EBF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.44802832
2regulation of chromatin binding (GO:0035561)5.24997098
3limb bud formation (GO:0060174)5.08383035
4sensory perception of smell (GO:0007608)4.77222291
5presynaptic membrane organization (GO:0097090)4.40218084
6axonal fasciculation (GO:0007413)4.38879415
7positive regulation of phosphoprotein phosphatase activity (GO:0032516)4.37755902
8nucleobase catabolic process (GO:0046113)4.26429628
9dendritic spine morphogenesis (GO:0060997)4.25107345
10cellular response to prostaglandin stimulus (GO:0071379)4.21042441
11regulation of cell communication by electrical coupling (GO:0010649)4.19675811
12lateral sprouting from an epithelium (GO:0060601)4.19673109
13neural tube formation (GO:0001841)4.13818874
14cAMP catabolic process (GO:0006198)4.07671416
15auditory behavior (GO:0031223)4.07447011
16negative regulation of cytosolic calcium ion concentration (GO:0051481)4.06507087
17protein polyglutamylation (GO:0018095)4.03305816
18presynaptic membrane assembly (GO:0097105)4.01152717
19sympathetic nervous system development (GO:0048485)3.99381768
20neuron recognition (GO:0008038)3.97431544
21histone H2B ubiquitination (GO:0033523)3.94927458
22negative regulation of axon guidance (GO:1902668)3.90424709
23adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.86207570
24central nervous system projection neuron axonogenesis (GO:0021952)3.81879850
25sequestering of actin monomers (GO:0042989)3.79949294
26mesenchymal-epithelial cell signaling (GO:0060638)3.79164415
27negative regulation of transcription regulatory region DNA binding (GO:2000678)3.77372942
28cyclic nucleotide catabolic process (GO:0009214)3.71322123
29ovulation cycle (GO:0042698)3.70101881
30sensory perception of chemical stimulus (GO:0007606)3.67460438
31eyelid development in camera-type eye (GO:0061029)3.64111039
32ganglion development (GO:0061548)3.63987264
33somite development (GO:0061053)3.60898031
34regulation of synapse structural plasticity (GO:0051823)3.55376579
35behavioral response to ethanol (GO:0048149)3.52986933
36olfactory bulb development (GO:0021772)3.51782076
37regulation of axon guidance (GO:1902667)3.45581931
38epithelial cell differentiation involved in kidney development (GO:0035850)3.45547266
39positive regulation of DNA-templated transcription, elongation (GO:0032786)3.40237646
40regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.39039292
41negative regulation of dendrite morphogenesis (GO:0050774)3.33961832
42synapse assembly (GO:0007416)3.33205568
43neurofilament cytoskeleton organization (GO:0060052)3.32762447
44pyrimidine nucleobase catabolic process (GO:0006208)3.29551121
45postsynaptic membrane organization (GO:0001941)3.27912150
46dendrite morphogenesis (GO:0048813)3.26213136
47neuron cell-cell adhesion (GO:0007158)3.25774569
48gamma-aminobutyric acid transport (GO:0015812)3.25378525
49facial nerve structural organization (GO:0021612)3.20878867
50regulation of relaxation of muscle (GO:1901077)3.20708026
51vocalization behavior (GO:0071625)3.17632761
52membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.16611128
53mechanosensory behavior (GO:0007638)3.16025511
54cGMP-mediated signaling (GO:0019934)3.15097138
55cornea development in camera-type eye (GO:0061303)3.13916593
56negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 3.13277970
57negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.12556460
58spinal cord motor neuron differentiation (GO:0021522)3.09139078
59neurotransmitter-gated ion channel clustering (GO:0072578)3.09084954
60urinary tract smooth muscle contraction (GO:0014848)3.07900985
61regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.07379787
62protein localization to synapse (GO:0035418)3.04944102
63neuronal ion channel clustering (GO:0045161)3.01210245
64transmission of nerve impulse (GO:0019226)3.01047779
65inositol phosphate catabolic process (GO:0071545)2.99986837
66negative regulation of axon extension (GO:0030517)2.99216988
67regulation of non-canonical Wnt signaling pathway (GO:2000050)2.98770047
68craniofacial suture morphogenesis (GO:0097094)2.98361120
69snRNA transcription (GO:0009301)2.96251069
70neuronal action potential (GO:0019228)2.96056378
71renal system development (GO:0072001)2.95642383
72short-term memory (GO:0007614)2.95448815
73spinal cord development (GO:0021510)2.95246129
74metanephric mesenchyme development (GO:0072075)2.94373232
75kidney mesenchyme development (GO:0072074)2.94175850
76peristalsis (GO:0030432)2.93496569
77negative regulation of mast cell activation (GO:0033004)2.92485735
78intraciliary transport (GO:0042073)2.90487545
79ionotropic glutamate receptor signaling pathway (GO:0035235)2.89754796
80response to prostaglandin E (GO:0034695)2.89727244
81V(D)J recombination (GO:0033151)2.89673335
82neuromuscular synaptic transmission (GO:0007274)2.89343460
83glomerulus development (GO:0032835)2.88357053
84protein-DNA complex disassembly (GO:0032986)2.83369410
85nucleosome disassembly (GO:0006337)2.83369410
86regulation of NFAT protein import into nucleus (GO:0051532)2.83025575
87nonmotile primary cilium assembly (GO:0035058)2.82932027
88G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.82764699
89axon extension (GO:0048675)2.82278752
90neural crest cell development (GO:0014032)2.81485802
91response to auditory stimulus (GO:0010996)2.80928667
92positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.80446566
93regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.79214011
94adult walking behavior (GO:0007628)2.79199129
95regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.78450950
96regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.77098286
97negative regulation of dendrite development (GO:2000171)2.76664092
98behavioral response to pain (GO:0048266)2.76491362
99nerve growth factor signaling pathway (GO:0038180)2.76177962
100mesenchymal cell development (GO:0014031)2.75647085
101regulation of cilium movement (GO:0003352)2.74762656
102sequestering of extracellular ligand from receptor (GO:0035581)2.72534672
103forebrain neuron differentiation (GO:0021879)2.70048326
104calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.69804338
105radial glial cell differentiation (GO:0060019)2.69307122
106neuron projection extension involved in neuron projection guidance (GO:1902284)2.68564425
107axon extension involved in axon guidance (GO:0048846)2.68564425
108tachykinin receptor signaling pathway (GO:0007217)2.66013198
109positive regulation of gastrulation (GO:2000543)2.65775657
110cardiac ventricle formation (GO:0003211)2.64928822
111negative regulation of glycogen biosynthetic process (GO:0045719)2.64884086
112bone trabecula formation (GO:0060346)2.64821425
113negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.64017559
114regulation of histone deacetylation (GO:0031063)2.63793455
115cerebellar Purkinje cell differentiation (GO:0021702)2.63791654
116positive regulation of granulocyte differentiation (GO:0030854)2.62960470
117regulation of dopamine secretion (GO:0014059)2.60411382
118membrane depolarization during action potential (GO:0086010)2.59977149
119sensory perception of taste (GO:0050909)2.59847870
120establishment of mitochondrion localization (GO:0051654)2.59536365
121negative regulation of axonogenesis (GO:0050771)2.59255026
122neuron migration (GO:0001764)2.57506465
123regulation of action potential (GO:0098900)2.57454240
124glutamate receptor signaling pathway (GO:0007215)2.55159499
125positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.55091462
126regulation of protein kinase A signaling (GO:0010738)2.53068574
127detection of light stimulus involved in sensory perception (GO:0050962)2.51827092
128detection of light stimulus involved in visual perception (GO:0050908)2.51827092
129regulation of cAMP-dependent protein kinase activity (GO:2000479)2.51209032
130head development (GO:0060322)2.50525305
131axonogenesis (GO:0007409)2.50139098
132regulation of protein heterodimerization activity (GO:0043497)2.49855028
133kidney morphogenesis (GO:0060993)2.49615645
134protein heterotrimerization (GO:0070208)2.49420191
135cranial nerve structural organization (GO:0021604)2.48570737
136regulation of axon extension (GO:0030516)2.48104132
137regulation of extent of cell growth (GO:0061387)2.47727943
138regulation of synaptic transmission, glutamatergic (GO:0051966)2.47313856
139cellular response to monoamine stimulus (GO:0071868)2.47291090
140cellular response to catecholamine stimulus (GO:0071870)2.47291090
141regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)2.47138160
142cell migration in hindbrain (GO:0021535)2.46039430
143negative chemotaxis (GO:0050919)2.45622713
144neuron-neuron synaptic transmission (GO:0007270)2.45525231
145negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage (GO:1902230)2.44317734
146atrial cardiac muscle cell action potential (GO:0086014)2.44070703
147synapse organization (GO:0050808)2.43410314
148regulation of synaptic transmission, GABAergic (GO:0032228)2.43159588
149positive regulation of synapse assembly (GO:0051965)2.43103873
150protein localization to cilium (GO:0061512)2.43099266
151planar cell polarity pathway involved in neural tube closure (GO:0090179)2.42152723
152sulfation (GO:0051923)2.42022291
153negative regulation of microtubule polymerization (GO:0031115)2.41248140
154cardiac chamber formation (GO:0003207)2.40702085
155synaptic transmission, cholinergic (GO:0007271)2.40538251
156substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.40368552
157substrate-independent telencephalic tangential migration (GO:0021826)2.40368552
158response to histamine (GO:0034776)2.40297736
159regulation of sequestering of triglyceride (GO:0010889)2.40045790
160endothelial cell differentiation (GO:0045446)2.39993881
161central nervous system neuron axonogenesis (GO:0021955)2.39436530
162negative regulation of glial cell proliferation (GO:0060253)2.39014629
163neuronal action potential propagation (GO:0019227)2.38819906
164regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.38816071
165negative regulation of axon extension involved in axon guidance (GO:0048843)2.38486173
166retinal ganglion cell axon guidance (GO:0031290)2.38306920
167regulation of axon extension involved in axon guidance (GO:0048841)2.37797035
168stem cell development (GO:0048864)2.37464598
169lymph vessel development (GO:0001945)2.37005470
170regulation of platelet aggregation (GO:0090330)2.35926962
171negative regulation of calcium ion transport into cytosol (GO:0010523)2.35830982
172regulation of protein deacetylation (GO:0090311)2.35176575
173omega-hydroxylase P450 pathway (GO:0097267)2.34970453
174regulation of interferon-gamma biosynthetic process (GO:0045072)2.33931715
175auditory receptor cell differentiation (GO:0042491)2.33801751
176germ cell migration (GO:0008354)2.33427815
177positive regulation of cardiac muscle cell differentiation (GO:2000727)2.33184531
178regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.32358606
179mitochondrion transport along microtubule (GO:0047497)2.31135728
180establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.31135728

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.73485845
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.23941818
3RBPJ_22232070_ChIP-Seq_NCS_Mouse4.41026482
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.18386696
5GBX2_23144817_ChIP-Seq_PC3_Human3.08933533
6SMAD_19615063_ChIP-ChIP_OVARY_Human2.77308911
7* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.63169119
8* EED_16625203_ChIP-ChIP_MESCs_Mouse2.60579051
9* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.54943663
10* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.54817071
11* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.54817071
12TP63_19390658_ChIP-ChIP_HaCaT_Human2.48671503
13NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.42424111
14BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.40354948
15* EZH2_27304074_Chip-Seq_ESCs_Mouse2.29660152
16* RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.21204841
17* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.19665661
18* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.15711629
19TAF15_26573619_Chip-Seq_HEK293_Human2.10565083
20* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.08536975
21* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.05768539
22* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.03531263
23* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.01416022
24* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.00889384
25WT1_19549856_ChIP-ChIP_CCG9911_Human1.98749304
26* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.97522951
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.96719331
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.96636135
29* RNF2_27304074_Chip-Seq_ESCs_Mouse1.94477832
30* REST_21632747_ChIP-Seq_MESCs_Mouse1.78166552
31FUS_26573619_Chip-Seq_HEK293_Human1.78055482
32VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.74727906
33P300_19829295_ChIP-Seq_ESCs_Human1.74300136
34ZNF274_21170338_ChIP-Seq_K562_Hela1.73620749
35* CBX2_27304074_Chip-Seq_ESCs_Mouse1.72861828
36EWS_26573619_Chip-Seq_HEK293_Human1.66175105
37CDX2_19796622_ChIP-Seq_MESCs_Mouse1.65807573
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.64716090
39* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.64134283
40* AHR_22903824_ChIP-Seq_MCF-7_Human1.62010763
41* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.59376944
42POU5F1_16153702_ChIP-ChIP_HESCs_Human1.58786187
43* EZH2_27294783_Chip-Seq_ESCs_Mouse1.55961830
44FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.53717012
45* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.53607544
46TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47127919
47ZNF217_24962896_ChIP-Seq_MCF-7_Human1.45155927
48RNF2_27304074_Chip-Seq_NSC_Mouse1.44057517
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.43156474
50POU3F2_20337985_ChIP-ChIP_501MEL_Human1.41732441
51IKZF1_21737484_ChIP-ChIP_HCT116_Human1.38775183
52EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.38524886
53* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.36240814
54* AR_25329375_ChIP-Seq_VCAP_Human1.36166701
55AR_21572438_ChIP-Seq_LNCaP_Human1.33816261
56* RING1B_27294783_Chip-Seq_ESCs_Mouse1.33524720
57* ARNT_22903824_ChIP-Seq_MCF-7_Human1.32522346
58ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.32006173
59* SMAD4_21799915_ChIP-Seq_A2780_Human1.29446220
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28801709
61ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.28747340
62IGF1R_20145208_ChIP-Seq_DFB_Human1.26952889
63OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26437895
64* RING1B_27294783_Chip-Seq_NPCs_Mouse1.26107668
65TP53_18474530_ChIP-ChIP_U2OS_Human1.23606163
66BCAT_22108803_ChIP-Seq_LS180_Human1.23295594
67* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22880150
68* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22880150
69* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.22517646
70GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21713063
71ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.21060251
72REST_18959480_ChIP-ChIP_MESCs_Mouse1.20757279
73* RUNX2_22187159_ChIP-Seq_PCA_Human1.17026791
74IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.15350490
75CBP_20019798_ChIP-Seq_JUKART_Human1.15350490
76SMAD3_21741376_ChIP-Seq_EPCs_Human1.15118668
77AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13508989
78* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13242654
79CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.12089004
80KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.10412049
81* KDM2B_26808549_Chip-Seq_REH_Human1.10287818
82ER_23166858_ChIP-Seq_MCF-7_Human1.09421183
83MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08249230
84* SOX2_21211035_ChIP-Seq_LN229_Gbm1.07877145
85* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07617787
86* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.04718670
87* TP53_20018659_ChIP-ChIP_R1E_Mouse1.03104901
88NR3C1_23031785_ChIP-Seq_PC12_Mouse1.02312706
89* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.02182372
90ISL1_27105846_Chip-Seq_CPCs_Mouse0.99867419
91CTBP2_25329375_ChIP-Seq_LNCAP_Human0.99135721
92DROSHA_22980978_ChIP-Seq_HELA_Human0.97565337
93EP300_21415370_ChIP-Seq_HL-1_Mouse0.97304150
94RXR_22108803_ChIP-Seq_LS180_Human0.97256642
95EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96796467
96SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96245925
97CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96032848
98TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.95107091
99MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94650498
100OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.93983519
101TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93663596
102TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92747277
103NANOG_18555785_Chip-Seq_ESCs_Mouse0.92160976
104* PRDM14_20953172_ChIP-Seq_ESCs_Human0.91297944
105* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91161576
106HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.90252458
107TRIM28_21343339_ChIP-Seq_HEK293_Human0.89783646
108* TCF4_23295773_ChIP-Seq_U87_Human0.89547203
109* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88220428
110E2F1_18555785_Chip-Seq_ESCs_Mouse0.88150363
111FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.86615752
112* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.86584245
113SUZ12_18555785_Chip-Seq_ESCs_Mouse0.86295532
114UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.86136584
115ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.85636606
116* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.85546491
117* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.85190305
118TAL1_26923725_Chip-Seq_HPCs_Mouse0.83805587
119WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.83142465
120P53_22387025_ChIP-Seq_ESCs_Mouse0.82987727
121VDR_22108803_ChIP-Seq_LS180_Human0.82878660
122* STAT3_23295773_ChIP-Seq_U87_Human0.82256522

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008789_abnormal_olfactory_epithelium5.13831103
2MP0005394_taste/olfaction_phenotype4.22270162
3MP0005499_abnormal_olfactory_system4.22270162
4MP0001984_abnormal_olfaction3.80259673
5MP0005645_abnormal_hypothalamus_physiol3.76008551
6MP0002822_catalepsy3.59957759
7MP0006276_abnormal_autonomic_nervous2.92897897
8MP0000372_irregular_coat_pigmentation2.68091670
9MP0002938_white_spotting2.67963098
10MP0001188_hyperpigmentation2.63096192
11MP0002102_abnormal_ear_morphology2.62844130
12MP0000569_abnormal_digit_pigmentation2.53663625
13MP0002638_abnormal_pupillary_reflex2.29361173
14MP0005503_abnormal_tendon_morphology2.26851925
15MP0009250_abnormal_appendicular_skeleto2.25256792
16MP0002751_abnormal_autonomic_nervous2.22124431
17MP0004859_abnormal_synaptic_plasticity2.21483563
18MP0003011_delayed_dark_adaptation2.17266929
19MP0004134_abnormal_chest_morphology2.14709527
20MP0002160_abnormal_reproductive_system2.09989961
21MP0001542_abnormal_bone_strength2.07291093
22MP0010386_abnormal_urinary_bladder1.97824108
23MP0002184_abnormal_innervation1.89796948
24MP0003635_abnormal_synaptic_transmissio1.86773149
25MP0009745_abnormal_behavioral_response1.79313364
26MP0004270_analgesia1.79104669
27MP0003787_abnormal_imprinting1.78717602
28MP0001986_abnormal_taste_sensitivity1.75105324
29MP0002233_abnormal_nose_morphology1.72417399
30MP0000049_abnormal_middle_ear1.72351545
31* MP0000778_abnormal_nervous_system1.72236547
32MP0001529_abnormal_vocalization1.65899979
33MP0005275_abnormal_skin_tensile1.64425152
34MP0009046_muscle_twitch1.62318759
35MP0008877_abnormal_DNA_methylation1.60908313
36MP0001299_abnormal_eye_distance/1.58739786
37MP0000003_abnormal_adipose_tissue1.57242009
38MP0002063_abnormal_learning/memory/cond1.56864436
39MP0000566_synostosis1.56249794
40MP0002909_abnormal_adrenal_gland1.53949059
41MP0008438_abnormal_cutaneous_collagen1.53151278
42MP0002249_abnormal_larynx_morphology1.52558805
43MP0002928_abnormal_bile_duct1.50867523
44MP0005075_abnormal_melanosome_morpholog1.50147136
45MP0004885_abnormal_endolymph1.49387178
46MP0005409_darkened_coat_color1.46191231
47MP0002572_abnormal_emotion/affect_behav1.43895260
48MP0004130_abnormal_muscle_cell1.42102953
49MP0003385_abnormal_body_wall1.41102521
50MP0002138_abnormal_hepatobiliary_system1.40942295
51MP0005257_abnormal_intraocular_pressure1.40360105
52MP0000955_abnormal_spinal_cord1.38289057
53MP0002064_seizures1.37291011
54MP0002932_abnormal_joint_morphology1.36859804
55MP0005171_absent_coat_pigmentation1.36408822
56MP0001970_abnormal_pain_threshold1.34953376
57MP0001440_abnormal_grooming_behavior1.34464050
58MP0000015_abnormal_ear_pigmentation1.33068120
59MP0002177_abnormal_outer_ear1.31777230
60MP0002735_abnormal_chemical_nociception1.31075319
61MP0002734_abnormal_mechanical_nocicepti1.30832028
62MP0003942_abnormal_urinary_system1.30343976
63MP0005386_behavior/neurological_phenoty1.30013401
64MP0004924_abnormal_behavior1.30013401
65MP0005551_abnormal_eye_electrophysiolog1.29959098
66MP0004133_heterotaxia1.29398138
67MP0002116_abnormal_craniofacial_bone1.28261574
68MP0002557_abnormal_social/conspecific_i1.28058081
69MP0003315_abnormal_perineum_morphology1.24403149
70MP0002733_abnormal_thermal_nociception1.23812783
71MP0005389_reproductive_system_phenotype1.23546966
72MP0001293_anophthalmia1.23169843
73MP0005670_abnormal_white_adipose1.21989265
74MP0005187_abnormal_penis_morphology1.21014017
75MP0003755_abnormal_palate_morphology1.20356439
76MP0001879_abnormal_lymphatic_vessel1.19068468
77MP0003122_maternal_imprinting1.18786814
78MP0004145_abnormal_muscle_electrophysio1.18527921
79MP0004811_abnormal_neuron_physiology1.17510058
80MP0003935_abnormal_craniofacial_develop1.17501451
81MP0002876_abnormal_thyroid_physiology1.16321149
82MP0002282_abnormal_trachea_morphology1.11177623
83MP0009379_abnormal_foot_pigmentation1.11165117
84MP0005623_abnormal_meninges_morphology1.10826500
85MP0003938_abnormal_ear_development1.10730554
86MP0005508_abnormal_skeleton_morphology1.09756622
87MP0002752_abnormal_somatic_nervous1.09509201
88MP0003121_genomic_imprinting1.08955257
89MP0003283_abnormal_digestive_organ1.08478152
90MP0005253_abnormal_eye_physiology1.07627518
91MP0002653_abnormal_ependyma_morphology1.07531800
92MP0000026_abnormal_inner_ear1.06727604
93MP0001905_abnormal_dopamine_level1.06150837
94MP0002009_preneoplasia1.06013049
95MP0004142_abnormal_muscle_tone1.03690274
96MP0005174_abnormal_tail_pigmentation1.01948888
97MP0006072_abnormal_retinal_apoptosis1.01805354
98* MP0003861_abnormal_nervous_system0.99465170
99MP0004381_abnormal_hair_follicle0.98178287
100MP0001502_abnormal_circadian_rhythm0.97844036
101MP0002882_abnormal_neuron_morphology0.97671062
102MP0005195_abnormal_posterior_eye0.97176182
103MP0000751_myopathy0.96011383
104MP0002109_abnormal_limb_morphology0.94551684
105MP0000538_abnormal_urinary_bladder0.93011301
106MP0001968_abnormal_touch/_nociception0.91720737
107MP0002108_abnormal_muscle_morphology0.91096882
108MP0004858_abnormal_nervous_system0.90769127
109MP0003119_abnormal_digestive_system0.90689490
110MP0002736_abnormal_nociception_after0.90475958
111MP0003937_abnormal_limbs/digits/tail_de0.89700477
112MP0003890_abnormal_embryonic-extraembry0.89297008
113MP0004215_abnormal_myocardial_fiber0.89275128
114MP0000427_abnormal_hair_cycle0.88600563
115MP0000534_abnormal_ureter_morphology0.87502208
116MP0008995_early_reproductive_senescence0.87150522
117MP0001286_abnormal_eye_development0.86999475
118MP0000631_abnormal_neuroendocrine_gland0.86798727
119MP0005423_abnormal_somatic_nervous0.86638186
120MP0001340_abnormal_eyelid_morphology0.85431801
121MP0004272_abnormal_basement_membrane0.85373031
122MP0001485_abnormal_pinna_reflex0.84776781
123MP0001958_emphysema0.84760364
124MP0010030_abnormal_orbit_morphology0.84661521
125MP0008569_lethality_at_weaning0.82320940
126MP0002066_abnormal_motor_capabilities/c0.82248922
127MP0000516_abnormal_urinary_system0.81464553
128MP0005367_renal/urinary_system_phenotyp0.81464553
129MP0000013_abnormal_adipose_tissue0.81275820
130MP0002067_abnormal_sensory_capabilities0.81195743
131* MP0002115_abnormal_skeleton_extremities0.80911407
132MP0002132_abnormal_respiratory_system0.80315679
133MP0004742_abnormal_vestibular_system0.79970081
134MP0002114_abnormal_axial_skeleton0.79930277
135MP0005646_abnormal_pituitary_gland0.79560238
136MP0002081_perinatal_lethality0.79325053
137* MP0000163_abnormal_cartilage_morphology0.78676967
138MP0001963_abnormal_hearing_physiology0.78031062
139MP0002272_abnormal_nervous_system0.77883960
140MP0010368_abnormal_lymphatic_system0.77542858
141MP0001919_abnormal_reproductive_system0.77525942
142MP0000432_abnormal_head_morphology0.77435198
143MP0000762_abnormal_tongue_morphology0.75576800
144MP0003959_abnormal_lean_body0.74811622
145MP0004883_abnormal_blood_vessel0.74054489
146MP0009384_cardiac_valve_regurgitation0.73854491
147MP0003136_yellow_coat_color0.71207869
148MP0009703_decreased_birth_body0.70817620
149MP0003279_aneurysm0.70527815
150MP0000647_abnormal_sebaceous_gland0.70483373
151MP0002095_abnormal_skin_pigmentation0.70471217
152* MP0002152_abnormal_brain_morphology0.70154630
153MP0001486_abnormal_startle_reflex0.68979698
154MP0003880_abnormal_central_pattern0.68278445
155* MP0002113_abnormal_skeleton_development0.66859499

Predicted human phenotypes

RankGene SetZ-score
1Hypothermia (HP:0002045)5.83033103
2Midline defect of the nose (HP:0004122)4.36684117
3Trigonocephaly (HP:0000243)4.18871606
4Febrile seizures (HP:0002373)4.05951912
5Xerostomia (HP:0000217)3.77233607
6Abnormality of the parietal bone (HP:0002696)3.64906412
7Ulnar claw (HP:0001178)3.51443489
8Abnormality of the intervertebral disk (HP:0005108)3.39645407
9Thyroiditis (HP:0100646)3.28926279
10Focal motor seizures (HP:0011153)3.19047130
11Broad-based gait (HP:0002136)3.16124369
12Anosmia (HP:0000458)3.14068974
13Concave nail (HP:0001598)3.13039406
14Agammaglobulinemia (HP:0004432)3.11772769
15Asymmetry of the thorax (HP:0001555)3.10214858
16Nasolacrimal duct obstruction (HP:0000579)2.93500579
17Congenital stationary night blindness (HP:0007642)2.90215017
18Pachygyria (HP:0001302)2.88469304
19Abnormality of incisor morphology (HP:0011063)2.86389172
20Bell-shaped thorax (HP:0001591)2.82230220
21Atonic seizures (HP:0010819)2.81156027
22Limb dystonia (HP:0002451)2.81013517
23Pancreatic cysts (HP:0001737)2.77916329
24Bradycardia (HP:0001662)2.73341226
25Myokymia (HP:0002411)2.71920420
26Increased corneal curvature (HP:0100692)2.70670231
27Keratoconus (HP:0000563)2.70670231
28Genetic anticipation (HP:0003743)2.70276713
29Drooling (HP:0002307)2.69906461
30Abnormality of hair growth rate (HP:0011363)2.68022366
31Slow-growing hair (HP:0002217)2.68022366
32Wrist flexion contracture (HP:0001239)2.65888342
33Sparse lateral eyebrow (HP:0005338)2.64888675
34Progressive cerebellar ataxia (HP:0002073)2.64371976
35True hermaphroditism (HP:0010459)2.57838214
36Abnormality of the renal medulla (HP:0100957)2.57187466
37Aplasia/Hypoplasia of the brainstem (HP:0007362)2.56369523
38Hypoplasia of the brainstem (HP:0002365)2.56369523
39Amblyopia (HP:0000646)2.55537744
40Polyphagia (HP:0002591)2.54888918
41Abnormality of the nasolacrimal system (HP:0000614)2.53628925
42Chronic hepatic failure (HP:0100626)2.48278312
43Exotropia (HP:0000577)2.47689739
44Long nose (HP:0003189)2.47660329
45Excessive salivation (HP:0003781)2.46268733
46Hemiparesis (HP:0001269)2.46019425
47Hyperventilation (HP:0002883)2.43937492
48Lissencephaly (HP:0001339)2.43309941
49Large earlobe (HP:0009748)2.42968669
50Gaze-evoked nystagmus (HP:0000640)2.42736788
51Congenital, generalized hypertrichosis (HP:0004540)2.42489338
52Intellectual disability, moderate (HP:0002342)2.41633757
53Abnormality of the columella (HP:0009929)2.40726378
54Abnormality of the lacrimal duct (HP:0011481)2.36349023
55Median cleft lip (HP:0000161)2.34969084
56Gait imbalance (HP:0002141)2.30757717
57Aqueductal stenosis (HP:0002410)2.29860783
58Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.28933037
59Short 4th metacarpal (HP:0010044)2.28933037
60Arthropathy (HP:0003040)2.26540000
61Aplasia cutis congenita (HP:0001057)2.25369341
62Alacrima (HP:0000522)2.25354415
63Deep philtrum (HP:0002002)2.21564302
64White forelock (HP:0002211)2.20124904
65Chorioretinal atrophy (HP:0000533)2.19488302
66Anencephaly (HP:0002323)2.18737554
67Fair hair (HP:0002286)2.17752435
68Epileptic encephalopathy (HP:0200134)2.16556295
69Absence seizures (HP:0002121)2.14144556
70High anterior hairline (HP:0009890)2.12869523
71Verrucae (HP:0200043)2.11930888
72Papilloma (HP:0012740)2.11930888
73Abnormality of dentin (HP:0010299)2.11884061
74Medial flaring of the eyebrow (HP:0010747)2.11220046
75Abnormality of the nasal septum (HP:0000419)2.10267197
76Abnormality of B cell number (HP:0010975)2.09612611
77Inability to walk (HP:0002540)2.08100626
78Prominent supraorbital ridges (HP:0000336)2.07914094
79Heterochromia iridis (HP:0001100)2.07055114
80Nephrogenic diabetes insipidus (HP:0009806)2.07036522
81B lymphocytopenia (HP:0010976)2.05022690
82Abnormality of the incisor (HP:0000676)2.04921822
83Congenital primary aphakia (HP:0007707)2.04469253
84Degeneration of the lateral corticospinal tracts (HP:0002314)2.02886885
85Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.02886885
86Dialeptic seizures (HP:0011146)2.02489171
87Patchy hypopigmentation of hair (HP:0011365)2.01375439
88Abnormality of the corticospinal tract (HP:0002492)2.01329390
89Anterior segment dysgenesis (HP:0007700)2.00524456
90Pendular nystagmus (HP:0012043)2.00354096
91Abnormality of molar (HP:0011077)1.99974936
92Abnormality of molar morphology (HP:0011070)1.99974936
93Increased number of teeth (HP:0011069)1.99898335
94Bony spicule pigmentary retinopathy (HP:0007737)1.99425325
95Abolished electroretinogram (ERG) (HP:0000550)1.98570163
96Striae distensae (HP:0001065)1.98088956
97Absent speech (HP:0001344)1.97386736
98Broad metatarsal (HP:0001783)1.97331112
99Steppage gait (HP:0003376)1.96777517
100Agitation (HP:0000713)1.96428143
101Pancreatic fibrosis (HP:0100732)1.95988128
102Congenital sensorineural hearing impairment (HP:0008527)1.94855578
103Palpebral edema (HP:0100540)1.94388868
104Abnormal eating behavior (HP:0100738)1.94276280
105Hypoventilation (HP:0002791)1.93734231
106Abnormality of the phalanges of the hallux (HP:0010057)1.91166895
107Vertebral arch anomaly (HP:0008438)1.91136799
108Action tremor (HP:0002345)1.90091629
109Microglossia (HP:0000171)1.89556692
110Genital tract atresia (HP:0001827)1.88978082
111Generalized tonic-clonic seizures (HP:0002069)1.87190183
112Retinal dysplasia (HP:0007973)1.86970323
113Oligodactyly (hands) (HP:0001180)1.86309621
114Cortical dysplasia (HP:0002539)1.86069920
115Severe combined immunodeficiency (HP:0004430)1.85739852
116Mesomelia (HP:0003027)1.84588480
117Preaxial hand polydactyly (HP:0001177)1.84547112
118Impaired vibration sensation in the lower limbs (HP:0002166)1.84323461
119Morphological abnormality of the pyramidal tract (HP:0002062)1.84044040
120Short tibia (HP:0005736)1.83544056
121Nephronophthisis (HP:0000090)1.83483361
122Abnormal rod and cone electroretinograms (HP:0008323)1.82712585
123Incomplete penetrance (HP:0003829)1.82177523
124Overgrowth (HP:0001548)1.81968270
125Vaginal atresia (HP:0000148)1.81782382
126Curly hair (HP:0002212)1.81607070
127Bulbous nose (HP:0000414)1.81426221
128Vitreoretinal degeneration (HP:0000655)1.80912667
129Type II lissencephaly (HP:0007260)1.80896740
130Aplasia/Hypoplasia of the lens (HP:0008063)1.79035067
131Cellulitis (HP:0100658)1.78898536
132Aplasia/Hypoplasia of the tongue (HP:0010295)1.76619941
133Furrowed tongue (HP:0000221)1.75422907
134Toxemia of pregnancy (HP:0100603)1.75356407
135Hemiplegia (HP:0002301)1.75160543
136Abnormal number of incisors (HP:0011064)1.75039916
137Abnormality of permanent molar morphology (HP:0011071)1.74820106
138Abnormality of the dental root (HP:0006486)1.74820106
139Taurodontia (HP:0000679)1.74820106
140Decreased lacrimation (HP:0000633)1.74795368
141Tubulointerstitial fibrosis (HP:0005576)1.74585373
142Abnormality of the ischium (HP:0003174)1.74466602
143Supernumerary spleens (HP:0009799)1.74452714
144Synostosis involving the elbow (HP:0003938)1.73013557
145Humeroradial synostosis (HP:0003041)1.73013557
146Specific learning disability (HP:0001328)1.73001808
147Abnormality of salivation (HP:0100755)1.72725069
148Decreased circulating renin level (HP:0003351)1.72525840
149Abnormality of midbrain morphology (HP:0002418)1.72248010
150Molar tooth sign on MRI (HP:0002419)1.72248010
151Tubulointerstitial nephritis (HP:0001970)1.71871509
152Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.70869107
153Optic nerve hypoplasia (HP:0000609)1.70839924
154Cutaneous syndactyly (HP:0012725)1.70788519
155Polymicrogyria (HP:0002126)1.70663800
156Hypoplasia of the thymus (HP:0000778)1.70312619
157Abnormality of pain sensation (HP:0010832)1.70284733
158Impaired pain sensation (HP:0007328)1.70284733
159Chronic sinusitis (HP:0011109)1.69913845
160Pheochromocytoma (HP:0002666)1.69533799
161Morphological abnormality of the middle ear (HP:0008609)1.67685779
162Cystic liver disease (HP:0006706)1.67636040
163Abnormality of the diencephalon (HP:0010662)1.67508066
164Recurrent pneumonia (HP:0006532)1.67489967
165Anteriorly placed anus (HP:0001545)1.67411315
166Infantile muscular hypotonia (HP:0008947)1.66028716
167Accelerated skeletal maturation (HP:0005616)1.65735376
168Focal seizures (HP:0007359)1.65101510
169Pulmonary artery stenosis (HP:0004415)1.64698936
170Wormian bones (HP:0002645)1.64343019
171Blue irides (HP:0000635)1.63613230
172Recurrent corneal erosions (HP:0000495)1.63534673
173Aplasia/Hypoplasia of the tibia (HP:0005772)1.62149028
174Depressed nasal tip (HP:0000437)1.61486076
175Mask-like facies (HP:0000298)1.60473082
176Postaxial hand polydactyly (HP:0001162)1.59353115
177Constricted visual fields (HP:0001133)1.58726882

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K4.68726487
2MAPK134.24022308
3MAPKAPK34.08033555
4CASK3.70093544
5ERBB33.11146043
6SRPK12.77610911
7TIE12.67740108
8BMPR22.26539294
9TLK12.23494002
10MAP3K102.23301372
11TRPM71.92754624
12DYRK21.92037953
13BMPR1B1.87744657
14KIT1.83621182
15NLK1.75061504
16TNK21.73481753
17FGFR21.72785328
18MAP2K71.71550075
19DYRK31.70392846
20MAPKAPK51.69513822
21PAK31.64685242
22WNK31.59944711
23PNCK1.59523245
24BCR1.58924656
25MKNK21.58571351
26PINK11.54797026
27YES11.54047299
28SGK2231.43301481
29SGK4941.43301481
30CAMK1G1.35076908
31SIK11.30126121
32PLK41.28546996
33MARK21.28158447
34PRPF4B1.25662117
35DAPK21.25485179
36SGK21.22489114
37FER1.18458508
38UHMK11.18329670
39SIK31.17896266
40MAPK121.16072073
41TGFBR11.15822904
42MAP4K21.15311187
43MARK11.15188070
44RPS6KA21.11854501
45RPS6KB21.11675141
46TNIK1.09404933
47CSNK1A1L1.09038954
48PHKG21.08230462
49PHKG11.08230462
50AKT31.06374396
51GRK11.02208716
52MAP2K40.97652463
53EIF2AK20.97456155
54DDR20.96097854
55SIK20.96066030
56RPS6KB10.93976286
57NTRK10.93499820
58TAF10.92983321
59PLK20.92809017
60CDK50.91042268
61MINK10.90284988
62TYRO30.87612092
63MKNK10.86602336
64HIPK20.83627060
65NTRK20.83124552
66WNK40.82521703
67PRKG10.80663868
68EPHB20.79870197
69CAMK1D0.78213758
70CSNK1G10.77873231
71TGFBR20.77168241
72INSRR0.76869888
73MAP3K60.75801247
74FES0.74161479
75CDK90.74073991
76SGK30.72799516
77STK110.69641757
78FGFR30.69485443
79MAPK40.69411418
80DYRK1B0.68620740
81CSNK1G30.68290839
82MAPK110.67613375
83WNK10.67380987
84MAPK150.65203267
85STK240.64514210
86FRK0.63946305
87ADRBK20.63673724
88TRIM280.62291342
89PRKCE0.62085792
90GRK50.60915772
91CAMK2A0.60207208
92CAMK10.59862934
93ZAK0.59277264
94EPHA40.58914221
95NEK90.57284684
96KSR10.56005609
97CAMK40.55917132
98MAPKAPK20.53415812
99GRK60.53402724
100PRKACA0.52343584
101PRKCG0.51410496
102EPHA30.50826230
103PRKAA10.50546559
104PRKCQ0.49353673
105DYRK1A0.48839117
106AURKA0.48197942
107CSF1R0.47781905
108OXSR10.47733194
109IRAK40.46977173
110CAMK2B0.46836984
111STK390.45827347
112CSNK1G20.45159113
113PRKCZ0.45108572
114PRKD20.44529146
115MAPK70.42895702
116PRKCH0.42013962
117NUAK10.41709136
118ROCK20.41563507
119STK38L0.40605654
120VRK10.40214653
121PRKAA20.39871561
122CSNK1D0.39360207
123OBSCN0.39282870
124PRKACB0.39238752
125CAMK2D0.38260437
126ADRBK10.38030778
127ROCK10.38007041
128CDK30.37819556
129CDK80.37471384
130PRKD10.37185246
131SYK0.36173392
132DAPK30.34731006
133MAP3K40.34457049
134PKN10.34446426
135PDGFRA0.33126326
136RPS6KA40.33039922
137INSR0.32112279
138CAMKK20.32026203
139IRAK10.31254662
140ACVR1B0.31172050
141LIMK10.30534746
142MAP2K10.30394725
143DAPK10.30380111
144NTRK30.30049087
145RPS6KA30.29853269
146MST40.29377009

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047404.71196482
2Nicotine addiction_Homo sapiens_hsa050333.58926402
3Phototransduction_Homo sapiens_hsa047443.00507863
4Morphine addiction_Homo sapiens_hsa050322.03115690
5Cocaine addiction_Homo sapiens_hsa050302.01977063
6Basal cell carcinoma_Homo sapiens_hsa052171.84064197
7Cardiac muscle contraction_Homo sapiens_hsa042601.80168939
8Dorso-ventral axis formation_Homo sapiens_hsa043201.78712484
9Alcoholism_Homo sapiens_hsa050341.75147462
10Axon guidance_Homo sapiens_hsa043601.71538071
11Taste transduction_Homo sapiens_hsa047421.70190005
12Melanoma_Homo sapiens_hsa052181.60923169
13Hedgehog signaling pathway_Homo sapiens_hsa043401.60199850
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.54174538
15B cell receptor signaling pathway_Homo sapiens_hsa046621.52797524
16Non-homologous end-joining_Homo sapiens_hsa034501.51089727
17Cholinergic synapse_Homo sapiens_hsa047251.45035584
18Wnt signaling pathway_Homo sapiens_hsa043101.44261199
19Primary immunodeficiency_Homo sapiens_hsa053401.43209163
20Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.41910884
21Serotonergic synapse_Homo sapiens_hsa047261.41172066
22Systemic lupus erythematosus_Homo sapiens_hsa053221.40038580
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.39028595
24Nitrogen metabolism_Homo sapiens_hsa009101.36077932
25Glutamatergic synapse_Homo sapiens_hsa047241.35914090
26Type II diabetes mellitus_Homo sapiens_hsa049301.33786461
27Dopaminergic synapse_Homo sapiens_hsa047281.32566459
28Circadian entrainment_Homo sapiens_hsa047131.32189859
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.26146405
30Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.23599863
31Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.22689453
32Vascular smooth muscle contraction_Homo sapiens_hsa042701.20825102
33Ras signaling pathway_Homo sapiens_hsa040141.18647783
34Adherens junction_Homo sapiens_hsa045201.18430176
35Colorectal cancer_Homo sapiens_hsa052101.17616623
36Pathways in cancer_Homo sapiens_hsa052001.17083204
37Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.16859682
38SNARE interactions in vesicular transport_Homo sapiens_hsa041301.16790286
39Prostate cancer_Homo sapiens_hsa052151.13839491
40Glioma_Homo sapiens_hsa052141.13227381
41PI3K-Akt signaling pathway_Homo sapiens_hsa041511.12457894
42Parkinsons disease_Homo sapiens_hsa050121.12128525
43Transcriptional misregulation in cancer_Homo sapiens_hsa052021.10534226
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.06938152
45Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.05568591
46Notch signaling pathway_Homo sapiens_hsa043301.05121758
47Melanogenesis_Homo sapiens_hsa049161.03241644
48Synaptic vesicle cycle_Homo sapiens_hsa047211.02708983
49ErbB signaling pathway_Homo sapiens_hsa040121.01931909
50Chronic myeloid leukemia_Homo sapiens_hsa052201.00901399
51Endometrial cancer_Homo sapiens_hsa052131.00839092
52ECM-receptor interaction_Homo sapiens_hsa045121.00654640
53Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.98768291
54Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96859641
55Oxidative phosphorylation_Homo sapiens_hsa001900.94366574
56Thyroid cancer_Homo sapiens_hsa052160.94260357
57GABAergic synapse_Homo sapiens_hsa047270.93078009
58Neurotrophin signaling pathway_Homo sapiens_hsa047220.91294092
59Linoleic acid metabolism_Homo sapiens_hsa005910.91127813
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.91113791
61Salivary secretion_Homo sapiens_hsa049700.89747262
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89227042
63Chemokine signaling pathway_Homo sapiens_hsa040620.87622255
64Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.87461784
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.86446389
66Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.85818573
67Ether lipid metabolism_Homo sapiens_hsa005650.81267526
68Regulation of autophagy_Homo sapiens_hsa041400.81246225
69Acute myeloid leukemia_Homo sapiens_hsa052210.80750433
70Alzheimers disease_Homo sapiens_hsa050100.80377777
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79769668
72cAMP signaling pathway_Homo sapiens_hsa040240.79526374
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79389686
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.78596855
75Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.78422152
76Aldosterone synthesis and secretion_Homo sapiens_hsa049250.78163901
77Insulin secretion_Homo sapiens_hsa049110.76257502
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75482756
79Rap1 signaling pathway_Homo sapiens_hsa040150.75031630
80MAPK signaling pathway_Homo sapiens_hsa040100.74702098
81MicroRNAs in cancer_Homo sapiens_hsa052060.74241654
82TGF-beta signaling pathway_Homo sapiens_hsa043500.73800912
83Basal transcription factors_Homo sapiens_hsa030220.73563748
84Glycerolipid metabolism_Homo sapiens_hsa005610.72759602
85Viral myocarditis_Homo sapiens_hsa054160.72712288
86FoxO signaling pathway_Homo sapiens_hsa040680.71200525
87Fanconi anemia pathway_Homo sapiens_hsa034600.70782719
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.69995140
89Renin secretion_Homo sapiens_hsa049240.65223974
90Focal adhesion_Homo sapiens_hsa045100.64651196
91mRNA surveillance pathway_Homo sapiens_hsa030150.64365930
92Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63402815
93Long-term potentiation_Homo sapiens_hsa047200.63257504
94Asthma_Homo sapiens_hsa053100.62525882
95NF-kappa B signaling pathway_Homo sapiens_hsa040640.62259327
96Long-term depression_Homo sapiens_hsa047300.61694513
97Circadian rhythm_Homo sapiens_hsa047100.61689208
98ABC transporters_Homo sapiens_hsa020100.61666208
99Leukocyte transendothelial migration_Homo sapiens_hsa046700.61267157
100Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.60846751
101Ovarian steroidogenesis_Homo sapiens_hsa049130.60240249
102Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.58859870
103Dilated cardiomyopathy_Homo sapiens_hsa054140.58775291
104Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.58066805
105Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.57680194
106Spliceosome_Homo sapiens_hsa030400.57030287
107Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56583166
108PPAR signaling pathway_Homo sapiens_hsa033200.56399770
109cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54157018
110Hepatitis C_Homo sapiens_hsa051600.54055467
111GnRH signaling pathway_Homo sapiens_hsa049120.53409617
112Pancreatic cancer_Homo sapiens_hsa052120.52951371
113Insulin signaling pathway_Homo sapiens_hsa049100.51759304
114Butanoate metabolism_Homo sapiens_hsa006500.51598386
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51131360
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50897210
117Oxytocin signaling pathway_Homo sapiens_hsa049210.50396121
118Gap junction_Homo sapiens_hsa045400.50141494
119Sphingolipid metabolism_Homo sapiens_hsa006000.48690870
120Non-small cell lung cancer_Homo sapiens_hsa052230.47167488
121Viral carcinogenesis_Homo sapiens_hsa052030.46782337
122Intestinal immune network for IgA production_Homo sapiens_hsa046720.46550516
123Collecting duct acid secretion_Homo sapiens_hsa049660.45926038
124Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45460526
125Amphetamine addiction_Homo sapiens_hsa050310.44328508
126Gastric acid secretion_Homo sapiens_hsa049710.43379362
127Hippo signaling pathway_Homo sapiens_hsa043900.43372565
128Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.43275966
129Huntingtons disease_Homo sapiens_hsa050160.43181380
130Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.42730289
131Estrogen signaling pathway_Homo sapiens_hsa049150.42531574
132Protein digestion and absorption_Homo sapiens_hsa049740.42484306
133Tryptophan metabolism_Homo sapiens_hsa003800.41988864
134Base excision repair_Homo sapiens_hsa034100.41972513
135Renin-angiotensin system_Homo sapiens_hsa046140.41954954
136Small cell lung cancer_Homo sapiens_hsa052220.41482321
137Prolactin signaling pathway_Homo sapiens_hsa049170.41227193
138Calcium signaling pathway_Homo sapiens_hsa040200.40762398
139Tight junction_Homo sapiens_hsa045300.40057082
140Protein export_Homo sapiens_hsa030600.40030811
141AMPK signaling pathway_Homo sapiens_hsa041520.37626394
142Fatty acid biosynthesis_Homo sapiens_hsa000610.37503980
143Phagosome_Homo sapiens_hsa041450.37133388

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