EBP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an integral membrane protein of the endoplasmic reticulum. It is a high affinity binding protein for the antiischemic phenylalkylamine Ca2+ antagonist [3H]emopamil and the photoaffinity label [3H]azidopamil. It is similar to sigma receptors and may be a member of a superfamily of high affinity drug-binding proteins in the endoplasmic reticulum of different tissues. This protein shares structural features with bacterial and eukaryontic drug transporting proteins. It has four putative transmembrane segments and contains two conserved glutamate residues which may be involved in the transport of cationic amphiphilics. Another prominent feature of this protein is its high content of aromatic amino acid residues (>23%) in its transmembrane segments. These aromatic amino acid residues have been suggested to be involved in the drug transport by the P-glycoprotein. Mutations in this gene cause Chondrodysplasia punctata 2 (CDPX2; also known as Conradi-Hunermann syndrome). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.21251360
2L-phenylalanine catabolic process (GO:0006559)7.21251360
3L-phenylalanine metabolic process (GO:0006558)6.93492613
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.93492613
5aromatic amino acid family catabolic process (GO:0009074)6.50712236
6indole-containing compound catabolic process (GO:0042436)5.85389986
7indolalkylamine catabolic process (GO:0046218)5.85389986
8tryptophan catabolic process (GO:0006569)5.85389986
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.69431859
10kynurenine metabolic process (GO:0070189)5.57316278
11glyoxylate metabolic process (GO:0046487)5.55198827
12tryptophan metabolic process (GO:0006568)5.51490039
13bile acid biosynthetic process (GO:0006699)5.51374672
14sulfur amino acid catabolic process (GO:0000098)5.39311593
15proteasome assembly (GO:0043248)5.16046233
16cysteine metabolic process (GO:0006534)5.14009911
17alpha-linolenic acid metabolic process (GO:0036109)5.10035627
18urea metabolic process (GO:0019627)5.09003823
19urea cycle (GO:0000050)5.09003823
20high-density lipoprotein particle remodeling (GO:0034375)5.06558498
21complement activation, alternative pathway (GO:0006957)5.06181110
22negative regulation of fibrinolysis (GO:0051918)5.02393573
23peptidyl-glutamic acid carboxylation (GO:0017187)4.98028608
24protein carboxylation (GO:0018214)4.98028608
25regulation of protein activation cascade (GO:2000257)4.95706438
26serine family amino acid catabolic process (GO:0009071)4.85752810
27aromatic amino acid family metabolic process (GO:0009072)4.82105753
28regulation of fibrinolysis (GO:0051917)4.81827692
29bile acid metabolic process (GO:0008206)4.72975252
30nitrogen cycle metabolic process (GO:0071941)4.69905970
31homocysteine metabolic process (GO:0050667)4.68096576
32regulation of complement activation (GO:0030449)4.65961305
33fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.61708464
34tyrosine metabolic process (GO:0006570)4.55841808
35mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.55329082
36regulation of cholesterol esterification (GO:0010872)4.55259102
37regulation of triglyceride catabolic process (GO:0010896)4.52506366
38glycine metabolic process (GO:0006544)4.37921897
39amino-acid betaine metabolic process (GO:0006577)4.35294109
40protein-lipid complex remodeling (GO:0034368)4.34795024
41macromolecular complex remodeling (GO:0034367)4.34795024
42plasma lipoprotein particle remodeling (GO:0034369)4.34795024
43alpha-amino acid catabolic process (GO:1901606)4.34654218
44bile acid and bile salt transport (GO:0015721)4.32885860
45reverse cholesterol transport (GO:0043691)4.31900143
46negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.31505459
47coenzyme catabolic process (GO:0009109)4.25506556
48lysine catabolic process (GO:0006554)4.25306929
49lysine metabolic process (GO:0006553)4.25306929
50aldehyde catabolic process (GO:0046185)4.24982512
51triglyceride homeostasis (GO:0070328)4.23699503
52acylglycerol homeostasis (GO:0055090)4.23699503
53serine family amino acid biosynthetic process (GO:0009070)4.21112936
54indolalkylamine metabolic process (GO:0006586)4.19504322
55phospholipid efflux (GO:0033700)4.18827054
56serine family amino acid metabolic process (GO:0009069)4.17016463
57negative regulation of sterol transport (GO:0032372)4.16483519
58negative regulation of cholesterol transport (GO:0032375)4.16483519
59cellular biogenic amine catabolic process (GO:0042402)4.16065347
60amine catabolic process (GO:0009310)4.16065347
61cellular glucuronidation (GO:0052695)4.12315470
62imidazole-containing compound metabolic process (GO:0052803)4.08864222
63regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.08171309
64plasma lipoprotein particle clearance (GO:0034381)4.07600761
65regulation of cellular amino acid metabolic process (GO:0006521)4.06463871
66cellular amino acid catabolic process (GO:0009063)4.03303292
67positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.02287936
68cellular ketone body metabolic process (GO:0046950)4.01077732
69telomere maintenance via semi-conservative replication (GO:0032201)3.97782098
70ethanol oxidation (GO:0006069)3.96532594
71ATP synthesis coupled proton transport (GO:0015986)3.93780412
72energy coupled proton transport, down electrochemical gradient (GO:0015985)3.93780412
73negative regulation of ligase activity (GO:0051352)3.93219629
74negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.93219629
75DNA strand elongation involved in DNA replication (GO:0006271)3.92876096
76anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.92170323
77cofactor catabolic process (GO:0051187)3.90815154
78benzene-containing compound metabolic process (GO:0042537)3.87238843
79cholesterol efflux (GO:0033344)3.87046947
80cellular modified amino acid catabolic process (GO:0042219)3.80212219
81DNA strand elongation (GO:0022616)3.74945162
82drug catabolic process (GO:0042737)3.74871329
83uronic acid metabolic process (GO:0006063)3.73910894
84glucuronate metabolic process (GO:0019585)3.73910894
85establishment of protein localization to mitochondrial membrane (GO:0090151)3.73510534
86fibrinolysis (GO:0042730)3.71868106
87DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.70952631
88glutamate metabolic process (GO:0006536)3.69737604
89low-density lipoprotein particle remodeling (GO:0034374)3.69580532
90arginine metabolic process (GO:0006525)3.69482444
91positive regulation of triglyceride lipase activity (GO:0061365)3.67056345
92positive regulation of lipoprotein lipase activity (GO:0051006)3.67056345
93chaperone-mediated protein transport (GO:0072321)3.66814510
94NAD biosynthetic process (GO:0009435)3.66476236
95short-chain fatty acid metabolic process (GO:0046459)3.65636499
96signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.65448247
97signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.65448247
98signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.65448247
99intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.64761717
100signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.64761717
101acetyl-CoA metabolic process (GO:0006084)3.64009325
102mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.63138083
103plasma lipoprotein particle assembly (GO:0034377)3.62939079
104blood coagulation, intrinsic pathway (GO:0007597)3.61231003
105nicotinamide nucleotide biosynthetic process (GO:0019359)3.59904485
106pyridine nucleotide biosynthetic process (GO:0019363)3.59904485
107carboxylic acid catabolic process (GO:0046395)3.59788255
108organic acid catabolic process (GO:0016054)3.59788255
109positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.58664710
110heme transport (GO:0015886)3.58419258
111chromatin remodeling at centromere (GO:0031055)3.57305949
112signal transduction involved in DNA damage checkpoint (GO:0072422)3.55379551
113signal transduction involved in DNA integrity checkpoint (GO:0072401)3.55379551
114complement activation (GO:0006956)3.55323600
115DNA replication checkpoint (GO:0000076)3.55297206
116complement activation, classical pathway (GO:0006958)3.55268165
117cholesterol homeostasis (GO:0042632)3.54985755
118respiratory electron transport chain (GO:0022904)3.54166252
119very-low-density lipoprotein particle assembly (GO:0034379)3.52008788
120signal transduction involved in cell cycle checkpoint (GO:0072395)3.50768976
121opsonization (GO:0008228)3.50356002
122CENP-A containing nucleosome assembly (GO:0034080)3.49858154
123protein activation cascade (GO:0072376)3.48933834
124ketone body metabolic process (GO:1902224)3.48622767
125sterol homeostasis (GO:0055092)3.47895963
126electron transport chain (GO:0022900)3.45322771
127positive regulation of ligase activity (GO:0051351)3.42854957
128regulation of mitochondrial translation (GO:0070129)3.41273646
129cullin deneddylation (GO:0010388)3.40248201
130L-serine metabolic process (GO:0006563)3.39751871
131urate metabolic process (GO:0046415)3.37700014
132cytolysis (GO:0019835)3.36173759
133rRNA modification (GO:0000154)3.35338344
134regulation of bile acid biosynthetic process (GO:0070857)3.33442691
135drug metabolic process (GO:0017144)3.32429996
136regulation of cholesterol metabolic process (GO:0090181)3.32034590
137protein complex biogenesis (GO:0070271)3.31277033
138telomere maintenance via recombination (GO:0000722)3.28343899
139respiratory chain complex IV assembly (GO:0008535)3.27642864
140mitochondrial respiratory chain complex assembly (GO:0033108)3.27550873
141regulation of ubiquitin-protein transferase activity (GO:0051438)3.24464997
142purine nucleobase biosynthetic process (GO:0009113)3.23926954
143protein deneddylation (GO:0000338)3.23692725
144transcription elongation from RNA polymerase III promoter (GO:0006385)3.20820131
145termination of RNA polymerase III transcription (GO:0006386)3.20820131
146pseudouridine synthesis (GO:0001522)3.18512592
147nucleobase biosynthetic process (GO:0046112)3.15461611
148mitotic recombination (GO:0006312)3.15231791
149establishment of integrated proviral latency (GO:0075713)3.14630940
150DNA double-strand break processing (GO:0000729)3.13839597
151regulation of cellular amine metabolic process (GO:0033238)3.12997094
152regulation of ligase activity (GO:0051340)3.12617436
153nucleotide-excision repair, DNA gap filling (GO:0006297)3.05926734
154mitotic sister chromatid segregation (GO:0000070)3.05093040
155protein targeting to mitochondrion (GO:0006626)3.03782078
156protein maturation by protein folding (GO:0022417)3.02910821
157kinetochore organization (GO:0051383)3.02744343
158kinetochore assembly (GO:0051382)3.02396470
159replication fork processing (GO:0031297)3.01725719
160cytochrome complex assembly (GO:0017004)2.99303186
161DNA catabolic process, exonucleolytic (GO:0000738)2.99192989
162* cholesterol biosynthetic process (GO:0006695)2.98621430
163mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.96350558
164mitochondrial respiratory chain complex I assembly (GO:0032981)2.96350558
165NADH dehydrogenase complex assembly (GO:0010257)2.96350558
166mitotic metaphase plate congression (GO:0007080)2.95423132
167histone exchange (GO:0043486)2.95368748
168exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.93276578
169nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.93096981
170inner mitochondrial membrane organization (GO:0007007)2.90716124
171protein neddylation (GO:0045116)2.88551632
172oxidative phosphorylation (GO:0006119)2.87755758
173protein localization to kinetochore (GO:0034501)2.85439943
174resolution of meiotic recombination intermediates (GO:0000712)2.83413513
175telomere maintenance via telomere lengthening (GO:0010833)2.83228322
176tricarboxylic acid cycle (GO:0006099)2.82882052
177DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.82059522
178DNA damage response, detection of DNA damage (GO:0042769)2.81280031
179G1/S transition of mitotic cell cycle (GO:0000082)2.81011994
180cell cycle G1/S phase transition (GO:0044843)2.81011994
181establishment of protein localization to mitochondrion (GO:0072655)2.78913211
182* sterol biosynthetic process (GO:0016126)2.78827870
183positive regulation of cell cycle arrest (GO:0071158)2.78421035
184protein-cofactor linkage (GO:0018065)2.77248145
185protein localization to mitochondrion (GO:0070585)2.77114601
186transcription-coupled nucleotide-excision repair (GO:0006283)2.77009227
187ribosome assembly (GO:0042255)2.76448586
188spliceosomal snRNP assembly (GO:0000387)2.73710337
189DNA replication initiation (GO:0006270)2.70851213
190metaphase plate congression (GO:0051310)2.70747192
191rRNA methylation (GO:0031167)2.70199779

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.39224537
2E2F7_22180533_ChIP-Seq_HELA_Human6.67407231
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.47433781
4PPARA_22158963_ChIP-Seq_LIVER_Mouse6.45831219
5LXR_22158963_ChIP-Seq_LIVER_Mouse5.55791796
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.11555194
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.82140207
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.59989644
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.06478311
10E2F4_17652178_ChIP-ChIP_JURKAT_Human3.56732224
11* MYC_18555785_ChIP-Seq_MESCs_Mouse3.54670474
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.13001801
13ETS1_20019798_ChIP-Seq_JURKAT_Human3.05911779
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.99093309
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.92604945
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.65956418
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.65640208
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.64358887
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.63053335
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.34082203
21ELK1_19687146_ChIP-ChIP_HELA_Human2.31167656
22HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.24172612
23THAP11_20581084_ChIP-Seq_MESCs_Mouse2.20803703
24MYC_19079543_ChIP-ChIP_MESCs_Mouse2.19514029
25VDR_23849224_ChIP-Seq_CD4+_Human2.17843354
26NELFA_20434984_ChIP-Seq_ESCs_Mouse2.13814329
27FOXP3_21729870_ChIP-Seq_TREG_Human2.11082958
28ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.6223288
29GABP_19822575_ChIP-Seq_HepG2_Human1.99590973
30XRN2_22483619_ChIP-Seq_HELA_Human1.97946746
31TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97688837
32IRF8_22096565_ChIP-ChIP_GC-B_Human1.91359380
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83275248
34TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.82533120
35TTF2_22483619_ChIP-Seq_HELA_Human1.80676656
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.78791709
37STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.78111774
38ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.73689135
39* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.72632968
40MYCN_18555785_ChIP-Seq_MESCs_Mouse1.68246597
41E2F1_21310950_ChIP-Seq_MCF-7_Human1.67177632
42MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.64991321
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.62269108
44POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.56779434
45NANOG_18555785_ChIP-Seq_MESCs_Mouse1.54690972
46GATA1_22025678_ChIP-Seq_K562_Human1.52944095
47PADI4_21655091_ChIP-ChIP_MCF-7_Human1.51189399
48MYC_18940864_ChIP-ChIP_HL60_Human1.47668503
49E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.46715511
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45594801
51MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.41194638
52POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.40004672
53IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.37101255
54KDM5A_27292631_Chip-Seq_BREAST_Human1.32477462
55HTT_18923047_ChIP-ChIP_STHdh_Human1.32326431
56ZFX_18555785_ChIP-Seq_MESCs_Mouse1.27279030
57CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25437730
58CLOCK_20551151_ChIP-Seq_293T_Human1.25039908
59TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.23524224
60STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.21924558
61NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.21095112
62RXRA_24833708_ChIP-Seq_LIVER_Mouse1.20565408
63HNF4A_19822575_ChIP-Seq_HepG2_Human1.19165477
64ELF1_17652178_ChIP-ChIP_JURKAT_Human1.17018970
65E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14742321
66KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.13427158
67ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11063229
68* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.11041192
69PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.10571725
70SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.09623437
71ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07388169
72CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.07085294
73NANOG_16153702_ChIP-ChIP_HESCs_Human1.05486677
74FOXA2_19822575_ChIP-Seq_HepG2_Human1.04689763
75EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.03932072
76SOX2_27498859_Chip-Seq_STOMACH_Mouse1.03199091
77ERG_20887958_ChIP-Seq_HPC-7_Mouse1.01941316
78KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.01167481
79RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.00667280
80NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.98871120
81SOX2_18555785_ChIP-Seq_MESCs_Mouse0.98807433
82ZNF274_21170338_ChIP-Seq_K562_Hela0.97827138
83PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.96467074
84SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.96221459
85STAT3_1855785_ChIP-Seq_MESCs_Mouse0.95964821
86VDR_22108803_ChIP-Seq_LS180_Human0.94822801
87KAP1_22055183_ChIP-Seq_ESCs_Mouse0.94241896
88RARG_19884340_ChIP-ChIP_MEFs_Mouse0.93413210
89* GATA4_25053715_ChIP-Seq_YYC3_Human0.93001978
90SRF_21415370_ChIP-Seq_HL-1_Mouse0.92713991
91THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.91881871
92DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.91670743
93ELK1_22589737_ChIP-Seq_MCF10A_Human0.90613427
94BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.89078730
95HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.88680632
96IRF8_21731497_ChIP-ChIP_J774_Mouse0.88428357
97SOX17_20123909_ChIP-Seq_XEN_Mouse0.87852854
98JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.87586356
99BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.87016673
100RARA_24833708_ChIP-Seq_LIVER_Mouse0.86795844
101SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.85188518
102NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.84386123
103TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.83643990
104KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.81761661
105TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.81737426
106NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.81730114
107IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.80987623
108CREB1_15753290_ChIP-ChIP_HEK293T_Human0.80227823
109SOX2_16153702_ChIP-ChIP_HESCs_Human0.79801383
110POU5F1_16153702_ChIP-ChIP_HESCs_Human0.78875549
111RARB_24833708_ChIP-Seq_LIVER_Mouse0.77777205
112SALL1_21062744_ChIP-ChIP_HESCs_Human0.77231630
113PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.77229504
114CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.73605161
115Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.73575258
116ZNF263_19887448_ChIP-Seq_K562_Human0.73001900
117EOMES_21245162_ChIP-Seq_HESCs_Human0.72878310
118SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.71287084
119SALL4_18804426_ChIP-ChIP_XEN_Mouse0.70810596
120* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.70080338
121NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.69876146
122ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.69727319
123PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.69635837
124FOXP1_21924763_ChIP-Seq_HESCs_Human0.69559725
125CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.69398742
126CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.68955750
127KLF4_18555785_ChIP-Seq_MESCs_Mouse0.68071131
128ESR1_15608294_ChIP-ChIP_MCF-7_Human0.67762176
129RAD21_21589869_ChIP-Seq_MESCs_Mouse0.66519728
130RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.64021077
131POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.62814065
132CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.62605826
133CEBPB_22108803_ChIP-Seq_LS180_Human0.62317090
134CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.61994090
135AUTS2_25519132_ChIP-Seq_293T-REX_Human0.61290449
136IRF1_19129219_ChIP-ChIP_H3396_Human0.61046662
137GABP_17652178_ChIP-ChIP_JURKAT_Human0.60200073
138GATA1_22383799_ChIP-Seq_G1ME_Mouse0.58692302
139NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.58631558
140MYC_18358816_ChIP-ChIP_MESCs_Mouse0.58369184
141BRD4_27068464_Chip-Seq_AML-cells_Mouse0.58168817
142AR_20517297_ChIP-Seq_VCAP_Human0.57925314
143* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.57612012
144EGR1_19032775_ChIP-ChIP_M12_Human0.57249836
145GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.57132779
146IRF8_27001747_Chip-Seq_BMDM_Mouse0.56748888
147FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.56678410
148SRY_22984422_ChIP-ChIP_TESTIS_Rat0.55958250
149TAF2_19829295_ChIP-Seq_ESCs_Human0.55492846
150OCT4_18692474_ChIP-Seq_MEFs_Mouse0.55125196
151* BCOR_27268052_Chip-Seq_Bcells_Human0.55000183
152GATA2_22383799_ChIP-Seq_G1ME_Mouse0.54527159
153CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.54309968
154AR_21909140_ChIP-Seq_LNCAP_Human0.53760776
155CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.53114320
156SOX2_18692474_ChIP-Seq_MEFs_Mouse0.53022210
157PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.52489728
158FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.51206096
159SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.51078596
160P53_21459846_ChIP-Seq_SAOS-2_Human0.50557146
161PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.50044135
162CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.49988161
163LXR_22292898_ChIP-Seq_THP-1_Human0.49959467
164MYC_19915707_ChIP-ChIP_AK7_Human0.49698730
165SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.49092311
166DCP1A_22483619_ChIP-Seq_HELA_Human0.48853501
167PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.48779628
168EST1_17652178_ChIP-ChIP_JURKAT_Human0.48746354

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.63316251
2MP0005360_urolithiasis7.02664460
3MP0005085_abnormal_gallbladder_physiolo5.92080979
4MP0005365_abnormal_bile_salt5.66204206
5MP0008875_abnormal_xenobiotic_pharmacok4.89641686
6MP0003806_abnormal_nucleotide_metabolis4.61526894
7MP0003693_abnormal_embryo_hatching3.94563653
8MP0010094_abnormal_chromosome_stability3.93503939
9MP0003252_abnormal_bile_duct3.51687625
10MP0008058_abnormal_DNA_repair3.50238815
11MP0009840_abnormal_foam_cell3.36744624
12MP0010329_abnormal_lipoprotein_level3.22378267
13MP0004957_abnormal_blastocyst_morpholog3.19072209
14MP0003195_calcinosis3.06045033
15MP0003111_abnormal_nucleus_morphology2.91320411
16MP0005083_abnormal_biliary_tract2.90044054
17MP0005332_abnormal_amino_acid2.75686202
18MP0001666_abnormal_nutrient_absorption2.58108989
19MP0008932_abnormal_embryonic_tissue2.53084867
20MP0003786_premature_aging2.48082824
21MP0003077_abnormal_cell_cycle2.40357701
22MP0008007_abnormal_cellular_replicative2.36593595
23MP0003123_paternal_imprinting2.33653480
24MP0003191_abnormal_cellular_cholesterol2.31151332
25MP0000372_irregular_coat_pigmentation2.29504991
26MP0004019_abnormal_vitamin_homeostasis2.26383479
27MP0000609_abnormal_liver_physiology2.09821295
28MP0002118_abnormal_lipid_homeostasis1.98305916
29MP0002138_abnormal_hepatobiliary_system1.96540349
30MP0008057_abnormal_DNA_replication1.95302674
31MP0006292_abnormal_olfactory_placode1.92664834
32MP0002938_white_spotting1.90494482
33MP0001764_abnormal_homeostasis1.89232739
34MP0005319_abnormal_enzyme/_coenzyme1.87136919
35MP0003186_abnormal_redox_activity1.82924936
36MP0008877_abnormal_DNA_methylation1.68544694
37MP0001529_abnormal_vocalization1.66914732
38MP0005451_abnormal_body_composition1.65178630
39MP0003121_genomic_imprinting1.64395969
40MP0003868_abnormal_feces_composition1.63199012
41MP0005584_abnormal_enzyme/coenzyme_acti1.60316600
42MP0003656_abnormal_erythrocyte_physiolo1.58999101
43MP0002102_abnormal_ear_morphology1.48201872
44MP0009643_abnormal_urine_homeostasis1.47632745
45MP0002163_abnormal_gland_morphology1.47593710
46MP0003941_abnormal_skin_development1.47504813
47MP0003011_delayed_dark_adaptation1.39586086
48MP0009697_abnormal_copulation1.35830983
49MP0010030_abnormal_orbit_morphology1.33265776
50MP0001293_anophthalmia1.28485579
51MP0008995_early_reproductive_senescence1.24761561
52MP0000598_abnormal_liver_morphology1.20587235
53MP0008469_abnormal_protein_level1.16699009
54MP0005636_abnormal_mineral_homeostasis1.16205641
55MP0009764_decreased_sensitivity_to1.16025893
56MP0002210_abnormal_sex_determination1.15119338
57MP0000358_abnormal_cell_content/1.14797209
58MP0002234_abnormal_pharynx_morphology1.13280215
59MP0001929_abnormal_gametogenesis1.10750738
60MP0009763_increased_sensitivity_to1.09087162
61MP0003122_maternal_imprinting1.08846478
62MP0003890_abnormal_embryonic-extraembry1.07884607
63MP0001730_embryonic_growth_arrest1.06822580
64MP0001697_abnormal_embryo_size1.05906672
65MP0006036_abnormal_mitochondrial_physio1.05547285
66MP0000604_amyloidosis1.05497736
67MP0000647_abnormal_sebaceous_gland1.05148393
68MP0005408_hypopigmentation1.01541068
69MP0008872_abnormal_physiological_respon1.01430729
70MP0006072_abnormal_retinal_apoptosis1.00463602
71MP0005647_abnormal_sex_gland0.99079679
72MP0005084_abnormal_gallbladder_morpholo0.97679202
73MP0003436_decreased_susceptibility_to0.96917435
74MP0000653_abnormal_sex_gland0.95595586
75MP0005058_abnormal_lysosome_morphology0.94482825
76MP0008789_abnormal_olfactory_epithelium0.94374761
77MP0005379_endocrine/exocrine_gland_phen0.94172731
78MP0002736_abnormal_nociception_after0.93571258
79MP0002160_abnormal_reproductive_system0.93331205
80MP0002090_abnormal_vision0.93188774
81MP0003724_increased_susceptibility_to0.92806840
82MP0003119_abnormal_digestive_system0.91900798
83MP0001145_abnormal_male_reproductive0.91817580
84MP0003567_abnormal_fetal_cardiomyocyte0.90250172
85MP0009642_abnormal_blood_homeostasis0.89360613
86MP0009765_abnormal_xenobiotic_induced0.88480577
87MP0003937_abnormal_limbs/digits/tail_de0.87919575
88MP0005376_homeostasis/metabolism_phenot0.87210932
89MP0005380_embryogenesis_phenotype0.85687773
90MP0001672_abnormal_embryogenesis/_devel0.85687773
91MP0005389_reproductive_system_phenotype0.85550527
92MP0003718_maternal_effect0.84855384
93MP0003315_abnormal_perineum_morphology0.84147909
94MP0000350_abnormal_cell_proliferation0.83980820
95MP0006082_CNS_inflammation0.82153453
96MP0002876_abnormal_thyroid_physiology0.81284401
97MP0001756_abnormal_urination0.80862067
98MP0001919_abnormal_reproductive_system0.80477932
99MP0002080_prenatal_lethality0.80125539
100MP0003705_abnormal_hypodermis_morpholog0.79603265
101MP0001119_abnormal_female_reproductive0.79522152
102MP0004782_abnormal_surfactant_physiolog0.76974368
103MP0000313_abnormal_cell_death0.76763438
104MP0001661_extended_life_span0.76575373
105MP0005464_abnormal_platelet_physiology0.76540799
106MP0003950_abnormal_plasma_membrane0.75897504
107MP0009672_abnormal_birth_weight0.74004375
108MP0005499_abnormal_olfactory_system0.73488019
109MP0005394_taste/olfaction_phenotype0.73488019
110MP0009785_altered_susceptibility_to0.73442473
111MP0002282_abnormal_trachea_morphology0.73095083
112MP0005220_abnormal_exocrine_pancreas0.72826060
113MP0002085_abnormal_embryonic_tissue0.72692912
114MP0001324_abnormal_eye_pigmentation0.72261169
115MP0000516_abnormal_urinary_system0.71830296
116MP0005367_renal/urinary_system_phenotyp0.71830296
117MP0001286_abnormal_eye_development0.71648024
118MP0005266_abnormal_metabolism0.70172209
119MP0002233_abnormal_nose_morphology0.69512568
120MP0006035_abnormal_mitochondrial_morpho0.68414686
121MP0002084_abnormal_developmental_patter0.66662828
122MP0002254_reproductive_system_inflammat0.65830711
123MP0005551_abnormal_eye_electrophysiolog0.65575924
124MP0002078_abnormal_glucose_homeostasis0.64653537
125MP0003984_embryonic_growth_retardation0.64529078
126MP0002136_abnormal_kidney_physiology0.64484845
127MP0002088_abnormal_embryonic_growth/wei0.64377603
128MP0005395_other_phenotype0.63136713
129MP0001845_abnormal_inflammatory_respons0.61620616
130MP0005670_abnormal_white_adipose0.60957532
131MP0002132_abnormal_respiratory_system0.60159477
132MP0005334_abnormal_fat_pad0.59577039
133MP0004381_abnormal_hair_follicle0.59410775
134MP0005025_abnormal_response_to0.58878147
135MP0003690_abnormal_glial_cell0.58269246
136MP0008873_increased_physiological_sensi0.57735748
137MP0010368_abnormal_lymphatic_system0.56575754
138MP0002971_abnormal_brown_adipose0.54880609
139MP0002419_abnormal_innate_immunity0.53919552
140MP0002796_impaired_skin_barrier0.52256235
141MP0001835_abnormal_antigen_presentation0.51957679
142MP0009053_abnormal_anal_canal0.51874134
143MP0003329_amyloid_beta_deposits0.51832933
144MP0005535_abnormal_body_temperature0.50573609
145MP0003638_abnormal_response/metabolism_0.49915586
146MP0004147_increased_porphyrin_level0.46876208
147MP0003075_altered_response_to0.45543328
148MP0001243_abnormal_dermal_layer0.45228532
149MP0004947_skin_inflammation0.45175872
150MP0000639_abnormal_adrenal_gland0.44370327
151MP0001853_heart_inflammation0.44318099
152MP0005075_abnormal_melanosome_morpholog0.43846657
153MP0005448_abnormal_energy_balance0.43525043
154MP0005166_decreased_susceptibility_to0.42548263
155MP0001881_abnormal_mammary_gland0.41461129
156MP0001533_abnormal_skeleton_physiology0.41449258
157MP0010155_abnormal_intestine_physiology0.41081070
158MP0000685_abnormal_immune_system0.39521902
159MP0001542_abnormal_bone_strength0.38974702
160MP0004130_abnormal_muscle_cell0.36064782
161MP0000249_abnormal_blood_vessel0.35857663
162MP0002928_abnormal_bile_duct0.34901038
163MP0001790_abnormal_immune_system0.34215324
164MP0005387_immune_system_phenotype0.34215324
165MP0004043_abnormal_pH_regulation0.34186226
166MP0004264_abnormal_extraembryonic_tissu0.33118147
167MP0002060_abnormal_skin_morphology0.33106166
168MP0001800_abnormal_humoral_immune0.32897809

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.03585547
2Intrahepatic cholestasis (HP:0001406)6.71551151
3Deep venous thrombosis (HP:0002625)6.38280418
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.23379189
5Prolonged partial thromboplastin time (HP:0003645)5.93275293
6Hypobetalipoproteinemia (HP:0003563)5.90467878
7Xanthomatosis (HP:0000991)5.78912576
8Hyperlipoproteinemia (HP:0010980)5.06937923
9Acute necrotizing encephalopathy (HP:0006965)4.88659174
10Complement deficiency (HP:0004431)4.86423786
11Acute encephalopathy (HP:0006846)4.70984680
12Abnormal mitochondria in muscle tissue (HP:0008316)4.64475665
13Joint hemorrhage (HP:0005261)4.45292338
14Hyperglycinemia (HP:0002154)4.38616414
15Hyperammonemia (HP:0001987)4.34324775
16Hypolipoproteinemia (HP:0010981)4.26694221
17Increased serum pyruvate (HP:0003542)4.15073325
18Abnormality of methionine metabolism (HP:0010901)4.13029402
19Abnormality of the common coagulation pathway (HP:0010990)4.07657647
20Abnormality of glycolysis (HP:0004366)4.07123508
21Mitochondrial inheritance (HP:0001427)4.06243147
22Abnormality of sulfur amino acid metabolism (HP:0004339)4.05723216
23Increased CSF lactate (HP:0002490)4.00993145
24Progressive macrocephaly (HP:0004481)3.99810451
25Abnormality of aspartate family amino acid metabolism (HP:0010899)3.97820658
26Hyperglycinuria (HP:0003108)3.96960195
27Fat malabsorption (HP:0002630)3.96290548
28Abnormality of serine family amino acid metabolism (HP:0010894)3.94230229
29Abnormality of glycine metabolism (HP:0010895)3.94230229
30Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.93422535
31Abnormality of glutamine family amino acid metabolism (HP:0010902)3.90970172
32Ketosis (HP:0001946)3.85530712
33Hepatocellular necrosis (HP:0001404)3.84827281
34Epidermoid cyst (HP:0200040)3.83598799
35Hypoglycemic coma (HP:0001325)3.78955188
36Abnormality of pyrimidine metabolism (HP:0004353)3.75492386
37Abnormality of complement system (HP:0005339)3.69310007
38Abnormality of the intrinsic pathway (HP:0010989)3.55212597
39Hypoalphalipoproteinemia (HP:0003233)3.54989539
40Abnormality of fatty-acid metabolism (HP:0004359)3.46330982
41Conjugated hyperbilirubinemia (HP:0002908)3.40799682
42Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.36490881
43Chromosomal breakage induced by crosslinking agents (HP:0003221)3.23062594
44Hypercholesterolemia (HP:0003124)3.20278023
45Hyperbilirubinemia (HP:0002904)3.19951837
46Steatorrhea (HP:0002570)3.15087477
47Increased hepatocellular lipid droplets (HP:0006565)3.14422515
48Abnormality of serum amino acid levels (HP:0003112)3.09107799
49Delayed CNS myelination (HP:0002188)3.04957352
50Increased serum lactate (HP:0002151)3.04801398
51Systemic lupus erythematosus (HP:0002725)3.04486054
52Abnormality of nucleobase metabolism (HP:0010932)3.03307185
53Chromsome breakage (HP:0040012)2.96715329
54Abnormality of dicarboxylic acid metabolism (HP:0010995)2.95692797
55Dicarboxylic aciduria (HP:0003215)2.95692797
56Lipid accumulation in hepatocytes (HP:0006561)2.94894098
57Renal Fanconi syndrome (HP:0001994)2.92099371
58Lethargy (HP:0001254)2.84443092
59Lactic acidosis (HP:0003128)2.83193466
60Reticulocytopenia (HP:0001896)2.79305828
61Hepatocellular carcinoma (HP:0001402)2.76570678
62Myocardial infarction (HP:0001658)2.75342244
63Metabolic acidosis (HP:0001942)2.71454354
64Abnormality of the preputium (HP:0100587)2.71442456
65Meckel diverticulum (HP:0002245)2.70702074
66Ketoacidosis (HP:0001993)2.70073040
67Abnormality of purine metabolism (HP:0004352)2.67214585
68Cerebral edema (HP:0002181)2.62950884
69Recurrent gram-negative bacterial infections (HP:0005420)2.61847293
70Gout (HP:0001997)2.60282978
71Type I transferrin isoform profile (HP:0003642)2.58705058
72Abnormality of the ileum (HP:0001549)2.58335989
73Spontaneous abortion (HP:0005268)2.54224995
74Generalized aminoaciduria (HP:0002909)2.53793196
75Aplasia/Hypoplasia of the uvula (HP:0010293)2.53145893
76Abnormality of alanine metabolism (HP:0010916)2.53124858
77Hyperalaninemia (HP:0003348)2.53124858
78Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.53124858
79Glomerulonephritis (HP:0000099)2.48590882
80Vascular calcification (HP:0004934)2.47496068
81Respiratory failure (HP:0002878)2.46411141
82Decreased activity of mitochondrial respiratory chain (HP:0008972)2.44782652
83Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.44782652
84Increased intramyocellular lipid droplets (HP:0012240)2.44593718
85Irritability (HP:0000737)2.40775576
86Hypochromic microcytic anemia (HP:0004840)2.38338676
87Exercise intolerance (HP:0003546)2.38080745
88Horseshoe kidney (HP:0000085)2.36384512
89Acanthocytosis (HP:0001927)2.36236727
90Skin nodule (HP:0200036)2.35587714
91Abnormal lung lobation (HP:0002101)2.35362219
92Abnormality of the labia minora (HP:0012880)2.34202485
93Abnormality of chromosome stability (HP:0003220)2.29608649
94Leukodystrophy (HP:0002415)2.28237927
95Abnormal gallbladder morphology (HP:0012437)2.27915714
96Respiratory difficulties (HP:0002880)2.27379142
97Hypoglycemic seizures (HP:0002173)2.26708195
98Methylmalonic aciduria (HP:0012120)2.26362739
99Reduced antithrombin III activity (HP:0001976)2.25678656
100Spastic diplegia (HP:0001264)2.25155247
101Abnormal cartilage morphology (HP:0002763)2.24364237
102Optic disc pallor (HP:0000543)2.23166789
103Amyloidosis (HP:0011034)2.22042651
104Vomiting (HP:0002013)2.21848023
105CNS demyelination (HP:0007305)2.21056398
106Hypoplastic pelvis (HP:0008839)2.20558401
107Opisthotonus (HP:0002179)2.19945656
108Pancreatitis (HP:0001733)2.19079716
109Gingival bleeding (HP:0000225)2.18329289
110Methylmalonic acidemia (HP:0002912)2.17996725
111Aplasia/Hypoplasia of the sacrum (HP:0008517)2.17960076
112Cholelithiasis (HP:0001081)2.16378961
113Cardiovascular calcification (HP:0011915)2.16068350
114Small intestinal stenosis (HP:0012848)2.11575835
115Duodenal stenosis (HP:0100867)2.11575835
116Abnormality of iron homeostasis (HP:0011031)2.10665601
117Birth length less than 3rd percentile (HP:0003561)2.09968812
118Abnormal protein glycosylation (HP:0012346)2.09766726
119Abnormal glycosylation (HP:0012345)2.09766726
120Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.09766726
121Abnormal protein N-linked glycosylation (HP:0012347)2.09766726
122Brushfield spots (HP:0001088)2.09619965
123Malnutrition (HP:0004395)2.07839777
124Renal cortical cysts (HP:0000803)2.06422604
125Abnormality of transition element cation homeostasis (HP:0011030)2.06092504
126Abnormal gallbladder physiology (HP:0012438)2.06089529
127Cholecystitis (HP:0001082)2.06089529
128Pancytopenia (HP:0001876)2.05420003
129Glycosuria (HP:0003076)2.04526361
130Abnormality of urine glucose concentration (HP:0011016)2.04526361
131Absent thumb (HP:0009777)2.03356684
132* X-linked dominant inheritance (HP:0001423)2.01967598
133Neonatal onset (HP:0003623)2.01857535
134Increased muscle lipid content (HP:0009058)2.01190348
135Colon cancer (HP:0003003)2.00915418
136Bifid tongue (HP:0010297)2.00077626
137Mitral stenosis (HP:0001718)1.99939220
138Nausea (HP:0002018)1.98986978
139Rickets (HP:0002748)1.96870329
140Late onset (HP:0003584)1.96813470
141Proximal tubulopathy (HP:0000114)1.95061476
142Esophageal varix (HP:0002040)1.94810744
143Thrombophlebitis (HP:0004418)1.93336291
144Abnormality of the duodenum (HP:0002246)1.92954507
145Abnormal enzyme/coenzyme activity (HP:0012379)1.92571863
146Menorrhagia (HP:0000132)1.91474387
147Alkalosis (HP:0001948)1.91451943
148Pancreatic islet-cell hyperplasia (HP:0004510)1.90897374
149Hyperphosphaturia (HP:0003109)1.89824708
150Abnormality of the gallbladder (HP:0005264)1.89674060
151Poikilocytosis (HP:0004447)1.89071968
152Cerebral hypomyelination (HP:0006808)1.87394464
153Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.85309112
154Sensorimotor neuropathy (HP:0007141)1.85107197
155Elevated hepatic transaminases (HP:0002910)1.84765442
156Hypophosphatemic rickets (HP:0004912)1.82928060
157Hepatic necrosis (HP:0002605)1.82742756
158Increased serum ferritin (HP:0003281)1.82247465
1593-Methylglutaconic aciduria (HP:0003535)1.81661909
160Multiple enchondromatosis (HP:0005701)1.81354668
161Microvesicular hepatic steatosis (HP:0001414)1.79668275
162Vacuolated lymphocytes (HP:0001922)1.78981386
163Hemorrhage of the eye (HP:0011885)1.77874614
164Hydroxyprolinuria (HP:0003080)1.77096564
165Adrenal hypoplasia (HP:0000835)1.76489019
166Exertional dyspnea (HP:0002875)1.76231328
167Degeneration of anterior horn cells (HP:0002398)1.74212874
168Abnormality of the anterior horn cell (HP:0006802)1.74212874
169Ependymoma (HP:0002888)1.70957529
170Macrocytic anemia (HP:0001972)1.70627979
171Megaloblastic anemia (HP:0001889)1.69097615
172Abnormality of renal resorption (HP:0011038)1.69052287

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.47288667
2TAOK34.63551780
3ERN13.89164189
4FGFR43.74128781
5VRK23.64399732
6NEK13.43022075
7SIK12.78930074
8MST1R2.69520840
9CDC72.68935634
10PDK22.54722332
11SRPK12.44106227
12ZAK2.38112778
13TRIM282.29676998
14INSRR2.28192549
15TTK2.22489461
16BRSK22.21859802
17PLK32.17662918
18TSSK62.13159565
19FLT32.09792177
20PLK42.09297699
21TYK22.08260540
22ERBB42.00937891
23TBK11.94661226
24NME21.91854054
25KDR1.90518384
26VRK11.87356671
27BRSK11.85815227
28PIK3CG1.82250445
29MAP3K141.78864110
30ABL21.74366698
31WNK31.65491592
32NME11.65437653
33PBK1.63275756
34MAPK111.62820804
35MAP3K121.60216551
36PLK11.53866656
37STK161.44988899
38GRK61.44698425
39BMPR1B1.42584254
40IRAK31.42308322
41NEK91.34329737
42MKNK21.30111776
43EPHB11.27455070
44CHEK21.22698633
45MAP4K11.22444768
46IKBKE1.21836791
47MAP2K31.21816220
48MET1.20044809
49ATR1.19904573
50TAF11.15888136
51PKN21.15818128
52EIF2AK11.13404298
53PIM21.10555808
54EPHA21.10438536
55MKNK11.10282039
56DYRK21.08774976
57MAP3K111.07274038
58AURKB1.01706460
59MAP3K31.01653950
60BLK1.01586684
61PINK11.01453688
62EIF2AK31.00148483
63PLK20.99168120
64JAK20.94855441
65CSK0.94005814
66TESK20.92389439
67LIMK10.92182254
68MAP4K20.91648567
69JAK10.90624801
70ZAP700.88786249
71IKBKB0.88282546
72DAPK10.87384646
73STK38L0.87199832
74AURKA0.86385933
75TLK10.86092491
76PRKCI0.83728404
77MAPK40.83145967
78TNIK0.82228060
79TRIB30.80841665
80BCR0.79492480
81TESK10.78993730
82CSF1R0.78974217
83EIF2AK20.77979190
84MAP2K20.76633024
85TEC0.76596262
86IRAK40.75238573
87KIT0.73568754
88NEK20.73395401
89BTK0.73203213
90CDK80.73094286
91MAP2K40.73035828
92CSNK1G20.71685543
93CAMK2G0.70738700
94CSNK1A1L0.67823808
95ITK0.67204105
96PTK60.66791716
97MAPK150.64661262
98ATM0.63967356
99MAP3K80.63804679
100BUB10.63780415
101CCNB10.63600113
102CSNK2A20.63547383
103PRKCQ0.63262899
104CLK10.63167762
105STK40.62819648
106CHEK10.61672494
107TXK0.61034976
108CDK70.60664244
109MINK10.59740647
110ACVR1B0.59659939
111PRKAA20.59326605
112ARAF0.58019654
113MAP2K70.56724084
114AKT30.55695384
115PAK40.55605063
116MST40.54565106
117RPS6KA40.52562948
118PAK10.51958136
119FRK0.51353002
120NUAK10.51264208
121RPS6KA50.50717292
122CDK40.50298292
123GSK3A0.50255064
124CSNK1G10.49025428
125ILK0.49012209
126PRKACG0.48564717
127GRK10.47750806
128IRAK10.47175740
129LYN0.46139713
130MAP3K70.45997470
131PKN10.45148927
132DAPK20.44645210
133PDPK10.44308539
134CSNK1G30.43946069
135ERBB30.43060805
136MUSK0.42510183
137PRKCZ0.42161684
138JAK30.42122906
139PRKCG0.41195003
140MAPKAPK50.41048780
141DYRK1B0.40277463
142LRRK20.40218479
143PIM10.40036743
144STK390.39718881
145MAPK120.39499629
146MAP2K60.39182568
147CDK10.38326702
148TGFBR20.38294727
149ERBB20.37365320
150WNK40.36869372
151ADRBK20.36803557
152EPHA30.36271771
153OXSR10.35126815
154PRKCD0.35082588
155WEE10.34744726
156CDK60.34436153
157CSNK1E0.34229323
158CSNK1A10.33686390
159SYK0.33452354
160STK100.32625280
161NLK0.32074066
162FGFR10.31972076
163CASK0.31136634
164IGF1R0.30723704
165CSNK2A10.30245041
166FGFR20.28362088
167CDK20.27400442
168BRAF0.27243299
169PASK0.26432166
170MYLK0.25247132
171PRKDC0.23955813
172CDK180.23307182

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.15869877
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.28560573
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.93941073
4DNA replication_Homo sapiens_hsa030302.87953024
5Nitrogen metabolism_Homo sapiens_hsa009102.87895457
6Mismatch repair_Homo sapiens_hsa034302.71554447
7Arginine biosynthesis_Homo sapiens_hsa002202.70443162
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.63229970
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.57855465
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.56210497
11Tryptophan metabolism_Homo sapiens_hsa003802.56102321
12Complement and coagulation cascades_Homo sapiens_hsa046102.55124384
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.37419788
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.35983964
15Fatty acid degradation_Homo sapiens_hsa000712.35925252
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.16137087
17Peroxisome_Homo sapiens_hsa041462.11546855
18RNA polymerase_Homo sapiens_hsa030202.11308879
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.05989286
20Homologous recombination_Homo sapiens_hsa034402.04666556
21Histidine metabolism_Homo sapiens_hsa003402.04135366
22Butanoate metabolism_Homo sapiens_hsa006501.99984947
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.98969504
24Chemical carcinogenesis_Homo sapiens_hsa052041.96180040
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.94488688
26Ribosome_Homo sapiens_hsa030101.89320049
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.89023412
28Propanoate metabolism_Homo sapiens_hsa006401.86739299
29Staphylococcus aureus infection_Homo sapiens_hsa051501.81331490
30Caffeine metabolism_Homo sapiens_hsa002321.78165289
31Base excision repair_Homo sapiens_hsa034101.77881482
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.76625320
33Fatty acid metabolism_Homo sapiens_hsa012121.72357638
34beta-Alanine metabolism_Homo sapiens_hsa004101.70885534
35Retinol metabolism_Homo sapiens_hsa008301.70228607
36Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.69289514
37PPAR signaling pathway_Homo sapiens_hsa033201.69132575
38Sulfur metabolism_Homo sapiens_hsa009201.67043624
39Fanconi anemia pathway_Homo sapiens_hsa034601.66624666
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.62085818
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.59247323
42Non-homologous end-joining_Homo sapiens_hsa034501.58636083
43Huntingtons disease_Homo sapiens_hsa050161.56411226
44Fatty acid elongation_Homo sapiens_hsa000621.55960680
45Selenocompound metabolism_Homo sapiens_hsa004501.54514597
46Folate biosynthesis_Homo sapiens_hsa007901.53306197
47Nucleotide excision repair_Homo sapiens_hsa034201.50475097
48Phenylalanine metabolism_Homo sapiens_hsa003601.49362242
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.48162066
50Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.47080971
51Tyrosine metabolism_Homo sapiens_hsa003501.42762475
52* Steroid biosynthesis_Homo sapiens_hsa001001.41188982
53Pyruvate metabolism_Homo sapiens_hsa006201.38444437
54Cysteine and methionine metabolism_Homo sapiens_hsa002701.36137640
55Alzheimers disease_Homo sapiens_hsa050101.34736576
56RNA transport_Homo sapiens_hsa030131.33663520
57Spliceosome_Homo sapiens_hsa030401.30212689
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.24102737
59Starch and sucrose metabolism_Homo sapiens_hsa005001.22926225
60Bile secretion_Homo sapiens_hsa049761.22202666
61Biosynthesis of amino acids_Homo sapiens_hsa012301.21260474
62Carbon metabolism_Homo sapiens_hsa012001.20325449
63Vitamin B6 metabolism_Homo sapiens_hsa007501.18108179
64Sulfur relay system_Homo sapiens_hsa041221.15867907
65Fat digestion and absorption_Homo sapiens_hsa049751.13073499
66Cyanoamino acid metabolism_Homo sapiens_hsa004601.09900076
67Arginine and proline metabolism_Homo sapiens_hsa003301.07756112
68ABC transporters_Homo sapiens_hsa020101.07572823
69RNA degradation_Homo sapiens_hsa030181.06504076
70Cell cycle_Homo sapiens_hsa041101.02537956
71Basal transcription factors_Homo sapiens_hsa030221.01304054
72One carbon pool by folate_Homo sapiens_hsa006701.01042317
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.00508943
74Maturity onset diabetes of the young_Homo sapiens_hsa049500.99397262
75Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.99191675
76Vitamin digestion and absorption_Homo sapiens_hsa049770.97944130
77Glutathione metabolism_Homo sapiens_hsa004800.97365825
78Purine metabolism_Homo sapiens_hsa002300.89854681
79Pentose phosphate pathway_Homo sapiens_hsa000300.84455935
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68800070
81N-Glycan biosynthesis_Homo sapiens_hsa005100.64163032
82Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.61331997
83Cardiac muscle contraction_Homo sapiens_hsa042600.61005757
84* Metabolic pathways_Homo sapiens_hsa011000.60862875
85Glycerolipid metabolism_Homo sapiens_hsa005610.59072108
86Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.55856652
87Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.53874592
88Lysine degradation_Homo sapiens_hsa003100.52019458
89Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.45299359
90Fatty acid biosynthesis_Homo sapiens_hsa000610.43375749
91p53 signaling pathway_Homo sapiens_hsa041150.42889561
92Galactose metabolism_Homo sapiens_hsa000520.41595927
93Oocyte meiosis_Homo sapiens_hsa041140.38480388
94Fructose and mannose metabolism_Homo sapiens_hsa000510.37920403
95Linoleic acid metabolism_Homo sapiens_hsa005910.36676360
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36314673
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.36050681
98Proteasome_Homo sapiens_hsa030500.31074710
99Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.28241382
100mRNA surveillance pathway_Homo sapiens_hsa030150.24450895
101Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.24051845
102Prion diseases_Homo sapiens_hsa050200.23638496
103Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.18612365
104Protein export_Homo sapiens_hsa030600.17911498
105Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.17620100
106Glycerophospholipid metabolism_Homo sapiens_hsa005640.16305704
107Arachidonic acid metabolism_Homo sapiens_hsa005900.11303703
108Oxidative phosphorylation_Homo sapiens_hsa001900.10770023
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.10300369
110Pyrimidine metabolism_Homo sapiens_hsa002400.09621291
111Regulation of autophagy_Homo sapiens_hsa041400.07287524
112Insulin resistance_Homo sapiens_hsa049310.03809069
113Glycosaminoglycan degradation_Homo sapiens_hsa005310.03470713
114Lysosome_Homo sapiens_hsa041420.00659765
115Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1104819
116Ether lipid metabolism_Homo sapiens_hsa00565-0.1084413
117Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.1029726
118Hepatitis C_Homo sapiens_hsa05160-0.1001304
119Pertussis_Homo sapiens_hsa05133-0.0870931
120Legionellosis_Homo sapiens_hsa05134-0.0838840
121Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0577436
122Intestinal immune network for IgA production_Homo sapiens_hsa04672-0.0508419
123Other glycan degradation_Homo sapiens_hsa00511-0.0397795
124RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.0382456
125Renin-angiotensin system_Homo sapiens_hsa04614-0.0361412
126Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623-0.0191052
127Parkinsons disease_Homo sapiens_hsa05012-0.0152421

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