EARS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of glutamate to tRNA molecules. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency 12 (COXPD12). Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.51178757
2ribosomal large subunit biogenesis (GO:0042273)5.02667729
3ribosomal small subunit assembly (GO:0000028)4.49481264
4maturation of SSU-rRNA (GO:0030490)4.47326372
5regulation of telomere maintenance via telomerase (GO:0032210)4.41043548
6regulation of translational fidelity (GO:0006450)4.36612226
7glycine metabolic process (GO:0006544)4.24371300
8nucleobase biosynthetic process (GO:0046112)4.20280001
9nuclear pore complex assembly (GO:0051292)4.06576206
10purine nucleobase biosynthetic process (GO:0009113)3.99266265
11maturation of 5.8S rRNA (GO:0000460)3.99210855
12viral transcription (GO:0019083)3.96374454
13folic acid metabolic process (GO:0046655)3.95466546
14ribonucleoprotein complex biogenesis (GO:0022613)3.94933921
15translational termination (GO:0006415)3.89315340
16proteasome assembly (GO:0043248)3.86181650
17folic acid-containing compound biosynthetic process (GO:0009396)3.83285750
18nuclear pore organization (GO:0006999)3.82928146
19negative regulation of gene silencing (GO:0060969)3.78011702
20ribosomal small subunit biogenesis (GO:0042274)3.75901081
21ribosome biogenesis (GO:0042254)3.72550000
22translational elongation (GO:0006414)3.68881681
23IMP biosynthetic process (GO:0006188)3.67140613
24somatic diversification of immune receptors via somatic mutation (GO:0002566)3.65104575
25somatic hypermutation of immunoglobulin genes (GO:0016446)3.65104575
26formation of translation preinitiation complex (GO:0001731)3.51556662
27pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)3.50931803
28nucleoside salvage (GO:0043174)3.49748031
29* tRNA aminoacylation for protein translation (GO:0006418)3.46001337
30pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)3.41981113
31UMP biosynthetic process (GO:0006222)3.41981113
32pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)3.41981113
33UMP metabolic process (GO:0046049)3.41981113
34* amino acid activation (GO:0043038)3.40677017
35* tRNA aminoacylation (GO:0043039)3.40677017
36establishment of integrated proviral latency (GO:0075713)3.40056103
37ribosome assembly (GO:0042255)3.39782700
38pteridine-containing compound biosynthetic process (GO:0042559)3.39604621
39DNA unwinding involved in DNA replication (GO:0006268)3.39358957
40SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.36522793
41translational initiation (GO:0006413)3.33348146
42serine family amino acid catabolic process (GO:0009071)3.31264980
43DNA replication-dependent nucleosome organization (GO:0034723)3.29961469
44DNA replication-dependent nucleosome assembly (GO:0006335)3.29961469
45peptidyl-arginine N-methylation (GO:0035246)3.26850481
46peptidyl-arginine methylation (GO:0018216)3.26850481
47DNA strand elongation involved in DNA replication (GO:0006271)3.26165562
48cotranslational protein targeting to membrane (GO:0006613)3.25070819
49protein targeting to ER (GO:0045047)3.24989388
50regulation of mitochondrial translation (GO:0070129)3.24295714
51pyrimidine-containing compound salvage (GO:0008655)3.23686151
52pyrimidine nucleoside salvage (GO:0043097)3.23686151
53gap junction assembly (GO:0016264)3.20132672
54erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.19720501
55L-phenylalanine metabolic process (GO:0006558)3.19720501
56rRNA modification (GO:0000154)3.19073484
57negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.14889820
58rRNA processing (GO:0006364)3.14854369
59pore complex assembly (GO:0046931)3.14036644
60pyrimidine nucleoside monophosphate metabolic process (GO:0009129)3.13036908
61protein complex localization (GO:0031503)3.12574700
62nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.10121697
63protein localization to endoplasmic reticulum (GO:0070972)3.07884383
64IMP metabolic process (GO:0046040)3.07825209
65establishment of protein localization to endoplasmic reticulum (GO:0072599)3.07351485
66DNA strand elongation (GO:0022616)3.06479587
67pseudouridine synthesis (GO:0001522)3.06268474
68serine family amino acid biosynthetic process (GO:0009070)3.05036305
69DNA replication initiation (GO:0006270)3.04712356
70serine family amino acid metabolic process (GO:0009069)3.04695845
71protein localization to chromosome, centromeric region (GO:0071459)3.04601929
72rRNA metabolic process (GO:0016072)3.03786464
73mitotic metaphase plate congression (GO:0007080)3.03673545
74nucleotide salvage (GO:0043173)3.01040971
75DNA strand renaturation (GO:0000733)2.98276082
76regulation of centriole replication (GO:0046599)2.97577356
77regulation of translational elongation (GO:0006448)2.97128003
78cellular protein complex disassembly (GO:0043624)2.96210037
79cellular component biogenesis (GO:0044085)2.95669678
80viral life cycle (GO:0019058)2.92085896
81folic acid-containing compound metabolic process (GO:0006760)2.91991317
82telomere maintenance via semi-conservative replication (GO:0032201)2.91889246
83biotin metabolic process (GO:0006768)2.88709137
84mitotic sister chromatid segregation (GO:0000070)2.88548127
85tetrahydrofolate metabolic process (GO:0046653)2.87883386
86presynaptic membrane organization (GO:0097090)2.86628005
87L-phenylalanine catabolic process (GO:0006559)2.85886410
88erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.85886410
89lysine catabolic process (GO:0006554)2.84555587
90lysine metabolic process (GO:0006553)2.84555587
91spliceosomal tri-snRNP complex assembly (GO:0000244)2.84405770
92spliceosomal snRNP assembly (GO:0000387)2.84200827
93aspartate family amino acid catabolic process (GO:0009068)2.83404036
94pteridine-containing compound metabolic process (GO:0042558)2.83071976
95L-serine metabolic process (GO:0006563)2.81998909
96proline metabolic process (GO:0006560)2.81498459
97viral mRNA export from host cell nucleus (GO:0046784)2.80505409
98DNA duplex unwinding (GO:0032508)2.79647792
99negative regulation of mRNA processing (GO:0050686)2.79471230
100translation (GO:0006412)2.79053110
101DNA replication checkpoint (GO:0000076)2.78208524
102double-strand break repair via nonhomologous end joining (GO:0006303)2.77015976
103non-recombinational repair (GO:0000726)2.77015976
104mitotic sister chromatid cohesion (GO:0007064)2.76736484
105positive regulation of viral genome replication (GO:0045070)2.75925522
106DNA geometric change (GO:0032392)2.75261102
107peptidyl-arginine omega-N-methylation (GO:0035247)2.75250087
108nuclear envelope disassembly (GO:0051081)2.74471079
109membrane disassembly (GO:0030397)2.74471079
110synapsis (GO:0007129)2.72652483
111glutamine metabolic process (GO:0006541)2.72518539
112mitotic nuclear envelope disassembly (GO:0007077)2.72460137
113telomere maintenance via recombination (GO:0000722)2.71673006
114regulation of chromatin silencing (GO:0031935)2.70368351
115metaphase plate congression (GO:0051310)2.67712880
116regulation of transcription from RNA polymerase I promoter (GO:0006356)2.65577405
117regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.65161652
118anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.64927420
119peptidyl-histidine modification (GO:0018202)2.64798636
120negative regulation of chromosome segregation (GO:0051985)2.64587262
121proline biosynthetic process (GO:0006561)2.64499368
122heterochromatin organization (GO:0070828)2.64440410
123histone arginine methylation (GO:0034969)2.63982369
124pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.63396859
125protein complex disassembly (GO:0043241)2.63337518
126negative regulation of mitotic sister chromatid separation (GO:2000816)2.63001346
127negative regulation of mitotic sister chromatid segregation (GO:0033048)2.63001346
128negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.63001346
129negative regulation of sister chromatid segregation (GO:0033046)2.63001346
130base-excision repair (GO:0006284)2.61301167
131* mitochondrial RNA metabolic process (GO:0000959)2.61138022
132mitotic spindle assembly checkpoint (GO:0007094)2.61069414
133mitotic chromosome condensation (GO:0007076)2.60923595
134regulation of centrosome cycle (GO:0046605)2.60780368
135sister chromatid segregation (GO:0000819)2.60739294
136homocysteine metabolic process (GO:0050667)2.59420081
137glyoxylate metabolic process (GO:0046487)2.59029509
138pre-miRNA processing (GO:0031054)2.59006360
139mitochondrial DNA metabolic process (GO:0032042)2.58212806
140tRNA methylation (GO:0030488)2.57234615
141protein localization to kinetochore (GO:0034501)2.56034682
142spindle assembly checkpoint (GO:0071173)2.55894892
143telomere maintenance via telomere lengthening (GO:0010833)2.55261304
144rRNA transcription (GO:0009303)2.54960370
145meiotic chromosome segregation (GO:0045132)2.54433600
146negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.54283389
147mitotic recombination (GO:0006312)2.54265631
148regulation of posttranscriptional gene silencing (GO:0060147)2.53363906
149regulation of gene silencing by miRNA (GO:0060964)2.53363906
150regulation of gene silencing by RNA (GO:0060966)2.53363906
151regulation of gene silencing (GO:0060968)2.52985028
152regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.52740282
153negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.52396200
154negative regulation of mRNA metabolic process (GO:1903312)2.52271919
155chromatin remodeling at centromere (GO:0031055)2.51344689
156aromatic amino acid family catabolic process (GO:0009074)2.51116294
157DNA damage response, detection of DNA damage (GO:0042769)2.49703617
158polarized epithelial cell differentiation (GO:0030859)2.46023389
159cell fate commitment involved in formation of primary germ layer (GO:0060795)2.44468751
160DNA topological change (GO:0006265)2.44340629
161negative regulation of RNA splicing (GO:0033119)2.43511300
162positive regulation of chromosome segregation (GO:0051984)2.43495022

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.70946162
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.41003984
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.82724188
4* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.00797679
5MYC_18358816_ChIP-ChIP_MESCs_Mouse2.88676840
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.88035075
7ETS1_20019798_ChIP-Seq_JURKAT_Human2.86295943
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.85516860
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.79281044
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.77759860
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.75466161
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.71963713
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.61039719
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.51853498
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.42862914
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.40052954
17FOXM1_23109430_ChIP-Seq_U2OS_Human2.36540498
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.32400354
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.32296431
20XRN2_22483619_ChIP-Seq_HELA_Human2.21647932
21* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.16573736
22VDR_23849224_ChIP-Seq_CD4+_Human2.10163446
23DCP1A_22483619_ChIP-Seq_HELA_Human2.07383505
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.06770560
25ELF1_17652178_ChIP-ChIP_JURKAT_Human2.05764067
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.95458049
27CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.94197519
28* FOXP3_21729870_ChIP-Seq_TREG_Human1.92031128
29THAP11_20581084_ChIP-Seq_MESCs_Mouse1.88289653
30* GABP_19822575_ChIP-Seq_HepG2_Human1.88163336
31PPARA_22158963_ChIP-Seq_LIVER_Mouse1.87501481
32ZNF263_19887448_ChIP-Seq_K562_Human1.85339015
33MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.78503421
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77390467
35RXR_22158963_ChIP-Seq_LIVER_Mouse1.75819016
36* NOTCH1_21737748_ChIP-Seq_TLL_Human1.75560836
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.74306375
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.74221515
39ESR1_15608294_ChIP-ChIP_MCF-7_Human1.73736593
40AR_21909140_ChIP-Seq_LNCAP_Human1.71785045
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.71760388
42EGR1_23403033_ChIP-Seq_LIVER_Mouse1.69379577
43SALL1_21062744_ChIP-ChIP_HESCs_Human1.69068315
44STAT3_1855785_ChIP-Seq_MESCs_Mouse1.68347881
45ZFX_18555785_ChIP-Seq_MESCs_Mouse1.66409450
46TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.62948249
47MYCN_18555785_ChIP-Seq_MESCs_Mouse1.57883920
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.57773117
49CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.57600200
50SRF_21415370_ChIP-Seq_HL-1_Mouse1.55687112
51CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.53299650
52E2F1_21310950_ChIP-Seq_MCF-7_Human1.53156191
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.51846493
54TTF2_22483619_ChIP-Seq_HELA_Human1.51223435
55MYC_22102868_ChIP-Seq_BL_Human1.49893031
56PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.49192002
57HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.48567660
58TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.48092967
59CIITA_25753668_ChIP-Seq_RAJI_Human1.46480868
60POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.46300150
61MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.44243921
62RBPJ_22232070_ChIP-Seq_NCS_Mouse1.38895229
63YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34517131
64FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.34275771
65* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.34159622
66FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.33202008
67PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.32244037
68ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.29765524
69SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.27375612
70PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.27064695
71HOXB4_20404135_ChIP-ChIP_EML_Mouse1.26588641
72HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.24725985
73* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.22722825
74KDM5A_27292631_Chip-Seq_BREAST_Human1.20359708
75ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17982474
76SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.16806367
77SOX2_16153702_ChIP-ChIP_HESCs_Human1.14312973
78POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.14241939
79FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.13682041
80NANOG_16153702_ChIP-ChIP_HESCs_Human1.13139128
81DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.11797737
82DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.11726318
83TCF3_18692474_ChIP-Seq_MEFs_Mouse1.11453949
84SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.10751479
85SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.08892468
86LXR_22158963_ChIP-Seq_LIVER_Mouse1.07677791
87TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07214853
88CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.06652069
89BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.05115323
90KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.04449487
91CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.03741236
92TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03305880
93SOX2_18555785_ChIP-Seq_MESCs_Mouse1.03005758
94KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.02954172
95CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01534851
96SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.01346250
97CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.99830939
98TFEB_21752829_ChIP-Seq_HELA_Human0.99752780
99CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.99113100
100HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.98682534
101SOX17_20123909_ChIP-Seq_XEN_Mouse0.95748191
102NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.95641435
103SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.95280566
104ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.93880924
105ELK1_19687146_ChIP-ChIP_HELA_Human0.93417441
106ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.93155378
107* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93093450
108NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.93080201
109ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.92648195
110ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.92596677
111CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.92305428
112KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.91857344
113FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.91688616
114TBX5_21415370_ChIP-Seq_HL-1_Mouse0.91433368
115TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.91213906
116IRF1_19129219_ChIP-ChIP_H3396_Human0.90617322
117NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.90320518
118MYC_18940864_ChIP-ChIP_HL60_Human0.89818398
119SRY_22984422_ChIP-ChIP_TESTIS_Rat0.89392874
120ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.88931897
121* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.88599225
122ZNF274_21170338_ChIP-Seq_K562_Hela0.88478669
123PADI4_21655091_ChIP-ChIP_MCF-7_Human0.88327084
124SOX2_18692474_ChIP-Seq_MEFs_Mouse0.88204250
125* FOXP1_21924763_ChIP-Seq_HESCs_Human0.87092381
126TP63_19390658_ChIP-ChIP_HaCaT_Human0.85590841
127* CHD1_26751641_Chip-Seq_LNCaP_Human0.85546425
128OCT4_18692474_ChIP-Seq_MEFs_Mouse0.85158411
129RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.83236770
130CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.83186100
131SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.82784059

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis3.98033997
2MP0002139_abnormal_hepatobiliary_system3.35978680
3MP0009379_abnormal_foot_pigmentation3.33880398
4MP0003693_abnormal_embryo_hatching3.33128131
5MP0005365_abnormal_bile_salt2.95139331
6MP0005085_abnormal_gallbladder_physiolo2.93049935
7MP0005360_urolithiasis2.91264267
8MP0003111_abnormal_nucleus_morphology2.87184580
9MP0010352_gastrointestinal_tract_polyps2.82927832
10MP0004957_abnormal_blastocyst_morpholog2.54058064
11MP0003077_abnormal_cell_cycle2.42370585
12MP0010094_abnormal_chromosome_stability2.31817520
13MP0002396_abnormal_hematopoietic_system2.12005832
14MP0009840_abnormal_foam_cell2.11278248
15MP0008058_abnormal_DNA_repair2.10165369
16MP0004233_abnormal_muscle_weight1.97280579
17MP0001730_embryonic_growth_arrest1.95579838
18MP0008057_abnormal_DNA_replication1.84934744
19MP0003937_abnormal_limbs/digits/tail_de1.77101360
20MP0000537_abnormal_urethra_morphology1.76381043
21MP0003123_paternal_imprinting1.67605825
22MP0000566_synostosis1.65396857
23MP0003303_peritoneal_inflammation1.64636959
24MP0006292_abnormal_olfactory_placode1.61645592
25MP0008007_abnormal_cellular_replicative1.58060216
26MP0006036_abnormal_mitochondrial_physio1.57786052
27MP0010329_abnormal_lipoprotein_level1.51228899
28MP0000490_abnormal_crypts_of1.50470109
29MP0003786_premature_aging1.49350335
30MP0002254_reproductive_system_inflammat1.48675264
31MP0010030_abnormal_orbit_morphology1.43928266
32MP0004147_increased_porphyrin_level1.42415863
33MP0005083_abnormal_biliary_tract1.42253473
34MP0003252_abnormal_bile_duct1.39290881
35MP0008995_early_reproductive_senescence1.36945569
36MP0003119_abnormal_digestive_system1.36137648
37MP0008932_abnormal_embryonic_tissue1.35775966
38MP0000579_abnormal_nail_morphology1.34615653
39MP0003763_abnormal_thymus_physiology1.34558210
40MP0009697_abnormal_copulation1.32631749
41MP0005408_hypopigmentation1.32541793
42MP0004130_abnormal_muscle_cell1.29634192
43MP0002938_white_spotting1.28333720
44MP0003868_abnormal_feces_composition1.28288513
45MP0008875_abnormal_xenobiotic_pharmacok1.27752906
46MP0005670_abnormal_white_adipose1.25874523
47MP0002160_abnormal_reproductive_system1.25105552
48MP0001529_abnormal_vocalization1.23713064
49MP0004197_abnormal_fetal_growth/weight/1.22012234
50MP0005332_abnormal_amino_acid1.21194879
51MP0002138_abnormal_hepatobiliary_system1.20960321
52MP0003186_abnormal_redox_activity1.20489908
53MP0001672_abnormal_embryogenesis/_devel1.19430158
54MP0005380_embryogenesis_phenotype1.19430158
55MP0000350_abnormal_cell_proliferation1.16823755
56MP0003646_muscle_fatigue1.16254294
57MP0005248_abnormal_Harderian_gland1.14905462
58MP0005330_cardiomyopathy1.14654461
59MP0001697_abnormal_embryo_size1.12991326
60MP0000609_abnormal_liver_physiology1.12861216
61MP0009672_abnormal_birth_weight1.12695702
62MP0001346_abnormal_lacrimal_gland1.12340006
63MP0002697_abnormal_eye_size1.12149737
64MP0002080_prenatal_lethality1.11895646
65MP0003718_maternal_effect1.11794505
66MP0005075_abnormal_melanosome_morpholog1.09971608
67MP0002111_abnormal_tail_morphology1.08867765
68MP0005319_abnormal_enzyme/_coenzyme1.07258475
69MP0000647_abnormal_sebaceous_gland1.06396598
70MP0010234_abnormal_vibrissa_follicle1.06077375
71MP0002086_abnormal_extraembryonic_tissu1.05183411
72MP0001293_anophthalmia1.04682819
73MP0001666_abnormal_nutrient_absorption1.04232204
74MP0005220_abnormal_exocrine_pancreas1.04154150
75MP0003984_embryonic_growth_retardation1.04079140
76MP0009703_decreased_birth_body1.03832911
77MP0002088_abnormal_embryonic_growth/wei1.02425159
78MP0001764_abnormal_homeostasis1.00857623
79MP0006035_abnormal_mitochondrial_morpho0.99609272
80MP0002233_abnormal_nose_morphology0.99423294
81MP0004264_abnormal_extraembryonic_tissu0.98692329
82MP0003567_abnormal_fetal_cardiomyocyte0.98488605
83MP0003191_abnormal_cellular_cholesterol0.95206876
84MP0003890_abnormal_embryonic-extraembry0.95202464
85MP0001661_extended_life_span0.95095765
86MP0000049_abnormal_middle_ear0.93612260
87MP0002019_abnormal_tumor_incidence0.93283645
88MP0001873_stomach_inflammation0.93202817
89MP0008877_abnormal_DNA_methylation0.93116666
90MP0000613_abnormal_salivary_gland0.92806651
91MP0004782_abnormal_surfactant_physiolog0.92183962
92MP0004185_abnormal_adipocyte_glucose0.91875315
93MP0001929_abnormal_gametogenesis0.91786396
94MP0003385_abnormal_body_wall0.91593069
95MP0003136_yellow_coat_color0.91397060
96MP0000598_abnormal_liver_morphology0.90572099
97MP0010307_abnormal_tumor_latency0.90428505
98MP0003195_calcinosis0.90115312
99MP0009333_abnormal_splenocyte_physiolog0.89161935
100MP0003861_abnormal_nervous_system0.88847095
101MP0000747_muscle_weakness0.87878526
102MP0000313_abnormal_cell_death0.87619650
103MP0001145_abnormal_male_reproductive0.85268592
104MP0002085_abnormal_embryonic_tissue0.84806497
105MP0002102_abnormal_ear_morphology0.84503239
106MP0000358_abnormal_cell_content/0.84268551
107MP0005187_abnormal_penis_morphology0.83716928
108MP0002118_abnormal_lipid_homeostasis0.83113728
109MP0003755_abnormal_palate_morphology0.82825795
110MP0000371_diluted_coat_color0.82609714
111MP0002098_abnormal_vibrissa_morphology0.81636868
112MP0001243_abnormal_dermal_layer0.80731945
113MP0001299_abnormal_eye_distance/0.78551705
114MP0002084_abnormal_developmental_patter0.77182349
115MP0003942_abnormal_urinary_system0.76861977
116MP0000703_abnormal_thymus_morphology0.76330711
117MP0000462_abnormal_digestive_system0.75903847
118MP0006072_abnormal_retinal_apoptosis0.75638465
119MP0002722_abnormal_immune_system0.74997802
120MP0000428_abnormal_craniofacial_morphol0.74674568
121MP0001286_abnormal_eye_development0.74080860
122MP0002269_muscular_atrophy0.73973774
123MP0003698_abnormal_male_reproductive0.73184072
124MP0001853_heart_inflammation0.72810971
125MP0003656_abnormal_erythrocyte_physiolo0.72426307
126MP0009643_abnormal_urine_homeostasis0.72173667
127MP0000689_abnormal_spleen_morphology0.71908148
128MP0004808_abnormal_hematopoietic_stem0.71517377
129MP0002877_abnormal_melanocyte_morpholog0.71180204
130MP0003935_abnormal_craniofacial_develop0.70720359
131MP0003315_abnormal_perineum_morphology0.70629632
132MP0000653_abnormal_sex_gland0.69955316
133MP0005501_abnormal_skin_physiology0.69374352
134MP0000383_abnormal_hair_follicle0.69258974
135MP0005671_abnormal_response_to0.68936241
136MP0002398_abnormal_bone_marrow0.68553733
137MP0002161_abnormal_fertility/fecundity0.67398758
138MP0003941_abnormal_skin_development0.67112226
139MP0003705_abnormal_hypodermis_morpholog0.66879748
140MP0004133_heterotaxia0.66618377
141MP0002210_abnormal_sex_determination0.66587677
142MP0000477_abnormal_intestine_morphology0.66528433
143MP0001177_atelectasis0.65642337
144MP0003221_abnormal_cardiomyocyte_apopto0.65524130
145MP0009763_increased_sensitivity_to0.64933867
146MP0010678_abnormal_skin_adnexa0.64757978
147MP0001849_ear_inflammation0.64536490
148MP0003115_abnormal_respiratory_system0.64072553

Predicted human phenotypes

RankGene SetZ-score
1Colon cancer (HP:0003003)5.21822651
2Reticulocytopenia (HP:0001896)3.99786046
3Abnormality of aromatic amino acid family metabolism (HP:0004338)3.94497640
4Chromosomal breakage induced by crosslinking agents (HP:0003221)3.82746742
5Abnormality of monocarboxylic acid metabolism (HP:0010996)3.75617137
6Cerebellar dysplasia (HP:0007033)3.69279570
7Retinal atrophy (HP:0001105)3.68125408
8Abnormality of pyrimidine metabolism (HP:0004353)3.57655771
9Microretrognathia (HP:0000308)3.56166848
10Chromsome breakage (HP:0040012)3.53653810
11Hyperglycinemia (HP:0002154)3.47619863
12Hypobetalipoproteinemia (HP:0003563)3.36268207
13Intrahepatic cholestasis (HP:0001406)3.25949229
14Epidermoid cyst (HP:0200040)3.25276087
15Birth length less than 3rd percentile (HP:0003561)3.13604388
16Hyperammonemia (HP:0001987)2.97605496
17Hyperglycinuria (HP:0003108)2.97441311
18Hypoglycemic coma (HP:0001325)2.96358912
19Ependymoma (HP:0002888)2.90488071
20Multiple enchondromatosis (HP:0005701)2.89840976
21* Ragged-red muscle fibers (HP:0003200)2.87208681
22Progressive muscle weakness (HP:0003323)2.85920347
23Abnormality of serine family amino acid metabolism (HP:0010894)2.84528098
24Abnormality of glycine metabolism (HP:0010895)2.84528098
25Anterior segment dysgenesis (HP:0007700)2.74468529
26Microvesicular hepatic steatosis (HP:0001414)2.63187736
27Carpal bone hypoplasia (HP:0001498)2.59496661
28Abnormality of cells of the erythroid lineage (HP:0012130)2.57742662
29Meckel diverticulum (HP:0002245)2.56253017
30Macrocytic anemia (HP:0001972)2.54836594
31Medulloblastoma (HP:0002885)2.53925354
32Difficulty climbing stairs (HP:0003551)2.53583127
33Abnormality of serum amino acid levels (HP:0003112)2.49533752
34Abnormality of the ileum (HP:0001549)2.44813205
35Abnormal number of erythroid precursors (HP:0012131)2.43387536
36Hepatic necrosis (HP:0002605)2.42424534
37Oral leukoplakia (HP:0002745)2.37366460
38Breast hypoplasia (HP:0003187)2.33379921
39Abnormality of alanine metabolism (HP:0010916)2.31093355
40Hyperalaninemia (HP:0003348)2.31093355
41Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.31093355
42Dicarboxylic aciduria (HP:0003215)2.29959281
43Abnormality of dicarboxylic acid metabolism (HP:0010995)2.29959281
44IgM deficiency (HP:0002850)2.28256880
45Nephroblastoma (Wilms tumor) (HP:0002667)2.27792217
46Absent thumb (HP:0009777)2.27720066
47Increased nuchal translucency (HP:0010880)2.26890778
48Xanthomatosis (HP:0000991)2.26757731
49Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.25565607
50Hepatocellular carcinoma (HP:0001402)2.25017084
51Prolonged partial thromboplastin time (HP:0003645)2.24881035
52Neoplasm of the small intestine (HP:0100833)2.22060845
53Spastic diplegia (HP:0001264)2.22008166
54Selective tooth agenesis (HP:0001592)2.19672973
55Aplastic anemia (HP:0001915)2.19221856
56Cortical dysplasia (HP:0002539)2.18957087
57Rhabdomyolysis (HP:0003201)2.18523698
58Neoplasm of the adrenal gland (HP:0100631)2.17055469
59Pancytopenia (HP:0001876)2.16935214
60Thrombocytosis (HP:0001894)2.16410810
61Late onset (HP:0003584)2.15416651
62Ketosis (HP:0001946)2.14349252
63Aplasia/Hypoplasia of the sacrum (HP:0008517)2.13324779
64Delayed CNS myelination (HP:0002188)2.12433946
65* Increased serum lactate (HP:0002151)2.12428082
66Type II lissencephaly (HP:0007260)2.12228198
67Neoplasm of the adrenal cortex (HP:0100641)2.12168704
68Hypolipoproteinemia (HP:0010981)2.10834453
69Embryonal renal neoplasm (HP:0011794)2.10023052
70Abnormal lung lobation (HP:0002101)2.09936130
71Abnormal biliary tract morphology (HP:0012440)2.08745928
72Neoplasm of the colon (HP:0100273)2.08216073
73Hypoplasia of the capital femoral epiphysis (HP:0003090)2.06502764
74Hepatoblastoma (HP:0002884)2.05958238
75Abnormality of fatty-acid metabolism (HP:0004359)2.05536004
76Septate vagina (HP:0001153)2.05342673
77* Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.03682483
78* Decreased activity of mitochondrial respiratory chain (HP:0008972)2.03682483
79Lethargy (HP:0001254)2.02449272
80Biliary tract neoplasm (HP:0100574)2.02378650
81Pallor (HP:0000980)2.00039349
82Abnormality of glycolysis (HP:0004366)1.98837667
83Increased serum pyruvate (HP:0003542)1.98837667
84Hepatocellular necrosis (HP:0001404)1.97783345
85Astrocytoma (HP:0009592)1.97328052
86Abnormality of the astrocytes (HP:0100707)1.97328052
87Abnormality of nucleobase metabolism (HP:0010932)1.95703949
88Abnormality of the preputium (HP:0100587)1.95268721
89Neoplasm of the oral cavity (HP:0100649)1.95140312
90Easy fatigability (HP:0003388)1.95058572
91Aplasia/Hypoplasia of the uvula (HP:0010293)1.94779987
9211 pairs of ribs (HP:0000878)1.94682695
93Abnormality of the carotid arteries (HP:0005344)1.94239693
94Absent radius (HP:0003974)1.94219943
95Abnormality of methionine metabolism (HP:0010901)1.94186051
96Hyperlipoproteinemia (HP:0010980)1.93918373
97Tented upper lip vermilion (HP:0010804)1.93859777
98Bilateral microphthalmos (HP:0007633)1.93537131
99Spinal rigidity (HP:0003306)1.93103442
100Deep venous thrombosis (HP:0002625)1.92383832
101Abnormal cartilage morphology (HP:0002763)1.90110892
102Nausea (HP:0002018)1.88752821
103Absent forearm bone (HP:0003953)1.87276514
104Aplasia involving forearm bones (HP:0009822)1.87276514
105Cerebral edema (HP:0002181)1.87168828
106High anterior hairline (HP:0009890)1.86893665
107Abnormality of the anterior horn cell (HP:0006802)1.86313892
108Degeneration of anterior horn cells (HP:0002398)1.86313892
109Glioma (HP:0009733)1.84649116
110Duodenal stenosis (HP:0100867)1.84401553
111Small intestinal stenosis (HP:0012848)1.84401553
112Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.83782930
113Abnormal protein N-linked glycosylation (HP:0012347)1.83782930
114Abnormal protein glycosylation (HP:0012346)1.83782930
115Abnormal glycosylation (HP:0012345)1.83782930
116Facial cleft (HP:0002006)1.81926440
117Type 1 muscle fiber predominance (HP:0003803)1.80447972
118Cellular immunodeficiency (HP:0005374)1.80082130
119Abnormal hemoglobin (HP:0011902)1.79493430
120Retinal dysplasia (HP:0007973)1.78969160
121Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.78841145
122Overriding aorta (HP:0002623)1.78565115
123Horseshoe kidney (HP:0000085)1.78049801
124Abnormality of sulfur amino acid metabolism (HP:0004339)1.77333128
125Abnormality of the labia minora (HP:0012880)1.77285723
126Skull defect (HP:0001362)1.76296079
127Abnormality of aspartate family amino acid metabolism (HP:0010899)1.75561469
128Renal cortical cysts (HP:0000803)1.74613970
129Type I transferrin isoform profile (HP:0003642)1.73931040
130Anal atresia (HP:0002023)1.73605246
131Progressive external ophthalmoplegia (HP:0000590)1.73344599
132CNS hypomyelination (HP:0003429)1.73019393
133Abnormality of chromosome stability (HP:0003220)1.72906294
134Abnormality of cochlea (HP:0000375)1.72822643
135Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.72760984
136Vaginal fistula (HP:0004320)1.70784602
137Shoulder girdle muscle weakness (HP:0003547)1.70534197
138Sloping forehead (HP:0000340)1.66757084
139Brittle hair (HP:0002299)1.65837023
140Patellar aplasia (HP:0006443)1.65571157
141Cerebral hypomyelination (HP:0006808)1.64614807
142Exercise-induced muscle cramps (HP:0003710)1.61205354
143Rhabdomyosarcoma (HP:0002859)1.60720394
144Acute encephalopathy (HP:0006846)1.59975301
145Lipid accumulation in hepatocytes (HP:0006561)1.58070753
146Postnatal microcephaly (HP:0005484)1.57174962
147Hypoplastic pelvis (HP:0008839)1.57173378
148Abnormality of the duodenum (HP:0002246)1.56541203
149Abnormality of homocysteine metabolism (HP:0010919)1.56505350
150Homocystinuria (HP:0002156)1.56505350
151Breast carcinoma (HP:0003002)1.55447141
152Pancreatic islet-cell hyperplasia (HP:0004510)1.55195524
153Squamous cell carcinoma (HP:0002860)1.54412025
154Embryonal neoplasm (HP:0002898)1.53910507
155Clitoromegaly (HP:0000057)1.53634251
156Choanal atresia (HP:0000453)1.53016773
157Duplication of thumb phalanx (HP:0009942)1.52154290
158Hyperacusis (HP:0010780)1.51652743
159Abnormality of DNA repair (HP:0003254)1.51157674
160Aplasia/Hypoplasia of the sternum (HP:0006714)1.50659726
161Aplasia/Hypoplasia of the patella (HP:0006498)1.49796881
162* Lactic acidosis (HP:0003128)1.48973384
163Proximal placement of thumb (HP:0009623)1.48332928
164Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.48190571
165Absent epiphyses (HP:0010577)1.48190571
166Deviation of the thumb (HP:0009603)1.47947403
167Choanal stenosis (HP:0000452)1.47264402

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SRPK14.86763923
2EIF2AK14.05143842
3BUB13.47762567
4BCKDK3.20794223
5VRK23.15517486
6SMG13.10594179
7WEE12.67877168
8TAF12.56469901
9MAP4K12.49244484
10TESK22.49050541
11NME22.44817099
12CDC72.43949260
13TLK12.15677367
14EPHA22.06746251
15PASK1.95888315
16FLT31.95345951
17PBK1.77278001
18EIF2AK31.74605879
19KDR1.71587340
20NME11.67572881
21PKN21.65821568
22NEK21.58700741
23PNCK1.56962180
24CSNK1G31.55247678
25TTK1.52019940
26ZAP701.47107960
27MAP3K111.45246284
28RPS6KA41.44622739
29CSNK1A1L1.44238020
30PDK21.42753195
31WNK41.40810237
32CSNK1G11.39737167
33CDK71.37984907
34NEK11.36710637
35BRSK21.35684316
36MAP3K101.34499274
37MKNK11.34448092
38DYRK31.30557813
39ATR1.29896936
40MKNK21.29039765
41CDK121.27604917
42RPS6KB21.26889012
43AURKB1.25681521
44PLK11.25349827
45SCYL21.24592592
46MET1.23452169
47PLK41.22672812
48STK161.17540288
49CDK41.17457175
50STK38L1.14563534
51NUAK11.11905564
52ACVR1B1.10434777
53ZAK1.08651694
54EIF2AK21.06972636
55TSSK61.06562678
56PHKG21.02671645
57PHKG11.02671645
58MAP3K80.98529544
59CDK80.96708303
60AURKA0.94897449
61MAP2K30.93449918
62MUSK0.91103018
63FGFR40.89901739
64CHEK20.89616117
65VRK10.88692838
66MAPKAPK50.88634157
67ICK0.85904206
68CSNK1G20.84454609
69DAPK10.82210060
70PIM10.81613388
71STK100.78918245
72EEF2K0.77650995
73TESK10.74366013
74CHEK10.73993549
75CDK10.72104818
76MAPK110.71551414
77CSNK2A20.71379531
78MAP2K60.68217553
79WNK30.67805811
80PRKCI0.67674323
81DYRK20.67137552
82MST1R0.67015644
83CSNK2A10.66126050
84BMPR1B0.65184716
85LATS10.65104608
86BRSK10.64121750
87LATS20.63441393
88STK40.63005728
89PDK40.61485411
90PDK30.61485411
91MYLK0.60163057
92CAMK1D0.58118330
93IRAK30.57421175
94GRK60.57158722
95ATM0.56661586
96MAPKAPK30.55928304
97STK390.53895658
98TEC0.53803174
99TRIB30.53115855
100STK30.52841472
101NTRK10.52455992
102TXK0.52389578
103FGFR20.52120995
104LRRK20.50357297
105CDK190.49103713
106PRKDC0.48975808
107CDK20.48654113
108KSR20.48392532
109FGFR10.48170313
110BTK0.46667317
111SIK10.46579158
112TGFBR10.46471319
113PRKAA10.44923732
114PRKD30.44868937
115ALK0.44078138
116MTOR0.43579574
117RPS6KA50.43348656
118CDK90.42844727
119ERN10.42838811
120CAMK1G0.42103396
121TYK20.41044726
122FER0.40869637
123PIM20.40352466
124PAK40.39767221
125MAP3K90.38499911
126RPS6KB10.37851440
127ERBB40.37679803
128AKT20.36741100
129PLK30.36293332
130CSNK1D0.34010082
131BRD40.31065346
132MARK30.30964963
133BRAF0.30008859
134IKBKE0.29555662
135PAK10.28864813
136CSNK1E0.28572556
137ITK0.27683745
138IKBKB0.26609872
139MAP2K20.25743715

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.27207852
2DNA replication_Homo sapiens_hsa030302.98992917
3Selenocompound metabolism_Homo sapiens_hsa004502.77366641
4Mismatch repair_Homo sapiens_hsa034302.54420528
5RNA polymerase_Homo sapiens_hsa030202.49996116
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.44075621
7One carbon pool by folate_Homo sapiens_hsa006702.40298540
8Proteasome_Homo sapiens_hsa030502.34660109
9Drug metabolism - other enzymes_Homo sapiens_hsa009832.20594791
10Folate biosynthesis_Homo sapiens_hsa007902.15766093
11Spliceosome_Homo sapiens_hsa030402.10279577
12* Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.09085564
13Pyrimidine metabolism_Homo sapiens_hsa002402.03137309
14Homologous recombination_Homo sapiens_hsa034402.00055138
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.96678573
16Base excision repair_Homo sapiens_hsa034101.92235232
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.91827519
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.91737689
19RNA transport_Homo sapiens_hsa030131.88234107
20Sulfur metabolism_Homo sapiens_hsa009201.87834948
21Primary bile acid biosynthesis_Homo sapiens_hsa001201.83050568
22Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.74271274
23Cysteine and methionine metabolism_Homo sapiens_hsa002701.73194677
24Biosynthesis of amino acids_Homo sapiens_hsa012301.67137694
25Fatty acid degradation_Homo sapiens_hsa000711.58731918
26Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.55996561
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.55900214
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.54699666
29Steroid biosynthesis_Homo sapiens_hsa001001.51769133
30Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.51652156
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.50690316
32Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.46983421
33Tryptophan metabolism_Homo sapiens_hsa003801.44647352
34Nucleotide excision repair_Homo sapiens_hsa034201.41851965
35Caffeine metabolism_Homo sapiens_hsa002321.38458374
36Carbon metabolism_Homo sapiens_hsa012001.36372049
37Sulfur relay system_Homo sapiens_hsa041221.33084986
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.30172163
39Fatty acid elongation_Homo sapiens_hsa000621.26135499
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.24907895
41Cell cycle_Homo sapiens_hsa041101.23900855
42Pentose phosphate pathway_Homo sapiens_hsa000301.23798637
43Arginine biosynthesis_Homo sapiens_hsa002201.23303668
44Cyanoamino acid metabolism_Homo sapiens_hsa004601.21449310
45Nitrogen metabolism_Homo sapiens_hsa009101.19787263
46Propanoate metabolism_Homo sapiens_hsa006401.11890144
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.08614507
48Peroxisome_Homo sapiens_hsa041461.03557601
49Purine metabolism_Homo sapiens_hsa002301.03128362
50* Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.00904319
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.00579153
52RNA degradation_Homo sapiens_hsa030180.99783910
53Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.99234240
54Fanconi anemia pathway_Homo sapiens_hsa034600.97416874
55Pyruvate metabolism_Homo sapiens_hsa006200.96370603
56Protein export_Homo sapiens_hsa030600.92988962
57Glutathione metabolism_Homo sapiens_hsa004800.90050046
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.87719355
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.85827211
60beta-Alanine metabolism_Homo sapiens_hsa004100.85199116
61Vitamin B6 metabolism_Homo sapiens_hsa007500.84107212
62Complement and coagulation cascades_Homo sapiens_hsa046100.81742736
63Fatty acid metabolism_Homo sapiens_hsa012120.80834280
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.80085662
65Central carbon metabolism in cancer_Homo sapiens_hsa052300.79611758
66Non-homologous end-joining_Homo sapiens_hsa034500.79103444
67Vitamin digestion and absorption_Homo sapiens_hsa049770.78723737
68Arginine and proline metabolism_Homo sapiens_hsa003300.78197367
69Fatty acid biosynthesis_Homo sapiens_hsa000610.76078714
70Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74183854
71Basal transcription factors_Homo sapiens_hsa030220.73899449
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71434341
73Fat digestion and absorption_Homo sapiens_hsa049750.67793266
74Butanoate metabolism_Homo sapiens_hsa006500.67565543
75Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.67115277
76Fructose and mannose metabolism_Homo sapiens_hsa000510.66273107
77Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.66244920
78PPAR signaling pathway_Homo sapiens_hsa033200.66209746
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64031303
80Chemical carcinogenesis_Homo sapiens_hsa052040.63520530
81* Metabolic pathways_Homo sapiens_hsa011000.62388403
82Oocyte meiosis_Homo sapiens_hsa041140.61368333
83Retinol metabolism_Homo sapiens_hsa008300.59843651
84Hippo signaling pathway_Homo sapiens_hsa043900.59268210
85Galactose metabolism_Homo sapiens_hsa000520.57480910
86Lysine degradation_Homo sapiens_hsa003100.56966513
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56861165
88p53 signaling pathway_Homo sapiens_hsa041150.56165651
89Primary immunodeficiency_Homo sapiens_hsa053400.55933816
90Histidine metabolism_Homo sapiens_hsa003400.54835300
91mRNA surveillance pathway_Homo sapiens_hsa030150.52468559
92Phenylalanine metabolism_Homo sapiens_hsa003600.51995750
93Herpes simplex infection_Homo sapiens_hsa051680.50951093
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48558395
95Systemic lupus erythematosus_Homo sapiens_hsa053220.47393459
96Basal cell carcinoma_Homo sapiens_hsa052170.43155991
97Starch and sucrose metabolism_Homo sapiens_hsa005000.40316189
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40091681
99Tyrosine metabolism_Homo sapiens_hsa003500.39997583
100Alcoholism_Homo sapiens_hsa050340.38067546
101ABC transporters_Homo sapiens_hsa020100.37265831
102Huntingtons disease_Homo sapiens_hsa050160.36191883
103Epstein-Barr virus infection_Homo sapiens_hsa051690.35740711
104Oxidative phosphorylation_Homo sapiens_hsa001900.34207906
105Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.34166406
106Thyroid cancer_Homo sapiens_hsa052160.34028902
107Steroid hormone biosynthesis_Homo sapiens_hsa001400.33553348
108Parkinsons disease_Homo sapiens_hsa050120.33325095
109Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32911328
110Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30527596
111Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.29708634
112N-Glycan biosynthesis_Homo sapiens_hsa005100.29564603
113AMPK signaling pathway_Homo sapiens_hsa041520.27897613
114Staphylococcus aureus infection_Homo sapiens_hsa051500.27646957
115Bladder cancer_Homo sapiens_hsa052190.27499006
116Tight junction_Homo sapiens_hsa045300.26678640
117Glucagon signaling pathway_Homo sapiens_hsa049220.26405492
118MicroRNAs in cancer_Homo sapiens_hsa052060.26031083
119Antigen processing and presentation_Homo sapiens_hsa046120.24904667
120RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.24663499
121Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.23687666
122Viral carcinogenesis_Homo sapiens_hsa052030.23146777
123TGF-beta signaling pathway_Homo sapiens_hsa043500.20496566
124Melanoma_Homo sapiens_hsa052180.19402654
125Phototransduction_Homo sapiens_hsa047440.16804179
126Wnt signaling pathway_Homo sapiens_hsa043100.15258166
127Vibrio cholerae infection_Homo sapiens_hsa051100.11023057

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »