ECD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.02301992
2DNA strand elongation involved in DNA replication (GO:0006271)4.71654076
3maturation of SSU-rRNA (GO:0030490)4.64942635
4DNA replication initiation (GO:0006270)4.61481001
5DNA strand elongation (GO:0022616)4.59568475
6DNA unwinding involved in DNA replication (GO:0006268)4.53380526
7telomere maintenance via semi-conservative replication (GO:0032201)4.42991109
8ribosomal large subunit biogenesis (GO:0042273)4.39900237
9nucleobase biosynthetic process (GO:0046112)4.36623789
10mitotic metaphase plate congression (GO:0007080)4.17622879
11IMP biosynthetic process (GO:0006188)4.16298545
12DNA double-strand break processing (GO:0000729)4.15846372
13DNA replication checkpoint (GO:0000076)4.15104044
14folic acid-containing compound biosynthetic process (GO:0009396)4.03429070
15purine nucleobase biosynthetic process (GO:0009113)4.00404472
16DNA deamination (GO:0045006)3.94048062
17formation of translation preinitiation complex (GO:0001731)3.85415380
18viral transcription (GO:0019083)3.85297464
19telomere maintenance via recombination (GO:0000722)3.85128727
20ribonucleoprotein complex biogenesis (GO:0022613)3.84598092
21pseudouridine synthesis (GO:0001522)3.82698002
22ribosomal small subunit biogenesis (GO:0042274)3.79543200
23translational termination (GO:0006415)3.78700546
24CENP-A containing nucleosome assembly (GO:0034080)3.77756445
25telomere maintenance via telomere lengthening (GO:0010833)3.76323217
26negative regulation of DNA-dependent DNA replication (GO:2000104)3.76103803
27ribosome biogenesis (GO:0042254)3.72021231
28chromatin remodeling at centromere (GO:0031055)3.71141402
29protein localization to kinetochore (GO:0034501)3.70652860
30spliceosomal snRNP assembly (GO:0000387)3.70050285
31proteasome assembly (GO:0043248)3.68420465
32mitotic recombination (GO:0006312)3.68219168
33IMP metabolic process (GO:0046040)3.65246622
34water-soluble vitamin biosynthetic process (GO:0042364)3.62572389
35replication fork processing (GO:0031297)3.59082249
36rRNA processing (GO:0006364)3.59025630
37metaphase plate congression (GO:0051310)3.56943025
38translational elongation (GO:0006414)3.55916770
39cullin deneddylation (GO:0010388)3.55852988
40negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.55410881
41RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.52901529
42SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.51951704
43protein deneddylation (GO:0000338)3.49362485
44termination of RNA polymerase III transcription (GO:0006386)3.49136873
45transcription elongation from RNA polymerase III promoter (GO:0006385)3.49136873
46rRNA metabolic process (GO:0016072)3.48641525
47somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.48375197
48isotype switching (GO:0045190)3.48375197
49somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.48375197
50translational initiation (GO:0006413)3.48216766
51regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.47042403
52anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.46896983
53rRNA modification (GO:0000154)3.45574113
54mitotic nuclear envelope disassembly (GO:0007077)3.45178932
55protein-cofactor linkage (GO:0018065)3.45016689
56response to pheromone (GO:0019236)3.45005559
57cotranslational protein targeting to membrane (GO:0006613)3.44893311
58nucleotide-excision repair, DNA gap filling (GO:0006297)3.44294672
59deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.42181941
60regulation of nuclear cell cycle DNA replication (GO:0033262)3.40993581
61protein targeting to ER (GO:0045047)3.40887920
62mitochondrial RNA metabolic process (GO:0000959)3.40588844
63positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.38760600
64regulation of mitotic spindle checkpoint (GO:1903504)3.36526531
65regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.36526531
66synapsis (GO:0007129)3.35097625
67transcription-coupled nucleotide-excision repair (GO:0006283)3.33123744
68attachment of spindle microtubules to kinetochore (GO:0008608)3.32342430
69DNA replication-independent nucleosome assembly (GO:0006336)3.28204333
70DNA replication-independent nucleosome organization (GO:0034724)3.28204333
71mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.27232264
72establishment of chromosome localization (GO:0051303)3.26421674
73establishment of protein localization to mitochondrial membrane (GO:0090151)3.25555520
74regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.24832528
75establishment of integrated proviral latency (GO:0075713)3.23358892
76spliceosomal complex assembly (GO:0000245)3.23002293
77recombinational repair (GO:0000725)3.22800177
78double-strand break repair via homologous recombination (GO:0000724)3.22738412
79telomere maintenance via telomerase (GO:0007004)3.22080386
80protein localization to endoplasmic reticulum (GO:0070972)3.21754936
81establishment of protein localization to endoplasmic reticulum (GO:0072599)3.21508565
82exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.21066315
83DNA catabolic process, exonucleolytic (GO:0000738)3.20711487
84negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.20275289
85negative regulation of ligase activity (GO:0051352)3.20275289
86respiratory chain complex IV assembly (GO:0008535)3.19149239
87nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.18919214
88nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.18373602
89nuclear envelope disassembly (GO:0051081)3.17514178
90membrane disassembly (GO:0030397)3.17514178
91mitochondrial respiratory chain complex I assembly (GO:0032981)3.17333882
92NADH dehydrogenase complex assembly (GO:0010257)3.17333882
93mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.17333882
94regulation of centriole replication (GO:0046599)3.17319053
95protein localization to chromosome, centromeric region (GO:0071459)3.16023045
96intra-S DNA damage checkpoint (GO:0031573)3.15806114
97viral mRNA export from host cell nucleus (GO:0046784)3.13629937
98cellular component biogenesis (GO:0044085)3.12873889
99translation (GO:0006412)3.11398343
100mitochondrial respiratory chain complex assembly (GO:0033108)3.10877801
101regulation of double-strand break repair via homologous recombination (GO:0010569)3.08538735
102maturation of 5.8S rRNA (GO:0000460)3.08262115
103mitotic sister chromatid segregation (GO:0000070)3.06837975
104histone H2A acetylation (GO:0043968)3.05790736
105histone exchange (GO:0043486)3.05468497
106DNA replication-dependent nucleosome organization (GO:0034723)3.05113384
107DNA replication-dependent nucleosome assembly (GO:0006335)3.05113384
108cellular protein complex disassembly (GO:0043624)3.02839019
109protein complex biogenesis (GO:0070271)3.02398276
1107-methylguanosine mRNA capping (GO:0006370)3.02175398
111maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.01899702
112viral life cycle (GO:0019058)3.01113675
113G1/S transition of mitotic cell cycle (GO:0000082)3.00774972
114cell cycle G1/S phase transition (GO:0044843)3.00774972
115ribosome assembly (GO:0042255)3.00163373
116branched-chain amino acid catabolic process (GO:0009083)2.99855217
117kinetochore organization (GO:0051383)2.97939076
118tRNA methylation (GO:0030488)2.97729373
119peptidyl-histidine modification (GO:0018202)2.97621077
120somatic hypermutation of immunoglobulin genes (GO:0016446)2.97576579
121somatic diversification of immune receptors via somatic mutation (GO:0002566)2.97576579
1227-methylguanosine RNA capping (GO:0009452)2.97151038
123RNA capping (GO:0036260)2.97151038
124positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.96990561
125ncRNA processing (GO:0034470)2.95598504
126cellular ketone body metabolic process (GO:0046950)2.95547465
127ubiquinone biosynthetic process (GO:0006744)2.94802292
128rRNA methylation (GO:0031167)2.94682620
129DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.94101503
130intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.92375584
131signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.92375584
132ncRNA metabolic process (GO:0034660)2.92374742
133signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.91989228
134signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.91989228
135signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.91989228
136reciprocal DNA recombination (GO:0035825)2.91008017
137reciprocal meiotic recombination (GO:0007131)2.91008017
138ATP synthesis coupled proton transport (GO:0015986)2.89894279
139energy coupled proton transport, down electrochemical gradient (GO:0015985)2.89894279
140fucose catabolic process (GO:0019317)2.89421776
141L-fucose metabolic process (GO:0042354)2.89421776
142L-fucose catabolic process (GO:0042355)2.89421776
143single strand break repair (GO:0000012)2.88851047
144tRNA processing (GO:0008033)2.88386103
145protein K6-linked ubiquitination (GO:0085020)2.85494232
146L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.85066235
147somatic diversification of immunoglobulins (GO:0016445)2.84937256
148regulation of hexokinase activity (GO:1903299)2.84799284
149regulation of glucokinase activity (GO:0033131)2.84799284
150ubiquinone metabolic process (GO:0006743)2.83321797
151tRNA metabolic process (GO:0006399)2.82505677
152DNA-dependent DNA replication (GO:0006261)2.75982105
153somatic recombination of immunoglobulin gene segments (GO:0016447)2.70332405
154rRNA catabolic process (GO:0016075)2.70106874
155regulation of DNA endoreduplication (GO:0032875)2.69703141
156RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.69344812
157tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.69344812
158behavioral response to nicotine (GO:0035095)2.68959235
159tRNA modification (GO:0006400)2.68153770
160ketone body metabolic process (GO:1902224)2.67318869
161regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.65916158
162intracellular protein transmembrane import (GO:0044743)2.65398799
163regulation of cellular amino acid metabolic process (GO:0006521)2.60457543
164cytochrome complex assembly (GO:0017004)2.60454050
165centriole replication (GO:0007099)2.59490131
166lysine metabolic process (GO:0006553)2.58876747
167lysine catabolic process (GO:0006554)2.58876747
168RNA-dependent DNA replication (GO:0006278)2.58065157

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.20740923
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.40268652
3* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.91765959
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.65632061
5ZNF274_21170338_ChIP-Seq_K562_Hela3.65400521
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.56505516
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.51899251
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.48058406
9FOXM1_23109430_ChIP-Seq_U2OS_Human3.44068144
10* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.39969327
11* ETS1_20019798_ChIP-Seq_JURKAT_Human3.15298416
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.08656422
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.02740478
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.96603964
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.93834962
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.90988322
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.89802700
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.87802309
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.55649640
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.45938445
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.45425304
22* VDR_23849224_ChIP-Seq_CD4+_Human2.44138895
23VDR_22108803_ChIP-Seq_LS180_Human2.42035836
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.39227422
25* XRN2_22483619_ChIP-Seq_HELA_Human2.33762171
26FOXP3_21729870_ChIP-Seq_TREG_Human2.30980400
27SALL1_21062744_ChIP-ChIP_HESCs_Human2.30554062
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.26097872
29EWS_26573619_Chip-Seq_HEK293_Human2.24831838
30* DCP1A_22483619_ChIP-Seq_HELA_Human2.20330803
31* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.18126977
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.17768376
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.09054411
34POU3F2_20337985_ChIP-ChIP_501MEL_Human2.04478981
35* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.03645573
36FLI1_27457419_Chip-Seq_LIVER_Mouse2.03034770
37* GABP_19822575_ChIP-Seq_HepG2_Human2.00935003
38SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.98298680
39MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.95446305
40TTF2_22483619_ChIP-Seq_HELA_Human1.93249443
41FUS_26573619_Chip-Seq_HEK293_Human1.92140034
42* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.91626957
43SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.89998334
44AR_21909140_ChIP-Seq_LNCAP_Human1.89646981
45GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.86735606
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.84728069
47MYCN_18555785_ChIP-Seq_MESCs_Mouse1.84428879
48ELK1_19687146_ChIP-ChIP_HELA_Human1.81836817
49E2F1_21310950_ChIP-Seq_MCF-7_Human1.80996379
50HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.80785357
51SRF_21415370_ChIP-Seq_HL-1_Mouse1.79975923
52GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.74949703
53YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.72267630
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.70372355
55MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.68530840
56ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.68446362
57E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.68227468
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.63867031
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.63147587
60CIITA_25753668_ChIP-Seq_RAJI_Human1.63067847
61PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.59415815
62GBX2_23144817_ChIP-Seq_PC3_Human1.56062123
63KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.55687964
64ZFX_18555785_ChIP-Seq_MESCs_Mouse1.55368961
65ZFP57_27257070_Chip-Seq_ESCs_Mouse1.54404891
66IRF1_19129219_ChIP-ChIP_H3396_Human1.52629352
67FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.49999791
68ERG_20887958_ChIP-Seq_HPC-7_Mouse1.47400925
69* KDM5A_27292631_Chip-Seq_BREAST_Human1.45823234
70NANOG_18555785_ChIP-Seq_MESCs_Mouse1.45157828
71FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.44494848
72RBPJ_22232070_ChIP-Seq_NCS_Mouse1.44029383
73P300_19829295_ChIP-Seq_ESCs_Human1.43353393
74SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.42572754
75PCGF2_27294783_Chip-Seq_ESCs_Mouse1.42203644
76NOTCH1_21737748_ChIP-Seq_TLL_Human1.38875085
77IGF1R_20145208_ChIP-Seq_DFB_Human1.37636563
78PADI4_21655091_ChIP-ChIP_MCF-7_Human1.37130078
79* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.34184157
80CTBP2_25329375_ChIP-Seq_LNCAP_Human1.30498500
81* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.30468640
82TP53_22573176_ChIP-Seq_HFKS_Human1.30194437
83ER_23166858_ChIP-Seq_MCF-7_Human1.27123857
84TAF15_26573619_Chip-Seq_HEK293_Human1.26441478
85EGR1_19374776_ChIP-ChIP_THP-1_Human1.19488475
86MYC_18940864_ChIP-ChIP_HL60_Human1.19429483
87* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19156593
88CTBP1_25329375_ChIP-Seq_LNCAP_Human1.18872957
89MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.17427525
90SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.15203255
91ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15057551
92POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.13172723
93TFEB_21752829_ChIP-Seq_HELA_Human1.11742195
94MYC_22102868_ChIP-Seq_BL_Human1.07630481
95TP63_19390658_ChIP-ChIP_HaCaT_Human1.07420091
96ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.05801479
97POU5F1_16153702_ChIP-ChIP_HESCs_Human1.05755504
98FOXA1_27270436_Chip-Seq_PROSTATE_Human1.05721454
99FOXA1_25329375_ChIP-Seq_VCAP_Human1.05721454
100* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.05552285
101BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.05535861
102AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05437868
103KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03007995
104IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02329564
105CBP_20019798_ChIP-Seq_JUKART_Human1.02329564
106GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01868639
107DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.00603198
108SOX2_16153702_ChIP-ChIP_HESCs_Human0.98210162
109ELK1_22589737_ChIP-Seq_MCF10A_Human0.97660168
110EZH2_27294783_Chip-Seq_NPCs_Mouse0.97574184
111NANOG_19829295_ChIP-Seq_ESCs_Human0.97485027
112SOX2_19829295_ChIP-Seq_ESCs_Human0.97485027
113NANOG_16153702_ChIP-ChIP_HESCs_Human0.97338279
114CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96847171
115* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95371321
116UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94669365
117CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.94472524
118AR_20517297_ChIP-Seq_VCAP_Human0.93957658
119MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93852817
120GATA1_22025678_ChIP-Seq_K562_Human0.93212645
121NFE2_27457419_Chip-Seq_LIVER_Mouse0.92701667
122RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.92071557
123SUZ12_27294783_Chip-Seq_NPCs_Mouse0.91629145
124DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.91026330
125CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.89767739
126HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.89086026
127GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.88203303
128STAT3_1855785_ChIP-Seq_MESCs_Mouse0.87424492
129CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.86681939
130SPI1_23547873_ChIP-Seq_NB4_Human0.86459905
131STAT3_23295773_ChIP-Seq_U87_Human0.86398153
132* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.85963737
133CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85858877
134POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.85668792
135EGR1_23403033_ChIP-Seq_LIVER_Mouse0.84445762
136CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.84369581
137PCGF2_27294783_Chip-Seq_NPCs_Mouse0.83467309
138HOXB7_26014856_ChIP-Seq_BT474_Human0.82777629
139KLF5_20875108_ChIP-Seq_MESCs_Mouse0.82318662
140SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.82016673
141IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.77176992
142* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.76956345
143* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76102020
144TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.72920885
145HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.72793702
146SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.70476907
147NANOG_21062744_ChIP-ChIP_HESCs_Human0.69602493
148CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.69452522
149SOX17_20123909_ChIP-Seq_XEN_Mouse0.67976475

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.26483446
2MP0010094_abnormal_chromosome_stability4.68525489
3MP0004957_abnormal_blastocyst_morpholog4.65871167
4MP0003111_abnormal_nucleus_morphology4.29352968
5MP0008057_abnormal_DNA_replication4.02779318
6MP0003077_abnormal_cell_cycle3.98230838
7MP0008058_abnormal_DNA_repair3.89979017
8MP0003195_calcinosis3.30042451
9MP0008007_abnormal_cellular_replicative3.18683084
10MP0008932_abnormal_embryonic_tissue2.90546621
11MP0000569_abnormal_digit_pigmentation2.84610455
12MP0009379_abnormal_foot_pigmentation2.77961609
13MP0002396_abnormal_hematopoietic_system2.26353089
14MP0008877_abnormal_DNA_methylation2.20030081
15MP0003786_premature_aging2.17305572
16MP0001730_embryonic_growth_arrest2.10401277
17MP0003718_maternal_effect2.01057284
18MP0006072_abnormal_retinal_apoptosis2.00073790
19MP0006292_abnormal_olfactory_placode1.98062669
20MP0003123_paternal_imprinting1.97512195
21MP0000350_abnormal_cell_proliferation1.95497737
22MP0002132_abnormal_respiratory_system1.73657100
23MP0000490_abnormal_crypts_of1.72658882
24MP0010030_abnormal_orbit_morphology1.69029484
25MP0005084_abnormal_gallbladder_morpholo1.59496637
26MP0009046_muscle_twitch1.56711633
27MP0003763_abnormal_thymus_physiology1.56108672
28MP0003787_abnormal_imprinting1.53829129
29MP0008875_abnormal_xenobiotic_pharmacok1.53307910
30MP0005551_abnormal_eye_electrophysiolog1.53239718
31MP0001697_abnormal_embryo_size1.50441584
32MP0002160_abnormal_reproductive_system1.45496334
33MP0002254_reproductive_system_inflammat1.45052208
34MP0000647_abnormal_sebaceous_gland1.45051659
35MP0000427_abnormal_hair_cycle1.44593218
36MP0005380_embryogenesis_phenotype1.44110172
37MP0001672_abnormal_embryogenesis/_devel1.44110172
38MP0001188_hyperpigmentation1.42360821
39MP0002080_prenatal_lethality1.39678202
40MP0005253_abnormal_eye_physiology1.38998318
41MP0000313_abnormal_cell_death1.38576281
42MP0010352_gastrointestinal_tract_polyps1.38562574
43MP0005645_abnormal_hypothalamus_physiol1.37367309
44MP0005075_abnormal_melanosome_morpholog1.36540550
45MP0001919_abnormal_reproductive_system1.33925927
46MP0002019_abnormal_tumor_incidence1.32807852
47MP0002210_abnormal_sex_determination1.32218210
48MP0003806_abnormal_nucleotide_metabolis1.31800714
49MP0003315_abnormal_perineum_morphology1.31014497
50MP0002837_dystrophic_cardiac_calcinosis1.29369263
51MP0003950_abnormal_plasma_membrane1.28003839
52MP0009333_abnormal_splenocyte_physiolog1.27984807
53MP0002234_abnormal_pharynx_morphology1.27313435
54MP0005389_reproductive_system_phenotype1.27271699
55MP0008872_abnormal_physiological_respon1.26533035
56MP0003984_embryonic_growth_retardation1.26322168
57MP0002085_abnormal_embryonic_tissue1.24182749
58MP0002088_abnormal_embryonic_growth/wei1.22434607
59MP0008995_early_reproductive_senescence1.22099773
60MP0004142_abnormal_muscle_tone1.20567343
61MP0000678_abnormal_parathyroid_gland1.20278546
62MP0002736_abnormal_nociception_after1.19860715
63MP0004215_abnormal_myocardial_fiber1.19539184
64MP0004808_abnormal_hematopoietic_stem1.19357481
65MP0009697_abnormal_copulation1.14712566
66MP0003890_abnormal_embryonic-extraembry1.13944336
67MP0000703_abnormal_thymus_morphology1.12101276
68MP0001145_abnormal_male_reproductive1.10434278
69MP0003011_delayed_dark_adaptation1.09978902
70MP0006035_abnormal_mitochondrial_morpho1.09713430
71MP0003937_abnormal_limbs/digits/tail_de1.09349535
72MP0001293_anophthalmia1.08220744
73MP0006036_abnormal_mitochondrial_physio1.07949149
74MP0000358_abnormal_cell_content/1.07595726
75MP0001929_abnormal_gametogenesis1.07253556
76MP0002163_abnormal_gland_morphology1.06541193
77MP0002084_abnormal_developmental_patter1.06453120
78MP0001529_abnormal_vocalization1.05432935
79MP0000689_abnormal_spleen_morphology1.05023266
80MP0003567_abnormal_fetal_cardiomyocyte1.04804931
81MP0002398_abnormal_bone_marrow1.04329061
82MP0000566_synostosis1.03527976
83MP0003121_genomic_imprinting1.03132929
84MP0004133_heterotaxia1.02821733
85MP0004147_increased_porphyrin_level1.02057062
86MP0002722_abnormal_immune_system1.02054149
87MP0001968_abnormal_touch/_nociception1.00943664
88MP0001986_abnormal_taste_sensitivity1.00792586
89MP0003646_muscle_fatigue0.99626962
90MP0005410_abnormal_fertilization0.98799784
91MP0000653_abnormal_sex_gland0.98390046
92MP0000015_abnormal_ear_pigmentation0.97596571
93MP0005174_abnormal_tail_pigmentation0.96896147
94MP0003186_abnormal_redox_activity0.96679469
95MP0000631_abnormal_neuroendocrine_gland0.96099130
96MP0001119_abnormal_female_reproductive0.95649706
97MP0002277_abnormal_respiratory_mucosa0.95068694
98MP0005408_hypopigmentation0.94497064
99MP0003136_yellow_coat_color0.94446587
100MP0002086_abnormal_extraembryonic_tissu0.93351568
101MP0002095_abnormal_skin_pigmentation0.92740072
102MP0002102_abnormal_ear_morphology0.92558571
103MP0001853_heart_inflammation0.92030416
104MP0005395_other_phenotype0.91192670
105MP0001764_abnormal_homeostasis0.87376939
106MP0003698_abnormal_male_reproductive0.87372489
107MP0000372_irregular_coat_pigmentation0.86967242
108MP0005266_abnormal_metabolism0.86860849
109MP0006054_spinal_hemorrhage0.86123346
110MP0004043_abnormal_pH_regulation0.85986375
111MP0005332_abnormal_amino_acid0.83568333
112MP0010307_abnormal_tumor_latency0.81881538
113MP0004145_abnormal_muscle_electrophysio0.81567930
114MP0004197_abnormal_fetal_growth/weight/0.81096223
115MP0002429_abnormal_blood_cell0.80474231
116MP0000858_altered_metastatic_potential0.80154499
117MP0010386_abnormal_urinary_bladder0.79978388
118MP0002138_abnormal_hepatobiliary_system0.79681421
119MP0001485_abnormal_pinna_reflex0.79596121
120MP0002876_abnormal_thyroid_physiology0.79057552
121MP0000383_abnormal_hair_follicle0.77056110
122MP0002751_abnormal_autonomic_nervous0.76669365
123MP0005379_endocrine/exocrine_gland_phen0.74653698
124MP0008789_abnormal_olfactory_epithelium0.74647559
125MP0000049_abnormal_middle_ear0.74608347
126MP0009672_abnormal_birth_weight0.74217651
127MP0005367_renal/urinary_system_phenotyp0.72439815
128MP0000516_abnormal_urinary_system0.72439815
129MP0002638_abnormal_pupillary_reflex0.71906834
130MP0003880_abnormal_central_pattern0.71602689
131MP0002938_white_spotting0.71512987
132MP0005671_abnormal_response_to0.70294936
133MP0002272_abnormal_nervous_system0.69831050
134MP0003137_abnormal_impulse_conducting0.69691496
135MP0001324_abnormal_eye_pigmentation0.68539699
136MP0008260_abnormal_autophagy0.68511874
137MP0005409_darkened_coat_color0.67632643
138MP0002075_abnormal_coat/hair_pigmentati0.67488202
139MP0003119_abnormal_digestive_system0.67461902
140MP0003941_abnormal_skin_development0.66134789
141MP0000537_abnormal_urethra_morphology0.64518147
142MP0002111_abnormal_tail_morphology0.64184393
143MP0001186_pigmentation_phenotype0.64098769
144MP0000716_abnormal_immune_system0.62139742
145MP0005384_cellular_phenotype0.62039460
146MP0002653_abnormal_ependyma_morphology0.61108377
147MP0005220_abnormal_exocrine_pancreas0.60180511
148MP0005397_hematopoietic_system_phenotyp0.60168843
149MP0001545_abnormal_hematopoietic_system0.60168843

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.55668006
2Reticulocytopenia (HP:0001896)4.29452641
3Abnormality of cells of the erythroid lineage (HP:0012130)4.18107696
4Abnormal number of erythroid precursors (HP:0012131)3.93217275
5Microvesicular hepatic steatosis (HP:0001414)3.62470550
6Chromsome breakage (HP:0040012)3.35786409
7Oral leukoplakia (HP:0002745)3.28637225
8Abnormality of the preputium (HP:0100587)3.27821315
9Abnormality of alanine metabolism (HP:0010916)3.22257799
10Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.22257799
11Macrocytic anemia (HP:0001972)3.16627742
1211 pairs of ribs (HP:0000878)3.15373943
13Degeneration of anterior horn cells (HP:0002398)3.13952269
14Abnormality of the anterior horn cell (HP:0006802)3.13952269
15Molar tooth sign on MRI (HP:0002419)3.13847093
16Abnormality of midbrain morphology (HP:0002418)3.13847093
17Breast hypoplasia (HP:0003187)3.12330153
18Chromosomal breakage induced by crosslinking agents (HP:0003221)3.08086265
19Aplasia/Hypoplasia of the sacrum (HP:0008517)3.06230124
20Absent thumb (HP:0009777)3.04699223
21Cerebral hypomyelination (HP:0006808)3.02505542
22Abnormality of chromosome stability (HP:0003220)2.98902988
23Meckel diverticulum (HP:0002245)2.95990576
24Pallor (HP:0000980)2.94880906
25Aplastic anemia (HP:0001915)2.93952874
26Colon cancer (HP:0003003)2.91520991
27Nephronophthisis (HP:0000090)2.89072599
28Aplasia/Hypoplasia of the uvula (HP:0010293)2.86189981
29Large for gestational age (HP:0001520)2.85598209
30Rough bone trabeculation (HP:0100670)2.84305285
31Type I transferrin isoform profile (HP:0003642)2.83582876
32Abnormality of the ileum (HP:0001549)2.82313673
33Patellar aplasia (HP:0006443)2.76779059
34Acute encephalopathy (HP:0006846)2.67892636
35Hepatocellular necrosis (HP:0001404)2.67554080
36Methylmalonic acidemia (HP:0002912)2.66192333
37Increased serum lactate (HP:0002151)2.64970348
38Progressive inability to walk (HP:0002505)2.63768554
39Bone marrow hypocellularity (HP:0005528)2.62739847
40Abnormality of the pons (HP:0007361)2.59726844
41Selective tooth agenesis (HP:0001592)2.56385547
42Abnormality of the renal cortex (HP:0011035)2.56140164
43Increased serum pyruvate (HP:0003542)2.55825882
44Abnormality of glycolysis (HP:0004366)2.55825882
45Pendular nystagmus (HP:0012043)2.55724933
46Aplasia/Hypoplasia of the patella (HP:0006498)2.55721837
47Abnormality of the labia minora (HP:0012880)2.54522238
48Chronic hepatic failure (HP:0100626)2.50552856
49Myelodysplasia (HP:0002863)2.50374617
50Abnormal lung lobation (HP:0002101)2.48951959
51Duodenal stenosis (HP:0100867)2.46349789
52Small intestinal stenosis (HP:0012848)2.46349789
53Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.45050823
54Decreased activity of mitochondrial respiratory chain (HP:0008972)2.45050823
55Medial flaring of the eyebrow (HP:0010747)2.42740657
56Agnosia (HP:0010524)2.42266804
57Increased CSF lactate (HP:0002490)2.39698388
58Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.39633861
59Abnormal protein N-linked glycosylation (HP:0012347)2.39633861
60Abnormal protein glycosylation (HP:0012346)2.39633861
61Abnormal glycosylation (HP:0012345)2.39633861
62Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.39254157
63Medulloblastoma (HP:0002885)2.37980154
64Abnormality of methionine metabolism (HP:0010901)2.37402862
65Hepatic necrosis (HP:0002605)2.37214208
66Abnormality of the renal medulla (HP:0100957)2.35541293
67Pancreatic islet-cell hyperplasia (HP:0004510)2.35515811
68Impulsivity (HP:0100710)2.34730515
69Sloping forehead (HP:0000340)2.34116630
70Triphalangeal thumb (HP:0001199)2.33985896
71Premature graying of hair (HP:0002216)2.33606569
72Dry hair (HP:0011359)2.32447556
73Mitochondrial inheritance (HP:0001427)2.31790542
74Microretrognathia (HP:0000308)2.31129882
75Renal cortical cysts (HP:0000803)2.30359829
76Methylmalonic aciduria (HP:0012120)2.29241750
77Increased hepatocellular lipid droplets (HP:0006565)2.28483075
78Pancytopenia (HP:0001876)2.25993437
79Inability to walk (HP:0002540)2.25894701
80Progressive macrocephaly (HP:0004481)2.24755682
81Horseshoe kidney (HP:0000085)2.24237701
82Hypoplasia of the pons (HP:0012110)2.22565531
83Bile duct proliferation (HP:0001408)2.21297844
84Abnormal biliary tract physiology (HP:0012439)2.21297844
85Abnormality of aspartate family amino acid metabolism (HP:0010899)2.19909900
86Cellular immunodeficiency (HP:0005374)2.19528995
87Sclerocornea (HP:0000647)2.18273477
88Supernumerary spleens (HP:0009799)2.17907580
89Progressive muscle weakness (HP:0003323)2.17508544
90Ketoacidosis (HP:0001993)2.17259893
91Lactic acidosis (HP:0003128)2.16977074
92Hypothermia (HP:0002045)2.14672571
93Trismus (HP:0000211)2.13972429
94Lipid accumulation in hepatocytes (HP:0006561)2.11536166
95Neoplasm of the pancreas (HP:0002894)2.10025800
96Tubular atrophy (HP:0000092)2.09696903
97Secondary amenorrhea (HP:0000869)2.09588476
98Hypoplasia of the capital femoral epiphysis (HP:0003090)2.09431641
99Abnormality of pyrimidine metabolism (HP:0004353)2.09262101
100Reduced antithrombin III activity (HP:0001976)2.07673269
101Acute necrotizing encephalopathy (HP:0006965)2.06639281
102Congenital stationary night blindness (HP:0007642)2.06579391
103Abolished electroretinogram (ERG) (HP:0000550)2.05486602
104Abnormality of the duodenum (HP:0002246)2.05061910
105Abnormality of the heme biosynthetic pathway (HP:0010472)2.04860382
106Abnormality of serum amino acid levels (HP:0003112)2.04671239
107Abnormal number of incisors (HP:0011064)2.03834906
108Ectopic kidney (HP:0000086)2.03468407
109Facial cleft (HP:0002006)2.02595305
110Respiratory difficulties (HP:0002880)2.01813225
111Muscle fiber atrophy (HP:0100295)2.01689784
112Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.01448334
113Exertional dyspnea (HP:0002875)2.01015418
114Abnormal trabecular bone morphology (HP:0100671)2.00666674
115Attenuation of retinal blood vessels (HP:0007843)1.99849914
116Congenital, generalized hypertrichosis (HP:0004540)1.99590626
117Rhabdomyosarcoma (HP:0002859)1.98996329
118True hermaphroditism (HP:0010459)1.98874850
119Exercise intolerance (HP:0003546)1.96862388
1203-Methylglutaconic aciduria (HP:0003535)1.96399843
121Pancreatic fibrosis (HP:0100732)1.95160062
122Carpal bone hypoplasia (HP:0001498)1.94410648
123Aplasia/Hypoplasia of the sternum (HP:0006714)1.94173261
124Cerebral edema (HP:0002181)1.93908628
125Type 2 muscle fiber atrophy (HP:0003554)1.93607899
126Type II lissencephaly (HP:0007260)1.92767333
127IgM deficiency (HP:0002850)1.92554224
128Abnormal mitochondria in muscle tissue (HP:0008316)1.92543695
129Basal cell carcinoma (HP:0002671)1.92391926
130Absent radius (HP:0003974)1.90559763
131Aplasia/hypoplasia of the uterus (HP:0008684)1.90168244
132Sparse eyelashes (HP:0000653)1.87903531
133Short middle phalanx of the 5th finger (HP:0004220)1.87834816
134Hypoplasia of the radius (HP:0002984)1.87747829
135Furrowed tongue (HP:0000221)1.86785891
136Cleft eyelid (HP:0000625)1.85329364
137Prominent metopic ridge (HP:0005487)1.83672416
138Pancreatic cysts (HP:0001737)1.83639745
139Optic disc pallor (HP:0000543)1.83422012
140Aplasia/Hypoplasia of the tibia (HP:0005772)1.83005188
141Hyperalaninemia (HP:0003348)1.82948640
142Congenital primary aphakia (HP:0007707)1.81236202
143Abnormality of the carotid arteries (HP:0005344)1.80238104
144Cystic liver disease (HP:0006706)1.80091697
145Hyperinsulinemic hypoglycemia (HP:0000825)1.79229839
146Aplasia/Hypoplasia of the tongue (HP:0010295)1.78932445
147Small hand (HP:0200055)1.78223318
148Ketosis (HP:0001946)1.78173745
149Lethargy (HP:0001254)1.77294378
150Hyperglycinuria (HP:0003108)1.76826089
151Renal Fanconi syndrome (HP:0001994)1.73234516
152Homocystinuria (HP:0002156)1.73126985
153Abnormality of homocysteine metabolism (HP:0010919)1.73126985
154Dandy-Walker malformation (HP:0001305)1.73085955
155Clubbing of toes (HP:0100760)1.72678758
156Gait imbalance (HP:0002141)1.72670398
157Nephrogenic diabetes insipidus (HP:0009806)1.72263492
158Poor head control (HP:0002421)1.70552960
159Volvulus (HP:0002580)1.70357635
160Chorioretinal atrophy (HP:0000533)1.69532145
161Gaze-evoked nystagmus (HP:0000640)1.69375294
162Oculomotor apraxia (HP:0000657)1.66408896

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.41796008
2EIF2AK14.47055442
3CDC73.46476032
4STK163.45827029
5WEE13.45288992
6BMPR1B3.01369639
7TLK12.94697449
8FRK2.76556796
9MAP4K22.62179790
10SRPK12.56728362
11NUAK12.55179931
12PLK42.45859948
13EIF2AK32.45820921
14TSSK62.41891619
15VRK12.30903963
16WNK32.22844745
17PASK2.10560887
18NME22.08354038
19TRIM282.06756724
20BRSK22.02073840
21INSRR1.98626527
22MKNK11.91737321
23PNCK1.87522354
24TTK1.82187600
25MKNK21.81580972
26PLK11.77356771
27TNIK1.69428130
28DYRK31.69355314
29BRSK11.60712317
30NME11.59677573
31VRK21.56791989
32NEK21.55449599
33PLK31.50361015
34ACVR1B1.44529091
35CDK71.40999881
36ATR1.37497513
37AURKB1.37230434
38AURKA1.34542070
39BCKDK1.32710702
40TESK21.32528627
41RPS6KA41.28497216
42WNK41.27910203
43PBK1.27545659
44FLT31.26516155
45IRAK31.23778782
46ZAK1.21631317
47OXSR11.17222037
48CDK81.16986542
49RPS6KB21.16547118
50CCNB11.14798452
51NEK11.09676970
52BRAF1.09015659
53GRK11.04380561
54CAMKK21.03558988
55MAP3K41.02562362
56CHEK21.00891360
57BCR1.00207352
58TGFBR10.95237967
59STK100.94601676
60MAP3K80.92725636
61CHEK10.91124313
62MAP4K10.89833620
63BLK0.88215448
64CDK40.87619031
65PINK10.86380562
66CSNK1G30.85112678
67CSNK1G10.84553621
68STK38L0.84288698
69TEC0.82762902
70TAOK30.82342110
71EIF2AK20.81656459
72CSNK1A1L0.76109521
73STK390.75982535
74CSNK1G20.74498121
75PIK3CG0.74395409
76ERBB30.72900343
77CSNK2A10.71441204
78PDK20.70631093
79CSNK2A20.70438495
80STK30.70233150
81ATM0.70175691
82EPHA20.70069995
83TAF10.69755622
84STK240.69696962
85PLK20.68422616
86MAPK130.67280667
87NLK0.66444552
88PIM20.65520518
89NEK90.64829564
90CDK20.64681655
91MAP3K120.64371671
92BTK0.64234618
93TXK0.61453676
94MELK0.61352681
95IRAK10.59739546
96ADRBK20.58076100
97STK40.57910013
98MAP2K70.54166100
99PAK30.53871490
100EPHA30.53427797
101PIM10.52545147
102PAK40.52169717
103PRKCE0.50996802
104PAK10.49511413
105IRAK40.48402191
106YES10.48383112
107CASK0.47634716
108TIE10.46830517
109CDK10.45538577
110AKT30.45509452
111SIK30.45081247
112KDR0.43418597
113ADRBK10.42125630
114RPS6KA50.40434869
115PRKCI0.40324468
116IKBKB0.40092288
117MAPKAPK50.39460059
118BRD40.39037256
119KIT0.38783504
120GRK60.37883641
121PHKG20.36313577
122PHKG10.36313577
123ZAP700.36267874
124CLK10.35694591
125PIK3CA0.34944968
126PRKCG0.34702861
127MAPKAPK30.33228644
128CDK120.32921625
129PDK40.32613445
130PDK30.32613445
131ERBB40.32182616
132CDK30.31149083
133CSNK1E0.29960935
134BMPR20.28832140
135LYN0.28743186
136CAMK1D0.28211815
137EEF2K0.27733855
138JAK30.27356009
139DYRK20.25292610
140MAP3K110.24427226
141TAOK20.23803145
142RPS6KB10.22706400
143MST40.21726804
144SCYL20.21110113
145CDK190.20579971
146RPS6KC10.20396380
147RPS6KL10.20396380
148RPS6KA60.18230673

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.73580727
2Mismatch repair_Homo sapiens_hsa034303.97461756
3Ribosome_Homo sapiens_hsa030103.75274460
4Proteasome_Homo sapiens_hsa030503.65082204
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.60977293
6RNA polymerase_Homo sapiens_hsa030203.57697548
7Homologous recombination_Homo sapiens_hsa034403.22773767
8Spliceosome_Homo sapiens_hsa030403.07389497
9RNA transport_Homo sapiens_hsa030132.92634827
10One carbon pool by folate_Homo sapiens_hsa006702.88228845
11Nucleotide excision repair_Homo sapiens_hsa034202.87142554
12Base excision repair_Homo sapiens_hsa034102.84916998
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.71551138
14Pyrimidine metabolism_Homo sapiens_hsa002402.64903077
15Non-homologous end-joining_Homo sapiens_hsa034502.54764787
16Cell cycle_Homo sapiens_hsa041102.43824326
17Fanconi anemia pathway_Homo sapiens_hsa034602.39734305
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.23946919
19Basal transcription factors_Homo sapiens_hsa030222.19813660
20Propanoate metabolism_Homo sapiens_hsa006402.09321524
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.08878561
22RNA degradation_Homo sapiens_hsa030181.95226381
23Protein export_Homo sapiens_hsa030601.82726593
24Butanoate metabolism_Homo sapiens_hsa006501.69556861
25Purine metabolism_Homo sapiens_hsa002301.57710725
26mRNA surveillance pathway_Homo sapiens_hsa030151.42664543
27Caffeine metabolism_Homo sapiens_hsa002321.39368404
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.31020537
29Steroid biosynthesis_Homo sapiens_hsa001001.29273998
30Phototransduction_Homo sapiens_hsa047441.27398398
31Nitrogen metabolism_Homo sapiens_hsa009101.26061159
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.24151352
33p53 signaling pathway_Homo sapiens_hsa041151.22069420
34Fatty acid elongation_Homo sapiens_hsa000621.20934557
35Vitamin B6 metabolism_Homo sapiens_hsa007501.19431707
36Tryptophan metabolism_Homo sapiens_hsa003801.17365597
37Epstein-Barr virus infection_Homo sapiens_hsa051691.12641906
38Peroxisome_Homo sapiens_hsa041461.06394923
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.05729198
40Folate biosynthesis_Homo sapiens_hsa007901.05070499
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.98292356
42Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.98241672
43Parkinsons disease_Homo sapiens_hsa050120.93814740
44Biosynthesis of amino acids_Homo sapiens_hsa012300.93157714
45Pentose phosphate pathway_Homo sapiens_hsa000300.92773817
46Huntingtons disease_Homo sapiens_hsa050160.91626404
47Systemic lupus erythematosus_Homo sapiens_hsa053220.90192517
48Sulfur relay system_Homo sapiens_hsa041220.88765247
49Oxidative phosphorylation_Homo sapiens_hsa001900.85973269
50Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.85179941
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.83654338
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.82597476
53Antigen processing and presentation_Homo sapiens_hsa046120.81181123
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80545734
55Drug metabolism - other enzymes_Homo sapiens_hsa009830.79449558
56Selenocompound metabolism_Homo sapiens_hsa004500.78630123
57Sulfur metabolism_Homo sapiens_hsa009200.77966277
58Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77380714
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.76373964
60Herpes simplex infection_Homo sapiens_hsa051680.75464329
61Cyanoamino acid metabolism_Homo sapiens_hsa004600.72218424
62Ether lipid metabolism_Homo sapiens_hsa005650.70477001
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.68859481
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.67007802
65Oocyte meiosis_Homo sapiens_hsa041140.65547833
66Viral carcinogenesis_Homo sapiens_hsa052030.65235213
67N-Glycan biosynthesis_Homo sapiens_hsa005100.63635788
68Carbon metabolism_Homo sapiens_hsa012000.61529717
69Vitamin digestion and absorption_Homo sapiens_hsa049770.59333896
70Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58971303
71Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.58892335
72Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56949357
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54785940
74Taste transduction_Homo sapiens_hsa047420.52877514
75Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50829324
76Primary immunodeficiency_Homo sapiens_hsa053400.50515323
77Fatty acid metabolism_Homo sapiens_hsa012120.49701226
78Maturity onset diabetes of the young_Homo sapiens_hsa049500.49293400
79Thyroid cancer_Homo sapiens_hsa052160.48922375
802-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48834324
81Fructose and mannose metabolism_Homo sapiens_hsa000510.48686555
82HTLV-I infection_Homo sapiens_hsa051660.47677537
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47160469
84Cardiac muscle contraction_Homo sapiens_hsa042600.47058120
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45753912
86Legionellosis_Homo sapiens_hsa051340.45306180
87Metabolic pathways_Homo sapiens_hsa011000.44029532
88Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.43964971
89Nicotine addiction_Homo sapiens_hsa050330.43797367
90Glutathione metabolism_Homo sapiens_hsa004800.43751698
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43424631
92beta-Alanine metabolism_Homo sapiens_hsa004100.42963532
93Chemical carcinogenesis_Homo sapiens_hsa052040.41346163
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39664772
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37639188
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37578525
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.36718411
98Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35578269
99Measles_Homo sapiens_hsa051620.35114212
100Fatty acid degradation_Homo sapiens_hsa000710.33647167
101Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.32614779
102Alcoholism_Homo sapiens_hsa050340.31085786
103Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.30978511
104Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.30028456
105Olfactory transduction_Homo sapiens_hsa047400.29578380
106Alzheimers disease_Homo sapiens_hsa050100.29255170
107Retinol metabolism_Homo sapiens_hsa008300.27449913
108Galactose metabolism_Homo sapiens_hsa000520.27004136
109Circadian rhythm_Homo sapiens_hsa047100.25528375
110Arachidonic acid metabolism_Homo sapiens_hsa005900.24993156
111Transcriptional misregulation in cancer_Homo sapiens_hsa052020.24971665
112Other glycan degradation_Homo sapiens_hsa005110.24023823
113Collecting duct acid secretion_Homo sapiens_hsa049660.22590276
114Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.20982612
115Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.20661198
116Apoptosis_Homo sapiens_hsa042100.20404521
117Regulation of autophagy_Homo sapiens_hsa041400.20111817
118Fatty acid biosynthesis_Homo sapiens_hsa000610.19140536
119Hepatitis B_Homo sapiens_hsa051610.16727765
120Pyruvate metabolism_Homo sapiens_hsa006200.16704123
121Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.14467946
122Type I diabetes mellitus_Homo sapiens_hsa049400.13415754
123NF-kappa B signaling pathway_Homo sapiens_hsa040640.13131574
124Hematopoietic cell lineage_Homo sapiens_hsa046400.12017957
125Arginine and proline metabolism_Homo sapiens_hsa003300.11178395
126Influenza A_Homo sapiens_hsa051640.11084731
127Intestinal immune network for IgA production_Homo sapiens_hsa046720.09791145
128MicroRNAs in cancer_Homo sapiens_hsa052060.08508303
129HIF-1 signaling pathway_Homo sapiens_hsa040660.07593577
130Small cell lung cancer_Homo sapiens_hsa052220.05980937
131Basal cell carcinoma_Homo sapiens_hsa052170.05699707
132Colorectal cancer_Homo sapiens_hsa052100.05192703
133Acute myeloid leukemia_Homo sapiens_hsa052210.04173171
134Linoleic acid metabolism_Homo sapiens_hsa005910.03862921
135Notch signaling pathway_Homo sapiens_hsa043300.03593065
136Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.01638046
137Shigellosis_Homo sapiens_hsa051310.00377299
138Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0379418
139TGF-beta signaling pathway_Homo sapiens_hsa04350-0.0370389
140RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.0241437
141Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650-0.0124628

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