EBF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the COE (Collier/Olf/EBF) family of non-basic, helix-loop-helix transcription factors that have a well conserved DNA binding domain. The COE family proteins play an important role in variety of developmental processes. Studies in mouse suggest that this gene may be involved in the differentiation of osteoblasts. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sensory perception of chemical stimulus (GO:0007606)7.64693799
2olfactory bulb development (GO:0021772)7.43323023
3protein insertion into membrane (GO:0051205)7.40326049
4negative regulation of transcription regulatory region DNA binding (GO:2000678)6.41586344
5regulation of cilium movement (GO:0003352)6.30629206
6protein localization to cilium (GO:0061512)5.79624535
7adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)5.65773622
8snRNA transcription (GO:0009301)5.42230310
9auditory receptor cell differentiation (GO:0042491)5.34124567
10dosage compensation (GO:0007549)5.20848352
11protein polyglutamylation (GO:0018095)5.18612644
12ganglion development (GO:0061548)4.93740337
13sequestering of actin monomers (GO:0042989)4.93596961
14atrial cardiac muscle cell action potential (GO:0086014)4.89637223
15ovulation cycle (GO:0042698)4.82648774
16intraciliary transport (GO:0042073)4.67304112
17axoneme assembly (GO:0035082)4.51730662
18behavioral response to nicotine (GO:0035095)4.45389381
19negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 4.27989633
20cell migration in hindbrain (GO:0021535)4.27414064
21phosphorelay signal transduction system (GO:0000160)4.19350314
22metanephric mesenchyme development (GO:0072075)4.15622975
23positive regulation of oligodendrocyte differentiation (GO:0048714)4.09664970
24cilium movement (GO:0003341)4.07567687
25eyelid development in camera-type eye (GO:0061029)4.06059423
26cilium morphogenesis (GO:0060271)3.98351724
27mating behavior (GO:0007617)3.97992932
28axon extension (GO:0048675)3.89084977
29negative regulation of microtubule polymerization (GO:0031115)3.88327997
30presynaptic membrane organization (GO:0097090)3.87508741
31female mating behavior (GO:0060180)3.86910974
32epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.85678429
33pyrimidine nucleobase catabolic process (GO:0006208)3.78709172
34regulation of heart rate by cardiac conduction (GO:0086091)3.75475744
35microtubule severing (GO:0051013)3.74263597
36regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 3.73886989
37behavioral response to ethanol (GO:0048149)3.73580893
38natural killer cell mediated cytotoxicity (GO:0042267)3.72550799
39natural killer cell mediated immunity (GO:0002228)3.72550799
40regulation of female receptivity (GO:0045924)3.69304806
41negative regulation of astrocyte differentiation (GO:0048712)3.67387746
42peripheral nervous system neuron development (GO:0048935)3.66835263
43retinal ganglion cell axon guidance (GO:0031290)3.65788887
44microtubule bundle formation (GO:0001578)3.65177054
45axonal fasciculation (GO:0007413)3.64483943
46detection of calcium ion (GO:0005513)3.64241669
47behavioral response to cocaine (GO:0048148)3.62745697
48neuronal action potential propagation (GO:0019227)3.61456852
49central nervous system projection neuron axonogenesis (GO:0021952)3.61020414
50cellular response to prostaglandin stimulus (GO:0071379)3.60647487
51neuron projection extension involved in neuron projection guidance (GO:1902284)3.58877100
52axon extension involved in axon guidance (GO:0048846)3.58877100
53kidney mesenchyme development (GO:0072074)3.57241858
54positive regulation of gastrulation (GO:2000543)3.56962740
55calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.53930747
56regulation of microtubule-based movement (GO:0060632)3.50995422
57synaptic vesicle docking involved in exocytosis (GO:0016081)3.50225284
58tachykinin receptor signaling pathway (GO:0007217)3.49207327
59regulation of alternative mRNA splicing, via spliceosome (GO:0000381)3.49171759
60facial nerve structural organization (GO:0021612)3.47995185
61left/right axis specification (GO:0070986)3.46871192
62negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)3.45599409
63calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.43022592
64epithelial cilium movement (GO:0003351)3.42833421
65calcium-mediated signaling using intracellular calcium source (GO:0035584)3.41637675
66membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.40912924
67substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.40080781
68substrate-independent telencephalic tangential migration (GO:0021826)3.40080781
69neuronal ion channel clustering (GO:0045161)3.38394749
70hippocampus development (GO:0021766)3.38026718
71regulation of axon extension involved in axon guidance (GO:0048841)3.37960244
72nucleosome disassembly (GO:0006337)3.36609940
73protein-DNA complex disassembly (GO:0032986)3.36609940
74negative regulation of cytosolic calcium ion concentration (GO:0051481)3.34763932
75negative regulation of axon extension involved in axon guidance (GO:0048843)3.33991293
76establishment of mitochondrion localization (GO:0051654)3.30485090
77endocrine hormone secretion (GO:0060986)3.29771091
78regulation of axon guidance (GO:1902667)3.29291785
79cellular response to glucagon stimulus (GO:0071377)3.27707584
80neuron cell-cell adhesion (GO:0007158)3.25278908
81neuron projection extension (GO:1990138)3.23581023
82embryonic body morphogenesis (GO:0010172)3.23562923
83regulation of transcription regulatory region DNA binding (GO:2000677)3.19901126
84keratinocyte development (GO:0003334)3.19204186
85cardiac conduction (GO:0061337)3.18465921
86inner ear receptor cell differentiation (GO:0060113)3.17459879
87sensory perception of taste (GO:0050909)3.16836472
88dendritic spine morphogenesis (GO:0060997)3.16797364
89glial cell proliferation (GO:0014009)3.16477251
90cilium assembly (GO:0042384)3.15513472
91hair cell differentiation (GO:0035315)3.13386928
92modulation by virus of host process (GO:0019054)3.12956919
93neuron fate specification (GO:0048665)3.12591535
94axonemal dynein complex assembly (GO:0070286)3.10006098
95neuromuscular synaptic transmission (GO:0007274)3.07123244
96cornea development in camera-type eye (GO:0061303)3.06928885
97centriole replication (GO:0007099)3.06913954
98adult walking behavior (GO:0007628)3.03294471
99regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)3.03276691
100regulation of oligodendrocyte differentiation (GO:0048713)3.01069150
101positive regulation of growth hormone secretion (GO:0060124)2.99507135
102paraxial mesoderm development (GO:0048339)2.99339610
103synapse assembly (GO:0007416)2.98942196
104neuron remodeling (GO:0016322)2.98854510
105dendrite development (GO:0016358)2.97842782
106negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.97694819
107cilium organization (GO:0044782)2.96156864
108activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.95873479
109presynaptic membrane assembly (GO:0097105)2.95301195
110somite development (GO:0061053)2.94468995
111melanosome transport (GO:0032402)2.94431510
112spinal cord development (GO:0021510)2.93798894
113regulation of cell communication by electrical coupling (GO:0010649)2.93472069
114body morphogenesis (GO:0010171)2.92938298
115mitochondrion transport along microtubule (GO:0047497)2.92632168
116establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.92632168
117segment specification (GO:0007379)2.92262688
118cranial nerve morphogenesis (GO:0021602)2.89909292
119limb bud formation (GO:0060174)2.89339860
120startle response (GO:0001964)2.88339092
121negative regulation of catenin import into nucleus (GO:0035414)2.88158142
122nonmotile primary cilium assembly (GO:0035058)2.87844868
123neuron recognition (GO:0008038)2.86788275
124urinary tract smooth muscle contraction (GO:0014848)2.83984804
125limb development (GO:0060173)2.83607125
126appendage development (GO:0048736)2.83607125
127gamma-aminobutyric acid transport (GO:0015812)2.83011088
128positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.81466809
129neuronal action potential (GO:0019228)2.81009786
130negative chemotaxis (GO:0050919)2.80693839
131detection of light stimulus involved in visual perception (GO:0050908)2.80474628
132detection of light stimulus involved in sensory perception (GO:0050962)2.80474628
133positive regulation of DNA-templated transcription, elongation (GO:0032786)2.79785813
134negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage (GO:1902230)2.79447699
135photoreceptor cell maintenance (GO:0045494)2.79340129
136nucleobase catabolic process (GO:0046113)2.79173228
137pigment granule transport (GO:0051904)2.78535963
138regulation of growth hormone secretion (GO:0060123)2.78483480
139innate immune response in mucosa (GO:0002227)2.78298657
140ionotropic glutamate receptor signaling pathway (GO:0035235)2.77942522
141negative regulation of axon guidance (GO:1902668)2.77027211
142brain morphogenesis (GO:0048854)2.76030019
143regulation of synapse structural plasticity (GO:0051823)2.75967292
144forebrain neuron differentiation (GO:0021879)2.75267392
145neuron migration (GO:0001764)2.74813393
146dendrite morphogenesis (GO:0048813)2.73874913
147chemical homeostasis within a tissue (GO:0048875)2.73611841
148establishment of melanosome localization (GO:0032401)2.72750593
149central nervous system neuron axonogenesis (GO:0021955)2.72507370
150regulation of hippo signaling (GO:0035330)2.72158315
151response to prostaglandin E (GO:0034695)2.72085655
152protein localization to synapse (GO:0035418)2.71240708
153regulation of female gonad development (GO:2000194)2.70769358
154postsynaptic membrane organization (GO:0001941)2.70039833
155peristalsis (GO:0030432)2.69800114
156transmission of nerve impulse (GO:0019226)2.69610892
157ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.68523549
158camera-type eye morphogenesis (GO:0048593)2.63864147
159positive regulation of dendritic spine morphogenesis (GO:0061003)2.63591515
160positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.62481505
161auditory behavior (GO:0031223)2.60507315
162neurofilament cytoskeleton organization (GO:0060052)2.60339595
163generation of neurons (GO:0048699)2.59458162
164synaptic transmission, glutamatergic (GO:0035249)2.57925131
165regulation of membrane repolarization (GO:0060306)2.56881690
166short-term memory (GO:0007614)2.56651668
167regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.52582919
168regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.50306690
169striatum development (GO:0021756)2.49115553
170neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.44672193
171regulation of synapse assembly (GO:0051963)2.41929694
172neuron maturation (GO:0042551)2.41465660
173negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.40906108
174adult locomotory behavior (GO:0008344)2.40607769
175suckling behavior (GO:0001967)2.38775602
176proximal/distal pattern formation (GO:0009954)2.38309106
177membrane depolarization during action potential (GO:0086010)2.37902884
178sensory perception of smell (GO:0007608)11.7999287

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse4.31499517
2* EZH2_22144423_ChIP-Seq_EOC_Human3.26827349
3TAF15_26573619_Chip-Seq_HEK293_Human3.20363488
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.79605748
5* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.77041220
6GBX2_23144817_ChIP-Seq_PC3_Human2.75640985
7* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.68561315
8* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.68561315
9TP63_19390658_ChIP-ChIP_HaCaT_Human2.50472112
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.45273034
11* EED_16625203_ChIP-ChIP_MESCs_Mouse2.43710521
12* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.25369550
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.18756437
14AHR_22903824_ChIP-Seq_MCF-7_Human2.17971719
15* EZH2_27304074_Chip-Seq_ESCs_Mouse2.12243977
16* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.10289577
17PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.09773533
18* RNF2_27304074_Chip-Seq_ESCs_Mouse2.08779342
19SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.02793201
20* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.98470224
21ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.96849907
22* CBX2_27304074_Chip-Seq_ESCs_Mouse1.95484114
23* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.95082630
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.90550315
25DROSHA_22980978_ChIP-Seq_HELA_Human1.90118125
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.89305786
27* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.86151547
28* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.83251831
29* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.83040028
30* RING1B_27294783_Chip-Seq_ESCs_Mouse1.82396055
31* EZH2_27294783_Chip-Seq_ESCs_Mouse1.79699560
32* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.78356007
33VDR_22108803_ChIP-Seq_LS180_Human1.77761373
34SMAD_19615063_ChIP-ChIP_OVARY_Human1.75997275
35IGF1R_20145208_ChIP-Seq_DFB_Human1.72153286
36IKZF1_21737484_ChIP-ChIP_HCT116_Human1.68600111
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.64345021
38POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.63127713
39TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63127713
40CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63019226
41ZNF274_21170338_ChIP-Seq_K562_Hela1.62732231
42* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.62675520
43* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.59905884
44CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.59250368
45WT1_19549856_ChIP-ChIP_CCG9911_Human1.58057918
46FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.57795706
47ARNT_22903824_ChIP-Seq_MCF-7_Human1.54096200
48* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49679498
49* RNF2_27304074_Chip-Seq_NSC_Mouse1.49093849
50* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.48913524
51RUNX1_26923725_Chip-Seq_HPCs_Mouse1.48369738
52ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.47604720
53FUS_26573619_Chip-Seq_HEK293_Human1.46899616
54* RING1B_27294783_Chip-Seq_NPCs_Mouse1.44011010
55* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.43809368
56ZNF217_24962896_ChIP-Seq_MCF-7_Human1.43080917
57HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.40142072
58* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.38878001
59SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.38664332
60MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.34710706
61CDX2_19796622_ChIP-Seq_MESCs_Mouse1.34605642
62KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.29987299
63* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.28729234
64GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27699808
65GATA1_26923725_Chip-Seq_HPCs_Mouse1.26908608
66KDM2B_26808549_Chip-Seq_K562_Human1.25818402
67* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23821033
68TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23356805
69TP53_18474530_ChIP-ChIP_U2OS_Human1.23139376
70REST_21632747_ChIP-Seq_MESCs_Mouse1.21282118
71TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.19942839
72* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19032259
73EWS_26573619_Chip-Seq_HEK293_Human1.18285846
74HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.18041959
75PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.16713003
76ZNF263_19887448_ChIP-Seq_K562_Human1.16162263
77UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15316545
78SOX2_18555785_ChIP-Seq_MESCs_Mouse1.15316200
79SMAD3_21741376_ChIP-Seq_EPCs_Human1.15000781
80AR_25329375_ChIP-Seq_VCAP_Human1.13868204
81* P300_19829295_ChIP-Seq_ESCs_Human1.13832541
82STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.13461183
83TDRD3_21172665_ChIP-Seq_MCF-7_Human1.11437523
84STAT3_23295773_ChIP-Seq_U87_Human1.10865553
85WDR5_24793694_ChIP-Seq_LNCAP_Human1.10161816
86ZFP57_27257070_Chip-Seq_ESCs_Mouse1.09776216
87* TP53_20018659_ChIP-ChIP_R1E_Mouse1.09355663
88LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09317678
89ELK4_26923725_Chip-Seq_MESODERM_Mouse1.06061070
90SOX2_21211035_ChIP-Seq_LN229_Gbm1.05278824
91SMAD4_21799915_ChIP-Seq_A2780_Human1.05198933
92ISL1_27105846_Chip-Seq_CPCs_Mouse1.04826887
93PIAS1_25552417_ChIP-Seq_VCAP_Human1.04824818
94POU3F2_20337985_ChIP-ChIP_501MEL_Human1.04774745
95TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04653201
96LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03688023
97MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.03112435
98* RUNX2_22187159_ChIP-Seq_PCA_Human1.03073294
99SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.02613654
100TCF4_23295773_ChIP-Seq_U87_Human1.01925666
101TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99882228
102BCAT_22108803_ChIP-Seq_LS180_Human0.99460070
103POU5F1_16153702_ChIP-ChIP_HESCs_Human0.99229371
104CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.99226617
105KDM2B_26808549_Chip-Seq_REH_Human0.98887180
106* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.98692417
107NANOG_18555785_Chip-Seq_ESCs_Mouse0.98227167
108IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98126672
109CBP_20019798_ChIP-Seq_JUKART_Human0.98126672
110RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.97760063
111NFIB_24661679_ChIP-Seq_LUNG_Mouse0.97557572
112RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97053005
113EP300_21415370_ChIP-Seq_HL-1_Mouse0.96599944
114PCGF2_27294783_Chip-Seq_NPCs_Mouse0.95405301
115* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.95339302
116SOX9_26525672_Chip-Seq_HEART_Mouse0.95262750
117* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.95034363
118ZFP281_27345836_Chip-Seq_ESCs_Mouse0.94593575
119OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94487891
120MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.93722698
121ER_23166858_ChIP-Seq_MCF-7_Human0.93024139
122PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.93012285
123* AR_19668381_ChIP-Seq_PC3_Human0.93011342
124AR_21572438_ChIP-Seq_LNCaP_Human0.92315409
125FLI1_27457419_Chip-Seq_LIVER_Mouse0.91927763
126SUZ12_27294783_Chip-Seq_NPCs_Mouse0.91760177
127ZFP281_18757296_ChIP-ChIP_E14_Mouse0.91472295
128STAT3_18555785_ChIP-Seq_MESCs_Mouse0.90689112
129VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.89689439
130MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88592981
131CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.87327515
132SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.86565149
133* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.86494456
134ESR1_20079471_ChIP-ChIP_T-47D_Human0.86350446
135SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86163067
136EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.85767505
137REST_18959480_ChIP-ChIP_MESCs_Mouse0.85341739

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001984_abnormal_olfaction8.41987951
2* MP0008789_abnormal_olfactory_epithelium4.84518042
3* MP0005499_abnormal_olfactory_system4.10626229
4* MP0005394_taste/olfaction_phenotype4.10626229
5MP0003787_abnormal_imprinting3.69238990
6MP0000372_irregular_coat_pigmentation3.21324185
7MP0002102_abnormal_ear_morphology2.90603505
8MP0003878_abnormal_ear_physiology2.84127247
9MP0005377_hearing/vestibular/ear_phenot2.84127247
10MP0006276_abnormal_autonomic_nervous2.82277680
11MP0002653_abnormal_ependyma_morphology2.72865640
12MP0000778_abnormal_nervous_system2.43286730
13MP0001485_abnormal_pinna_reflex2.43275820
14MP0004859_abnormal_synaptic_plasticity2.35677849
15MP0002938_white_spotting2.24802547
16MP0002822_catalepsy2.18199557
17* MP0002184_abnormal_innervation2.16976185
18MP0001529_abnormal_vocalization2.07487322
19MP0001293_anophthalmia2.01080596
20MP0000566_synostosis1.95913134
21MP0004133_heterotaxia1.92698930
22MP0004145_abnormal_muscle_electrophysio1.81351454
23MP0010030_abnormal_orbit_morphology1.80806351
24MP0002735_abnormal_chemical_nociception1.80666144
25MP0004270_analgesia1.80272282
26MP0002638_abnormal_pupillary_reflex1.76369705
27MP0002909_abnormal_adrenal_gland1.74832750
28MP0000569_abnormal_digit_pigmentation1.71463938
29MP0008877_abnormal_DNA_methylation1.70769499
30MP0002751_abnormal_autonomic_nervous1.69579818
31* MP0002752_abnormal_somatic_nervous1.68042854
32MP0005187_abnormal_penis_morphology1.67188217
33MP0008438_abnormal_cutaneous_collagen1.61701262
34MP0005503_abnormal_tendon_morphology1.56450591
35MP0003122_maternal_imprinting1.55811619
36MP0005275_abnormal_skin_tensile1.52050124
37MP0003861_abnormal_nervous_system1.50036886
38* MP0002233_abnormal_nose_morphology1.47330221
39MP0001968_abnormal_touch/_nociception1.47273296
40MP0009745_abnormal_behavioral_response1.43382793
41MP0005174_abnormal_tail_pigmentation1.43048099
42MP0000026_abnormal_inner_ear1.40757161
43MP0002734_abnormal_mechanical_nocicepti1.40681425
44MP0002163_abnormal_gland_morphology1.37465231
45MP0006292_abnormal_olfactory_placode1.35368265
46* MP0002882_abnormal_neuron_morphology1.33922159
47MP0003315_abnormal_perineum_morphology1.33488551
48MP0002572_abnormal_emotion/affect_behav1.33034022
49MP0004885_abnormal_endolymph1.31384961
50MP0000049_abnormal_middle_ear1.30811516
51* MP0002557_abnormal_social/conspecific_i1.28264240
52MP0004134_abnormal_chest_morphology1.25964015
53MP0005367_renal/urinary_system_phenotyp1.22253889
54MP0000516_abnormal_urinary_system1.22253889
55MP0004742_abnormal_vestibular_system1.21835908
56MP0003121_genomic_imprinting1.21764691
57MP0000534_abnormal_ureter_morphology1.19265075
58MP0005623_abnormal_meninges_morphology1.17946650
59* MP0002152_abnormal_brain_morphology1.17355840
60MP0001970_abnormal_pain_threshold1.17285448
61MP0001286_abnormal_eye_development1.17176773
62MP0003119_abnormal_digestive_system1.15974345
63MP0003137_abnormal_impulse_conducting1.15037340
64MP0009250_abnormal_appendicular_skeleto1.14807249
65MP0003646_muscle_fatigue1.13993759
66MP0001299_abnormal_eye_distance/1.10717007
67MP0005386_behavior/neurological_phenoty1.08761245
68MP0004924_abnormal_behavior1.08761245
69MP0001486_abnormal_startle_reflex1.08387327
70MP0009046_muscle_twitch1.07364956
71MP0006072_abnormal_retinal_apoptosis1.05603228
72MP0002092_abnormal_eye_morphology1.04879310
73MP0008995_early_reproductive_senescence1.03358942
74MP0002249_abnormal_larynx_morphology1.02734031
75MP0001879_abnormal_lymphatic_vessel1.01121212
76MP0003385_abnormal_body_wall0.99987854
77MP0002932_abnormal_joint_morphology0.99491006
78MP0004142_abnormal_muscle_tone0.99235161
79MP0001963_abnormal_hearing_physiology0.98309161
80MP0002064_seizures0.97237116
81MP0000751_myopathy0.96767372
82* MP0005645_abnormal_hypothalamus_physiol0.96338897
83MP0004858_abnormal_nervous_system0.93957054
84MP0000631_abnormal_neuroendocrine_gland0.93844951
85MP0004811_abnormal_neuron_physiology0.93060745
86MP0002116_abnormal_craniofacial_bone0.92815628
87MP0002234_abnormal_pharynx_morphology0.91770137
88MP0005257_abnormal_intraocular_pressure0.91050580
89MP0001188_hyperpigmentation0.90182777
90MP0005423_abnormal_somatic_nervous0.89574473
91MP0002081_perinatal_lethality0.87902122
92MP0005670_abnormal_white_adipose0.87644702
93MP0002896_abnormal_bone_mineralization0.87132163
94MP0001905_abnormal_dopamine_level0.86967214
95* MP0002066_abnormal_motor_capabilities/c0.85858309
96MP0010368_abnormal_lymphatic_system0.85790504
97MP0005171_absent_coat_pigmentation0.85736358
98MP0002733_abnormal_thermal_nociception0.84804740
99MP0005248_abnormal_Harderian_gland0.83193242
100MP0005508_abnormal_skeleton_morphology0.81716741
101MP0005253_abnormal_eye_physiology0.81695489
102MP0003942_abnormal_urinary_system0.81065703
103MP0010386_abnormal_urinary_bladder0.79868763
104MP0000733_abnormal_muscle_development0.79285366
105MP0009703_decreased_birth_body0.78923329
106MP0004130_abnormal_muscle_cell0.78653582
107MP0004084_abnormal_cardiac_muscle0.78255901
108MP0003755_abnormal_palate_morphology0.77654659
109MP0002132_abnormal_respiratory_system0.77603955
110MP0005195_abnormal_posterior_eye0.77516575
111MP0002063_abnormal_learning/memory/cond0.74397305
112MP0002067_abnormal_sensory_capabilities0.74157913
113MP0003937_abnormal_limbs/digits/tail_de0.73793618
114MP0003635_abnormal_synaptic_transmissio0.73576757
115MP0000427_abnormal_hair_cycle0.73452360
116MP0002877_abnormal_melanocyte_morpholog0.73280219
117MP0004085_abnormal_heartbeat0.71426000
118MP0003806_abnormal_nucleotide_metabolis0.71261330
119* MP0002160_abnormal_reproductive_system0.69922281
120MP0003880_abnormal_central_pattern0.68733181
121MP0005551_abnormal_eye_electrophysiolog0.68546183
122MP0003935_abnormal_craniofacial_develop0.66009375
123MP0001502_abnormal_circadian_rhythm0.65795727
124MP0000955_abnormal_spinal_cord0.64572602
125MP0004215_abnormal_myocardial_fiber0.62662460
126MP0008058_abnormal_DNA_repair0.62201717
127MP0000647_abnormal_sebaceous_gland0.60945330
128MP0003567_abnormal_fetal_cardiomyocyte0.60786121
129MP0005646_abnormal_pituitary_gland0.60311426
130MP0005391_vision/eye_phenotype0.58413926
131MP0001324_abnormal_eye_pigmentation0.56237339
132MP0003938_abnormal_ear_development0.56056178
133MP0000538_abnormal_urinary_bladder0.55487458
134MP0002127_abnormal_cardiovascular_syste0.54900019
135MP0000432_abnormal_head_morphology0.54545626
136MP0002928_abnormal_bile_duct0.54417398
137MP0002111_abnormal_tail_morphology0.54081696
138MP0003890_abnormal_embryonic-extraembry0.53495262
139MP0003948_abnormal_gas_homeostasis0.52946896
140MP0002108_abnormal_muscle_morphology0.52941274
141* MP0002272_abnormal_nervous_system0.51491496
142MP0005084_abnormal_gallbladder_morpholo0.51136796

Predicted human phenotypes

RankGene SetZ-score
1Anosmia (HP:0000458)5.78512610
2Hypothermia (HP:0002045)5.42432922
3Pelvic girdle muscle weakness (HP:0003749)5.02382860
4Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.77214670
5Abnormal respiratory motile cilium physiology (HP:0012261)4.67173350
6Abnormal ciliary motility (HP:0012262)4.53516061
7Calcaneovalgus deformity (HP:0001848)4.51891018
8Abnormality of the musculature of the pelvis (HP:0001469)4.51539937
9Abnormality of the hip-girdle musculature (HP:0001445)4.51539937
10Abnormal respiratory epithelium morphology (HP:0012253)4.12221311
11Abnormal respiratory motile cilium morphology (HP:0005938)4.12221311
12Deformed tarsal bones (HP:0008119)4.00459994
13Abnormality of macular pigmentation (HP:0008002)3.83923479
14Palpitations (HP:0001962)3.71550709
15Medial flaring of the eyebrow (HP:0010747)3.63956483
16Gait imbalance (HP:0002141)3.61368239
17Rhinitis (HP:0012384)3.59751745
18Abnormality of midbrain morphology (HP:0002418)3.54422721
19Molar tooth sign on MRI (HP:0002419)3.54422721
20Febrile seizures (HP:0002373)3.53065370
21Retinal dysplasia (HP:0007973)3.52626628
22Abnormality of the intervertebral disk (HP:0005108)3.51666202
23Congenital primary aphakia (HP:0007707)3.47191122
24Palpebral edema (HP:0100540)3.25218974
25Nephrogenic diabetes insipidus (HP:0009806)3.20240863
26Pancreatic fibrosis (HP:0100732)3.14565016
27Atonic seizures (HP:0010819)3.10141728
28Limb dystonia (HP:0002451)3.06836456
29Morphological abnormality of the middle ear (HP:0008609)3.06189316
30Insomnia (HP:0100785)3.02471695
31Renovascular hypertension (HP:0100817)2.88956664
32Hypoplasia of the brainstem (HP:0002365)2.83966666
33Aplasia/Hypoplasia of the brainstem (HP:0007362)2.83966666
34Peritonitis (HP:0002586)2.81246381
35Osteomalacia (HP:0002749)2.79757216
36Wrist flexion contracture (HP:0001239)2.79712037
37Bifid tongue (HP:0010297)2.77340517
38Asymmetry of the thorax (HP:0001555)2.75639932
39Erectile abnormalities (HP:0100639)2.72172067
40Infantile muscular hypotonia (HP:0008947)2.69959670
41Vaginal atresia (HP:0000148)2.68849873
42Abnormality of dentin (HP:0010299)2.67303647
43Genital tract atresia (HP:0001827)2.65400453
44Postaxial hand polydactyly (HP:0001162)2.64470812
45Nephronophthisis (HP:0000090)2.62118961
46Agitation (HP:0000713)2.60293081
47Poor coordination (HP:0002370)2.59030193
48Bradycardia (HP:0001662)2.57011021
49Aplasia/Hypoplasia of the lens (HP:0008063)2.52675733
50Xerostomia (HP:0000217)2.51795708
51Abnormality of the calcaneus (HP:0008364)2.49703294
52Chronic hepatic failure (HP:0100626)2.48832546
53True hermaphroditism (HP:0010459)2.46603316
54Drooling (HP:0002307)2.45481702
55Dynein arm defect of respiratory motile cilia (HP:0012255)2.42788389
56Absent/shortened dynein arms (HP:0200106)2.42788389
57Mask-like facies (HP:0000298)2.42199927
58Myokymia (HP:0002411)2.41280046
59Decreased testicular size (HP:0008734)2.39656067
60Abnormality of the lower motor neuron (HP:0002366)2.38987683
61Focal motor seizures (HP:0011153)2.37814734
62Limb-girdle muscle weakness (HP:0003325)2.34734595
63Occipital encephalocele (HP:0002085)2.33915386
64Ulnar claw (HP:0001178)2.31819369
65Soft skin (HP:0000977)2.31323716
66Hepatoblastoma (HP:0002884)2.31166229
67Anterior segment dysgenesis (HP:0007700)2.30771755
68Broad-based gait (HP:0002136)2.24655317
69Curly hair (HP:0002212)2.24191740
70Genu recurvatum (HP:0002816)2.23682148
71Atrophic scars (HP:0001075)2.19633423
72Bony spicule pigmentary retinopathy (HP:0007737)2.18514310
73Progressive cerebellar ataxia (HP:0002073)2.17256721
74Excessive salivation (HP:0003781)2.16193831
75Rib fusion (HP:0000902)2.14848246
76Increased corneal curvature (HP:0100692)2.12785496
77Keratoconus (HP:0000563)2.12785496
78Abnormality of the renal medulla (HP:0100957)2.12572692
79Intellectual disability, moderate (HP:0002342)2.11672160
80Elfin facies (HP:0004428)2.11546031
81Pachygyria (HP:0001302)2.11160688
82Foot dorsiflexor weakness (HP:0009027)2.10542208
83Primary atrial arrhythmia (HP:0001692)2.10069260
84Breast aplasia (HP:0100783)2.09700520
85Prolonged QT interval (HP:0001657)2.08719461
86Facial edema (HP:0000282)2.08207365
87Periorbital edema (HP:0100539)2.07428446
88Abnormality of the diencephalon (HP:0010662)2.07277954
89Flat cornea (HP:0007720)2.04569066
90Aplasia/Hypoplasia of the patella (HP:0006498)2.04391103
91Exotropia (HP:0000577)2.03928920
92Midline defect of the nose (HP:0004122)2.01117853
93Fetal akinesia sequence (HP:0001989)2.00976908
94Polyphagia (HP:0002591)2.00175412
95Abnormality of the foot musculature (HP:0001436)1.99812510
96Shawl scrotum (HP:0000049)1.98718374
97Supraventricular tachycardia (HP:0004755)1.96685142
98Vertebral arch anomaly (HP:0008438)1.96432053
99Cutaneous finger syndactyly (HP:0010554)1.96159626
100Rimmed vacuoles (HP:0003805)1.95822203
101Absent phalangeal crease (HP:0006109)1.94583020
102Syncope (HP:0001279)1.94168943
103Spina bifida occulta (HP:0003298)1.93677025
104Premature rupture of membranes (HP:0001788)1.93357409
105Type 1 muscle fiber predominance (HP:0003803)1.93078332
106Facial cleft (HP:0002006)1.92293151
107Anencephaly (HP:0002323)1.92285328
108Sudden death (HP:0001699)1.92251665
109Supraventricular arrhythmia (HP:0005115)1.92094436
110Bladder diverticulum (HP:0000015)1.89387228
111Supernumerary spleens (HP:0009799)1.89131305
112Slow-growing hair (HP:0002217)1.88984233
113Abnormality of hair growth rate (HP:0011363)1.88984233
114Wormian bones (HP:0002645)1.88877306
115Cortical dysplasia (HP:0002539)1.88164273
116Distal arthrogryposis (HP:0005684)1.87324872
117Pancreatic cysts (HP:0001737)1.87042345
118Postaxial foot polydactyly (HP:0001830)1.86622506
119Aplasia/Hypoplasia of the breasts (HP:0010311)1.86545786
120Vitreoretinal degeneration (HP:0000655)1.86431652
121Lissencephaly (HP:0001339)1.86187823
122Sex reversal (HP:0012245)1.85564359
123Abnormal sex determination (HP:0012244)1.85564359
124Steppage gait (HP:0003376)1.83822218
125Renal duplication (HP:0000075)1.83739398
126Focal seizures (HP:0007359)1.82980805
127Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.82422986
128Concave nail (HP:0001598)1.82297057
129Patellar aplasia (HP:0006443)1.81861097
130Bell-shaped thorax (HP:0001591)1.81300581
131Abnormality of the ischium (HP:0003174)1.80677153
132Myotonia (HP:0002486)1.80557253
133Cutaneous syndactyly (HP:0012725)1.79887338
134Chronic bronchitis (HP:0004469)1.79831909
135Median cleft lip (HP:0000161)1.79789911
136Micropenis (HP:0000054)1.79654104
137Short 4th metacarpal (HP:0010044)1.79388007
138Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.79388007
139Congenital hepatic fibrosis (HP:0002612)1.79271034
140Abnormal EKG (HP:0003115)1.78632761
141Pendular nystagmus (HP:0012043)1.77640654
142Impaired vibration sensation in the lower limbs (HP:0002166)1.76909295
143Cystic liver disease (HP:0006706)1.76193112
144Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.75801308
145Preaxial hand polydactyly (HP:0001177)1.75601395
146Dysphonia (HP:0001618)1.75510851
147Neonatal short-limb short stature (HP:0008921)1.75131133
148Mitral valve prolapse (HP:0001634)1.74935076
149Chronic sinusitis (HP:0011109)1.74914420
150Specific learning disability (HP:0001328)1.74899506
151Polycystic ovaries (HP:0000147)1.74380324
152Atrial fibrillation (HP:0005110)1.73205800
153Aplasia/Hypoplasia of the sternum (HP:0006714)1.73121435
154Wide anterior fontanel (HP:0000260)1.72834311
155Chorioretinal atrophy (HP:0000533)1.72556333
156Amblyopia (HP:0000646)1.72097802
157Genetic anticipation (HP:0003743)1.71963655
158High anterior hairline (HP:0009890)1.71408014
159Mild short stature (HP:0003502)1.71333989
160Absence seizures (HP:0002121)1.70170168
161Absent eyebrow (HP:0002223)1.69091078
162Narrow forehead (HP:0000341)1.68369550
163Left ventricular hypertrophy (HP:0001712)1.68275906
164Adrenal hypoplasia (HP:0000835)1.67256423
165Gaze-evoked nystagmus (HP:0000640)1.67083637
166Enlarged penis (HP:0000040)1.66443837
167Adactyly (HP:0009776)1.65714424
168Aplasia/Hypoplasia of the tongue (HP:0010295)1.65531814
169Overgrowth (HP:0001548)1.65484526
170Optic nerve hypoplasia (HP:0000609)1.63881774
171Protrusio acetabuli (HP:0003179)1.63488028
172Hyperventilation (HP:0002883)1.62950197
173Aplasia/Hypoplasia of the tibia (HP:0005772)1.62700576
174Hyperglycinemia (HP:0002154)1.62455296

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERBB36.96314185
2MAPK153.76867244
3BMPR23.26385402
4SRPK13.18254910
5PHKG22.68255409
6PHKG12.68255409
7RIPK12.62382393
8NUAK12.28094830
9MAP2K72.28085557
10MAPK132.26053543
11STK242.08155602
12PLK42.06609600
13NTRK11.99761775
14ADRBK21.95837588
15EEF2K1.90037323
16SIK21.89839105
17MAP3K61.85298607
18BMPR1B1.84631065
19PNCK1.81625149
20ARAF1.80790010
21MARK11.78368788
22PRPF4B1.76337108
23STK38L1.72325381
24DAPK21.69305714
25NTRK21.66066315
26MAP3K41.58179969
27DYRK31.52587475
28DYRK21.51427936
29MAP3K101.51185966
30MAP3K91.51085843
31MOS1.43378148
32MAPKAPK31.42991047
33OBSCN1.38850185
34STK161.36123882
35CSNK1A1L1.35780875
36TGFBR21.34463388
37PINK11.33805601
38WNK41.31031240
39WNK31.29346227
40CAMK1G1.25165100
41CSNK1G31.19000924
42PAK31.16801813
43CSNK1G21.15751974
44PLK21.14130643
45CAMK2B1.13360239
46CAMK2D1.12901296
47CDK51.11051947
48CAMK1D1.06268628
49CASK1.00455178
50PIM20.99823253
51EPHB20.96312690
52MAP2K40.95776132
53CSNK1G10.94724543
54NTRK30.93839119
55FGFR20.91273249
56PAK60.91234282
57CDK90.90644856
58EPHA40.89938538
59TIE10.89683399
60SIK30.88537306
61SGK2230.88408376
62SGK4940.88408376
63BRAF0.88066335
64MUSK0.87271173
65TRIM280.86184336
66ICK0.85044298
67MINK10.84342688
68MAP4K20.82521885
69MKNK10.81352933
70LATS20.80185106
71ILK0.80005469
72IRAK20.76854543
73CAMK2G0.76718911
74CDK30.76014272
75NEK20.73781356
76DYRK1A0.72874753
77UHMK10.70573595
78ADRBK10.70508625
79PRKCE0.69659615
80GRK10.68493520
81AKT30.66615619
82FGFR30.66576547
83PKN10.66499083
84PRKG10.63640683
85WNK10.63534683
86DYRK1B0.60840109
87STK390.60540936
88SGK20.58373814
89RPS6KA40.57286791
90CSNK1D0.57067739
91CAMK10.56357796
92NLK0.55813836
93RPS6KA20.55593819
94PRKACA0.55190742
95LATS10.55037937
96CDK150.54747699
97CDK180.54680082
98IRAK10.54195227
99PLK30.53890586
100BRD40.51285875
101CDK140.50420264
102CSNK1E0.50328196
103PRKAA10.50058133
104CDK11A0.49550161
105MAPKAPK20.48927126
106CAMKK10.46812692
107RPS6KA60.42811326
108PRKCH0.42795837
109DAPK10.42685472
110TRPM70.41765004
111MARK20.41120787
112CAMK40.40986433
113PRKACB0.39705859
114KSR10.39153611
115AKT20.39129773
116PRKCZ0.38441360
117CLK10.37920001
118PRKCG0.37858473
119FRK0.36698479
120OXSR10.36653577
121PRKACG0.36539333
122TNIK0.36437548
123DDR20.36119404
124ROCK20.35900855
125RPS6KA30.35118048
126TGFBR10.34841364
127AURKA0.34182006
128DAPK30.31629349
129TYRO30.30760658
130ZAK0.30063674
131SIK10.29957455
132MAPK90.28827347
133HIPK20.28439935
134IRAK40.27771806
135MKNK20.27703340
136ROCK10.27664423
137FER0.26591133
138CAMK2A0.22358689
139PRKAA20.21803812
140STK110.21723235
141YES10.21142235
142ERBB20.19617152
143CAMKK20.19275326
144LIMK10.18995702
145PDGFRA0.18307398
146BCR0.17942278
147MAPK80.17816023

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047409.19450529
2Phototransduction_Homo sapiens_hsa047443.48903845
3Nicotine addiction_Homo sapiens_hsa050333.41822565
4Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.58117776
5Notch signaling pathway_Homo sapiens_hsa043302.36731094
6Taste transduction_Homo sapiens_hsa047422.09110160
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.05192563
8Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.01639592
9Cocaine addiction_Homo sapiens_hsa050301.91399314
10Morphine addiction_Homo sapiens_hsa050321.85853275
11Dopaminergic synapse_Homo sapiens_hsa047281.84087153
12Circadian entrainment_Homo sapiens_hsa047131.80577231
13Dorso-ventral axis formation_Homo sapiens_hsa043201.71636636
14Cholinergic synapse_Homo sapiens_hsa047251.67425983
15Alcoholism_Homo sapiens_hsa050341.60794383
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.57222065
17Serotonergic synapse_Homo sapiens_hsa047261.51337323
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.47659091
19Propanoate metabolism_Homo sapiens_hsa006401.45181279
20Colorectal cancer_Homo sapiens_hsa052101.43751655
21GABAergic synapse_Homo sapiens_hsa047271.41537194
22Glutamatergic synapse_Homo sapiens_hsa047241.39491507
23Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.34555553
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.32850123
25Synaptic vesicle cycle_Homo sapiens_hsa047211.27971727
26SNARE interactions in vesicular transport_Homo sapiens_hsa041301.26674283
27Axon guidance_Homo sapiens_hsa043601.22163544
28Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.21996730
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.14434641
30Huntingtons disease_Homo sapiens_hsa050161.13905729
31Long-term depression_Homo sapiens_hsa047301.13229890
32Insulin secretion_Homo sapiens_hsa049111.11313798
33ECM-receptor interaction_Homo sapiens_hsa045121.11143619
34Pyruvate metabolism_Homo sapiens_hsa006201.07698840
35Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.04145351
36Chronic myeloid leukemia_Homo sapiens_hsa052201.01106026
37Protein digestion and absorption_Homo sapiens_hsa049741.01018288
38Linoleic acid metabolism_Homo sapiens_hsa005910.99987023
39Ether lipid metabolism_Homo sapiens_hsa005650.99199662
40Endometrial cancer_Homo sapiens_hsa052130.95221746
41Parkinsons disease_Homo sapiens_hsa050120.93829787
42Vascular smooth muscle contraction_Homo sapiens_hsa042700.93040047
43Viral myocarditis_Homo sapiens_hsa054160.92943869
44Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.91394373
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.90291685
46mRNA surveillance pathway_Homo sapiens_hsa030150.88129920
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.87379244
48Tight junction_Homo sapiens_hsa045300.85764656
49Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85719541
50Pancreatic cancer_Homo sapiens_hsa052120.85310477
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.84312982
52beta-Alanine metabolism_Homo sapiens_hsa004100.83517764
53Aldosterone synthesis and secretion_Homo sapiens_hsa049250.83338919
54cAMP signaling pathway_Homo sapiens_hsa040240.83191182
55Ras signaling pathway_Homo sapiens_hsa040140.83066358
56Glioma_Homo sapiens_hsa052140.82684946
57Circadian rhythm_Homo sapiens_hsa047100.81932355
58Melanogenesis_Homo sapiens_hsa049160.81497297
59Collecting duct acid secretion_Homo sapiens_hsa049660.80493734
60Insulin signaling pathway_Homo sapiens_hsa049100.79644440
61Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.79609423
62Salivary secretion_Homo sapiens_hsa049700.78315350
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.78306446
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.77607972
65Glucagon signaling pathway_Homo sapiens_hsa049220.77237024
66Hepatitis C_Homo sapiens_hsa051600.76859078
67AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76782051
68Alzheimers disease_Homo sapiens_hsa050100.76355211
69Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.76009174
70GnRH signaling pathway_Homo sapiens_hsa049120.72779227
71Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72177727
72Amphetamine addiction_Homo sapiens_hsa050310.71201026
73Vibrio cholerae infection_Homo sapiens_hsa051100.69752572
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69395665
75FoxO signaling pathway_Homo sapiens_hsa040680.69017831
76Glycerolipid metabolism_Homo sapiens_hsa005610.68983779
77Systemic lupus erythematosus_Homo sapiens_hsa053220.68020169
78Basal transcription factors_Homo sapiens_hsa030220.65736413
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.64790103
80ErbB signaling pathway_Homo sapiens_hsa040120.63936974
81MAPK signaling pathway_Homo sapiens_hsa040100.63886949
82Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.63489510
83Oxidative phosphorylation_Homo sapiens_hsa001900.62672171
84Adherens junction_Homo sapiens_hsa045200.60016594
85Nitrogen metabolism_Homo sapiens_hsa009100.59467989
86Fatty acid biosynthesis_Homo sapiens_hsa000610.59467865
87Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59144291
88Gastric acid secretion_Homo sapiens_hsa049710.58329618
89Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.57964172
90Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57950233
91Thyroid hormone synthesis_Homo sapiens_hsa049180.57323039
92Ovarian steroidogenesis_Homo sapiens_hsa049130.56917059
93Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.56079579
94Melanoma_Homo sapiens_hsa052180.54980715
95Butanoate metabolism_Homo sapiens_hsa006500.54710565
96Calcium signaling pathway_Homo sapiens_hsa040200.53657158
97Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52190190
98Pathways in cancer_Homo sapiens_hsa052000.51651684
99Dilated cardiomyopathy_Homo sapiens_hsa054140.50493303
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49765582
101Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49402459
102Renin secretion_Homo sapiens_hsa049240.48998289
103Basal cell carcinoma_Homo sapiens_hsa052170.48925897
104Sulfur relay system_Homo sapiens_hsa041220.48102237
105Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47953649
106Focal adhesion_Homo sapiens_hsa045100.47923763
107Oxytocin signaling pathway_Homo sapiens_hsa049210.47464126
108Hedgehog signaling pathway_Homo sapiens_hsa043400.45516605
109Prion diseases_Homo sapiens_hsa050200.44698148
110Cardiac muscle contraction_Homo sapiens_hsa042600.44108093
111Regulation of autophagy_Homo sapiens_hsa041400.43639066
112Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43000813
113Estrogen signaling pathway_Homo sapiens_hsa049150.42257145
114Rap1 signaling pathway_Homo sapiens_hsa040150.42002513
115TGF-beta signaling pathway_Homo sapiens_hsa043500.41916892
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41367971
117Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41340504
118Wnt signaling pathway_Homo sapiens_hsa043100.41122484
119Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.40544187
120PPAR signaling pathway_Homo sapiens_hsa033200.39474248
121Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39292890
122Gap junction_Homo sapiens_hsa045400.38255053
123Glycerophospholipid metabolism_Homo sapiens_hsa005640.38190787
124PI3K-Akt signaling pathway_Homo sapiens_hsa041510.37645415
125MicroRNAs in cancer_Homo sapiens_hsa052060.37027848
126Amoebiasis_Homo sapiens_hsa051460.36987844
127Bile secretion_Homo sapiens_hsa049760.36769459
128Oocyte meiosis_Homo sapiens_hsa041140.35694384
129ABC transporters_Homo sapiens_hsa020100.35197539
130Fatty acid degradation_Homo sapiens_hsa000710.34122080
131Chemokine signaling pathway_Homo sapiens_hsa040620.33393192
132Hippo signaling pathway_Homo sapiens_hsa043900.32177477
133Type II diabetes mellitus_Homo sapiens_hsa049300.31804920
134Non-homologous end-joining_Homo sapiens_hsa034500.31793247
135Apoptosis_Homo sapiens_hsa042100.31622489
136Long-term potentiation_Homo sapiens_hsa047200.29500855

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