
143positive regulation of DNA recombination (GO:0045911)2.82662056
144positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.82490369
145oligosaccharide catabolic process (GO:0009313)2.81070477
146ribosomal small subunit assembly (GO:0000028)2.80659713
147sphingolipid catabolic process (GO:0030149)2.79498975
148dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.76329428
149T cell costimulation (GO:0031295)2.75833359
150nucleoside transmembrane transport (GO:1901642)2.74650069
151hematopoietic stem cell differentiation (GO:0060218)2.74162627
152melanin metabolic process (GO:0006582)2.74149491
153positive regulation of megakaryocyte differentiation (GO:0045654)2.73275505
154negative regulation of mRNA processing (GO:0050686)2.72511037
155positive regulation of RNA splicing (GO:0033120)2.72463047
156regulation of response to interferon-gamma (GO:0060330)2.72168054
157lymphocyte costimulation (GO:0031294)2.71913676
158DNA damage response, signal transduction resulting in transcription (GO:0042772)2.71761915
159positive regulation of protein deacetylation (GO:0090312)2.71703446
160regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.71416030
161sphingoid metabolic process (GO:0046519)2.68047868
162positive regulation of alpha-beta T cell proliferation (GO:0046641)2.67727250
163lymphocyte migration (GO:0072676)2.67023667
164heme transport (GO:0015886)2.66947551
165nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.66700002
166T cell homeostasis (GO:0043029)2.65867107
167translational elongation (GO:0006414)2.65469175
168regulation of cholesterol metabolic process (GO:0090181)2.65366429
169regulation of hydrogen peroxide metabolic process (GO:0010310)2.65059945
170regulation of type I interferon-mediated signaling pathway (GO:0060338)2.64139291
171sodium ion export (GO:0071436)2.63937529
172mRNA cleavage (GO:0006379)2.63617267
173regulation of interleukin-2 production (GO:0032663)2.62467255
174membrane tubulation (GO:0097320)2.60826187
175JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.60257281
176negative regulation of T cell receptor signaling pathway (GO:0050860)2.58854642
177regulation of ARF GTPase activity (GO:0032312)2.57431775
178negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.54998762
179regulation of RNA splicing (GO:0043484)2.54885710
180Peyers patch development (GO:0048541)2.54567607
181mucosal-associated lymphoid tissue development (GO:0048537)2.54567607
182regulation of defense response to virus by virus (GO:0050690)2.53673654
183negative regulation of necroptotic process (GO:0060546)2.51445604
184regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.50869514
185entrainment of circadian clock by photoperiod (GO:0043153)2.50359760
186negative regulation of histone methylation (GO:0031061)2.50348896
187positive regulation of B cell differentiation (GO:0045579)2.50054664
188regulation of interleukin-2 biosynthetic process (GO:0045076)2.49412091
189regulation of histone H3-K4 methylation (GO:0051569)2.47827124
190phagocytosis, recognition (GO:0006910)2.47215758
191mannose metabolic process (GO:0006013)2.46903251
192snRNA metabolic process (GO:0016073)2.46140655
193intracellular estrogen receptor signaling pathway (GO:0030520)2.45443356
194maturation of SSU-rRNA (GO:0030490)2.44417382
195peptidyl-lysine trimethylation (GO:0018023)2.44004221
196T cell differentiation (GO:0030217)2.43949858

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_22102868_ChIP-Seq_BL_Human4.25545312
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.51917140
3VDR_21846776_ChIP-Seq_THP-1_Human3.30164907
4TCF7_22412390_ChIP-Seq_EML_Mouse2.55346097
5SCL_19346495_ChIP-Seq_HPC-7_Human2.46932449
6KDM2B_26808549_Chip-Seq_DND41_Human2.46557493
7MAF_26560356_Chip-Seq_TH1_Human2.43496663
8KDM2B_26808549_Chip-Seq_SUP-B15_Human2.43202156
9CIITA_25753668_ChIP-Seq_RAJI_Human2.42531027
10E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.40138745
11UTX_26944678_Chip-Seq_JUKART_Human2.35336086
12KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.29381395
13KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.21994895
14STAT6_21828071_ChIP-Seq_BEAS2B_Human2.21685712
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.18614620
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.15083357
17FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.10320194
18RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.10149373
19ELK3_25401928_ChIP-Seq_HUVEC_Human2.09770804
20LXR_22292898_ChIP-Seq_THP-1_Human2.09736197
21RUNX_20019798_ChIP-Seq_JUKART_Human2.07798978
22EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.06035246
23ERG_21242973_ChIP-ChIP_JURKAT_Human2.00429305
24MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.99632919
25MAF_26560356_Chip-Seq_TH2_Human1.93242968
26MYB_26560356_Chip-Seq_TH2_Human1.90020743
27MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.87266953
28MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.86553884
29CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.83279264
30IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.82252804
31* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.81943954
32TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.80749335
33SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.80305725
34EGR1_19374776_ChIP-ChIP_THP-1_Human1.79760877
35RARB_24833708_ChIP-Seq_LIVER_Mouse1.79487580
36MYB_26560356_Chip-Seq_TH1_Human1.79429446
37THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.78704688
38* CTCF_27219007_Chip-Seq_Bcells_Human1.78553624
39TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78093566
40RARA_24833708_ChIP-Seq_LIVER_Mouse1.76499552
41CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.75625105
42RUNX1_22412390_ChIP-Seq_EML_Mouse1.74426689
43VDR_24763502_ChIP-Seq_THP-1_Human1.74042148
44ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.73728068
45P68_20966046_ChIP-Seq_HELA_Human1.72312265
46SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.67950343
47* FOXP1_21924763_ChIP-Seq_HESCs_Human1.67062768
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.64486677
49E2F7_22180533_ChIP-Seq_HELA_Human1.64460310
50RXRA_24833708_ChIP-Seq_LIVER_Mouse1.64363217
51FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.61403350
52VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.60399940
53CREB1_26743006_Chip-Seq_LNCaP_Human1.59976079
54KDM2B_26808549_Chip-Seq_JURKAT_Human1.59619335
55SPI1_23127762_ChIP-Seq_K562_Human1.59520952
56SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.58421095
57TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.57719974
58TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.57240458
59TP53_22127205_ChIP-Seq_IMR90_Human1.56897832
60* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.55912727
61FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.55004159
62CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.54652872
63THAP11_20581084_ChIP-Seq_MESCs_Mouse1.51547148
64CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.50683257
65GATA1_19941827_ChIP-Seq_MEL_Mouse1.49331322
66ZNF263_19887448_ChIP-Seq_K562_Human1.48386290
67JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.47867638
68SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47569986
69SA1_27219007_Chip-Seq_ERYTHROID_Human1.44814419
70* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.44555714
71STAT4_19710469_ChIP-ChIP_TH1__Mouse1.44529328
72* CTCF_20526341_ChIP-Seq_ESCs_Human1.43648693
73ELF1_20517297_ChIP-Seq_JURKAT_Human1.42048776
74* XRN2_22483619_ChIP-Seq_HELA_Human1.41913212
75SRY_22984422_ChIP-ChIP_TESTIS_Rat1.41516124
76* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.39724695
77RACK7_27058665_Chip-Seq_MCF-7_Human1.38175299
78GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37781352
79CTCF_27219007_Chip-Seq_ERYTHROID_Human1.36898303
80SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.35941018
81MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.34507005
82BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.34400230
83FOXM1_23109430_ChIP-Seq_U2OS_Human1.33408875
84BCOR_27268052_Chip-Seq_Bcells_Human1.33312556
85BCL6_27268052_Chip-Seq_Bcells_Human1.32280925
86RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.30750191
87ETS1_21867929_ChIP-Seq_TH2_Mouse1.26717800
88TP63_19390658_ChIP-ChIP_HaCaT_Human1.26049944
89PU.1_20513432_ChIP-Seq_Bcells_Mouse1.25424731
90IKZF1_21737484_ChIP-ChIP_HCT116_Human1.25160361
91GABP_19822575_ChIP-Seq_HepG2_Human1.25145237
92ATF3_27146783_Chip-Seq_COLON_Human1.24987631
93SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.24947858
94* SMC4_20622854_ChIP-Seq_HELA_Human1.22917763
95PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22765014
96* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.22014844
97FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.21963294
98EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.21377390
99PHF8_20622854_ChIP-Seq_HELA_Human1.21047968
100CTCF_26484167_Chip-Seq_Bcells_Mouse1.20806553
101YY1_22570637_ChIP-Seq_MALME-3M_Human1.19295314
102CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.18947897
103CTCF_21964334_ChIP-Seq_BJAB-B_Human1.17799246
104SPI1_23547873_ChIP-Seq_NB4_Human1.17395257
105NCOR1_26117541_ChIP-Seq_K562_Human1.17015560
106SA1_27219007_Chip-Seq_Bcells_Human1.15399799
107ELF1_17652178_ChIP-ChIP_JURKAT_Human1.14747947
108UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.14683917
109HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.13809973
110FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.11874639
111* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.11481668
112KDM2B_26808549_Chip-Seq_K562_Human1.11347343
113JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.10828011
114STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.10576310
115ETS1_20019798_ChIP-Seq_JURKAT_Human1.09711806
116GATA3_27048872_Chip-Seq_THYMUS_Human1.09663728
117LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.09402683
118E2F1_20622854_ChIP-Seq_HELA_Human1.08019667
119PKCTHETA_26484144_Chip-Seq_BREAST_Human1.07779795
120ZFP281_27345836_Chip-Seq_ESCs_Mouse1.07542531
121CTCF_21964334_Chip-Seq_Bcells_Human1.07253862
122TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.07076092
123TET1_21451524_ChIP-Seq_MESCs_Mouse1.06570698
124P300_27268052_Chip-Seq_Bcells_Human1.06424794
125DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.05614690
126DCP1A_22483619_ChIP-Seq_HELA_Human1.03796468
127* ERA_21632823_ChIP-Seq_H3396_Human1.03633104
128KDM5A_27292631_Chip-Seq_BREAST_Human1.03514082
129PPARA_22158963_ChIP-Seq_LIVER_Mouse1.02112670
130EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.01883545
131SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.01862899
132ZFP281_18757296_ChIP-ChIP_E14_Mouse1.01835649
133* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01309107
134SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.00897902
135POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.00694892
136MYC_18358816_ChIP-ChIP_MESCs_Mouse1.00504618
137NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.00213485
138SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human1.00142635
139UBF1/2_26484160_Chip-Seq_HMECs_Human0.99104418
140CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98930830
141* RUNX1_27514584_Chip-Seq_MCF-7_Human0.98902757
142DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.98286106
143FOXP3_21729870_ChIP-Seq_TREG_Human0.98267442
144TP63_22573176_ChIP-Seq_HFKS_Human0.97932839
145* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.97835526
146GATA1_19941826_ChIP-Seq_K562_Human0.96518181

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation7.35181996
2MP0001986_abnormal_taste_sensitivity5.48073531
3MP0003763_abnormal_thymus_physiology4.13924290
4MP0008875_abnormal_xenobiotic_pharmacok3.56268592
5MP0001661_extended_life_span3.54057290
6MP0003136_yellow_coat_color3.47147925
7MP0005083_abnormal_biliary_tract3.26222242
8MP0005671_abnormal_response_to3.26191721
9MP0000751_myopathy3.17151603
10MP0000685_abnormal_immune_system3.11643458
11MP0002653_abnormal_ependyma_morphology2.73700200
12MP0005330_cardiomyopathy2.54085392
13MP0001188_hyperpigmentation2.40302517
14MP0002398_abnormal_bone_marrow2.38897411
15MP0001800_abnormal_humoral_immune2.37869781
16MP0002234_abnormal_pharynx_morphology2.33273228
17MP0000750_abnormal_muscle_regeneration2.32812327
18MP0008961_abnormal_basal_metabolism2.30178762
19MP0003866_abnormal_defecation2.29578461
20MP0000703_abnormal_thymus_morphology2.16818006
21MP0002420_abnormal_adaptive_immunity2.15146107
22MP0005058_abnormal_lysosome_morphology2.13575962
23MP0002160_abnormal_reproductive_system2.09832705
24MP0001819_abnormal_immune_cell2.08563429
25MP0002396_abnormal_hematopoietic_system2.07461732
26MP0001756_abnormal_urination2.07105170
27MP0002723_abnormal_immune_serum2.07055758
28MP0005387_immune_system_phenotype2.06842234
29MP0001790_abnormal_immune_system2.06842234
30MP0001968_abnormal_touch/_nociception2.05426925
31MP0002722_abnormal_immune_system1.96365533
32MP0000716_abnormal_immune_system1.96190944
33MP0002254_reproductive_system_inflammat1.95290427
34MP0004510_myositis1.92833685
35MP0003705_abnormal_hypodermis_morpholog1.92609926
36MP0004859_abnormal_synaptic_plasticity1.91436154
37MP0000013_abnormal_adipose_tissue1.89913346
38MP0009333_abnormal_splenocyte_physiolog1.89405367
39MP0002405_respiratory_system_inflammati1.86372694
40MP0003111_abnormal_nucleus_morphology1.82125545
41MP0005000_abnormal_immune_tolerance1.80702461
42MP0000689_abnormal_spleen_morphology1.79692348
43MP0004130_abnormal_muscle_cell1.76985390
44MP0003329_amyloid_beta_deposits1.73510451
45MP0002429_abnormal_blood_cell1.68745234
46MP0000015_abnormal_ear_pigmentation1.68425328
47MP0002452_abnormal_antigen_presenting1.66641544
48MP0000003_abnormal_adipose_tissue1.64899803
49MP0000383_abnormal_hair_follicle1.64804804
50MP0004947_skin_inflammation1.62936155
51MP0005410_abnormal_fertilization1.62374071
52MP0008569_lethality_at_weaning1.62314839
53MP0001919_abnormal_reproductive_system1.62057874
54MP0001835_abnormal_antigen_presentation1.62048092
55MP0003283_abnormal_digestive_organ1.61757073
56MP0005025_abnormal_response_to1.60712354
57MP0002822_catalepsy1.58867374
58MP0002736_abnormal_nociception_after1.54265463
59MP0006292_abnormal_olfactory_placode1.50336836
60MP0005423_abnormal_somatic_nervous1.50158993
61MP0000538_abnormal_urinary_bladder1.49533663
62MP0009785_altered_susceptibility_to1.40053158
63MP0003656_abnormal_erythrocyte_physiolo1.38139243
64MP0003183_abnormal_peptide_metabolism1.36984227
65MP0005075_abnormal_melanosome_morpholog1.34086419
66MP0004885_abnormal_endolymph1.32610397
67MP0002638_abnormal_pupillary_reflex1.31555785
68MP0003806_abnormal_nucleotide_metabolis1.30856696
69MP0004808_abnormal_hematopoietic_stem1.29380732
70MP0006082_CNS_inflammation1.22572104
71MP0004145_abnormal_muscle_electrophysio1.22053485
72MP0005332_abnormal_amino_acid1.21050835
73MP0000470_abnormal_stomach_morphology1.17166466
74MP0006072_abnormal_retinal_apoptosis1.16940086
75MP0009278_abnormal_bone_marrow1.16469492
76MP0004381_abnormal_hair_follicle1.15304483
77* MP0003077_abnormal_cell_cycle1.15011549
78MP0005377_hearing/vestibular/ear_phenot1.12615550
79MP0003878_abnormal_ear_physiology1.12615550
80MP0003045_fibrosis1.11647220
81MP0005257_abnormal_intraocular_pressure1.10106978
82MP0003693_abnormal_embryo_hatching1.08884612
83MP0000465_gastrointestinal_hemorrhage1.07624356
84MP0001765_abnormal_ion_homeostasis1.05885485
85MP0001348_abnormal_lacrimal_gland1.05648124
86MP0005310_abnormal_salivary_gland1.05619638
87MP0001853_heart_inflammation1.05429591
88MP0005394_taste/olfaction_phenotype1.03635707
89MP0005499_abnormal_olfactory_system1.03635707
90MP0005174_abnormal_tail_pigmentation1.03128447
91MP0005584_abnormal_enzyme/coenzyme_acti1.02173121
92MP0001958_emphysema1.01579716
93MP0003787_abnormal_imprinting1.01404777
94MP0005464_abnormal_platelet_physiology1.00879645
95MP0001873_stomach_inflammation1.00248530
96MP0002735_abnormal_chemical_nociception0.96686763
97MP0005397_hematopoietic_system_phenotyp0.93702804
98MP0001545_abnormal_hematopoietic_system0.93702804
99MP0002419_abnormal_innate_immunity0.93468374
100MP0004185_abnormal_adipocyte_glucose0.92796565
101MP0008260_abnormal_autophagy0.91957015
102MP0000358_abnormal_cell_content/0.89722310
103* MP0003453_abnormal_keratinocyte_physiol0.89271394
104MP0003448_altered_tumor_morphology0.88911706
105MP0003303_peritoneal_inflammation0.88586941
106MP0003724_increased_susceptibility_to0.87431440
107MP0005375_adipose_tissue_phenotype0.87112224
108MP0003436_decreased_susceptibility_to0.87082030
109MP0005389_reproductive_system_phenotype0.86532842
110MP0002019_abnormal_tumor_incidence0.83054240
111MP0009840_abnormal_foam_cell0.82879840
112MP0003300_gastrointestinal_ulcer0.82861922
113MP0003137_abnormal_impulse_conducting0.82635779
114MP0000604_amyloidosis0.82607732
115MP0003091_abnormal_cell_migration0.81621206
116MP0010155_abnormal_intestine_physiology0.81152961
117MP0001664_abnormal_digestion0.80820602
118MP0001845_abnormal_inflammatory_respons0.80472529
119MP0005551_abnormal_eye_electrophysiolog0.79869464
120MP0002933_joint_inflammation0.79538852
121MP0001851_eye_inflammation0.78781691
122MP0005365_abnormal_bile_salt0.78510143
123MP0009643_abnormal_urine_homeostasis0.76796454
124MP0003635_abnormal_synaptic_transmissio0.75529143
125MP0002249_abnormal_larynx_morphology0.74312857
126MP0008877_abnormal_DNA_methylation0.72295685
127MP0010234_abnormal_vibrissa_follicle0.72100336
128MP0002132_abnormal_respiratory_system0.71403269
129MP0005670_abnormal_white_adipose0.70956772
130MP0004197_abnormal_fetal_growth/weight/0.69804395
131MP0010678_abnormal_skin_adnexa0.69616186
132MP0004957_abnormal_blastocyst_morpholog0.69319620
133MP0005076_abnormal_cell_differentiation0.68930972
134MP0003172_abnormal_lysosome_physiology0.68824133
135MP0008770_decreased_survivor_rate0.68815345
136MP0000955_abnormal_spinal_cord0.68526729
137MP0005451_abnormal_body_composition0.68513290
138MP0001324_abnormal_eye_pigmentation0.68482268
139* MP0000313_abnormal_cell_death0.67720508
140MP0000747_muscle_weakness0.67697570
141MP0004087_abnormal_muscle_fiber0.67578911
142MP0008057_abnormal_DNA_replication0.65915736
143MP0010094_abnormal_chromosome_stability0.64990169
144* MP0009931_abnormal_skin_appearance0.64688495
145MP0000678_abnormal_parathyroid_gland0.64466605
146MP0002909_abnormal_adrenal_gland0.64226868
147MP0008874_decreased_physiological_sensi0.64163940
148MP0004019_abnormal_vitamin_homeostasis0.63443930
149MP0002166_altered_tumor_susceptibility0.62969262
150* MP0000367_abnormal_coat/_hair0.62627318
151MP0008789_abnormal_olfactory_epithelium0.62503757
152MP0009384_cardiac_valve_regurgitation0.62463579
153MP0000490_abnormal_crypts_of0.61846412
154MP0001346_abnormal_lacrimal_gland0.60600325
155MP0005253_abnormal_eye_physiology0.59734631
156MP0003828_pulmonary_edema0.59560561
157MP0000858_altered_metastatic_potential0.58024679
158MP0005621_abnormal_cell_physiology0.57949690
159MP0005409_darkened_coat_color0.57403367
160MP0000467_abnormal_esophagus_morphology0.57310796
161MP0004043_abnormal_pH_regulation0.57168930
162MP0001502_abnormal_circadian_rhythm0.56164304
163MP0005666_abnormal_adipose_tissue0.55317145
164MP0001849_ear_inflammation0.55227825
165MP0001730_embryonic_growth_arrest0.53449264
166MP0000759_abnormal_skeletal_muscle0.53240961
167* MP0005501_abnormal_skin_physiology0.50789975
168MP0001905_abnormal_dopamine_level0.49439238
169MP0002136_abnormal_kidney_physiology0.49132395
170MP0002118_abnormal_lipid_homeostasis0.47870481
171MP0002210_abnormal_sex_determination0.46315659
172MP0004858_abnormal_nervous_system0.46182855

Predicted human phenotypes

RankGene SetZ-score
1Testicular atrophy (HP:0000029)7.47917167
2Rib fusion (HP:0000902)6.27720057
3Mesangial abnormality (HP:0001966)6.09232134
4Dyschromatopsia (HP:0007641)5.84696654
5Attenuation of retinal blood vessels (HP:0007843)5.06296094
6Hemorrhage of the eye (HP:0011885)4.84951616
7Abnormality of the intrinsic pathway (HP:0010989)4.59847091
8Rectal fistula (HP:0100590)4.55443044
9Rectovaginal fistula (HP:0000143)4.55443044
10Joint hemorrhage (HP:0005261)4.52416895
11Annular pancreas (HP:0001734)4.47613591
12Facial hemangioma (HP:0000329)4.41929980
13Panhypogammaglobulinemia (HP:0003139)4.39327276
14Prolonged partial thromboplastin time (HP:0003645)4.38567227
15Vaginal fistula (HP:0004320)4.38270135
16Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.34373243
17Increased hepatocellular lipid droplets (HP:0006565)4.33694548
18Akinesia (HP:0002304)4.32807050
19Intestinal fistula (HP:0100819)4.31416375
20Facial diplegia (HP:0001349)4.23441982
21Popliteal pterygium (HP:0009756)4.14843105
22Lipid accumulation in hepatocytes (HP:0006561)4.11643189
23Turricephaly (HP:0000262)4.10646118
24Renal Fanconi syndrome (HP:0001994)4.09497926
25Choroideremia (HP:0001139)3.98596395
26T lymphocytopenia (HP:0005403)3.98529313
27Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.75430797
28Recurrent fungal infections (HP:0002841)3.70688772
29Aplasia of the musculature (HP:0100854)3.65978678
30Abnormality of T cell number (HP:0011839)3.57097422
31Fetal akinesia sequence (HP:0001989)3.54044863
32Delayed epiphyseal ossification (HP:0002663)3.52159185
33Squamous cell carcinoma (HP:0002860)3.51528568
34Decreased electroretinogram (ERG) amplitude (HP:0000654)3.46961505
35Atrioventricular block (HP:0001678)3.39979863
36Abnormality of the fingertips (HP:0001211)3.39339818
37Nasal polyposis (HP:0100582)3.33292323
38Coronal craniosynostosis (HP:0004440)3.31744985
39Chronic mucocutaneous candidiasis (HP:0002728)3.31008898
40Recurrent cutaneous fungal infections (HP:0011370)3.31008898
41Elevated erythrocyte sedimentation rate (HP:0003565)3.30731491
42Abnormal delayed hypersensitivity skin test (HP:0002963)3.29459909
43Recurrent bronchitis (HP:0002837)3.26538016
44Anteriorly placed anus (HP:0001545)3.24708859
45Chronic otitis media (HP:0000389)3.18097286
46Increased intramyocellular lipid droplets (HP:0012240)3.17545409
47Increased muscle lipid content (HP:0009058)3.16809672
48Hypoalbuminemia (HP:0003073)3.15905855
49Abnormal albumin level (HP:0012116)3.15905855
50Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.15290599
51Decreased central vision (HP:0007663)3.13324137
52Patellar aplasia (HP:0006443)3.01526946
53Agammaglobulinemia (HP:0004432)2.99060625
54Eczematoid dermatitis (HP:0000976)2.98899057
55Abnormality of T cells (HP:0002843)2.97763867
56Abnormality of the costochondral junction (HP:0000919)2.97285898
57Combined immunodeficiency (HP:0005387)2.95883173
58Myotonia (HP:0002486)2.95802791
59Severe combined immunodeficiency (HP:0004430)2.93724486
60Amniotic constriction ring (HP:0009775)2.91936408
61Abnormality of placental membranes (HP:0011409)2.91936408
62Recurrent viral infections (HP:0004429)2.90041168
63Zonular cataract (HP:0010920)2.87873208
64Hyperacusis (HP:0010780)2.85177204
65Neonatal onset (HP:0003623)2.84826053
66IgM deficiency (HP:0002850)2.83489123
67Respiratory difficulties (HP:0002880)2.79768951
68Aplasia/Hypoplasia of the patella (HP:0006498)2.79108402
69Short chin (HP:0000331)2.78871326
70Increased IgE level (HP:0003212)2.78593684
71Thin bony cortex (HP:0002753)2.73806848
72Exertional dyspnea (HP:0002875)2.69362061
73Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.68825874
74Joint stiffness (HP:0001387)2.62537350
75Pustule (HP:0200039)2.61899791
76Neonatal respiratory distress (HP:0002643)2.60542283
77Capillary hemangiomas (HP:0005306)2.59256213
78Cheilitis (HP:0100825)2.57686099
79Enlarged epiphyses (HP:0010580)2.57043400
80Hypophosphatemic rickets (HP:0004912)2.56250812
81Abnormality of the common coagulation pathway (HP:0010990)2.55092571
82Supernumerary nipples (HP:0002558)2.54923717
83Abnormality of the nasal mucosa (HP:0000433)2.53268401
84Thin ribs (HP:0000883)2.53232389
85Thrombocytosis (HP:0001894)2.52572185
86Insomnia (HP:0100785)2.49470689
87Stomatitis (HP:0010280)2.49359335
88Widely patent fontanelles and sutures (HP:0004492)2.48803086
89Prostate neoplasm (HP:0100787)2.46470341
90Myositis (HP:0100614)2.46458593
91Colitis (HP:0002583)2.42283321
92Acute lymphatic leukemia (HP:0006721)2.40181332
93Abnormal number of erythroid precursors (HP:0012131)2.38576949
94Abnormal urine phosphate concentration (HP:0012599)2.36115507
95Chorioretinal atrophy (HP:0000533)2.33199436
9611 pairs of ribs (HP:0000878)2.29735647
97Prominent nose (HP:0000448)2.29084144
98Choanal stenosis (HP:0000452)2.27010150
99Gastrointestinal inflammation (HP:0004386)2.26696467
100Abnormal epiphyseal ossification (HP:0010656)2.24338050
101Inflammation of the large intestine (HP:0002037)2.24171901
102Abnormality of cells of the erythroid lineage (HP:0012130)2.21795532
103Cholelithiasis (HP:0001081)2.21604744
104Abnormality of renal resorption (HP:0011038)2.19703430
105Absent thumb (HP:0009777)2.19442706
106Flat occiput (HP:0005469)2.19099240
107Premature graying of hair (HP:0002216)2.17944407
108Progressive muscle weakness (HP:0003323)2.17863909
109Cellulitis (HP:0100658)2.14783986
110Ankle clonus (HP:0011448)2.13454436
111Meningitis (HP:0001287)2.12132533
112Tented upper lip vermilion (HP:0010804)2.11192998
113Diminished movement (HP:0002374)2.09085517
114IgG deficiency (HP:0004315)2.06933092
115Lymphopenia (HP:0001888)2.06584097
116Aplasia/Hypoplasia involving the musculature (HP:0001460)2.06008637
117Pterygium (HP:0001059)2.05597050
118Abnormality of T cell physiology (HP:0011840)2.05045796
119Abnormality of the endocardium (HP:0004306)2.04826233
120Heart block (HP:0012722)2.04798080
121Ependymoma (HP:0002888)2.01779624
122Congenital stationary night blindness (HP:0007642)2.01747621
123Malignant hyperthermia (HP:0002047)2.01577878
124Abnormal atrioventricular conduction (HP:0005150)2.01010489
125Emphysema (HP:0002097)2.00496801
126Reticulocytopenia (HP:0001896)2.00484496
127Abnormality of mucopolysaccharide metabolism (HP:0011020)1.99976085
128Abnormality of polysaccharide metabolism (HP:0011012)1.99976085
129Abnormality of glycosaminoglycan metabolism (HP:0004371)1.99976085
130Narrow nasal bridge (HP:0000446)1.97624711
131Abnormality of eosinophils (HP:0001879)1.97223568
132Long clavicles (HP:0000890)1.96732753
133Abnormality of the heme biosynthetic pathway (HP:0010472)1.96243472
134Pallor (HP:0000980)1.93021810
135Hemiplegia (HP:0002301)1.92465513
136Epiphyseal stippling (HP:0010655)1.91861571
137Mask-like facies (HP:0000298)1.91705989
138Albinism (HP:0001022)1.89529570
139Granulocytopenia (HP:0001913)1.88758847
140Abnormal gallbladder morphology (HP:0012437)1.87625691
141Short humerus (HP:0005792)1.87536427
142Progressive external ophthalmoplegia (HP:0000590)1.87079150
143Urinary glycosaminoglycan excretion (HP:0003541)1.86421872
144Mucopolysacchariduria (HP:0008155)1.86421872
145Deep palmar crease (HP:0006191)1.85644104
146Increased number of teeth (HP:0011069)1.85564154
147Entropion (HP:0000621)1.85463707
148Centrally nucleated skeletal muscle fibers (HP:0003687)1.85296089
149Abnormality of cells of the lymphoid lineage (HP:0012140)1.84447490
150Spinal canal stenosis (HP:0003416)1.83670096
151Flat cornea (HP:0007720)1.82565045
152Lymphoma (HP:0002665)1.82229906
153Easy fatigability (HP:0003388)1.82180131
154Abnormal number of incisors (HP:0011064)1.80576579
155Hypergammaglobulinemia (HP:0010702)1.79975527
156Poikiloderma (HP:0001029)1.79847793
157Pili torti (HP:0003777)1.79800096
158Mediastinal lymphadenopathy (HP:0100721)1.79609888
159Reduced subcutaneous adipose tissue (HP:0003758)1.78707595
160Papilloma (HP:0012740)1.77514916
161Verrucae (HP:0200043)1.77514916
162Macular degeneration (HP:0000608)1.77235001
163Abnormal rod and cone electroretinograms (HP:0008323)1.77009286
164Cystic hygroma (HP:0000476)1.74749735
165Leukocytosis (HP:0001974)1.74263888
166Myopathic facies (HP:0002058)1.73573922
167Chronic sinusitis (HP:0011109)1.72929004
168Open mouth (HP:0000194)1.72721969
169Birth length less than 3rd percentile (HP:0003561)1.71841422
170Hypoplastic pelvis (HP:0008839)1.70561607
171Diaphragmatic weakness (HP:0009113)1.70456448
172Eosinophilia (HP:0001880)1.68754461
173Neoplasm of the oral cavity (HP:0100649)1.68747512
174Bronchitis (HP:0012387)1.68233968
175Abnormality of homocysteine metabolism (HP:0010919)1.68050668
176Homocystinuria (HP:0002156)1.68050668
177Bowed forearm bones (HP:0003956)1.66996419
178Bowing of the arm (HP:0006488)1.66996419
179Bony spicule pigmentary retinopathy (HP:0007737)1.66850489
180Ulnar bowing (HP:0003031)1.64207460
181Broad palm (HP:0001169)1.63749472
182Abnormality of chromosome segregation (HP:0002916)1.63558072
183Truncal ataxia (HP:0002078)1.62353796
184Basal cell carcinoma (HP:0002671)1.60484262
185Overriding aorta (HP:0002623)1.59491418
186Recurrent abscess formation (HP:0002722)1.59248410
187Increased IgM level (HP:0003496)1.58594330
188Retrobulbar optic neuritis (HP:0100654)1.58031240
189Optic neuritis (HP:0100653)1.58031240
190Large eyes (HP:0001090)1.56477954

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.54339878
2WNK43.66209866
3MUSK3.53441211
4SRPK13.41083089
5MAP3K102.99735212
6TLK12.75915775
7TXK2.56339532
8SIK22.50662200
9EPHA32.31399999
10TYK22.27636743
11SIK12.17855264
12EEF2K2.16927015
13ZAP701.97342498
14GRK61.95595142
15STK101.91143471
16FGFR41.82239225
17TSSK61.79093262
18MAPK151.76754566
19MAP3K131.71130899
20PRPF4B1.65874327
21ITK1.55529953
22TRIB31.54570437
23MAP2K61.49452180
24DAPK21.49079515
25PDPK11.47817829
26BMX1.41111884
27IRAK21.41106488
28MARK21.38404588
29HIPK21.37097358
30KIT1.36316305
31EPHB11.35622446
32CCNB11.35075196
33PDK21.33812646
34BTK1.33101049
35SMG11.29854409
36CSF1R1.28012384
37SCYL21.26921490
38JAK11.24641701
39ERN11.19969392
40TAOK21.18531825
41LCK1.18070378
42BUB11.15694805
43HCK1.15571161
44TESK21.15390342
45PIM21.13980246
46BRD41.12809470
47TAOK11.12222662
48BLK1.05963705
49NLK1.05508835
50FES1.05075614
51CDK61.03717168
52SYK1.03263474
53KSR21.00744277
54PTK61.00561268
55CSK0.99694734
56NEK20.99254679
57JAK30.96746293
58ZAK0.96103320
59MAP3K70.94902129
60TYRO30.94688527
61JAK20.93747901
62PAK10.92852512
63UHMK10.92691009
64PRKCH0.92226330
65IKBKE0.91877839
66AURKA0.89338830
67PRKD20.88934266
68CDK150.88372060
69TBK10.87698241
70IRAK40.87221741
71MAP3K80.86321714
72CDK11A0.85485402
73CDK120.84127353
74ALK0.83592745
75WNK10.83353776
76IRAK30.82091123
77PRKD30.80547607
78CDK180.80054642
79TTN0.79152349
80RPS6KC10.76714824
81RPS6KL10.76714824
82ADRBK10.74050145
83MAP3K110.73834448
84IKBKB0.73765694
85ARAF0.73538989
86BCKDK0.73420502
87RPS6KA60.73304555
88CLK10.71755181
89TNK20.71366937
90PAK40.65553989
91EPHA20.64482715
92MAPK110.64379889
93MAP3K10.60696177
94NTRK20.60252761
95MAP2K30.59501198
96DMPK0.59078020
97MST1R0.58393030
98CDK140.58341557
99ROCK20.57903529
100PAK60.55554847
101ICK0.55515885
102DYRK1A0.55399087
103MAP2K20.55044334
104NME20.54178996
105MTOR0.54162672
106CAMK1G0.53094557
107ACVR1B0.52177385
108SIK30.52128272
109ATR0.51759750
110STK160.50607818
111CSNK1A1L0.50167523
112CHUK0.49562661
113DYRK1B0.48800157
114CDC42BPA0.47803688
115CSNK1G30.47006927
116RPS6KA50.45553727
117CHEK20.45410714
118FGFR30.45215077
119CSNK1G10.44024687
120MAPK120.43871490
121MAPK80.43734228
122STK110.42772541
123CAMK40.42765284
124CDK40.41644330
125RPS6KA20.41355658
126NTRK30.41277175
127LYN0.40906637
128MATK0.40804258
129PKN20.40191070
130DYRK30.39563541
131PNCK0.38397819
132RIPK10.38072702
133PRKAA10.37552060
134CAMK10.37036894
135PRKD10.36802752
136RAF10.34963485
137MELK0.33616181
138AKT20.31454300
139PDK10.31404039
140TRIM280.30822056
141ADRBK20.29822276
142CAMKK10.29553445
143PRKCI0.29302506
144CDK10.27005264
145RPS6KA10.26672740
146RIPK40.25392391
147CDK20.22359652
148BRAF0.22299582
149MAPK30.20958261
150PLK10.20831122
151MAP3K30.18585721

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001307.50691124
2Sulfur relay system_Homo sapiens_hsa041224.99366316
3Primary immunodeficiency_Homo sapiens_hsa053404.30031759
4Glycosaminoglycan degradation_Homo sapiens_hsa005313.68908453
5Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.46144553
6Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.09446331
7Fructose and mannose metabolism_Homo sapiens_hsa000512.79131002
8T cell receptor signaling pathway_Homo sapiens_hsa046602.60892262
9Other glycan degradation_Homo sapiens_hsa005112.40235032
10Sphingolipid metabolism_Homo sapiens_hsa006002.39499373
11B cell receptor signaling pathway_Homo sapiens_hsa046622.38487178
12Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.25294728
13Antigen processing and presentation_Homo sapiens_hsa046122.21789798
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.94272127
15Ribosome_Homo sapiens_hsa030101.78705400
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.69684169
17Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.65444746
18Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.64176752
19Vitamin B6 metabolism_Homo sapiens_hsa007501.63124339
20Acute myeloid leukemia_Homo sapiens_hsa052211.56532754
21Osteoclast differentiation_Homo sapiens_hsa043801.41352200
22Spliceosome_Homo sapiens_hsa030401.40348839
23Notch signaling pathway_Homo sapiens_hsa043301.37964766
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.37405366
25Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.33514885
26Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.29246508
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.25561495
28Hematopoietic cell lineage_Homo sapiens_hsa046401.25102747
29Measles_Homo sapiens_hsa051621.19597452
30Lysosome_Homo sapiens_hsa041421.19156103
31Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.17087474
32Phosphatidylinositol signaling system_Homo sapiens_hsa040701.16474102
33Non-small cell lung cancer_Homo sapiens_hsa052231.15800052
34HTLV-I infection_Homo sapiens_hsa051661.15156643
35DNA replication_Homo sapiens_hsa030301.13908692
36Chronic myeloid leukemia_Homo sapiens_hsa052201.13532406
37Jak-STAT signaling pathway_Homo sapiens_hsa046301.11509055
38VEGF signaling pathway_Homo sapiens_hsa043701.09845134
39Circadian rhythm_Homo sapiens_hsa047101.08425285
40mRNA surveillance pathway_Homo sapiens_hsa030151.08160772
41Neurotrophin signaling pathway_Homo sapiens_hsa047221.04704268
42Intestinal immune network for IgA production_Homo sapiens_hsa046721.02055071
43Herpes simplex infection_Homo sapiens_hsa051681.01286892
44Chemokine signaling pathway_Homo sapiens_hsa040620.99672802
45Glycerophospholipid metabolism_Homo sapiens_hsa005640.98540166
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.97761385
47RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.95160093
48Pancreatic cancer_Homo sapiens_hsa052120.89346085
49Choline metabolism in cancer_Homo sapiens_hsa052310.89237502
50Inositol phosphate metabolism_Homo sapiens_hsa005620.88841933
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88252395
52Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.86402204
53Epstein-Barr virus infection_Homo sapiens_hsa051690.85336562
54mTOR signaling pathway_Homo sapiens_hsa041500.84481060
55Thyroid hormone signaling pathway_Homo sapiens_hsa049190.83990947
56Long-term potentiation_Homo sapiens_hsa047200.83942482
57Cocaine addiction_Homo sapiens_hsa050300.83916248
58Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.82471228
59Base excision repair_Homo sapiens_hsa034100.82421314
60Phospholipase D signaling pathway_Homo sapiens_hsa040720.81202305
61Synaptic vesicle cycle_Homo sapiens_hsa047210.79966523
62Axon guidance_Homo sapiens_hsa043600.78675046
63Cell cycle_Homo sapiens_hsa041100.77580122
64Ovarian steroidogenesis_Homo sapiens_hsa049130.76867295
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76380106
66Aldosterone synthesis and secretion_Homo sapiens_hsa049250.76278117
67Hepatitis B_Homo sapiens_hsa051610.76276152
68RNA polymerase_Homo sapiens_hsa030200.75408649
69Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.74532752
70Endocytosis_Homo sapiens_hsa041440.72703710
71Non-homologous end-joining_Homo sapiens_hsa034500.72546918
72Apoptosis_Homo sapiens_hsa042100.72131198
73Colorectal cancer_Homo sapiens_hsa052100.71891311
74Leukocyte transendothelial migration_Homo sapiens_hsa046700.71834422
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71597398
76ErbB signaling pathway_Homo sapiens_hsa040120.70547820
77Type II diabetes mellitus_Homo sapiens_hsa049300.68899944
78MAPK signaling pathway_Homo sapiens_hsa040100.68709678
79Taste transduction_Homo sapiens_hsa047420.68611635
80Platelet activation_Homo sapiens_hsa046110.68271917
81Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.67866332
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67322117
83Oxytocin signaling pathway_Homo sapiens_hsa049210.66557762
84Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.66231611
85Vitamin digestion and absorption_Homo sapiens_hsa049770.65653963
86Toxoplasmosis_Homo sapiens_hsa051450.65583735
87Renal cell carcinoma_Homo sapiens_hsa052110.65398495
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64146878
89Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.63515024
90Insulin resistance_Homo sapiens_hsa049310.63172226
91Basal cell carcinoma_Homo sapiens_hsa052170.62686648
92Viral carcinogenesis_Homo sapiens_hsa052030.61768505
93Prolactin signaling pathway_Homo sapiens_hsa049170.61542630
94Oocyte meiosis_Homo sapiens_hsa041140.60749956
95Lysine degradation_Homo sapiens_hsa003100.60657367
96Morphine addiction_Homo sapiens_hsa050320.60466357
97N-Glycan biosynthesis_Homo sapiens_hsa005100.60172092
98Leishmaniasis_Homo sapiens_hsa051400.59973744
99Estrogen signaling pathway_Homo sapiens_hsa049150.59344680
100Amphetamine addiction_Homo sapiens_hsa050310.58712204
101Influenza A_Homo sapiens_hsa051640.55340232
102Salivary secretion_Homo sapiens_hsa049700.55064114
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.54915941
104Biosynthesis of amino acids_Homo sapiens_hsa012300.54864336
105cAMP signaling pathway_Homo sapiens_hsa040240.54153245
106Wnt signaling pathway_Homo sapiens_hsa043100.51883969
107Alcoholism_Homo sapiens_hsa050340.51780569
108Graft-versus-host disease_Homo sapiens_hsa053320.51448324
109Bladder cancer_Homo sapiens_hsa052190.51359378
110Shigellosis_Homo sapiens_hsa051310.51174841
111Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.50951330
112Phototransduction_Homo sapiens_hsa047440.50653386
113Regulation of autophagy_Homo sapiens_hsa041400.49914220
114Glutathione metabolism_Homo sapiens_hsa004800.49891395
115Glutamatergic synapse_Homo sapiens_hsa047240.49518846
116RNA transport_Homo sapiens_hsa030130.48017336
117Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.47907871
118GnRH signaling pathway_Homo sapiens_hsa049120.47839532
119Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.47317502
120cGMP-PKG signaling pathway_Homo sapiens_hsa040220.46623331
121Fanconi anemia pathway_Homo sapiens_hsa034600.46272669
122Calcium signaling pathway_Homo sapiens_hsa040200.45445093
123Hepatitis C_Homo sapiens_hsa051600.45321442
124p53 signaling pathway_Homo sapiens_hsa041150.45289164
125Hedgehog signaling pathway_Homo sapiens_hsa043400.44666349
126Pyrimidine metabolism_Homo sapiens_hsa002400.41132983
127Cyanoamino acid metabolism_Homo sapiens_hsa004600.40688547
128Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.39446017
129Toll-like receptor signaling pathway_Homo sapiens_hsa046200.39262213
130Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39012880
131Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37150130
132Melanogenesis_Homo sapiens_hsa049160.35296315
133Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.33049159
134Galactose metabolism_Homo sapiens_hsa000520.32081649
135NOD-like receptor signaling pathway_Homo sapiens_hsa046210.31537100
136Hippo signaling pathway_Homo sapiens_hsa043900.30138704
137TNF signaling pathway_Homo sapiens_hsa046680.27122789
138Pyruvate metabolism_Homo sapiens_hsa006200.26663116
139Insulin signaling pathway_Homo sapiens_hsa049100.25797640
140Basal transcription factors_Homo sapiens_hsa030220.25510139
141Arginine biosynthesis_Homo sapiens_hsa002200.23878315
142AMPK signaling pathway_Homo sapiens_hsa041520.22690587
143Tuberculosis_Homo sapiens_hsa051520.22311230
144Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.16599564
145Systemic lupus erythematosus_Homo sapiens_hsa053220.16011271
146Metabolic pathways_Homo sapiens_hsa011000.15718898
147Endometrial cancer_Homo sapiens_hsa052130.15623634
148Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.14973089
149Sphingolipid signaling pathway_Homo sapiens_hsa040710.14398299
150PPAR signaling pathway_Homo sapiens_hsa033200.11917802
151Gap junction_Homo sapiens_hsa045400.11149230
152Glycerolipid metabolism_Homo sapiens_hsa005610.10191196

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