ECEL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the M13 family of endopeptidases. Members of this family are zinc-containing type II integral-membrane proteins that are important regulators of neuropeptide and peptide hormone activity. Mutations in this gene are associated with autosomal recessive distal arthrogryposis, type 5D. This gene has multiple pseudogenes on chromosome 2. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1layer formation in cerebral cortex (GO:0021819)6.28112280
2skeletal muscle organ development (GO:0060538)5.52029983
3midgut development (GO:0007494)5.27300621
4head development (GO:0060322)5.25723322
5positive regulation of synaptic transmission, GABAergic (GO:0032230)5.24661335
6negative regulation of amyloid precursor protein catabolic process (GO:1902992)4.94801931
7positive regulation of odontogenesis (GO:0042482)4.91423634
8proline biosynthetic process (GO:0006561)4.88001882
9synaptic vesicle maturation (GO:0016188)4.62363921
10regulation of respiratory gaseous exchange by neurological system process (GO:0002087)4.61817595
11neuromuscular process controlling posture (GO:0050884)4.60966063
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.57332819
13establishment of monopolar cell polarity (GO:0061162)4.52613719
14establishment or maintenance of monopolar cell polarity (GO:0061339)4.52613719
15synaptic vesicle exocytosis (GO:0016079)4.48161173
16locomotory exploration behavior (GO:0035641)4.46724074
17regulation of short-term neuronal synaptic plasticity (GO:0048172)4.46472411
18diaphragm development (GO:0060539)4.45549244
19neuron projection extension involved in neuron projection guidance (GO:1902284)4.39601411
20axon extension involved in axon guidance (GO:0048846)4.39601411
21neurotransmitter secretion (GO:0007269)4.32136972
22metanephric mesenchyme development (GO:0072075)4.28110477
23establishment of apical/basal cell polarity (GO:0035089)4.25390175
24positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.11502125
25cell migration in hindbrain (GO:0021535)4.10533984
26dendritic spine morphogenesis (GO:0060997)4.10156832
27negative regulation of protein oligomerization (GO:0032460)4.04802117
28homocysteine metabolic process (GO:0050667)4.03564678
29polarized epithelial cell differentiation (GO:0030859)3.96066314
30neuromuscular process controlling balance (GO:0050885)3.92249390
31embryonic body morphogenesis (GO:0010172)3.92126647
32protein localization to synapse (GO:0035418)3.90730930
33body morphogenesis (GO:0010171)3.89569225
34positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.87719061
35regulation of respiratory system process (GO:0044065)3.86677455
36paraxial mesoderm development (GO:0048339)3.86651234
37regulation of protein homooligomerization (GO:0032462)3.85652634
38regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.84295284
39glial cell proliferation (GO:0014009)3.75694759
40negative regulation of catenin import into nucleus (GO:0035414)3.75671165
41regulation of synaptic vesicle exocytosis (GO:2000300)3.74793534
42regulation of cAMP-dependent protein kinase activity (GO:2000479)3.74760939
43vocalization behavior (GO:0071625)3.74195520
44cAMP catabolic process (GO:0006198)3.70862231
45neuron cell-cell adhesion (GO:0007158)3.70569637
46planar cell polarity pathway involved in neural tube closure (GO:0090179)3.68800207
47* respiratory system process (GO:0003016)3.62960944
48synaptic vesicle endocytosis (GO:0048488)3.61210060
49regulation of glutamate receptor signaling pathway (GO:1900449)3.60791747
50branching involved in salivary gland morphogenesis (GO:0060445)3.59375551
51positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.58146795
52glutamate secretion (GO:0014047)3.57107568
53kidney mesenchyme development (GO:0072074)3.56916739
54regulation of neuronal synaptic plasticity (GO:0048168)3.52138474
55cornea development in camera-type eye (GO:0061303)3.51653544
56proline metabolic process (GO:0006560)3.49899036
57positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.46690424
58citrulline metabolic process (GO:0000052)3.46588480
59response to auditory stimulus (GO:0010996)3.44752824
60glial cell migration (GO:0008347)3.44270102
61regulation of amyloid precursor protein catabolic process (GO:1902991)3.40853649
62regulation of beta-amyloid formation (GO:1902003)3.39832110
63signal complex assembly (GO:0007172)3.39703073
64regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.37293092
65proximal/distal pattern formation (GO:0009954)3.33260693
66pyrimidine nucleobase catabolic process (GO:0006208)3.32916131
67activation of protein kinase A activity (GO:0034199)3.30663034
68positive regulation of potassium ion transmembrane transport (GO:1901381)3.29784667
69neurotransmitter transport (GO:0006836)3.29350158
70neuromuscular process (GO:0050905)3.28501529
71regulation of respiratory gaseous exchange (GO:0043576)3.27266838
72gamma-aminobutyric acid transport (GO:0015812)3.26711574
73cranial nerve morphogenesis (GO:0021602)3.25736037
74exploration behavior (GO:0035640)3.24845220
75ganglion development (GO:0061548)3.22786643
76regulation of synaptic vesicle transport (GO:1902803)3.22333804
77urea cycle (GO:0000050)3.20454533
78dendrite morphogenesis (GO:0048813)3.20412906
79embryonic forelimb morphogenesis (GO:0035115)3.19314807
80proline transport (GO:0015824)3.17878172
81L-alpha-amino acid transmembrane transport (GO:1902475)3.16731776
82axon extension (GO:0048675)3.13843324
83establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)3.13733911
84regulation of neurotransmitter levels (GO:0001505)3.09484099
85neurofilament cytoskeleton organization (GO:0060052)3.08315325
86aggressive behavior (GO:0002118)3.08281350
87G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.08209437
88cyclic nucleotide catabolic process (GO:0009214)3.07915132
89central nervous system projection neuron axonogenesis (GO:0021952)3.06200144
90transmission of nerve impulse (GO:0019226)3.06137070
91sodium ion export (GO:0071436)3.06041327
92regulation of long-term neuronal synaptic plasticity (GO:0048169)3.05938929
93dopamine receptor signaling pathway (GO:0007212)3.03333706
94embryonic skeletal joint morphogenesis (GO:0060272)3.02098581
95neuromuscular synaptic transmission (GO:0007274)3.01513261
96notochord development (GO:0030903)3.00672295
97positive regulation of dendritic spine morphogenesis (GO:0061003)2.99407460
98cellular potassium ion homeostasis (GO:0030007)2.98809818
99mating behavior (GO:0007617)2.98388857
100middle ear morphogenesis (GO:0042474)2.98041740
101forelimb morphogenesis (GO:0035136)2.95945455
102regulation of synapse structural plasticity (GO:0051823)2.94223776
103axonal fasciculation (GO:0007413)2.93852062
104transcription from mitochondrial promoter (GO:0006390)2.93735903
105regulation of glutamate secretion (GO:0014048)2.92226081
106cerebral cortex neuron differentiation (GO:0021895)2.91536653
107cell communication by electrical coupling (GO:0010644)2.91434531
108hindlimb morphogenesis (GO:0035137)2.90770959
109positive regulation of dendritic spine development (GO:0060999)2.89998599
110long-term synaptic potentiation (GO:0060291)2.89991398
111citrulline biosynthetic process (GO:0019240)2.88861042
112embryonic skeletal system morphogenesis (GO:0048704)2.87975091
113negative regulation of astrocyte differentiation (GO:0048712)2.87862791
114Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.87676644
115ionotropic glutamate receptor signaling pathway (GO:0035235)2.86435893
116postsynaptic membrane organization (GO:0001941)2.86237409
117segment specification (GO:0007379)2.85625212
118adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.85596314
119negative regulation of axon guidance (GO:1902668)2.84991128
120glycine transport (GO:0015816)2.84232631
121lateral sprouting from an epithelium (GO:0060601)2.84134409
122urea metabolic process (GO:0019627)2.84038055
123embryonic cranial skeleton morphogenesis (GO:0048701)2.82532063
124embryonic hindlimb morphogenesis (GO:0035116)2.82454824
125neurotransmitter-gated ion channel clustering (GO:0072578)2.82388430
126collagen fibril organization (GO:0030199)2.82085982
127neuron recognition (GO:0008038)2.82071181
128positive regulation of vascular permeability (GO:0043117)2.81676337
129synaptic vesicle docking involved in exocytosis (GO:0016081)2.81161879
130axon cargo transport (GO:0008088)2.81009943
131negative regulation of microtubule polymerization (GO:0031115)2.80450000
132regulation of synaptic transmission, glutamatergic (GO:0051966)2.79968648
133regulation of synaptic transmission, GABAergic (GO:0032228)2.78162781
134regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.77881368
135generation of neurons (GO:0048699)2.74877582
136regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.74708411
137presynaptic membrane assembly (GO:0097105)2.74307615
138negative regulation of JAK-STAT cascade (GO:0046426)2.73348018
139presynaptic membrane organization (GO:0097090)2.73094102
140retinal ganglion cell axon guidance (GO:0031290)2.72577816
141establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.72429058
142mitochondrion transport along microtubule (GO:0047497)2.72429058
143nucleobase catabolic process (GO:0046113)2.72319097
144regulation of establishment of planar polarity (GO:0090175)2.72025511
145cellular response to ATP (GO:0071318)2.71755308
146positive regulation of synaptic transmission (GO:0050806)2.70544652
147auditory behavior (GO:0031223)2.70152150
148neuronal action potential propagation (GO:0019227)2.69389447
149convergent extension (GO:0060026)2.69293499
150regulation of dendritic spine morphogenesis (GO:0061001)2.68769058
151positive regulation of protein homooligomerization (GO:0032464)2.67643498
152positive regulation of gastrulation (GO:2000543)2.67353830
153negative regulation of amino acid transport (GO:0051956)2.67138940
154neuron projection extension (GO:1990138)2.66035893
155neuronal ion channel clustering (GO:0045161)2.64174548
156long-term memory (GO:0007616)2.63872677
157regulation of neurotransmitter secretion (GO:0046928)2.63871042
158cellular response to glucagon stimulus (GO:0071377)2.63156107
159outer ear morphogenesis (GO:0042473)2.61453663
160cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.61405881
161dorsal/ventral axis specification (GO:0009950)2.58451285
162negative regulation of gluconeogenesis (GO:0045721)2.57217036
163negative regulation of axon extension involved in axon guidance (GO:0048843)2.54370249
164glomerular filtration (GO:0003094)2.54350259
165digestive tract development (GO:0048565)2.54233861
166organ induction (GO:0001759)2.50069004
167establishment of mitochondrion localization (GO:0051654)2.50037878
168non-canonical Wnt signaling pathway (GO:0035567)2.49537111
169skeletal system morphogenesis (GO:0048705)2.49480785
170neurogenesis (GO:0022008)2.49161456
171embryonic appendage morphogenesis (GO:0035113)2.48942112
172embryonic limb morphogenesis (GO:0030326)2.48942112
173peripheral nervous system neuron development (GO:0048935)2.46543547
174negative regulation of complement activation (GO:0045916)2.45492339
175negative chemotaxis (GO:0050919)2.45047465
176lung-associated mesenchyme development (GO:0060484)2.43622132
177morphogenesis of an epithelial sheet (GO:0002011)2.42543163
178palate development (GO:0060021)2.41975173
179hepatocyte differentiation (GO:0070365)2.41598751
180enteric nervous system development (GO:0048484)2.39838808
181cell-cell junction maintenance (GO:0045217)2.39787666
182muscle cell proliferation (GO:0033002)2.39550386
183cell surface receptor signaling pathway involved in heart development (GO:0061311)2.37675682
184nitrogen cycle metabolic process (GO:0071941)2.36790604
185positive regulation of smoothened signaling pathway (GO:0045880)2.36645519
186peptidyl-arginine omega-N-methylation (GO:0035247)2.36063097

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.50475866
2* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.07904369
3ERG_21242973_ChIP-ChIP_JURKAT_Human2.96903625
4* REST_21632747_ChIP-Seq_MESCs_Mouse2.77057418
5* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.65766781
6* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.61108717
7IKZF1_21737484_ChIP-ChIP_HCT116_Human2.61050345
8* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.60215517
9* REST_18959480_ChIP-ChIP_MESCs_Mouse2.53808649
10* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.47644359
11RARB_27405468_Chip-Seq_BRAIN_Mouse2.44776912
12* EZH2_27304074_Chip-Seq_ESCs_Mouse2.40817963
13NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.39573132
14* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.35893354
15MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.31734809
16* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.31157281
17* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.30505846
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.27068350
19* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.25479758
20* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.24890125
21* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.24721288
22* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.24721288
23* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.13165115
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.08949465
25* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.02143894
26KLF4_19030024_ChIP-ChIP_MESCs_Mouse2.01615525
27* EZH2_27294783_Chip-Seq_ESCs_Mouse1.99926608
28CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.97324933
29EED_16625203_ChIP-ChIP_MESCs_Mouse1.97249835
30DROSHA_22980978_ChIP-Seq_HELA_Human1.97189821
31* RNF2_27304074_Chip-Seq_ESCs_Mouse1.94902472
32ESR1_15608294_ChIP-ChIP_MCF-7_Human1.92596900
33SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.92138797
34RBPJ_22232070_ChIP-Seq_NCS_Mouse1.80212888
35RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.79662012
36DNAJC2_21179169_ChIP-ChIP_NT2_Human1.77415345
37* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.75683166
38* TP53_20018659_ChIP-ChIP_R1E_Mouse1.74979734
39SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.70922662
40* RING1B_27294783_Chip-Seq_ESCs_Mouse1.68369982
41NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.65463963
42GATA1_26923725_Chip-Seq_HPCs_Mouse1.63215261
43LXR_22292898_ChIP-Seq_THP-1_Human1.61186733
44ZNF274_21170338_ChIP-Seq_K562_Hela1.60698937
45AR_21572438_ChIP-Seq_LNCaP_Human1.60663660
46* RING1B_27294783_Chip-Seq_NPCs_Mouse1.56375043
47* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.54905641
48KDM2B_26808549_Chip-Seq_K562_Human1.54102788
49RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.52915171
50TP63_19390658_ChIP-ChIP_HaCaT_Human1.52796422
51MYC_18555785_ChIP-Seq_MESCs_Mouse1.47696922
52ISL1_27105846_Chip-Seq_CPCs_Mouse1.45867070
53* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.45009198
54SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.44024229
55CTCF_27219007_Chip-Seq_Bcells_Human1.41667559
56OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.41463644
57XRN2_22483619_ChIP-Seq_HELA_Human1.36160380
58POU5F1_16153702_ChIP-ChIP_HESCs_Human1.33636823
59BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.33131611
60CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.32291708
61PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.28948185
62STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.28099620
63SOX2_16153702_ChIP-ChIP_HESCs_Human1.24591706
64TET1_21490601_ChIP-Seq_MESCs_Mouse1.24463420
65KDM2B_26808549_Chip-Seq_SUP-B15_Human1.23043593
66WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.22565261
67HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.20209217
68POU5F1_16518401_ChIP-PET_MESCs_Mouse1.19208854
69CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.18174126
70TRIM28_21343339_ChIP-Seq_HEK293_Human1.17771659
71WT1_19549856_ChIP-ChIP_CCG9911_Human1.15128413
72PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.14770052
73SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.13526943
74* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12714197
75ZNF263_19887448_ChIP-Seq_K562_Human1.11466506
76TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.11319123
77CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.09489290
78HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.09175526
79KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.09114195
80KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.09114195
81KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.09114195
82NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.08208206
83BMI1_23680149_ChIP-Seq_NPCS_Mouse1.07936624
84THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.07683050
85GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.07178761
86GBX2_23144817_ChIP-Seq_PC3_Human1.05231367
87* CBX2_27304074_Chip-Seq_ESCs_Mouse1.04765813
88SMC4_20622854_ChIP-Seq_HELA_Human1.04282240
89TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03748193
90FUS_26573619_Chip-Seq_HEK293_Human1.03231730
91ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.03131926
92E2F7_22180533_ChIP-Seq_HELA_Human1.03108952
93TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01910591
94KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.00294643
95NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.00293126
96SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.99145993
97OCT4_19829295_ChIP-Seq_ESCs_Human0.99077013
98MYC_19079543_ChIP-ChIP_MESCs_Mouse0.99075680
99* STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.99034970
100* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.97893958
101MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.97345782
102* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.96975874
103* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96346388
104KDM2B_26808549_Chip-Seq_JURKAT_Human0.95519036
105WT1_25993318_ChIP-Seq_PODOCYTE_Human0.95221832
106SOX2_18555785_ChIP-Seq_MESCs_Mouse0.94287380
107RNF2_27304074_Chip-Seq_NSC_Mouse0.94001699
108RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.93110948
109TTF2_22483619_ChIP-Seq_HELA_Human0.92078207
110NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.91583977
111TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.91110005
112FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.90973890
113RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90732512
114* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.90252253
115* TET1_21451524_ChIP-Seq_MESCs_Mouse0.89247154
116UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.88656492
117NR3C1_23031785_ChIP-Seq_PC12_Mouse0.88237898
118SOX9_26525672_Chip-Seq_HEART_Mouse0.88236639
119MYC_27129775_Chip-Seq_CORNEA_Mouse0.88201754
120* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.88022639
121SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.87859100
122TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.87668869
123POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.87596823
124CREB1_26743006_Chip-Seq_LNCaP_Human0.86366980
125YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.85775395
126KDM2B_26808549_Chip-Seq_DND41_Human0.82938334
127ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.80204784
128SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.79873815
129SOX3_22085726_ChIP-Seq_NPCs_Mouse0.79696990
130PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.79628001
131E2F1_20622854_ChIP-Seq_HELA_Human0.79558101
132NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.79395957
133KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.79379619
134YY1_22570637_ChIP-Seq_MALME-3M_Human0.78879708
135DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.78679711
136EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.76674526
137SALL1_21062744_ChIP-ChIP_HESCs_Human0.76292320
138GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75592538

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.02198975
2MP0005645_abnormal_hypothalamus_physiol3.54970313
3MP0002822_catalepsy3.47804200
4MP0003635_abnormal_synaptic_transmissio3.44440636
5MP0003880_abnormal_central_pattern3.32073933
6MP0004858_abnormal_nervous_system3.12497976
7MP0000566_synostosis2.95556522
8MP0002063_abnormal_learning/memory/cond2.88436192
9MP0005423_abnormal_somatic_nervous2.86433920
10MP0003122_maternal_imprinting2.79757156
11MP0009745_abnormal_behavioral_response2.68980084
12MP0009046_muscle_twitch2.65132572
13MP0002064_seizures2.60859592
14MP0000049_abnormal_middle_ear2.59847121
15MP0003329_amyloid_beta_deposits2.59152928
16MP0005503_abnormal_tendon_morphology2.56417243
17MP0004270_analgesia2.53746263
18MP0005646_abnormal_pituitary_gland2.50274706
19MP0002572_abnormal_emotion/affect_behav2.48109772
20MP0004142_abnormal_muscle_tone2.32697163
21MP0002733_abnormal_thermal_nociception2.31742511
22MP0003385_abnormal_body_wall2.26074600
23MP0001968_abnormal_touch/_nociception2.26042253
24MP0000955_abnormal_spinal_cord2.18072384
25MP0008789_abnormal_olfactory_epithelium2.17299738
26MP0008438_abnormal_cutaneous_collagen2.16025666
27MP0009250_abnormal_appendicular_skeleto2.14628519
28MP0004233_abnormal_muscle_weight2.13503780
29MP0001348_abnormal_lacrimal_gland2.12553040
30* MP0002184_abnormal_innervation2.12347211
31MP0000537_abnormal_urethra_morphology2.08980266
32MP0001346_abnormal_lacrimal_gland2.08186473
33MP0002734_abnormal_mechanical_nocicepti2.01405811
34MP0001970_abnormal_pain_threshold2.00946356
35MP0002272_abnormal_nervous_system2.00185131
36MP0000751_myopathy1.97750405
37MP0001440_abnormal_grooming_behavior1.94593521
38MP0000778_abnormal_nervous_system1.93329191
39MP0003938_abnormal_ear_development1.91533634
40MP0006276_abnormal_autonomic_nervous1.89735861
41MP0000003_abnormal_adipose_tissue1.89735310
42MP0002233_abnormal_nose_morphology1.87352126
43MP0002557_abnormal_social/conspecific_i1.85198922
44MP0005275_abnormal_skin_tensile1.81326605
45MP0003937_abnormal_limbs/digits/tail_de1.78203143
46MP0004811_abnormal_neuron_physiology1.76243890
47MP0001501_abnormal_sleep_pattern1.73454517
48MP0002938_white_spotting1.71577007
49MP0001486_abnormal_startle_reflex1.70528124
50MP0006072_abnormal_retinal_apoptosis1.69368899
51MP0003755_abnormal_palate_morphology1.68981943
52MP0005386_behavior/neurological_phenoty1.68816505
53MP0004924_abnormal_behavior1.68816505
54MP0002932_abnormal_joint_morphology1.66847826
55MP0001299_abnormal_eye_distance/1.66780980
56MP0002116_abnormal_craniofacial_bone1.66417910
57MP0002697_abnormal_eye_size1.66145709
58MP0002067_abnormal_sensory_capabilities1.58715936
59MP0001502_abnormal_circadian_rhythm1.55885436
60MP0005171_absent_coat_pigmentation1.55058334
61MP0003283_abnormal_digestive_organ1.54899031
62MP0001188_hyperpigmentation1.54847374
63MP0002249_abnormal_larynx_morphology1.54219022
64* MP0002882_abnormal_neuron_morphology1.52768393
65MP0005394_taste/olfaction_phenotype1.48388992
66MP0005499_abnormal_olfactory_system1.48388992
67MP0003115_abnormal_respiratory_system1.45153599
68MP0002909_abnormal_adrenal_gland1.44714279
69MP0002066_abnormal_motor_capabilities/c1.36423585
70MP0000733_abnormal_muscle_development1.36212608
71MP0000428_abnormal_craniofacial_morphol1.35751435
72MP0008569_lethality_at_weaning1.34975772
73MP0001529_abnormal_vocalization1.34008975
74MP0002111_abnormal_tail_morphology1.32729290
75MP0002735_abnormal_chemical_nociception1.28931826
76MP0003119_abnormal_digestive_system1.28578503
77MP0005248_abnormal_Harderian_gland1.27557344
78MP0000762_abnormal_tongue_morphology1.24041053
79MP0001286_abnormal_eye_development1.23656034
80MP0002163_abnormal_gland_morphology1.23475247
81MP0003634_abnormal_glial_cell1.23161886
82MP0003935_abnormal_craniofacial_develop1.22974379
83MP0008872_abnormal_physiological_respon1.22489990
84MP0002114_abnormal_axial_skeleton1.18973363
85MP0003690_abnormal_glial_cell1.17557325
86MP0002638_abnormal_pupillary_reflex1.17304632
87MP0002152_abnormal_brain_morphology1.14804949
88MP0000604_amyloidosis1.14738122
89MP0002009_preneoplasia1.14309404
90MP0002653_abnormal_ependyma_morphology1.13028946
91MP0003787_abnormal_imprinting1.12556352
92MP0002108_abnormal_muscle_morphology1.10459160
93MP0002751_abnormal_autonomic_nervous1.09562813
94MP0001984_abnormal_olfaction1.07204175
95MP0005257_abnormal_intraocular_pressure1.06925161
96MP0003137_abnormal_impulse_conducting1.06774734
97MP0000631_abnormal_neuroendocrine_gland1.05090271
98MP0003633_abnormal_nervous_system1.03915475
99MP0006292_abnormal_olfactory_placode1.02833731
100MP0005197_abnormal_uvea_morphology1.02487105
101MP0009053_abnormal_anal_canal1.01653969
102* MP0002752_abnormal_somatic_nervous1.01589346
103MP0009703_decreased_birth_body1.00470315
104MP0002736_abnormal_nociception_after1.00440127
105MP0002269_muscular_atrophy1.00019413
106MP0003631_nervous_system_phenotype0.99455843
107MP0000026_abnormal_inner_ear0.99382630
108MP0000432_abnormal_head_morphology0.97629959
109MP0005508_abnormal_skeleton_morphology0.95798181
110MP0004133_heterotaxia0.95703476
111MP0000639_abnormal_adrenal_gland0.95629118
112* MP0002081_perinatal_lethality0.95378398
113MP0003075_altered_response_to0.94922453
114MP0008961_abnormal_basal_metabolism0.94411573
115MP0002109_abnormal_limb_morphology0.93799061
116MP0005083_abnormal_biliary_tract0.93249569
117MP0009672_abnormal_birth_weight0.92822321
118MP0002084_abnormal_developmental_patter0.92446815
119MP0005379_endocrine/exocrine_gland_phen0.91935304
120MP0002332_abnormal_exercise_endurance0.91453641
121MP0003123_paternal_imprinting0.90047180
122MP0003632_abnormal_nervous_system0.89731722
123MP0010030_abnormal_orbit_morphology0.89498040
124MP0002102_abnormal_ear_morphology0.89353383
125MP0002282_abnormal_trachea_morphology0.87905137
126MP0005253_abnormal_eye_physiology0.86280574
127MP0002092_abnormal_eye_morphology0.85129370
128MP0008057_abnormal_DNA_replication0.84739868
129MP0003121_genomic_imprinting0.83095563
130MP0002069_abnormal_eating/drinking_beha0.82509057
131MP0008877_abnormal_DNA_methylation0.82061012
132MP0002085_abnormal_embryonic_tissue0.81719762
133MP0003861_abnormal_nervous_system0.81275102
134MP0003942_abnormal_urinary_system0.81202405
135MP0000534_abnormal_ureter_morphology0.80863955
136MP0004885_abnormal_endolymph0.80399043
137MP0003567_abnormal_fetal_cardiomyocyte0.80377520
138MP0002090_abnormal_vision0.80161048
139MP0001340_abnormal_eyelid_morphology0.78769514
140MP0000013_abnormal_adipose_tissue0.78422293
141MP0001905_abnormal_dopamine_level0.78217392
142MP0000462_abnormal_digestive_system0.78167346
143* MP0001177_atelectasis0.77912043
144MP0003172_abnormal_lysosome_physiology0.77744891
145MP0002229_neurodegeneration0.76902158
146MP0001324_abnormal_eye_pigmentation0.75378231
147MP0005076_abnormal_cell_differentiation0.75246382
148MP0005187_abnormal_penis_morphology0.74690620
149MP0008932_abnormal_embryonic_tissue0.73696286
150* MP0001943_abnormal_respiration0.73109872
151MP0001849_ear_inflammation0.70839910
152MP0000163_abnormal_cartilage_morphology0.70049549
153MP0005391_vision/eye_phenotype0.70024531
154MP0000538_abnormal_urinary_bladder0.69949654
155MP0001293_anophthalmia0.68935812
156MP0008058_abnormal_DNA_repair0.68406319
157MP0000579_abnormal_nail_morphology0.63924026
158MP0000747_muscle_weakness0.63220041
159MP0005551_abnormal_eye_electrophysiolog0.60460075
160MP0005448_abnormal_energy_balance0.60276977
161MP0005623_abnormal_meninges_morphology0.60051728
162MP0010769_abnormal_survival0.59584702
163MP0003890_abnormal_embryonic-extraembry0.59477582
164MP0003638_abnormal_response/metabolism_0.59421309

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.80032926
2Focal motor seizures (HP:0011153)3.94278480
3Visual hallucinations (HP:0002367)3.71134340
4Focal seizures (HP:0007359)3.60883466
5Pheochromocytoma (HP:0002666)3.55049339
6Polyphagia (HP:0002591)3.54972498
7Growth hormone excess (HP:0000845)3.50377543
8Premature rupture of membranes (HP:0001788)3.41641850
9Abnormality of the ischium (HP:0003174)3.38787397
10Annular pancreas (HP:0001734)3.38121140
11Rectal fistula (HP:0100590)3.36799013
12Rectovaginal fistula (HP:0000143)3.36799013
13Cerebellar dysplasia (HP:0007033)3.35025035
14Agitation (HP:0000713)3.33867217
15Vaginal fistula (HP:0004320)3.32785666
16Megalencephaly (HP:0001355)3.31212718
17Ankle clonus (HP:0011448)3.26810223
18Hypercortisolism (HP:0001578)3.21690910
19Turricephaly (HP:0000262)3.21060359
20Narrow nasal bridge (HP:0000446)3.17175721
21Supranuclear gaze palsy (HP:0000605)3.15839265
22Cutaneous finger syndactyly (HP:0010554)3.14679133
23Concave nail (HP:0001598)3.05201571
24Short 4th metacarpal (HP:0010044)3.02618275
25Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.02618275
26Bell-shaped thorax (HP:0001591)2.97053104
27Abnormal eating behavior (HP:0100738)2.93931661
28Neuroendocrine neoplasm (HP:0100634)2.93818306
29Failure to thrive in infancy (HP:0001531)2.93472609
30Cutaneous syndactyly (HP:0012725)2.89934974
31Poor suck (HP:0002033)2.88742955
32Atonic seizures (HP:0010819)2.88204141
33Abnormality of dentin (HP:0010299)2.87733875
34Menstrual irregularities (HP:0000858)2.87339880
35Intestinal fistula (HP:0100819)2.86370937
36Absence seizures (HP:0002121)2.80703428
37Hypoplastic ischia (HP:0003175)2.77561234
38Abnormality of the 4th metacarpal (HP:0010012)2.73143844
39Neurofibrillary tangles (HP:0002185)2.72763790
40Epileptic encephalopathy (HP:0200134)2.71444132
41Orthostatic hypotension (HP:0001278)2.70962847
42Abnormality of the lower motor neuron (HP:0002366)2.61802506
43Anxiety (HP:0000739)2.60775309
44Febrile seizures (HP:0002373)2.57403224
45Action tremor (HP:0002345)2.52706157
46Abnormality of the labia minora (HP:0012880)2.52314469
47Wide anterior fontanel (HP:0000260)2.49112183
48Depression (HP:0000716)2.49104838
49Abnormality of the parietal bone (HP:0002696)2.49052811
50Arterial tortuosity (HP:0005116)2.48808127
51Aplasia of the musculature (HP:0100854)2.41666762
52Vitreoretinal degeneration (HP:0000655)2.41609917
53Aplasia cutis congenita (HP:0001057)2.39142611
54Alacrima (HP:0000522)2.37945677
55Cerebral inclusion bodies (HP:0100314)2.37767527
56Dialeptic seizures (HP:0011146)2.36567729
57Ulnar bowing (HP:0003031)2.36433577
58Dysdiadochokinesis (HP:0002075)2.36063902
59Bladder diverticulum (HP:0000015)2.36007666
60Progressive cerebellar ataxia (HP:0002073)2.35745561
61Clumsiness (HP:0002312)2.34818494
62Aqueductal stenosis (HP:0002410)2.33038934
63Partial agenesis of the corpus callosum (HP:0001338)2.32965522
64Thin ribs (HP:0000883)2.31403367
65Diaphragmatic weakness (HP:0009113)2.31150009
66Infantile muscular hypotonia (HP:0008947)2.30895950
67Urinary urgency (HP:0000012)2.30776956
68Mild short stature (HP:0003502)2.30692562
69Impaired vibration sensation in the lower limbs (HP:0002166)2.30201494
70Abnormality of the aortic arch (HP:0012303)2.29651047
71Midline defect of the nose (HP:0004122)2.28672724
72Psychosis (HP:0000709)2.26334698
73* Calcaneovalgus deformity (HP:0001848)2.25965750
74Renal duplication (HP:0000075)2.25726235
75Shallow orbits (HP:0000586)2.24537963
76Broad alveolar ridges (HP:0000187)2.24457054
77Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.23360257
78Abnormality of the phalanges of the 2nd finger (HP:0009541)2.21501981
79Generalized tonic-clonic seizures (HP:0002069)2.20665179
80Restlessness (HP:0000711)2.19485237
81Coronal craniosynostosis (HP:0004440)2.16423105
82Genu recurvatum (HP:0002816)2.13940306
83Increased number of teeth (HP:0011069)2.11851728
84Neoplasm of the peripheral nervous system (HP:0100007)2.11659451
85Abnormality of the corticospinal tract (HP:0002492)2.11430851
86Protrusio acetabuli (HP:0003179)2.11304382
87Vascular tortuosity (HP:0004948)2.11143325
88Urinary bladder sphincter dysfunction (HP:0002839)2.10756699
89Abnormal number of incisors (HP:0011064)2.10171141
90Intention tremor (HP:0002080)2.09454600
91Broad metatarsal (HP:0001783)2.08637157
92Lower limb muscle weakness (HP:0007340)2.07197317
93Gait imbalance (HP:0002141)2.05825159
94Mutism (HP:0002300)2.05012429
95Spastic gait (HP:0002064)2.04923118
96Dysmetria (HP:0001310)2.03421540
97Specific learning disability (HP:0001328)2.03380349
98Clonus (HP:0002169)2.01698005
99Hemiparesis (HP:0001269)2.01679516
100Trigonocephaly (HP:0000243)1.99167578
101Overriding aorta (HP:0002623)1.98321770
102Torticollis (HP:0000473)1.96682876
103Hypoventilation (HP:0002791)1.96236574
104Insomnia (HP:0100785)1.94774002
105Tracheomalacia (HP:0002779)1.93950712
106Aortic dissection (HP:0002647)1.93515343
107Termporal pattern (HP:0011008)1.93407596
108Insidious onset (HP:0003587)1.93407596
109Abnormality of the middle phalanges of the toes (HP:0010183)1.92551399
110Cerebral aneurysm (HP:0004944)1.92298805
111Exostoses (HP:0100777)1.91998072
112Decreased lacrimation (HP:0000633)1.91106336
113Absent epiphyses (HP:0010577)1.91013978
114Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.91013978
115Bronchomalacia (HP:0002780)1.90429415
116Soft skin (HP:0000977)1.90001919
117Morphological abnormality of the middle ear (HP:0008609)1.88794048
118Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.88775637
119Mitral valve prolapse (HP:0001634)1.88398070
120Fetal akinesia sequence (HP:0001989)1.87991246
121Anteriorly placed anus (HP:0001545)1.87159978
122Ulnar claw (HP:0001178)1.86834499
123Broad toe (HP:0001837)1.86599883
124Hypsarrhythmia (HP:0002521)1.86161836
125Exercise-induced myalgia (HP:0003738)1.86064162
126Deviation of the hallux (HP:0010051)1.85204685
127Progressive inability to walk (HP:0002505)1.84588439
128Tongue fasciculations (HP:0001308)1.84299217
129EEG with generalized epileptiform discharges (HP:0011198)1.83820448
130* Deformed tarsal bones (HP:0008119)1.83226851
131Retinal atrophy (HP:0001105)1.82565899
132Hallux valgus (HP:0001822)1.82299392
133Truncal ataxia (HP:0002078)1.81969256
134High anterior hairline (HP:0009890)1.81199505
135Synostosis of carpal bones (HP:0005048)1.80743419
136Lip pit (HP:0100267)1.80033488
137Generalized hypotonia (HP:0001290)1.79328556
138Sacral dimple (HP:0000960)1.79184879
139Biconcave vertebral bodies (HP:0004586)1.77881928
140Abnormal EKG (HP:0003115)1.77669739
141Thoracolumbar scoliosis (HP:0002944)1.77472095
142Hypoplastic pelvis (HP:0008839)1.77082135
143Epileptiform EEG discharges (HP:0011182)1.76758163
144Humeroradial synostosis (HP:0003041)1.76313237
145Synostosis involving the elbow (HP:0003938)1.76313237
146Rib fusion (HP:0000902)1.75904861
147Limb dystonia (HP:0002451)1.74665683
148Septate vagina (HP:0001153)1.74456392
149Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.74417570
150Morphological abnormality of the pyramidal tract (HP:0002062)1.73122617
151Facial hemangioma (HP:0000329)1.72652204
152Nasal speech (HP:0001611)1.72207820
153Peritonitis (HP:0002586)1.72162077
154Muscle fibrillation (HP:0010546)1.71321388
155Hemiplegia (HP:0002301)1.70128034
156Amblyopia (HP:0000646)1.69439838
157Focal dystonia (HP:0004373)1.68799857
158Pterygium (HP:0001059)1.68572095
159Lower limb amyotrophy (HP:0007210)1.68124051
160Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.67900508
161Thin bony cortex (HP:0002753)1.67594265
162Thickened helices (HP:0000391)1.66921497
163Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.66578610
164Aplasia/Hypoplasia of the sacrum (HP:0008517)1.66032370
165* Abnormality of the calcaneus (HP:0008364)1.65939611
166Renal hypoplasia (HP:0000089)1.64748511
167Oligodactyly (hands) (HP:0001180)1.64681521
168Craniofacial dystonia (HP:0012179)1.63845405
169Hepatoblastoma (HP:0002884)1.62279912
170Atresia of the external auditory canal (HP:0000413)1.62132137
171Carpal synostosis (HP:0009702)1.62045250
172Delayed epiphyseal ossification (HP:0002663)1.62035121
173Short metatarsal (HP:0010743)1.61699188
174Bowel diverticulosis (HP:0005222)1.61074733
175Short palpebral fissure (HP:0012745)1.59434008
176Preaxial foot polydactyly (HP:0001841)1.59245576
177Oligodactyly (HP:0012165)1.58661693
178Chin dimple (HP:0010751)1.58513729
179Fragile skin (HP:0001030)1.57578704
180Broad finger (HP:0001500)1.56766194
181Atrophic scars (HP:0001075)1.56607127
182Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.56550229
183Vertebral fusion (HP:0002948)1.55603630
184Abnormality of incisor morphology (HP:0011063)1.54638538
185Broad distal phalanx of finger (HP:0009836)1.54130323
186Broad palm (HP:0001169)1.53012792
187Congenital diaphragmatic hernia (HP:0000776)1.52876283

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK27.43941303
2MAP3K93.46971537
3NTRK33.24585197
4MARK13.21290528
5ICK3.17582172
6DDR23.03491615
7EEF2K3.03236936
8NTRK22.86882523
9PHKG12.77566033
10PHKG22.77566033
11MST1R2.61513659
12FGFR22.52911613
13TYRO32.50918197
14LMTK22.37230232
15UHMK12.35144404
16FGR2.34158039
17MINK12.22166780
18CASK2.15092227
19EPHA42.11997112
20MAP3K62.00863148
21MAP3K111.94237855
22PINK11.84285141
23SCYL21.82226034
24MAPK151.80387563
25LATS11.79010870
26MKNK11.75641926
27EPHA31.71794763
28DAPK11.71489826
29PAK61.71015492
30LATS21.70057791
31KSR21.68610486
32BMX1.65402805
33MAP3K121.64653908
34MAP3K41.63653877
35MATK1.59283695
36WNK41.59050869
37EPHB21.56211399
38PAK31.54175214
39MET1.53677176
40NTRK11.52400472
41PRPF4B1.50892655
42RIPK11.40976644
43PRKD31.37084169
44STK161.32870245
45LIMK11.32843825
46CDK51.31376999
47NEK61.30176691
48STK38L1.24858160
49BRD41.23995114
50CSNK1G11.23720029
51MAP3K101.22728269
52CSNK1A1L1.16825575
53STK391.16337950
54CDK121.11911765
55MAP2K71.10510640
56IRAK21.09830998
57MTOR1.07304274
58GRK71.04986815
59PNCK0.99928928
60CDC42BPA0.99019039
61NEK20.98286195
62PRKD20.97726109
63STK110.96502441
64STK380.96271370
65OXSR10.95522349
66KSR10.95302028
67ARAF0.95074574
68CAMK1G0.93763303
69DAPK20.92171400
70MAP2K40.90755079
71CAMKK10.83111131
72CAMK2A0.82719898
73CAMK2G0.82427422
74PDGFRA0.80491417
75CDK150.79524088
76CDK180.78409018
77MAPK130.77772780
78CDK140.77111869
79DYRK20.76810534
80PASK0.75617889
81CDK190.75396707
82SGK4940.75186470
83SGK2230.75186470
84IRAK10.73996562
85PRKCG0.73929253
86MAP3K20.73898813
87RAF10.72620708
88CAMK2B0.71468314
89CSNK1E0.70770314
90CDK11A0.70108167
91YES10.69933960
92RET0.69857158
93PBK0.69279408
94BRSK10.68606791
95ALK0.67277817
96MAP2K20.66852283
97MKNK20.65964975
98TTK0.65507373
99INSRR0.64532094
100PDK40.64164506
101PDK30.64164506
102DYRK1A0.63616964
103CDC70.61787149
104MAP3K70.60283016
105DYRK1B0.59114456
106TLK10.58910857
107GRK50.58551133
108AURKA0.57920684
109DYRK30.57715417
110CDK20.55907905
111PRKCZ0.54861786
112ATR0.53965037
113CDK10.53631462
114SIK20.53556885
115SGK10.53477018
116PIM20.52526283
117ERBB30.52277387
118TAOK10.51628387
119CHEK10.50639804
120ZAK0.50098106
121TNIK0.49971366
122GSK3B0.49438762
123NME10.49377750
124FGFR10.49297660
125TAOK20.48338135
126RPS6KC10.47548015
127RPS6KL10.47548015
128CSNK1G20.47383132
129MAPK140.47012838
130CDK80.46649519
131NEK10.46468234
132MAPK100.46139608
133ERBB20.45856228
134CAMK2D0.45738660
135MAP3K130.44945750
136CAMK1D0.44082986
137MAPK80.43694209
138HIPK20.43511417
139RPS6KA20.43037274
140PLK20.42339229
141AKT20.42147415
142FES0.41507027
143AURKB0.41338903
144PRKDC0.41109931
145MAPK40.40933875
146RPS6KB10.40864634
147TRIB30.40546264
148PRKAA10.40492416
149MAPKAPK50.39856501
150RPS6KA30.39657264
151RPS6KA10.39369723
152CSK0.39129486
153MARK20.38293536
154TESK10.37437382
155MAPK70.37112889
156CHEK20.36580732
157RPS6KA60.36237150
158TNK20.34913022
159MAPK90.34888656
160AKT10.34119225
161FER0.33660809
162SRPK10.33406487
163BCR0.33376639
164AKT30.33139334
165CSNK1G30.32935929
166PLK10.32793748
167TSSK60.32464997
168MAP3K10.30043809
169ADRBK10.29661743
170CDK30.29426474

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000613.49381824
2Synaptic vesicle cycle_Homo sapiens_hsa047213.40890841
3Nicotine addiction_Homo sapiens_hsa050333.14608015
4GABAergic synapse_Homo sapiens_hsa047272.74101758
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.56232857
6Olfactory transduction_Homo sapiens_hsa047402.33338573
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.18474128
8Amphetamine addiction_Homo sapiens_hsa050312.14628229
9Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.07009496
10Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.05874755
11Morphine addiction_Homo sapiens_hsa050322.02089241
12Dopaminergic synapse_Homo sapiens_hsa047281.92725909
13Circadian entrainment_Homo sapiens_hsa047131.92509855
14Glutamatergic synapse_Homo sapiens_hsa047241.85542539
15Protein digestion and absorption_Homo sapiens_hsa049741.81942866
16Cocaine addiction_Homo sapiens_hsa050301.79917103
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.77072265
18Cholinergic synapse_Homo sapiens_hsa047251.75587801
19Ribosome_Homo sapiens_hsa030101.73924678
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.70372836
21Long-term potentiation_Homo sapiens_hsa047201.70239054
22TGF-beta signaling pathway_Homo sapiens_hsa043501.67300063
23Gap junction_Homo sapiens_hsa045401.61080621
24Insulin secretion_Homo sapiens_hsa049111.56301451
25Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.52787394
26Central carbon metabolism in cancer_Homo sapiens_hsa052301.51402240
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.45035464
28Axon guidance_Homo sapiens_hsa043601.42796462
29Collecting duct acid secretion_Homo sapiens_hsa049661.40842617
30Salivary secretion_Homo sapiens_hsa049701.38898923
31Gastric acid secretion_Homo sapiens_hsa049711.31243467
32GnRH signaling pathway_Homo sapiens_hsa049121.30727537
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.29691296
34Hedgehog signaling pathway_Homo sapiens_hsa043401.27674202
35Renin secretion_Homo sapiens_hsa049241.27163396
36Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.27143360
37Long-term depression_Homo sapiens_hsa047301.27067438
38Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.26338226
39ErbB signaling pathway_Homo sapiens_hsa040121.23198884
40Serotonergic synapse_Homo sapiens_hsa047261.22725368
41Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.20495669
42Sulfur relay system_Homo sapiens_hsa041221.19782628
43Estrogen signaling pathway_Homo sapiens_hsa049151.16019310
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.15573726
45Oxytocin signaling pathway_Homo sapiens_hsa049211.12327702
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.12031130
47Oocyte meiosis_Homo sapiens_hsa041141.11010593
48Vibrio cholerae infection_Homo sapiens_hsa051101.10924375
49Melanogenesis_Homo sapiens_hsa049161.10155265
50Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.09213613
51mRNA surveillance pathway_Homo sapiens_hsa030151.07787832
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.05633803
53Aldosterone synthesis and secretion_Homo sapiens_hsa049251.05521590
54Prion diseases_Homo sapiens_hsa050201.04552157
55Cardiac muscle contraction_Homo sapiens_hsa042601.04448065
56ECM-receptor interaction_Homo sapiens_hsa045121.03667707
57RNA transport_Homo sapiens_hsa030131.03062356
58Fatty acid metabolism_Homo sapiens_hsa012121.02694216
59Lysine degradation_Homo sapiens_hsa003101.02648385
60Circadian rhythm_Homo sapiens_hsa047101.02468993
61Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.02400697
62Taste transduction_Homo sapiens_hsa047421.02302300
63Non-homologous end-joining_Homo sapiens_hsa034501.02167644
64Butanoate metabolism_Homo sapiens_hsa006501.00384270
65VEGF signaling pathway_Homo sapiens_hsa043700.96904655
66Calcium signaling pathway_Homo sapiens_hsa040200.96542575
67Hippo signaling pathway_Homo sapiens_hsa043900.96034447
68Pathways in cancer_Homo sapiens_hsa052000.95716351
69Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.95561399
70Cell cycle_Homo sapiens_hsa041100.95320693
71Type I diabetes mellitus_Homo sapiens_hsa049400.93401666
72Dorso-ventral axis formation_Homo sapiens_hsa043200.92238829
73Choline metabolism in cancer_Homo sapiens_hsa052310.90775758
74Spliceosome_Homo sapiens_hsa030400.90596937
75Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90181170
76mTOR signaling pathway_Homo sapiens_hsa041500.89821740
77Nitrogen metabolism_Homo sapiens_hsa009100.89579876
78Wnt signaling pathway_Homo sapiens_hsa043100.88993683
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.88906169
80Pyruvate metabolism_Homo sapiens_hsa006200.84438803
81Vitamin B6 metabolism_Homo sapiens_hsa007500.84429009
82cAMP signaling pathway_Homo sapiens_hsa040240.83799349
83Carbon metabolism_Homo sapiens_hsa012000.83298506
84Small cell lung cancer_Homo sapiens_hsa052220.82645167
85Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.79270937
86Fanconi anemia pathway_Homo sapiens_hsa034600.78761249
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77246983
88Nucleotide excision repair_Homo sapiens_hsa034200.75832716
89MAPK signaling pathway_Homo sapiens_hsa040100.75610862
90Biosynthesis of amino acids_Homo sapiens_hsa012300.73113905
91Phenylalanine metabolism_Homo sapiens_hsa003600.72872131
92Insulin signaling pathway_Homo sapiens_hsa049100.72525656
93Glioma_Homo sapiens_hsa052140.70712244
94Fatty acid elongation_Homo sapiens_hsa000620.69429452
95Bile secretion_Homo sapiens_hsa049760.68700685
96Ovarian steroidogenesis_Homo sapiens_hsa049130.68147614
97Steroid biosynthesis_Homo sapiens_hsa001000.67632100
98Basal cell carcinoma_Homo sapiens_hsa052170.66316030
99Adherens junction_Homo sapiens_hsa045200.66304118
100MicroRNAs in cancer_Homo sapiens_hsa052060.66125007
101Purine metabolism_Homo sapiens_hsa002300.64638663
102Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64493729
103Colorectal cancer_Homo sapiens_hsa052100.61583643
104Arginine and proline metabolism_Homo sapiens_hsa003300.60852750
105Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.60658681
106Neurotrophin signaling pathway_Homo sapiens_hsa047220.60122001
107Selenocompound metabolism_Homo sapiens_hsa004500.60075089
108Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.59800572
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59428158
110Parkinsons disease_Homo sapiens_hsa050120.57596013
111Cysteine and methionine metabolism_Homo sapiens_hsa002700.57273688
112DNA replication_Homo sapiens_hsa030300.56328701
113Glucagon signaling pathway_Homo sapiens_hsa049220.55324031
114Basal transcription factors_Homo sapiens_hsa030220.55070829
115AMPK signaling pathway_Homo sapiens_hsa041520.54756626
116Amoebiasis_Homo sapiens_hsa051460.54147863
117Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53304676
118Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.53303798
119PI3K-Akt signaling pathway_Homo sapiens_hsa041510.52125917
120Type II diabetes mellitus_Homo sapiens_hsa049300.51726255
121Endometrial cancer_Homo sapiens_hsa052130.50249344
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.49939852
123Alzheimers disease_Homo sapiens_hsa050100.49887600
124Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.49301494
125Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.49121813
126Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.49120869
127Arginine biosynthesis_Homo sapiens_hsa002200.46908078
128Notch signaling pathway_Homo sapiens_hsa043300.46444708
129Huntingtons disease_Homo sapiens_hsa050160.46140531
130Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44245714
131Endocytosis_Homo sapiens_hsa041440.44185347
132Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.44057147
133Alcoholism_Homo sapiens_hsa050340.44004593
134Phospholipase D signaling pathway_Homo sapiens_hsa040720.43983753
135Regulation of autophagy_Homo sapiens_hsa041400.43610985
136Bladder cancer_Homo sapiens_hsa052190.43285344
137Melanoma_Homo sapiens_hsa052180.42359363
138Dilated cardiomyopathy_Homo sapiens_hsa054140.42358894
139Chronic myeloid leukemia_Homo sapiens_hsa052200.40100081
140Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40028083
141Thyroid hormone synthesis_Homo sapiens_hsa049180.37158607
142Oxidative phosphorylation_Homo sapiens_hsa001900.34897866
143Phosphatidylinositol signaling system_Homo sapiens_hsa040700.34577207
144Ras signaling pathway_Homo sapiens_hsa040140.34448178
145Thyroid cancer_Homo sapiens_hsa052160.32340191
146Rap1 signaling pathway_Homo sapiens_hsa040150.31737120
147cGMP-PKG signaling pathway_Homo sapiens_hsa040220.30685655

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