EBAG9P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1granulocyte differentiation (GO:0030851)9.57700439
2response to misfolded protein (GO:0051788)8.47606027
3macrophage differentiation (GO:0030225)8.39945637
4positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)7.87316472
5response to nitrosative stress (GO:0051409)7.64580864
6estrogen biosynthetic process (GO:0006703)7.49078806
7histone H2B ubiquitination (GO:0033523)7.44620298
8negative regulation of calcium ion-dependent exocytosis (GO:0045955)7.35758285
9cell fate commitment involved in formation of primary germ layer (GO:0060795)7.00363978
10regulation of autophagic vacuole assembly (GO:2000785)6.94232393
11negative regulation of leukocyte migration (GO:0002686)6.79884604
12xenobiotic catabolic process (GO:0042178)6.67697932
13negative regulation of NF-kappaB import into nucleus (GO:0042347)6.31935312
14misfolded or incompletely synthesized protein catabolic process (GO:0006515)6.25413896
15protein destabilization (GO:0031648)5.97304151
16cerebellar granule cell differentiation (GO:0021707)5.92006781
17serotonin metabolic process (GO:0042428)5.79691345
18regulation of vacuole organization (GO:0044088)5.79354685
19negative regulation of mast cell activation (GO:0033004)5.66122664
20negative regulation of chemotaxis (GO:0050922)5.40021370
21ribonucleoprotein complex disassembly (GO:0032988)5.36456981
22positive regulation of mRNA 3-end processing (GO:0031442)5.20783445
23cytoplasmic sequestering of transcription factor (GO:0042994)5.20227167
24phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)5.06248939
25phosphatidylglycerol biosynthetic process (GO:0006655)5.01056912
26CDP-diacylglycerol biosynthetic process (GO:0016024)4.95474372
27primary amino compound metabolic process (GO:1901160)4.77232032
28early endosome to late endosome transport (GO:0045022)4.70303975
29cardiolipin metabolic process (GO:0032048)4.56652254
30protein polyglutamylation (GO:0018095)4.50694306
31cerebral cortex radially oriented cell migration (GO:0021799)4.44738229
32regulation of mRNA 3-end processing (GO:0031440)4.41489330
33cell migration in hindbrain (GO:0021535)4.40583339
34CDP-diacylglycerol metabolic process (GO:0046341)4.33117261
35regulation of hexokinase activity (GO:1903299)4.27563592
36regulation of glucokinase activity (GO:0033131)4.27563592
37cytoplasmic sequestering of protein (GO:0051220)4.11107857
38positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)4.02274025
39autophagic vacuole assembly (GO:0000045)3.91260418
40sodium-independent organic anion transport (GO:0043252)3.84550819
41estrogen metabolic process (GO:0008210)3.81483195
42auditory behavior (GO:0031223)3.78287683
43negative regulation of behavior (GO:0048521)3.73881448
44negative regulation of establishment of protein localization to plasma membrane (GO:0090005)3.73367704
45histone H2A acetylation (GO:0043968)3.67348694
46negative regulation of exocytosis (GO:0045920)3.66170341
47organelle disassembly (GO:1903008)3.65092614
48positive regulation of mRNA processing (GO:0050685)3.60039257
49cellular protein catabolic process (GO:0044257)3.59988127
50negative regulation of autophagy (GO:0010507)3.59488195
51regulation of macroautophagy (GO:0016241)3.51549702
52cytidine metabolic process (GO:0046087)3.49063190
53cytidine catabolic process (GO:0006216)3.49063190
54cytidine deamination (GO:0009972)3.49063190
55negative regulation of fibroblast proliferation (GO:0048147)3.47711824
56regulation of non-canonical Wnt signaling pathway (GO:2000050)3.43167498
57mitotic G1 DNA damage checkpoint (GO:0031571)3.41057263
58mechanosensory behavior (GO:0007638)3.38629915
59adaptation of signaling pathway (GO:0023058)3.34765664
60auditory receptor cell stereocilium organization (GO:0060088)3.17610069
61G1 DNA damage checkpoint (GO:0044783)3.17121284
62ear development (GO:0043583)3.15362008
63benzene-containing compound metabolic process (GO:0042537)3.14254762
64cardiac muscle cell differentiation (GO:0055007)3.13840048
65regulation of vesicle fusion (GO:0031338)3.12296083
66mitotic G1/S transition checkpoint (GO:0044819)3.10531506
67sulfation (GO:0051923)3.04110205
68positive regulation of mitochondrial membrane permeability (GO:0035794)3.03040873
69synaptic vesicle exocytosis (GO:0016079)3.02433100
70lung epithelium development (GO:0060428)3.01568226
71pyrimidine ribonucleoside catabolic process (GO:0046133)2.98816280
72prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.96033541
73G-protein coupled receptor internalization (GO:0002031)2.93461818
74regulation of lipoprotein particle clearance (GO:0010984)2.93100849
75monoubiquitinated protein deubiquitination (GO:0035520)2.92423437
76positive regulation of mRNA metabolic process (GO:1903313)2.90018385
77negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.89459768
78phosphatidylinositol phosphorylation (GO:0046854)2.89168381
79radial glial cell differentiation (GO:0060019)2.88778659
80androgen metabolic process (GO:0008209)2.84260178
81histone monoubiquitination (GO:0010390)2.82021896
82N-terminal protein amino acid acetylation (GO:0006474)2.78077539
83positive regulation of neuroblast proliferation (GO:0002052)2.73632688
84regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902041)2.68055516
85mRNA polyadenylation (GO:0006378)2.66604951
86regulation of calcium ion-dependent exocytosis (GO:0017158)2.65943489
87retinal ganglion cell axon guidance (GO:0031290)2.65150805
88lipid phosphorylation (GO:0046834)2.63215430
89regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.62003643
90tongue development (GO:0043586)2.60492859
91superoxide anion generation (GO:0042554)2.59882816
92sensory perception of pain (GO:0019233)2.59411557
93urate metabolic process (GO:0046415)2.58516256
94response to auditory stimulus (GO:0010996)2.54883516
95retina layer formation (GO:0010842)2.52539025
96cell proliferation in forebrain (GO:0021846)2.52093747
97norepinephrine metabolic process (GO:0042415)2.49938432
98negative regulation of leukocyte chemotaxis (GO:0002689)17.6438074
99regulation of macrophage chemotaxis (GO:0010758)13.4910810
100erythrocyte maturation (GO:0043249)10.7605227

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SRY_22984422_ChIP-ChIP_TESTIS_Rat6.28118295
2GBX2_23144817_ChIP-Seq_PC3_Human5.44081209
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.37337784
4EZH2_27304074_Chip-Seq_ESCs_Mouse3.05014020
5IRF1_19129219_ChIP-ChIP_H3396_Human3.00115516
6TP53_16413492_ChIP-PET_HCT116_Human2.69777194
7E2F7_22180533_ChIP-Seq_HELA_Human2.68302336
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.46388467
9CBX2_27304074_Chip-Seq_ESCs_Mouse2.38618697
10TP63_19390658_ChIP-ChIP_HaCaT_Human2.31107327
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.28255239
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.28255239
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.18293150
14IGF1R_20145208_ChIP-Seq_DFB_Human2.16746699
15AR_25329375_ChIP-Seq_VCAP_Human2.11911660
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.10974631
17POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.01419558
18TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.01419558
19SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.00474226
20IKZF1_21737484_ChIP-ChIP_HCT116_Human1.94013111
21CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.87097289
22SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.86040489
23SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.85658774
24EZH2_27294783_Chip-Seq_ESCs_Mouse1.78897020
25NR3C1_21868756_ChIP-Seq_MCF10A_Human1.78489938
26POU5F1_16153702_ChIP-ChIP_HESCs_Human1.75875777
27JARID2_20075857_ChIP-Seq_MESCs_Mouse1.75500054
28RNF2_27304074_Chip-Seq_ESCs_Mouse1.74725420
29EZH2_22144423_ChIP-Seq_EOC_Human1.72688014
30ESR1_15608294_ChIP-ChIP_MCF-7_Human1.70863202
31PIAS1_25552417_ChIP-Seq_VCAP_Human1.65173339
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60179178
33FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.60104926
34PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.57924767
35BMI1_23680149_ChIP-Seq_NPCS_Mouse1.55594430
36SMAD4_21799915_ChIP-Seq_A2780_Human1.55504544
37NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.52553646
38MTF2_20144788_ChIP-Seq_MESCs_Mouse1.46624119
39SMAD4_21741376_ChIP-Seq_EPCs_Human1.46383564
40TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.46105394
41MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.43049663
42KLF5_20875108_ChIP-Seq_MESCs_Mouse1.42883283
43SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.41627269
44P53_22127205_ChIP-Seq_FIBROBLAST_Human1.40092419
45SUZ12_27294783_Chip-Seq_ESCs_Mouse1.38395269
46CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.35538282
47POU5F1_16518401_ChIP-PET_MESCs_Mouse1.35208396
48ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.35133100
49SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.34862813
50RING1B_27294783_Chip-Seq_NPCs_Mouse1.34072401
51STAT3_18555785_ChIP-Seq_MESCs_Mouse1.32621246
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.29090627
53JUN_21703547_ChIP-Seq_K562_Human1.28395858
54EP300_21415370_ChIP-Seq_HL-1_Mouse1.27924357
55SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.26709450
56EED_16625203_ChIP-ChIP_MESCs_Mouse1.26621521
57DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.24608769
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.24544563
59RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24172896
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.23905307
61FUS_26573619_Chip-Seq_HEK293_Human1.21072238
62REST_21632747_ChIP-Seq_MESCs_Mouse1.18825688
63ARNT_22903824_ChIP-Seq_MCF-7_Human1.18694599
64ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.18615268
65TP53_20018659_ChIP-ChIP_R1E_Mouse1.18122355
66RNF2_27304074_Chip-Seq_NSC_Mouse1.17698790
67CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17454770
68MYC_19829295_ChIP-Seq_ESCs_Human1.16997852
69FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.15297527
70SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.14451822
71ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.13913281
72SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.13586269
73ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.12984488
74MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.12648132
75RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.12236474
76EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.11915339
77TCF4_23295773_ChIP-Seq_U87_Human1.11572501
78UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11405841
79TP53_22573176_ChIP-Seq_HFKS_Human1.10975595
80VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.10948746
81KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.10423086
82MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.10164634
83SMRT_27268052_Chip-Seq_Bcells_Human1.08694503
84HOXB7_26014856_ChIP-Seq_BT474_Human1.08462066
85TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06037310
86OCT4_21477851_ChIP-Seq_ESCs_Mouse1.05727312
87NOTCH1_21737748_ChIP-Seq_TLL_Human1.05480207
88OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05110376
89LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04460215
90FLI1_21867929_ChIP-Seq_TH2_Mouse1.04366207
91P300_19829295_ChIP-Seq_ESCs_Human1.03681431
92STAT1_20625510_ChIP-Seq_HELA_Human1.03428356
93TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02542236
94ER_23166858_ChIP-Seq_MCF-7_Human1.02114552
95GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00643303
96EZH2_27294783_Chip-Seq_NPCs_Mouse0.99894662
97SMAD3_21741376_ChIP-Seq_HESCs_Human0.97387229
98OCT1_27270436_Chip-Seq_PROSTATE_Human0.95654616
99RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.93699080
100ERG_21242973_ChIP-ChIP_JURKAT_Human0.92493444

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004742_abnormal_vestibular_system6.29217487
2MP0000383_abnormal_hair_follicle5.96605288
3MP0005379_endocrine/exocrine_gland_phen4.32974533
4MP0010678_abnormal_skin_adnexa4.19776840
5MP0006292_abnormal_olfactory_placode4.01383677
6MP0003122_maternal_imprinting3.99403837
7MP0000566_synostosis3.34256965
8MP0000427_abnormal_hair_cycle3.30555443
9MP0003011_delayed_dark_adaptation3.12152866
10MP0000647_abnormal_sebaceous_gland2.74918531
11MP0001727_abnormal_embryo_implantation2.67912205
12MP0009053_abnormal_anal_canal2.66849054
13MP0000462_abnormal_digestive_system2.66423683
14MP0009278_abnormal_bone_marrow2.63060312
15MP0002098_abnormal_vibrissa_morphology2.50795035
16MP0005377_hearing/vestibular/ear_phenot2.45198275
17MP0003878_abnormal_ear_physiology2.45198275
18MP0003879_abnormal_hair_cell2.36089342
19MP0010368_abnormal_lymphatic_system2.24195324
20MP0008875_abnormal_xenobiotic_pharmacok2.23826948
21MP0004510_myositis2.22494539
22MP0003121_genomic_imprinting2.16133586
23MP0008789_abnormal_olfactory_epithelium2.06478281
24MP0004885_abnormal_endolymph1.93116334
25MP0000613_abnormal_salivary_gland1.84577066
26MP0005499_abnormal_olfactory_system1.82671294
27MP0005394_taste/olfaction_phenotype1.82671294
28MP0005551_abnormal_eye_electrophysiolog1.78401977
29MP0000750_abnormal_muscle_regeneration1.76826145
30MP0001485_abnormal_pinna_reflex1.72321032
31MP0002282_abnormal_trachea_morphology1.67716450
32MP0000579_abnormal_nail_morphology1.59821918
33MP0005310_abnormal_salivary_gland1.47445550
34MP0001851_eye_inflammation1.39746249
35MP0002102_abnormal_ear_morphology1.39390933
36MP0008872_abnormal_physiological_respon1.31553772
37MP0000026_abnormal_inner_ear1.25497044
38MP0010030_abnormal_orbit_morphology1.22558973
39MP0001270_distended_abdomen1.20572388
40MP0002938_white_spotting1.17257415
41MP0005248_abnormal_Harderian_gland1.14317572
42MP0003705_abnormal_hypodermis_morpholog1.09590512
43MP0000428_abnormal_craniofacial_morphol1.09018173
44MP0001188_hyperpigmentation1.08553751
45MP0004808_abnormal_hematopoietic_stem1.04546617
46MP0000537_abnormal_urethra_morphology1.03652333
47MP0004947_skin_inflammation1.00322943
48MP0004270_analgesia1.00046792
49MP0005187_abnormal_penis_morphology0.98698111
50MP0000377_abnormal_hair_follicle0.88435452
51MP0001958_emphysema0.88022813
52MP0001216_abnormal_epidermal_layer0.87294459
53MP0003315_abnormal_perineum_morphology0.86746369
54MP0002272_abnormal_nervous_system0.82724568
55MP0002796_impaired_skin_barrier0.82139719
56MP0010771_integument_phenotype0.80419602
57MP0002184_abnormal_innervation0.79351582
58MP0001963_abnormal_hearing_physiology0.79032503
59MP0000470_abnormal_stomach_morphology0.78752411
60MP0002970_abnormal_white_adipose0.78374084
61MP0009697_abnormal_copulation0.76174326
62MP0001440_abnormal_grooming_behavior0.75925561
63MP0002822_catalepsy0.75716178
64MP0000778_abnormal_nervous_system0.73531529
65MP0001324_abnormal_eye_pigmentation0.70587187
66MP0006054_spinal_hemorrhage0.69373406
67MP0005595_abnormal_vascular_smooth0.68888305
68MP0001853_heart_inflammation0.68693796
69MP0002106_abnormal_muscle_physiology0.68263838
70MP0001286_abnormal_eye_development0.66640552
71MP0001243_abnormal_dermal_layer0.65565763
72MP0009384_cardiac_valve_regurgitation0.64847814
73MP0005195_abnormal_posterior_eye0.64324561
74MP0005076_abnormal_cell_differentiation0.63069305
75MP0002249_abnormal_larynx_morphology0.62207633
76MP0009115_abnormal_fat_cell0.59277009
77MP0009931_abnormal_skin_appearance0.58757434
78MP0002638_abnormal_pupillary_reflex0.57445494
79MP0005501_abnormal_skin_physiology0.56433049
80MP0005391_vision/eye_phenotype0.56284560
81MP0002233_abnormal_nose_morphology0.56142184
82MP0001915_intracranial_hemorrhage0.53665730
83MP0006138_congestive_heart_failure0.53598223
84MP0001299_abnormal_eye_distance/0.51845854
85MP0005369_muscle_phenotype0.49250993
86MP0002751_abnormal_autonomic_nervous0.49017425
87MP0005381_digestive/alimentary_phenotyp0.48439562
88MP0001879_abnormal_lymphatic_vessel0.48073507
89MP0001765_abnormal_ion_homeostasis0.47305805
90MP0009379_abnormal_foot_pigmentation0.46987704
91MP0005452_abnormal_adipose_tissue0.46508111
92MP0005253_abnormal_eye_physiology0.46128408
93MP0000631_abnormal_neuroendocrine_gland0.45985072
94MP0002396_abnormal_hematopoietic_system0.45611289
95MP0002092_abnormal_eye_morphology0.45566436
96MP0002067_abnormal_sensory_capabilities0.45246983
97MP0002557_abnormal_social/conspecific_i0.45087946
98MP0004197_abnormal_fetal_growth/weight/0.41814248
99MP0005397_hematopoietic_system_phenotyp0.41588363
100MP0001545_abnormal_hematopoietic_system0.41588363

Predicted human phenotypes

RankGene SetZ-score
1Osteolytic defects of the phalanges of the hand (HP:0009771)9.36337284
2Osteolytic defects of the hand bones (HP:0009699)9.36337284
3Abnormality of the parathyroid morphology (HP:0011766)7.23282175
4Poor speech (HP:0002465)6.51487263
5Increased hepatocellular lipid droplets (HP:0006565)5.27213638
6Hyperventilation (HP:0002883)5.10843881
7Nephroblastoma (Wilms tumor) (HP:0002667)4.72673156
8Cerebellar dysplasia (HP:0007033)4.72172797
9Hyperparathyroidism (HP:0000843)4.59189864
10Lipid accumulation in hepatocytes (HP:0006561)4.54707251
11Renal Fanconi syndrome (HP:0001994)4.53987020
12Embryonal renal neoplasm (HP:0011794)4.48487174
13Wormian bones (HP:0002645)4.17241103
14Esotropia (HP:0000565)4.15093110
15Difficulty running (HP:0009046)3.93830328
16Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.80445934
17Abnormality of the aortic arch (HP:0012303)3.70157330
18Short 4th metacarpal (HP:0010044)3.66787069
19Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.66787069
20Abnormal cortical bone morphology (HP:0003103)3.47277484
21Exertional dyspnea (HP:0002875)3.40690133
22Osteomyelitis (HP:0002754)3.38334226
23Intellectual disability, severe (HP:0010864)3.17481237
24Abnormality of the 4th metacarpal (HP:0010012)3.13910095
25Hamartoma (HP:0010566)3.10772393
26Increased intramyocellular lipid droplets (HP:0012240)3.10707055
27Respiratory difficulties (HP:0002880)3.00379597
28Tapered finger (HP:0001182)2.99681961
29Abnormality of renal resorption (HP:0011038)2.92034825
30Embryonal neoplasm (HP:0002898)2.84369473
31Neoplasm of the adrenal cortex (HP:0100641)2.75310056
32Aplasia/Hypoplasia of the fovea (HP:0008060)2.71044757
33Hypoplasia of the fovea (HP:0007750)2.71044757
34Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.66837620
35Absent speech (HP:0001344)2.64262810
36Retinal atrophy (HP:0001105)2.55742499
37Limb dystonia (HP:0002451)2.50118957
38Increased muscle lipid content (HP:0009058)2.46405960
39Prostate neoplasm (HP:0100787)2.46274989
40Neoplasm of the thyroid gland (HP:0100031)2.44830411
41Hyperglycinuria (HP:0003108)2.42882395
42Psychosis (HP:0000709)2.42817864
43Renal cell carcinoma (HP:0005584)2.37022819
44Gait imbalance (HP:0002141)2.27074143
45Rib fusion (HP:0000902)2.20173964
46Congenital primary aphakia (HP:0007707)2.14824255
47Colon cancer (HP:0003003)2.09800160
48Abnormality of urine glucose concentration (HP:0011016)2.09114725
49Glycosuria (HP:0003076)2.09114725
50Hypercalcemia (HP:0003072)2.08910318
51Abnormality of the fovea (HP:0000493)2.07505677
52Broad-based gait (HP:0002136)2.07252135
53Renal hypoplasia (HP:0000089)2.05716301
54Ectopic kidney (HP:0000086)2.02933884
55Hyperphosphaturia (HP:0003109)2.01502172
56Cerebral edema (HP:0002181)2.00405995
57Autoamputation (HP:0001218)10.3712129
58Amblyopia (HP:0000646)10.2570776
59Facial hemangioma (HP:0000329)1.99456775
60Renal dysplasia (HP:0000110)1.98782038
61Urinary incontinence (HP:0000020)1.96102067
62Mitochondrial inheritance (HP:0001427)1.94498069
63Anterior segment dysgenesis (HP:0007700)1.92079488
64Partial agenesis of the corpus callosum (HP:0001338)1.88874449
65Microglossia (HP:0000171)1.87682663
66Adrenal hypoplasia (HP:0000835)1.86371625
67Spinal muscular atrophy (HP:0007269)1.85951030
68Nephrogenic diabetes insipidus (HP:0009806)1.84583901
69Hyperkalemia (HP:0002153)1.82171961
70Severe Myopia (HP:0011003)1.79801435
71Patent foramen ovale (HP:0001655)1.78906341
72Hypermetropia (HP:0000540)1.76329596
73Pancreatitis (HP:0001733)1.75952388
74Abnormal lung lobation (HP:0002101)1.75920277
75Decreased circulating renin level (HP:0003351)1.75671683
76Abnormal hair whorl (HP:0010721)1.75666133
77Aplasia/Hypoplasia of the macula (HP:0008059)1.75551866
78Medial flaring of the eyebrow (HP:0010747)1.74010684
79Focal motor seizures (HP:0011153)1.73552176
80Genetic anticipation (HP:0003743)1.73044833
81Oligodactyly (HP:0012165)1.72861535
823-Methylglutaconic aciduria (HP:0003535)1.70823817
83Tetraparesis (HP:0002273)1.67820650
84Aplasia/Hypoplasia of the lens (HP:0008063)1.67656683
85Optic nerve hypoplasia (HP:0000609)1.67364040
86Abnormality of chloride homeostasis (HP:0011422)1.66795312
87Genital tract atresia (HP:0001827)1.64697837
88Aplasia/Hypoplasia affecting the retina (HP:0008061)1.62694784
89Abnormal pancreas size (HP:0012094)1.62556932
90Bilateral microphthalmos (HP:0007633)1.61941101
91Abnormality of the phalanges of the hallux (HP:0010057)1.61568898
92Vaginal atresia (HP:0000148)1.61349446
93Pachygyria (HP:0001302)1.56856611
94Abnormal urine phosphate concentration (HP:0012599)1.55954942
95Papillary thyroid carcinoma (HP:0002895)1.54050869
96Focal seizures (HP:0007359)1.51616825
97Bony spicule pigmentary retinopathy (HP:0007737)1.50839253
98Poor coordination (HP:0002370)1.48290029
99Neoplasm of the pancreas (HP:0002894)1.47553785
100Left ventricular hypertrophy (HP:0001712)1.47329497

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE17.73745703
2BRSK15.39268553
3PBK3.30341907
4SMG12.81863407
5MAP3K102.77443888
6VRK22.76751564
7CASK2.74519567
8TAF12.68934911
9NEK92.04527253
10BRSK211.0003451
11CDK41.49157415
12PNCK1.42645413
13NUAK11.33447869
14EPHB21.32432283
15BMPR1B1.21165047
16CAMK1G1.06657660
17MAP3K130.95004893
18MKNK20.94037071
19WNK30.92912412
20HIPK20.89060944
21EIF2AK20.84920167
22UHMK10.83119748
23AURKA0.81767685
24MAP3K120.75736257
25MARK10.72853622
26MAPKAPK50.71031721
27DYRK30.66817652
28TAOK30.63650426
29WNK40.59045398
30DYRK20.57254825
31GRK50.56557248
32BRD40.55694457
33VRK10.55337542
34NME10.54351932
35MAP3K70.52223495
36MELK0.51463010
37CSNK1G20.41677274
38CAMK1D0.41254659
39CSNK1A1L0.40610942
40PINK10.40416751
41TNIK0.40168593
42CAMKK20.40166766
43RPS6KA10.39319132
44SIK20.37240517
45CSNK1G30.37121670
46CSNK1G10.33904300
47RPS6KA40.32939970
48MKNK10.31233683
49STK110.31206602
50ZAK0.31072398
51PLK10.30016517
52CDK50.27701519
53CDK30.26110744
54SGK20.26002983
55CDK90.24294818
56FGR0.22492837
57ADRBK20.22488877
58MST40.21336651
59CSNK1D0.21148286
60TAOK10.20619074
61MAPK70.20438717
62MAPK40.20177032
63MAP3K140.18089274
64PRKG10.17076180
65MAP3K110.14952693
66EPHA30.14929550
67DYRK1B0.13758047
68PRKAA20.13610807
69TYRO30.12586704
70GSK3A0.12498683
71CAMK40.12058365
72SGK4940.11417419
73SGK2230.11417419
74PRKAA10.09601907
75FGFR40.09145162
76FER0.08832737
77MAPK140.07247960
78YES10.06977271
79CAMK2B0.06962111
80ERBB20.06228376
81JAK30.05864616
82EPHB10.04598701
83PLK30.04186713
84EGFR0.03262109
85PRKCA0.03254199
86RPS6KA60.02606176
87ICK0.02238181
88DAPK30.01920555
89PAK40.01887120
90DYRK1A0.01645693
91SIK10.01584319
92WNK10.00779841
93CAMKK10.00724214
94RPS6KL10.00541918
95RPS6KC10.00541918
96GRK10.00174347
97MAP2K4-0.0197546
98SGK1-0.0045138
99CAMK1-0.0034916
100CSNK2A1-0.0008700

Predicted pathways (KEGG)

RankGene SetZ-score
1Regulation of autophagy_Homo sapiens_hsa041408.01402836
2Cell cycle_Homo sapiens_hsa041103.05335953
3ABC transporters_Homo sapiens_hsa020103.04561277
4Steroid hormone biosynthesis_Homo sapiens_hsa001402.47476719
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.14547315
6beta-Alanine metabolism_Homo sapiens_hsa004102.11575158
7Inositol phosphate metabolism_Homo sapiens_hsa005622.02575608
8Type II diabetes mellitus_Homo sapiens_hsa049301.97351560
9Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.95066784
10Basal cell carcinoma_Homo sapiens_hsa052171.90464472
11Chemical carcinogenesis_Homo sapiens_hsa052041.79232429
12Phototransduction_Homo sapiens_hsa047441.67680792
13Circadian entrainment_Homo sapiens_hsa047131.43833258
14Axon guidance_Homo sapiens_hsa043601.41239384
15Glutathione metabolism_Homo sapiens_hsa004801.35394386
16Propanoate metabolism_Homo sapiens_hsa006401.35157269
17Olfactory transduction_Homo sapiens_hsa047401.29357911
18Pancreatic secretion_Homo sapiens_hsa049721.27008494
19Protein export_Homo sapiens_hsa030601.26203203
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.25862633
21Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.25517502
22Notch signaling pathway_Homo sapiens_hsa043301.24652160
23Fatty acid degradation_Homo sapiens_hsa000711.21940631
24Retinol metabolism_Homo sapiens_hsa008301.19955030
25PPAR signaling pathway_Homo sapiens_hsa033201.18723363
26Nicotine addiction_Homo sapiens_hsa050331.17909129
27Renin secretion_Homo sapiens_hsa049241.15609921
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.14126481
29FoxO signaling pathway_Homo sapiens_hsa040681.11798337
30cAMP signaling pathway_Homo sapiens_hsa040241.10353899
31Aldosterone synthesis and secretion_Homo sapiens_hsa049251.09640334
32Calcium signaling pathway_Homo sapiens_hsa040201.03492248
33Dopaminergic synapse_Homo sapiens_hsa047281.00284460
34Steroid biosynthesis_Homo sapiens_hsa001000.96755079
35Phosphatidylinositol signaling system_Homo sapiens_hsa040700.94083742
36TGF-beta signaling pathway_Homo sapiens_hsa043500.90980444
37Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.88592530
38Glutamatergic synapse_Homo sapiens_hsa047240.85932660
39Phagosome_Homo sapiens_hsa041450.85367337
40Morphine addiction_Homo sapiens_hsa050320.83999151
41Tuberculosis_Homo sapiens_hsa051520.82517037
42Wnt signaling pathway_Homo sapiens_hsa043100.82399750
43Sulfur relay system_Homo sapiens_hsa041220.82142426
44Cocaine addiction_Homo sapiens_hsa050300.80554813
45mTOR signaling pathway_Homo sapiens_hsa041500.79874217
46Glycerolipid metabolism_Homo sapiens_hsa005610.77074017
47Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76215136
48RNA polymerase_Homo sapiens_hsa030200.75865658
49Salivary secretion_Homo sapiens_hsa049700.73897520
50Serotonergic synapse_Homo sapiens_hsa047260.71764721
51Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.70719336
52Fatty acid metabolism_Homo sapiens_hsa012120.69992434
53Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69760664
54mRNA surveillance pathway_Homo sapiens_hsa030150.68924527
55Maturity onset diabetes of the young_Homo sapiens_hsa049500.68613703
56Amphetamine addiction_Homo sapiens_hsa050310.67663080
57Ether lipid metabolism_Homo sapiens_hsa005650.66698108
58Cholinergic synapse_Homo sapiens_hsa047250.65892688
59Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.65695431
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62207509
61AMPK signaling pathway_Homo sapiens_hsa041520.62178870
62Fat digestion and absorption_Homo sapiens_hsa049750.61799369
63Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61249485
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61214761
65PI3K-Akt signaling pathway_Homo sapiens_hsa041510.60831704
66Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.59826187
67AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59653130
68Cardiac muscle contraction_Homo sapiens_hsa042600.59509781
69MicroRNAs in cancer_Homo sapiens_hsa052060.59135245
70Sulfur metabolism_Homo sapiens_hsa009200.57484350
71Hedgehog signaling pathway_Homo sapiens_hsa043400.56524654
72Osteoclast differentiation_Homo sapiens_hsa043800.55750592
73Thyroid hormone synthesis_Homo sapiens_hsa049180.55457066
74Melanogenesis_Homo sapiens_hsa049160.53773406
75Huntingtons disease_Homo sapiens_hsa050160.52900754
76Fatty acid elongation_Homo sapiens_hsa000620.52782713
77Insulin secretion_Homo sapiens_hsa049110.51590439
78Gastric acid secretion_Homo sapiens_hsa049710.49635920
79Antigen processing and presentation_Homo sapiens_hsa046120.48456680
80Viral carcinogenesis_Homo sapiens_hsa052030.47843570
81Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.45640595
82Glucagon signaling pathway_Homo sapiens_hsa049220.43269105
83Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.42979156
84Prostate cancer_Homo sapiens_hsa052150.42073810
85Protein digestion and absorption_Homo sapiens_hsa049740.39448608
86Adherens junction_Homo sapiens_hsa045200.39401514
87Taste transduction_Homo sapiens_hsa047420.36786397
88Ras signaling pathway_Homo sapiens_hsa040140.36601343
89Oxidative phosphorylation_Homo sapiens_hsa001900.35702266
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32315902
91Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.31469341
92cGMP-PKG signaling pathway_Homo sapiens_hsa040220.31111139
93Alzheimers disease_Homo sapiens_hsa050100.31041104
94Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.29554852
95Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.29196793
96Nitrogen metabolism_Homo sapiens_hsa009100.27531106
97Parkinsons disease_Homo sapiens_hsa050120.26832686
98GABAergic synapse_Homo sapiens_hsa047270.25619300
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.24671179
100Selenocompound metabolism_Homo sapiens_hsa004500.24263983

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