ECE2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the M13 family, which includes type 2 integral membrane metallopeptidases. The encoded enzyme is a membrane-bound zinc-dependent metalloprotease. The enzyme catalyzes the cleavage of big endothelin to produce the vasoconstrictor endothelin-1, and plays a role in the processing of several neuroendocrine peptides. It may also have methyltransferase activity. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.70554000
2ribosomal small subunit assembly (GO:0000028)5.13941346
3establishment of protein localization to mitochondrial membrane (GO:0090151)4.99014984
4energy coupled proton transport, down electrochemical gradient (GO:0015985)4.90760679
5ATP synthesis coupled proton transport (GO:0015986)4.90760679
6mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.54620373
72-deoxyribonucleotide biosynthetic process (GO:0009265)4.51264910
8deoxyribose phosphate biosynthetic process (GO:0046385)4.51264910
9respiratory electron transport chain (GO:0022904)4.36597568
10electron transport chain (GO:0022900)4.27406294
11deoxyribonucleotide biosynthetic process (GO:0009263)4.10238249
12pseudouridine synthesis (GO:0001522)4.05645132
13nucleobase biosynthetic process (GO:0046112)4.02898895
14deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.98606937
15chaperone-mediated protein transport (GO:0072321)3.98550750
16purine nucleobase biosynthetic process (GO:0009113)3.93712221
17protein complex biogenesis (GO:0070271)3.85155898
18mitochondrial respiratory chain complex assembly (GO:0033108)3.80290728
19DNA strand elongation involved in DNA replication (GO:0006271)3.79922401
20telomere maintenance via semi-conservative replication (GO:0032201)3.77854112
21rRNA methylation (GO:0031167)3.75719537
22viral transcription (GO:0019083)3.72922672
23maturation of SSU-rRNA (GO:0030490)3.71159684
24proteasome assembly (GO:0043248)3.69137733
25translational termination (GO:0006415)3.67660732
26ribosomal large subunit biogenesis (GO:0042273)3.66012037
27DNA strand elongation (GO:0022616)3.63666970
28deoxyribonucleoside diphosphate metabolic process (GO:0009186)3.62248934
29nucleobase-containing small molecule interconversion (GO:0015949)3.61478625
30IMP biosynthetic process (GO:0006188)3.57923123
31SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.57145901
32DNA replication checkpoint (GO:0000076)3.53533411
33ribosome biogenesis (GO:0042254)3.51372645
34mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.49203453
35mitochondrial respiratory chain complex I assembly (GO:0032981)3.49203453
36NADH dehydrogenase complex assembly (GO:0010257)3.49203453
37ribonucleoprotein complex biogenesis (GO:0022613)3.48727536
38translational elongation (GO:0006414)3.48578936
39cullin deneddylation (GO:0010388)3.47230482
40termination of RNA polymerase III transcription (GO:0006386)3.46729218
41transcription elongation from RNA polymerase III promoter (GO:0006385)3.46729218
42cotranslational protein targeting to membrane (GO:0006613)3.46335471
43protein targeting to ER (GO:0045047)3.45520662
44protein maturation by protein folding (GO:0022417)3.44591134
45regulation of cellular amine metabolic process (GO:0033238)3.42306162
46regulation of ubiquitin-protein transferase activity (GO:0051438)3.41273292
47spliceosomal snRNP assembly (GO:0000387)3.39071248
48protein deneddylation (GO:0000338)3.37099811
49negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.35817589
50oxidative phosphorylation (GO:0006119)3.31375070
51ribosomal small subunit biogenesis (GO:0042274)3.30482473
52protein localization to endoplasmic reticulum (GO:0070972)3.29198853
53rRNA modification (GO:0000154)3.28755255
54maturation of 5.8S rRNA (GO:0000460)3.28413978
55regulation of ligase activity (GO:0051340)3.28265106
56telomere maintenance via recombination (GO:0000722)3.28150114
57establishment of protein localization to endoplasmic reticulum (GO:0072599)3.26659293
58pteridine-containing compound biosynthetic process (GO:0042559)3.25606210
59viral mRNA export from host cell nucleus (GO:0046784)3.24359215
60DNA replication initiation (GO:0006270)3.23794657
61transcription from mitochondrial promoter (GO:0006390)3.23047013
62positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.22739532
63formation of translation preinitiation complex (GO:0001731)3.19324907
64antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.19117616
65ribosome assembly (GO:0042255)3.19083217
66pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.15781074
67regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.15597908
68purine-containing compound salvage (GO:0043101)3.13556311
69rRNA processing (GO:0006364)3.13354317
70translational initiation (GO:0006413)3.12704636
71antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.10894197
72mitotic metaphase plate congression (GO:0007080)3.10828508
73protein targeting to mitochondrion (GO:0006626)3.09919050
74anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.09542499
75regulation of cellular amino acid metabolic process (GO:0006521)3.08623787
76mitochondrial transport (GO:0006839)3.08074577
77cellular component biogenesis (GO:0044085)3.07348075
78inner mitochondrial membrane organization (GO:0007007)3.05770599
79DNA damage response, detection of DNA damage (GO:0042769)3.05279486
80CENP-A containing nucleosome assembly (GO:0034080)3.04544448
81establishment of viral latency (GO:0019043)3.04459122
82chromatin remodeling at centromere (GO:0031055)3.01998803
83regulation of translational fidelity (GO:0006450)3.01013496
84purine nucleoside triphosphate biosynthetic process (GO:0009145)3.00316954
85nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.00149531
86viral life cycle (GO:0019058)2.99216129
877-methylguanosine mRNA capping (GO:0006370)2.99208571
88negative regulation of protein ubiquitination (GO:0031397)2.98850105
89IMP metabolic process (GO:0046040)2.98794673
90ATP biosynthetic process (GO:0006754)2.98775201
91translation (GO:0006412)2.98660454
92rRNA metabolic process (GO:0016072)2.98514170
937-methylguanosine RNA capping (GO:0009452)2.98393012
94RNA capping (GO:0036260)2.98393012
95telomere maintenance via telomere lengthening (GO:0010833)2.97351480
96negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.97351465
97negative regulation of ligase activity (GO:0051352)2.97351465
98establishment of protein localization to mitochondrion (GO:0072655)2.96684779
99cellular protein complex disassembly (GO:0043624)2.96378744
100RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.95766669
101tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.95766669
102DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.95535753
103response to pheromone (GO:0019236)2.93841629
104L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.90733174
105signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.90649437
106intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.90649437
107signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.88259716
108signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.88259716
109signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.88259716
110cytochrome complex assembly (GO:0017004)2.85207127
111guanosine-containing compound biosynthetic process (GO:1901070)2.85140251
112positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.81131269
113regulation of mitochondrial translation (GO:0070129)2.80648249
114peptidyl-histidine modification (GO:0018202)2.80629328
115purine nucleotide salvage (GO:0032261)2.79422169
116signal transduction involved in DNA integrity checkpoint (GO:0072401)2.78729079
117signal transduction involved in DNA damage checkpoint (GO:0072422)2.78729079
118spliceosomal complex assembly (GO:0000245)2.78621150
119G1/S transition of mitotic cell cycle (GO:0000082)2.77807398
120cell cycle G1/S phase transition (GO:0044843)2.77807398
121positive regulation of ligase activity (GO:0051351)2.77693508
122mitotic recombination (GO:0006312)2.77447551
123pyrimidine nucleotide biosynthetic process (GO:0006221)2.76829580
124establishment of integrated proviral latency (GO:0075713)2.73607286
125signal transduction involved in cell cycle checkpoint (GO:0072395)2.73280553
126protein localization to mitochondrion (GO:0070585)2.72424293
127positive regulation of viral genome replication (GO:0045070)2.71674023
128transcription-coupled nucleotide-excision repair (GO:0006283)2.71314520
129regulation of double-strand break repair via homologous recombination (GO:0010569)2.70992750
130regulation of short-term neuronal synaptic plasticity (GO:0048172)2.70472954
131pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.69955861
132exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.69687820
133mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.69642767
134respiratory chain complex IV assembly (GO:0008535)2.68692428
135endosome to melanosome transport (GO:0035646)2.68648126

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.55151946
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.36657305
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.32419988
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.79796885
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.65993017
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.54481760
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.42604290
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.37471958
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.25722004
10MYC_18358816_ChIP-ChIP_MESCs_Mouse3.20792635
11* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.07330815
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.95236581
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.76661999
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.71918060
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.51333074
16XRN2_22483619_ChIP-Seq_HELA_Human2.47196120
17VDR_23849224_ChIP-Seq_CD4+_Human2.40539250
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.34577464
19THAP11_20581084_ChIP-Seq_MESCs_Mouse2.30104629
20DCP1A_22483619_ChIP-Seq_HELA_Human2.20014265
21E2F1_18555785_ChIP-Seq_MESCs_Mouse2.12965567
22YY1_21170310_ChIP-Seq_MESCs_Mouse2.12244453
23GABP_19822575_ChIP-Seq_HepG2_Human2.11546438
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.09336567
25* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.08627875
26TTF2_22483619_ChIP-Seq_HELA_Human2.06032621
27SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.99304647
28SRF_21415370_ChIP-Seq_HL-1_Mouse1.99126250
29FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.95571224
30* FOXP3_21729870_ChIP-Seq_TREG_Human1.94216899
31E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.90272668
32ELF1_17652178_ChIP-ChIP_JURKAT_Human1.88834996
33IRF8_21731497_ChIP-ChIP_J774_Mouse1.87782355
34NELFA_20434984_ChIP-Seq_ESCs_Mouse1.84633070
35PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.84177403
36CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.81981527
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.80051825
38SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.78824714
39ZNF263_19887448_ChIP-Seq_K562_Human1.75373298
40IRF8_22096565_ChIP-ChIP_GC-B_Human1.68028427
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.67938638
42SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.62126146
43FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.60434023
44ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.60189669
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57599735
46CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.56540942
47POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.56288794
48IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.55976241
49SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.55145569
50GATA1_22025678_ChIP-Seq_K562_Human1.52179863
51* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.50608298
52MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.48508862
53* E2F1_21310950_ChIP-Seq_MCF-7_Human1.47434843
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.47195990
55CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.44638727
56* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.44421240
57CIITA_25753668_ChIP-Seq_RAJI_Human1.44189697
58ELK1_19687146_ChIP-ChIP_HELA_Human1.42978271
59CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.42338481
60SRY_22984422_ChIP-ChIP_TESTIS_Rat1.40594568
61* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.39705244
62YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38945198
63* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.38312301
64DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.37905185
65CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.37510219
66ERG_20887958_ChIP-Seq_HPC-7_Mouse1.36152007
67PADI4_21655091_ChIP-ChIP_MCF-7_Human1.33004176
68HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.30499771
69TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.29839708
70CTCF_18555785_ChIP-Seq_MESCs_Mouse1.28966824
71MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.27596286
72SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.23330384
73NANOG_18555785_ChIP-Seq_MESCs_Mouse1.21278781
74ELK1_22589737_ChIP-Seq_MCF10A_Human1.21170835
75PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.17170468
76POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.17154294
77* SPI1_23547873_ChIP-Seq_NB4_Human1.16462055
78GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.15552709
79TFEB_21752829_ChIP-Seq_HELA_Human1.14501897
80FOXM1_23109430_ChIP-Seq_U2OS_Human1.14320024
81POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.13782916
82NOTCH1_21737748_ChIP-Seq_TLL_Human1.11567726
83IGF1R_20145208_ChIP-Seq_DFB_Human1.10477003
84CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.09086796
85E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09068198
86FOXP1_21924763_ChIP-Seq_HESCs_Human1.08929879
87EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.08315733
88ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.08022776
89KDM5A_27292631_Chip-Seq_BREAST_Human1.06037544
90EGR1_19374776_ChIP-ChIP_THP-1_Human1.05684465
91CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.04162305
92ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.03554735
93CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01580472
94* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00091904
95STAT3_1855785_ChIP-Seq_MESCs_Mouse0.98297174
96NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.97749678
97CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.97521097
98MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.97243191
99SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.96570543
100BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.94875764
101RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.94711130
102IKZF1_21737484_ChIP-ChIP_HCT116_Human0.93716244
103SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.93413304
104ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93382360
105CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.93116423
106CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.91389546
107HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.91240326
108TET1_21451524_ChIP-Seq_MESCs_Mouse0.91086739
109MYC_18940864_ChIP-ChIP_HL60_Human0.90381878
110KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.88452641
111KLF4_18555785_ChIP-Seq_MESCs_Mouse0.88427025
112ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.88052488
113MYC_22102868_ChIP-Seq_BL_Human0.87480279
114STAT4_19710469_ChIP-ChIP_TH1__Mouse0.86121342
115* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.85346599
116MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.85164790
117AR_21909140_ChIP-Seq_LNCAP_Human0.83972269
118SOX17_20123909_ChIP-Seq_XEN_Mouse0.81812871
119PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.81713313
120CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.81672881
121MYB_21317192_ChIP-Seq_ERMYB_Mouse0.81355574
122SOX2_18692474_ChIP-Seq_MEFs_Mouse0.78457771
123ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.77925625
124ELF5_23300383_ChIP-Seq_T47D_Human0.77604962

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis3.65062559
2MP0003123_paternal_imprinting3.51837349
3MP0003693_abnormal_embryo_hatching3.46294951
4MP0004859_abnormal_synaptic_plasticity2.87997603
5MP0001968_abnormal_touch/_nociception2.81999485
6MP0005423_abnormal_somatic_nervous2.77432596
7MP0002638_abnormal_pupillary_reflex2.70716928
8MP0009046_muscle_twitch2.58068991
9MP0003880_abnormal_central_pattern2.46981510
10MP0010094_abnormal_chromosome_stability2.44343029
11MP0003718_maternal_effect2.40797299
12MP0003111_abnormal_nucleus_morphology2.17670705
13MP0001835_abnormal_antigen_presentation2.15410905
14MP0002736_abnormal_nociception_after2.14121381
15MP0004957_abnormal_blastocyst_morpholog2.13659538
16MP0002735_abnormal_chemical_nociception2.12292429
17MP0002148_abnormal_hypersensitivity_rea2.08472312
18MP0003635_abnormal_synaptic_transmissio2.08286087
19MP0009785_altered_susceptibility_to2.04898223
20MP0005645_abnormal_hypothalamus_physiol2.04535613
21MP0008058_abnormal_DNA_repair2.01237986
22MP0003077_abnormal_cell_cycle2.00856439
23MP0002163_abnormal_gland_morphology2.00497177
24MP0002733_abnormal_thermal_nociception1.84781074
25MP0009379_abnormal_foot_pigmentation1.84155775
26MP0002064_seizures1.82220364
27MP0005451_abnormal_body_composition1.80951457
28MP0006276_abnormal_autonomic_nervous1.76797966
29MP0004858_abnormal_nervous_system1.73888482
30MP0001501_abnormal_sleep_pattern1.72201496
31MP0002734_abnormal_mechanical_nocicepti1.71393598
32MP0008007_abnormal_cellular_replicative1.70304927
33MP0003172_abnormal_lysosome_physiology1.70113063
34MP0001970_abnormal_pain_threshold1.69739177
35MP0009745_abnormal_behavioral_response1.68917439
36MP0003436_decreased_susceptibility_to1.68498399
37MP0008057_abnormal_DNA_replication1.65940625
38MP0001730_embryonic_growth_arrest1.65527844
39MP0003941_abnormal_skin_development1.58239517
40MP0009697_abnormal_copulation1.55000122
41MP0002272_abnormal_nervous_system1.53689335
42MP0008875_abnormal_xenobiotic_pharmacok1.50058900
43MP0009333_abnormal_splenocyte_physiolog1.46684711
44MP0001986_abnormal_taste_sensitivity1.45527646
45MP0001764_abnormal_homeostasis1.41747614
46MP0001188_hyperpigmentation1.41064559
47MP0005332_abnormal_amino_acid1.40841833
48MP0008877_abnormal_DNA_methylation1.40567553
49MP0008995_early_reproductive_senescence1.40283527
50MP0004142_abnormal_muscle_tone1.39192468
51MP0003186_abnormal_redox_activity1.39125322
52MP0005000_abnormal_immune_tolerance1.37403786
53MP0005408_hypopigmentation1.36722719
54MP0005671_abnormal_response_to1.35413673
55MP0006035_abnormal_mitochondrial_morpho1.33814261
56MP0010386_abnormal_urinary_bladder1.32743944
57MP0003122_maternal_imprinting1.32194967
58MP0001905_abnormal_dopamine_level1.31029414
59MP0001853_heart_inflammation1.27841243
60MP0004510_myositis1.27297001
61MP0002796_impaired_skin_barrier1.25675197
62MP0000358_abnormal_cell_content/1.24107310
63MP0002067_abnormal_sensory_capabilities1.23918562
64MP0001697_abnormal_embryo_size1.23406690
65MP0002909_abnormal_adrenal_gland1.22164615
66MP0002938_white_spotting1.20666562
67MP0005025_abnormal_response_to1.19764213
68MP0001661_extended_life_span1.19481072
69MP0008872_abnormal_physiological_respon1.18391101
70MP0005379_endocrine/exocrine_gland_phen1.17763917
71MP0002063_abnormal_learning/memory/cond1.16059612
72MP0008932_abnormal_embryonic_tissue1.15724193
73MP0005501_abnormal_skin_physiology1.15010242
74MP0002419_abnormal_innate_immunity1.14927324
75MP0002184_abnormal_innervation1.13686163
76MP0002210_abnormal_sex_determination1.12555102
77MP0002572_abnormal_emotion/affect_behav1.11908033
78MP0006292_abnormal_olfactory_placode1.11803040
79MP0009672_abnormal_birth_weight1.11437944
80MP0005174_abnormal_tail_pigmentation1.10362722
81MP0001881_abnormal_mammary_gland1.09708061
82MP0002396_abnormal_hematopoietic_system1.09600823
83MP0008569_lethality_at_weaning1.09531284
84MP0004811_abnormal_neuron_physiology1.09287630
85MP0002089_abnormal_postnatal_growth/wei1.07056910
86MP0001666_abnormal_nutrient_absorption1.05825056
87MP0005636_abnormal_mineral_homeostasis1.05461924
88MP0003315_abnormal_perineum_morphology1.03550319
89MP0005410_abnormal_fertilization1.03217152
90MP0002876_abnormal_thyroid_physiology1.03208041
91MP0004019_abnormal_vitamin_homeostasis1.02481589
92MP0003786_premature_aging1.02155682
93MP0004147_increased_porphyrin_level1.01521268
94MP0003724_increased_susceptibility_to1.01242013
95MP0003121_genomic_imprinting1.01235643
96MP0000579_abnormal_nail_morphology1.00531718
97MP0002080_prenatal_lethality1.00461587
98MP0001929_abnormal_gametogenesis1.00411140
99MP0008260_abnormal_autophagy1.00319774
100MP0003646_muscle_fatigue0.97364489
101MP0002723_abnormal_immune_serum0.93654222
102MP0006036_abnormal_mitochondrial_physio0.92097278
103MP0005380_embryogenesis_phenotype0.89798478
104MP0001672_abnormal_embryogenesis/_devel0.89798478
105MP0005083_abnormal_biliary_tract0.88631825
106MP0001145_abnormal_male_reproductive0.88323735
107MP0000313_abnormal_cell_death0.87231377
108MP0000490_abnormal_crypts_of0.87136197
109MP0003011_delayed_dark_adaptation0.86919470
110MP0003656_abnormal_erythrocyte_physiolo0.86057504
111MP0002006_tumorigenesis0.85250133
112MP0002398_abnormal_bone_marrow0.85228111
113MP0001529_abnormal_vocalization0.84744115
114MP0000653_abnormal_sex_gland0.84439184
115MP0008873_increased_physiological_sensi0.84306362
116MP0004924_abnormal_behavior0.84022844
117MP0005386_behavior/neurological_phenoty0.84022844
118MP0010307_abnormal_tumor_latency0.83927782
119MP0003075_altered_response_to0.82773236
120MP0002751_abnormal_autonomic_nervous0.82701587
121MP0001819_abnormal_immune_cell0.82411478
122MP0000350_abnormal_cell_proliferation0.82337320
123MP0005084_abnormal_gallbladder_morpholo0.81373611
124MP0002420_abnormal_adaptive_immunity0.80467149
125MP0002452_abnormal_antigen_presenting0.79863336
126MP0002693_abnormal_pancreas_physiology0.79495118
127MP0005397_hematopoietic_system_phenotyp0.78249416
128MP0001545_abnormal_hematopoietic_system0.78249416
129MP0000639_abnormal_adrenal_gland0.78034861
130MP0001502_abnormal_circadian_rhythm0.77523990
131MP0005395_other_phenotype0.76531185
132MP0000858_altered_metastatic_potential0.75466597
133MP0002160_abnormal_reproductive_system0.75032798
134MP0004808_abnormal_hematopoietic_stem0.74925827
135MP0005220_abnormal_exocrine_pancreas0.74531804
136MP0002085_abnormal_embryonic_tissue0.72570767
137MP0004270_analgesia0.71341651
138MP0002822_catalepsy0.70863240
139MP0001486_abnormal_startle_reflex0.70789795
140MP0003698_abnormal_male_reproductive0.69779844
141MP0000372_irregular_coat_pigmentation0.69568902
142MP0000716_abnormal_immune_system0.69361426
143MP0005646_abnormal_pituitary_gland0.69282656
144MP0002161_abnormal_fertility/fecundity0.67904231
145MP0003984_embryonic_growth_retardation0.67250529
146MP0000631_abnormal_neuroendocrine_gland0.66828413
147MP0005365_abnormal_bile_salt0.66759782
148MP0002088_abnormal_embryonic_growth/wei0.65494114
149MP0000678_abnormal_parathyroid_gland0.62651864
150MP0000538_abnormal_urinary_bladder0.61749439
151MP0001944_abnormal_pancreas_morphology0.61134095
152MP0005389_reproductive_system_phenotype0.60766066
153MP0010030_abnormal_orbit_morphology0.60055725
154MP0001485_abnormal_pinna_reflex0.59575017
155MP0002139_abnormal_hepatobiliary_system0.59405261
156MP0003937_abnormal_limbs/digits/tail_de0.57660946

Predicted human phenotypes

RankGene SetZ-score
1Acute encephalopathy (HP:0006846)4.89089121
2Abnormality of cells of the erythroid lineage (HP:0012130)4.78943021
3Abnormal number of erythroid precursors (HP:0012131)4.75536129
4Cerebral edema (HP:0002181)3.80990399
5Papilledema (HP:0001085)3.80421752
6Renal Fanconi syndrome (HP:0001994)3.74874507
7Aplastic anemia (HP:0001915)3.61665524
8Abnormality of glycolysis (HP:0004366)3.53817353
9Increased serum pyruvate (HP:0003542)3.52004560
10Poor head control (HP:0002421)3.51435870
11Reticulocytopenia (HP:0001896)3.43738130
12Oral leukoplakia (HP:0002745)3.22812468
13Increased intramyocellular lipid droplets (HP:0012240)3.21704204
14Severe visual impairment (HP:0001141)3.19711155
15Myokymia (HP:0002411)3.12963622
16Rough bone trabeculation (HP:0100670)3.05426601
17Mutism (HP:0002300)3.03194415
18Abnormality of aromatic amino acid family metabolism (HP:0004338)3.01088522
19Visual hallucinations (HP:0002367)2.99520420
20Testicular atrophy (HP:0000029)2.99000260
21Irregular epiphyses (HP:0010582)2.98085892
22Recurrent abscess formation (HP:0002722)2.96139207
23Respiratory failure (HP:0002878)2.95214396
24Abnormality of methionine metabolism (HP:0010901)2.84835389
25Recurrent bacterial skin infections (HP:0005406)2.84739000
26Premature graying of hair (HP:0002216)2.84457747
27Thrombocytosis (HP:0001894)2.82024884
28Type I transferrin isoform profile (HP:0003642)2.79994375
29Leukodystrophy (HP:0002415)2.79845516
30Sparse eyelashes (HP:0000653)2.79203334
31Hypothermia (HP:0002045)2.72723329
32Mitochondrial inheritance (HP:0001427)2.70383058
33Hepatocellular necrosis (HP:0001404)2.69690584
34Pallor (HP:0000980)2.68287761
35Degeneration of anterior horn cells (HP:0002398)2.66321792
36Abnormality of the anterior horn cell (HP:0006802)2.66321792
37Focal motor seizures (HP:0011153)2.64009822
38Cerebral hypomyelination (HP:0006808)2.64006032
39Respiratory difficulties (HP:0002880)2.62689244
40Birth length less than 3rd percentile (HP:0003561)2.62035661
41Decreased activity of mitochondrial respiratory chain (HP:0008972)2.61770916
42Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.61770916
43Microretrognathia (HP:0000308)2.61571178
44Increased muscle lipid content (HP:0009058)2.58267084
45Macrocytic anemia (HP:0001972)2.58210589
46Acute necrotizing encephalopathy (HP:0006965)2.54715744
47Abnormal trabecular bone morphology (HP:0100671)2.53185690
48Lethargy (HP:0001254)2.51898397
49Abnormal mitochondria in muscle tissue (HP:0008316)2.51282646
50Cleft eyelid (HP:0000625)2.47527857
51Gout (HP:0001997)2.47238919
52Methylmalonic aciduria (HP:0012120)2.43694834
53Increased hepatocellular lipid droplets (HP:0006565)2.43514438
54Mediastinal lymphadenopathy (HP:0100721)2.40930959
55Methylmalonic acidemia (HP:0002912)2.39692106
56Unsteady gait (HP:0002317)2.39660652
57Exertional dyspnea (HP:0002875)2.36318384
58Reduced antithrombin III activity (HP:0001976)2.32761989
59Increased CSF lactate (HP:0002490)2.31999311
60Hepatic necrosis (HP:0002605)2.31130021
61Increased serum lactate (HP:0002151)2.29141556
62Optic disc pallor (HP:0000543)2.26459017
63Basal ganglia calcification (HP:0002135)2.26405266
64Hypokinesia (HP:0002375)2.24431978
65Eczematoid dermatitis (HP:0000976)2.21750062
66Progressive macrocephaly (HP:0004481)2.20734603
67Obstructive lung disease (HP:0006536)2.20087262
68Chronic obstructive pulmonary disease (HP:0006510)2.20087262
69Tetraplegia (HP:0002445)2.20014914
70Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.19553095
71Abnormal protein N-linked glycosylation (HP:0012347)2.19553095
72Abnormal protein glycosylation (HP:0012346)2.19553095
73Abnormal glycosylation (HP:0012345)2.19553095
74CNS demyelination (HP:0007305)2.18111798
75Neuroendocrine neoplasm (HP:0100634)2.17977655
76Abnormality of renal resorption (HP:0011038)2.17278868
77Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.15982543
78Progressive muscle weakness (HP:0003323)2.15779604
79Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.14347438
80Carpal bone hypoplasia (HP:0001498)2.12830551
81Elevated erythrocyte sedimentation rate (HP:0003565)2.07965593
82Aplasia/hypoplasia of the uterus (HP:0008684)2.07286845
83Absence seizures (HP:0002121)2.06425846
84Abnormality of urine glucose concentration (HP:0011016)2.05235898
85Glycosuria (HP:0003076)2.05235898
86Hypoplasia of the pons (HP:0012110)2.03441044
87Multiple enchondromatosis (HP:0005701)2.01912935
88Generalized aminoaciduria (HP:0002909)1.98953043
89Abnormality of serum amino acid levels (HP:0003112)1.98912809
90Patent foramen ovale (HP:0001655)1.98587493
91Neoplasm of the peripheral nervous system (HP:0100007)1.97943264
9211 pairs of ribs (HP:0000878)1.97112588
93Hyperphosphaturia (HP:0003109)1.96917281
94Lipid accumulation in hepatocytes (HP:0006561)1.96907333
95X-linked dominant inheritance (HP:0001423)1.94244510
96Exercise intolerance (HP:0003546)1.93146460
97Abnormal gallbladder physiology (HP:0012438)1.92931473
98Cholecystitis (HP:0001082)1.92931473
99Limb dystonia (HP:0002451)1.92665238
100Opisthotonus (HP:0002179)1.92393859
101Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.92002427
102Abnormality of sulfur amino acid metabolism (HP:0004339)1.91539893
103Abnormality of aspartate family amino acid metabolism (HP:0010899)1.91274126
1043-Methylglutaconic aciduria (HP:0003535)1.91265227
105Pheochromocytoma (HP:0002666)1.90955589
106Increased IgM level (HP:0003496)1.90218356
107Megaloblastic anemia (HP:0001889)1.89662321
108Abnormality of the preputium (HP:0100587)1.88516291
109Amniotic constriction ring (HP:0009775)1.87899306
110Abnormality of placental membranes (HP:0011409)1.87899306
111Abnormality of alanine metabolism (HP:0010916)1.87533062
112Hyperalaninemia (HP:0003348)1.87533062
113Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.87533062
114Progressive cerebellar ataxia (HP:0002073)1.87003386
115Vertebral compression fractures (HP:0002953)1.86688698
116Cellular immunodeficiency (HP:0005374)1.85497001
117Microvesicular hepatic steatosis (HP:0001414)1.84502815
118CNS hypomyelination (HP:0003429)1.84305370
119Emotional lability (HP:0000712)1.83687302
120Flat capital femoral epiphysis (HP:0003370)1.83336243
121Tracheoesophageal fistula (HP:0002575)1.79995231
122Spinal cord compression (HP:0002176)1.79608839
123Hypermelanotic macule (HP:0001034)1.79303822
124Ragged-red muscle fibers (HP:0003200)1.79295317
125Meckel diverticulum (HP:0002245)1.78894063
126Myositis (HP:0100614)1.78824310
127Absent epiphyses (HP:0010577)1.78620553
128Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.78620553
129Focal seizures (HP:0007359)1.77318946
130Atrophy/Degeneration involving motor neurons (HP:0007373)1.77156649
131Pancytopenia (HP:0001876)1.76846775
132Horizontal nystagmus (HP:0000666)1.76736820
133Aplasia/Hypoplasia of the sacrum (HP:0008517)1.75609481
134Muscular hypotonia of the trunk (HP:0008936)1.74785684
135Glossoptosis (HP:0000162)1.74233327
136Diminished movement (HP:0002374)1.72918891
137Patellar aplasia (HP:0006443)1.72879865
138Hypoplasia of the capital femoral epiphysis (HP:0003090)1.71677892
139Abnormality of the labia minora (HP:0012880)1.71179227
140Lactic acidosis (HP:0003128)1.70730682
141Poor suck (HP:0002033)1.70670390
142Pili torti (HP:0003777)1.69426825
143Abnormality of macrophages (HP:0004311)1.69315073
144Gliosis (HP:0002171)1.68853471
145Dicarboxylic aciduria (HP:0003215)1.68784647
146Abnormality of dicarboxylic acid metabolism (HP:0010995)1.68784647
147Dialeptic seizures (HP:0011146)1.68630759
148Abnormality of magnesium homeostasis (HP:0004921)1.67142839
149Delusions (HP:0000746)1.65455519
150Choreoathetosis (HP:0001266)1.65128851

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.77178640
2STK163.80223668
3EIF2AK13.36850509
4BUB13.01143097
5MST43.00195493
6WEE12.83445941
7MAP3K122.73178771
8PIM22.72212358
9EIF2AK32.68987565
10NTRK32.56640048
11NME22.51289749
12ARAF2.41457402
13CAMKK22.24101581
14SRPK12.22311996
15SCYL22.17366929
16ZAK2.09639394
17TTK2.04928703
18MAP3K112.04085908
19BRSK22.03692293
20CDC72.03056426
21BRSK12.02758668
22PDK22.01429312
23VRK11.81680641
24PBK1.74658477
25TLK11.67698992
26BLK1.65881783
27BCKDK1.59473260
28MINK11.59270217
29MAP3K131.53891558
30MAP2K71.51317797
31TNIK1.45098598
32NME11.41976416
33RIPK41.34877303
34TRIM281.32800854
35IRAK41.31858659
36ACVR1B1.31539604
37CAMKK11.30644304
38TSSK61.28259370
39EPHA21.27401043
40TAF11.17752970
41MAPKAPK51.17463432
42BRAF1.14592619
43PLK41.12691496
44NEK11.10671281
45PINK11.09518919
46CDK81.09427585
47PLK11.07316301
48NUAK11.06390744
49ABL21.06367705
50PLK31.04370278
51CSNK1G31.03886945
52CDK191.03159337
53MST1R1.03138584
54PRKCI1.02247529
55CHEK20.99569697
56TESK20.98586400
57NEK90.98126883
58KSR20.96890878
59LIMK10.96083377
60CCNB10.95554700
61TESK10.95001198
62RAF10.94800715
63MATK0.94475506
64PHKG20.94154338
65PHKG10.94154338
66DAPK10.93586140
67MAP3K90.92303969
68TAOK20.92147889
69EIF2AK20.91620210
70PAK40.88551238
71TEC0.87090130
72SMG10.86474914
73CSNK1G10.83560656
74ATR0.81819810
75OXSR10.81266333
76FES0.80125505
77MAP3K140.79785656
78STK390.78722860
79CSNK1G20.77458915
80RPS6KA40.77253725
81GRK10.76344884
82IRAK20.75489380
83MAP3K10.74827890
84ALK0.74709341
85KIT0.74270645
86NTRK10.73879745
87PASK0.72800136
88ILK0.72611448
89MUSK0.68848728
90CAMK2G0.63232514
91DAPK30.62861739
92AURKA0.62331223
93WNK40.61460825
94ERBB30.60494785
95PRPF4B0.59963844
96RPS6KA50.59450967
97AURKB0.57401196
98LATS20.57187354
99GRK50.57091614
100MARK10.55471086
101MAP3K40.54733115
102PLK20.53464947
103PAK10.53066392
104TBK10.52871055
105IKBKB0.52316597
106CHEK10.52087075
107PRKG20.49840975
108DYRK20.49654877
109MAP2K30.49293509
110PAK60.49009288
111CDK70.48576647
112TAOK10.47717375
113CSNK1E0.47295862
114LYN0.46539121
115ZAP700.45538064
116CSNK1A1L0.45497127
117KDR0.45411018
118JAK30.44955727
119MAP3K50.44860169
120CSNK2A10.44852502
121MAPKAPK30.44762490
122BTK0.44096370
123CAMK10.43346732
124SYK0.43137320
125IRAK30.42691664
126AKT20.41996487
127UHMK10.41782449
128CDK140.40818078
129PRKCG0.40654678
130INSRR0.40431620
131CSNK2A20.40144005
132MAP3K80.39375269
133ADRBK20.39107947
134WNK30.39033817
135CDK11A0.38519234
136CAMK2B0.38488470
137CDK180.37469237
138CDK150.37167782
139STK40.36865184
140CAMK2D0.36753856
141RPS6KB20.35291951
142NEK20.34437664
143MAP2K60.33747205
144MAP2K40.33632914
145CSNK1A10.32491268
146RPS6KB10.32026125
147ATM0.30998882
148CDK10.28774171

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.09924271
2DNA replication_Homo sapiens_hsa030303.98483100
3Ribosome_Homo sapiens_hsa030103.98427609
4RNA polymerase_Homo sapiens_hsa030203.46950627
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.91314064
6Pyrimidine metabolism_Homo sapiens_hsa002402.67998935
7Mismatch repair_Homo sapiens_hsa034302.62773658
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.52928875
9Base excision repair_Homo sapiens_hsa034102.49856070
10Spliceosome_Homo sapiens_hsa030402.35661544
11Type I diabetes mellitus_Homo sapiens_hsa049402.25436362
12Homologous recombination_Homo sapiens_hsa034402.16307750
13Synaptic vesicle cycle_Homo sapiens_hsa047212.11627047
14Sulfur relay system_Homo sapiens_hsa041222.11163560
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.97331641
16Nucleotide excision repair_Homo sapiens_hsa034201.88715207
17RNA transport_Homo sapiens_hsa030131.88168967
18Vitamin B6 metabolism_Homo sapiens_hsa007501.83891511
19Protein export_Homo sapiens_hsa030601.80269055
20Nicotine addiction_Homo sapiens_hsa050331.74113982
21Parkinsons disease_Homo sapiens_hsa050121.70917772
22Oxidative phosphorylation_Homo sapiens_hsa001901.65629105
23Fatty acid elongation_Homo sapiens_hsa000621.55094604
24Sulfur metabolism_Homo sapiens_hsa009201.53889163
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.53274394
26Purine metabolism_Homo sapiens_hsa002301.49087340
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.44611483
28Pyruvate metabolism_Homo sapiens_hsa006201.43803083
29Graft-versus-host disease_Homo sapiens_hsa053321.40515168
30Huntingtons disease_Homo sapiens_hsa050161.37577938
31RNA degradation_Homo sapiens_hsa030181.32678661
32Glutathione metabolism_Homo sapiens_hsa004801.22261746
33One carbon pool by folate_Homo sapiens_hsa006701.20487378
34Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.20438437
35Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.17565586
36GABAergic synapse_Homo sapiens_hsa047271.15257917
37Cell cycle_Homo sapiens_hsa041101.13503463
38Allograft rejection_Homo sapiens_hsa053301.10941206
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.06604575
40SNARE interactions in vesicular transport_Homo sapiens_hsa041301.06227013
41Carbon metabolism_Homo sapiens_hsa012001.02081938
42Legionellosis_Homo sapiens_hsa051341.01240715
43Selenocompound metabolism_Homo sapiens_hsa004500.99830973
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.99024095
45Propanoate metabolism_Homo sapiens_hsa006400.97355660
46Cardiac muscle contraction_Homo sapiens_hsa042600.96298490
47Galactose metabolism_Homo sapiens_hsa000520.95893916
48Fanconi anemia pathway_Homo sapiens_hsa034600.93409437
49Epstein-Barr virus infection_Homo sapiens_hsa051690.93222360
50Vibrio cholerae infection_Homo sapiens_hsa051100.92983153
51Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.90851341
52Basal transcription factors_Homo sapiens_hsa030220.90459836
53Alzheimers disease_Homo sapiens_hsa050100.89681828
54RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.89471423
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.88622573
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.88168936
57Metabolic pathways_Homo sapiens_hsa011000.87508770
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85605063
59Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.84893019
60Steroid biosynthesis_Homo sapiens_hsa001000.83254336
61Collecting duct acid secretion_Homo sapiens_hsa049660.83040580
62Herpes simplex infection_Homo sapiens_hsa051680.82821258
63Toll-like receptor signaling pathway_Homo sapiens_hsa046200.81862255
64Oocyte meiosis_Homo sapiens_hsa041140.80063228
65Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.79659273
66Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.79397867
67Rheumatoid arthritis_Homo sapiens_hsa053230.77476013
68N-Glycan biosynthesis_Homo sapiens_hsa005100.76949063
69Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.76550510
70Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73465701
71Influenza A_Homo sapiens_hsa051640.72983785
72Leishmaniasis_Homo sapiens_hsa051400.72402092
73Arginine and proline metabolism_Homo sapiens_hsa003300.71988393
74Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69359977
75Pentose phosphate pathway_Homo sapiens_hsa000300.69087820
76Morphine addiction_Homo sapiens_hsa050320.68651822
77Olfactory transduction_Homo sapiens_hsa047400.67666739
78Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.66945622
79Circadian entrainment_Homo sapiens_hsa047130.66674728
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.64171168
81Antigen processing and presentation_Homo sapiens_hsa046120.62408521
82Folate biosynthesis_Homo sapiens_hsa007900.62312267
83p53 signaling pathway_Homo sapiens_hsa041150.61801561
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.61625111
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60661541
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60137485
87Non-homologous end-joining_Homo sapiens_hsa034500.60109378
88NOD-like receptor signaling pathway_Homo sapiens_hsa046210.59725313
89beta-Alanine metabolism_Homo sapiens_hsa004100.59239335
90Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57329848
91Peroxisome_Homo sapiens_hsa041460.57020441
92Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.54011084
93Tuberculosis_Homo sapiens_hsa051520.53790792
94mRNA surveillance pathway_Homo sapiens_hsa030150.53774236
95Insulin secretion_Homo sapiens_hsa049110.52367425
96Phagosome_Homo sapiens_hsa041450.52251212
97Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.50242194
98Pertussis_Homo sapiens_hsa051330.49647560
99Long-term potentiation_Homo sapiens_hsa047200.49515244
100Fructose and mannose metabolism_Homo sapiens_hsa000510.49060968
101Cysteine and methionine metabolism_Homo sapiens_hsa002700.47814285
102Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47796557
103Dopaminergic synapse_Homo sapiens_hsa047280.47542713
104Glutamatergic synapse_Homo sapiens_hsa047240.47513234
105Primary bile acid biosynthesis_Homo sapiens_hsa001200.47432183
106Vitamin digestion and absorption_Homo sapiens_hsa049770.46185153
107Intestinal immune network for IgA production_Homo sapiens_hsa046720.46030966
108Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44704904
109Biosynthesis of amino acids_Homo sapiens_hsa012300.44329039
110Asthma_Homo sapiens_hsa053100.44228903
111Shigellosis_Homo sapiens_hsa051310.44149009
112Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43699626
113Alcoholism_Homo sapiens_hsa050340.43178348
114Phenylalanine metabolism_Homo sapiens_hsa003600.42942637
115Tyrosine metabolism_Homo sapiens_hsa003500.42282198
116Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41838232
117Apoptosis_Homo sapiens_hsa042100.41746539
118Amphetamine addiction_Homo sapiens_hsa050310.41261568
119Salmonella infection_Homo sapiens_hsa051320.40910200
120Measles_Homo sapiens_hsa051620.40760785
121Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.40514323
122Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.39940645
123Thyroid cancer_Homo sapiens_hsa052160.39829702
124Fatty acid metabolism_Homo sapiens_hsa012120.38153912
125Cocaine addiction_Homo sapiens_hsa050300.37456378
126Cholinergic synapse_Homo sapiens_hsa047250.37443264
127Lysosome_Homo sapiens_hsa041420.35164741
128Arginine biosynthesis_Homo sapiens_hsa002200.34437478
129Regulation of autophagy_Homo sapiens_hsa041400.33702730
130Serotonergic synapse_Homo sapiens_hsa047260.32620704
131Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.31797397
132Taste transduction_Homo sapiens_hsa047420.31575680
133Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.31447642
134Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.31169032
135Maturity onset diabetes of the young_Homo sapiens_hsa049500.30054618
136Neurotrophin signaling pathway_Homo sapiens_hsa047220.29921722
137HIF-1 signaling pathway_Homo sapiens_hsa040660.29844889
138Long-term depression_Homo sapiens_hsa047300.28707594
139Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.28665738
140Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.28462609
141Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.26948252
142Butanoate metabolism_Homo sapiens_hsa006500.25161703
143Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.21443182
144Fatty acid degradation_Homo sapiens_hsa000710.20923903
145Tryptophan metabolism_Homo sapiens_hsa003800.17745314
146Chemical carcinogenesis_Homo sapiens_hsa052040.10812597
147Mineral absorption_Homo sapiens_hsa049780.10803003
148Fat digestion and absorption_Homo sapiens_hsa049750.07673187
149Sphingolipid metabolism_Homo sapiens_hsa006000.07582014

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