EAF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cornea development in camera-type eye (GO:0061303)6.65060934
2keratinocyte development (GO:0003334)5.93828269
3regulation of hexokinase activity (GO:1903299)5.39926402
4regulation of glucokinase activity (GO:0033131)5.39926402
5lactate metabolic process (GO:0006089)4.57618949
6dorsal/ventral axis specification (GO:0009950)4.28558144
7folic acid-containing compound biosynthetic process (GO:0009396)4.08626790
8DNA double-strand break processing (GO:0000729)4.08427995
9regulation of timing of cell differentiation (GO:0048505)3.93879575
10low-density lipoprotein particle clearance (GO:0034383)3.90725520
11negative regulation of translation, ncRNA-mediated (GO:0040033)3.84817155
12regulation of translation, ncRNA-mediated (GO:0045974)3.84817155
13negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.84817155
14hindbrain development (GO:0030902)3.66674679
15intestinal epithelial cell development (GO:0060576)3.66669342
16positive regulation of glycolytic process (GO:0045821)3.64479825
17positive regulation of protein autophosphorylation (GO:0031954)3.62213787
18positive regulation of glycoprotein biosynthetic process (GO:0010560)3.48798481
19Golgi transport vesicle coating (GO:0048200)3.43612866
20COPI coating of Golgi vesicle (GO:0048205)3.43612866
21regulation of development, heterochronic (GO:0040034)3.42804439
22regulation of B cell apoptotic process (GO:0002902)3.35564059
23L-alpha-amino acid transmembrane transport (GO:1902475)3.34284939
24negative regulation of neurological system process (GO:0031645)3.33902343
25synapsis (GO:0007129)3.33040500
26inositol phosphate catabolic process (GO:0071545)3.25331419
27positive regulation of cell fate commitment (GO:0010455)3.24962080
28astrocyte differentiation (GO:0048708)3.24586775
29glial cell proliferation (GO:0014009)3.18536875
30water-soluble vitamin biosynthetic process (GO:0042364)3.18497686
31platelet dense granule organization (GO:0060155)3.12850280
32positive regulation of glycoprotein metabolic process (GO:1903020)3.11777214
33RNA destabilization (GO:0050779)3.07715999
34protein prenylation (GO:0018342)3.07057818
35prenylation (GO:0097354)3.07057818
36negative regulation of dendrite morphogenesis (GO:0050774)3.04381196
37prostate gland growth (GO:0060736)3.04289140
38natural killer cell mediated immunity (GO:0002228)3.01870016
39natural killer cell mediated cytotoxicity (GO:0042267)3.01870016
40protein targeting to Golgi (GO:0000042)3.01523812
41modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.99712693
42positive regulation by organism of defense response of other organism involved in symbiotic interact2.99712693
43modulation by symbiont of host immune response (GO:0052553)2.99712693
44positive regulation by symbiont of host defense response (GO:0052509)2.99712693
45modulation by symbiont of host defense response (GO:0052031)2.99712693
46modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.99712693
47polyol catabolic process (GO:0046174)2.98480079
48response to pheromone (GO:0019236)2.97771220
49activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.96799038
50pancreas development (GO:0031016)2.95445508
51positive regulation of nuclease activity (GO:0032075)2.95285647
52indole-containing compound catabolic process (GO:0042436)2.95094341
53indolalkylamine catabolic process (GO:0046218)2.95094341
54tryptophan catabolic process (GO:0006569)2.95094341
55negative regulation of DNA-dependent DNA replication (GO:2000104)2.94338217
56protein K11-linked deubiquitination (GO:0035871)2.91503351
57heterochromatin organization (GO:0070828)2.90715074
58signal peptide processing (GO:0006465)2.89472065
59establishment of protein localization to Golgi (GO:0072600)2.87142984
60negative regulation of dendrite development (GO:2000171)2.85514884
61tetrahydrofolate metabolic process (GO:0046653)2.84574937
62positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.84049214
63regulation of translational fidelity (GO:0006450)2.84035813
64ER overload response (GO:0006983)2.83574915
65cell adhesion mediated by integrin (GO:0033627)2.80784291
66positive regulation of macroautophagy (GO:0016239)2.80124644
67UDP-N-acetylglucosamine metabolic process (GO:0006047)2.78710485
68regulation of nuclease activity (GO:0032069)2.77879397
69endoplasmic reticulum unfolded protein response (GO:0030968)2.77157508
70regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.76413889
71insulin secretion (GO:0030073)2.76135887
72glandular epithelial cell differentiation (GO:0002067)2.75576222
73somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.74826131
74somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.74826131
75isotype switching (GO:0045190)2.74826131
76regulation of translational termination (GO:0006449)2.74371023
77pre-miRNA processing (GO:0031054)2.74102914
78replication fork processing (GO:0031297)2.73042043
79regulation of cholesterol storage (GO:0010885)2.72439063
80histone H2A acetylation (GO:0043968)2.72337419
81DNA deamination (GO:0045006)2.70719662
82atrial cardiac muscle cell action potential (GO:0086014)2.70398126
83cellular response to unfolded protein (GO:0034620)2.70160083
84regulation of protein autophosphorylation (GO:0031952)2.69554408
85regulation of meiosis I (GO:0060631)2.68308755
86histone mRNA catabolic process (GO:0071044)2.68135747
87nuclear pore complex assembly (GO:0051292)2.68010386
88positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.67372652
89regulation of type B pancreatic cell apoptotic process (GO:2000674)2.66607458
90signal transduction involved in regulation of gene expression (GO:0023019)2.66577468
91zinc ion transport (GO:0006829)2.66070214
92respiratory chain complex IV assembly (GO:0008535)2.66016776
93negative regulation of acute inflammatory response (GO:0002674)2.64536973
94proteasome assembly (GO:0043248)2.63873793
95apoptotic cell clearance (GO:0043277)2.63782907
96phosphorylated carbohydrate dephosphorylation (GO:0046838)2.63230396
97inositol phosphate dephosphorylation (GO:0046855)2.63230396
98glandular epithelial cell development (GO:0002068)2.62901208
99columnar/cuboidal epithelial cell development (GO:0002066)2.62632929
100histone H2A ubiquitination (GO:0033522)2.61992550
101positive regulation of mitotic sister chromatid separation (GO:1901970)2.61813618
102positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.61813618
103positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.61813618
104positive regulation of response to nutrient levels (GO:0032109)2.61730810
105positive regulation of response to extracellular stimulus (GO:0032106)2.61730810
106retrograde transport, vesicle recycling within Golgi (GO:0000301)2.61644364
107negative regulation of execution phase of apoptosis (GO:1900118)2.61607173
108regulation of Rac protein signal transduction (GO:0035020)2.59875201
109single strand break repair (GO:0000012)2.59447283
110nuclear pore organization (GO:0006999)2.58617043
111kynurenine metabolic process (GO:0070189)2.57459554
112antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.57260740
113antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.57260740
114parental behavior (GO:0060746)2.57094602
115positive regulation of neuroblast proliferation (GO:0002052)2.56662113
116positive regulation of histone deacetylation (GO:0031065)2.55030774
117protein localization to endosome (GO:0036010)2.55023239
118ER-nucleus signaling pathway (GO:0006984)2.54663859
119COPII vesicle coating (GO:0048208)2.54355339
120positive regulation of p38MAPK cascade (GO:1900745)2.54176586
121regulation of cholesterol homeostasis (GO:2000188)2.52990954
122pentose-phosphate shunt (GO:0006098)2.52075576
123cytochrome complex assembly (GO:0017004)2.49927174
124cellular response to arsenic-containing substance (GO:0071243)2.49694858
125response to arsenic-containing substance (GO:0046685)2.49664038
126mRNA stabilization (GO:0048255)2.49275706
127RNA stabilization (GO:0043489)2.49275706
128plasma lipoprotein particle clearance (GO:0034381)2.48765682
129protein localization to cilium (GO:0061512)2.47144770
130endocrine pancreas development (GO:0031018)2.46763242
131regulation of membrane protein ectodomain proteolysis (GO:0051043)2.46332186
132regulation of protein glycosylation (GO:0060049)2.46159176
133cellular response to topologically incorrect protein (GO:0035967)2.45997956
134gastrulation with mouth forming second (GO:0001702)2.43883056
135regulation of sulfur metabolic process (GO:0042762)2.43060924
136negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.41640043
137hepatocyte apoptotic process (GO:0097284)2.40798308
138protein localization to kinetochore (GO:0034501)2.40541702
139neural tube formation (GO:0001841)2.40254543
140response to laminar fluid shear stress (GO:0034616)2.39476024
141embryonic foregut morphogenesis (GO:0048617)2.37330156
142regulation of podosome assembly (GO:0071801)2.37236786
143cell wall macromolecule catabolic process (GO:0016998)2.37103578
144kidney morphogenesis (GO:0060993)2.36753505
145response to lipoprotein particle (GO:0055094)2.36668240
146regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.36588350
147cilium morphogenesis (GO:0060271)2.35256819
148negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.35196361
1494-hydroxyproline metabolic process (GO:0019471)2.34470399
150T cell apoptotic process (GO:0070231)2.33463416
151maternal placenta development (GO:0001893)2.32098783
152response to UV-C (GO:0010225)2.31790805
153cysteine metabolic process (GO:0006534)2.31229625
154negative regulation of fibrinolysis (GO:0051918)2.31016365
155positive regulation of SMAD protein import into nucleus (GO:0060391)2.30260756
156wound healing, spreading of epidermal cells (GO:0035313)2.29945369
157regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.27862008
158positive regulation of gamma-delta T cell activation (GO:0046645)2.25698109
159NADPH regeneration (GO:0006740)2.25344032
160negative regulation of interleukin-12 production (GO:0032695)2.21938982
161regulation of chromatin binding (GO:0035561)2.21669525
162mitotic nuclear envelope disassembly (GO:0007077)2.21312589
163protein carboxylation (GO:0018214)2.19889207
164peptidyl-glutamic acid carboxylation (GO:0017187)2.19889207
165DNA unwinding involved in DNA replication (GO:0006268)2.18959844
1663-UTR-mediated mRNA stabilization (GO:0070935)2.18734406
167negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.17699343
168pteridine-containing compound biosynthetic process (GO:0042559)2.17643358
169skin morphogenesis (GO:0043589)2.17290116
170nuclear envelope disassembly (GO:0051081)2.16901950
171membrane disassembly (GO:0030397)2.16901950
172antigen processing and presentation of endogenous antigen (GO:0019883)2.16871420
173Arp2/3 complex-mediated actin nucleation (GO:0034314)2.16246483
174dosage compensation (GO:0007549)2.15769105
175positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.14109959
176positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.13919249
177NLS-bearing protein import into nucleus (GO:0006607)2.13216898
178folic acid-containing compound metabolic process (GO:0006760)2.13205805
179regulation of interferon-beta biosynthetic process (GO:0045357)2.12912126
180positive regulation of triglyceride biosynthetic process (GO:0010867)2.12861146
181embryonic process involved in female pregnancy (GO:0060136)2.11439767
182positive regulation of lipid storage (GO:0010884)2.11379448
183pore complex assembly (GO:0046931)2.11263844
184response to endoplasmic reticulum stress (GO:0034976)2.10487384
185regulation of SMAD protein import into nucleus (GO:0060390)2.09411754
186positive regulation of chemokine biosynthetic process (GO:0045080)2.09306932
187positive regulation of interferon-alpha production (GO:0032727)2.06292649
188epithelial cell differentiation involved in prostate gland development (GO:0060742)2.06051674
189negative regulation of lipid transport (GO:0032369)2.06028232
190antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.05632864
191glycine metabolic process (GO:0006544)2.05503156
192regulation of gamma-delta T cell differentiation (GO:0045586)2.04494871
193regulation of gamma-delta T cell activation (GO:0046643)2.03936357
194apoptotic process involved in morphogenesis (GO:0060561)2.02825956
195myeloid cell homeostasis (GO:0002262)2.02680374
196regulation of hippo signaling (GO:0035330)2.02461807
197negative regulation of fatty acid biosynthetic process (GO:0045717)2.01525066
198regulation of interferon-alpha production (GO:0032647)2.01203467
199one-carbon metabolic process (GO:0006730)2.00881703

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.60766000
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.75073008
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.25913538
4POU3F2_20337985_ChIP-ChIP_501MEL_Human2.95093742
5FOXM1_23109430_ChIP-Seq_U2OS_Human2.87366705
6CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.78614258
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.75920549
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.66682595
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.64668506
10ZNF274_21170338_ChIP-Seq_K562_Hela2.53045480
11MYC_22102868_ChIP-Seq_BL_Human2.45769038
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.32986633
13GBX2_23144817_ChIP-Seq_PC3_Human2.17914317
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.17610106
15P300_19829295_ChIP-Seq_ESCs_Human2.17240983
16TAF15_26573619_Chip-Seq_HEK293_Human2.16866567
17FUS_26573619_Chip-Seq_HEK293_Human2.16314593
18AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.14342249
19* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.11068650
20VDR_22108803_ChIP-Seq_LS180_Human2.10190925
21PPARA_22158963_ChIP-Seq_LIVER_Mouse2.09064208
22IGF1R_20145208_ChIP-Seq_DFB_Human2.04314829
23RXR_22158963_ChIP-Seq_LIVER_Mouse2.03963541
24FLI1_27457419_Chip-Seq_LIVER_Mouse2.03097187
25EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.99071321
26NOTCH1_21737748_ChIP-Seq_TLL_Human1.98622037
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.96247852
28IRF8_22096565_ChIP-ChIP_GC-B_Human1.95819641
29EWS_26573619_Chip-Seq_HEK293_Human1.93494595
30SMAD_19615063_ChIP-ChIP_OVARY_Human1.88045626
31NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.84757616
32MYB_21317192_ChIP-Seq_ERMYB_Mouse1.82390139
33STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.78204700
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.78010433
35CLOCK_20551151_ChIP-Seq_293T_Human1.77735695
36BRD4_27068464_Chip-Seq_AML-cells_Mouse1.75475090
37* GABP_17652178_ChIP-ChIP_JURKAT_Human1.69996540
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.69505045
39VDR_21846776_ChIP-Seq_THP-1_Human1.69008865
40* EST1_17652178_ChIP-ChIP_JURKAT_Human1.68929843
41BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.67458014
42EZH2_27294783_Chip-Seq_NPCs_Mouse1.66395041
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.65583793
44ER_23166858_ChIP-Seq_MCF-7_Human1.64771110
45LXR_22158963_ChIP-Seq_LIVER_Mouse1.64611496
46IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.63357820
47CBP_20019798_ChIP-Seq_JUKART_Human1.63357820
48SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.62714466
49RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.62296763
50SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.62267858
51ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.61444719
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.60195877
53* ELK1_19687146_ChIP-ChIP_HELA_Human1.59958567
54MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.58355813
55SMAD4_21799915_ChIP-Seq_A2780_Human1.55617237
56RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.55083472
57PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54653613
58SMAD3_21741376_ChIP-Seq_EPCs_Human1.54587962
59NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.52812174
60* MYC_18555785_ChIP-Seq_MESCs_Mouse1.52253542
61KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.52222120
62TFEB_21752829_ChIP-Seq_HELA_Human1.52205589
63IRF8_27001747_Chip-Seq_BMDM_Mouse1.51269544
64PCGF2_27294783_Chip-Seq_ESCs_Mouse1.51115884
65ELK3_25401928_ChIP-Seq_HUVEC_Human1.50858629
66BCAT_22108803_ChIP-Seq_LS180_Human1.50802711
67IRF8_21731497_ChIP-ChIP_J774_Mouse1.50521752
68ATF3_27146783_Chip-Seq_COLON_Human1.49985710
69* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.49970307
70FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.49424818
71TCF7_22412390_ChIP-Seq_EML_Mouse1.49239633
72PIAS1_25552417_ChIP-Seq_VCAP_Human1.48866785
73* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.48396652
74NFE2_27457419_Chip-Seq_LIVER_Mouse1.48322516
75SUZ12_27294783_Chip-Seq_NPCs_Mouse1.48180642
76MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.47007614
77GATA1_22025678_ChIP-Seq_K562_Human1.45883504
78NANOG_18555785_Chip-Seq_ESCs_Mouse1.45701107
79CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.44194689
80OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43212506
81UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.42847890
82HIF1A_21447827_ChIP-Seq_MCF-7_Human1.42696560
83AHR_22903824_ChIP-Seq_MCF-7_Human1.42664277
84MAF_26560356_Chip-Seq_TH1_Human1.42208242
85* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.41942735
86CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41017786
87E2F4_17652178_ChIP-ChIP_JURKAT_Human1.38591261
88TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.38416090
89AR_25329375_ChIP-Seq_VCAP_Human1.38132016
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.38095841
91HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.37623559
92AR_21909140_ChIP-Seq_LNCAP_Human1.37593913
93EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.36700986
94CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.36422130
95KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.35909507
96CDX2_22108803_ChIP-Seq_LS180_Human1.35653190
97RARG_19884340_ChIP-ChIP_MEFs_Mouse1.35364536
98ZNF263_19887448_ChIP-Seq_K562_Human1.35198472
99UTX_26944678_Chip-Seq_JUKART_Human1.34415250
100BP1_19119308_ChIP-ChIP_Hs578T_Human1.33856140
101ARNT_22903824_ChIP-Seq_MCF-7_Human1.33027269
102MYB_26560356_Chip-Seq_TH2_Human1.31943645
103VDR_23849224_ChIP-Seq_CD4+_Human1.30726468
104STAT3_1855785_ChIP-Seq_MESCs_Mouse1.30642877
105TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30304999
106PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.29367543
107HTT_18923047_ChIP-ChIP_STHdh_Human1.29101387
108KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.28214913
109CRX_20693478_ChIP-Seq_RETINA_Mouse1.27845893
110STAT3_23295773_ChIP-Seq_U87_Human1.27533065
111HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.26169332
112SOX2_19829295_ChIP-Seq_ESCs_Human1.25325962
113NANOG_19829295_ChIP-Seq_ESCs_Human1.25325962
114* RUNX1_22412390_ChIP-Seq_EML_Mouse1.24265835
115KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.23582127
116SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.23199584
117STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.23155662
118TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22837152
119ZNF217_24962896_ChIP-Seq_MCF-7_Human1.22714519
120CMYC_18555785_Chip-Seq_ESCs_Mouse1.22439226
121SUZ12_18555785_Chip-Seq_ESCs_Mouse1.22135746
122P53_22387025_ChIP-Seq_ESCs_Mouse1.21778155
123NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21725566
124MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21430660
125P300_18555785_Chip-Seq_ESCs_Mouse1.21219137
126FOXM1_26456572_ChIP-Seq_MCF-7_Human1.20956254
127Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.20154290
128CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.19910429
129EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19776388
130E2F1_18555785_Chip-Seq_ESCs_Mouse1.19740303
131GATA6_25053715_ChIP-Seq_YYC3_Human1.19376309
132E2F1_21310950_ChIP-Seq_MCF-7_Human1.19180843
133NCOR1_26117541_ChIP-Seq_K562_Human1.19079774
134KDM2B_26808549_Chip-Seq_DND41_Human1.18820732
135CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.18433995
136GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17769493
137TCF4_22108803_ChIP-Seq_LS180_Human1.16511276
138FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.16222515
139* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.16083289
140KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15425576
141FLI1_21867929_ChIP-Seq_TH2_Mouse1.15335644
142ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.14973111
143OCT4_21477851_ChIP-Seq_ESCs_Mouse1.14240987
144MYB_26560356_Chip-Seq_TH1_Human1.13962861
145SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.13648349
146EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12957578
147NELFA_20434984_ChIP-Seq_ESCs_Mouse1.12840560
148SMAD4_21741376_ChIP-Seq_EPCs_Human1.12548545
149TCF4_23295773_ChIP-Seq_U87_Human1.12548370
150SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.12289620
151PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11912889
152KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11452676
153TP53_22573176_ChIP-Seq_HFKS_Human1.10606891
154RUNX2_22187159_ChIP-Seq_PCA_Human1.10590716
155VDR_24763502_ChIP-Seq_THP-1_Human1.10434842
156STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.10129005
157P300_27058665_Chip-Seq_ZR-75-30cells_Human1.09492944
158FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09472260
159SOX2_18555785_Chip-Seq_ESCs_Mouse1.09370705
160RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09324727
161SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.09302688
162E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.09017854
163MYC_19079543_ChIP-ChIP_MESCs_Mouse1.08998597
164STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.08958645
165RACK7_27058665_Chip-Seq_MCF-7_Human1.08955361
166STAT3_18555785_Chip-Seq_ESCs_Mouse1.08506830
167SPI1_23547873_ChIP-Seq_NB4_Human1.08395938
168POU5F1_16153702_ChIP-ChIP_HESCs_Human1.08177945
169PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.07822903
170PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07568324
171TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07128325
172FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.07065849
173SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.06746893
174MYC_18940864_ChIP-ChIP_HL60_Human1.06395252
175POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05063190
176TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05063190
177CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04550287
178AUTS2_25519132_ChIP-Seq_293T-REX_Human1.04406392
179IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.04365743
180SCL_19346495_ChIP-Seq_HPC-7_Human1.04220725
181FOXO3_23340844_ChIP-Seq_DLD1_Human1.04185419
182E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.03362879
183SOX2_27498859_Chip-Seq_STOMACH_Mouse1.01729240
184DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01446185
185IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.01383618
186CHD1_26751641_Chip-Seq_LNCaP_Human1.01320159
187FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.01195763
188KDM5A_27292631_Chip-Seq_BREAST_Human1.00658396
189* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.99071351
190* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.98776235
191TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98093236
192* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.97071287
193MYCN_18555785_ChIP-Seq_MESCs_Mouse0.95591953
194* MYC_19030024_ChIP-ChIP_MESCs_Mouse0.95506493
195SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.95424457
196SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.95424457
197* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.94734880
198FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.93717562

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting4.17156132
2MP0008877_abnormal_DNA_methylation3.93519778
3MP0006292_abnormal_olfactory_placode3.81034321
4MP0008057_abnormal_DNA_replication3.31618979
5MP0002638_abnormal_pupillary_reflex3.29666549
6MP0003705_abnormal_hypodermis_morpholog3.11361157
7MP0010352_gastrointestinal_tract_polyps3.08652423
8MP0002938_white_spotting2.72361629
9MP0003300_gastrointestinal_ulcer2.52258889
10MP0002837_dystrophic_cardiac_calcinosis2.50181478
11MP0010678_abnormal_skin_adnexa2.47674461
12MP0002877_abnormal_melanocyte_morpholog2.47269094
13MP0003303_peritoneal_inflammation2.38669974
14MP0008789_abnormal_olfactory_epithelium2.34040744
15MP0005367_renal/urinary_system_phenotyp2.10354282
16MP0000516_abnormal_urinary_system2.10354282
17MP0002102_abnormal_ear_morphology2.08431699
18MP0009840_abnormal_foam_cell2.05774457
19MP0005083_abnormal_biliary_tract2.01011514
20MP0003436_decreased_susceptibility_to1.97817123
21MP0005410_abnormal_fertilization1.94739129
22MP0003121_genomic_imprinting1.93899216
23MP0010234_abnormal_vibrissa_follicle1.93548845
24MP0005076_abnormal_cell_differentiation1.91442294
25MP0005394_taste/olfaction_phenotype1.91320113
26MP0005499_abnormal_olfactory_system1.91320113
27MP0003566_abnormal_cell_adhesion1.90276243
28MP0010307_abnormal_tumor_latency1.88806213
29MP0005058_abnormal_lysosome_morphology1.82099094
30MP0002139_abnormal_hepatobiliary_system1.81050179
31MP0005360_urolithiasis1.77702694
32MP0002693_abnormal_pancreas_physiology1.76773363
33MP0001944_abnormal_pancreas_morphology1.72092110
34MP0003806_abnormal_nucleotide_metabolis1.70469544
35MP0005379_endocrine/exocrine_gland_phen1.61169596
36MP0009278_abnormal_bone_marrow1.61050165
37MP0000613_abnormal_salivary_gland1.60495871
38MP0004947_skin_inflammation1.60008898
39MP0008058_abnormal_DNA_repair1.59978080
40MP0003252_abnormal_bile_duct1.57299293
41MP0002090_abnormal_vision1.57252214
42MP0003693_abnormal_embryo_hatching1.54873623
43MP0005023_abnormal_wound_healing1.52483448
44MP0009046_muscle_twitch1.49582037
45MP0000569_abnormal_digit_pigmentation1.48607487
46MP0005365_abnormal_bile_salt1.46961987
47MP0005248_abnormal_Harderian_gland1.46758397
48MP0000383_abnormal_hair_follicle1.46223693
49MP0006082_CNS_inflammation1.38927937
50MP0006054_spinal_hemorrhage1.37865208
51MP0009333_abnormal_splenocyte_physiolog1.37628280
52MP0003453_abnormal_keratinocyte_physiol1.37162247
53MP0001984_abnormal_olfaction1.30893522
54MP0006072_abnormal_retinal_apoptosis1.30633350
55MP0000858_altered_metastatic_potential1.28846921
56MP0005253_abnormal_eye_physiology1.24758864
57MP0000609_abnormal_liver_physiology1.23250661
58MP0002160_abnormal_reproductive_system1.23033886
59MP0003122_maternal_imprinting1.22579820
60MP0005084_abnormal_gallbladder_morpholo1.21503955
61MP0003448_altered_tumor_morphology1.21119423
62MP0002163_abnormal_gland_morphology1.20778065
63MP0003786_premature_aging1.20507981
64MP0005397_hematopoietic_system_phenotyp1.19498783
65MP0001545_abnormal_hematopoietic_system1.19498783
66MP0000685_abnormal_immune_system1.18754949
67MP0002138_abnormal_hepatobiliary_system1.18270982
68MP0008007_abnormal_cellular_replicative1.17728533
69MP0001919_abnormal_reproductive_system1.16337621
70MP0004957_abnormal_blastocyst_morpholog1.15665642
71MP0005075_abnormal_melanosome_morpholog1.15550232
72MP0003191_abnormal_cellular_cholesterol1.15071284
73MP0002405_respiratory_system_inflammati1.14191230
74MP0002419_abnormal_innate_immunity1.13791237
75MP0005464_abnormal_platelet_physiology1.12862591
76MP0005000_abnormal_immune_tolerance1.12768199
77MP0000372_irregular_coat_pigmentation1.12639844
78MP0005085_abnormal_gallbladder_physiolo1.12017413
79MP0005257_abnormal_intraocular_pressure1.11209926
80MP0001730_embryonic_growth_arrest1.10934073
81MP0001835_abnormal_antigen_presentation1.10871242
82MP0002751_abnormal_autonomic_nervous1.10084892
83MP0001533_abnormal_skeleton_physiology1.09573270
84MP0009785_altered_susceptibility_to1.09140369
85MP0000647_abnormal_sebaceous_gland1.08072762
86MP0003091_abnormal_cell_migration1.06576314
87MP0003656_abnormal_erythrocyte_physiolo1.06149333
88MP0004264_abnormal_extraembryonic_tissu1.06111724
89MP0001915_intracranial_hemorrhage1.05163740
90MP0000427_abnormal_hair_cycle1.04811374
91MP0001800_abnormal_humoral_immune1.03370036
92MP0001849_ear_inflammation1.03318385
93MP0000598_abnormal_liver_morphology1.02760449
94MP0002086_abnormal_extraembryonic_tissu1.02482538
95MP0005025_abnormal_response_to1.02097188
96MP0004197_abnormal_fetal_growth/weight/1.01852299
97MP0010155_abnormal_intestine_physiology1.01730685
98MP0005389_reproductive_system_phenotype1.01700832
99MP0002452_abnormal_antigen_presenting1.01668701
100MP0000350_abnormal_cell_proliferation1.01488066
101MP0001845_abnormal_inflammatory_respons1.01005615
102MP0003195_calcinosis1.00732600
103MP0005646_abnormal_pituitary_gland0.99262448
104MP0004808_abnormal_hematopoietic_stem0.98120896
105MP0000490_abnormal_crypts_of0.97605395
106MP0003111_abnormal_nucleus_morphology0.97081677
107MP0000733_abnormal_muscle_development0.96677043
108MP0009780_abnormal_chondrocyte_physiolo0.95087704
109MP0005387_immune_system_phenotype0.94009464
110MP0001790_abnormal_immune_system0.94009464
111MP0004185_abnormal_adipocyte_glucose0.93318855
112MP0003077_abnormal_cell_cycle0.92808465
113MP0003941_abnormal_skin_development0.91806674
114MP0002088_abnormal_embryonic_growth/wei0.91479523
115MP0003984_embryonic_growth_retardation0.91222789
116MP0003186_abnormal_redox_activity0.89926016
117MP0002398_abnormal_bone_marrow0.89706393
118MP0002723_abnormal_immune_serum0.89234964
119MP0003172_abnormal_lysosome_physiology0.88576113
120MP0010094_abnormal_chromosome_stability0.88479807
121MP0002019_abnormal_tumor_incidence0.87794348
122MP0002009_preneoplasia0.87613607
123MP0000689_abnormal_spleen_morphology0.87541959
124MP0001929_abnormal_gametogenesis0.87467359
125MP0003718_maternal_effect0.87350402
126MP0001672_abnormal_embryogenesis/_devel0.87119663
127MP0005380_embryogenesis_phenotype0.87119663
128MP0008469_abnormal_protein_level0.87020749
129MP0005551_abnormal_eye_electrophysiolog0.86858562
130MP0002909_abnormal_adrenal_gland0.86502699
131MP0001853_heart_inflammation0.85820996
132MP0008875_abnormal_xenobiotic_pharmacok0.85681239
133MP0002722_abnormal_immune_system0.85078552
134MP0002254_reproductive_system_inflammat0.84825649
135MP0005319_abnormal_enzyme/_coenzyme0.84766759
136MP0001243_abnormal_dermal_layer0.84476348
137MP0004133_heterotaxia0.84419517
138MP0005645_abnormal_hypothalamus_physiol0.83304963
139MP0001819_abnormal_immune_cell0.82318236
140MP0002420_abnormal_adaptive_immunity0.82118809
141MP0001324_abnormal_eye_pigmentation0.81619084
142MP0005167_abnormal_blood-brain_barrier0.81270587
143MP0002876_abnormal_thyroid_physiology0.81118139
144MP0008438_abnormal_cutaneous_collagen0.80481563
145MP0010329_abnormal_lipoprotein_level0.80133641
146MP0003011_delayed_dark_adaptation0.79837671
147MP0001216_abnormal_epidermal_layer0.78450493
148MP0002928_abnormal_bile_duct0.78029163
149MP0009763_increased_sensitivity_to0.77504094
150MP0001697_abnormal_embryo_size0.76659719
151MP0009643_abnormal_urine_homeostasis0.76264751
152MP0009053_abnormal_anal_canal0.76202575
153MP0008995_early_reproductive_senescence0.75866874
154MP0003795_abnormal_bone_structure0.75849354
155MP0000716_abnormal_immune_system0.75468953
156MP0002429_abnormal_blood_cell0.75300160
157MP0002080_prenatal_lethality0.75026071
158MP0005220_abnormal_exocrine_pancreas0.74093647
159MP0003890_abnormal_embryonic-extraembry0.72288625
160MP0003283_abnormal_digestive_organ0.71298401
161MP0005187_abnormal_penis_morphology0.69499836
162MP0005647_abnormal_sex_gland0.69073263
163MP0002078_abnormal_glucose_homeostasis0.68544223
164MP0008872_abnormal_physiological_respon0.67068570
165MP0005174_abnormal_tail_pigmentation0.67008701
166MP0001756_abnormal_urination0.66961714
167MP0002736_abnormal_nociception_after0.66927209
168MP0000631_abnormal_neuroendocrine_gland0.66816487
169MP0002166_altered_tumor_susceptibility0.66016416
170MP0004924_abnormal_behavior0.62058597
171MP0005386_behavior/neurological_phenoty0.62058597
172MP0010386_abnormal_urinary_bladder0.59825740
173MP0005391_vision/eye_phenotype0.59479063
174MP0001968_abnormal_touch/_nociception0.59340422
175MP0001501_abnormal_sleep_pattern0.58300590
176MP0005332_abnormal_amino_acid0.58174553
177MP0000015_abnormal_ear_pigmentation0.57644274
178MP0002006_tumorigenesis0.57265700
179MP0000653_abnormal_sex_gland0.56982616
180MP0001764_abnormal_homeostasis0.56301092
181MP0003698_abnormal_male_reproductive0.56222724
182MP0004270_analgesia0.55807710
183MP0009703_decreased_birth_body0.54385068
184MP0006036_abnormal_mitochondrial_physio0.52906216
185MP0003633_abnormal_nervous_system0.51989745
186MP0001486_abnormal_startle_reflex0.50827302

Predicted human phenotypes

RankGene SetZ-score
1Hypoplasia of the fovea (HP:0007750)5.41498268
2Aplasia/Hypoplasia of the fovea (HP:0008060)5.41498268
3Abnormality of the fovea (HP:0000493)4.36144103
4Hyperinsulinemic hypoglycemia (HP:0000825)4.26455931
5Hypoglycemic seizures (HP:0002173)4.23337580
6Aplasia/Hypoplasia of the macula (HP:0008059)3.35792996
7Aqueductal stenosis (HP:0002410)3.34857956
8Intestinal atresia (HP:0011100)3.32783229
9Abnormality of endocrine pancreas physiology (HP:0012093)3.27760206
10Abnormality of the pancreatic islet cells (HP:0006476)3.27760206
11Symptomatic seizures (HP:0011145)3.21893643
12Hypothermia (HP:0002045)3.11493621
13Hyperglycemia (HP:0003074)3.06788019
14Aplasia/Hypoplasia affecting the retina (HP:0008061)3.05336641
15Ketoacidosis (HP:0001993)3.03536446
16Myocardial infarction (HP:0001658)3.03236409
17Neoplasm of the adrenal cortex (HP:0100641)2.99690585
18Pancreatic islet-cell hyperplasia (HP:0004510)2.98889752
19Xanthomatosis (HP:0000991)2.82255890
20Eczematoid dermatitis (HP:0000976)2.80423716
21Breast carcinoma (HP:0003002)2.71987223
22Congenital malformation of the right heart (HP:0011723)2.69038260
23Double outlet right ventricle (HP:0001719)2.69038260
24Thyroiditis (HP:0100646)2.67828340
25Deep venous thrombosis (HP:0002625)2.59465228
26Esophageal varix (HP:0002040)2.58517779
27Optic nerve hypoplasia (HP:0000609)2.57553809
28Hamartoma of the eye (HP:0010568)2.56141271
29Abnormality of monocarboxylic acid metabolism (HP:0010996)2.54382640
30Vacuolated lymphocytes (HP:0001922)2.48071000
31Pancreatic cysts (HP:0001737)2.46031272
32Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.45264709
33Osteolytic defects of the hand bones (HP:0009699)2.45006331
34Osteolytic defects of the phalanges of the hand (HP:0009771)2.45006331
35Recurrent gram-negative bacterial infections (HP:0005420)2.44357942
36Methylmalonic acidemia (HP:0002912)2.43693621
37Conjunctival hamartoma (HP:0100780)2.41241845
38Hip dysplasia (HP:0001385)2.36521366
39Increased cerebral lipofuscin (HP:0011813)2.34942170
40Biliary tract neoplasm (HP:0100574)2.33531924
41Ulnar bowing (HP:0003031)2.33431296
42Increased density of long bones (HP:0006392)2.32032829
43Axonal loss (HP:0003447)2.31333283
44Neoplasm of the adrenal gland (HP:0100631)2.31212728
45Cervical subluxation (HP:0003308)2.31204895
46Subacute progressive viral hepatitis (HP:0006572)2.29324374
47Autoimmune thrombocytopenia (HP:0001973)2.28775546
48Abnormality of the common coagulation pathway (HP:0010990)2.28477980
49Tetraparesis (HP:0002273)2.24021115
50Thyroid carcinoma (HP:0002890)2.23285463
51Cerebral aneurysm (HP:0004944)2.23044299
52Enlarged penis (HP:0000040)2.22554315
53Intrahepatic cholestasis (HP:0001406)2.22163193
54Urinary glycosaminoglycan excretion (HP:0003541)2.20884965
55Mucopolysacchariduria (HP:0008155)2.20884965
56Hematochezia (HP:0002573)2.18654006
57Insulin-resistant diabetes mellitus (HP:0000831)2.18047600
58Increased mean platelet volume (HP:0011877)2.15025912
59Metaphyseal cupping (HP:0003021)2.14987107
60Progressive inability to walk (HP:0002505)2.13295847
61Stomatitis (HP:0010280)2.12248267
62Peritonitis (HP:0002586)2.12115329
63Reticulocytosis (HP:0001923)2.11495403
64Interstitial pulmonary disease (HP:0006530)2.08874933
65Abnormal platelet volume (HP:0011876)2.08446135
66Curly hair (HP:0002212)2.08279863
67Meningioma (HP:0002858)2.07709138
68Hand muscle atrophy (HP:0009130)2.06920887
69Prominent metopic ridge (HP:0005487)2.04522929
70Abnormality of aromatic amino acid family metabolism (HP:0004338)2.03775248
71Flat acetabular roof (HP:0003180)2.03652538
72Tongue fasciculations (HP:0001308)2.03346968
73Rhabdomyosarcoma (HP:0002859)2.03198196
74Abnormality of complement system (HP:0005339)2.03126202
75Hepatocellular carcinoma (HP:0001402)2.01343704
76Back pain (HP:0003418)2.01107921
77Large for gestational age (HP:0001520)2.00933713
78Abnormal pancreas size (HP:0012094)2.00738284
79Abnormality of vitamin B metabolism (HP:0004340)2.00639084
80True hermaphroditism (HP:0010459)1.99947235
81Pustule (HP:0200039)1.99816164
82Distal upper limb amyotrophy (HP:0007149)1.99300017
83Upper limb amyotrophy (HP:0009129)1.99300017
84Abnormality of macrophages (HP:0004311)1.99219082
85EEG with generalized epileptiform discharges (HP:0011198)1.97836983
86Abnormality of the metopic suture (HP:0005556)1.97549878
87Ketosis (HP:0001946)1.97251349
88Hypsarrhythmia (HP:0002521)1.95567825
89Abnormality of chromosome stability (HP:0003220)1.95406162
90Increased serum ferritin (HP:0003281)1.95386193
91Ependymoma (HP:0002888)1.94457864
92Premature rupture of membranes (HP:0001788)1.94363746
93Dysostosis multiplex (HP:0000943)1.94066750
94Global brain atrophy (HP:0002283)1.92655333
95Spastic diplegia (HP:0001264)1.92570447
96Abnormality of mucopolysaccharide metabolism (HP:0011020)1.92200281
97Abnormality of polysaccharide metabolism (HP:0011012)1.92200281
98Abnormality of glycosaminoglycan metabolism (HP:0004371)1.92200281
99Recurrent viral infections (HP:0004429)1.90898607
100Abnormality of iron homeostasis (HP:0011031)1.90784830
101Progressive macrocephaly (HP:0004481)1.90527448
102Pancreatic fibrosis (HP:0100732)1.90085476
103Epileptiform EEG discharges (HP:0011182)1.87452739
104Increased neuronal autofluorescent lipopigment (HP:0002074)1.87113412
105Recurrent abscess formation (HP:0002722)1.84397399
106Persistence of primary teeth (HP:0006335)1.84333194
107Abnormality of transition element cation homeostasis (HP:0011030)1.83954964
108Abnormal platelet function (HP:0011869)1.82857648
109Impaired platelet aggregation (HP:0003540)1.82857648
110Muscular hypotonia of the trunk (HP:0008936)1.81883152
111Furrowed tongue (HP:0000221)1.81702545
112Pendular nystagmus (HP:0012043)1.81661264
113Thoracolumbar scoliosis (HP:0002944)1.81450206
114Poikilocytosis (HP:0004447)1.80961894
115Albinism (HP:0001022)1.80946620
116Hypomagnesemia (HP:0002917)1.80351967
117Abnormal foot bone ossification (HP:0010675)1.80248336
118Fair hair (HP:0002286)1.79532632
119Abnormal cartilage morphology (HP:0002763)1.79445300
120Multiple enchondromatosis (HP:0005701)1.78825131
121Abnormality of the parathyroid morphology (HP:0011766)1.78066415
122Abnormal biliary tract morphology (HP:0012440)1.77762343
123Hydroxyprolinuria (HP:0003080)1.76710151
124Abnormality of proline metabolism (HP:0010907)1.76710151
125Abnormality of glutamine family amino acid metabolism (HP:0010902)1.76621363
126Neoplasm of the tracheobronchial system (HP:0100552)1.76234215
127Gaze-evoked nystagmus (HP:0000640)1.75881688
128Papillary thyroid carcinoma (HP:0002895)1.75727067
129Uterine neoplasm (HP:0010784)1.75709270
130Recurrent bacterial skin infections (HP:0005406)1.75621635
131Abnormality of the intrinsic pathway (HP:0010989)1.75011551
132Hypercholesterolemia (HP:0003124)1.74810910
133Protrusio acetabuli (HP:0003179)1.74732549
134Joint hemorrhage (HP:0005261)1.74441306
135Methylmalonic aciduria (HP:0012120)1.74318320
136Cupped ribs (HP:0000887)1.74248638
137Complement deficiency (HP:0004431)1.73105698
138T lymphocytopenia (HP:0005403)1.71890220
139Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.71017062
140Hypobetalipoproteinemia (HP:0003563)1.70122112
141Optic nerve coloboma (HP:0000588)1.69301927
142Recurrent fungal infections (HP:0002841)1.69012277
143Abnormality of the preputium (HP:0100587)1.68614662
144Aplasia/Hypoplasia of the uvula (HP:0010293)1.68144542
145Mutism (HP:0002300)1.67940087
146Meckel diverticulum (HP:0002245)1.67668962
147Abnormality of the labia minora (HP:0012880)1.67298245
148Micronodular cirrhosis (HP:0001413)1.67224611
149Severe short stature (HP:0003510)1.66669432
150Polycythemia (HP:0001901)1.66532523
151Menorrhagia (HP:0000132)1.64709858
152Aneurysm (HP:0002617)1.64553682
153Oligodactyly (hands) (HP:0001180)1.64001052
154Abnormality of the astrocytes (HP:0100707)1.63465215
155Astrocytoma (HP:0009592)1.63465215
156Abnormality of the renal cortex (HP:0011035)1.63214272
157Abnormality of the ileum (HP:0001549)1.63172898
158Abnormality of the distal phalanges of the toes (HP:0010182)1.63146775
159Peripheral demyelination (HP:0011096)1.63013270
160Radial bowing (HP:0002986)1.62742120
161Congenital stationary night blindness (HP:0007642)1.62528931
162Disinhibition (HP:0000734)1.62500867
163Adenoma sebaceum (HP:0009720)1.62476249
164Angiofibromas (HP:0010615)1.62476249
165Generalized myoclonic seizures (HP:0002123)1.61478996
166Abnormality of T cell number (HP:0011839)1.61477594
167Muscle fibrillation (HP:0010546)1.61474023
168Genu recurvatum (HP:0002816)1.61419422
169Mitral valve prolapse (HP:0001634)1.61396325
170Vertebral clefting (HP:0008428)1.60985637
171Abnormality of sulfur amino acid metabolism (HP:0004339)1.59682553
172Transitional cell carcinoma of the bladder (HP:0006740)1.59586451
173Difficulty running (HP:0009046)1.59275447
174Abnormality of aspartate family amino acid metabolism (HP:0010899)1.59240698
175Ulnar deviation of the wrist (HP:0003049)1.59221224
176Hypoglycemic coma (HP:0001325)1.59165235
177Ovarian neoplasm (HP:0100615)1.59103703
178Pseudobulbar signs (HP:0002200)1.58658613
179Disproportionate short-trunk short stature (HP:0003521)1.58505314
180Abnormality of the duodenum (HP:0002246)1.58466246
181Aplasia/hypoplasia of the uterus (HP:0008684)1.58116279
182Cutaneous melanoma (HP:0012056)1.57489477
183Nephronophthisis (HP:0000090)1.56361441
184Gingival bleeding (HP:0000225)1.56352020
185Generalized hyperpigmentation (HP:0007440)1.56088081
186Systemic lupus erythematosus (HP:0002725)1.55773569
187Malignant gastrointestinal tract tumors (HP:0006749)1.55541025
188Gastrointestinal carcinoma (HP:0002672)1.55541025
189Increased CSF protein (HP:0002922)1.55409509
190Epidermoid cyst (HP:0200040)1.55314557
191Thoracic kyphosis (HP:0002942)1.55178011
192Upper motor neuron abnormality (HP:0002127)1.54863650

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM283.66745719
2EIF2AK33.55779020
3MST43.12186999
4TRIB32.96344332
5ERN12.83523588
6CDK122.63497347
7TNIK2.62604072
8WNK32.51924775
9PKN22.46300794
10MKNK22.43588463
11ACVR1B2.40456114
12MAP3K102.38228740
13EPHA22.33831402
14EEF2K2.32012945
15ERBB32.26804300
16MAP4K22.18588499
17FGFR22.15848150
18MAPK132.14157777
19SIK32.12536532
20RPS6KA42.03145383
21STK101.99237037
22PLK21.98876208
23TAOK31.89695449
24INSRR1.82914504
25MAP3K31.80924190
26PTK61.72128868
27PLK31.70804211
28BMPR1B1.69396982
29PTK2B1.59200450
30STK38L1.55407846
31CDK61.53618597
32STK241.53579144
33GRK11.52179409
34MKNK11.51941681
35FER1.50737050
36MAP2K31.49260832
37LRRK21.45867316
38LATS11.42286643
39RIPK11.41695385
40NUAK11.41498219
41EIF2AK11.40265816
42TBK11.39836334
43STK31.39568775
44FGFR41.39084754
45MAP3K141.35109782
46TTN1.32951495
47NEK91.32148765
48MAP4K11.31949307
49FLT31.31869315
50STK391.30129426
51TYK21.28460583
52MAP3K81.27767327
53NEK21.27669317
54CSNK1G11.27577775
55NME21.25735209
56SCYL21.25128008
57OXSR11.24561697
58PAK31.24321291
59RPS6KB21.23049172
60JAK31.22711039
61SRPK11.22654141
62BRD41.18628667
63PIM21.18627978
64BCR1.18580028
65MAP3K41.17479432
66TSSK61.16242265
67ALK1.16106884
68BMX1.15087984
69EPHB11.14929846
70CDK41.14809693
71ZAP701.11561192
72IRAK31.11196214
73PDGFRA1.09733812
74CSNK1G31.09720822
75PAK41.05552574
76IRAK21.05390653
77YES11.04669764
78CSNK1G21.04219442
79PASK1.04174793
80ADRBK21.03844806
81MTOR1.03833027
82MST1R1.03058714
83PIM11.02695453
84MAPKAPK31.02141697
85SIK10.99644412
86FRK0.99572187
87CDC70.99114848
88CSK0.97968964
89MET0.96045207
90TGFBR20.94916360
91CSNK1A1L0.88427827
92MAP3K110.88038542
93TESK10.87372512
94CAMK1D0.86858846
95BLK0.86755609
96PAK20.85673532
97BUB10.84353545
98DYRK1B0.84314184
99PNCK0.84084430
100CHUK0.84056909
101PLK40.83660524
102PINK10.83614408
103STK40.83530020
104PTK20.82909229
105ERBB40.80864518
106ZAK0.79970004
107AKT30.77205234
108CASK0.77144916
109KDR0.76636659
110BRSK20.75793413
111FGFR30.75474754
112ITK0.73076746
113TTK0.71445173
114PHKG20.71368489
115PHKG10.71368489
116JAK20.69800943
117JAK10.69210687
118PDK20.69181422
119IKBKB0.67512416
120GRK60.67084930
121TAOK10.66285146
122TAF10.65198685
123PRKCE0.63423954
124MAP2K20.63399132
125CDK70.63086741
126BMPR20.61605310
127EGFR0.61482693
128TESK20.61327441
129PDGFRB0.61097839
130MELK0.60353004
131WEE10.60269101
132HIPK20.60173109
133MARK30.58100995
134CDK30.57326784
135GSK3A0.57032964
136PRKCG0.55929213
137TRPM70.55809453
138MAP2K70.55671273
139EIF2AK20.55654633
140MAP3K50.54729374
141IRAK40.54011244
142TGFBR10.53201753
143DYRK30.52355101
144SGK20.52216703
145BTK0.50716321
146PLK10.50338177
147MAPKAPK20.50261043
148CDK90.50218670
149HCK0.48978336
150MAP3K20.48056313
151MAPK110.47892167
152AURKB0.46190709
153CSF1R0.45673008
154LCK0.41677543
155CHEK10.40338825
156PRKCI0.40224698
157ATM0.39778460
158DDR20.38590221
159NLK0.38038045
160CSNK1D0.35883228
161IRAK10.35168918
162KSR10.32065617
163GRK70.27622370
164DAPK20.27609083
165CAMK1G0.27346470
166VRK10.27174122
167TXK0.26675008
168MAP3K90.26147097
169BRSK10.25923678
170CSNK1A10.25828328
171PRKAA20.25548916
172FGR0.25418215
173ABL10.24955469
174MARK10.24695365
175FGFR10.24574613
176SGK30.23084113
177MAP3K120.22383021
178MAP2K10.21782771

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.78322996
2Vitamin B6 metabolism_Homo sapiens_hsa007503.23370531
3Proteasome_Homo sapiens_hsa030502.47910135
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.41039990
5Non-homologous end-joining_Homo sapiens_hsa034502.39894105
6Collecting duct acid secretion_Homo sapiens_hsa049662.17770302
7One carbon pool by folate_Homo sapiens_hsa006702.02417944
8Butanoate metabolism_Homo sapiens_hsa006502.01111805
9Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.00409736
10Staphylococcus aureus infection_Homo sapiens_hsa051501.92837935
11Selenocompound metabolism_Homo sapiens_hsa004501.91745316
12Nitrogen metabolism_Homo sapiens_hsa009101.85647290
13Basal transcription factors_Homo sapiens_hsa030221.74779469
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.72926097
15Legionellosis_Homo sapiens_hsa051341.70855318
16Fatty acid elongation_Homo sapiens_hsa000621.69653097
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.68023833
18Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.64283530
19Leishmaniasis_Homo sapiens_hsa051401.62098020
20Fanconi anemia pathway_Homo sapiens_hsa034601.61469047
21RNA degradation_Homo sapiens_hsa030181.61347989
22Sulfur metabolism_Homo sapiens_hsa009201.59205731
23Propanoate metabolism_Homo sapiens_hsa006401.55413554
24Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.53431972
25Caffeine metabolism_Homo sapiens_hsa002321.52490179
26Complement and coagulation cascades_Homo sapiens_hsa046101.52179796
27Chronic myeloid leukemia_Homo sapiens_hsa052201.51882737
28NF-kappa B signaling pathway_Homo sapiens_hsa040641.51174553
29Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.51160939
30Type II diabetes mellitus_Homo sapiens_hsa049301.47789085
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.46921912
32Phototransduction_Homo sapiens_hsa047441.45254841
33Antigen processing and presentation_Homo sapiens_hsa046121.44596006
34Regulation of autophagy_Homo sapiens_hsa041401.41743750
35Type I diabetes mellitus_Homo sapiens_hsa049401.40903099
36Sphingolipid metabolism_Homo sapiens_hsa006001.38722330
37Apoptosis_Homo sapiens_hsa042101.36372755
38Small cell lung cancer_Homo sapiens_hsa052221.33394833
39Folate biosynthesis_Homo sapiens_hsa007901.32811509
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.31727851
41Sulfur relay system_Homo sapiens_hsa041221.30826014
42Maturity onset diabetes of the young_Homo sapiens_hsa049501.28524916
43Circadian rhythm_Homo sapiens_hsa047101.26858743
44Lysosome_Homo sapiens_hsa041421.25388152
45Osteoclast differentiation_Homo sapiens_hsa043801.23802574
46Rheumatoid arthritis_Homo sapiens_hsa053231.18509781
47Glycosaminoglycan degradation_Homo sapiens_hsa005311.18462482
48Primary bile acid biosynthesis_Homo sapiens_hsa001201.18342421
49TNF signaling pathway_Homo sapiens_hsa046681.17049498
50Dorso-ventral axis formation_Homo sapiens_hsa043201.16269951
51p53 signaling pathway_Homo sapiens_hsa041151.15989254
52Toxoplasmosis_Homo sapiens_hsa051451.12432364
53Pentose and glucuronate interconversions_Homo sapiens_hsa000401.10341314
54Bladder cancer_Homo sapiens_hsa052191.10191357
55Arginine biosynthesis_Homo sapiens_hsa002201.10017013
56Malaria_Homo sapiens_hsa051441.09090522
57Viral carcinogenesis_Homo sapiens_hsa052031.08481721
58Insulin secretion_Homo sapiens_hsa049111.07931298
59Hematopoietic cell lineage_Homo sapiens_hsa046401.06867922
60Toll-like receptor signaling pathway_Homo sapiens_hsa046201.06409109
61Acute myeloid leukemia_Homo sapiens_hsa052211.04740489
62Drug metabolism - other enzymes_Homo sapiens_hsa009831.03497820
63Oocyte meiosis_Homo sapiens_hsa041141.03274978
64Ether lipid metabolism_Homo sapiens_hsa005651.02568625
65Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.02327093
66MicroRNAs in cancer_Homo sapiens_hsa052061.01328365
67Homologous recombination_Homo sapiens_hsa034400.99672188
68Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.98368063
69Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.98111824
70Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.97054661
71Measles_Homo sapiens_hsa051620.96529365
72NOD-like receptor signaling pathway_Homo sapiens_hsa046210.96164474
73Pancreatic cancer_Homo sapiens_hsa052120.95545029
74Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.95498066
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.94376321
76Proteoglycans in cancer_Homo sapiens_hsa052050.94372024
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.94084388
78Insulin resistance_Homo sapiens_hsa049310.93997055
79Hepatitis B_Homo sapiens_hsa051610.93469177
80Tuberculosis_Homo sapiens_hsa051520.91643523
81Amoebiasis_Homo sapiens_hsa051460.90943689
82Lysine degradation_Homo sapiens_hsa003100.89771270
83Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.88971977
84Pertussis_Homo sapiens_hsa051330.88523986
85Adherens junction_Homo sapiens_hsa045200.87411955
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.87261893
87mTOR signaling pathway_Homo sapiens_hsa041500.86953816
88RNA transport_Homo sapiens_hsa030130.86715117
89B cell receptor signaling pathway_Homo sapiens_hsa046620.85990574
90Shigellosis_Homo sapiens_hsa051310.85226351
91Prostate cancer_Homo sapiens_hsa052150.84997310
92Herpes simplex infection_Homo sapiens_hsa051680.84457480
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.84434235
94Pentose phosphate pathway_Homo sapiens_hsa000300.81806117
95Viral myocarditis_Homo sapiens_hsa054160.78692124
96Peroxisome_Homo sapiens_hsa041460.78163632
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.76729113
98Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75859060
99Influenza A_Homo sapiens_hsa051640.75717909
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73688720
101Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73633261
102Jak-STAT signaling pathway_Homo sapiens_hsa046300.73506533
103Other glycan degradation_Homo sapiens_hsa005110.73198627
104Cell cycle_Homo sapiens_hsa041100.72507416
105Hepatitis C_Homo sapiens_hsa051600.72391853
106Steroid biosynthesis_Homo sapiens_hsa001000.71075717
107Tryptophan metabolism_Homo sapiens_hsa003800.70651169
108Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69986634
109Histidine metabolism_Homo sapiens_hsa003400.69747682
110AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.69394717
111Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.68479759
112Mineral absorption_Homo sapiens_hsa049780.68255447
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68139630
114Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.68007689
115HTLV-I infection_Homo sapiens_hsa051660.67684284
116RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.67570691
117Asthma_Homo sapiens_hsa053100.66945346
118RNA polymerase_Homo sapiens_hsa030200.66564003
119Thyroid cancer_Homo sapiens_hsa052160.65800610
120Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.65328497
121Fat digestion and absorption_Homo sapiens_hsa049750.64615653
122Epstein-Barr virus infection_Homo sapiens_hsa051690.62938081
123Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62779749
124DNA replication_Homo sapiens_hsa030300.61933889
125PPAR signaling pathway_Homo sapiens_hsa033200.61181658
126Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.60215776
127Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.60023712
128Focal adhesion_Homo sapiens_hsa045100.59275595
129Vibrio cholerae infection_Homo sapiens_hsa051100.59179268
130Central carbon metabolism in cancer_Homo sapiens_hsa052300.57954048
131Biosynthesis of amino acids_Homo sapiens_hsa012300.57223052
132Neurotrophin signaling pathway_Homo sapiens_hsa047220.56365752
133FoxO signaling pathway_Homo sapiens_hsa040680.56249883
134Fatty acid degradation_Homo sapiens_hsa000710.54530738
135Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53731611
136Ovarian steroidogenesis_Homo sapiens_hsa049130.52818151
137Starch and sucrose metabolism_Homo sapiens_hsa005000.52669191
138Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.52319553
139Phagosome_Homo sapiens_hsa041450.51942992
140mRNA surveillance pathway_Homo sapiens_hsa030150.51277471
141T cell receptor signaling pathway_Homo sapiens_hsa046600.51276161
142Glutathione metabolism_Homo sapiens_hsa004800.51065864
143Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.50617499
144HIF-1 signaling pathway_Homo sapiens_hsa040660.50490133
145Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.50294301
146Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.49673972
147Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49199364
148ECM-receptor interaction_Homo sapiens_hsa045120.48814922
149Linoleic acid metabolism_Homo sapiens_hsa005910.48640969
150Salmonella infection_Homo sapiens_hsa051320.46439370
151Amphetamine addiction_Homo sapiens_hsa050310.43848376
152beta-Alanine metabolism_Homo sapiens_hsa004100.41654827
153TGF-beta signaling pathway_Homo sapiens_hsa043500.41244466
154Metabolic pathways_Homo sapiens_hsa011000.38406429
155Cysteine and methionine metabolism_Homo sapiens_hsa002700.38098894
156Inositol phosphate metabolism_Homo sapiens_hsa005620.37967086
157Fatty acid metabolism_Homo sapiens_hsa012120.36298051
158Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.32396007
159Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.31126477
160N-Glycan biosynthesis_Homo sapiens_hsa005100.30877940
161Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.29660412
162alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28706733
163Oxidative phosphorylation_Homo sapiens_hsa001900.26449865
164Serotonergic synapse_Homo sapiens_hsa047260.25784691
165Synaptic vesicle cycle_Homo sapiens_hsa047210.24485276
166Steroid hormone biosynthesis_Homo sapiens_hsa001400.23644425
167Purine metabolism_Homo sapiens_hsa002300.20874977

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