EBI3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene was identified by its induced expression in B lymphocytes in response Epstein-Barr virus infection. It encodes a secreted glycoprotein belonging to the hematopoietin receptor family, and heterodimerizes with a 28 kDa protein to form interleukin 27 (IL-27). IL-27 regulates T cell and inflammatory responses, in part by activating the Jak/STAT pathway of CD4+ T cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.60407852
2regulation of T-helper 1 cell differentiation (GO:0045625)5.54694694
3neutrophil activation involved in immune response (GO:0002283)5.17086006
4regulation of activation of Janus kinase activity (GO:0010533)4.97554038
5CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.88811869
6response to peptidoglycan (GO:0032494)4.77984245
7type I interferon signaling pathway (GO:0060337)4.50555684
8cellular response to type I interferon (GO:0071357)4.50555684
9response to type I interferon (GO:0034340)4.44068705
10defense response to protozoan (GO:0042832)4.43610484
11immunoglobulin mediated immune response (GO:0016064)4.42036518
12antigen processing and presentation of endogenous antigen (GO:0019883)4.41601080
13positive regulation of T-helper cell differentiation (GO:0045624)4.35446133
14T cell migration (GO:0072678)4.31074764
15positive regulation of natural killer cell differentiation (GO:0032825)4.28114483
16antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.21500212
17antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.21500212
18positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)4.18652210
19regulation of B cell receptor signaling pathway (GO:0050855)4.17682915
20regulation of T-helper 2 cell differentiation (GO:0045628)4.15808291
21myeloid dendritic cell differentiation (GO:0043011)4.14983670
22neutrophil activation (GO:0042119)4.12020609
23negative regulation of inflammatory response to antigenic stimulus (GO:0002862)4.11884792
24positive regulation of interferon-alpha production (GO:0032727)4.11548311
25response to interferon-alpha (GO:0035455)4.05461609
26response to interferon-beta (GO:0035456)4.05283664
27negative regulation of interleukin-17 production (GO:0032700)4.03113408
28myeloid dendritic cell activation (GO:0001773)3.99154078
29granulocyte activation (GO:0036230)3.97973333
30B cell proliferation (GO:0042100)3.92415358
31negative regulation of viral genome replication (GO:0045071)3.92404088
32regulation of interferon-alpha production (GO:0032647)3.91612674
33NIK/NF-kappaB signaling (GO:0038061)3.90820572
34regulation of dendritic cell antigen processing and presentation (GO:0002604)3.89795170
35positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.88144931
36positive regulation of interleukin-12 production (GO:0032735)3.87686361
37B cell receptor signaling pathway (GO:0050853)3.87428291
38response to protozoan (GO:0001562)3.83426794
39B cell mediated immunity (GO:0019724)3.81298420
40* T-helper 1 type immune response (GO:0042088)3.78047338
41positive regulation of antigen processing and presentation (GO:0002579)3.77383275
42positive regulation of interleukin-17 production (GO:0032740)3.76860554
43regulation of T-helper cell differentiation (GO:0045622)3.76441591
44negative regulation of interleukin-12 production (GO:0032695)3.73596562
45regulation of RIG-I signaling pathway (GO:0039535)3.71474342
46B cell homeostasis (GO:0001782)3.71331163
47positive regulation of type 2 immune response (GO:0002830)3.70401719
48cellular response to zinc ion (GO:0071294)3.68496697
49T cell lineage commitment (GO:0002360)3.67750845
50regulation of cytokine secretion involved in immune response (GO:0002739)3.64831124
51lipopolysaccharide-mediated signaling pathway (GO:0031663)3.63839808
52interferon-gamma-mediated signaling pathway (GO:0060333)3.63839219
53positive regulation of gamma-delta T cell activation (GO:0046645)3.63404117
54regulation of vitamin D biosynthetic process (GO:0060556)3.63130798
55cellular response to interferon-beta (GO:0035458)3.61263686
56regulation of interleukin-17 production (GO:0032660)3.59162690
57regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.58714235
58regulation of memory T cell differentiation (GO:0043380)3.55823312
59positive regulation of immunoglobulin mediated immune response (GO:0002891)3.53476336
60positive regulation of B cell mediated immunity (GO:0002714)3.53476336
61regulation of interleukin-12 biosynthetic process (GO:0045075)3.52632999
62negative regulation of myeloid cell apoptotic process (GO:0033033)3.52500881
63positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.51441936
64regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.49884616
65response to muramyl dipeptide (GO:0032495)3.48892435
66regulation of T-helper 1 type immune response (GO:0002825)3.48450895
67activation of MAPKKK activity (GO:0000185)3.48109909
68positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.47195469
69positive regulation of macrophage cytokine production (GO:0060907)3.44922294
70respiratory burst (GO:0045730)3.44350199
71negative regulation of cell killing (GO:0031342)3.42425767
72negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.42425767
73germinal center formation (GO:0002467)3.42394502
74regulation of natural killer cell differentiation (GO:0032823)3.41924196
75detection of bacterium (GO:0016045)3.41603711
76regulation of hypersensitivity (GO:0002883)3.40611579
77dendritic cell differentiation (GO:0097028)3.40134252
78positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.36788614
79positive regulation by symbiont of host defense response (GO:0052509)3.35407228
80modulation by symbiont of host defense response (GO:0052031)3.35407228
81modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.35407228
82modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.35407228
83positive regulation by organism of defense response of other organism involved in symbiotic interact3.35407228
84modulation by symbiont of host immune response (GO:0052553)3.35407228
85natural killer cell mediated cytotoxicity (GO:0042267)3.35176364
86natural killer cell mediated immunity (GO:0002228)3.35176364
87* regulation of interferon-gamma biosynthetic process (GO:0045072)3.34961329
88macrophage activation involved in immune response (GO:0002281)3.33356184
89* positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.30936648
90positive regulation of humoral immune response (GO:0002922)3.30088254
91T cell costimulation (GO:0031295)3.28172901
92regulation of interleukin-2 biosynthetic process (GO:0045076)3.25581922
93regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.24880391
94regulation of antigen processing and presentation (GO:0002577)3.23797717
95lymphocyte costimulation (GO:0031294)3.23152813
96detection of other organism (GO:0098543)3.22558206
97leukocyte aggregation (GO:0070486)3.20177179
98regulation of inflammatory response to antigenic stimulus (GO:0002861)3.20088389
99positive regulation of T-helper 1 type immune response (GO:0002827)3.19476558
100regulation of B cell proliferation (GO:0030888)3.19063911
101positive regulation of B cell differentiation (GO:0045579)3.18920640
102antigen processing and presentation via MHC class Ib (GO:0002475)3.18842712
103regulation of interleukin-12 production (GO:0032655)3.18592779
104positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.18011721
105positive regulation of B cell proliferation (GO:0030890)3.16823668
106positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.13540470
107regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.13180155
108regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.13100716
109regulation of type I interferon-mediated signaling pathway (GO:0060338)3.12461015
110cellular response to exogenous dsRNA (GO:0071360)3.11058196
111leukocyte mediated cytotoxicity (GO:0001909)3.10910372
112regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.10072851
113positive regulation of activated T cell proliferation (GO:0042104)3.08902091
114JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.08835641
115positive regulation of natural killer cell activation (GO:0032816)3.07868069
116negative thymic T cell selection (GO:0045060)3.06824501
117positive regulation of interleukin-2 production (GO:0032743)3.06348546
118regulation of natural killer cell activation (GO:0032814)3.05159887
119positive regulation of interleukin-10 production (GO:0032733)3.03363094
120natural killer cell differentiation (GO:0001779)3.02544950
121positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.02324218
122negative regulation of B cell proliferation (GO:0030889)3.01431948
123natural killer cell activation (GO:0030101)3.01321355
124regulation of gamma-delta T cell activation (GO:0046643)2.98446296
125mature B cell differentiation involved in immune response (GO:0002313)2.97513023
126positive regulation of adaptive immune response based on somatic recombination of immune receptors b2.97371676
127* positive regulation of alpha-beta T cell proliferation (GO:0046641)2.97142823
128positive regulation of defense response to virus by host (GO:0002230)2.95902665
129positive regulation of interferon-beta production (GO:0032728)2.95727008
130regulation of immunoglobulin secretion (GO:0051023)2.95615105
131regulation of interleukin-10 production (GO:0032653)2.95413590
132regulation of B cell apoptotic process (GO:0002902)2.95268552
133positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.93362890
134regulation of B cell differentiation (GO:0045577)2.92664798
135regulation of chronic inflammatory response (GO:0002676)2.92467236
136myeloid cell activation involved in immune response (GO:0002275)2.92418176
137cellular response to interferon-gamma (GO:0071346)2.88988314
138Arp2/3 complex-mediated actin nucleation (GO:0034314)2.88830437
139regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.87457445
140response to interferon-gamma (GO:0034341)2.87434321
141regulation of interferon-beta biosynthetic process (GO:0045357)2.87010220
142hydrogen peroxide biosynthetic process (GO:0050665)2.86684995
143regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.86596092
144negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.86441860
145regulation of growth of symbiont in host (GO:0044126)2.86441860

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.46969671
2IRF8_21731497_ChIP-ChIP_J774_Mouse6.38233280
3IRF8_22096565_ChIP-ChIP_GC-B_Mouse5.28975280
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.99155602
5BP1_19119308_ChIP-ChIP_Hs578T_Human4.40809459
6* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.78311867
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.70886378
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.68947747
9SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.59964581
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.34950708
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.32840318
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.22826559
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.21696007
14MYB_21317192_ChIP-Seq_ERMYB_Mouse3.07377572
15STAT4_19710469_ChIP-ChIP_TH1__Mouse3.03355021
16SCL_19346495_ChIP-Seq_HPC-7_Human2.76708326
17* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.73195753
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.65577107
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.62485192
20* SPI1_23547873_ChIP-Seq_NB4_Human2.61567925
21RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.52721871
22SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.33881488
23Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.27623176
24* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.16337745
25TP63_17297297_ChIP-ChIP_HaCaT_Human2.16080102
26TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.05610853
27MYB_26560356_Chip-Seq_TH2_Human2.04928912
28* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.02284769
29MAF_26560356_Chip-Seq_TH1_Human1.91091433
30BRD4_27068464_Chip-Seq_AML-cells_Mouse1.86751129
31ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.85081760
32LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.83909325
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.83389711
34LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.81570700
35MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.81004205
36VDR_24763502_ChIP-Seq_THP-1_Human1.79862355
37MYB_26560356_Chip-Seq_TH1_Human1.77692731
38VDR_21846776_ChIP-Seq_THP-1_Human1.76741075
39RUNX1_22412390_ChIP-Seq_EML_Mouse1.71590329
40STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.66787694
41RUNX_20019798_ChIP-Seq_JUKART_Human1.63784020
42FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.61934780
43PU_27001747_Chip-Seq_BMDM_Mouse1.56079132
44CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.53070228
45TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.51466460
46CIITA_25753668_ChIP-Seq_RAJI_Human1.50944577
47CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.50617593
48SPI1_23127762_ChIP-Seq_K562_Human1.49889046
49LXR_22292898_ChIP-Seq_THP-1_Human1.49888427
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.47219115
51GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.44711426
52* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.43045544
53KDM2B_26808549_Chip-Seq_SUP-B15_Human1.38845757
54GATA2_22383799_ChIP-Seq_G1ME_Mouse1.37759973
55MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.36371087
56HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.34649410
57ERG_20887958_ChIP-Seq_HPC-7_Mouse1.34231028
58PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.33796874
59CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32315577
60KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.29812643
61CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.27631224
62GATA3_26560356_Chip-Seq_TH2_Human1.27135527
63UTX_26944678_Chip-Seq_JUKART_Human1.26702509
64GATA1_22025678_ChIP-Seq_K562_Human1.26465189
65SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25160785
66SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.25122332
67SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.23339064
68GATA3_27048872_Chip-Seq_THYMUS_Human1.22235063
69HOXB4_20404135_ChIP-ChIP_EML_Mouse1.21597956
70VDR_24787735_ChIP-Seq_THP-1_Human1.19445894
71PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19103607
72PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18802970
73GATA1_22383799_ChIP-Seq_G1ME_Mouse1.16609425
74PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16250234
75E2F7_22180533_ChIP-Seq_HELA_Human1.15434882
76VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.13516698
77THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.13262049
78KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13019242
79* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.11906681
80MAF_26560356_Chip-Seq_TH2_Human1.10364499
81E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.08302331
82KDM2B_26808549_Chip-Seq_DND41_Human1.07626490
83GATA1_19941827_ChIP-Seq_MEL_Mouse1.05671823
84MYC_22102868_ChIP-Seq_BL_Human1.04330353
85NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.02243640
86ELF1_20517297_ChIP-Seq_JURKAT_Human1.01306463
87GATA2_21666600_ChIP-Seq_HMVEC_Human0.99996927
88PU.1_20513432_ChIP-Seq_Bcells_Mouse0.98805445
89BCOR_27268052_Chip-Seq_Bcells_Human0.98388288
90TCF7_22412390_ChIP-Seq_EML_Mouse0.96762659
91STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.94021177
92SMAD_19615063_ChIP-ChIP_OVARY_Human0.93642925
93TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.90469338
94E2F4_17652178_ChIP-ChIP_JURKAT_Human0.90176235
95VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.89357243
96PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.88130546
97DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.86103704
98NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.85705390
99BCL6_27268052_Chip-Seq_Bcells_Human0.83036115
100EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.82033059
101CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81353460
102* NCOR1_26117541_ChIP-Seq_K562_Human0.81224641
103BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.79345835
104EGR1_19032775_ChIP-ChIP_M12_Human0.79074453
105DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.77503595
106SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.77385995
107SRF_21415370_ChIP-Seq_HL-1_Mouse0.75217585
108ELK3_25401928_ChIP-Seq_HUVEC_Human0.74521509
109ETS1_22383799_ChIP-Seq_G1ME_Mouse0.74144060
110VDR_23849224_ChIP-Seq_CD4+_Human0.74052184
111EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.73950894
112* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.73257913
113SPI1_20517297_ChIP-Seq_HL60_Human0.72514558
114EGR1_23403033_ChIP-Seq_LIVER_Mouse0.71833940
115RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.71234464
116CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.69872300
117P300_27268052_Chip-Seq_Bcells_Human0.68473282
118GABP_17652178_ChIP-ChIP_JURKAT_Human0.67430896
119TFEB_21752829_ChIP-Seq_HELA_Human0.67211964
120NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.66265058
121RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.65948964
122STAT1_20625510_ChIP-Seq_HELA_Human0.63504234
123ELK1_19687146_ChIP-ChIP_HELA_Human0.63173479

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.47328400
2MP0009785_altered_susceptibility_to4.64755157
3MP0002148_abnormal_hypersensitivity_rea4.01756075
4* MP0000685_abnormal_immune_system3.83979337
5MP0005671_abnormal_response_to3.71077537
6MP0003436_decreased_susceptibility_to3.68943022
7MP0005000_abnormal_immune_tolerance3.25097499
8* MP0005025_abnormal_response_to3.21545539
9* MP0005387_immune_system_phenotype3.07121223
10* MP0001790_abnormal_immune_system3.07121223
11MP0002419_abnormal_innate_immunity2.94678268
12MP0001800_abnormal_humoral_immune2.83812948
13MP0002452_abnormal_antigen_presenting2.78950777
14* MP0002723_abnormal_immune_serum2.72462940
15MP0003724_increased_susceptibility_to2.60716110
16MP0006082_CNS_inflammation2.57858726
17MP0001819_abnormal_immune_cell2.52370374
18MP0002420_abnormal_adaptive_immunity2.48400371
19MP0003303_peritoneal_inflammation2.22191729
20MP0005645_abnormal_hypothalamus_physiol2.21815161
21MP0001853_heart_inflammation2.19883175
22MP0002166_altered_tumor_susceptibility2.17235901
23MP0005464_abnormal_platelet_physiology2.15837999
24MP0002006_tumorigenesis2.13092819
25MP0004510_myositis2.12888614
26MP0001348_abnormal_lacrimal_gland2.07698431
27* MP0002398_abnormal_bone_marrow2.02451041
28* MP0000716_abnormal_immune_system1.97524480
29MP0002405_respiratory_system_inflammati1.95129809
30MP0001545_abnormal_hematopoietic_system1.89233176
31MP0005397_hematopoietic_system_phenotyp1.89233176
32* MP0001845_abnormal_inflammatory_respons1.87558787
33MP0009764_decreased_sensitivity_to1.85233066
34MP0002139_abnormal_hepatobiliary_system1.84535574
35MP0002163_abnormal_gland_morphology1.80780811
36MP0005310_abnormal_salivary_gland1.79412949
37MP0005451_abnormal_body_composition1.77991093
38* MP0010155_abnormal_intestine_physiology1.75088429
39MP0001533_abnormal_skeleton_physiology1.73402828
40MP0002396_abnormal_hematopoietic_system1.65393847
41* MP0008469_abnormal_protein_level1.62736604
42* MP0002429_abnormal_blood_cell1.61638793
43MP0003763_abnormal_thymus_physiology1.60392354
44MP0000689_abnormal_spleen_morphology1.59989024
45MP0004947_skin_inflammation1.53637081
46MP0002722_abnormal_immune_system1.52923090
47MP0009333_abnormal_splenocyte_physiolog1.52554860
48MP0004808_abnormal_hematopoietic_stem1.43884884
49MP0005174_abnormal_tail_pigmentation1.43201480
50MP0005058_abnormal_lysosome_morphology1.40275420
51MP0002254_reproductive_system_inflammat1.35266615
52MP0000343_altered_response_to1.28203766
53MP0009278_abnormal_bone_marrow1.27189571
54MP0003172_abnormal_lysosome_physiology1.25361397
55MP0005623_abnormal_meninges_morphology1.17563233
56MP0003075_altered_response_to1.16639086
57MP0003191_abnormal_cellular_cholesterol1.13966530
58MP0003866_abnormal_defecation1.13058301
59MP0003453_abnormal_keratinocyte_physiol1.12519026
60MP0003448_altered_tumor_morphology1.12439863
61MP0001346_abnormal_lacrimal_gland1.11441574
62MP0000490_abnormal_crypts_of1.08414894
63MP0003186_abnormal_redox_activity1.07032012
64MP0003183_abnormal_peptide_metabolism1.06287086
65MP0000858_altered_metastatic_potential1.05031801
66MP0002277_abnormal_respiratory_mucosa1.04341169
67MP0001873_stomach_inflammation1.04305801
68MP0002138_abnormal_hepatobiliary_system1.03582627
69MP0005647_abnormal_sex_gland1.00418313
70MP0005379_endocrine/exocrine_gland_phen0.97663352
71MP0000015_abnormal_ear_pigmentation0.97498168
72MP0009763_increased_sensitivity_to0.96383705
73MP0000703_abnormal_thymus_morphology0.94890584
74MP0009697_abnormal_copulation0.94023298
75MP0003045_fibrosis0.93575145
76MP0009840_abnormal_foam_cell0.89828841
77MP0002933_joint_inflammation0.89543535
78MP0008057_abnormal_DNA_replication0.88851179
79MP0001727_abnormal_embryo_implantation0.88398079
80MP0003806_abnormal_nucleotide_metabolis0.85587387
81MP0005075_abnormal_melanosome_morpholog0.82544079
82MP0000465_gastrointestinal_hemorrhage0.82360064
83MP0004782_abnormal_surfactant_physiolog0.82234441
84MP0002998_abnormal_bone_remodeling0.81472915
85MP0000604_amyloidosis0.75794465
86MP0005390_skeleton_phenotype0.73320619
87MP0002095_abnormal_skin_pigmentation0.73070146
88MP0003300_gastrointestinal_ulcer0.71394174
89MP0002877_abnormal_melanocyte_morpholog0.70346572
90MP0002019_abnormal_tumor_incidence0.70266720
91MP0000249_abnormal_blood_vessel0.69252272
92MP0008874_decreased_physiological_sensi0.67956635
93MP0005166_decreased_susceptibility_to0.67929556
94MP0002332_abnormal_exercise_endurance0.67013819
95MP0003943_abnormal_hepatobiliary_system0.65930204
96MP0005165_increased_susceptibility_to0.64964403
97MP0010307_abnormal_tumor_latency0.64892127
98MP0000609_abnormal_liver_physiology0.63336885
99MP0003828_pulmonary_edema0.62078118
100MP0009765_abnormal_xenobiotic_induced0.61076303
101MP0002136_abnormal_kidney_physiology0.60348422
102MP0001919_abnormal_reproductive_system0.59231837
103MP0000371_diluted_coat_color0.58796781
104MP0005167_abnormal_blood-brain_barrier0.58734437
105MP0000681_abnormal_thyroid_gland0.57762805
106MP0002009_preneoplasia0.56709888
107MP0002693_abnormal_pancreas_physiology0.56363181
108MP0001986_abnormal_taste_sensitivity0.55753640
109MP0005584_abnormal_enzyme/coenzyme_acti0.55384777
110MP0008007_abnormal_cellular_replicative0.54899772
111MP0009046_muscle_twitch0.53969011
112MP0005164_abnormal_response_to0.53356907
113MP0010094_abnormal_chromosome_stability0.52669971
114MP0000569_abnormal_digit_pigmentation0.52256566
115MP0000313_abnormal_cell_death0.49887039
116MP0003656_abnormal_erythrocyte_physiolo0.49411160
117MP0001663_abnormal_digestive_system0.48814489
118MP0001851_eye_inflammation0.48583960
119MP0003091_abnormal_cell_migration0.47918198
120MP0008260_abnormal_autophagy0.47506924
121MP0009115_abnormal_fat_cell0.47398097
122MP0002876_abnormal_thyroid_physiology0.45369978
123MP0002132_abnormal_respiratory_system0.44095478

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.41865712
2Recurrent bacterial skin infections (HP:0005406)6.07346997
3Eczematoid dermatitis (HP:0000976)5.80363993
4Recurrent sinusitis (HP:0011108)5.65992174
5Elevated erythrocyte sedimentation rate (HP:0003565)5.60852386
6Myositis (HP:0100614)5.60295198
7Increased IgM level (HP:0003496)4.95960088
8Autoimmune thrombocytopenia (HP:0001973)4.85473095
9Abnormality of macrophages (HP:0004311)4.73537670
10Orchitis (HP:0100796)4.70922123
11Retrobulbar optic neuritis (HP:0100654)4.65698301
12Optic neuritis (HP:0100653)4.65698301
13Recurrent gram-negative bacterial infections (HP:0005420)4.55094126
14Emphysema (HP:0002097)4.48991676
15Mediastinal lymphadenopathy (HP:0100721)4.30624177
16Vasculitis (HP:0002633)4.22630583
17Chronic otitis media (HP:0000389)4.10893126
18Recurrent skin infections (HP:0001581)3.94779441
19Recurrent fungal infections (HP:0002841)3.91970946
20Thrombocytosis (HP:0001894)3.79345549
21Restrictive lung disease (HP:0002091)3.66071335
22Recurrent viral infections (HP:0004429)3.63034414
23Abnormal delayed hypersensitivity skin test (HP:0002963)3.61114387
24Hypergammaglobulinemia (HP:0010702)3.54165560
25Stomatitis (HP:0010280)3.49695250
26Obstructive lung disease (HP:0006536)3.43478734
27Chronic obstructive pulmonary disease (HP:0006510)3.43478734
28Meningitis (HP:0001287)3.28535274
29Cellulitis (HP:0100658)3.22122253
30Gastrointestinal infarctions (HP:0005244)3.20469870
31Abnormality of T cell physiology (HP:0011840)3.17454017
32Basal ganglia calcification (HP:0002135)3.09196453
33Interstitial pulmonary disease (HP:0006530)3.07914780
34Arterial thrombosis (HP:0004420)3.03242911
35Hypertensive crisis (HP:0100735)3.01125492
36Gingivitis (HP:0000230)2.99975081
37Petechiae (HP:0000967)2.99611445
38B lymphocytopenia (HP:0010976)2.99286316
39Periodontitis (HP:0000704)2.98476244
40Abnormality of liposaccharide metabolism (HP:0010968)2.97136599
41Abnormality of glycosphingolipid metabolism (HP:0004343)2.97136599
42Abnormality of glycolipid metabolism (HP:0010969)2.97136599
43Recurrent cutaneous fungal infections (HP:0011370)2.96551220
44Chronic mucocutaneous candidiasis (HP:0002728)2.96551220
45Autoimmune hemolytic anemia (HP:0001890)2.93461834
46Urticaria (HP:0001025)2.87457044
47Keratoconjunctivitis sicca (HP:0001097)2.86270918
48Amaurosis fugax (HP:0100576)2.86164516
49Vacuolated lymphocytes (HP:0001922)2.83622555
50Hemoptysis (HP:0002105)2.80986484
51Pulmonary infiltrates (HP:0002113)2.80770774
52Leukopenia (HP:0001882)2.72021046
53Recurrent bronchitis (HP:0002837)2.70837161
54Gingival bleeding (HP:0000225)2.70791670
55Leukocytosis (HP:0001974)2.69970744
56Agammaglobulinemia (HP:0004432)2.69278740
57Tetraparesis (HP:0002273)2.68329039
58Abnormality of B cell number (HP:0010975)2.67331586
59Lymphoma (HP:0002665)2.66290278
60IgM deficiency (HP:0002850)2.66133173
61IgG deficiency (HP:0004315)2.63545152
62Systemic lupus erythematosus (HP:0002725)2.63399461
63Abnormality of T cells (HP:0002843)2.62259222
64Keratoconjunctivitis (HP:0001096)2.61937164
65Recurrent pneumonia (HP:0006532)2.61353625
66Bronchitis (HP:0012387)2.58923797
67Chest pain (HP:0100749)2.58220392
68Premature loss of primary teeth (HP:0006323)2.57390487
69Encephalitis (HP:0002383)2.55351780
70Spontaneous hematomas (HP:0007420)2.52685182
71Abnormality of cells of the lymphoid lineage (HP:0012140)2.50404117
72Recurrent lower respiratory tract infections (HP:0002783)2.49390437
73Basal cell carcinoma (HP:0002671)2.47676574
74Eosinophilia (HP:0001880)2.46082141
75Panhypogammaglobulinemia (HP:0003139)2.45528684
76Epistaxis (HP:0000421)2.45362099
77Skin rash (HP:0000988)2.39824967
78Increased neuronal autofluorescent lipopigment (HP:0002074)2.39345016
79Xerostomia (HP:0000217)2.38829117
80Granulocytopenia (HP:0001913)2.37900015
81Dry hair (HP:0011359)2.37265218
82Abnormality of the nasal mucosa (HP:0000433)2.35740890
83Pustule (HP:0200039)2.34862534
84Papilloma (HP:0012740)2.34592000
85Verrucae (HP:0200043)2.34592000
86Nasal polyposis (HP:0100582)2.31997259
87Lymphopenia (HP:0001888)2.31136983
88Inflammation of the large intestine (HP:0002037)2.31026478
89Osteomyelitis (HP:0002754)2.28687852
90Abnormality of T cell number (HP:0011839)2.28276767
91Joint swelling (HP:0001386)2.28068416
92IgA deficiency (HP:0002720)2.27657602
93Neutropenia (HP:0001875)2.25862169
94Increased IgE level (HP:0003212)2.24777120
95Squamous cell carcinoma (HP:0002860)2.23823509
96Abnormality of eosinophils (HP:0001879)2.23293435
97Vertebral compression fractures (HP:0002953)2.23163202
98Gastrointestinal stroma tumor (HP:0100723)2.22533227
99Increased cerebral lipofuscin (HP:0011813)2.21406804
100Gastrointestinal inflammation (HP:0004386)2.21061152
101Poor head control (HP:0002421)2.16975450
102Purpura (HP:0000979)2.16851421
103Gangrene (HP:0100758)2.16746448
104Chronic diarrhea (HP:0002028)2.16280789
105Anorexia (HP:0002039)2.16218894
106Colitis (HP:0002583)2.12848988
107Arthralgia (HP:0002829)2.11829989
108Prolonged bleeding time (HP:0003010)2.09120622
109Recurrent otitis media (HP:0000403)2.08327042
110Cholecystitis (HP:0001082)2.07793680
111Abnormal gallbladder physiology (HP:0012438)2.07793680
112Acrocyanosis (HP:0001063)2.07162933
113Chronic sinusitis (HP:0011109)2.06438493
114Thyroiditis (HP:0100646)2.04465709
115Albinism (HP:0001022)2.04220938
116Abnormality of the pleura (HP:0002103)2.04059193
117Onycholysis (HP:0001806)2.00715604
118Viral hepatitis (HP:0006562)2.00684715
119Abnormality of the prostate (HP:0008775)1.98942668
120Fatigue (HP:0012378)1.98458538
121Conical tooth (HP:0000698)1.98423176
122Pulmonary fibrosis (HP:0002206)1.97223513
123Reduced antithrombin III activity (HP:0001976)1.95138557
124Hepatitis (HP:0012115)1.93704565
125Hematochezia (HP:0002573)1.91709576
126Skin ulcer (HP:0200042)1.91163513
127Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.89346541
128Dysostosis multiplex (HP:0000943)1.88611801
129Porencephaly (HP:0002132)1.88324716
130Sepsis (HP:0100806)1.88236350
131Loss of speech (HP:0002371)1.84710690

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.79933191
2IRAK43.72699420
3TBK13.60501879
4PRPF4B3.32374341
5RIPK43.11375673
6JAK33.08022691
7TYK23.05732797
8IKBKE2.97659033
9IKBKB2.76595424
10KIT2.72600093
11MAP4K12.69256958
12BLK2.58847398
13SMG12.50105309
14MAP3K132.37525002
15PIM22.21508798
16FLT32.19154947
17IRAK32.17654735
18VRK12.03531659
19BTK2.02632139
20TXK2.01008672
21DDR21.92936708
22SYK1.82777706
23CSF1R1.80522964
24DAPK31.80044540
25ZAP701.74309906
26CHUK1.73040246
27TLK11.69808771
28TAOK21.68510846
29JAK11.63234053
30NME21.60680138
31TEC1.56662661
32EPHB11.47232931
33FES1.38815628
34MAP3K121.37869303
35ERN11.37206075
36TNIK1.31593204
37ARAF1.31584601
38BMPR21.27902522
39MATK1.26891212
40LYN1.19124983
41PIM11.17795844
42LCK1.17572284
43CSK1.15528824
44HCK1.14958191
45PBK1.14848915
46CDC42BPA1.14658293
47EIF2AK21.11062602
48TAF11.08884161
49TGFBR21.07248787
50TAOK31.07015205
51ADRBK21.05294731
52RPS6KA51.02225515
53ACVR1B0.97395811
54SIK30.95138791
55TGFBR10.94957955
56BCKDK0.93745807
57NEK90.90201714
58MAP2K30.89185165
59NLK0.88287285
60ZAK0.87492783
61VRK20.85942632
62JAK20.85628958
63STK240.83381629
64PKN10.82663417
65IRAK10.81794817
66RPS6KA40.81140040
67ERBB30.79096975
68MAP3K90.75677093
69CCNB10.74209922
70MAPK110.74034059
71YES10.72235753
72PASK0.70976621
73STK40.70175756
74EEF2K0.68902267
75TESK20.68773147
76MAP2K60.65265192
77PRKCD0.64735753
78FGFR40.64409875
79STK100.63686868
80ABL20.63652533
81FGR0.61853194
82CDK120.61215222
83PDGFRA0.60909977
84DAPK10.59704508
85FGFR30.58871256
86MAP3K80.58117066
87SIK20.57310952
88BRAF0.56794451
89MELK0.55031186
90MAP3K110.53697317
91MAPKAPK20.53404835
92CLK10.53273044
93MOS0.52955451
94AURKA0.52783564
95IRAK20.52106335
96TRPM70.51740977
97RAF10.51012255
98LRRK20.50912266
99EPHA30.50096268
100PDK10.48519297
101ABL10.48152312
102MARK30.46307165
103TESK10.46118864
104MST40.44996486
105PTK60.44618209
106NEK10.44606542
107MAPKAPK50.44580657
108INSR0.44363991
109ALK0.42672602
110MAP3K10.42287935
111KDR0.41918060
112MAPK70.41267953
113DAPK20.40206686
114ICK0.39981728
115SIK10.38726516
116TIE10.38130442
117BMPR1B0.37648024
118BRSK20.36596580
119MAP3K100.35725378
120BCR0.35560548
121CDK90.35542124
122GRK70.35485096
123STK160.35212578
124MAP3K50.33983340
125RIPK10.33884353
126MAPK40.33617411
127PRKCQ0.33586249
128MUSK0.33265939
129EGFR0.32843761
130PRKG20.32295337
131MAPKAPK30.31323602
132GRK60.31293898
133WEE10.31275322
134RPS6KA60.30401294
135CDK40.30250740
136CDK60.29409262
137HIPK20.28532196
138EIF2AK30.28307559
139PDPK10.27507252
140KSR20.26783039
141PIK3CG0.25929581
142PRKCH0.24604468
143CDK190.24586349
144TAOK10.24461050

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053304.36648407
2Graft-versus-host disease_Homo sapiens_hsa053323.47920165
3Leishmaniasis_Homo sapiens_hsa051403.20011245
4Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.05515815
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.93195983
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.85318471
7RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.70574676
8Type I diabetes mellitus_Homo sapiens_hsa049402.68541617
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.53584535
10NOD-like receptor signaling pathway_Homo sapiens_hsa046212.46406314
11Measles_Homo sapiens_hsa051622.35773665
12Autoimmune thyroid disease_Homo sapiens_hsa053202.30411927
13Asthma_Homo sapiens_hsa053102.16442056
14Legionellosis_Homo sapiens_hsa051342.13456753
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.11830782
16Pertussis_Homo sapiens_hsa051332.08451584
17Herpes simplex infection_Homo sapiens_hsa051681.97904680
18Osteoclast differentiation_Homo sapiens_hsa043801.96843992
19Influenza A_Homo sapiens_hsa051641.92497316
20Primary immunodeficiency_Homo sapiens_hsa053401.88012370
21TNF signaling pathway_Homo sapiens_hsa046681.84054421
22Rheumatoid arthritis_Homo sapiens_hsa053231.77801972
23African trypanosomiasis_Homo sapiens_hsa051431.75153561
24B cell receptor signaling pathway_Homo sapiens_hsa046621.68017450
25Malaria_Homo sapiens_hsa051441.67768814
26Jak-STAT signaling pathway_Homo sapiens_hsa046301.66017074
27Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.63237354
28Tuberculosis_Homo sapiens_hsa051521.61271470
29Toxoplasmosis_Homo sapiens_hsa051451.61205308
30Staphylococcus aureus infection_Homo sapiens_hsa051501.61046281
31Shigellosis_Homo sapiens_hsa051311.56549119
32Alcoholism_Homo sapiens_hsa050341.50618011
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.46225214
34Antigen processing and presentation_Homo sapiens_hsa046121.43997040
35Chemokine signaling pathway_Homo sapiens_hsa040621.39483280
36Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.36767115
37Viral myocarditis_Homo sapiens_hsa054161.36428081
38Salmonella infection_Homo sapiens_hsa051321.28369597
39Hematopoietic cell lineage_Homo sapiens_hsa046401.26660640
40Apoptosis_Homo sapiens_hsa042101.22682422
41Hepatitis B_Homo sapiens_hsa051611.12605657
42Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.03238807
43Other glycan degradation_Homo sapiens_hsa005110.97594442
44Hepatitis C_Homo sapiens_hsa051600.93760183
45Acute myeloid leukemia_Homo sapiens_hsa052210.93450138
46Proteasome_Homo sapiens_hsa030500.92828176
47SNARE interactions in vesicular transport_Homo sapiens_hsa041300.89820493
48Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.89556487
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.88549635
50Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.88255289
51Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84888367
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.84433178
53Phagosome_Homo sapiens_hsa041450.78979463
54Ribosome_Homo sapiens_hsa030100.76170955
55Prolactin signaling pathway_Homo sapiens_hsa049170.75974697
56Lysosome_Homo sapiens_hsa041420.75757433
57Epstein-Barr virus infection_Homo sapiens_hsa051690.74273751
58T cell receptor signaling pathway_Homo sapiens_hsa046600.73900643
59DNA replication_Homo sapiens_hsa030300.71446241
60Leukocyte transendothelial migration_Homo sapiens_hsa046700.69482828
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68727718
62Platelet activation_Homo sapiens_hsa046110.68376186
63Base excision repair_Homo sapiens_hsa034100.67015854
64AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.65712212
65p53 signaling pathway_Homo sapiens_hsa041150.56465278
66Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53935784
67Chronic myeloid leukemia_Homo sapiens_hsa052200.53375283
68Caffeine metabolism_Homo sapiens_hsa002320.52658992
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.52555041
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52405148
71Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.47964398
72Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47929807
73Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47856319
74Amoebiasis_Homo sapiens_hsa051460.46546511
75Viral carcinogenesis_Homo sapiens_hsa052030.46200616
76Glycosaminoglycan degradation_Homo sapiens_hsa005310.45257308
77Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.41588092
78Pancreatic cancer_Homo sapiens_hsa052120.41128652
79Bladder cancer_Homo sapiens_hsa052190.41099767
80Prion diseases_Homo sapiens_hsa050200.34966175
81Fructose and mannose metabolism_Homo sapiens_hsa000510.33660050
82Mismatch repair_Homo sapiens_hsa034300.32462487
83HTLV-I infection_Homo sapiens_hsa051660.29964929
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.29709888
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.28344625
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.26695202
87HIF-1 signaling pathway_Homo sapiens_hsa040660.24589156
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.24047103
89Systemic lupus erythematosus_Homo sapiens_hsa053220.23862964
90Homologous recombination_Homo sapiens_hsa034400.22112352
91Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.21758210
92VEGF signaling pathway_Homo sapiens_hsa043700.21593170
93Small cell lung cancer_Homo sapiens_hsa052220.20250909
94Pyrimidine metabolism_Homo sapiens_hsa002400.19662874
95Ovarian steroidogenesis_Homo sapiens_hsa049130.16130924
96Tryptophan metabolism_Homo sapiens_hsa003800.15608324
97Type II diabetes mellitus_Homo sapiens_hsa049300.14741215
98Notch signaling pathway_Homo sapiens_hsa043300.14254265
99Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.14150859
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.13252045
101Phenylalanine metabolism_Homo sapiens_hsa003600.12238200
102Pentose phosphate pathway_Homo sapiens_hsa000300.11319294
103Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.10798836
104Non-homologous end-joining_Homo sapiens_hsa034500.09774138
105Pentose and glucuronate interconversions_Homo sapiens_hsa000400.06139122
106Renin-angiotensin system_Homo sapiens_hsa046140.05923999
107Sphingolipid metabolism_Homo sapiens_hsa006000.05210060
108Arachidonic acid metabolism_Homo sapiens_hsa005900.05197022
109Galactose metabolism_Homo sapiens_hsa000520.05192528
110Thyroid cancer_Homo sapiens_hsa052160.05051836
111MAPK signaling pathway_Homo sapiens_hsa040100.04324423
112Nucleotide excision repair_Homo sapiens_hsa034200.03917678
113Prostate cancer_Homo sapiens_hsa052150.02838189
114One carbon pool by folate_Homo sapiens_hsa006700.02231961
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.01411371
116Renal cell carcinoma_Homo sapiens_hsa052110.01305113
117Carbon metabolism_Homo sapiens_hsa01200-0.0368338
118Biosynthesis of amino acids_Homo sapiens_hsa01230-0.0316637
119Non-small cell lung cancer_Homo sapiens_hsa05223-0.0133800

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