ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of female gonad development (GO:2000194)	9.60429555
2	piRNA metabolic process (GO:0034587)	8.94538075
3	meiotic cell cycle (GO:0051321)	8.28326638
4	regulation of meiosis I (GO:0060631)	8.14884401
5	regulation of acrosome reaction (GO:0060046)	7.34621480
6	oocyte development (GO:0048599)	7.14729735
7	DNA methylation involved in gamete generation (GO:0043046)	6.82358317
8	female gamete generation (GO:0007292)	6.70169155
9	retinal cone cell development (GO:0046549)	6.53110189
10	regulation of histone H3-K9 methylation (GO:0051570)	6.44415055
11	positive regulation of histone H3-K4 methylation (GO:0051571)	6.37340163
12	multicellular organism reproduction (GO:0032504)	6.18532418
13	glycine transport (GO:0015816)	6.15689610
14	regulation of cell maturation (GO:1903429)	5.52065932
15	synapsis (GO:0007129)	5.48457432
16	regulation of steroid hormone secretion (GO:2000831)	5.41521061
17	gene silencing by RNA (GO:0031047)	5.40956374
18	mitotic chromosome condensation (GO:0007076)	5.38097337
19	negative regulation of histone methylation (GO:0031061)	5.21648056
20	negative regulation of reproductive process (GO:2000242)	5.19004712
21	positive regulation of mitotic sister chromatid separation (GO:1901970)	5.01985304
22	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	5.01985304
23	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	5.01985304
24	protein localization to chromosome, centromeric region (GO:0071459)	4.99181017
25	positive regulation of gastrulation (GO:2000543)	4.88088901
26	protein kinase C signaling (GO:0070528)	4.83361883
27	protein localization to kinetochore (GO:0034501)	4.80883425
28	centriole replication (GO:0007099)	4.78362526
29	mitotic metaphase plate congression (GO:0007080)	4.76947650
30	synaptonemal complex assembly (GO:0007130)	4.68845668
31	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	4.64870840
32	chromosome organization involved in meiosis (GO:0070192)	4.59866079
33	positive regulation of chromosome segregation (GO:0051984)	4.55881510
34	histone H3-K9 demethylation (GO:0033169)	4.48677217
35	L-amino acid import (GO:0043092)	4.43816616
36	regulation of meiosis (GO:0040020)	4.40407267
37	establishment of chromosome localization (GO:0051303)	4.35860357
38	attachment of spindle microtubules to kinetochore (GO:0008608)	4.34412643
39	positive regulation of humoral immune response (GO:0002922)	4.26448704
40	male meiosis I (GO:0007141)	4.25775388
41	primitive streak formation (GO:0090009)	4.20984458
42	synaptonemal complex organization (GO:0070193)	4.20316164
43	male meiosis (GO:0007140)	4.15764018
44	oogenesis (GO:0048477)	4.06774218
45	CENP-A containing nucleosome assembly (GO:0034080)	4.05218712
46	reproduction (GO:0000003)	4.03274806
47	positive regulation of histone methylation (GO:0031062)	3.96139988
48	nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)	3.94809031
49	protein localization to chromosome (GO:0034502)	3.93790637
50	translesion synthesis (GO:0019985)	3.90210233
51	positive regulation of uterine smooth muscle contraction (GO:0070474)	3.84528121
52	metaphase plate congression (GO:0051310)	3.83928418
53	labyrinthine layer development (GO:0060711)	3.80406085
54	phosphorelay signal transduction system (GO:0000160)	3.75455976
55	positive regulation of reproductive process (GO:2000243)	3.74175360
56	meiotic nuclear division (GO:0007126)	3.72463691
57	regulation of histone H3-K4 methylation (GO:0051569)	3.69123601
58	regulation of meiotic cell cycle (GO:0051445)	3.68457714
59	meiotic cell cycle process (GO:1903046)	3.67311588
60	regulation of spindle organization (GO:0090224)	3.66349980
61	chromatin remodeling at centromere (GO:0031055)	3.66342890
62	fertilization (GO:0009566)	3.65684331
63	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	3.62004763
64	DNA methylation (GO:0006306)	3.57916234
65	DNA alkylation (GO:0006305)	3.57916234
66	regulation of steroid hormone biosynthetic process (GO:0090030)	3.56873217
67	DNA replication-dependent nucleosome assembly (GO:0006335)	3.56569169
68	DNA replication-dependent nucleosome organization (GO:0034723)	3.56569169
69	relaxation of smooth muscle (GO:0044557)	3.52199867
70	gene silencing (GO:0016458)	3.51507458
71	DNA damage induced protein phosphorylation (GO:0006975)	3.51248635
72	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	3.50535956
73	meiosis I (GO:0007127)	3.48551501
74	regulation of spindle checkpoint (GO:0090231)	3.45230215
75	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	3.40847524
76	regulation of histone methylation (GO:0031060)	3.36180382
77	positive regulation of meiosis (GO:0045836)	3.35046673
78	negative regulation of cAMP-mediated signaling (GO:0043951)	3.34346413
79	negative regulation of execution phase of apoptosis (GO:1900118)	3.32257531
80	binding of sperm to zona pellucida (GO:0007339)	3.32254675
81	regulation of double-strand break repair via homologous recombination (GO:0010569)	3.31676025
82	somite rostral/caudal axis specification (GO:0032525)	3.31581337
83	centriole assembly (GO:0098534)	3.28546021
84	N-terminal protein amino acid acetylation (GO:0006474)	3.25429578
85	negative regulation of hormone biosynthetic process (GO:0032353)	3.19168423
86	regulation of reproductive process (GO:2000241)	3.18870439
87	regulation of chromatin silencing (GO:0031935)	3.17221186
88	histone exchange (GO:0043486)	3.17160892
89	DNA replication-independent nucleosome assembly (GO:0006336)	3.15987081
90	DNA replication-independent nucleosome organization (GO:0034724)	3.15987081
91	single fertilization (GO:0007338)	3.15165628
92	negative regulation of hormone metabolic process (GO:0032351)	3.13456495
93	positive regulation of meiotic cell cycle (GO:0051446)	3.11652444
94	neuron fate determination (GO:0048664)	3.10591416
95	regulation of female receptivity (GO:0045924)	3.03776475
96	negative regulation of histone modification (GO:0031057)	3.02956174
97	regulation of cytokine production involved in inflammatory response (GO:1900015)	2.99434111
98	amino acid import (GO:0043090)	2.98294403
99	chromatin assembly or disassembly (GO:0006333)	2.96903971
100	regulation of DNA methylation (GO:0044030)	11.4942659

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	4.72482840
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.63702445
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.46212786
4	E2F7_22180533_ChIP-Seq_HELA_Human	3.80574324
5	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	3.46385474
6	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	3.46385474
7	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	3.46385474
8	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	3.12742286
9	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.88519292
10	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.74121972
11	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.71004049
12	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.60440098
13	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.58197225
14	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	2.30516470
15	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.22813654
16	GBX2_23144817_ChIP-Seq_PC3_Human	2.18472055
17	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.17009486
18	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.00970086
19	EZH2_22144423_ChIP-Seq_EOC_Human	13.4536293
20	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.92381610
21	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.68410086
22	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.68341580
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.53483918
24	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.50379508
25	AR_21909140_ChIP-Seq_LNCAP_Human	1.47208532
26	IRF1_19129219_ChIP-ChIP_H3396_Human	1.43704304
27	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.42185403
28	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.41746860
29	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.39139737
30	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.34333369
31	CBP_20019798_ChIP-Seq_JUKART_Human	1.32058921
32	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.32058921
33	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.31956037
34	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.28161487
35	TCF4_23295773_ChIP-Seq_U87_Human	1.26484610
36	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.26393861
37	HTT_18923047_ChIP-ChIP_STHdh_Human	1.12865313
38	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.11625155
39	AR_25329375_ChIP-Seq_VCAP_Human	1.11187758
40	SMAD4_21799915_ChIP-Seq_A2780_Human	1.10650957
41	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.08919687
42	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.06475966
43	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.06161168
44	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.03972926
45	EWS_26573619_Chip-Seq_HEK293_Human	1.02793982
46	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.01141658
47	NANOG_20526341_ChIP-Seq_ESCs_Human	1.01087479
48	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.99877995
49	STAT3_23295773_ChIP-Seq_U87_Human	0.99661454
50	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.99267993
51	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.98664037
52	RUNX2_22187159_ChIP-Seq_PCA_Human	0.98368241
53	CBP_21632823_ChIP-Seq_H3396_Human	0.98257538
54	GF1_26923725_Chip-Seq_HPCs_Mouse	0.96431072
55	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	0.94473394
56	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.93800055
57	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.92824720
58	TP53_16413492_ChIP-PET_HCT116_Human	0.92022963
59	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.91932432
60	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.91163161
61	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.90488209
62	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.89805576
63	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.88896933
64	P300_19829295_ChIP-Seq_ESCs_Human	0.88759846
65	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.88622341
66	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.87623673
67	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.87474153
68	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.86681235
69	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.85375993
70	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.85328724
71	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.83904611
72	AHR_22903824_ChIP-Seq_MCF-7_Human	0.83754020
73	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.81786471
74	SMRT_27268052_Chip-Seq_Bcells_Human	0.80374938
75	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.80175927
76	PKCTHETA_26484144_Chip-Seq_BREAST_Human	0.79722603
77	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.79001014
78	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.77882468
79	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.77511151
80	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.77399153
81	RNF2_27304074_Chip-Seq_NSC_Mouse	0.77146030
82	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.76755136
83	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.76755136
84	VDR_22108803_ChIP-Seq_LS180_Human	0.74762521
85	GATA1_19941827_ChIP-Seq_MEL86_Mouse	0.73132155
86	TP53_22573176_ChIP-Seq_HFKS_Human	0.72670429
87	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.69017502
88	GATA3_26560356_Chip-Seq_TH1_Human	0.68191176
89	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.68189956
90	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.67821450
91	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.67512346
92	REST_21632747_ChIP-Seq_MESCs_Mouse	0.65689277
93	DROSHA_22980978_ChIP-Seq_HELA_Human	0.65508209
94	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.64967721
95	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.64564546
96	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	0.64468246
97	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.64146378
98	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.64117442
99	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.63821423
100	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.63752648

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003718_maternal_effect	8.43948924
2	MP0008877_abnormal_DNA_methylation	4.80699826
3	MP0006292_abnormal_olfactory_placode	4.47469029
4	MP0008789_abnormal_olfactory_epithelium	4.21182762
5	MP0005499_abnormal_olfactory_system	3.73200043
6	MP0005394_taste/olfaction_phenotype	3.73200043
7	MP0005395_other_phenotype	3.37179587
8	MP0010234_abnormal_vibrissa_follicle	3.16652118
9	MP0002139_abnormal_hepatobiliary_system	3.13102452
10	MP0003890_abnormal_embryonic-extraembry	3.11735688
11	MP0005360_urolithiasis	3.07924131
12	MP0008057_abnormal_DNA_replication	2.81617113
13	MP0003693_abnormal_embryo_hatching	2.70203472
14	MP0002138_abnormal_hepatobiliary_system	2.67843668
15	MP0003699_abnormal_female_reproductive	2.47805370
16	MP0003879_abnormal_hair_cell	2.46313089
17	MP0010030_abnormal_orbit_morphology	2.43762392
18	MP0002210_abnormal_sex_determination	2.28088760
19	MP0001929_abnormal_gametogenesis	2.27770549
20	MP0002234_abnormal_pharynx_morphology	2.24779945
21	MP0003950_abnormal_plasma_membrane	2.09886582
22	MP0003077_abnormal_cell_cycle	2.05005547
23	MP0003183_abnormal_peptide_metabolism	1.95782978
24	MP0010094_abnormal_chromosome_stability	1.92054094
25	MP0005410_abnormal_fertilization	1.90120389
26	MP0008058_abnormal_DNA_repair	1.87000947
27	MP0002160_abnormal_reproductive_system	1.82941475
28	MP0000653_abnormal_sex_gland	1.76861804
29	MP0002161_abnormal_fertility/fecundity	1.64807372
30	MP0000566_synostosis	1.55245368
31	MP0003111_abnormal_nucleus_morphology	1.50296463
32	MP0001145_abnormal_male_reproductive	1.45352534
33	MP0009840_abnormal_foam_cell	1.34131897
34	MP0005647_abnormal_sex_gland	1.32244115
35	MP0000427_abnormal_hair_cycle	1.31964908
36	MP0008932_abnormal_embryonic_tissue	1.31518500
37	MP0005646_abnormal_pituitary_gland	1.30557457
38	MP0010307_abnormal_tumor_latency	1.29852200
39	MP0001293_anophthalmia	1.29362771
40	MP0001119_abnormal_female_reproductive	1.27081146
41	MP0000631_abnormal_neuroendocrine_gland	1.25184544
42	MP0000762_abnormal_tongue_morphology	1.24585497
43	MP0003698_abnormal_male_reproductive	1.24014952
44	MP0003252_abnormal_bile_duct	1.22368925
45	MP0003121_genomic_imprinting	1.21199760
46	MP0001730_embryonic_growth_arrest	1.19330858
47	MP0005389_reproductive_system_phenotype	1.13728685
48	MP0001984_abnormal_olfaction	1.10786797
49	MP0002233_abnormal_nose_morphology	1.08084209
50	MP0010678_abnormal_skin_adnexa	1.07880618
51	MP0004142_abnormal_muscle_tone	1.06450952
52	MP0009379_abnormal_foot_pigmentation	1.00907312
53	MP0006276_abnormal_autonomic_nervous	1.00267439
54	MP0010368_abnormal_lymphatic_system	1.00007836
55	MP0003119_abnormal_digestive_system	0.98314576
56	MP0001986_abnormal_taste_sensitivity	0.94707650
57	MP0000678_abnormal_parathyroid_gland	0.93836097
58	MP0002272_abnormal_nervous_system	0.90573344
59	MP0005085_abnormal_gallbladder_physiolo	0.85558467
60	MP0001672_abnormal_embryogenesis/_devel	0.84443311
61	MP0005380_embryogenesis_phenotype	0.84443311
62	MP0000350_abnormal_cell_proliferation	0.83745371
63	MP0003136_yellow_coat_color	0.82413352
64	MP0001664_abnormal_digestion	0.81618014
65	MP0002796_impaired_skin_barrier	0.78986250
66	MP0001666_abnormal_nutrient_absorption	0.75436139
67	MP0003868_abnormal_feces_composition	0.74992462
68	MP0000049_abnormal_middle_ear	0.72366469
69	MP0001502_abnormal_circadian_rhythm	0.70034243
70	MP0005551_abnormal_eye_electrophysiolog	0.68968243
71	MP0001324_abnormal_eye_pigmentation	0.64987194
72	MP0004957_abnormal_blastocyst_morpholog	0.61522144
73	MP0005501_abnormal_skin_physiology	0.60852456
74	MP0003941_abnormal_skin_development	0.60468703
75	MP0000015_abnormal_ear_pigmentation	0.56015988
76	MP0001963_abnormal_hearing_physiology	0.55559042
77	MP0002084_abnormal_developmental_patter	0.54587717
78	MP0005075_abnormal_melanosome_morpholog	0.53689459
79	MP0002089_abnormal_postnatal_growth/wei	0.51832098
80	MP0002127_abnormal_cardiovascular_syste	0.48487845
81	MP0002090_abnormal_vision	0.45230372
82	MP0005503_abnormal_tendon_morphology	0.42428198
83	MP0003935_abnormal_craniofacial_develop	0.42237184
84	MP0006138_congestive_heart_failure	0.42057263
85	MP0002751_abnormal_autonomic_nervous	0.41947471
86	MP0002928_abnormal_bile_duct	0.41429847
87	MP0005076_abnormal_cell_differentiation	0.41008042
88	MP0000377_abnormal_hair_follicle	0.40535988
89	MP0004043_abnormal_pH_regulation	0.39473663
90	MP0004381_abnormal_hair_follicle	0.39318170
91	MP0002085_abnormal_embryonic_tissue	0.38819837
92	MP0003959_abnormal_lean_body	0.35935402
93	MP0001697_abnormal_embryo_size	0.35755526
94	MP0002873_normal_phenotype	0.35362957
95	MP0001881_abnormal_mammary_gland	0.35258685
96	MP0002169_no_abnormal_phenotype	0.34905912
97	MP0008995_early_reproductive_senescence	0.34878712
98	MP0000383_abnormal_hair_follicle	0.34305621
99	MP0002735_abnormal_chemical_nociception	0.34058539
100	MP0003936_abnormal_reproductive_system	0.33918882

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Supernumerary spleens (HP:0009799)	6.50257804
2	Osteomalacia (HP:0002749)	5.23078978
3	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	5.06085386
4	Abnormality of abdominal situs (HP:0011620)	5.03632609
5	Abdominal situs inversus (HP:0003363)	5.03632609
6	Cholecystitis (HP:0001082)	5.02374754
7	Abnormal gallbladder physiology (HP:0012438)	5.02374754
8	Facial hemangioma (HP:0000329)	5.00768945
9	Male infertility (HP:0003251)	4.53738464
10	Lip pit (HP:0100267)	4.52190951
11	Oligodactyly (hands) (HP:0001180)	4.50339959
12	Hypophosphatemic rickets (HP:0004912)	4.44333693
13	Aplasia/Hypoplasia of the fovea (HP:0008060)	4.11991486
14	Hypoplasia of the fovea (HP:0007750)	4.11991486
15	Papillary thyroid carcinoma (HP:0002895)	4.11430078
16	Premature ovarian failure (HP:0008209)	4.06256859
17	Impulsivity (HP:0100710)	4.02140779
18	Azoospermia (HP:0000027)	3.96643543
19	Median cleft lip (HP:0000161)	3.91905009
20	Malnutrition (HP:0004395)	3.90372736
21	Septo-optic dysplasia (HP:0100842)	3.89326687
22	Anterior segment dysgenesis (HP:0007700)	3.78828217
23	Infertility (HP:0000789)	3.70199441
24	Short tibia (HP:0005736)	3.67418764
25	Abnormality of the fovea (HP:0000493)	3.59700156
26	Chromsome breakage (HP:0040012)	3.53113023
27	Absent septum pellucidum (HP:0001331)	3.51149426
28	Gonadotropin excess (HP:0000837)	3.48597477
29	Abnormality of the labia minora (HP:0012880)	3.46866215
30	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.42345808
31	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	3.33267863
32	Aplasia/Hypoplasia of the tibia (HP:0005772)	3.27168203
33	Oligodactyly (HP:0012165)	3.19600893
34	Wrist flexion contracture (HP:0001239)	3.11954704
35	Enlarged penis (HP:0000040)	3.09377020
36	Abnormality of the septum pellucidum (HP:0007375)	3.02208054
37	Capillary hemangiomas (HP:0005306)	3.00785297
38	Conjunctival telangiectasia (HP:0000524)	2.96092579
39	Abnormal spermatogenesis (HP:0008669)	2.94023250
40	Apathy (HP:0000741)	2.86318310
41	Urethral obstruction (HP:0000796)	2.84801288
42	Hypokinesia (HP:0002375)	2.84161972
43	Diminished motivation (HP:0000745)	2.80089665
44	Fair hair (HP:0002286)	2.78870526
45	Muscle stiffness (HP:0003552)	2.76002277
46	Spinal cord compression (HP:0002176)	2.68188219
47	Loss of speech (HP:0002371)	2.62462713
48	Aplasia/Hypoplasia of the macula (HP:0008059)	2.61376934
49	Metaphyseal irregularity (HP:0003025)	2.59770076
50	Stillbirth (HP:0003826)	2.59267638
51	Sensory axonal neuropathy (HP:0003390)	2.49820828
52	Proximal tubulopathy (HP:0000114)	2.48506949
53	Abnormality of the phalanges of the hallux (HP:0010057)	2.43232822
54	Skin pits (HP:0100276)	2.38899490
55	Generalized aminoaciduria (HP:0002909)	2.38840368
56	Aplasia/Hypoplasia affecting the retina (HP:0008061)	2.38438706
57	Truncal obesity (HP:0001956)	2.38050843
58	Intrahepatic cholestasis (HP:0001406)	2.36882752
59	Lower limb hyperreflexia (HP:0002395)	2.35093107
60	Aplasia of the musculature (HP:0100854)	2.31625155
61	Abnormality of the vasculature of the conjunctiva (HP:0008054)	2.31506124
62	Ankle contracture (HP:0006466)	2.31338246
63	Myokymia (HP:0002411)	2.30731856
64	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.28338417
65	Thyroid carcinoma (HP:0002890)	2.25997063
66	Abnormal lung lobation (HP:0002101)	2.23818603
67	Congenital sensorineural hearing impairment (HP:0008527)	2.22756781
68	Maternal diabetes (HP:0009800)	2.22714090
69	Abnormal biliary tract physiology (HP:0012439)	2.19080736
70	Bile duct proliferation (HP:0001408)	2.19080736
71	Bundle branch block (HP:0011710)	2.15141079
72	Anhidrosis (HP:0000970)	2.15028259
73	Abnormal ciliary motility (HP:0012262)	2.14492950
74	Dysdiadochokinesis (HP:0002075)	2.13324034
75	Abnormality of calcium-phosphate metabolism (HP:0100530)	2.12097739
76	Striae distensae (HP:0001065)	2.09619849
77	Heterotopia (HP:0002282)	2.02571856
78	Microglossia (HP:0000171)	2.01012296
79	Hydroureter (HP:0000072)	2.00090649
80	Nephroblastoma (Wilms tumor) (HP:0002667)	2.00038150
81	Generalized hypopigmentation of hair (HP:0011358)	1.97220183
82	Hip contracture (HP:0003273)	1.96822594
83	Posterior subcapsular cataract (HP:0007787)	1.95939950
84	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.94604885
85	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.93025257
86	Cranial hyperostosis (HP:0004437)	1.91827097
87	Rhinitis (HP:0012384)	1.91591747
88	Limb hypertonia (HP:0002509)	1.90424352
89	Abnormality of chromosome stability (HP:0003220)	1.90308118
90	Embryonal renal neoplasm (HP:0011794)	1.87114567
91	Abnormality of chromosome segregation (HP:0002916)	1.86749180
92	Bicornuate uterus (HP:0000813)	1.84542058
93	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.83237751
94	Rickets (HP:0002748)	1.80299203
95	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	1.80282493
96	Abnormality of monocarboxylic acid metabolism (HP:0010996)	1.79034549
97	Hypohidrosis (HP:0000966)	1.76119010
98	Steatorrhea (HP:0002570)	1.75261042
99	Duodenal stenosis (HP:0100867)	1.75186042
100	Small intestinal stenosis (HP:0012848)	1.75186042

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP3K9	6.68133529
2	ARAF	6.30195663
3	MAP3K13	6.19519883
4	STK24	3.27279964
5	BRAF	3.13536717
6	NEK6	3.08362611
7	MOS	2.83957456
8	MET	2.80904486
9	TTK	2.73417205
10	TAOK3	2.71565472
11	KSR2	2.23003288
12	CDK9	2.18508310
13	AURKA	2.10397439
14	RAF1	2.05559932
15	CDK12	1.84947371
16	CDC7	1.78788624
17	EIF2AK3	1.73310192
18	PRKCI	1.58923706
19	TNIK	1.46326117
20	NTRK2	1.43163285
21	CDK7	1.35226807
22	KSR1	1.34287852
23	STK3	1.28124055
24	ZAK	1.26024509
25	TRIM28	1.22516591
26	PLK1	1.22168257
27	CDK19	1.17349598
28	MELK	1.13911537
29	NEK9	1.04668847
30	BUB1	0.97100016
31	PIM1	0.96698432
32	NUAK1	0.95316056
33	MAP3K8	0.95031105
34	PTK2	0.84775602
35	NEK2	0.84167445
36	STK39	0.80218290
37	BRSK1	0.75556301
38	TIE1	0.74628478
39	PLK3	0.73179016
40	DMPK	0.71799998
41	CHEK1	0.71641952
42	MST4	0.71433898
43	TNK2	0.69954837
44	WNK1	0.69477764
45	BMPR1B	0.67720468
46	CDK2	0.63482767
47	CHEK2	0.62841357
48	MAPKAPK3	0.61911430
49	MARK3	0.61031361
50	NTRK3	0.59108958
51	AURKB	0.54914728
52	CSNK1G1	0.54492117
53	VRK1	0.54315340
54	CDK8	0.53460622
55	ACVR1B	0.52853984
56	BRSK2	0.51582454
57	PRKG1	0.50914337
58	ATM	0.48335484
59	PAK1	0.47459758
60	CSNK1D	0.46493209
61	TGFBR1	0.45187175
62	PKN1	0.44902998
63	CDK1	0.43387743
64	ATR	0.41329708
65	OXSR1	0.40157897
66	MAPK13	0.39931528
67	SRPK1	0.38272396
68	LRRK2	0.37053993
69	EEF2K	0.36713431
70	TLK1	0.34506438
71	MAP3K5	0.33148222
72	PRKCZ	0.31343338
73	CSNK1E	0.31223593
74	CDK5	0.31132002
75	PDK1	0.30513026
76	MTOR	0.30147029
77	CAMK2A	0.30065237
78	TYRO3	0.29430834
79	CSNK1G3	0.29419511
80	PLK4	0.29195378
81	MAP3K4	0.26999162
82	TRPM7	0.24600245
83	PRKACB	0.24010330
84	LMTK2	0.23864290
85	PBK	0.23706076
86	LATS1	0.23352446
87	PNCK	0.23296436
88	PRKACA	0.21730591
89	EGFR	0.21526280
90	MAPK1	0.19234424
91	AKT2	0.18779756
92	GSK3B	0.17416869
93	CSF1R	0.17371770
94	CHUK	0.17100537
95	MAP2K1	0.17060339
96	CDK11A	0.16216341
97	CSNK1G2	0.14404049
98	MAP3K1	0.13993358
99	PDPK1	0.13135131
100	CSNK1A1L	0.11935970

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Basal transcription factors_Homo sapiens_hsa03022	5.52611443
2	Cell cycle_Homo sapiens_hsa04110	4.51473298
3	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	4.15667197
4	Mismatch repair_Homo sapiens_hsa03430	4.03050798
5	Oocyte meiosis_Homo sapiens_hsa04114	3.52142007
6	Caffeine metabolism_Homo sapiens_hsa00232	3.29767415
7	RNA degradation_Homo sapiens_hsa03018	2.94698404
8	Base excision repair_Homo sapiens_hsa03410	2.90964682
9	Ovarian steroidogenesis_Homo sapiens_hsa04913	2.84263276
10	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.61554589
11	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	2.56370073
12	DNA replication_Homo sapiens_hsa03030	2.44200784
13	Nucleotide excision repair_Homo sapiens_hsa03420	2.39974259
14	Fanconi anemia pathway_Homo sapiens_hsa03460	2.25133874
15	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.23985710
16	Homologous recombination_Homo sapiens_hsa03440	2.19556802
17	Olfactory transduction_Homo sapiens_hsa04740	2.07566382
18	Cysteine and methionine metabolism_Homo sapiens_hsa00270	2.01701674
19	RNA transport_Homo sapiens_hsa03013	1.86523568
20	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.81405135
21	Circadian rhythm_Homo sapiens_hsa04710	1.78492774
22	p53 signaling pathway_Homo sapiens_hsa04115	1.65465154
23	Folate biosynthesis_Homo sapiens_hsa00790	1.62253263
24	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.43451621
25	Thyroid cancer_Homo sapiens_hsa05216	1.32242931
26	Gap junction_Homo sapiens_hsa04540	1.30247237
27	Phototransduction_Homo sapiens_hsa04744	1.22022181
28	RNA polymerase_Homo sapiens_hsa03020	1.20003669
29	mRNA surveillance pathway_Homo sapiens_hsa03015	1.13366528
30	Nicotine addiction_Homo sapiens_hsa05033	1.09718244
31	ABC transporters_Homo sapiens_hsa02010	1.00849838
32	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.98338275
33	Bile secretion_Homo sapiens_hsa04976	0.93011300
34	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.83952497
35	Morphine addiction_Homo sapiens_hsa05032	0.83235086
36	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.82102294
37	Fatty acid elongation_Homo sapiens_hsa00062	0.80940794
38	GABAergic synapse_Homo sapiens_hsa04727	0.76317767
39	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.69305652
40	Taste transduction_Homo sapiens_hsa04742	0.65352075
41	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.64616896
42	Viral carcinogenesis_Homo sapiens_hsa05203	0.63791577
43	mTOR signaling pathway_Homo sapiens_hsa04150	0.63484120
44	Long-term depression_Homo sapiens_hsa04730	0.62223588
45	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.61610026
46	Serotonergic synapse_Homo sapiens_hsa04726	0.56417696
47	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.54839434
48	Purine metabolism_Homo sapiens_hsa00230	0.54027099
49	FoxO signaling pathway_Homo sapiens_hsa04068	0.51548678
50	Adherens junction_Homo sapiens_hsa04520	0.48895600
51	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.47906688
52	Small cell lung cancer_Homo sapiens_hsa05222	0.47730578
53	Herpes simplex infection_Homo sapiens_hsa05168	0.45006142
54	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.44654362
55	HTLV-I infection_Homo sapiens_hsa05166	0.43663436
56	MicroRNAs in cancer_Homo sapiens_hsa05206	0.42511115
57	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.41062122
58	ErbB signaling pathway_Homo sapiens_hsa04012	0.39739263
59	Regulation of autophagy_Homo sapiens_hsa04140	0.38017771
60	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.33437947
61	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.27196281
62	Ras signaling pathway_Homo sapiens_hsa04014	0.26830207
63	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.26377598
64	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.25977591
65	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.23383376
66	Hippo signaling pathway_Homo sapiens_hsa04390	0.21764372
67	Wnt signaling pathway_Homo sapiens_hsa04310	0.19604922
68	Endometrial cancer_Homo sapiens_hsa05213	0.18592469
69	cAMP signaling pathway_Homo sapiens_hsa04024	0.17709061
70	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.17525005
71	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.17455238
72	Protein digestion and absorption_Homo sapiens_hsa04974	0.17302526
73	Non-homologous end-joining_Homo sapiens_hsa03450	0.16727142
74	Linoleic acid metabolism_Homo sapiens_hsa00591	0.14864625
75	Arginine biosynthesis_Homo sapiens_hsa00220	0.14369190
76	Cholinergic synapse_Homo sapiens_hsa04725	0.14277252
77	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.14254983
78	Pyrimidine metabolism_Homo sapiens_hsa00240	0.14033510
79	Huntingtons disease_Homo sapiens_hsa05016	0.13861376
80	Arginine and proline metabolism_Homo sapiens_hsa00330	0.13417094
81	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.12564778
82	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.12456974
83	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.12245512
84	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.11745515
85	Spliceosome_Homo sapiens_hsa03040	0.11461989
86	Long-term potentiation_Homo sapiens_hsa04720	0.10013709
87	Propanoate metabolism_Homo sapiens_hsa00640	0.09445310
88	MAPK signaling pathway_Homo sapiens_hsa04010	0.09331451
89	Colorectal cancer_Homo sapiens_hsa05210	0.08741066
90	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.08590340
91	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.08130262
92	Hepatitis B_Homo sapiens_hsa05161	0.08122668
93	Renal cell carcinoma_Homo sapiens_hsa05211	0.07252690
94	Circadian entrainment_Homo sapiens_hsa04713	0.06350121
95	Non-small cell lung cancer_Homo sapiens_hsa05223	0.05952864
96	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.05886279
97	Glutamatergic synapse_Homo sapiens_hsa04724	0.05736917
98	Phagosome_Homo sapiens_hsa04145	0.04950361
99	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.04609629
100	Tight junction_Homo sapiens_hsa04530	0.04111028

EBLN1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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