ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	retinal cone cell development (GO:0046549)	5.27887159
2	protein polyglutamylation (GO:0018095)	4.58009097
3	fucose catabolic process (GO:0019317)	4.20543467
4	L-fucose metabolic process (GO:0042354)	4.20543467
5	L-fucose catabolic process (GO:0042355)	4.20543467
6	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	4.15403888
7	negative regulation of translation, ncRNA-mediated (GO:0040033)	4.15403888
8	regulation of translation, ncRNA-mediated (GO:0045974)	4.15403888
9	retinal rod cell development (GO:0046548)	3.88184339
10	synapsis (GO:0007129)	3.86562562
11	histone H3-K4 trimethylation (GO:0080182)	3.77117651
12	negative regulation of cell killing (GO:0031342)	3.70026801
13	negative regulation of leukocyte mediated cytotoxicity (GO:0001911)	3.70026801
14	phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)	3.52866091
15	DNA integration (GO:0015074)	3.51863768
16	histone exchange (GO:0043486)	3.50804945
17	seminiferous tubule development (GO:0072520)	3.45429221
18	endoderm formation (GO:0001706)	3.39258708
19	piRNA metabolic process (GO:0034587)	3.32865683
20	myelin assembly (GO:0032288)	3.25480800
21	neural tube formation (GO:0001841)	3.22213039
22	positive regulation of granulocyte differentiation (GO:0030854)	3.13308028
23	DNA demethylation (GO:0080111)	3.11701142
24	protein K63-linked deubiquitination (GO:0070536)	3.10237679
25	CENP-A containing nucleosome assembly (GO:0034080)	3.09857458
26	histone H3-K9 methylation (GO:0051567)	3.08722993
27	interferon-gamma production (GO:0032609)	3.08701548
28	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.08529942
29	centriole replication (GO:0007099)	3.06519248
30	nucleotide transmembrane transport (GO:1901679)	3.04814138
31	regulation of establishment of cell polarity (GO:2000114)	3.04361861
32	histone H2A acetylation (GO:0043968)	3.03029806
33	chromatin remodeling at centromere (GO:0031055)	3.02839786
34	positive regulation of T-helper 1 type immune response (GO:0002827)	2.98863008
35	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	2.97816009
36	axoneme assembly (GO:0035082)	2.95973631
37	valine metabolic process (GO:0006573)	2.95071675
38	monoubiquitinated protein deubiquitination (GO:0035520)	2.88868098
39	negative regulation of neurological system process (GO:0031645)	2.85801495
40	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.85450466
41	peptidyl-lysine trimethylation (GO:0018023)	2.82875742
42	protein K11-linked deubiquitination (GO:0035871)	2.82056142
43	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.81130850
44	regulation of mitotic spindle checkpoint (GO:1903504)	2.81130850
45	histone H3-K9 modification (GO:0061647)	2.80084994
46	regulation of telomere maintenance (GO:0032204)	2.80037050
47	somite development (GO:0061053)	2.79965631
48	behavioral response to nicotine (GO:0035095)	2.79636676
49	detection of light stimulus involved in visual perception (GO:0050908)	2.78152678
50	detection of light stimulus involved in sensory perception (GO:0050962)	2.78152678
51	kidney morphogenesis (GO:0060993)	2.73233883
52	regulation of gamma-delta T cell activation (GO:0046643)	2.71158279
53	histone mRNA catabolic process (GO:0071044)	2.70434081
54	DNA deamination (GO:0045006)	2.66250214
55	S-adenosylmethionine metabolic process (GO:0046500)	2.64658063
56	regulation of gamma-delta T cell differentiation (GO:0045586)	2.63061214
57	resolution of meiotic recombination intermediates (GO:0000712)	2.62803506
58	negative regulation of T cell mediated immunity (GO:0002710)	2.62512882
59	DNA dealkylation (GO:0035510)	2.61570484
60	gene silencing by RNA (GO:0031047)	2.60630520
61	parturition (GO:0007567)	2.60340013
62	positive regulation of glycoprotein biosynthetic process (GO:0010560)	2.59415359
63	cellular response to interleukin-15 (GO:0071350)	2.59270920
64	pyrimidine dimer repair (GO:0006290)	2.58699868
65	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)	2.58276292
66	regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)	2.58276292
67	otic vesicle formation (GO:0030916)	2.57291931
68	tyrosine phosphorylation of STAT protein (GO:0007260)	2.56550737
69	mitotic sister chromatid cohesion (GO:0007064)	2.56312528
70	recombinational repair (GO:0000725)	2.56255925
71	positive regulation of mRNA catabolic process (GO:0061014)	2.55843066
72	regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)	2.55594643
73	positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)	2.55594643
74	mitotic metaphase plate congression (GO:0007080)	2.53526780
75	regulation of mesenchymal cell apoptotic process (GO:2001053)	2.53303202
76	regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)	2.53010613
77	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO	2.53010613
78	negative regulation of interleukin-1 beta production (GO:0032691)	2.51560385
79	double-strand break repair via homologous recombination (GO:0000724)	2.51404214
80	positive regulation of gamma-delta T cell activation (GO:0046645)	2.50771231
81	retina layer formation (GO:0010842)	2.49363670
82	photoreceptor cell development (GO:0042461)	2.48769954
83	activated T cell proliferation (GO:0050798)	2.47866826
84	regulation of male gonad development (GO:2000018)	2.47798198
85	protein prenylation (GO:0018342)	2.47148073
86	prenylation (GO:0097354)	2.47148073
87	regulation of pigment cell differentiation (GO:0050932)	2.45665643
88	male meiosis (GO:0007140)	2.45640116
89	DNA methylation involved in gamete generation (GO:0043046)	2.44416928
90	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339	2.43800529
91	Golgi to endosome transport (GO:0006895)	2.43128115
92	peptidyl-lysine methylation (GO:0018022)	2.42542752
93	reciprocal DNA recombination (GO:0035825)	2.42025107
94	reciprocal meiotic recombination (GO:0007131)	2.42025107
95	negative T cell selection (GO:0043383)	2.40545533
96	establishment of protein localization to Golgi (GO:0072600)	2.39807649
97	rRNA catabolic process (GO:0016075)	2.39508298
98	regulation of interleukin-6 biosynthetic process (GO:0045408)	2.38915500
99	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.36822084
100	regulation of protein glycosylation (GO:0060049)	2.35594856

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.21421005
2	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.74394981
3	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.67956073
4	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.62617117
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.52590638
6	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.41819015
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.38651684
8	VDR_22108803_ChIP-Seq_LS180_Human	2.37735041
9	TP63_19390658_ChIP-ChIP_HaCaT_Human	2.36248134
10	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.35526437
11	EWS_26573619_Chip-Seq_HEK293_Human	2.30724886
12	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.29377344
13	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.20370342
14	ER_23166858_ChIP-Seq_MCF-7_Human	2.06688218
15	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.03437009
16	TAF15_26573619_Chip-Seq_HEK293_Human	2.00029003
17	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.95846513
18	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.94861862
19	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.92662502
20	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.92243731
21	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.90020985
22	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.89695445
23	GBX2_23144817_ChIP-Seq_PC3_Human	1.88936528
24	P300_19829295_ChIP-Seq_ESCs_Human	1.82301293
25	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.81818191
26	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.81322292
27	FUS_26573619_Chip-Seq_HEK293_Human	1.77993248
28	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.75138023
29	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.73805871
30	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.69212494
31	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.65837661
32	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.62977828
33	IRF1_19129219_ChIP-ChIP_H3396_Human	1.55738807
34	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.55598074
35	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.55374961
36	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.55160956
37	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.52622339
38	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.51561586
39	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.51561586
40	CBP_20019798_ChIP-Seq_JUKART_Human	1.50386759
41	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.50386759
42	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.49048527
43	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.48033235
44	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.48016797
45	BCAT_22108803_ChIP-Seq_LS180_Human	1.47983388
46	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.46277811
47	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.45036932
48	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.44792466
49	EZH2_22144423_ChIP-Seq_EOC_Human	1.42654116
50	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.42534458
51	SMAD4_21799915_ChIP-Seq_A2780_Human	1.40258482
52	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.40106775
53	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.39647657
54	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.39391255
55	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.39024426
56	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.38376471
57	VDR_23849224_ChIP-Seq_CD4+_Human	1.37211169
58	ELK1_19687146_ChIP-ChIP_HELA_Human	1.36583736
59	STAT3_23295773_ChIP-Seq_U87_Human	1.36320449
60	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.33960670
61	TCF4_23295773_ChIP-Seq_U87_Human	1.33468664
62	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.31651843
63	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.29253757
64	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.29133977
65	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.28538951
66	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.27950616
67	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.26035756
68	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.25725886
69	SOX2_19829295_ChIP-Seq_ESCs_Human	1.23659184
70	NANOG_19829295_ChIP-Seq_ESCs_Human	1.23659184
71	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.23415474
72	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.21761208
73	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.21318243
74	P53_22387025_ChIP-Seq_ESCs_Mouse	1.21293959
75	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.19788766
76	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.19424216
77	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.18542568
78	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.18459559
79	MYC_18940864_ChIP-ChIP_HL60_Human	1.18323467
80	RNF2_27304074_Chip-Seq_NSC_Mouse	1.17590375
81	P300_18555785_Chip-Seq_ESCs_Mouse	1.17111101
82	TP53_22573176_ChIP-Seq_HFKS_Human	1.16487092
83	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.16475638
84	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.16350332
85	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.15615141
86	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.15349523
87	AR_21572438_ChIP-Seq_LNCaP_Human	1.14573383
88	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.14133886
89	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.13527698
90	VDR_24787735_ChIP-Seq_THP-1_Human	1.12618295
91	TCF4_22108803_ChIP-Seq_LS180_Human	1.11851562
92	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.10877690
93	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.10783960
94	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.10597593
95	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.10048279
96	RUNX2_22187159_ChIP-Seq_PCA_Human	1.09214764
97	CDX2_22108803_ChIP-Seq_LS180_Human	1.08174868
98	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.07282431
99	NMYC_18555785_Chip-Seq_ESCs_Mouse	1.07196902
100	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.06873591

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	5.65997602
2	MP0003787_abnormal_imprinting	4.92924062
3	MP0005075_abnormal_melanosome_morpholog	3.16444655
4	MP0008995_early_reproductive_senescence	3.04242777
5	MP0006292_abnormal_olfactory_placode	2.63029229
6	MP0003890_abnormal_embryonic-extraembry	2.59412001
7	MP0003646_muscle_fatigue	2.43221605
8	MP0000569_abnormal_digit_pigmentation	2.35603608
9	MP0000372_irregular_coat_pigmentation	2.24608288
10	MP0002638_abnormal_pupillary_reflex	2.20766751
11	MP0001919_abnormal_reproductive_system	2.19040691
12	MP0003786_premature_aging	2.13502322
13	MP0002102_abnormal_ear_morphology	2.09214970
14	MP0003195_calcinosis	2.05425907
15	MP0008057_abnormal_DNA_replication	1.97167610
16	MP0003121_genomic_imprinting	1.86833388
17	MP0003828_pulmonary_edema	1.77720531
18	MP0005389_reproductive_system_phenotype	1.67037905
19	MP0005551_abnormal_eye_electrophysiolog	1.66245890
20	MP0001986_abnormal_taste_sensitivity	1.63334167
21	MP0003763_abnormal_thymus_physiology	1.61831793
22	MP0002254_reproductive_system_inflammat	1.58716805
23	MP0006072_abnormal_retinal_apoptosis	1.58608452
24	MP0003045_fibrosis	1.51683663
25	MP0002876_abnormal_thyroid_physiology	1.50276345
26	MP0004142_abnormal_muscle_tone	1.49048629
27	MP0005084_abnormal_gallbladder_morpholo	1.45227380
28	MP0005671_abnormal_response_to	1.45080531
29	MP0001835_abnormal_antigen_presentation	1.44666407
30	MP0003878_abnormal_ear_physiology	1.44359232
31	MP0005377_hearing/vestibular/ear_phenot	1.44359232
32	MP0008058_abnormal_DNA_repair	1.37585920
33	MP0002009_preneoplasia	1.33940333
34	MP0000427_abnormal_hair_cycle	1.33489768
35	MP0001873_stomach_inflammation	1.31753903
36	MP0001800_abnormal_humoral_immune	1.31484008
37	MP0005310_abnormal_salivary_gland	1.30974345
38	MP0002938_white_spotting	1.27079675
39	MP0001790_abnormal_immune_system	1.25866888
40	MP0005387_immune_system_phenotype	1.25866888
41	MP0005253_abnormal_eye_physiology	1.23842038
42	MP0005174_abnormal_tail_pigmentation	1.20965965
43	MP0000383_abnormal_hair_follicle	1.19774670
44	MP0001188_hyperpigmentation	1.16657565
45	MP0003252_abnormal_bile_duct	1.12391617
46	MP0000015_abnormal_ear_pigmentation	1.11575018
47	MP0003943_abnormal_hepatobiliary_system	1.10196218
48	MP0004885_abnormal_endolymph	1.07312215
49	MP0009785_altered_susceptibility_to	1.05546959
50	MP0001929_abnormal_gametogenesis	1.04488246
51	MP0002277_abnormal_respiratory_mucosa	1.02985795
52	MP0005647_abnormal_sex_gland	1.02236799
53	MP0002405_respiratory_system_inflammati	1.01979141
54	MP0001501_abnormal_sleep_pattern	1.00245457
55	MP0002210_abnormal_sex_determination	0.97194765
56	MP0005000_abnormal_immune_tolerance	0.96628798
57	MP0002723_abnormal_immune_serum	0.96042018
58	MP0003698_abnormal_male_reproductive	0.94552234
59	MP0008789_abnormal_olfactory_epithelium	0.92968322
60	MP0002095_abnormal_skin_pigmentation	0.92253564
61	MP0003567_abnormal_fetal_cardiomyocyte	0.91775185
62	MP0001440_abnormal_grooming_behavior	0.91170138
63	MP0006276_abnormal_autonomic_nervous	0.91077259
64	MP0000631_abnormal_neuroendocrine_gland	0.90544472
65	MP0001145_abnormal_male_reproductive	0.89032330
66	MP0001119_abnormal_female_reproductive	0.86744181
67	MP0000653_abnormal_sex_gland	0.86671487
68	MP0002148_abnormal_hypersensitivity_rea	0.85638845
69	MP0005410_abnormal_fertilization	0.85022635
70	MP0001764_abnormal_homeostasis	0.84817169
71	MP0002420_abnormal_adaptive_immunity	0.81662667
72	MP0000470_abnormal_stomach_morphology	0.81618182
73	MP0003936_abnormal_reproductive_system	0.79587038
74	MP0002168_other_aberrant_phenotype	0.79027797
75	MP0000685_abnormal_immune_system	0.78232584
76	MP0010678_abnormal_skin_adnexa	0.76611752
77	MP0000371_diluted_coat_color	0.76522396
78	MP0009697_abnormal_copulation	0.75938452
79	MP0005266_abnormal_metabolism	0.75761428
80	MP0003724_increased_susceptibility_to	0.75671975
81	MP0001819_abnormal_immune_cell	0.75023446
82	MP0000689_abnormal_spleen_morphology	0.74796680
83	MP0009764_decreased_sensitivity_to	0.73273726
84	MP0008872_abnormal_physiological_respon	0.72014494
85	MP0002452_abnormal_antigen_presenting	0.71189109
86	MP0000647_abnormal_sebaceous_gland	0.70557872
87	MP0005195_abnormal_posterior_eye	0.70366195
88	MP0005360_urolithiasis	0.69973594
89	MP0003283_abnormal_digestive_organ	0.68021278
90	MP0005646_abnormal_pituitary_gland	0.67516094
91	MP0001529_abnormal_vocalization	0.66162453
92	MP0002332_abnormal_exercise_endurance	0.65328882
93	MP0002166_altered_tumor_susceptibility	0.64114912
94	MP0001191_abnormal_skin_condition	0.64099994
95	MP0008961_abnormal_basal_metabolism	0.63595756
96	MP0001286_abnormal_eye_development	0.63387846
97	MP0002751_abnormal_autonomic_nervous	0.63271789
98	MP0002160_abnormal_reproductive_system	0.62583394
99	MP0009379_abnormal_foot_pigmentation	0.62118857
100	MP0002398_abnormal_bone_marrow	0.61708862

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	4.09658183
2	Volvulus (HP:0002580)	3.86167050
3	Amyotrophic lateral sclerosis (HP:0007354)	3.31440443
4	Attenuation of retinal blood vessels (HP:0007843)	3.22966337
5	True hermaphroditism (HP:0010459)	3.21600502
6	Abnormality of midbrain morphology (HP:0002418)	3.14502624
7	Molar tooth sign on MRI (HP:0002419)	3.14502624
8	Recurrent cutaneous fungal infections (HP:0011370)	3.14447625
9	Chronic mucocutaneous candidiasis (HP:0002728)	3.14447625
10	Chronic hepatic failure (HP:0100626)	3.13533585
11	Nephronophthisis (HP:0000090)	3.10778586
12	Concave nail (HP:0001598)	3.10322874
13	Stomatitis (HP:0010280)	3.04244135
14	Protruding tongue (HP:0010808)	3.02853924
15	Aplasia/Hypoplasia of the sternum (HP:0006714)	2.99975712
16	Pancreatic cysts (HP:0001737)	2.97392975
17	Oligodactyly (hands) (HP:0001180)	2.85157558
18	Abnormality of the renal medulla (HP:0100957)	2.80078289
19	IgG deficiency (HP:0004315)	2.77029239
20	Abnormality of DNA repair (HP:0003254)	2.71828653
21	Abolished electroretinogram (ERG) (HP:0000550)	2.71256591
22	Adactyly (HP:0009776)	2.67438953
23	Hyperventilation (HP:0002883)	2.66294455
24	Clumsiness (HP:0002312)	2.62116965
25	Hypoplastic iliac wings (HP:0002866)	2.60498453
26	Pancreatic fibrosis (HP:0100732)	2.56055202
27	Abnormality of the renal cortex (HP:0011035)	2.50673886
28	Broad alveolar ridges (HP:0000187)	2.48787504
29	Facial diplegia (HP:0001349)	2.42177013
30	Hypochromic microcytic anemia (HP:0004840)	2.36729493
31	Tubulointerstitial nephritis (HP:0001970)	2.36636011
32	Male pseudohermaphroditism (HP:0000037)	2.34582409
33	Abnormal rod and cone electroretinograms (HP:0008323)	2.34468406
34	Increased hepatocellular lipid droplets (HP:0006565)	2.32831060
35	Renal cortical cysts (HP:0000803)	2.23525679
36	Anencephaly (HP:0002323)	2.22811155
37	Gonadotropin excess (HP:0000837)	2.17523685
38	Retrobulbar optic neuritis (HP:0100654)	2.08762365
39	Optic neuritis (HP:0100653)	2.08762365
40	Lipid accumulation in hepatocytes (HP:0006561)	2.08703214
41	Bile duct proliferation (HP:0001408)	2.08579443
42	Abnormal biliary tract physiology (HP:0012439)	2.08579443
43	Gaze-evoked nystagmus (HP:0000640)	2.08068066
44	Distal arthrogryposis (HP:0005684)	2.07956423
45	Congenital hepatic fibrosis (HP:0002612)	2.07687785
46	Pachygyria (HP:0001302)	2.07687653
47	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.01111806
48	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.01111806
49	Absent thumb (HP:0009777)	1.99546468
50	Visual hallucinations (HP:0002367)	1.97679212
51	Gonadal dysgenesis (HP:0000133)	1.97190516
52	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.96106625
53	Keratoconjunctivitis (HP:0001096)	1.92710418
54	Broad-based gait (HP:0002136)	1.92608897
55	Atrophy/Degeneration involving motor neurons (HP:0007373)	1.91647137
56	Prostate neoplasm (HP:0100787)	1.89117378
57	Focal seizures (HP:0007359)	1.85984371
58	Elevated erythrocyte sedimentation rate (HP:0003565)	1.85631991
59	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.83599970
60	Stomach cancer (HP:0012126)	1.80632109
61	Sclerocornea (HP:0000647)	1.79782385
62	Mitochondrial inheritance (HP:0001427)	1.78261240
63	Abnormality of male internal genitalia (HP:0000022)	1.77915092
64	Febrile seizures (HP:0002373)	1.76063739
65	Abnormal hair whorl (HP:0010721)	1.76050837
66	Abnormality of the prostate (HP:0008775)	1.75907236
67	Progressive inability to walk (HP:0002505)	1.75517733
68	Azoospermia (HP:0000027)	1.74584045
69	Dry hair (HP:0011359)	1.73194892
70	Dyskinesia (HP:0100660)	1.72138751
71	Genetic anticipation (HP:0003743)	1.71976779
72	Abnormal pancreas size (HP:0012094)	1.71815378
73	Bony spicule pigmentary retinopathy (HP:0007737)	1.70476310
74	Peripheral hypomyelination (HP:0007182)	1.69827041
75	Abnormality of T cell number (HP:0011839)	1.69507912
76	Absent speech (HP:0001344)	1.68982587
77	Oligodactyly (HP:0012165)	1.68639125
78	T lymphocytopenia (HP:0005403)	1.68454180
79	Small hand (HP:0200055)	1.67791604
80	Acute necrotizing encephalopathy (HP:0006965)	1.67612145
81	Asplenia (HP:0001746)	1.67280929
82	Acute myeloid leukemia (HP:0004808)	1.65242238
83	Embryonal renal neoplasm (HP:0011794)	1.64965252
84	Fibular hypoplasia (HP:0003038)	1.64960069
85	Increased CSF lactate (HP:0002490)	1.64241229
86	Medial flaring of the eyebrow (HP:0010747)	1.62539343
87	Nephroblastoma (Wilms tumor) (HP:0002667)	1.62377401
88	Glossoptosis (HP:0000162)	1.62155474
89	Diastasis recti (HP:0001540)	1.62065280
90	Renal Fanconi syndrome (HP:0001994)	1.61502631
91	Cupped ear (HP:0000378)	1.61279915
92	Abnormality of the pons (HP:0007361)	1.58985469
93	Dialeptic seizures (HP:0011146)	1.58555974
94	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.58297135
95	Narrow forehead (HP:0000341)	1.58189133
96	Hypoplasia of the pons (HP:0012110)	1.56351191
97	Progressive macrocephaly (HP:0004481)	1.55787209
98	Short tibia (HP:0005736)	1.55750276
99	Abnormality of macular pigmentation (HP:0008002)	1.55363618
100	Pendular nystagmus (HP:0012043)	1.54737118

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ACVR1B	6.35135912
2	FRK	3.56183835
3	NUAK1	3.43482349
4	TXK	3.24776703
5	TLK1	2.80220032
6	BMPR1B	2.73186133
7	STK38L	2.26865653
8	BRSK2	2.25094577
9	WEE1	1.85322334
10	ZAK	1.78132779
11	EIF2AK3	1.63950774
12	MAP3K14	1.60749759
13	GRK1	1.59921594
14	TEC	1.56331497
15	ADRBK2	1.51540667
16	MKNK2	1.47750557
17	CASK	1.46293547
18	SRPK1	1.38097908
19	TNIK	1.27562811
20	PINK1	1.21686349
21	MAPK13	1.18435979
22	MUSK	1.17246595
23	WNK3	1.17218881
24	IKBKE	1.14726089
25	SIK3	1.13353026
26	AKT3	1.13213240
27	WNK1	1.10408669
28	NLK	1.10131157
29	TRIM28	1.06934908
30	ITK	1.06167924
31	VRK1	1.01230901
32	STK3	0.96789600
33	DYRK1A	0.96473585
34	CSNK1G2	0.93613526
35	TNK2	0.91998938
36	MAP2K2	0.91230243
37	SYK	0.86583720
38	MKNK1	0.85192934
39	CHUK	0.83849168
40	STK11	0.82507009
41	BRD4	0.80538822
42	PIK3CG	0.79012767
43	IRAK4	0.78267728
44	VRK2	0.77207677
45	MARK3	0.76140323
46	PIM1	0.75990365
47	OXSR1	0.75592599
48	MAP4K1	0.74882092
49	IKBKB	0.74569953
50	PRKCQ	0.74086776
51	TAOK1	0.72862117
52	CDK4	0.72855795
53	CDK19	0.72676128
54	IRAK1	0.72112416
55	TGFBR1	0.71175016
56	SGK2	0.70472223
57	STK24	0.70005830
58	BTK	0.68620447
59	DAPK2	0.65223764
60	MAP2K6	0.62433004
61	CSNK1G1	0.59134310
62	PNCK	0.58383780
63	FES	0.56861932
64	PAK3	0.56494357
65	MST4	0.55762280
66	CDK3	0.55435925
67	INSRR	0.54367355
68	TAOK3	0.54181090
69	WNK4	0.52723562
70	FLT3	0.50223895
71	KIT	0.49026870
72	TRPM7	0.47987807
73	MELK	0.46562852
74	EIF2AK2	0.46426261
75	STK4	0.45656976
76	BLK	0.44539084
77	CSNK1D	0.43880883
78	TGFBR2	0.43777677
79	YES1	0.41881311
80	RPS6KA4	0.41679438
81	LYN	0.41480238
82	PASK	0.40740637
83	RPS6KA5	0.40679747
84	KSR1	0.40023189
85	MAP3K13	0.39297863
86	PLK1	0.39170155
87	PTK2B	0.38698879
88	LCK	0.37292983
89	ERBB3	0.37087410
90	ATM	0.36959130
91	MAP2K1	0.36806605
92	MAP4K2	0.36738104
93	PRKG1	0.36096339
94	ADRBK1	0.36019928
95	MAP3K4	0.35822999
96	GSK3A	0.34968749
97	ATR	0.34752813
98	ERBB2	0.34111451
99	CAMK1	0.33297666
100	PRKCE	0.32995615

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.64796873
2	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	2.63794674
3	Homologous recombination_Homo sapiens_hsa03440	2.46605517
4	Allograft rejection_Homo sapiens_hsa05330	2.45841508
5	Graft-versus-host disease_Homo sapiens_hsa05332	2.42921345
6	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.29440722
7	Asthma_Homo sapiens_hsa05310	2.25034030
8	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.18162795
9	Primary immunodeficiency_Homo sapiens_hsa05340	2.08398412
10	Type I diabetes mellitus_Homo sapiens_hsa04940	2.07525887
11	Phototransduction_Homo sapiens_hsa04744	2.07078278
12	RNA degradation_Homo sapiens_hsa03018	2.02847568
13	Non-homologous end-joining_Homo sapiens_hsa03450	1.95412781
14	Nucleotide excision repair_Homo sapiens_hsa03420	1.93344835
15	Circadian rhythm_Homo sapiens_hsa04710	1.88678911
16	RNA polymerase_Homo sapiens_hsa03020	1.87213691
17	Linoleic acid metabolism_Homo sapiens_hsa00591	1.80431215
18	Basal transcription factors_Homo sapiens_hsa03022	1.77238744
19	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.68035576
20	Regulation of autophagy_Homo sapiens_hsa04140	1.67778606
21	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.62597934
22	Nitrogen metabolism_Homo sapiens_hsa00910	1.61273871
23	Proteasome_Homo sapiens_hsa03050	1.56523194
24	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.51919714
25	Propanoate metabolism_Homo sapiens_hsa00640	1.51684826
26	Protein export_Homo sapiens_hsa03060	1.46160085
27	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.44558829
28	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.36359340
29	Fanconi anemia pathway_Homo sapiens_hsa03460	1.34017037
30	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.25320969
31	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.21882384
32	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.12289472
33	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.10651752
34	Antigen processing and presentation_Homo sapiens_hsa04612	1.10570412
35	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.09056961
36	Jak-STAT signaling pathway_Homo sapiens_hsa04630	1.08859043
37	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.07851060
38	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.06848969
39	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.05212012
40	Mismatch repair_Homo sapiens_hsa03430	1.02145927
41	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.01317499
42	Selenocompound metabolism_Homo sapiens_hsa00450	1.00140910
43	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.99564765
44	Ether lipid metabolism_Homo sapiens_hsa00565	0.98489339
45	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.92627849
46	Peroxisome_Homo sapiens_hsa04146	0.91825512
47	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.91743625
48	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.91548174
49	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.91206831
50	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.90957865
51	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.90634280
52	Nicotine addiction_Homo sapiens_hsa05033	0.90063988
53	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.87979908
54	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.87584143
55	ABC transporters_Homo sapiens_hsa02010	0.87541332
56	Leishmaniasis_Homo sapiens_hsa05140	0.82833663
57	RNA transport_Homo sapiens_hsa03013	0.81692507
58	Measles_Homo sapiens_hsa05162	0.80600965
59	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.75046607
60	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.73278392
61	Taste transduction_Homo sapiens_hsa04742	0.71885191
62	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.71872403
63	Rheumatoid arthritis_Homo sapiens_hsa05323	0.70691867
64	African trypanosomiasis_Homo sapiens_hsa05143	0.69850674
65	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.64385594
66	Herpes simplex infection_Homo sapiens_hsa05168	0.62868723
67	Olfactory transduction_Homo sapiens_hsa04740	0.62348455
68	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.62181101
69	Steroid biosynthesis_Homo sapiens_hsa00100	0.59589780
70	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.58711257
71	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.57510027
72	Butanoate metabolism_Homo sapiens_hsa00650	0.57035161
73	Oxidative phosphorylation_Homo sapiens_hsa00190	0.56957758
74	FoxO signaling pathway_Homo sapiens_hsa04068	0.55365098
75	Spliceosome_Homo sapiens_hsa03040	0.54094402
76	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.53704004
77	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.52982089
78	mRNA surveillance pathway_Homo sapiens_hsa03015	0.52466591
79	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.51708615
80	Huntingtons disease_Homo sapiens_hsa05016	0.49048373
81	Insulin secretion_Homo sapiens_hsa04911	0.46720629
82	Long-term depression_Homo sapiens_hsa04730	0.46013653
83	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.43610806
84	p53 signaling pathway_Homo sapiens_hsa04115	0.42728476
85	Tuberculosis_Homo sapiens_hsa05152	0.41433632
86	Chemical carcinogenesis_Homo sapiens_hsa05204	0.40998892
87	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.38587133
88	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.37616773
89	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.37532690
90	Serotonergic synapse_Homo sapiens_hsa04726	0.37520357
91	Glycerolipid metabolism_Homo sapiens_hsa00561	0.37432948
92	Retinol metabolism_Homo sapiens_hsa00830	0.37010019
93	Lysine degradation_Homo sapiens_hsa00310	0.36504119
94	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.35205722
95	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.33657549
96	Viral myocarditis_Homo sapiens_hsa05416	0.33402669
97	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.31101034
98	Prostate cancer_Homo sapiens_hsa05215	0.30998759
99	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.30650260
100	Basal cell carcinoma_Homo sapiens_hsa05217	0.30156082

EBLN2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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