EAPP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a phosphoprotein that interacts with several members of the E2F family of proteins. The protein localizes to the nucleus, and is present throughout the cell cycle except during mitosis. It functions to modulate E2F-regulated transcription and stimulate proliferation. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1termination of RNA polymerase III transcription (GO:0006386)5.04188878
2transcription elongation from RNA polymerase III promoter (GO:0006385)5.04188878
3proteasome assembly (GO:0043248)4.59020365
4establishment of protein localization to mitochondrial membrane (GO:0090151)4.43022293
57-methylguanosine mRNA capping (GO:0006370)4.38815737
67-methylguanosine RNA capping (GO:0009452)4.37424572
7RNA capping (GO:0036260)4.37424572
8protein neddylation (GO:0045116)4.30439647
9ribosomal small subunit biogenesis (GO:0042274)4.26459415
10transcription elongation from RNA polymerase I promoter (GO:0006362)4.17512008
11termination of RNA polymerase I transcription (GO:0006363)4.00366495
12ribosomal small subunit assembly (GO:0000028)3.93511529
13mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.85148681
14transcription from RNA polymerase I promoter (GO:0006360)3.78223903
15DNA deamination (GO:0045006)3.71472992
16DNA damage response, detection of DNA damage (GO:0042769)3.69756715
17DNA double-strand break processing (GO:0000729)3.66960126
18viral transcription (GO:0019083)3.59262385
19deoxyribonucleoside diphosphate metabolic process (GO:0009186)3.58641512
20chaperone-mediated protein transport (GO:0072321)3.54976017
21maturation of SSU-rRNA (GO:0030490)3.54091995
22transcription initiation from RNA polymerase I promoter (GO:0006361)3.49815559
23tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.45697655
24RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.45697655
25ribosomal large subunit biogenesis (GO:0042273)3.45649772
26translational termination (GO:0006415)3.42347470
27protein complex biogenesis (GO:0070271)3.36899728
28cotranslational protein targeting to membrane (GO:0006613)3.27768032
29SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.25793718
30regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.23264655
31regulation of mitotic spindle checkpoint (GO:1903504)3.23264655
32nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.23154595
33DNA catabolic process, exonucleolytic (GO:0000738)3.22483024
34mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.22435414
35mitochondrial respiratory chain complex I assembly (GO:0032981)3.22435414
36NADH dehydrogenase complex assembly (GO:0010257)3.22435414
37peptidyl-histidine modification (GO:0018202)3.20505971
38protein targeting to ER (GO:0045047)3.19765306
39platelet dense granule organization (GO:0060155)3.19620910
40rRNA modification (GO:0000154)3.15965491
41GTP biosynthetic process (GO:0006183)3.14356805
42negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.14268327
43GPI anchor biosynthetic process (GO:0006506)3.12895806
44sequestering of actin monomers (GO:0042989)3.12840715
45L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.12664313
46translation (GO:0006412)3.11237841
47protein localization to endoplasmic reticulum (GO:0070972)3.10325971
48regulation of meiosis I (GO:0060631)3.09946371
49exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.07944968
50transcription-coupled nucleotide-excision repair (GO:0006283)3.07937559
51regulation of cellular amino acid metabolic process (GO:0006521)3.07200818
52transcription elongation from RNA polymerase II promoter (GO:0006368)3.06872295
53axon ensheathment in central nervous system (GO:0032291)3.04881256
54central nervous system myelination (GO:0022010)3.04881256
55water-soluble vitamin biosynthetic process (GO:0042364)3.03751076
56DNA-templated transcription, elongation (GO:0006354)3.01978268
57mannosylation (GO:0097502)3.00111028
58establishment of protein localization to endoplasmic reticulum (GO:0072599)2.99234246
59iron-sulfur cluster assembly (GO:0016226)2.97551290
60metallo-sulfur cluster assembly (GO:0031163)2.97551290
61cullin deneddylation (GO:0010388)2.96868825
62DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.96587993
63ribonucleoprotein complex biogenesis (GO:0022613)2.96274104
64base-excision repair, AP site formation (GO:0006285)2.95774645
65antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.95204967
66regulation of mitochondrial translation (GO:0070129)2.94841168
67positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.92303248
68aldehyde catabolic process (GO:0046185)2.91784816
69signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.91093619
70signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.91093619
71signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.91093619
72protein localization to mitochondrion (GO:0070585)2.90926764
73mitochondrial respiratory chain complex assembly (GO:0033108)2.90056373
74positive regulation of protein homodimerization activity (GO:0090073)2.89796765
75pseudouridine synthesis (GO:0001522)2.89629805
76CENP-A containing nucleosome assembly (GO:0034080)2.89281587
77inner mitochondrial membrane organization (GO:0007007)2.89188588
78cellular component biogenesis (GO:0044085)2.87664752
79signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.87593278
80intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.87593278
81negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.87407319
82negative regulation of ligase activity (GO:0051352)2.87407319
83positive regulation of viral transcription (GO:0050434)2.87211627
84deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.87104560
85spliceosomal snRNP assembly (GO:0000387)2.86188335
86presynaptic membrane assembly (GO:0097105)2.85101442
87respiratory electron transport chain (GO:0022904)2.85006248
88rRNA methylation (GO:0031167)2.84299395
89protein targeting to mitochondrion (GO:0006626)2.84292473
90histone mRNA metabolic process (GO:0008334)2.83844834
91regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.83443939
92respiratory chain complex IV assembly (GO:0008535)2.82312866
93cytochrome complex assembly (GO:0017004)2.80873134
94chromatin remodeling at centromere (GO:0031055)2.80676103
95piRNA metabolic process (GO:0034587)2.79710401
96RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.79356920
97spliceosomal complex assembly (GO:0000245)2.79154303
98long-chain fatty acid biosynthetic process (GO:0042759)2.79079837
99intracellular protein transmembrane import (GO:0044743)2.78851569
100electron transport chain (GO:0022900)2.77432671
101signal transduction involved in cell cycle checkpoint (GO:0072395)2.77417783
102signal transduction involved in DNA damage checkpoint (GO:0072422)2.76938713
103signal transduction involved in DNA integrity checkpoint (GO:0072401)2.76938713
104antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.76929017
105preassembly of GPI anchor in ER membrane (GO:0016254)2.76694864
106DNA ligation (GO:0006266)2.76269143
107protein deneddylation (GO:0000338)2.76016072
108viral life cycle (GO:0019058)2.75695136
109positive regulation of mitochondrial fission (GO:0090141)2.75617038
110positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.75585846
111translational elongation (GO:0006414)2.73168364
112cellular protein complex disassembly (GO:0043624)2.71307285
113protein-cofactor linkage (GO:0018065)2.70139608
114hydrogen ion transmembrane transport (GO:1902600)2.69999851
115centriole replication (GO:0007099)2.69974282
116single strand break repair (GO:0000012)2.69952448
117mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.69856505
118proton transport (GO:0015992)2.69294726
119intraciliary transport (GO:0042073)2.68892859
120rRNA processing (GO:0006364)2.67867900
121GPI anchor metabolic process (GO:0006505)2.66921858
122purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.65826046
123anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.65342257
124telomere maintenance via semi-conservative replication (GO:0032201)2.64597111
125deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.64421939
126hydrogen transport (GO:0006818)2.63696281
127branched-chain amino acid catabolic process (GO:0009083)2.63632427
128energy coupled proton transport, down electrochemical gradient (GO:0015985)2.63248295
129ATP synthesis coupled proton transport (GO:0015986)2.63248295
130organelle disassembly (GO:1903008)2.62741861
131establishment of protein localization to mitochondrion (GO:0072655)2.61645307
132anterograde synaptic vesicle transport (GO:0048490)2.61499744
133guanosine-containing compound biosynthetic process (GO:1901070)2.61356700
134positive regulation of ligase activity (GO:0051351)2.60039582
135translational initiation (GO:0006413)2.59604700
136tRNA processing (GO:0008033)2.59498015
137amino acid salvage (GO:0043102)2.58671545
138L-methionine salvage (GO:0071267)2.58671545
139L-methionine biosynthetic process (GO:0071265)2.58671545
140regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.58490880
141somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.57090986
142isotype switching (GO:0045190)2.57090986
143somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.57090986
144deoxyribose phosphate catabolic process (GO:0046386)2.53450496
145deoxyribonucleotide catabolic process (GO:0009264)2.53060615
146oxidative phosphorylation (GO:0006119)2.50461557

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.86626514
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.48580088
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.05220675
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.61681778
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.57578540
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.36279927
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.22421889
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.16655087
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.09816993
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.81209752
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.75260178
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.73635024
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.68820466
14ZNF274_21170338_ChIP-Seq_K562_Hela2.62897576
15ELK1_19687146_ChIP-ChIP_HELA_Human2.34999208
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.34781356
17MYC_18555785_ChIP-Seq_MESCs_Mouse2.28726784
18* VDR_23849224_ChIP-Seq_CD4+_Human2.27239446
19SRF_21415370_ChIP-Seq_HL-1_Mouse2.23686837
20TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.11234754
21BP1_19119308_ChIP-ChIP_Hs578T_Human2.03664839
22PCGF2_27294783_Chip-Seq_ESCs_Mouse2.03498230
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.01638440
24FLI1_27457419_Chip-Seq_LIVER_Mouse2.00950132
25PADI4_21655091_ChIP-ChIP_MCF-7_Human1.94861942
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.90392737
27ZFP57_27257070_Chip-Seq_ESCs_Mouse1.89538626
28YY1_21170310_ChIP-Seq_MESCs_Mouse1.87111712
29MYC_18358816_ChIP-ChIP_MESCs_Mouse1.83271417
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.71219389
31THAP11_20581084_ChIP-Seq_MESCs_Mouse1.68011432
32IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.66756078
33FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.66612630
34DCP1A_22483619_ChIP-Seq_HELA_Human1.66139405
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.64777675
36FOXP3_21729870_ChIP-Seq_TREG_Human1.63347200
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.62603373
38P300_19829295_ChIP-Seq_ESCs_Human1.62485028
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.59902808
40MYC_19030024_ChIP-ChIP_MESCs_Mouse1.57953000
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.52753039
42IRF1_19129219_ChIP-ChIP_H3396_Human1.50082109
43VDR_22108803_ChIP-Seq_LS180_Human1.48217537
44SALL1_21062744_ChIP-ChIP_HESCs_Human1.44095927
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.43124495
46TTF2_22483619_ChIP-Seq_HELA_Human1.43058203
47MYC_19079543_ChIP-ChIP_MESCs_Mouse1.42435555
48BMI1_23680149_ChIP-Seq_NPCS_Mouse1.40627228
49ELK1_22589737_ChIP-Seq_MCF10A_Human1.39710892
50IRF8_21731497_ChIP-ChIP_J774_Mouse1.38710262
51SUZ12_27294783_Chip-Seq_NPCs_Mouse1.37140266
52E2F1_18555785_ChIP-Seq_MESCs_Mouse1.36794420
53TP53_22573176_ChIP-Seq_HFKS_Human1.36746247
54CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.36636256
55TAF15_26573619_Chip-Seq_HEK293_Human1.36270301
56FUS_26573619_Chip-Seq_HEK293_Human1.35614197
57ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.32214111
58NFE2_27457419_Chip-Seq_LIVER_Mouse1.31874918
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.31098992
60EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.30545307
61* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.27657685
62FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.26317806
63POU3F2_20337985_ChIP-ChIP_501MEL_Human1.25651958
64NANOG_19829295_ChIP-Seq_ESCs_Human1.25589423
65SOX2_19829295_ChIP-Seq_ESCs_Human1.25589423
66ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.25448555
67HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.24459536
68MYC_18940864_ChIP-ChIP_HL60_Human1.24310731
69SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.21974085
70FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.21751823
71E2F4_17652178_ChIP-ChIP_JURKAT_Human1.21674374
72MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21066547
73CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.20132710
74POU5F1_16153702_ChIP-ChIP_HESCs_Human1.19927553
75ER_23166858_ChIP-Seq_MCF-7_Human1.19171549
76* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.19155108
77FOXA1_27270436_Chip-Seq_PROSTATE_Human1.18511953
78FOXA1_25329375_ChIP-Seq_VCAP_Human1.18511953
79CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.18009512
80HTT_18923047_ChIP-ChIP_STHdh_Human1.17971043
81AR_20517297_ChIP-Seq_VCAP_Human1.17527832
82PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16640778
83GBX2_23144817_ChIP-Seq_PC3_Human1.15696413
84YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15251112
85FOXA1_21572438_ChIP-Seq_LNCaP_Human1.14389110
86SUZ12_18555785_Chip-Seq_ESCs_Mouse1.13932903
87STAT3_18555785_Chip-Seq_ESCs_Mouse1.12654703
88XRN2_22483619_ChIP-Seq_HELA_Human1.12602490
89EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.12506745
90RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.11826919
91EZH2_27294783_Chip-Seq_NPCs_Mouse1.11610142
92* EWS_26573619_Chip-Seq_HEK293_Human1.11190783
93NOTCH1_21737748_ChIP-Seq_TLL_Human1.10898976
94GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09797088
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09589809
96POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08762443
97NMYC_18555785_Chip-Seq_ESCs_Mouse1.08701147
98E2F1_18555785_Chip-Seq_ESCs_Mouse1.08663691
99CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.08364663
100CBP_20019798_ChIP-Seq_JUKART_Human1.07601554
101IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07601554
102P300_18555785_Chip-Seq_ESCs_Mouse1.07071312
103EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05344427
104RUNX1_27457419_Chip-Seq_LIVER_Mouse1.05287430
105P53_22387025_ChIP-Seq_ESCs_Mouse1.03821161
106NANOG_18555785_Chip-Seq_ESCs_Mouse1.01997870
107* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.00150747
108IGF1R_20145208_ChIP-Seq_DFB_Human0.99958617
109CRX_20693478_ChIP-Seq_RETINA_Mouse0.99460511
110* GABP_19822575_ChIP-Seq_HepG2_Human0.99307845
111PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99078275
112SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98365234
113ZFX_18555785_Chip-Seq_ESCs_Mouse0.98322696
114* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.97806563
115CMYC_18555785_Chip-Seq_ESCs_Mouse0.97606448
116AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96116267
117FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95763154
118OCT4_18555785_Chip-Seq_ESCs_Mouse0.95254159
119* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.95242170
120ERG_20887958_ChIP-Seq_HPC-7_Mouse0.95200622
121MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95154429
122* CBX2_27304074_Chip-Seq_ESCs_Mouse0.93698484
123E2F7_22180533_ChIP-Seq_HELA_Human0.93540438
124SMAD1_18555785_Chip-Seq_ESCs_Mouse0.93210814
125KLF4_18555785_Chip-Seq_ESCs_Mouse0.93106164
126RNF2_27304074_Chip-Seq_NSC_Mouse0.93034803
127TAL1_26923725_Chip-Seq_HPCs_Mouse0.92281768
128SOX2_18555785_Chip-Seq_ESCs_Mouse0.92113713
129TCF4_22108803_ChIP-Seq_LS180_Human0.92023935
130EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.91802688
131BCAT_22108803_ChIP-Seq_LS180_Human0.91091946
132TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90664406
133EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.90122824
134CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.87292052
135NELFA_20434984_ChIP-Seq_ESCs_Mouse0.87189858
136NCOR_22424771_ChIP-Seq_293T_Human0.85953893
137SOX2_18555785_ChIP-Seq_MESCs_Mouse0.84490838

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation3.85978232
2MP0003136_yellow_coat_color3.63668544
3MP0006292_abnormal_olfactory_placode3.59121286
4MP0005171_absent_coat_pigmentation3.25447246
5MP0005409_darkened_coat_color2.71978229
6MP0004381_abnormal_hair_follicle2.71831586
7MP0001188_hyperpigmentation2.65932778
8MP0003880_abnormal_central_pattern2.36702885
9MP0008995_early_reproductive_senescence2.29704669
10MP0006036_abnormal_mitochondrial_physio2.28006188
11MP0003195_calcinosis2.25493883
12MP0000372_irregular_coat_pigmentation2.18279440
13MP0001986_abnormal_taste_sensitivity2.10050788
14MP0003693_abnormal_embryo_hatching2.05758379
15MP0001905_abnormal_dopamine_level2.05135839
16MP0005084_abnormal_gallbladder_morpholo2.03339019
17MP0008058_abnormal_DNA_repair2.00826132
18MP0003567_abnormal_fetal_cardiomyocyte1.93905539
19MP0005075_abnormal_melanosome_morpholog1.91103325
20MP0001764_abnormal_homeostasis1.90622853
21MP0003806_abnormal_nucleotide_metabolis1.88010787
22MP0002638_abnormal_pupillary_reflex1.87735708
23MP0002277_abnormal_respiratory_mucosa1.87535411
24MP0001529_abnormal_vocalization1.87113594
25MP0008057_abnormal_DNA_replication1.85536775
26MP0002148_abnormal_hypersensitivity_rea1.84324898
27MP0000015_abnormal_ear_pigmentation1.83033188
28MP0003718_maternal_effect1.81626092
29MP0003724_increased_susceptibility_to1.81109702
30MP0000566_synostosis1.80119473
31MP0005646_abnormal_pituitary_gland1.74143656
32MP0008875_abnormal_xenobiotic_pharmacok1.72670641
33MP0005671_abnormal_response_to1.65875050
34MP0009785_altered_susceptibility_to1.61754267
35MP0000516_abnormal_urinary_system1.61086729
36MP0005367_renal/urinary_system_phenotyp1.61086729
37MP0001835_abnormal_antigen_presentation1.60121765
38MP0005408_hypopigmentation1.53749349
39MP0008932_abnormal_embryonic_tissue1.50673761
40MP0002938_white_spotting1.47602371
41MP0005645_abnormal_hypothalamus_physiol1.45854000
42MP0008872_abnormal_physiological_respon1.44787853
43MP0002163_abnormal_gland_morphology1.44678461
44MP0003186_abnormal_redox_activity1.44026047
45MP0002876_abnormal_thyroid_physiology1.42894857
46MP0003121_genomic_imprinting1.41285613
47MP0002837_dystrophic_cardiac_calcinosis1.41004274
48MP0002095_abnormal_skin_pigmentation1.39672559
49MP0002132_abnormal_respiratory_system1.38290197
50MP0003786_premature_aging1.37428675
51MP0003315_abnormal_perineum_morphology1.35808247
52MP0000920_abnormal_myelination1.35242386
53MP0005174_abnormal_tail_pigmentation1.30924764
54MP0005085_abnormal_gallbladder_physiolo1.29056859
55MP0009046_muscle_twitch1.29043710
56MP0004142_abnormal_muscle_tone1.28238902
57MP0003938_abnormal_ear_development1.27000901
58MP0004957_abnormal_blastocyst_morpholog1.26815056
59MP0009333_abnormal_splenocyte_physiolog1.25911643
60MP0008260_abnormal_autophagy1.25515900
61MP0002102_abnormal_ear_morphology1.23441710
62MP0000569_abnormal_digit_pigmentation1.19234106
63MP0001485_abnormal_pinna_reflex1.18382391
64MP0003122_maternal_imprinting1.16167068
65MP0000681_abnormal_thyroid_gland1.15418672
66MP0002751_abnormal_autonomic_nervous1.15309597
67MP0003787_abnormal_imprinting1.14829420
68MP0002234_abnormal_pharynx_morphology1.14535886
69MP0006276_abnormal_autonomic_nervous1.13934509
70MP0006035_abnormal_mitochondrial_morpho1.12702972
71MP0001919_abnormal_reproductive_system1.11477939
72MP0000631_abnormal_neuroendocrine_gland1.11345141
73MP0005389_reproductive_system_phenotype1.10703865
74MP0002160_abnormal_reproductive_system1.10399383
75MP0001293_anophthalmia1.08766668
76MP0001929_abnormal_gametogenesis1.08471088
77MP0001542_abnormal_bone_strength1.08323121
78MP0009697_abnormal_copulation1.08104575
79MP0004742_abnormal_vestibular_system1.07128504
80MP0005000_abnormal_immune_tolerance1.06770727
81MP0008789_abnormal_olfactory_epithelium1.04665977
82MP0004885_abnormal_endolymph1.02767987
83MP0010094_abnormal_chromosome_stability1.01691355
84MP0000653_abnormal_sex_gland1.00269235
85MP0005025_abnormal_response_to0.99367419
86MP0005423_abnormal_somatic_nervous0.97744770
87MP0002272_abnormal_nervous_system0.97298229
88MP0005379_endocrine/exocrine_gland_phen0.96564764
89MP0002723_abnormal_immune_serum0.96297801
90MP0005310_abnormal_salivary_gland0.96211152
91MP0001486_abnormal_startle_reflex0.95834780
92MP0001145_abnormal_male_reproductive0.95511515
93MP0003252_abnormal_bile_duct0.94481627
94MP0003950_abnormal_plasma_membrane0.94009774
95MP0004133_heterotaxia0.93319978
96MP0003011_delayed_dark_adaptation0.93136670
97MP0005253_abnormal_eye_physiology0.92506017
98MP0005332_abnormal_amino_acid0.91978840
99MP0005636_abnormal_mineral_homeostasis0.90712419
100MP0009764_decreased_sensitivity_to0.90224210
101MP0002420_abnormal_adaptive_immunity0.90179154
102MP0000049_abnormal_middle_ear0.89596746
103MP0001800_abnormal_humoral_immune0.89519883
104MP0001819_abnormal_immune_cell0.89161567
105MP0000026_abnormal_inner_ear0.89123700
106MP0005387_immune_system_phenotype0.88737018
107MP0001790_abnormal_immune_system0.88737018
108MP0001346_abnormal_lacrimal_gland0.88527818
109MP0002452_abnormal_antigen_presenting0.87081705
110MP0003077_abnormal_cell_cycle0.86457819
111MP0002736_abnormal_nociception_after0.85151049
112MP0008007_abnormal_cellular_replicative0.84812103
113MP0005551_abnormal_eye_electrophysiolog0.84617824
114MP0004043_abnormal_pH_regulation0.84614068
115MP0003763_abnormal_thymus_physiology0.84313845
116MP0001963_abnormal_hearing_physiology0.84055882
117MP0002419_abnormal_innate_immunity0.83756431
118MP0002735_abnormal_chemical_nociception0.82830263
119MP0004147_increased_porphyrin_level0.82218484
120MP0002177_abnormal_outer_ear0.81496607
121MP0005365_abnormal_bile_salt0.80450557
122MP0003698_abnormal_male_reproductive0.80279142
123MP0000778_abnormal_nervous_system0.79354997
124MP0008877_abnormal_DNA_methylation0.78958996
125MP0001119_abnormal_female_reproductive0.78043892
126MP0001853_heart_inflammation0.77564235
127MP0000613_abnormal_salivary_gland0.77465414
128MP0001984_abnormal_olfaction0.75649374
129MP0001968_abnormal_touch/_nociception0.74645109
130MP0002210_abnormal_sex_determination0.74575208
131MP0002752_abnormal_somatic_nervous0.73953922
132MP0010386_abnormal_urinary_bladder0.72662866
133MP0001501_abnormal_sleep_pattern0.72275973
134MP0009765_abnormal_xenobiotic_induced0.71861389
135MP0002282_abnormal_trachea_morphology0.71208304
136MP0006072_abnormal_retinal_apoptosis0.70163142
137MP0002233_abnormal_nose_morphology0.69272900
138MP0002734_abnormal_mechanical_nocicepti0.68413782
139MP0005410_abnormal_fertilization0.67901415
140MP0010329_abnormal_lipoprotein_level0.67648307
141MP0001666_abnormal_nutrient_absorption0.65866860
142MP0002229_neurodegeneration0.63561942
143MP0008873_increased_physiological_sensi0.61568087
144MP0002822_catalepsy0.60883638
145MP0000427_abnormal_hair_cycle0.60825280

Predicted human phenotypes

RankGene SetZ-score
1Increased IgM level (HP:0003496)4.66071604
2Breast hypoplasia (HP:0003187)4.61885339
3Abnormality of incisor morphology (HP:0011063)3.69887508
4Conical tooth (HP:0000698)3.69203735
5Acute necrotizing encephalopathy (HP:0006965)3.65526899
6Mitochondrial inheritance (HP:0001427)3.37034774
7Methylmalonic acidemia (HP:0002912)3.27751805
8Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.22532970
9Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.19944752
10Abnormality of midbrain morphology (HP:0002418)3.13207502
11Molar tooth sign on MRI (HP:0002419)3.13207502
12Parakeratosis (HP:0001036)3.12768181
13Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.09963254
143-Methylglutaconic aciduria (HP:0003535)3.08397773
15Renal cortical cysts (HP:0000803)3.06671578
16Progressive macrocephaly (HP:0004481)3.03518574
17Abnormal mitochondria in muscle tissue (HP:0008316)3.03495061
18Thick nail (HP:0001805)3.02473478
19Type I transferrin isoform profile (HP:0003642)2.99117613
20Increased hepatocellular lipid droplets (HP:0006565)2.98385783
21Reticulocytopenia (HP:0001896)2.96607131
22Eosinophilia (HP:0001880)2.96139966
23Renal Fanconi syndrome (HP:0001994)2.95416219
24Hepatocellular necrosis (HP:0001404)2.91210616
25Bile duct proliferation (HP:0001408)2.83980590
26Abnormal biliary tract physiology (HP:0012439)2.83980590
27Cerebral edema (HP:0002181)2.80101485
28Granulocytopenia (HP:0001913)2.79047569
29Increased CSF lactate (HP:0002490)2.76661890
30Increased intramyocellular lipid droplets (HP:0012240)2.74843666
31Absent hand (HP:0004050)2.73529128
32Acute encephalopathy (HP:0006846)2.71971275
33Aplasia/hypoplasia of the uterus (HP:0008684)2.68739884
34Methylmalonic aciduria (HP:0012120)2.62810107
35Nephronophthisis (HP:0000090)2.59546336
36Abnormality of cells of the erythroid lineage (HP:0012130)2.57925981
37True hermaphroditism (HP:0010459)2.57630299
38Congenital stationary night blindness (HP:0007642)2.56595498
39Ridged nail (HP:0001807)2.55774325
40Abnormality of the renal cortex (HP:0011035)2.52996457
41Abnormality of eosinophils (HP:0001879)2.51489570
42Lipid accumulation in hepatocytes (HP:0006561)2.47460440
43Lactic acidosis (HP:0003128)2.46621994
44Abnormal number of erythroid precursors (HP:0012131)2.43362464
45Supernumerary bones of the axial skeleton (HP:0009144)2.43226341
46Optic disc pallor (HP:0000543)2.42512400
47Cerebral hypomyelination (HP:0006808)2.39230938
48Patchy hypopigmentation of hair (HP:0011365)2.38762250
49Abolished electroretinogram (ERG) (HP:0000550)2.37889308
50IgG deficiency (HP:0004315)2.34317827
51Pancreatic cysts (HP:0001737)2.29329168
52Aplasia/Hypoplasia of the sacrum (HP:0008517)2.28828170
53Hepatic necrosis (HP:0002605)2.28442809
54Pancreatic fibrosis (HP:0100732)2.26651802
55Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.26348757
56Abnormal protein N-linked glycosylation (HP:0012347)2.26348757
57Abnormal protein glycosylation (HP:0012346)2.26348757
58Abnormal glycosylation (HP:0012345)2.26348757
59Macrocytic anemia (HP:0001972)2.25590123
60Abnormality of the renal medulla (HP:0100957)2.25480993
61Chromosomal breakage induced by crosslinking agents (HP:0003221)2.23738444
62Increased muscle lipid content (HP:0009058)2.23383592
63Supernumerary ribs (HP:0005815)2.22143685
64Abnormality of secondary sexual hair (HP:0009888)2.21926436
65Abnormality of the axillary hair (HP:0100134)2.21926436
66Hyperglycinemia (HP:0002154)2.21164913
67Medial flaring of the eyebrow (HP:0010747)2.20469600
68Exertional dyspnea (HP:0002875)2.19420176
69Abnormality of vitamin B metabolism (HP:0004340)2.19324078
70Congenital ichthyosiform erythroderma (HP:0007431)2.19137667
71Abnormality of the vitamin B12 metabolism (HP:0004341)2.15686628
72Abnormality of urine glucose concentration (HP:0011016)2.15330962
73Glycosuria (HP:0003076)2.15330962
74Aplasia/Hypoplasia involving the musculature (HP:0001460)2.15093447
75Duplicated collecting system (HP:0000081)2.14279573
76Abnormality of the renal collecting system (HP:0004742)2.13692334
77Reduced antithrombin III activity (HP:0001976)2.13643859
78Lethargy (HP:0001254)2.13120290
79Tubulointerstitial nephritis (HP:0001970)2.12167452
80Abnormality of renal resorption (HP:0011038)2.11042117
81Generalized aminoaciduria (HP:0002909)2.10200240
82Congenital primary aphakia (HP:0007707)2.09779142
83IgA deficiency (HP:0002720)2.08871971
84Male pseudohermaphroditism (HP:0000037)2.07929066
85Hypoplasia of the uterus (HP:0000013)2.07907082
86Hypoplastic nipples (HP:0002557)2.04764178
87Abnormality of aspartate family amino acid metabolism (HP:0010899)2.04761629
88Dicarboxylic aciduria (HP:0003215)2.04053529
89Abnormality of dicarboxylic acid metabolism (HP:0010995)2.04053529
90White forelock (HP:0002211)2.02857496
91Dynein arm defect of respiratory motile cilia (HP:0012255)2.01636440
92Absent/shortened dynein arms (HP:0200106)2.01636440
93Adrenal hypoplasia (HP:0000835)2.01058520
94Increased serum lactate (HP:0002151)2.00224191
95Colon cancer (HP:0003003)2.00155962
96Gait imbalance (HP:0002141)1.99075467
97Progressive external ophthalmoplegia (HP:0000590)1.98463244
98Aplastic anemia (HP:0001915)1.98127771
99Hypothermia (HP:0002045)1.96281685
100Exercise intolerance (HP:0003546)1.95697011
101Absent rod-and cone-mediated responses on ERG (HP:0007688)1.95600438
102Encephalitis (HP:0002383)1.94224399
103Pallor (HP:0000980)1.93761942
104Erythema (HP:0010783)1.93549401
105Abnormality of the incisor (HP:0000676)1.93312980
106Abnormality of the labia minora (HP:0012880)1.91411079
107Chromsome breakage (HP:0040012)1.90946957
108Septo-optic dysplasia (HP:0100842)1.90679500
109Abnormal hair whorl (HP:0010721)1.90151584
110Birth length less than 3rd percentile (HP:0003561)1.90023894
111Leukodystrophy (HP:0002415)1.89733450
112CNS demyelination (HP:0007305)1.89433573
113Abnormality of the septum pellucidum (HP:0007375)1.86507002
114Abnormality of placental membranes (HP:0011409)1.85198375
115Amniotic constriction ring (HP:0009775)1.85198375
116Split foot (HP:0001839)1.82808878
117Abnormal respiratory epithelium morphology (HP:0012253)1.82798472
118Abnormal respiratory motile cilium morphology (HP:0005938)1.82798472
119Sclerocornea (HP:0000647)1.82566657
120Hypoglycemic coma (HP:0001325)1.82561526
121Stenosis of the external auditory canal (HP:0000402)1.82461522
122Meckel diverticulum (HP:0002245)1.82417015
123Respiratory failure (HP:0002878)1.82124351
124Severe combined immunodeficiency (HP:0004430)1.81906940
125Hyperphosphaturia (HP:0003109)1.81646271
126Abnormality of methionine metabolism (HP:0010901)1.79950616
127Cleft eyelid (HP:0000625)1.78910450
128Pancytopenia (HP:0001876)1.77854866
129Type 2 muscle fiber atrophy (HP:0003554)1.77661599
130Aplasia/Hypoplasia of the tongue (HP:0010295)1.77481440
131Abnormal ciliary motility (HP:0012262)1.76822372
132Nephrogenic diabetes insipidus (HP:0009806)1.76325777
133Decreased activity of mitochondrial respiratory chain (HP:0008972)1.75943757
134Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.75943757
135Chronic hepatic failure (HP:0100626)1.75875308
136Triphalangeal thumb (HP:0001199)1.74386574
137Genital tract atresia (HP:0001827)1.74071699
138Abnormality of the ileum (HP:0001549)1.73240269
139Congenital, generalized hypertrichosis (HP:0004540)1.73171606
140Carpal bone hypoplasia (HP:0001498)1.72924102
141Abnormality of chromosome stability (HP:0003220)1.72865520
142Abnormality of the preputium (HP:0100587)1.72373979
143Thyroiditis (HP:0100646)1.72185511
144Congenital sensorineural hearing impairment (HP:0008527)1.71486025
145Ketoacidosis (HP:0001993)1.71025083
146Leukocytosis (HP:0001974)1.70919079
147Respiratory difficulties (HP:0002880)1.68884249
148Stomatitis (HP:0010280)1.68692059
149Gonadotropin excess (HP:0000837)1.67000855
150Postaxial foot polydactyly (HP:0001830)1.65766469
151Vaginal atresia (HP:0000148)1.65080186
152Hypoproteinemia (HP:0003075)1.64527073
153Bifid tongue (HP:0010297)1.64408122
154Abnormality of serum amino acid levels (HP:0003112)1.63914758
155Short tibia (HP:0005736)1.63904397
156Panhypogammaglobulinemia (HP:0003139)1.62997873
157Abnormality of B cell number (HP:0010975)1.59310722
158Delayed CNS myelination (HP:0002188)1.59152076

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK3.48648230
2MAP4K23.35726235
3STK163.26192824
4CASK3.22913133
5VRK23.10863479
6IRAK32.70093615
7EIF2AK32.64784973
8SRPK12.61412475
9IRAK42.46892328
10EIF2AK12.39070332
11WNK32.21561987
12FRK2.19136177
13TLK12.15976351
14NME22.15604644
15PBK2.14525111
16MST42.07587938
17VRK12.04144969
18MKNK22.00055458
19BUB11.91859339
20TRIM281.91399437
21PRPF4B1.80462094
22BMPR1B1.72173528
23TAOK31.71383778
24BCR1.67483463
25MKNK11.64697335
26IRAK21.62539745
27PLK41.61932569
28MUSK1.59675300
29NEK61.58386503
30TXK1.56577028
31IKBKB1.53749956
32BCKDK1.52371609
33EIF2AK21.51504150
34ZAK1.50735381
35IRAK11.44000922
36STK391.40312515
37NLK1.39832643
38BRSK21.30962882
39MAP3K41.30168325
40YES11.29903254
41NME11.26058674
42CLK11.25689719
43ACVR1B1.24243215
44DYRK21.23615785
45BMPR21.23308893
46PIM21.18248548
47WEE11.18083489
48ADRBK21.17721483
49AKT31.14020820
50OXSR11.11361486
51MAPK131.04798648
52MAP3K141.04228210
53MAP3K121.01782034
54TAF11.01515462
55PKN10.98852989
56GRK70.91646130
57CSNK1G20.86580148
58TEC0.84653940
59PASK0.82789443
60CAMKK20.82765064
61IKBKE0.82642855
62NEK10.80310763
63CCNB10.78850111
64TSSK60.78676724
65INSRR0.78147083
66CDK190.76806730
67PINK10.76136629
68GRK10.75072969
69BRAF0.73529642
70SCYL20.73196134
71PLK30.72145358
72LIMK10.71204317
73MAP2K70.70761615
74NUAK10.70130041
75MAP3K50.65690573
76ARAF0.64603731
77CDC70.64453760
78PLK20.63447223
79FES0.63252419
80MINK10.63206996
81RPS6KA50.62914538
82CAMK2B0.61412831
83PAK30.60936093
84KDR0.58577218
85STK38L0.57745774
86ABL20.56159316
87MYLK0.55947202
88CDK80.55934906
89LYN0.55807586
90GRK50.54725294
91CSNK1G30.53706095
92CDK30.52585301
93CSNK2A10.51800564
94TESK20.50062262
95ITK0.49830354
96BLK0.48458809
97MAPKAPK50.47988870
98PRKCG0.47327160
99ATR0.46580921
100GRK60.46553469
101PRKCE0.46403243
102DAPK10.45890111
103RPS6KA40.45288748
104MARK10.45270030
105ATM0.44089861
106PRKCQ0.43620176
107PLK10.42985801
108CSNK1G10.42860366
109AURKA0.42734806
110KIT0.42639475
111NEK90.41309570
112EPHA40.40184039
113ADRBK10.39792507
114BRSK10.38847056
115MAP2K60.38121677
116CSNK2A20.38012967
117ERBB30.37007553
118PRKCI0.36887789
119DYRK30.34203294
120CSNK1A1L0.33726032
121STK40.33620612
122CAMK2D0.32532801
123UHMK10.32140545
124MARK30.31971980
125CAMK2G0.31828073
126PRKACA0.31489268
127TNK20.30875224
128RIPK40.30071174
129MAP2K40.30067615
130LCK0.29819715
131PNCK0.29140301
132PIM10.28251500
133OBSCN0.27159506
134CDK70.27061580
135TTK0.26595984
136TIE10.26581340
137CSNK1A10.25992228
138PIK3CA0.25936917
139AURKB0.25717677

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.26223813
2RNA polymerase_Homo sapiens_hsa030204.12627322
3Proteasome_Homo sapiens_hsa030503.83772801
4Oxidative phosphorylation_Homo sapiens_hsa001903.23929620
5Protein export_Homo sapiens_hsa030602.95691967
6Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.81113817
7Parkinsons disease_Homo sapiens_hsa050122.54396769
8Basal transcription factors_Homo sapiens_hsa030222.42803530
9Pyrimidine metabolism_Homo sapiens_hsa002402.25226276
10Homologous recombination_Homo sapiens_hsa034402.19375641
11DNA replication_Homo sapiens_hsa030302.15566426
12Propanoate metabolism_Homo sapiens_hsa006402.09515620
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.07886892
14Huntingtons disease_Homo sapiens_hsa050162.05456688
15Spliceosome_Homo sapiens_hsa030402.03207513
16Mismatch repair_Homo sapiens_hsa034301.94161253
17Alzheimers disease_Homo sapiens_hsa050101.82063116
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.78195557
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.77246426
20Nucleotide excision repair_Homo sapiens_hsa034201.76243550
21Fanconi anemia pathway_Homo sapiens_hsa034601.73856349
22Butanoate metabolism_Homo sapiens_hsa006501.62707397
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.62660840
24Primary immunodeficiency_Homo sapiens_hsa053401.62200869
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.61013323
26Allograft rejection_Homo sapiens_hsa053301.60166341
27SNARE interactions in vesicular transport_Homo sapiens_hsa041301.58857073
28Sphingolipid metabolism_Homo sapiens_hsa006001.45214925
29Purine metabolism_Homo sapiens_hsa002301.45050397
30Autoimmune thyroid disease_Homo sapiens_hsa053201.36954837
31Graft-versus-host disease_Homo sapiens_hsa053321.34777254
32Peroxisome_Homo sapiens_hsa041461.28099904
33Fatty acid elongation_Homo sapiens_hsa000621.26971379
34Steroid biosynthesis_Homo sapiens_hsa001001.24974012
35Rheumatoid arthritis_Homo sapiens_hsa053231.21718677
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.21064758
37Collecting duct acid secretion_Homo sapiens_hsa049661.17243848
38Asthma_Homo sapiens_hsa053101.16888987
39Base excision repair_Homo sapiens_hsa034101.14940002
40Ether lipid metabolism_Homo sapiens_hsa005651.14888151
41Phototransduction_Homo sapiens_hsa047441.14700343
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.14284593
43Chemical carcinogenesis_Homo sapiens_hsa052041.10671309
44Intestinal immune network for IgA production_Homo sapiens_hsa046721.10508332
45Arachidonic acid metabolism_Homo sapiens_hsa005901.10474079
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.09701480
47Non-homologous end-joining_Homo sapiens_hsa034501.09070473
48Tryptophan metabolism_Homo sapiens_hsa003801.08849190
49Nitrogen metabolism_Homo sapiens_hsa009101.08228481
50RNA degradation_Homo sapiens_hsa030181.07107147
51RNA transport_Homo sapiens_hsa030131.02496725
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.01441874
53Pentose and glucuronate interconversions_Homo sapiens_hsa000401.00326500
54NOD-like receptor signaling pathway_Homo sapiens_hsa046210.99838183
55Primary bile acid biosynthesis_Homo sapiens_hsa001200.94829162
56Epstein-Barr virus infection_Homo sapiens_hsa051690.94692529
57NF-kappa B signaling pathway_Homo sapiens_hsa040640.92834262
58Regulation of autophagy_Homo sapiens_hsa041400.92204885
59Caffeine metabolism_Homo sapiens_hsa002320.90652168
60Selenocompound metabolism_Homo sapiens_hsa004500.88136245
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.86404277
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82413129
63Vitamin digestion and absorption_Homo sapiens_hsa049770.81887532
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.81787505
65RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.78716001
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78411327
67Pyruvate metabolism_Homo sapiens_hsa006200.76066774
68Fatty acid degradation_Homo sapiens_hsa000710.74303073
69Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.71910415
70Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71281914
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.69279538
72Vitamin B6 metabolism_Homo sapiens_hsa007500.69062889
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68884117
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.68855905
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.68749192
76Cardiac muscle contraction_Homo sapiens_hsa042600.64649301
77Measles_Homo sapiens_hsa051620.64105011
78Vibrio cholerae infection_Homo sapiens_hsa051100.63869520
79Cysteine and methionine metabolism_Homo sapiens_hsa002700.63565224
80Herpes simplex infection_Homo sapiens_hsa051680.63560696
81Cell cycle_Homo sapiens_hsa041100.63325207
82Linoleic acid metabolism_Homo sapiens_hsa005910.62521785
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62199483
84Glutathione metabolism_Homo sapiens_hsa004800.61852207
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59200890
86beta-Alanine metabolism_Homo sapiens_hsa004100.58184807
87Hematopoietic cell lineage_Homo sapiens_hsa046400.57252176
88Folate biosynthesis_Homo sapiens_hsa007900.55661288
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54982109
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52407648
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51698330
92Phagosome_Homo sapiens_hsa041450.51671741
93Metabolic pathways_Homo sapiens_hsa011000.51538392
94Fatty acid metabolism_Homo sapiens_hsa012120.51061695
95Fat digestion and absorption_Homo sapiens_hsa049750.48242118
96Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47874098
97Serotonergic synapse_Homo sapiens_hsa047260.46113056
98Sulfur metabolism_Homo sapiens_hsa009200.43833224
99p53 signaling pathway_Homo sapiens_hsa041150.40239186
100Nicotine addiction_Homo sapiens_hsa050330.40026389
101Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.38607712
102Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38450804
103Other glycan degradation_Homo sapiens_hsa005110.38334556
104Taste transduction_Homo sapiens_hsa047420.36330397
105Toll-like receptor signaling pathway_Homo sapiens_hsa046200.35239308
106alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.35222758
107Malaria_Homo sapiens_hsa051440.34378716
108Histidine metabolism_Homo sapiens_hsa003400.34093768
109Type I diabetes mellitus_Homo sapiens_hsa049400.33882170
110mRNA surveillance pathway_Homo sapiens_hsa030150.30249472
111Oocyte meiosis_Homo sapiens_hsa041140.28178239
112Shigellosis_Homo sapiens_hsa051310.26913151
113Olfactory transduction_Homo sapiens_hsa047400.25901672
114Jak-STAT signaling pathway_Homo sapiens_hsa046300.24969435
115Steroid hormone biosynthesis_Homo sapiens_hsa001400.23873211
116Systemic lupus erythematosus_Homo sapiens_hsa053220.23791274
117T cell receptor signaling pathway_Homo sapiens_hsa046600.23024869
118N-Glycan biosynthesis_Homo sapiens_hsa005100.22613588
119Retinol metabolism_Homo sapiens_hsa008300.22382319
120Pertussis_Homo sapiens_hsa051330.21713028
121Antigen processing and presentation_Homo sapiens_hsa046120.20788471
122Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.20322091
123Hepatitis C_Homo sapiens_hsa051600.19995564
124Prostate cancer_Homo sapiens_hsa052150.18853208
125Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.18663693
126Apoptosis_Homo sapiens_hsa042100.18386900
127Acute myeloid leukemia_Homo sapiens_hsa052210.16985530
128Axon guidance_Homo sapiens_hsa043600.16867819
129Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.16412904
130Leishmaniasis_Homo sapiens_hsa051400.16262938
131One carbon pool by folate_Homo sapiens_hsa006700.15760343
132Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.12811653
133Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.12001469

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