EBF4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: EBF4 belongs to the conserved Olf/EBF family of helix-loop-helix transcription factors, members of which play important roles in neural development and B-cell maturation (Wang et al., 2002 [PubMed 12139918]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sensory perception of smell (GO:0007608)7.31465537
2neuron cell-cell adhesion (GO:0007158)5.17609736
3sensory perception of chemical stimulus (GO:0007606)4.61344100
4locomotory exploration behavior (GO:0035641)4.34911509
5regulation of short-term neuronal synaptic plasticity (GO:0048172)4.26989310
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.23246776
7layer formation in cerebral cortex (GO:0021819)4.11679830
8axonal fasciculation (GO:0007413)4.11371472
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.04160387
10cell migration in hindbrain (GO:0021535)4.00667079
11synaptic vesicle exocytosis (GO:0016079)3.99236647
12vocalization behavior (GO:0071625)3.98111244
13adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.96105761
14regulation of synapse structural plasticity (GO:0051823)3.92420130
15neuron recognition (GO:0008038)3.84169345
16phosphorelay signal transduction system (GO:0000160)3.78504251
17synaptic vesicle docking involved in exocytosis (GO:0016081)3.75691418
18synaptic vesicle maturation (GO:0016188)3.72127715
19protein localization to cilium (GO:0061512)3.65484138
20lens fiber cell development (GO:0070307)3.63620062
21cell-cell junction maintenance (GO:0045217)3.62692947
22endocardial cushion morphogenesis (GO:0003203)3.61754610
23axon ensheathment in central nervous system (GO:0032291)3.54535249
24central nervous system myelination (GO:0022010)3.54535249
25glutamate secretion (GO:0014047)3.52692639
26regulation of glutamate receptor signaling pathway (GO:1900449)3.50953828
27regulation of synaptic vesicle exocytosis (GO:2000300)3.48483045
28positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.48003332
29postsynaptic membrane organization (GO:0001941)3.47667100
30ganglion development (GO:0061548)3.46677595
31mating behavior (GO:0007617)3.43591702
32dermatan sulfate metabolic process (GO:0030205)3.42970413
33enteric nervous system development (GO:0048484)3.41599654
34negative regulation of microtubule polymerization (GO:0031115)3.39283943
35protein localization to synapse (GO:0035418)3.36151522
36negative regulation of catenin import into nucleus (GO:0035414)3.31307061
37transmission of nerve impulse (GO:0019226)3.28091314
38dopamine receptor signaling pathway (GO:0007212)3.27246014
39exploration behavior (GO:0035640)3.25360858
40presynaptic membrane organization (GO:0097090)3.24479437
41axon extension (GO:0048675)3.23659017
42renal system development (GO:0072001)3.19249121
43activation of protein kinase A activity (GO:0034199)3.18219121
44dendritic spine morphogenesis (GO:0060997)3.17309256
45neurotransmitter secretion (GO:0007269)3.14681170
46mesenchyme morphogenesis (GO:0072132)3.12172893
47dermatan sulfate biosynthetic process (GO:0030208)3.11470843
48regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.09392288
49cerebellar Purkinje cell differentiation (GO:0021702)3.08933611
50detection of calcium ion (GO:0005513)3.06827938
51dendrite morphogenesis (GO:0048813)3.05075421
52negative regulation of cytosolic calcium ion concentration (GO:0051481)3.02249025
53cell junction maintenance (GO:0034331)2.98844985
54planar cell polarity pathway involved in neural tube closure (GO:0090179)2.96919320
55regulation of synaptic vesicle transport (GO:1902803)2.96379461
56olfactory bulb development (GO:0021772)2.95236645
57positive regulation of synapse maturation (GO:0090129)2.94577812
58intraciliary transport (GO:0042073)2.93801683
59protein insertion into membrane (GO:0051205)2.93565824
60auditory behavior (GO:0031223)2.93235128
61cranial nerve morphogenesis (GO:0021602)2.91768453
62negative regulation of synaptic transmission, GABAergic (GO:0032229)2.91141708
63neuron projection regeneration (GO:0031102)2.89406416
64behavioral response to cocaine (GO:0048148)2.89135571
65atrial cardiac muscle cell action potential (GO:0086014)2.88634650
66membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.88103765
67membrane depolarization during action potential (GO:0086010)2.86475208
68axon extension involved in axon guidance (GO:0048846)2.86161389
69neuron projection extension involved in neuron projection guidance (GO:1902284)2.86161389
70regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.85986985
71camera-type eye morphogenesis (GO:0048593)2.85003646
72heart valve formation (GO:0003188)2.84994447
73regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.84901741
74positive regulation of synapse assembly (GO:0051965)2.84817060
75innervation (GO:0060384)2.84365929
76neuronal ion channel clustering (GO:0045161)2.84059848
77cerebellar granule cell differentiation (GO:0021707)2.81284962
78regulation of neuronal synaptic plasticity (GO:0048168)2.81196969
79regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.80279521
80semaphorin-plexin signaling pathway (GO:0071526)2.79747034
81neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.77801524
82pyrimidine nucleobase catabolic process (GO:0006208)2.76519347
83negative regulation of astrocyte differentiation (GO:0048712)2.76275726
84regulation of neurotransmitter secretion (GO:0046928)2.75060525
85collecting duct development (GO:0072044)2.73826098
86positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.73795350
87regulation of respiratory system process (GO:0044065)2.71637375
88establishment of mitochondrion localization (GO:0051654)2.71291498
89hippocampus development (GO:0021766)2.70873089
90chondroitin sulfate catabolic process (GO:0030207)2.70809012
91regulation of axon extension involved in axon guidance (GO:0048841)2.70478630
92calcium-mediated signaling using intracellular calcium source (GO:0035584)2.69846956
93positive regulation of synaptic transmission, GABAergic (GO:0032230)2.69680320
94neuron projection extension (GO:1990138)2.68274923
95negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.68201321
96potassium ion homeostasis (GO:0055075)2.67779463
97synaptic vesicle endocytosis (GO:0048488)2.67666448
98regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.67084373
99regulation of protein kinase A signaling (GO:0010738)2.67062781
100gamma-aminobutyric acid transport (GO:0015812)2.66831103
101presynaptic membrane assembly (GO:0097105)2.65815341
102neurotransmitter-gated ion channel clustering (GO:0072578)2.65313587
103neuronal action potential (GO:0019228)2.65296664
104spinal cord development (GO:0021510)2.64005605
105negative regulation of axon extension involved in axon guidance (GO:0048843)2.63188864
106synapse assembly (GO:0007416)2.62910002
107establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.59763337
108mitochondrion transport along microtubule (GO:0047497)2.59763337
109cochlea morphogenesis (GO:0090103)2.57384390
110protein polyglutamylation (GO:0018095)2.56350508
111regulation of chromatin binding (GO:0035561)2.56131527
112sympathetic nervous system development (GO:0048485)2.55686915
113regulation of neurotransmitter transport (GO:0051588)2.55542120
114positive regulation of dendritic spine development (GO:0060999)2.54166533
115cell communication by electrical coupling (GO:0010644)2.54028064
116establishment of nucleus localization (GO:0040023)2.53853303
117oligodendrocyte differentiation (GO:0048709)2.53724849
118cellular response to glucagon stimulus (GO:0071377)2.52637207
119negative regulation of axon extension (GO:0030517)2.52579731
120regulation of axon guidance (GO:1902667)2.51875126
121regulation of NFAT protein import into nucleus (GO:0051532)2.51535594
122regulation of long-term neuronal synaptic plasticity (GO:0048169)2.51319958
123glutamate receptor signaling pathway (GO:0007215)2.50930735
124cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.50521667
125cellular response to prostaglandin stimulus (GO:0071379)2.49968286
126regulation of respiratory gaseous exchange (GO:0043576)2.49938458
127chemosensory behavior (GO:0007635)2.48124208
128neurotransmitter transport (GO:0006836)2.47986092
129gamma-aminobutyric acid signaling pathway (GO:0007214)2.47936599
130central nervous system projection neuron axonogenesis (GO:0021952)2.47918671
131sodium ion export (GO:0071436)2.47577461
132response to auditory stimulus (GO:0010996)2.47486805
133positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.47393352
134cellular potassium ion homeostasis (GO:0030007)2.47150072
135ionotropic glutamate receptor signaling pathway (GO:0035235)2.47078985
136long-term memory (GO:0007616)2.46556283
137regulation of female receptivity (GO:0045924)2.46441116
138lung epithelium development (GO:0060428)2.43793765
139mechanosensory behavior (GO:0007638)2.42288635
140nephron tubule development (GO:0072080)2.41927176
141axon regeneration (GO:0031103)2.41758374
142potassium ion import (GO:0010107)2.41644063
143nephron tubule formation (GO:0072079)2.41412745
144aorta morphogenesis (GO:0035909)2.40800530
145dendritic spine organization (GO:0097061)2.39702436
146dopaminergic neuron differentiation (GO:0071542)2.39418668
147endothelial cell chemotaxis (GO:0035767)2.36817366
148cerebellar Purkinje cell layer development (GO:0021680)2.36026571
149convergent extension (GO:0060026)2.35320920
150cAMP-mediated signaling (GO:0019933)2.34868025
151astrocyte differentiation (GO:0048708)2.34106116
152peripheral nervous system axon ensheathment (GO:0032292)2.33609062
153myelination in peripheral nervous system (GO:0022011)2.33609062
154negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.33111285
155ventricular trabecula myocardium morphogenesis (GO:0003222)2.31591529
156regulation of synapse assembly (GO:0051963)2.27685188
157nucleobase catabolic process (GO:0046113)2.27054373
158atrioventricular valve morphogenesis (GO:0003181)2.26550132
159membrane hyperpolarization (GO:0060081)2.24770930
160glial cell differentiation (GO:0010001)2.23963646
161negative regulation of axonogenesis (GO:0050771)2.22606276
162metanephric nephron tubule development (GO:0072234)2.22426986

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.81144650
2JARID2_20064375_ChIP-Seq_MESCs_Mouse3.02922729
3* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.98216616
4* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.98216616
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.92054902
6* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.86383942
7GBX2_23144817_ChIP-Seq_PC3_Human2.84438779
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.84138544
9* EED_16625203_ChIP-ChIP_MESCs_Mouse2.83430686
10THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.75837750
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.67582214
12* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.66434463
13* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.63152245
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.58073413
15EZH2_27294783_Chip-Seq_ESCs_Mouse2.37621889
16* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.36235592
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.35720074
18RNF2_27304074_Chip-Seq_ESCs_Mouse2.34356054
19TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.34318677
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.32829147
21DROSHA_22980978_ChIP-Seq_HELA_Human2.21663247
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.21216363
23REST_21632747_ChIP-Seq_MESCs_Mouse2.04020256
24PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.03263636
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.01187019
26BMI1_23680149_ChIP-Seq_NPCS_Mouse1.99768366
27TP63_17297297_ChIP-ChIP_HaCaT_Human1.94220154
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.93662678
29ESR2_21235772_ChIP-Seq_MCF-7_Human1.89307731
30TRIM28_21343339_ChIP-Seq_HEK293_Human1.81246804
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.80093154
32* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.76929855
33LXR_22292898_ChIP-Seq_THP-1_Human1.76578182
34ERG_21242973_ChIP-ChIP_JURKAT_Human1.76323346
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.73097177
36RING1B_27294783_Chip-Seq_ESCs_Mouse1.70083975
37EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.69427053
38RARB_27405468_Chip-Seq_BRAIN_Mouse1.62201905
39CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.59689126
40RING1B_27294783_Chip-Seq_NPCs_Mouse1.59498199
41* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.54749338
42* REST_18959480_ChIP-ChIP_MESCs_Mouse1.53495487
43TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51426215
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50684195
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49033024
46TOP2B_26459242_ChIP-Seq_MCF-7_Human1.44383645
47RNF2_27304074_Chip-Seq_NSC_Mouse1.41461381
48RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.39331155
49RARG_19884340_ChIP-ChIP_MEFs_Mouse1.36599813
50SMAD_19615063_ChIP-ChIP_OVARY_Human1.35776862
51TAF15_26573619_Chip-Seq_HEK293_Human1.34548046
52SMAD4_21799915_ChIP-Seq_A2780_Human1.32452105
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.31331129
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30908751
55ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.28721893
56STAT6_21828071_ChIP-Seq_BEAS2B_Human1.26247384
57NFIB_24661679_ChIP-Seq_LUNG_Mouse1.23451693
58ZFP281_18757296_ChIP-ChIP_E14_Mouse1.23312094
59WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23162012
60IGF1R_20145208_ChIP-Seq_DFB_Human1.23068318
61TP53_20018659_ChIP-ChIP_R1E_Mouse1.22827727
62* KDM2B_26808549_Chip-Seq_K562_Human1.22758657
63MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.20563304
64ESR1_21235772_ChIP-Seq_MCF-7_Human1.20121903
65SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.20114386
66AR_21572438_ChIP-Seq_LNCaP_Human1.17200078
67P300_19829295_ChIP-Seq_ESCs_Human1.16302464
68ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15654111
69RACK7_27058665_Chip-Seq_MCF-7_Human1.14782592
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.14742756
71AR_19668381_ChIP-Seq_PC3_Human1.14381222
72WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.13964402
73POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13635217
74TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13635217
75AHR_22903824_ChIP-Seq_MCF-7_Human1.13404599
76SMC4_20622854_ChIP-Seq_HELA_Human1.12183022
77SOX2_21211035_ChIP-Seq_LN229_Gbm1.12049998
78KDM2B_26808549_Chip-Seq_DND41_Human1.11692450
79ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.11033578
80PIAS1_25552417_ChIP-Seq_VCAP_Human1.10864542
81MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10416263
82ARNT_22903824_ChIP-Seq_MCF-7_Human1.10173122
83SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09717322
84ZFP57_27257070_Chip-Seq_ESCs_Mouse1.08899897
85ZNF274_21170338_ChIP-Seq_K562_Hela1.08012577
86CREB1_26743006_Chip-Seq_LNCaP_Human1.07076635
87* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.05439052
88ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04761528
89EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.03433637
90PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.03413943
91SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.02726555
92TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02485704
93KDM2B_26808549_Chip-Seq_JURKAT_Human1.02161246
94BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.02063017
95NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01975124
96CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01558181
97SA1_27219007_Chip-Seq_ERYTHROID_Human1.01243023
98TP53_18474530_ChIP-ChIP_U2OS_Human1.00426775
99CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00046914
100P68_20966046_ChIP-Seq_HELA_Human0.99507308
101HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.98948031
102* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.98911514
103ZFP281_27345836_Chip-Seq_ESCs_Mouse0.97378044
104NR3C1_23031785_ChIP-Seq_PC12_Mouse0.96936730
105MYC_27129775_Chip-Seq_CORNEA_Mouse0.96430652
106EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.96007730
107RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.95890893
108SMAD3_21741376_ChIP-Seq_ESCs_Human0.95358949
109SMAD4_21741376_ChIP-Seq_EPCs_Human0.94277520
110GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94222722
111YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93643617
112ISL1_27105846_Chip-Seq_CPCs_Mouse0.93267250
113ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93189549
114DNAJC2_21179169_ChIP-ChIP_NT2_Human0.92599993
115TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.92574103
116CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.91107809
117DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.90798897
118TET1_21451524_ChIP-Seq_MESCs_Mouse0.90487429
119SMAD4_21741376_ChIP-Seq_HESCs_Human0.90435436
120SOX3_22085726_ChIP-Seq_NPCs_Mouse0.89824201
121GATA1_26923725_Chip-Seq_HPCs_Mouse0.88776015
122ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.88366962
123* RUNX2_22187159_ChIP-Seq_PCA_Human0.87937906
124RUNX1_27514584_Chip-Seq_MCF-7_Human0.87670070
125TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.87426966
126CTCF_27219007_Chip-Seq_Bcells_Human0.86563238
127ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.86296456
128SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86101974
129STAT3_23295773_ChIP-Seq_U87_Human0.85557916
130TP53_23651856_ChIP-Seq_MEFs_Mouse0.84858490
131TP63_22573176_ChIP-Seq_HFKS_Human0.84843714
132KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.84650663
133SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.83452306
134TCF4_23295773_ChIP-Seq_U87_Human0.82838134
135* OCT4_19829295_ChIP-Seq_ESCs_Human0.82445174
136WT1_19549856_ChIP-ChIP_CCG9911_Human0.82337481
137MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.82160717
138OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.81849202
139KLF4_19829295_ChIP-Seq_ESCs_Human0.81770226
140TET1_21490601_ChIP-Seq_MESCs_Mouse0.81431740
141STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.80437712

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001984_abnormal_olfaction5.69832251
2MP0000566_synostosis4.53445632
3MP0004859_abnormal_synaptic_plasticity3.66626569
4MP0002822_catalepsy2.85427701
5MP0005645_abnormal_hypothalamus_physiol2.82556110
6MP0003880_abnormal_central_pattern2.77964689
7MP0003283_abnormal_digestive_organ2.70229877
8MP0003635_abnormal_synaptic_transmissio2.69087643
9MP0008789_abnormal_olfactory_epithelium2.62528496
10MP0005499_abnormal_olfactory_system2.59298874
11MP0005394_taste/olfaction_phenotype2.59298874
12MP0003122_maternal_imprinting2.56553040
13MP0004270_analgesia2.42355671
14MP0002184_abnormal_innervation2.41473370
15MP0006276_abnormal_autonomic_nervous2.39088359
16MP0003787_abnormal_imprinting2.34246459
17MP0004858_abnormal_nervous_system2.31473594
18MP0000778_abnormal_nervous_system2.21931765
19MP0003136_yellow_coat_color2.17486549
20MP0005423_abnormal_somatic_nervous2.15267485
21MP0002063_abnormal_learning/memory/cond2.13329334
22MP0000537_abnormal_urethra_morphology2.09089616
23MP0002734_abnormal_mechanical_nocicepti2.03113657
24MP0009046_muscle_twitch2.02335762
25MP0009745_abnormal_behavioral_response2.01435376
26MP0002272_abnormal_nervous_system1.98362110
27MP0001486_abnormal_startle_reflex1.97286496
28MP0002653_abnormal_ependyma_morphology1.84005735
29MP0002572_abnormal_emotion/affect_behav1.83182114
30MP0002557_abnormal_social/conspecific_i1.82496347
31MP0002064_seizures1.82274757
32MP0005167_abnormal_blood-brain_barrier1.76794254
33MP0009384_cardiac_valve_regurgitation1.74390177
34MP0003123_paternal_imprinting1.71333291
35MP0005409_darkened_coat_color1.70959846
36MP0009379_abnormal_foot_pigmentation1.68676532
37MP0005377_hearing/vestibular/ear_phenot1.64942347
38MP0003878_abnormal_ear_physiology1.64942347
39MP0005623_abnormal_meninges_morphology1.62430670
40MP0002882_abnormal_neuron_morphology1.56173278
41MP0003121_genomic_imprinting1.55834692
42MP0001958_emphysema1.50893192
43MP0001485_abnormal_pinna_reflex1.49562428
44MP0001968_abnormal_touch/_nociception1.45195238
45MP0002067_abnormal_sensory_capabilities1.40962384
46MP0002752_abnormal_somatic_nervous1.40822630
47MP0004742_abnormal_vestibular_system1.39359620
48MP0005551_abnormal_eye_electrophysiolog1.38283871
49MP0000579_abnormal_nail_morphology1.37362329
50MP0001188_hyperpigmentation1.35834517
51MP0002735_abnormal_chemical_nociception1.35688476
52MP0003690_abnormal_glial_cell1.35391844
53MP0002733_abnormal_thermal_nociception1.33165875
54MP0000678_abnormal_parathyroid_gland1.32813974
55MP0001970_abnormal_pain_threshold1.31937696
56MP0004145_abnormal_muscle_electrophysio1.29865378
57MP0003705_abnormal_hypodermis_morpholog1.29829402
58MP0004811_abnormal_neuron_physiology1.28739722
59MP0000955_abnormal_spinal_cord1.28504465
60MP0001501_abnormal_sleep_pattern1.27315958
61MP0002152_abnormal_brain_morphology1.26705721
62MP0002638_abnormal_pupillary_reflex1.25312019
63MP0003942_abnormal_urinary_system1.24672527
64MP0002909_abnormal_adrenal_gland1.24213918
65MP0002751_abnormal_autonomic_nervous1.20764389
66MP0001440_abnormal_grooming_behavior1.18794764
67MP0001502_abnormal_circadian_rhythm1.17418465
68MP0005503_abnormal_tendon_morphology1.17318194
69MP0000049_abnormal_middle_ear1.16187514
70MP0002249_abnormal_larynx_morphology1.15143847
71MP0002932_abnormal_joint_morphology1.12919281
72MP0002233_abnormal_nose_morphology1.12205779
73MP0010386_abnormal_urinary_bladder1.10716465
74MP0000462_abnormal_digestive_system1.10522368
75MP0005646_abnormal_pituitary_gland1.09749685
76MP0000631_abnormal_neuroendocrine_gland1.09165896
77MP0004885_abnormal_endolymph1.08529141
78MP0000534_abnormal_ureter_morphology1.08150354
79MP0001963_abnormal_hearing_physiology1.05043240
80MP0000751_myopathy1.04735592
81MP0000516_abnormal_urinary_system1.04584103
82MP0005367_renal/urinary_system_phenotyp1.04584103
83MP0002089_abnormal_postnatal_growth/wei1.03875074
84MP0003861_abnormal_nervous_system1.02670109
85MP0000026_abnormal_inner_ear1.01397678
86MP0009250_abnormal_appendicular_skeleto1.00019829
87MP0010030_abnormal_orbit_morphology0.98781830
88MP0006072_abnormal_retinal_apoptosis0.98552510
89MP0002066_abnormal_motor_capabilities/c0.98358921
90MP0005595_abnormal_vascular_smooth0.97153558
91MP0000762_abnormal_tongue_morphology0.96216466
92MP0003119_abnormal_digestive_system0.95150721
93MP0003385_abnormal_body_wall0.94957053
94MP0004924_abnormal_behavior0.92639809
95MP0005386_behavior/neurological_phenoty0.92639809
96MP0005508_abnormal_skeleton_morphology0.91263699
97MP0009053_abnormal_anal_canal0.91114615
98MP0000920_abnormal_myelination0.91099876
99MP0001299_abnormal_eye_distance/0.89310960
100MP0008877_abnormal_DNA_methylation0.88605745
101MP0003279_aneurysm0.88230338
102MP0008569_lethality_at_weaning0.88197170
103MP0005257_abnormal_intraocular_pressure0.88190101
104MP0002229_neurodegeneration0.87230676
105MP0002160_abnormal_reproductive_system0.85799702
106MP0001346_abnormal_lacrimal_gland0.85715960
107MP0000538_abnormal_urinary_bladder0.85206004
108MP0002102_abnormal_ear_morphology0.84655023
109MP0003137_abnormal_impulse_conducting0.83701941
110MP0002736_abnormal_nociception_after0.82686235
111MP0009780_abnormal_chondrocyte_physiolo0.82497679
112MP0004272_abnormal_basement_membrane0.82237927
113MP0003634_abnormal_glial_cell0.80248146
114MP0003879_abnormal_hair_cell0.79128857
115MP0003755_abnormal_palate_morphology0.78550504
116MP0000681_abnormal_thyroid_gland0.78302069
117MP0005195_abnormal_posterior_eye0.78250688
118MP0003632_abnormal_nervous_system0.77216472
119MP0003633_abnormal_nervous_system0.73887531
120MP0001849_ear_inflammation0.73787717
121MP0003935_abnormal_craniofacial_develop0.72212668
122MP0002081_perinatal_lethality0.71854620
123MP0003937_abnormal_limbs/digits/tail_de0.71496094
124MP0001293_anophthalmia0.71108049
125MP0002938_white_spotting0.70485549
126MP0003329_amyloid_beta_deposits0.70067879
127MP0002069_abnormal_eating/drinking_beha0.69855544
128MP0002116_abnormal_craniofacial_bone0.69359327
129MP0005187_abnormal_penis_morphology0.69006967
130MP0003631_nervous_system_phenotype0.68892903
131MP0001529_abnormal_vocalization0.68548596
132MP0004142_abnormal_muscle_tone0.68210223
133MP0004133_heterotaxia0.67770099
134MP0001542_abnormal_bone_strength0.67176452
135MP0003938_abnormal_ear_development0.66048150

Predicted human phenotypes

RankGene SetZ-score
1Obstructive sleep apnea (HP:0002870)4.26527581
2Myokymia (HP:0002411)3.88304956
3Retinal dysplasia (HP:0007973)3.76482033
4Focal motor seizures (HP:0011153)3.52203115
5Febrile seizures (HP:0002373)3.51784374
6Focal seizures (HP:0007359)3.49151849
7Abnormality of the aortic arch (HP:0012303)3.41580184
8Bifid tongue (HP:0010297)3.27133829
9Atonic seizures (HP:0010819)3.24270756
10Turricephaly (HP:0000262)3.14603505
11Limb dystonia (HP:0002451)3.06642918
12Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.01713841
13Hypoventilation (HP:0002791)2.91899140
14Sleep apnea (HP:0010535)2.91674563
15Abnormality of macular pigmentation (HP:0008002)2.87672890
16Agitation (HP:0000713)2.87040275
17Visual hallucinations (HP:0002367)2.86377245
18Neonatal short-limb short stature (HP:0008921)2.84034726
19Epileptic encephalopathy (HP:0200134)2.83558833
20Bronchomalacia (HP:0002780)2.81276295
21Broad face (HP:0000283)2.80232375
22Progressive cerebellar ataxia (HP:0002073)2.80194501
23Partial duplication of the phalanx of hand (HP:0009999)2.71420779
24Termporal pattern (HP:0011008)2.63595943
25Insidious onset (HP:0003587)2.63595943
26Anosmia (HP:0000458)2.60291924
27Abnormality of dentin (HP:0010299)2.58459035
28Neurofibrillary tangles (HP:0002185)2.57673249
29Abnormal respiratory motile cilium physiology (HP:0012261)2.56356755
30Chronic hepatic failure (HP:0100626)2.55467160
31Torticollis (HP:0000473)2.53439329
32Central scotoma (HP:0000603)2.53332948
33Partial duplication of thumb phalanx (HP:0009944)2.53028322
34Rhinitis (HP:0012384)2.46785680
35Action tremor (HP:0002345)2.41885494
36Hyperventilation (HP:0002883)2.41522893
37Shawl scrotum (HP:0000049)2.40292845
38Broad metatarsal (HP:0001783)2.38906557
39Amblyopia (HP:0000646)2.37720954
40Absence seizures (HP:0002121)2.32265731
41Molar tooth sign on MRI (HP:0002419)2.31407783
42Abnormality of midbrain morphology (HP:0002418)2.31407783
43Supernumerary spleens (HP:0009799)2.31390468
44Insomnia (HP:0100785)2.30705215
45Cutaneous finger syndactyly (HP:0010554)2.29314226
46Esophageal atresia (HP:0002032)2.27987217
47Alacrima (HP:0000522)2.27763578
48Aplasia of the phalanges of the hand (HP:0009802)2.26788083
49Aplasia involving bones of the extremities (HP:0009825)2.26788083
50Aplasia involving bones of the upper limbs (HP:0009823)2.26788083
51Narrow nasal bridge (HP:0000446)2.26085159
52Ulnar bowing (HP:0003031)2.25219699
53Generalized tonic-clonic seizures (HP:0002069)2.24963243
54Abnormal ciliary motility (HP:0012262)2.21120935
55Renovascular hypertension (HP:0100817)2.20453455
56Cutaneous syndactyly (HP:0012725)2.20095727
57Craniofacial dystonia (HP:0012179)2.20050556
58Cerebral aneurysm (HP:0004944)2.19968896
59Abnormality of the 4th metacarpal (HP:0010012)2.19528173
60Focal dystonia (HP:0004373)2.16352560
61Vitreoretinal degeneration (HP:0000655)2.14393670
62Fragile skin (HP:0001030)2.14045513
63Gait imbalance (HP:0002141)2.13420152
64Renal duplication (HP:0000075)2.12217724
65Morphological abnormality of the inner ear (HP:0011390)2.12139385
66Supranuclear gaze palsy (HP:0000605)2.11356592
67Genetic anticipation (HP:0003743)2.11301174
68Mitral regurgitation (HP:0001653)2.09197952
69Broad distal phalanx of finger (HP:0009836)2.06725568
70Stridor (HP:0010307)2.06537272
71Depression (HP:0000716)2.04657700
72Neoplasm of the heart (HP:0100544)2.03376553
73Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.01200329
74Atrophic scars (HP:0001075)1.98552777
75Genital tract atresia (HP:0001827)1.98243197
76Coronal craniosynostosis (HP:0004440)1.98200816
77Abnormality of the ischium (HP:0003174)1.97915693
78Vaginal atresia (HP:0000148)1.96025747
79Median cleft lip (HP:0000161)1.94388569
80Menstrual irregularities (HP:0000858)1.94102722
81Omphalocele (HP:0001539)1.93749931
82Midline defect of the nose (HP:0004122)1.93066376
83Restlessness (HP:0000711)1.92299895
84Buphthalmos (HP:0000557)1.91673022
85Abnormality of the diencephalon (HP:0010662)1.91082345
86Dialeptic seizures (HP:0011146)1.90458563
87Bell-shaped thorax (HP:0001591)1.88735781
88Severe Myopia (HP:0011003)1.87385784
89Synostosis of carpal bones (HP:0005048)1.87029437
90Laryngomalacia (HP:0001601)1.86544960
91Lymphangioma (HP:0100764)1.85494990
92Morphological abnormality of the middle ear (HP:0008609)1.85330944
93Hypoplastic ischia (HP:0003175)1.84593199
94Bony spicule pigmentary retinopathy (HP:0007737)1.84541277
95Broad hallux (HP:0010055)1.84113737
96Absent speech (HP:0001344)1.83710712
97Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.83204022
98Short 4th metacarpal (HP:0010044)1.83204022
99Intellectual disability, moderate (HP:0002342)1.82885354
100Bowing of the arm (HP:0006488)1.82657194
101Bowed forearm bones (HP:0003956)1.82657194
102Elfin facies (HP:0004428)1.82634207
103Exotropia (HP:0000577)1.82014369
104Abnormality of cochlea (HP:0000375)1.81932264
105Shallow orbits (HP:0000586)1.81480326
106Back pain (HP:0003418)1.81425858
107Renal dysplasia (HP:0000110)1.80935967
108Bowel diverticulosis (HP:0005222)1.80902354
109Cerebral inclusion bodies (HP:0100314)1.80495224
110Tracheomalacia (HP:0002779)1.78107976
111Congenital primary aphakia (HP:0007707)1.77897870
112Hemiparesis (HP:0001269)1.77525071
113Bladder diverticulum (HP:0000015)1.76490237
114Hyperacusis (HP:0010780)1.76486801
115Facial cleft (HP:0002006)1.76035534
116Postaxial hand polydactyly (HP:0001162)1.76001700
117Megalencephaly (HP:0001355)1.75821483
118Abnormality of the phalanges of the hallux (HP:0010057)1.74528686
119Deviation of the hallux (HP:0010051)1.74503902
120Severe visual impairment (HP:0001141)1.74059378
121Ectopic anus (HP:0004397)1.73603777
122J-shaped sella turcica (HP:0002680)1.73516903
123Generalized hypotonia (HP:0001290)1.73479614
124Wide anterior fontanel (HP:0000260)1.73309544
125Anxiety (HP:0000739)1.73067618
126Mixed hearing impairment (HP:0000410)1.72311101
127Hallux valgus (HP:0001822)1.71899048
128Thin ribs (HP:0000883)1.69940216
129Atelectasis (HP:0100750)1.69878288
130Hyperthyroidism (HP:0000836)1.69510419
131Hypercortisolism (HP:0001578)1.69503837
132Peripheral hypomyelination (HP:0007182)1.69153773
133Specific learning disability (HP:0001328)1.68209165
134Broad finger (HP:0001500)1.67943345
135Absent eyebrow (HP:0002223)1.67856955
136Abnormal respiratory epithelium morphology (HP:0012253)1.67807100
137Abnormal respiratory motile cilium morphology (HP:0005938)1.67807100
138Megalocornea (HP:0000485)1.67676898
139Humeroradial synostosis (HP:0003041)1.67675400
140Synostosis involving the elbow (HP:0003938)1.67675400
14111 pairs of ribs (HP:0000878)1.67304382
142Excessive salivation (HP:0003781)1.67068994
143Drooling (HP:0002307)1.67068994
144Testicular neoplasm (HP:0010788)1.66487640
145Hypoplasia of the iris (HP:0007676)1.66446500
146Broad toe (HP:0001837)1.66397313
147Aqueductal stenosis (HP:0002410)1.66309900
148Aplasia/Hypoplasia of the lens (HP:0008063)1.65611467
149Abnormality of the distal phalanx of the thumb (HP:0009617)1.65042256
150Narrow forehead (HP:0000341)1.64287564
151Failure to thrive in infancy (HP:0001531)1.64132433
152Flat cornea (HP:0007720)1.63852593
153Abnormality of the parietal bone (HP:0002696)1.63601832
154Occipital encephalocele (HP:0002085)1.62855562
155Gastrointestinal atresia (HP:0002589)1.62411608
156Nasal polyposis (HP:0100582)1.62321499
157Fibular aplasia (HP:0002990)1.62074915
158Ankle clonus (HP:0011448)1.62069099
159Congenital malformation of the right heart (HP:0011723)1.61891802
160Double outlet right ventricle (HP:0001719)1.61891802
161Enlarged penis (HP:0000040)1.61750112
162Nephrogenic diabetes insipidus (HP:0009806)1.61680626
163Abnormality of the middle phalanges of the toes (HP:0010183)1.61154109
164Dysphonia (HP:0001618)1.60663334
165Anophthalmia (HP:0000528)1.60209462
166Broad phalanges of the hand (HP:0009768)1.60178537
167Overriding aorta (HP:0002623)1.59739868
168Bifid scrotum (HP:0000048)1.58969455
169Down-sloping shoulders (HP:0200021)1.57904211
170Short nail (HP:0001799)1.56039301
171Cervical subluxation (HP:0003308)1.55740160

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.32403451
2CASK3.20575124
3MAP3K93.16963956
4PHKG12.93913457
5PHKG22.93913457
6MARK12.71870395
7MAP2K62.44926930
8RIPK12.39938061
9NTRK22.21963214
10PAK62.15425658
11SIK12.12094734
12MINK12.09268783
13MAP3K42.01313792
14TAOK21.96146230
15ARAF1.94056152
16PRPF4B1.93389205
17ERBB31.90036991
18DDR21.83066666
19EPHA41.81483129
20NTRK11.72789330
21CAMK1G1.71792109
22MAP2K71.70926041
23MAPK131.63967014
24DAPK21.62396153
25ACVR1B1.61261561
26EPHA21.57352205
27PAK31.53104996
28GRK11.51899800
29PKN11.50536224
30TNIK1.48617810
31CAMK1D1.43540137
32MAP3K71.27166521
33EPHB11.26313755
34KSR21.24271080
35PDGFRB1.23839045
36TYRO31.20494645
37UHMK11.20210174
38CSNK1G21.18340324
39ICK1.17718945
40PRKCG1.17521994
41MAP3K101.14724379
42NME11.11979693
43CDK51.10217952
44TNK21.09119643
45CAMK2B1.08168900
46PLK21.07910194
47PNCK1.07818255
48SRPK11.07365905
49CSNK1A1L1.07097013
50PTK21.04993701
51SIK21.03260364
52CSNK1G31.02883938
53KSR11.00423117
54FGFR40.99654682
55CAMK2D0.99037153
56LMTK20.95750559
57CAMKK20.95712068
58CAMKK10.95674617
59DYRK1A0.95048033
60MAP2K40.94085789
61BRAF0.91247608
62LATS20.88975627
63AKT30.88586107
64MARK20.87839636
65DAPK10.85506292
66RET0.83595500
67EPHB20.81631606
68MET0.80843981
69MAPK150.80407621
70PDGFRA0.80093481
71CAMK2G0.78040309
72SGK4940.77555294
73SGK2230.77555294
74CDC42BPA0.77511450
75ROCK10.76495902
76CAMK2A0.75693294
77EPHA30.75352417
78STK380.74540144
79CSNK1G10.73896187
80MTOR0.73364736
81PKN20.72520870
82GRK50.71773060
83FER0.71614773
84CDK150.69536272
85CDK140.68241995
86CDK180.68209886
87MAPK70.67677074
88EEF2K0.65899550
89RPS6KA20.65702415
90GSK3A0.64386297
91DMPK0.63908947
92DYRK20.63251417
93PRKD30.61662166
94MAP3K60.61128665
95CDK30.59909327
96MAPK120.59864845
97CDK11A0.59245232
98BMX0.58218027
99TLK10.57810393
100FGFR30.57500474
101MAP3K20.55350460
102INSRR0.54833736
103STK390.54444009
104PRKD20.54047711
105PRKCZ0.53402336
106PTK60.53213742
107WNK10.51559553
108PRKAA10.51016437
109CAMK40.50247491
110PRKCE0.49504941
111PTK2B0.48951428
112MAPK100.48657210
113TRIB30.47907806
114CAMK10.47873090
115AKT20.47823928
116MAP3K120.46282470
117LIMK10.44212143
118FYN0.43616708
119FGFR20.43115516
120SGK20.42381186
121WNK40.41742455
122SMG10.41168186
123MAPK80.41003668
124STK110.40759722
125PRKD10.40243659
126MAP3K110.39668628
127HIPK20.38636436
128TAOK10.38547101
129MAPK40.38188339
130DYRK1B0.38074672
131CSNK1E0.36861935
132FGFR10.36649774
133ILK0.36249095
134SGK10.36122086
135ROCK20.35464158
136PDPK10.35265904
137SGK30.35265771
138IRAK10.34944240
139ERBB20.34568423
140TESK10.32992578
141PRKCH0.32411768

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047405.07879693
2Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.78926720
3Nicotine addiction_Homo sapiens_hsa050332.75619209
4Synaptic vesicle cycle_Homo sapiens_hsa047212.63956173
5GABAergic synapse_Homo sapiens_hsa047272.59784991
6Morphine addiction_Homo sapiens_hsa050322.42886734
7Circadian entrainment_Homo sapiens_hsa047132.35414361
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.31088796
9Glutamatergic synapse_Homo sapiens_hsa047242.12050943
10Dopaminergic synapse_Homo sapiens_hsa047282.07211020
11Taste transduction_Homo sapiens_hsa047422.04817386
12Insulin secretion_Homo sapiens_hsa049111.99456154
13Phototransduction_Homo sapiens_hsa047441.89162641
14Cholinergic synapse_Homo sapiens_hsa047251.87801003
15Aldosterone synthesis and secretion_Homo sapiens_hsa049251.77061045
16Amphetamine addiction_Homo sapiens_hsa050311.75048947
17Long-term potentiation_Homo sapiens_hsa047201.73822686
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.73118210
19Serotonergic synapse_Homo sapiens_hsa047261.68618145
20Axon guidance_Homo sapiens_hsa043601.62111836
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.61589011
22Salivary secretion_Homo sapiens_hsa049701.56427225
23Gastric acid secretion_Homo sapiens_hsa049711.52028852
24Renin secretion_Homo sapiens_hsa049241.50527911
25Cocaine addiction_Homo sapiens_hsa050301.50044872
26GnRH signaling pathway_Homo sapiens_hsa049121.48834655
27Melanogenesis_Homo sapiens_hsa049161.45722210
28Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.41514288
29Gap junction_Homo sapiens_hsa045401.39139158
30Oxytocin signaling pathway_Homo sapiens_hsa049211.33956889
31Calcium signaling pathway_Homo sapiens_hsa040201.30671958
32Estrogen signaling pathway_Homo sapiens_hsa049151.26786693
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.26214473
34cAMP signaling pathway_Homo sapiens_hsa040241.26163062
35Long-term depression_Homo sapiens_hsa047301.21699497
36Cardiac muscle contraction_Homo sapiens_hsa042601.17826056
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.17657716
38Vibrio cholerae infection_Homo sapiens_hsa051101.15067755
39Dilated cardiomyopathy_Homo sapiens_hsa054141.12928961
40Collecting duct acid secretion_Homo sapiens_hsa049661.09240325
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06431211
42Alcoholism_Homo sapiens_hsa050341.05843950
43Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.04225387
44Hedgehog signaling pathway_Homo sapiens_hsa043401.03151249
45Glioma_Homo sapiens_hsa052141.00053616
46Ovarian steroidogenesis_Homo sapiens_hsa049130.98708356
47Vascular smooth muscle contraction_Homo sapiens_hsa042700.96570210
48Thyroid hormone synthesis_Homo sapiens_hsa049180.92635468
49Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.90875204
50Protein digestion and absorption_Homo sapiens_hsa049740.90617202
51ErbB signaling pathway_Homo sapiens_hsa040120.87937739
52Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.86664388
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.84577118
54Phospholipase D signaling pathway_Homo sapiens_hsa040720.83760884
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.83423436
56Basal cell carcinoma_Homo sapiens_hsa052170.82677636
57Histidine metabolism_Homo sapiens_hsa003400.81991523
58Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.79329466
59AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.77279386
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.75220857
61Cyanoamino acid metabolism_Homo sapiens_hsa004600.73824503
62Type II diabetes mellitus_Homo sapiens_hsa049300.72784004
63Dorso-ventral axis formation_Homo sapiens_hsa043200.72755749
64Wnt signaling pathway_Homo sapiens_hsa043100.71378425
65Oocyte meiosis_Homo sapiens_hsa041140.71195518
66Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.70501763
67Rap1 signaling pathway_Homo sapiens_hsa040150.70380206
68Prolactin signaling pathway_Homo sapiens_hsa049170.70378471
69Ras signaling pathway_Homo sapiens_hsa040140.69954510
70MAPK signaling pathway_Homo sapiens_hsa040100.69835913
71Glucagon signaling pathway_Homo sapiens_hsa049220.69807647
72Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.68263613
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.68048585
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67984811
75Melanoma_Homo sapiens_hsa052180.66574300
76Prion diseases_Homo sapiens_hsa050200.65313909
77MicroRNAs in cancer_Homo sapiens_hsa052060.65167721
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64219689
79AMPK signaling pathway_Homo sapiens_hsa041520.63821903
80Endometrial cancer_Homo sapiens_hsa052130.62386907
81ABC transporters_Homo sapiens_hsa020100.60095458
82Tight junction_Homo sapiens_hsa045300.59331207
83Circadian rhythm_Homo sapiens_hsa047100.58305868
84Bile secretion_Homo sapiens_hsa049760.58087559
85Insulin signaling pathway_Homo sapiens_hsa049100.57259665
86Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55415901
87Choline metabolism in cancer_Homo sapiens_hsa052310.55376491
88Chronic myeloid leukemia_Homo sapiens_hsa052200.55088144
89Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54930306
90Alzheimers disease_Homo sapiens_hsa050100.54835749
91Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54148343
92Adherens junction_Homo sapiens_hsa045200.52736809
93Pathways in cancer_Homo sapiens_hsa052000.52735920
94Hippo signaling pathway_Homo sapiens_hsa043900.51614332
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51465952
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50556098
97Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.50334357
98Arginine biosynthesis_Homo sapiens_hsa002200.49910861
99PI3K-Akt signaling pathway_Homo sapiens_hsa041510.48826903
100Prostate cancer_Homo sapiens_hsa052150.48720714
101Colorectal cancer_Homo sapiens_hsa052100.48092471
102Parkinsons disease_Homo sapiens_hsa050120.47069217
103Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46832788
104Glycosaminoglycan degradation_Homo sapiens_hsa005310.45505973
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.43912408
106Oxidative phosphorylation_Homo sapiens_hsa001900.42881943
107Huntingtons disease_Homo sapiens_hsa050160.42793961
108Notch signaling pathway_Homo sapiens_hsa043300.41712995
109Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40890248
110Renal cell carcinoma_Homo sapiens_hsa052110.40255318
111Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38539410
112VEGF signaling pathway_Homo sapiens_hsa043700.38165605
113Pancreatic secretion_Homo sapiens_hsa049720.35168262
114ECM-receptor interaction_Homo sapiens_hsa045120.34736343
115Sphingolipid metabolism_Homo sapiens_hsa006000.34446985
116Focal adhesion_Homo sapiens_hsa045100.32616535
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.29987783
118mTOR signaling pathway_Homo sapiens_hsa041500.29300276
119Amoebiasis_Homo sapiens_hsa051460.29200446
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.26843936

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