EAF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine metabolic process (GO:0046087)8.22638780
2cytidine catabolic process (GO:0006216)8.22638780
3cytidine deamination (GO:0009972)8.22638780
4somatic hypermutation of immunoglobulin genes (GO:0016446)7.20415729
5somatic diversification of immune receptors via somatic mutation (GO:0002566)7.20415729
6pyrimidine ribonucleoside catabolic process (GO:0046133)7.02702858
7complement activation, classical pathway (GO:0006958)5.61456768
8signal peptide processing (GO:0006465)5.50361475
9regulation of B cell receptor signaling pathway (GO:0050855)5.17841724
10immunoglobulin mediated immune response (GO:0016064)5.11164591
11B cell mediated immunity (GO:0019724)4.52049167
12regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.31704587
13neutrophil activation involved in immune response (GO:0002283)4.19899954
14negative regulation of glucose import (GO:0046325)4.17792535
15complement activation (GO:0006956)4.15589427
16superoxide anion generation (GO:0042554)4.08843006
17B cell receptor signaling pathway (GO:0050853)4.06100755
18cellular response to zinc ion (GO:0071294)3.91998826
19positive regulation of B cell differentiation (GO:0045579)3.75226485
20somatic diversification of immunoglobulins (GO:0016445)3.72873741
21regulation of germinal center formation (GO:0002634)3.72510890
22regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.64329764
23mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.64075100
24negative regulation of B cell apoptotic process (GO:0002903)3.59290170
25deoxyribose phosphate catabolic process (GO:0046386)3.58563159
26purine deoxyribonucleotide catabolic process (GO:0009155)3.57786498
27B cell proliferation (GO:0042100)3.53678946
28regulation of B cell apoptotic process (GO:0002902)3.51860857
29regulation of B cell proliferation (GO:0030888)3.47823197
30mature B cell differentiation involved in immune response (GO:0002313)3.47813936
31regulation of dendritic cell antigen processing and presentation (GO:0002604)3.47241837
32positive regulation of mast cell activation involved in immune response (GO:0033008)3.45741605
33positive regulation of mast cell degranulation (GO:0043306)3.45741605
34ATP synthesis coupled proton transport (GO:0015986)3.45343885
35energy coupled proton transport, down electrochemical gradient (GO:0015985)3.45343885
36cell wall macromolecule catabolic process (GO:0016998)3.40606309
37regulation of chromatin silencing (GO:0031935)3.39069064
38deoxyribonucleotide catabolic process (GO:0009264)3.37566716
39regulation of hypersensitivity (GO:0002883)3.36387973
40deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.35141451
41detection of other organism (GO:0098543)3.32685262
42positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.32395247
43positive regulation of mast cell activation (GO:0033005)3.31651971
44purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.30835170
45DNA demethylation (GO:0080111)3.26143348
46regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.24512795
47antigen processing and presentation of endogenous antigen (GO:0019883)3.23463334
48detection of bacterium (GO:0016045)3.22344109
49negative regulation of glucose transport (GO:0010829)3.21193367
50negative regulation of mast cell activation (GO:0033004)3.20503782
51negative regulation of B cell proliferation (GO:0030889)3.18316129
52pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.17920778
53ribosomal small subunit assembly (GO:0000028)3.17305018
54histamine secretion (GO:0001821)3.17050136
55cell wall macromolecule metabolic process (GO:0044036)3.12484996
56germinal center formation (GO:0002467)3.11850898
57mast cell activation (GO:0045576)3.05665294
58interferon-gamma-mediated signaling pathway (GO:0060333)3.05161271
59mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.99781384
60DNA deamination (GO:0045006)2.99629365
61humoral immune response (GO:0006959)2.99416186
62positive regulation of antigen processing and presentation (GO:0002579)2.95828225
63positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.94511505
64positive regulation of immunoglobulin production (GO:0002639)2.92799088
65DNA integration (GO:0015074)2.92681563
66protein activation cascade (GO:0072376)2.92029630
67negative regulation of growth of symbiont in host (GO:0044130)2.92028446
68negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.92028446
69modulation of growth of symbiont involved in interaction with host (GO:0044144)2.92028446
70regulation of growth of symbiont in host (GO:0044126)2.92028446
71deoxyribose phosphate metabolic process (GO:0019692)2.90389597
72chaperone mediated protein folding requiring cofactor (GO:0051085)2.89074442
73DNA dealkylation (GO:0035510)2.88529360
74adenosine metabolic process (GO:0046085)2.87950139
75somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.87800727
76isotype switching (GO:0045190)2.87800727
77somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.87800727
78regulation of mast cell activation (GO:0033003)2.86532874
79response to peptidoglycan (GO:0032494)2.83193003
80somatic diversification of immune receptors (GO:0002200)2.82809175
81DNA strand renaturation (GO:0000733)2.81970377
82oxidative phosphorylation (GO:0006119)2.81717230
83Arp2/3 complex-mediated actin nucleation (GO:0034314)2.80875298
84regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.80733151
85regulation of activation of Janus kinase activity (GO:0010533)2.80655300
86respiratory electron transport chain (GO:0022904)2.80627272
87purine deoxyribonucleotide metabolic process (GO:0009151)2.79965221
88positive regulation of protein homooligomerization (GO:0032464)2.79939257
89maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.79378832
90regulation of T-helper 1 cell differentiation (GO:0045625)2.79162370
91somatic recombination of immunoglobulin gene segments (GO:0016447)2.78345637
92purine nucleotide salvage (GO:0032261)2.78237464
93centriole assembly (GO:0098534)2.77911712
94DNA synthesis involved in DNA repair (GO:0000731)2.76962581
95electron transport chain (GO:0022900)2.75673105
96B cell homeostasis (GO:0001782)2.75569486
97rRNA modification (GO:0000154)2.74956650
98response to interferon-beta (GO:0035456)2.74794200
99negative regulation of keratinocyte proliferation (GO:0010839)2.74367926
1002-deoxyribonucleotide metabolic process (GO:0009394)2.74235248
101cellular response to interferon-beta (GO:0035458)2.74091091
102B cell activation involved in immune response (GO:0002312)2.73951487
103thrombin receptor signaling pathway (GO:0070493)2.73831310
104positive regulation of alpha-beta T cell proliferation (GO:0046641)2.73753032
105protein complex biogenesis (GO:0070271)2.73353668
106positive regulation of gamma-delta T cell activation (GO:0046645)2.73033969
107regulation of mast cell degranulation (GO:0043304)2.71633361
108regulation of antigen processing and presentation (GO:0002577)2.71443104
109mature B cell differentiation (GO:0002335)2.71209334
110respiratory burst (GO:0045730)2.70541940
111pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.67182975
112mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.65884432
113mitochondrial respiratory chain complex I assembly (GO:0032981)2.65884432
114NADH dehydrogenase complex assembly (GO:0010257)2.65884432
115positive thymic T cell selection (GO:0045059)2.65384687
116regulation of B cell differentiation (GO:0045577)2.64692007
117viral transcription (GO:0019083)2.64570289
118negative regulation of gene silencing (GO:0060969)2.62769315
119pyrimidine nucleoside catabolic process (GO:0046135)2.61659445
120tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.60989321
121RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.60989321
122proteasome assembly (GO:0043248)2.60615692
123antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.60412035
124regulation of mast cell activation involved in immune response (GO:0033006)2.59117571
125B cell activation (GO:0042113)2.59038991
126regulation of B cell activation (GO:0050864)2.58773961
127microglial cell activation (GO:0001774)2.58424449
128daunorubicin metabolic process (GO:0044597)2.58385667
129polyketide metabolic process (GO:0030638)2.58385667
130doxorubicin metabolic process (GO:0044598)2.58385667
131SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.56870136
132neutrophil activation (GO:0042119)2.56522516
133replicative senescence (GO:0090399)2.56344478
134purine-containing compound salvage (GO:0043101)2.56030335
135negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.55697339
136pyrimidine nucleotide catabolic process (GO:0006244)2.54482296
137positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.54195895
138mismatch repair (GO:0006298)2.54090568
139antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.54075395
140sphingosine metabolic process (GO:0006670)2.54027170
141regulation of alpha-beta T cell proliferation (GO:0046640)2.51802677
142L-fucose catabolic process (GO:0042355)2.51277720
143fucose catabolic process (GO:0019317)2.51277720
144L-fucose metabolic process (GO:0042354)2.51277720
145translational termination (GO:0006415)2.50940061
146telomere maintenance via semi-conservative replication (GO:0032201)2.50667353
147mast cell degranulation (GO:0043303)2.50438021
148mast cell activation involved in immune response (GO:0002279)2.50438021
149cotranslational protein targeting to membrane (GO:0006613)2.50405694
150replication fork processing (GO:0031297)2.50264921
151negative regulation of DNA-dependent DNA replication (GO:2000104)2.49931348
152positive regulation of B cell proliferation (GO:0030890)2.49539471
153hydrogen peroxide biosynthetic process (GO:0050665)2.49531694
154tongue development (GO:0043586)2.49450025
155protein targeting to ER (GO:0045047)2.48266930
156myeloid cell activation involved in immune response (GO:0002275)2.48013501
157histamine transport (GO:0051608)2.47839892
158regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.46986860
159cellular response to interferon-gamma (GO:0071346)2.46623000
160mitochondrial respiratory chain complex assembly (GO:0033108)2.46540152
161amine catabolic process (GO:0009310)2.46440713
162cellular biogenic amine catabolic process (GO:0042402)2.46440713
163deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.45993889
164cellular response to exogenous dsRNA (GO:0071360)2.44176345
165negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.44067970
166deoxyribonucleotide metabolic process (GO:0009262)2.42359638
167base-excision repair, AP site formation (GO:0006285)2.42314390
168negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.42179971
169centriole replication (GO:0007099)2.40620346
170regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.40532886
171dendritic cell chemotaxis (GO:0002407)2.39735800
172positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.39615848
173nucleotide transmembrane transport (GO:1901679)2.39173714
174protein localization to endoplasmic reticulum (GO:0070972)2.38742211
175cellular response to ATP (GO:0071318)2.38688058
176telomere maintenance via recombination (GO:0000722)2.38616295
177purinergic nucleotide receptor signaling pathway (GO:0035590)2.38347211
178detection of external biotic stimulus (GO:0098581)2.37044523
179detection of molecule of bacterial origin (GO:0032490)2.36082866
180tRNA methylation (GO:0030488)2.35841218
181positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.34518154
182meiotic chromosome segregation (GO:0045132)2.34084722
183exocrine pancreas development (GO:0031017)2.31694594
184sphingoid metabolic process (GO:0046519)2.31544090
185DNA catabolic process, exonucleolytic (GO:0000738)2.31465043
186negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.31015083
187dendritic cell migration (GO:0036336)2.30237665
188negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.30186328
189diol metabolic process (GO:0034311)2.29884057

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.65136644
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.11129042
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.68033321
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.66437098
5PCGF2_27294783_Chip-Seq_ESCs_Mouse3.28331952
6FLI1_27457419_Chip-Seq_LIVER_Mouse3.22436707
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.07975830
8E2F7_22180533_ChIP-Seq_HELA_Human3.05674434
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.91609618
10PCGF2_27294783_Chip-Seq_NPCs_Mouse2.82927565
11NFE2_27457419_Chip-Seq_LIVER_Mouse2.70483747
12SUZ12_27294783_Chip-Seq_NPCs_Mouse2.66746493
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.65364104
14SCL_19346495_ChIP-Seq_HPC-7_Human2.64638500
15VDR_23849224_ChIP-Seq_CD4+_Human2.50545765
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.39699149
17EZH2_27294783_Chip-Seq_NPCs_Mouse2.30202529
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.26673884
19KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.16411275
20MYC_18555785_ChIP-Seq_MESCs_Mouse2.12861624
21BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.10850892
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.09993610
23GBX2_23144817_ChIP-Seq_PC3_Human2.09888158
24ETS1_20019798_ChIP-Seq_JURKAT_Human2.05468317
25ZFP57_27257070_Chip-Seq_ESCs_Mouse2.02380109
26HOXB4_20404135_ChIP-ChIP_EML_Mouse2.01671312
27NOTCH1_21737748_ChIP-Seq_TLL_Human1.97405340
28CREB1_15753290_ChIP-ChIP_HEK293T_Human1.95453319
29MYB_26560356_Chip-Seq_TH2_Human1.92677267
30STAT3_18555785_Chip-Seq_ESCs_Mouse1.91610591
31EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.88245788
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.86504036
33P53_22387025_ChIP-Seq_ESCs_Mouse1.83768055
34SUZ12_18555785_Chip-Seq_ESCs_Mouse1.83060956
35EGR1_23403033_ChIP-Seq_LIVER_Mouse1.80504055
36NMYC_18555785_Chip-Seq_ESCs_Mouse1.78847457
37RUNX1_27457419_Chip-Seq_LIVER_Mouse1.76348156
38EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.74343091
39BP1_19119308_ChIP-ChIP_Hs578T_Human1.73669580
40STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.72776787
41NANOG_18555785_Chip-Seq_ESCs_Mouse1.70298758
42EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.67418260
43BMI1_23680149_ChIP-Seq_NPCS_Mouse1.65606498
44MYC_18358816_ChIP-ChIP_MESCs_Mouse1.65473028
45ZFX_18555785_Chip-Seq_ESCs_Mouse1.65335406
46CIITA_25753668_ChIP-Seq_RAJI_Human1.63741116
47TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.63209337
48SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.60530076
49OCT4_21477851_ChIP-Seq_ESCs_Mouse1.60324944
50P300_18555785_Chip-Seq_ESCs_Mouse1.59291026
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.59251495
52E2F1_18555785_Chip-Seq_ESCs_Mouse1.57473076
53CRX_20693478_ChIP-Seq_RETINA_Mouse1.56912194
54* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.56560837
55IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.55874083
56SMAD1_18555785_Chip-Seq_ESCs_Mouse1.55102255
57HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.53790602
58IRF8_27001747_Chip-Seq_BMDM_Mouse1.53416679
59SOX2_18555785_Chip-Seq_ESCs_Mouse1.53163522
60PU1_27457419_Chip-Seq_LIVER_Mouse1.52661340
61CMYC_18555785_Chip-Seq_ESCs_Mouse1.52341137
62OCT4_18555785_Chip-Seq_ESCs_Mouse1.51506067
63ESRRB_18555785_Chip-Seq_ESCs_Mouse1.50790210
64KLF4_18555785_Chip-Seq_ESCs_Mouse1.50619770
65RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.47687286
66MYB_21317192_ChIP-Seq_ERMYB_Mouse1.46319465
67NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.46010193
68CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.45329007
69STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.42926146
70CTCF_18555785_Chip-Seq_ESCs_Mouse1.42531661
71MYB_26560356_Chip-Seq_TH1_Human1.35842259
72FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.35478039
73TP63_19390658_ChIP-ChIP_HaCaT_Human1.34247884
74* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.32723840
75SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.32541234
76CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.32447714
77KAP1_22055183_ChIP-Seq_ESCs_Mouse1.30799486
78* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.30361468
79FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.30150713
80SRF_21415370_ChIP-Seq_HL-1_Mouse1.30110572
81GABP_17652178_ChIP-ChIP_JURKAT_Human1.28965240
82CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.26473054
83GATA3_27048872_Chip-Seq_THYMUS_Human1.26292333
84LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.23633188
85IRF1_19129219_ChIP-ChIP_H3396_Human1.21390079
86ELK1_19687146_ChIP-ChIP_HELA_Human1.21378580
87VDR_24763502_ChIP-Seq_THP-1_Human1.21159467
88PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.21116568
89DCP1A_22483619_ChIP-Seq_HELA_Human1.20996902
90MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.20895690
91VDR_22108803_ChIP-Seq_LS180_Human1.19385578
92FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18650710
93SMAD_19615063_ChIP-ChIP_OVARY_Human1.18116840
94* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17079379
95ERG_20887958_ChIP-Seq_HPC-7_Mouse1.16983934
96CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.14986375
97* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.14740974
98* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.13080586
99PIAS1_25552417_ChIP-Seq_VCAP_Human1.13050253
100TAL1_26923725_Chip-Seq_HPCs_Mouse1.12071216
101STAT4_19710469_ChIP-ChIP_TH1__Mouse1.11208113
102MYC_18940864_ChIP-ChIP_HL60_Human1.10980191
103PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10910538
104* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.10371509
105HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.09249205
106FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06974563
107FOXP3_21729870_ChIP-Seq_TREG_Human1.06786236
108MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06773525
109CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.06613170
110MYC_19079543_ChIP-ChIP_MESCs_Mouse1.05485899
111IGF1R_20145208_ChIP-Seq_DFB_Human1.05338363
112* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.04529389
113FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.03365058
114ERG_20517297_ChIP-Seq_VCAP_Human1.03355533
115MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.01482365
116HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.98131245
117CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97903095
118EWS_26573619_Chip-Seq_HEK293_Human0.97582006
119PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96551568
120NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.96454288
121SPI1_23127762_ChIP-Seq_K562_Human0.96293598
122GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96154434
123ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.95917611
124HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.95321871
125CBX2_27304074_Chip-Seq_ESCs_Mouse0.95321106
126TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.95152796
127BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95060111
128RUNX1_22412390_ChIP-Seq_EML_Mouse0.94707620
129GABP_19822575_ChIP-Seq_HepG2_Human0.94311665
130SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.94030686
131FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.93616784
132SPI1_23547873_ChIP-Seq_NB4_Human0.93524768
133LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.92840875
134GATA2_22383799_ChIP-Seq_G1ME_Mouse0.92788786
135ER_23166858_ChIP-Seq_MCF-7_Human0.92671626
136GATA3_26560356_Chip-Seq_TH2_Human0.90913311
137E2F1_21310950_ChIP-Seq_MCF-7_Human0.90441063
138ZNF274_21170338_ChIP-Seq_K562_Hela0.90434199
139EST1_17652178_ChIP-ChIP_JURKAT_Human0.90251058
140VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.90215657
141GATA1_22025678_ChIP-Seq_K562_Human0.90119442
142PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.90032027
143FOXA1_25329375_ChIP-Seq_VCAP_Human0.89746360
144FOXA1_27270436_Chip-Seq_PROSTATE_Human0.89746360
145P300_19829295_ChIP-Seq_ESCs_Human0.89624098
146KDM2B_26808549_Chip-Seq_REH_Human0.89117793
147GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88881712
148RUNX_20019798_ChIP-Seq_JUKART_Human0.88606320
149Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.87289860
150TTF2_22483619_ChIP-Seq_HELA_Human0.86733025
151AR_20517297_ChIP-Seq_VCAP_Human0.86346036
152EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.85761227
153SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.84745128
154FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.84712696
155STAT1_20625510_ChIP-Seq_HELA_Human0.83282368

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.33327773
2MP0003806_abnormal_nucleotide_metabolis4.12251469
3MP0001800_abnormal_humoral_immune3.35240237
4MP0005387_immune_system_phenotype3.27659750
5MP0001790_abnormal_immune_system3.27659750
6MP0005451_abnormal_body_composition2.95919899
7MP0005464_abnormal_platelet_physiology2.95728878
8MP0005671_abnormal_response_to2.83950381
9MP0003195_calcinosis2.67384299
10MP0003136_yellow_coat_color2.58275614
11MP0002452_abnormal_antigen_presenting2.58089381
12MP0001188_hyperpigmentation2.55674172
13MP0003724_increased_susceptibility_to2.55225398
14MP0008058_abnormal_DNA_repair2.38872239
15MP0006292_abnormal_olfactory_placode2.37977722
16MP0002148_abnormal_hypersensitivity_rea2.34856276
17MP0010386_abnormal_urinary_bladder2.29976097
18MP0009379_abnormal_foot_pigmentation2.29495468
19MP0002723_abnormal_immune_serum2.27447656
20MP0005000_abnormal_immune_tolerance2.26489318
21MP0000015_abnormal_ear_pigmentation2.22802994
22MP0008057_abnormal_DNA_replication2.20551762
23MP0002396_abnormal_hematopoietic_system2.16875689
24MP0008260_abnormal_autophagy2.10073181
25MP0003303_peritoneal_inflammation2.08867116
26MP0002420_abnormal_adaptive_immunity2.06443671
27MP0001819_abnormal_immune_cell2.03170732
28MP0002876_abnormal_thyroid_physiology2.00582297
29MP0006036_abnormal_mitochondrial_physio1.99598200
30MP0002163_abnormal_gland_morphology1.99184692
31MP0004381_abnormal_hair_follicle1.95939520
32MP0001545_abnormal_hematopoietic_system1.94154322
33MP0005397_hematopoietic_system_phenotyp1.94154322
34MP0009785_altered_susceptibility_to1.92059016
35MP0002132_abnormal_respiratory_system1.89912315
36MP0000685_abnormal_immune_system1.84385742
37MP0000566_synostosis1.83172924
38MP0009697_abnormal_copulation1.80809136
39MP0003763_abnormal_thymus_physiology1.80648111
40MP0005025_abnormal_response_to1.76361564
41MP0005645_abnormal_hypothalamus_physiol1.73316923
42MP0000716_abnormal_immune_system1.70762614
43MP0002398_abnormal_bone_marrow1.65985110
44MP0005379_endocrine/exocrine_gland_phen1.65314961
45MP0002277_abnormal_respiratory_mucosa1.62573603
46MP0000465_gastrointestinal_hemorrhage1.62328839
47MP0002419_abnormal_innate_immunity1.60948892
48MP0002933_joint_inflammation1.60764924
49MP0002102_abnormal_ear_morphology1.60268541
50MP0005310_abnormal_salivary_gland1.59395658
51MP0003693_abnormal_embryo_hatching1.58838083
52MP0005084_abnormal_gallbladder_morpholo1.56318594
53MP0010094_abnormal_chromosome_stability1.53712935
54MP0004147_increased_porphyrin_level1.51961140
55MP0005075_abnormal_melanosome_morpholog1.48107538
56MP0008007_abnormal_cellular_replicative1.47793514
57MP0003172_abnormal_lysosome_physiology1.47504440
58MP0002693_abnormal_pancreas_physiology1.46547121
59MP0003718_maternal_effect1.46524299
60MP0003186_abnormal_redox_activity1.44720102
61MP0001986_abnormal_taste_sensitivity1.42954371
62MP0000689_abnormal_spleen_morphology1.42818881
63MP0002009_preneoplasia1.42192971
64MP0004808_abnormal_hematopoietic_stem1.40620347
65MP0002138_abnormal_hepatobiliary_system1.38911085
66MP0000681_abnormal_thyroid_gland1.32510629
67MP0002429_abnormal_blood_cell1.30717589
68MP0003866_abnormal_defecation1.29867190
69MP0001845_abnormal_inflammatory_respons1.29229202
70MP0008469_abnormal_protein_level1.28454137
71MP0003075_altered_response_to1.25730100
72MP0000490_abnormal_crypts_of1.22820103
73MP0008872_abnormal_physiological_respon1.22474445
74MP0008875_abnormal_xenobiotic_pharmacok1.18034472
75MP0009764_decreased_sensitivity_to1.15609363
76MP0002722_abnormal_immune_system1.13906471
77MP0002095_abnormal_skin_pigmentation1.13443713
78MP0009278_abnormal_bone_marrow1.11900603
79MP0000013_abnormal_adipose_tissue1.11130750
80MP0008995_early_reproductive_senescence1.10155270
81MP0001919_abnormal_reproductive_system1.09637851
82MP0000678_abnormal_parathyroid_gland1.07998987
83* MP0002019_abnormal_tumor_incidence1.07725421
84MP0006035_abnormal_mitochondrial_morpho1.06477364
85MP0003656_abnormal_erythrocyte_physiolo1.05505452
86MP0001853_heart_inflammation1.05265678
87MP0004782_abnormal_surfactant_physiolog1.04853772
88MP0004019_abnormal_vitamin_homeostasis1.04549984
89MP0001879_abnormal_lymphatic_vessel1.03257361
90MP0000372_irregular_coat_pigmentation1.03191092
91MP0001346_abnormal_lacrimal_gland1.01751013
92MP0003436_decreased_susceptibility_to1.00255930
93MP0005220_abnormal_exocrine_pancreas0.97246436
94MP0010155_abnormal_intestine_physiology0.96278090
95MP0003252_abnormal_bile_duct0.96261163
96MP0001944_abnormal_pancreas_morphology0.95502993
97MP0009763_increased_sensitivity_to0.94024240
98MP0000538_abnormal_urinary_bladder0.93731106
99MP0001764_abnormal_homeostasis0.93588988
100MP0002405_respiratory_system_inflammati0.92094244
101MP0000427_abnormal_hair_cycle0.91209890
102MP0005389_reproductive_system_phenotype0.90879374
103MP0009765_abnormal_xenobiotic_induced0.90791177
104MP0008004_abnormal_stomach_pH0.90783586
105MP0005647_abnormal_sex_gland0.89651301
106MP0005410_abnormal_fertilization0.89381878
107MP0000613_abnormal_salivary_gland0.87735923
108MP0001905_abnormal_dopamine_level0.87162525
109MP0002006_tumorigenesis0.84236277
110MP0009333_abnormal_splenocyte_physiolog0.83882286
111MP0001873_stomach_inflammation0.83480741
112* MP0001191_abnormal_skin_condition0.83422491
113MP0005409_darkened_coat_color0.82942838
114MP0000703_abnormal_thymus_morphology0.82848806
115MP0003786_premature_aging0.82203470
116MP0005166_decreased_susceptibility_to0.82016567
117MP0001533_abnormal_skeleton_physiology0.81852304
118MP0001661_extended_life_span0.81706692
119MP0005165_increased_susceptibility_to0.81013327
120MP0008873_increased_physiological_sensi0.79277783
121MP0005319_abnormal_enzyme/_coenzyme0.77647317
122MP0003183_abnormal_peptide_metabolism0.77542776
123MP0002136_abnormal_kidney_physiology0.76718038
124MP0002166_altered_tumor_susceptibility0.76172607
125MP0006072_abnormal_retinal_apoptosis0.76027540
126MP0003111_abnormal_nucleus_morphology0.74431150
127MP0003638_abnormal_response/metabolism_0.71514969
128MP0002928_abnormal_bile_duct0.71262487
129MP0005171_absent_coat_pigmentation0.70846252
130MP0003077_abnormal_cell_cycle0.70533989
131MP0003868_abnormal_feces_composition0.70130454
132MP0003787_abnormal_imprinting0.70016296
133MP0004264_abnormal_extraembryonic_tissu0.69964801
134MP0006054_spinal_hemorrhage0.69054684
135MP0000343_altered_response_to0.68760562
136MP0005174_abnormal_tail_pigmentation0.67499395
137MP0000569_abnormal_digit_pigmentation0.67174579
138MP0008877_abnormal_DNA_methylation0.66719886
139MP0009643_abnormal_urine_homeostasis0.66281471
140MP0004957_abnormal_blastocyst_morpholog0.66143690
141MP0001881_abnormal_mammary_gland0.66012366
142MP0001186_pigmentation_phenotype0.65661466
143MP0005266_abnormal_metabolism0.65622539
144MP0002098_abnormal_vibrissa_morphology0.65090883
145MP0000003_abnormal_adipose_tissue0.64885418
146MP0005646_abnormal_pituitary_gland0.64513743
147MP0004947_skin_inflammation0.63923850
148MP0006082_CNS_inflammation0.63166144

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)6.64702713
2Recurrent sinusitis (HP:0011108)5.05456269
3Gastrointestinal stroma tumor (HP:0100723)4.84370476
4Recurrent pneumonia (HP:0006532)4.60508459
5Recurrent lower respiratory tract infections (HP:0002783)4.23685977
6Chromosomal breakage induced by crosslinking agents (HP:0003221)4.02109195
7Acute necrotizing encephalopathy (HP:0006965)3.89238488
8Abnormality of B cell number (HP:0010975)3.85421957
9B lymphocytopenia (HP:0010976)3.85421957
10Mitochondrial inheritance (HP:0001427)3.73687439
11Abnormal mitochondria in muscle tissue (HP:0008316)3.62022515
12Recurrent bronchitis (HP:0002837)3.58109244
13Meningitis (HP:0001287)3.57954838
14Chromsome breakage (HP:0040012)3.56400548
15Elevated erythrocyte sedimentation rate (HP:0003565)3.55801955
16Hepatocellular necrosis (HP:0001404)3.46876050
17Colitis (HP:0002583)3.46585935
18Progressive macrocephaly (HP:0004481)3.40988533
19Abnormal delayed hypersensitivity skin test (HP:0002963)3.39396000
20Dry hair (HP:0011359)3.37073522
21Increased CSF lactate (HP:0002490)3.31874016
22Acute encephalopathy (HP:0006846)3.31490989
23Cellulitis (HP:0100658)3.29515989
24Chronic sinusitis (HP:0011109)3.15434472
25Hepatic necrosis (HP:0002605)3.14473747
26Onycholysis (HP:0001806)3.13515826
27Petechiae (HP:0000967)3.12406161
28Inflammation of the large intestine (HP:0002037)3.11041203
29Recurrent viral infections (HP:0004429)3.03206692
30Thrombocytosis (HP:0001894)3.01973445
31IgA deficiency (HP:0002720)2.99268531
32Vasculitis (HP:0002633)2.99004897
33IgG deficiency (HP:0004315)2.92670985
34Renal Fanconi syndrome (HP:0001994)2.90757546
353-Methylglutaconic aciduria (HP:0003535)2.89168846
36Increased hepatocellular lipid droplets (HP:0006565)2.86962284
37IgM deficiency (HP:0002850)2.85515879
38Stomatitis (HP:0010280)2.82331616
39Prolonged bleeding time (HP:0003010)2.78771433
40Lymphopenia (HP:0001888)2.77523628
41Gastrointestinal inflammation (HP:0004386)2.77022602
42Lipid accumulation in hepatocytes (HP:0006561)2.76463335
43Recurrent abscess formation (HP:0002722)2.74473308
44Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.73329222
45Decreased activity of mitochondrial respiratory chain (HP:0008972)2.73329222
46Abnormality of cells of the lymphoid lineage (HP:0012140)2.69613950
47Osteomyelitis (HP:0002754)2.67515312
48Autoimmune hemolytic anemia (HP:0001890)2.65769980
49Conical tooth (HP:0000698)2.65485706
50Abnormality of T cell physiology (HP:0011840)2.62455052
51Abnormality of the preputium (HP:0100587)2.61654577
52Aplastic anemia (HP:0001915)2.61508059
53Cerebral edema (HP:0002181)2.59787478
54Increased intramyocellular lipid droplets (HP:0012240)2.59271634
55Autoimmune thrombocytopenia (HP:0001973)2.58220850
56Decreased electroretinogram (ERG) amplitude (HP:0000654)2.57148524
57Aplasia/Hypoplasia of the uvula (HP:0010293)2.55467537
58Neutropenia (HP:0001875)2.55451155
59Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.55169195
60Exertional dyspnea (HP:0002875)2.54533063
61Panhypogammaglobulinemia (HP:0003139)2.53635399
62Chest pain (HP:0100749)2.51215670
63Abnormality of male internal genitalia (HP:0000022)2.47039922
64Amaurosis fugax (HP:0100576)2.46879565
65Recurrent bacterial skin infections (HP:0005406)2.45892034
66Epistaxis (HP:0000421)2.45592576
67Emphysema (HP:0002097)2.43614861
68Leukopenia (HP:0001882)2.42928138
69Recurrent otitis media (HP:0000403)2.42504644
70Increased serum lactate (HP:0002151)2.41755494
71Eczematoid dermatitis (HP:0000976)2.40899557
72Bronchitis (HP:0012387)2.39989261
73Granulocytopenia (HP:0001913)2.38520897
74Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.38516394
75Chronic mucocutaneous candidiasis (HP:0002728)2.36479958
76Recurrent cutaneous fungal infections (HP:0011370)2.36479958
77Prostate neoplasm (HP:0100787)2.36418980
78Abnormality of incisor morphology (HP:0011063)2.34112413
79Abnormality of chromosome stability (HP:0003220)2.32109569
80Upper limb muscle weakness (HP:0003484)2.30778678
81Lactic acidosis (HP:0003128)2.30245590
82Abnormality of the vasculature of the conjunctiva (HP:0008054)2.30081844
83Clubbing of toes (HP:0100760)2.25635227
84Abnormality of the heme biosynthetic pathway (HP:0010472)2.25456870
85Increased muscle lipid content (HP:0009058)2.25263102
86Renal cortical cysts (HP:0000803)2.23964113
87Eosinophilia (HP:0001880)2.21420953
88Acute hepatic failure (HP:0006554)2.20587965
89Pulmonary fibrosis (HP:0002206)2.19604368
90Retrobulbar optic neuritis (HP:0100654)2.18773543
91Optic neuritis (HP:0100653)2.18773543
92Respiratory failure (HP:0002878)2.16212056
93Sepsis (HP:0100806)2.14836808
94Meckel diverticulum (HP:0002245)2.11821514
95Abnormal protein glycosylation (HP:0012346)2.10903746
96Abnormal glycosylation (HP:0012345)2.10903746
97Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.10903746
98Abnormal protein N-linked glycosylation (HP:0012347)2.10903746
99Verrucae (HP:0200043)2.09456286
100Papilloma (HP:0012740)2.09456286
101Recurrent fungal infections (HP:0002841)2.08935684
102Recurrent skin infections (HP:0001581)2.08641420
103Gingival bleeding (HP:0000225)2.07577961
104Encephalitis (HP:0002383)2.07183221
105Febrile seizures (HP:0002373)2.07050775
106Acute lymphatic leukemia (HP:0006721)2.06567993
107Severe combined immunodeficiency (HP:0004430)2.06163305
108Chronic diarrhea (HP:0002028)2.05014758
109Optic disc pallor (HP:0000543)2.03498848
110Skin rash (HP:0000988)2.02885532
111Hypoplasia of the fovea (HP:0007750)2.01074416
112Aplasia/Hypoplasia of the fovea (HP:0008060)2.01074416
113Squamous cell carcinoma (HP:0002860)2.00867035
114Congenital sensorineural hearing impairment (HP:0008527)2.00767776
115Abnormality of the prostate (HP:0008775)2.00492448
116Mediastinal lymphadenopathy (HP:0100721)2.00209953
117Thyroiditis (HP:0100646)2.00107064
118Abnormality of the ileum (HP:0001549)1.99890644
119Osteomalacia (HP:0002749)1.99487119
120Microvesicular hepatic steatosis (HP:0001414)1.98670350
121Exercise intolerance (HP:0003546)1.98255689
122Congenital, generalized hypertrichosis (HP:0004540)1.97540703
123Recurrent gram-negative bacterial infections (HP:0005420)1.97252853
124Conjugated hyperbilirubinemia (HP:0002908)1.96582737
125Abnormality of aspartate family amino acid metabolism (HP:0010899)1.96241596
126Restrictive lung disease (HP:0002091)1.96153516
127Lymphoma (HP:0002665)1.94687507
128Chronic obstructive pulmonary disease (HP:0006510)1.94462485
129Obstructive lung disease (HP:0006536)1.94462485
130Abnormality of T cells (HP:0002843)1.94222602
131Abnormality of the pleura (HP:0002103)1.92413343
132Arterial thrombosis (HP:0004420)1.89993628
133Vascular calcification (HP:0004934)1.89729360
134Leukodystrophy (HP:0002415)1.89261008
135Decreased central vision (HP:0007663)1.88197739
136Abnormality of the renal collecting system (HP:0004742)1.88148816
137Abolished electroretinogram (ERG) (HP:0000550)1.87105386
138Bronchiectasis (HP:0002110)1.86609476
139Abnormal number of erythroid precursors (HP:0012131)1.86100739
140Pulmonary infiltrates (HP:0002113)1.85995709
141Abnormality of renal resorption (HP:0011038)1.85700413
142Abnormality of cells of the erythroid lineage (HP:0012130)1.85533619
143Hemoptysis (HP:0002105)1.85442050
144Purpura (HP:0000979)1.85242607
145Medial flaring of the eyebrow (HP:0010747)1.85054685
146Abnormality of dicarboxylic acid metabolism (HP:0010995)1.84883184
147Dicarboxylic aciduria (HP:0003215)1.84883184
148Type I transferrin isoform profile (HP:0003642)1.83596805
149Myelodysplasia (HP:0002863)1.82939913
150Stomach cancer (HP:0012126)1.82765465
151Hypothermia (HP:0002045)1.80555695
152Gingivitis (HP:0000230)1.80372255
153Myositis (HP:0100614)1.79605837
154True hermaphroditism (HP:0010459)1.79398865
155Urticaria (HP:0001025)1.78621031
156Erythema (HP:0010783)1.75880419
157Chronic hepatic failure (HP:0100626)1.74896981
158Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.73837742
159Premature loss of primary teeth (HP:0006323)1.73386617
160Bone marrow hypocellularity (HP:0005528)1.73198390
161Dehydration (HP:0001944)1.72033350
162Alveolar cell carcinoma (HP:0006519)1.71614951
163Abnormality of DNA repair (HP:0003254)1.68633515
16411 pairs of ribs (HP:0000878)1.66973275
165Vacuolated lymphocytes (HP:0001922)1.64257501
166Xerostomia (HP:0000217)1.63861435

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.37731996
2IRAK33.36227820
3MAP3K143.07354307
4MAP4K12.90037948
5IRAK42.74894808
6CASK2.74682556
7INSRR2.60155967
8ZAK2.37660303
9BLK2.37113299
10EIF2AK22.31852477
11TESK22.30413173
12MST42.28516469
13GRK12.20807237
14FES1.97567169
15TLK11.96024690
16PIK3CG1.93138673
17MAP3K121.88640702
18BRD41.86112857
19TEC1.82807402
20BMPR21.77500557
21STK161.77055088
22SYK1.73536202
23ERN11.72789179
24SCYL21.68438489
25TXK1.67745200
26FRK1.67128562
27MKNK21.66643048
28CDK191.63043272
29FLT31.61163242
30KDR1.53871685
31PLK41.51910133
32EIF2AK31.49491951
33LYN1.43248962
34IKBKB1.41479040
35YES11.41088328
36MAP2K71.34439791
37SIK31.33037490
38IKBKE1.32457101
39TAOK31.29139621
40WNK31.26989257
41MAPK151.25466499
42PRKCH1.20866796
43TBK11.18757856
44RIPK41.18349445
45MAP3K131.18266995
46TNIK1.18178010
47IRAK11.16672207
48PRKCI1.16581975
49MAPKAPK51.16218348
50PRKCQ1.14834059
51BTK1.08636993
52JAK31.08310466
53BCR1.06583260
54GRK61.03545045
55DAPK11.02416795
56VRK11.02266327
57CDK81.02264165
58SRPK11.02191940
59CSF1R1.01514504
60KIT0.94435536
61NUAK10.93857709
62NEK90.93651432
63CHUK0.93475702
64PRKCE0.93183690
65ITK0.92512035
66AKT30.91958632
67TRPM70.91209705
68STK38L0.90939904
69NME20.90881539
70MATK0.89823036
71CDC70.88298959
72MKNK10.88271546
73CDK30.88201328
74NLK0.86582109
75ERBB30.86446106
76CLK10.86276934
77GRK70.83714089
78MAP4K20.82091521
79STK240.80335265
80MYLK0.79357078
81EIF2AK10.78252305
82ATR0.77332310
83RPS6KA50.76430974
84OXSR10.75767013
85BRSK20.75373877
86BMPR1B0.67876170
87PBK0.66845619
88PKN10.66844613
89DAPK30.66390848
90BUB10.65329344
91RPS6KB10.64898298
92IRAK20.63706006
93BCKDK0.63612514
94RPS6KB20.63310863
95PASK0.62444768
96TYK20.61703360
97ADRBK20.60313706
98DYRK30.60267866
99SGK20.59768774
100CDC42BPA0.59279237
101MAPK130.57595037
102ABL10.57120530
103PIM10.56871637
104CSNK1G30.55764847
105PRKCD0.55641669
106LCK0.55121748
107TIE10.55042535
108HIPK20.52832907
109EPHA30.52823568
110JAK10.50544845
111TAF10.49726419
112ILK0.48358462
113EPHB20.46509998
114MAP2K30.45993634
115TNK20.45935343
116CCNB10.44919537
117AURKB0.44210438
118CHEK20.43907228
119CSNK2A20.42724759
120CDK90.42615102
121ABL20.42221880
122NEK10.41564395
123MUSK0.41231186
124ZAP700.40981723
125CSNK1G20.40821648
126PIM20.39830827
127BRAF0.37836072
128CSNK2A10.37822961
129RPS6KA40.37636094
130STK40.37342419
131PLK30.36890863
132DYRK1A0.36192116
133IGF1R0.35433087
134PLK10.35309246
135GRK50.34840005
136CSNK1A10.34309139
137CSNK1A1L0.34088296
138PRKCG0.34082049
139HCK0.33982833
140NME10.32895855
141ATM0.30475881
142MARK30.29710068
143MAP2K20.29508858
144MAPK110.28645766
145EGFR0.28486110
146MAPK40.26030778

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.39031001
2Protein export_Homo sapiens_hsa030604.16565966
3Intestinal immune network for IgA production_Homo sapiens_hsa046724.02297955
4Non-homologous end-joining_Homo sapiens_hsa034502.71960385
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.67110005
6Base excision repair_Homo sapiens_hsa034102.66818272
7Fanconi anemia pathway_Homo sapiens_hsa034602.59801843
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.49399312
9Ribosome_Homo sapiens_hsa030102.34428295
10Mismatch repair_Homo sapiens_hsa034302.26658789
11Oxidative phosphorylation_Homo sapiens_hsa001902.26247676
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.21922658
13Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.07123485
14Parkinsons disease_Homo sapiens_hsa050122.06810980
15DNA replication_Homo sapiens_hsa030302.01187126
16Viral myocarditis_Homo sapiens_hsa054162.00906797
17Graft-versus-host disease_Homo sapiens_hsa053321.96576983
18Homologous recombination_Homo sapiens_hsa034401.92827175
19Autoimmune thyroid disease_Homo sapiens_hsa053201.84271602
20B cell receptor signaling pathway_Homo sapiens_hsa046621.78899396
21Systemic lupus erythematosus_Homo sapiens_hsa053221.69615502
22Allograft rejection_Homo sapiens_hsa053301.68217607
23Hematopoietic cell lineage_Homo sapiens_hsa046401.63300873
24Regulation of autophagy_Homo sapiens_hsa041401.60473545
25SNARE interactions in vesicular transport_Homo sapiens_hsa041301.55998713
26Asthma_Homo sapiens_hsa053101.53406721
27Pyrimidine metabolism_Homo sapiens_hsa002401.49977774
28Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.49020343
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.48257504
30RNA polymerase_Homo sapiens_hsa030201.44297236
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.40124976
32Other glycan degradation_Homo sapiens_hsa005111.35471929
33Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.29500491
34Nucleotide excision repair_Homo sapiens_hsa034201.27233207
35Type I diabetes mellitus_Homo sapiens_hsa049401.24692501
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.22838130
37Antigen processing and presentation_Homo sapiens_hsa046121.19979419
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.19037275
39Alzheimers disease_Homo sapiens_hsa050101.18417088
40Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.17848205
41Measles_Homo sapiens_hsa051621.14248958
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.14043229
43Huntingtons disease_Homo sapiens_hsa050161.10313613
44NOD-like receptor signaling pathway_Homo sapiens_hsa046211.10309973
45Sphingolipid metabolism_Homo sapiens_hsa006001.09523788
46Histidine metabolism_Homo sapiens_hsa003401.08233747
47Herpes simplex infection_Homo sapiens_hsa051681.06342942
48Phenylalanine metabolism_Homo sapiens_hsa003601.05093199
49One carbon pool by folate_Homo sapiens_hsa006701.01708727
50Folate biosynthesis_Homo sapiens_hsa007900.98733029
51Spliceosome_Homo sapiens_hsa030400.97634596
52Toll-like receptor signaling pathway_Homo sapiens_hsa046200.96329455
53Rheumatoid arthritis_Homo sapiens_hsa053230.92336831
54Proteasome_Homo sapiens_hsa030500.89630008
55Toxoplasmosis_Homo sapiens_hsa051450.89613844
56p53 signaling pathway_Homo sapiens_hsa041150.85884314
57N-Glycan biosynthesis_Homo sapiens_hsa005100.85581826
58Purine metabolism_Homo sapiens_hsa002300.83021926
59Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.82373706
60Basal transcription factors_Homo sapiens_hsa030220.78139659
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.77229944
62Leishmaniasis_Homo sapiens_hsa051400.77002225
63Vitamin digestion and absorption_Homo sapiens_hsa049770.74455891
64Steroid hormone biosynthesis_Homo sapiens_hsa001400.73189185
65Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.72751812
66TNF signaling pathway_Homo sapiens_hsa046680.69939821
67Platelet activation_Homo sapiens_hsa046110.69140196
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68739088
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.67296727
70Tryptophan metabolism_Homo sapiens_hsa003800.66052486
71Jak-STAT signaling pathway_Homo sapiens_hsa046300.65229351
72Retinol metabolism_Homo sapiens_hsa008300.63984437
73Glycosaminoglycan degradation_Homo sapiens_hsa005310.61798629
74beta-Alanine metabolism_Homo sapiens_hsa004100.61745995
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60900597
76Phototransduction_Homo sapiens_hsa047440.60378719
77Arachidonic acid metabolism_Homo sapiens_hsa005900.59895039
78Tuberculosis_Homo sapiens_hsa051520.57148397
79ABC transporters_Homo sapiens_hsa020100.54974430
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54027234
81Cardiac muscle contraction_Homo sapiens_hsa042600.53659184
82Osteoclast differentiation_Homo sapiens_hsa043800.53282775
83Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.53153610
84Influenza A_Homo sapiens_hsa051640.52569563
85Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.52483983
86Epstein-Barr virus infection_Homo sapiens_hsa051690.51487610
87Legionellosis_Homo sapiens_hsa051340.51072676
88Linoleic acid metabolism_Homo sapiens_hsa005910.49872012
89Tyrosine metabolism_Homo sapiens_hsa003500.49196786
90RNA transport_Homo sapiens_hsa030130.49030253
91Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.49006918
92Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48478282
93Apoptosis_Homo sapiens_hsa042100.47699442
94Olfactory transduction_Homo sapiens_hsa047400.47442543
95Glutathione metabolism_Homo sapiens_hsa004800.44919756
96Staphylococcus aureus infection_Homo sapiens_hsa051500.43129445
97Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.42634539
98Fatty acid elongation_Homo sapiens_hsa000620.40050104
99Propanoate metabolism_Homo sapiens_hsa006400.39088354
100Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.38496598
101Peroxisome_Homo sapiens_hsa041460.38446354
102Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37922026
103Phagosome_Homo sapiens_hsa041450.37296467
104T cell receptor signaling pathway_Homo sapiens_hsa046600.36862220
105Pertussis_Homo sapiens_hsa051330.36164370
106Steroid biosynthesis_Homo sapiens_hsa001000.35932670
107Arginine and proline metabolism_Homo sapiens_hsa003300.35771979
108Hepatitis C_Homo sapiens_hsa051600.34527919
109Hepatitis B_Homo sapiens_hsa051610.34313883
110Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33510557
111Nitrogen metabolism_Homo sapiens_hsa009100.33230960
112RNA degradation_Homo sapiens_hsa030180.32914465
113Chemical carcinogenesis_Homo sapiens_hsa052040.32746861
114Malaria_Homo sapiens_hsa051440.32642100
115Sulfur metabolism_Homo sapiens_hsa009200.30601475
116Metabolic pathways_Homo sapiens_hsa011000.29753717
117Drug metabolism - other enzymes_Homo sapiens_hsa009830.29453280
118Taste transduction_Homo sapiens_hsa047420.29302463
119Collecting duct acid secretion_Homo sapiens_hsa049660.28274648
120Lysosome_Homo sapiens_hsa041420.27900954
121Transcriptional misregulation in cancer_Homo sapiens_hsa052020.27148170
122Vibrio cholerae infection_Homo sapiens_hsa051100.26907432
123Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26816283
124African trypanosomiasis_Homo sapiens_hsa051430.25169769
125HTLV-I infection_Homo sapiens_hsa051660.18687849
126Caffeine metabolism_Homo sapiens_hsa002320.18625663
127Pentose phosphate pathway_Homo sapiens_hsa000300.17844474
128Ether lipid metabolism_Homo sapiens_hsa005650.17242069
129Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.15334322

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