ECH1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the hydratase/isomerase superfamily. The gene product shows high sequence similarity to enoyl-coenzyme A (CoA) hydratases of several species, particularly within a conserved domain characteristic of these proteins. The encoded protein, which contains a C-terminal peroxisomal targeting sequence, localizes to the peroxisome. The rat ortholog, which localizes to the matrix of both the peroxisome and mitochondria, can isomerize 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA, indicating that it is a delta3,5-delta2,4-dienoyl-CoA isomerase. This enzyme functions in the auxiliary step of the fatty acid beta-oxidation pathway. Expression of the rat gene is induced by peroxisome proliferators. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* fatty acid beta-oxidation (GO:0006635)5.35003733
2lysine metabolic process (GO:0006553)5.25660708
3lysine catabolic process (GO:0006554)5.25660708
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.21957782
5L-phenylalanine catabolic process (GO:0006559)5.21957782
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.13685485
7L-phenylalanine metabolic process (GO:0006558)5.13685485
8glyoxylate metabolic process (GO:0046487)4.98502167
9tricarboxylic acid cycle (GO:0006099)4.89565910
10regulation of sequestering of triglyceride (GO:0010889)4.81865289
11* fatty acid oxidation (GO:0019395)4.80504121
12fatty acid transmembrane transport (GO:1902001)4.80356806
13fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.78868360
14* fatty acid catabolic process (GO:0009062)4.77615876
15carnitine shuttle (GO:0006853)4.75407210
162-oxoglutarate metabolic process (GO:0006103)4.75162156
17* lipid oxidation (GO:0034440)4.72315352
18energy coupled proton transport, down electrochemical gradient (GO:0015985)4.69323493
19ATP synthesis coupled proton transport (GO:0015986)4.69323493
20short-chain fatty acid metabolic process (GO:0046459)4.68094607
21acetyl-CoA metabolic process (GO:0006084)4.67911502
22branched-chain amino acid catabolic process (GO:0009083)4.63255356
23cellular ketone body metabolic process (GO:0046950)4.61160089
24alpha-linolenic acid metabolic process (GO:0036109)4.53507767
25aspartate family amino acid catabolic process (GO:0009068)4.48497535
26valine metabolic process (GO:0006573)4.48212606
27aromatic amino acid family catabolic process (GO:0009074)4.46530951
28regulation of triglyceride catabolic process (GO:0010896)4.42635793
29amino-acid betaine metabolic process (GO:0006577)4.35231354
30* monocarboxylic acid catabolic process (GO:0072329)4.31769515
31branched-chain amino acid metabolic process (GO:0009081)4.30965372
32carnitine metabolic process (GO:0009437)4.22507958
33triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.20470580
34kynurenine metabolic process (GO:0070189)4.16227245
35deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.08886808
36ethanol oxidation (GO:0006069)4.07946147
37protein complex biogenesis (GO:0070271)4.07772922
38biotin metabolic process (GO:0006768)3.98767141
39ketone body metabolic process (GO:1902224)3.98085860
40sulfur amino acid catabolic process (GO:0000098)3.93135826
41bile acid biosynthetic process (GO:0006699)3.86875539
42tricarboxylic acid metabolic process (GO:0072350)3.86552716
43carnitine transmembrane transport (GO:1902603)3.86476345
44amino-acid betaine transport (GO:0015838)3.86036210
45carnitine transport (GO:0015879)3.86036210
46cysteine metabolic process (GO:0006534)3.85603905
47tryptophan catabolic process (GO:0006569)3.85038367
48indole-containing compound catabolic process (GO:0042436)3.85038367
49indolalkylamine catabolic process (GO:0046218)3.85038367
50regulation of fatty acid oxidation (GO:0046320)3.84607268
51positive regulation of fatty acid beta-oxidation (GO:0032000)3.78137925
52mitochondrial respiratory chain complex assembly (GO:0033108)3.77583074
53regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.77275610
54NADH metabolic process (GO:0006734)3.77005235
55DNA deamination (GO:0045006)3.74736791
56positive regulation of fatty acid oxidation (GO:0046321)3.73576592
57mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.68544250
58mitochondrial respiratory chain complex I assembly (GO:0032981)3.68544250
59NADH dehydrogenase complex assembly (GO:0010257)3.68544250
60succinate metabolic process (GO:0006105)3.64678391
61* carboxylic acid catabolic process (GO:0046395)3.63850544
62* organic acid catabolic process (GO:0016054)3.63850544
63tryptophan metabolic process (GO:0006568)3.62080299
64alpha-amino acid catabolic process (GO:1901606)3.56076081
65actin-myosin filament sliding (GO:0033275)3.55266849
66muscle filament sliding (GO:0030049)3.55266849
67thioester metabolic process (GO:0035383)3.51530232
68acyl-CoA metabolic process (GO:0006637)3.51530232
69regulation of cholesterol metabolic process (GO:0090181)3.49383910
70homocysteine metabolic process (GO:0050667)3.48556512
71regulation of mitochondrial translation (GO:0070129)3.48244649
72regulation of cellular amino acid metabolic process (GO:0006521)3.48243850
73respiratory chain complex IV assembly (GO:0008535)3.47720111
74thioester biosynthetic process (GO:0035384)3.45183552
75acyl-CoA biosynthetic process (GO:0071616)3.45183552
76cellular amino acid catabolic process (GO:0009063)3.45056927
77plasma lipoprotein particle clearance (GO:0034381)3.44941191
78quaternary ammonium group transport (GO:0015697)3.41967484
79acylglycerol homeostasis (GO:0055090)3.41695043
80triglyceride homeostasis (GO:0070328)3.41695043
81cytochrome complex assembly (GO:0017004)3.40947453
82serine family amino acid catabolic process (GO:0009071)3.40825483
83regulation of acyl-CoA biosynthetic process (GO:0050812)3.36778985
84mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.35506236
85cytidine deamination (GO:0009972)3.35112459
86cytidine metabolic process (GO:0046087)3.35112459
87cytidine catabolic process (GO:0006216)3.35112459
88respiratory electron transport chain (GO:0022904)3.34281664
89oxaloacetate metabolic process (GO:0006107)3.32739111
90positive regulation of lipid catabolic process (GO:0050996)3.31525917
91complement activation, alternative pathway (GO:0006957)3.30659387
92phospholipid homeostasis (GO:0055091)3.30110311
93coenzyme catabolic process (GO:0009109)3.28198393
94ubiquinone biosynthetic process (GO:0006744)3.28151618
95bile acid metabolic process (GO:0008206)3.25692150
96sarcomere organization (GO:0045214)3.25335671
97peptidyl-glutamic acid carboxylation (GO:0017187)3.24822560
98protein carboxylation (GO:0018214)3.24822560
99electron transport chain (GO:0022900)3.24684031
100aromatic amino acid family metabolic process (GO:0009072)3.23568687
101response to mercury ion (GO:0046689)3.21429705
102mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.19417584
103high-density lipoprotein particle remodeling (GO:0034375)3.18241713
104ethanol metabolic process (GO:0006067)3.18115825
105negative regulation of fatty acid biosynthetic process (GO:0045717)3.17806392
106aerobic respiration (GO:0009060)3.17282977
107urea cycle (GO:0000050)3.16988138
108urea metabolic process (GO:0019627)3.16988138
109creatine metabolic process (GO:0006600)3.15252426
110chaperone-mediated protein transport (GO:0072321)3.13932335
111ATP biosynthetic process (GO:0006754)3.09828112
112drug transmembrane transport (GO:0006855)3.09445252
113negative regulation of fibrinolysis (GO:0051918)3.08787961
114tyrosine metabolic process (GO:0006570)3.06302377
115* small molecule catabolic process (GO:0044282)3.05951533
116quinone biosynthetic process (GO:1901663)3.05395729
117nitrogen cycle metabolic process (GO:0071941)3.04352783
118oxidative phosphorylation (GO:0006119)3.03998566
119regulation of fatty acid beta-oxidation (GO:0031998)3.01830732
120DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.01667006
121negative regulation of lipase activity (GO:0060192)3.00452822
122regulation of cofactor metabolic process (GO:0051193)3.00286115
123regulation of coenzyme metabolic process (GO:0051196)3.00286115
124regulation of protein activation cascade (GO:2000257)3.00010180
125proteasome assembly (GO:0043248)2.96844386
126negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.95983770
127heme metabolic process (GO:0042168)2.91970701
128intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.89882966
129signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.89882966
130signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.88237883
131signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.88237883
132signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.88237883
133purine nucleoside triphosphate biosynthetic process (GO:0009145)2.87412577
134xenobiotic catabolic process (GO:0042178)2.86706351
135aldehyde catabolic process (GO:0046185)2.85507877
136purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.85343306
137protein maturation by protein folding (GO:0022417)2.84036822
138heme biosynthetic process (GO:0006783)2.82865854
139negative regulation of B cell apoptotic process (GO:0002903)2.82391687
140hydrogen ion transmembrane transport (GO:1902600)2.81323943
141establishment of protein localization to mitochondrial membrane (GO:0090151)2.80041548
142gluconeogenesis (GO:0006094)2.76767005
143positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.76564787
144daunorubicin metabolic process (GO:0044597)2.76358220
145polyketide metabolic process (GO:0030638)2.76358220
146doxorubicin metabolic process (GO:0044598)2.76358220
147ubiquinone metabolic process (GO:0006743)2.75344856
148signal transduction involved in DNA damage checkpoint (GO:0072422)2.74755090
149signal transduction involved in DNA integrity checkpoint (GO:0072401)2.74755090
150hydrogen peroxide catabolic process (GO:0042744)2.74727871
151antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.74495247
152purine nucleotide salvage (GO:0032261)2.74086973
153metallo-sulfur cluster assembly (GO:0031163)2.73806914
154iron-sulfur cluster assembly (GO:0016226)2.73806914
155deoxyribonucleotide catabolic process (GO:0009264)2.73782545
156purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.72729707
157purine deoxyribonucleotide catabolic process (GO:0009155)2.71019329
158mitochondrial transport (GO:0006839)2.70678623
159negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.67839187
160negative regulation of ligase activity (GO:0051352)2.67839187
161monosaccharide biosynthetic process (GO:0046364)2.67391722
162signal transduction involved in cell cycle checkpoint (GO:0072395)2.66589961
163quinone metabolic process (GO:1901661)2.65584153
164regulation of cellular amine metabolic process (GO:0033238)2.64457030
165regulation of cholesterol esterification (GO:0010872)2.64154763
166pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.63855100
167deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.62605547
168purine nucleoside monophosphate biosynthetic process (GO:0009127)2.62239451
169purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.62239451
170pyrimidine ribonucleoside catabolic process (GO:0046133)2.62058697
171actin-mediated cell contraction (GO:0070252)2.61653759
172glutathione derivative metabolic process (GO:1901685)2.61499416
173glutathione derivative biosynthetic process (GO:1901687)2.61499416

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.99020174
2* PPARG_19300518_ChIP-PET_3T3-L1_Mouse8.48751617
3RXR_22158963_ChIP-Seq_LIVER_Mouse6.24945435
4PPARA_22158963_ChIP-Seq_LIVER_Mouse5.56723686
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.99281194
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.38278206
7* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.16244592
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.09720912
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.55319991
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.50033024
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.40668893
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.34733855
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.16286713
14* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.10805107
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.68162653
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.49165418
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.47796222
18ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.46688580
19CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.42789482
20CLOCK_20551151_ChIP-Seq_293T_Human2.29937813
21MYC_18358816_ChIP-ChIP_MESCs_Mouse2.29559031
22* EST1_17652178_ChIP-ChIP_JURKAT_Human2.23254558
23TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.21716476
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.15955170
25CREB1_15753290_ChIP-ChIP_HEK293T_Human2.08585298
26RARG_19884340_ChIP-ChIP_MEFs_Mouse1.97382971
27HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.93948930
28GATA1_22025678_ChIP-Seq_K562_Human1.92049868
29* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.87771204
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.82694582
31MYC_18555785_ChIP-Seq_MESCs_Mouse1.82388360
32PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.77452923
33THAP11_20581084_ChIP-Seq_MESCs_Mouse1.77333201
34SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.72605641
35E2F1_18555785_ChIP-Seq_MESCs_Mouse1.71947197
36STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.71888747
37HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.70789414
38* YY1_21170310_ChIP-Seq_MESCs_Mouse1.69323935
39FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.68606605
40TBX20_22080862_ChIP-Seq_HEART_Mouse1.67114253
41TBX20_22328084_ChIP-Seq_HEART_Mouse1.67114253
42* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.66703436
43TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.63514578
44* FOXP3_21729870_ChIP-Seq_TREG_Human1.59012568
45EP300_21415370_ChIP-Seq_HL-1_Mouse1.56698629
46GABP_19822575_ChIP-Seq_HepG2_Human1.55793649
47* VDR_23849224_ChIP-Seq_CD4+_Human1.55396740
48THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.53025510
49RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.51081706
50ZNF263_19887448_ChIP-Seq_K562_Human1.50805086
51* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.50553427
52* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.49910460
53ELF1_20517297_ChIP-Seq_JURKAT_Human1.45613991
54MYC_19030024_ChIP-ChIP_MESCs_Mouse1.43682198
55XRN2_22483619_ChIP-Seq_HELA_Human1.42798312
56CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.41903559
57SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.41007254
58DCP1A_22483619_ChIP-Seq_HELA_Human1.40219990
59ESR1_20079471_ChIP-ChIP_T-47D_Human1.35058623
60TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.32824260
61* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31131998
62SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.30465466
63CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.30275290
64TET1_21451524_ChIP-Seq_MESCs_Mouse1.28991639
65YY1_22570637_ChIP-Seq_MALME-3M_Human1.28583887
66ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.27357012
67* FOXA2_19822575_ChIP-Seq_HepG2_Human1.23563352
68LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.23408076
69CTCF_26484167_Chip-Seq_Bcells_Mouse1.22052598
70* CIITA_25753668_ChIP-Seq_RAJI_Human1.20890122
71CTCF_18555785_ChIP-Seq_MESCs_Mouse1.20564496
72TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.20508373
73* P68_20966046_ChIP-Seq_HELA_Human1.18975987
74PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16556702
75SRY_22984422_ChIP-ChIP_TESTIS_Rat1.15156125
76NELFA_20434984_ChIP-Seq_ESCs_Mouse1.14602385
77CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.12925337
78EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.12507876
79KDM5A_27292631_Chip-Seq_BREAST_Human1.12413693
80IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.11137317
81NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.09994954
82P300_27268052_Chip-Seq_Bcells_Human1.06861737
83FOXP1_21924763_ChIP-Seq_HESCs_Human1.06476932
84SOX2_27498859_Chip-Seq_STOMACH_Mouse1.06081399
85STAT1_20625510_ChIP-Seq_HELA_Human1.04213510
86NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.03856970
87* E2F1_20622854_ChIP-Seq_HELA_Human1.02993322
88ESR2_21235772_ChIP-Seq_MCF-7_Human1.02592492
89BP1_19119308_ChIP-ChIP_Hs578T_Human1.02091981
90* SA1_27219007_Chip-Seq_Bcells_Human1.01369316
91RARB_24833708_ChIP-Seq_LIVER_Mouse1.00929993
92HNF4A_19822575_ChIP-Seq_HepG2_Human1.00771232
93MYC_19079543_ChIP-ChIP_MESCs_Mouse1.00536531
94PHF8_20622854_ChIP-Seq_HELA_Human0.98449370
95ERG_20887958_ChIP-Seq_HPC-7_Mouse0.97754574
96PU.1_20513432_ChIP-Seq_Bcells_Mouse0.96486922
97TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96399422
98BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96313547
99RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.94538492
100SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93829704
101CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.93433631
102SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93066019
103TBX5_21415370_ChIP-Seq_HL-1_Mouse0.92294540
104SA1_27219007_Chip-Seq_ERYTHROID_Human0.92203964
105TTF2_22483619_ChIP-Seq_HELA_Human0.91975086
106* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.91912286
107LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.91591037
108HTT_18923047_ChIP-ChIP_STHdh_Human0.91256555
109SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.91183764
110CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.90992273
111IRF8_22096565_ChIP-ChIP_GC-B_Human0.88758183
112BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.88662175
113CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.87856323
114AUTS2_25519132_ChIP-Seq_293T-REX_Human0.87542496
115EGR1_19032775_ChIP-ChIP_M12_Human0.86389146
116GATA2_21666600_ChIP-Seq_HMVEC_Human0.85230016
117PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.84387458
118GATA4_25053715_ChIP-Seq_YYC3_Human0.84189197
119GATA4_21415370_ChIP-Seq_HL-1_Mouse0.83025668
120STAT3_1855785_ChIP-Seq_MESCs_Mouse0.82755264
121CEBPB_22108803_ChIP-Seq_LS180_Human0.82648728
122NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.81885935
123NRF2_20460467_ChIP-Seq_MEFs_Mouse0.81885935
124TRIM28_21343339_ChIP-Seq_HEK293_Human0.81375390
125GATA1_19941826_ChIP-Seq_K562_Human0.81059966
126* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.80779950
127SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.80606628
128RAD21_21589869_ChIP-Seq_MESCs_Mouse0.79400770
129GATA2_19941826_ChIP-Seq_K562_Human0.75745580
130CDX2_19796622_ChIP-Seq_MESCs_Mouse0.74966723
131RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.74802751
132TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.74354666
133* SRF_21415370_ChIP-Seq_HL-1_Mouse0.74146783
134E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.73979571
135MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.72783735
136P63_26484246_Chip-Seq_KERATINOCYTES_Human0.72348501
137RXRA_24833708_ChIP-Seq_LIVER_Mouse0.70815941
138FOXO3_23340844_ChIP-Seq_DLD1_Human0.68021271
139* LXR_22292898_ChIP-Seq_THP-1_Human0.67831924
140GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.67801072
141PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.67353407
142AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.67183932
143ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.65701132
144ESR1_21235772_ChIP-Seq_MCF-7_Human0.65410184
145NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.65300325
146EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.65018230
147PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.64915274
148RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.63836560
149* BCOR_27268052_Chip-Seq_Bcells_Human0.63237705
150OCT4_20526341_ChIP-Seq_ESCs_Human0.62435318
151ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.62405410
152SOX2_20726797_ChIP-Seq_SW620_Human0.62272616
153GATA1_19941827_ChIP-Seq_MEL_Mouse0.61875614
154TAF2_19829295_ChIP-Seq_ESCs_Human0.61791941
155AR_20517297_ChIP-Seq_VCAP_Human0.61710511
156CSB_26484114_Chip-Seq_FIBROBLAST_Human0.61704798
157SALL4_18804426_ChIP-ChIP_XEN_Mouse0.61060742
158Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.60910702
159* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.60744579
160BCL6_27268052_Chip-Seq_Bcells_Human0.60409576
161SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.60328075
162STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.57980496
163NANOG_20526341_ChIP-Seq_ESCs_Human0.57757183
164ERG_20517297_ChIP-Seq_VCAP_Human0.57214101
165RACK7_27058665_Chip-Seq_MCF-7_Human0.56415331
166SPI1_20517297_ChIP-Seq_HL60_Human0.55252442

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.03633552
2MP0005360_urolithiasis4.83911237
3MP0002837_dystrophic_cardiac_calcinosis4.29747713
4MP0005085_abnormal_gallbladder_physiolo4.08338549
5MP0005365_abnormal_bile_salt3.89967749
6MP0004145_abnormal_muscle_electrophysio3.61164377
7MP0003806_abnormal_nucleotide_metabolis3.46059219
8MP0008875_abnormal_xenobiotic_pharmacok3.29244503
9MP0003646_muscle_fatigue3.19217997
10MP0004130_abnormal_muscle_cell2.68878496
11MP0005670_abnormal_white_adipose2.68152949
12MP0005332_abnormal_amino_acid2.61753669
13MP0010329_abnormal_lipoprotein_level2.59970260
14MP0004084_abnormal_cardiac_muscle2.58704005
15MP0003195_calcinosis2.52722847
16MP0005330_cardiomyopathy2.41881596
17MP0009840_abnormal_foam_cell2.41198827
18MP0003252_abnormal_bile_duct2.39024668
19MP0004215_abnormal_myocardial_fiber2.31622377
20MP0000751_myopathy2.29660942
21MP0006036_abnormal_mitochondrial_physio2.26366093
22MP0004036_abnormal_muscle_relaxation2.20052873
23MP0005666_abnormal_adipose_tissue2.18082233
24MP0003191_abnormal_cellular_cholesterol2.12742922
25MP0002118_abnormal_lipid_homeostasis1.98418628
26MP0002132_abnormal_respiratory_system1.97112513
27MP0000372_irregular_coat_pigmentation1.92883906
28MP0000749_muscle_degeneration1.86668818
29MP0005083_abnormal_biliary_tract1.81148552
30MP0005319_abnormal_enzyme/_coenzyme1.69937114
31MP0008775_abnormal_heart_ventricle1.67115998
32MP0001666_abnormal_nutrient_absorption1.66128548
33MP0005584_abnormal_enzyme/coenzyme_acti1.65125236
34MP0002972_abnormal_cardiac_muscle1.64318798
35MP0005451_abnormal_body_composition1.63249089
36MP0000609_abnormal_liver_physiology1.62430183
37MP0003186_abnormal_redox_activity1.62326154
38MP0009643_abnormal_urine_homeostasis1.57748294
39MP0005075_abnormal_melanosome_morpholog1.56460643
40MP0004087_abnormal_muscle_fiber1.54843312
41MP0005385_cardiovascular_system_phenoty1.53879303
42MP0001544_abnormal_cardiovascular_syste1.53879303
43MP0009333_abnormal_splenocyte_physiolog1.49090513
44MP0004019_abnormal_vitamin_homeostasis1.47096396
45MP0004185_abnormal_adipocyte_glucose1.46821793
46MP0002971_abnormal_brown_adipose1.42778249
47MP0004043_abnormal_pH_regulation1.41596084
48MP0005645_abnormal_hypothalamus_physiol1.41123150
49MP0006138_congestive_heart_failure1.38266965
50MP0005620_abnormal_muscle_contractility1.37797337
51MP0005671_abnormal_response_to1.30978264
52MP0005375_adipose_tissue_phenotype1.30466947
53MP0010630_abnormal_cardiac_muscle1.30434007
54MP0003137_abnormal_impulse_conducting1.26170685
55MP0001764_abnormal_homeostasis1.24810884
56MP0002138_abnormal_hepatobiliary_system1.23730906
57MP0005464_abnormal_platelet_physiology1.21606442
58MP0003221_abnormal_cardiomyocyte_apopto1.21070182
59MP0002269_muscular_atrophy1.18086174
60MP0002148_abnormal_hypersensitivity_rea1.17960666
61MP0005535_abnormal_body_temperature1.16053562
62MP0004484_altered_response_of1.15333170
63MP0002166_altered_tumor_susceptibility1.14839779
64MP0000750_abnormal_muscle_regeneration1.14380282
65MP0003075_altered_response_to1.14141948
66MP0006035_abnormal_mitochondrial_morpho1.13499180
67MP0000343_altered_response_to1.11225142
68MP0008872_abnormal_physiological_respon1.09438900
69MP0010368_abnormal_lymphatic_system1.07026799
70MP0004147_increased_porphyrin_level1.04367017
71MP0002106_abnormal_muscle_physiology1.01151526
72MP0000230_abnormal_systemic_arterial1.00971246
73MP0000747_muscle_weakness1.00883620
74MP0003656_abnormal_erythrocyte_physiolo1.00336828
75MP0002078_abnormal_glucose_homeostasis1.00174699
76MP0005334_abnormal_fat_pad0.99392605
77MP0002653_abnormal_ependyma_morphology0.97776934
78MP0001756_abnormal_urination0.97084919
79MP0005266_abnormal_metabolism0.94750227
80MP0003011_delayed_dark_adaptation0.93505434
81MP0003828_pulmonary_edema0.93270613
82MP0003786_premature_aging0.92247092
83MP0005165_increased_susceptibility_to0.92004041
84MP0005636_abnormal_mineral_homeostasis0.91942322
85MP0005084_abnormal_gallbladder_morpholo0.91913390
86MP0004085_abnormal_heartbeat0.90543661
87MP0003724_increased_susceptibility_to0.88860926
88MP0003950_abnormal_plasma_membrane0.88485334
89MP0009785_altered_susceptibility_to0.88267069
90MP0002822_catalepsy0.87824364
91MP0001873_stomach_inflammation0.85633190
92MP0002332_abnormal_exercise_endurance0.85428419
93MP0009763_increased_sensitivity_to0.84861131
94MP0001661_extended_life_span0.84679264
95MP0003690_abnormal_glial_cell0.84558439
96MP0003718_maternal_effect0.83584365
97MP0001905_abnormal_dopamine_level0.82060453
98MP0000759_abnormal_skeletal_muscle0.81510644
99MP0005369_muscle_phenotype0.80261826
100MP0008438_abnormal_cutaneous_collagen0.79574325
101MP0000598_abnormal_liver_morphology0.77915339
102MP0001727_abnormal_embryo_implantation0.76852916
103MP0005376_homeostasis/metabolism_phenot0.76044092
104MP0009642_abnormal_blood_homeostasis0.75615574
105MP0008469_abnormal_protein_level0.75392411
106MP0005379_endocrine/exocrine_gland_phen0.75189048
107MP0001835_abnormal_antigen_presentation0.74859332
108MP0001881_abnormal_mammary_gland0.73549804
109MP0008058_abnormal_DNA_repair0.73527696
110MP0009115_abnormal_fat_cell0.73370924
111MP0009764_decreased_sensitivity_to0.72974355
112MP0009697_abnormal_copulation0.72150463
113MP0005025_abnormal_response_to0.71768066
114MP0005058_abnormal_lysosome_morphology0.70948506
115MP0001545_abnormal_hematopoietic_system0.69873611
116MP0005397_hematopoietic_system_phenotyp0.69873611
117MP0001853_heart_inflammation0.69825441
118MP0002127_abnormal_cardiovascular_syste0.68381596
119MP0003868_abnormal_feces_composition0.67860387
120MP0005166_decreased_susceptibility_to0.67032314
121MP0002876_abnormal_thyroid_physiology0.66289626
122MP0002136_abnormal_kidney_physiology0.65300059
123MP0002970_abnormal_white_adipose0.61598220
124MP0005647_abnormal_sex_gland0.61327613
125MP0003705_abnormal_hypodermis_morpholog0.60765910
126MP0005448_abnormal_energy_balance0.60652602
127MP0000604_amyloidosis0.60097108
128MP0001765_abnormal_ion_homeostasis0.59736750
129MP0000013_abnormal_adipose_tissue0.58453675
130MP0000003_abnormal_adipose_tissue0.57431132

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of fatty-acid metabolism (HP:0004359)4.90345488
2Hypoglycemic coma (HP:0001325)4.71409831
3Hyperglycinuria (HP:0003108)4.47066773
4Ketosis (HP:0001946)4.33071855
5Hyperammonemia (HP:0001987)4.28971884
6Myoglobinuria (HP:0002913)4.25232506
7Abnormality of dicarboxylic acid metabolism (HP:0010995)4.24326987
8Dicarboxylic aciduria (HP:0003215)4.24326987
9Ketoacidosis (HP:0001993)4.16624517
10Abnormality of aromatic amino acid family metabolism (HP:0004338)4.12366479
11Abnormality of serine family amino acid metabolism (HP:0010894)4.09305096
12Abnormality of glycine metabolism (HP:0010895)4.09305096
13Nemaline bodies (HP:0003798)4.08674928
14Hepatic necrosis (HP:0002605)3.97117595
15Muscle fiber inclusion bodies (HP:0100299)3.95711736
16Xanthomatosis (HP:0000991)3.91542968
17Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.83683438
18Intrahepatic cholestasis (HP:0001406)3.80079041
19Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.78048543
20Generalized aminoaciduria (HP:0002909)3.77257506
21Cerebral edema (HP:0002181)3.68748650
22Sudden death (HP:0001699)3.63949764
23Deep venous thrombosis (HP:0002625)3.63315345
24Hyperlipoproteinemia (HP:0010980)3.60198549
25Decreased activity of mitochondrial respiratory chain (HP:0008972)3.48475610
26Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.48475610
27Ventricular tachycardia (HP:0004756)3.47703273
28Rhabdomyolysis (HP:0003201)3.46917506
29Hyperglycinemia (HP:0002154)3.39954371
30Acute encephalopathy (HP:0006846)3.37622973
31Increased muscle lipid content (HP:0009058)3.30236459
32Exercise-induced myalgia (HP:0003738)3.29173407
33Exercise intolerance (HP:0003546)3.24554588
34Palpitations (HP:0001962)3.13137060
35Hepatocellular necrosis (HP:0001404)3.12638504
36Hypoalphalipoproteinemia (HP:0003233)3.10484542
37Abnormality of monocarboxylic acid metabolism (HP:0010996)3.08915930
38Lethargy (HP:0001254)3.08350197
39Abnormal mitochondria in muscle tissue (HP:0008316)3.02899942
40Metabolic acidosis (HP:0001942)3.00766740
41Calf muscle hypertrophy (HP:0008981)3.00123764
42Prolonged partial thromboplastin time (HP:0003645)2.97944991
43Acute necrotizing encephalopathy (HP:0006965)2.97660029
44Cerebral palsy (HP:0100021)2.94873087
45Proximal tubulopathy (HP:0000114)2.93564903
46Exercise-induced muscle cramps (HP:0003710)2.90670648
47Lipoatrophy (HP:0100578)2.90234343
48Hypobetalipoproteinemia (HP:0003563)2.90130217
49Right ventricular cardiomyopathy (HP:0011663)2.87828284
50Hypolipoproteinemia (HP:0010981)2.87014192
51Increased serum lactate (HP:0002151)2.86714788
52Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.82278096
53Abnormality of aspartate family amino acid metabolism (HP:0010899)2.81589614
54Abnormality of glutamine family amino acid metabolism (HP:0010902)2.81077652
55Nausea (HP:0002018)2.76189868
56Myopathic facies (HP:0002058)2.75974757
57Muscle fiber splitting (HP:0003555)2.75847171
58Muscle hypertrophy of the lower extremities (HP:0008968)2.73039253
59Vomiting (HP:0002013)2.71352385
60Complement deficiency (HP:0004431)2.69372247
61Increased serum pyruvate (HP:0003542)2.68746060
62Abnormality of glycolysis (HP:0004366)2.68746060
63Dilated cardiomyopathy (HP:0001644)2.68264571
64Lactic acidosis (HP:0003128)2.66805222
65Renal Fanconi syndrome (HP:0001994)2.65287113
66Abnormality of serum amino acid levels (HP:0003112)2.64018744
67Atrial fibrillation (HP:0005110)2.63650588
68Increased hepatocellular lipid droplets (HP:0006565)2.63532592
69Mitochondrial inheritance (HP:0001427)2.60023613
70Increased intramyocellular lipid droplets (HP:0012240)2.59148371
71Centrally nucleated skeletal muscle fibers (HP:0003687)2.54969389
72Epidermoid cyst (HP:0200040)2.53953394
73Hyporeflexia of lower limbs (HP:0002600)2.53606731
74Increased CSF lactate (HP:0002490)2.53493312
75Renal cortical cysts (HP:0000803)2.51544263
76Glycosuria (HP:0003076)2.51460385
77Abnormality of urine glucose concentration (HP:0011016)2.51460385
78Type I transferrin isoform profile (HP:0003642)2.50512077
79Progressive macrocephaly (HP:0004481)2.47077236
80EMG: myopathic abnormalities (HP:0003458)2.42932067
81Primary atrial arrhythmia (HP:0001692)2.38084556
82Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.37670802
83Delayed CNS myelination (HP:0002188)2.36884349
84Lipid accumulation in hepatocytes (HP:0006561)2.36450507
85Abnormality of methionine metabolism (HP:0010901)2.33878103
86Joint hemorrhage (HP:0005261)2.33020663
873-Methylglutaconic aciduria (HP:0003535)2.32735416
88Abnormality of purine metabolism (HP:0004352)2.32158616
89Gout (HP:0001997)2.31446004
90Supraventricular tachycardia (HP:0004755)2.30981981
91Testicular atrophy (HP:0000029)2.30230188
92Abnormality of sulfur amino acid metabolism (HP:0004339)2.28904642
93Neck muscle weakness (HP:0000467)2.27962826
94Atrioventricular block (HP:0001678)2.26410013
95Supraventricular arrhythmia (HP:0005115)2.25772151
96Syncope (HP:0001279)2.25519603
97Conjunctival hamartoma (HP:0100780)2.25285474
98Methylmalonic aciduria (HP:0012120)2.23380982
99Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.22680337
100CNS demyelination (HP:0007305)2.22618989
101Abnormality of the calf musculature (HP:0001430)2.21462537
102Asymmetric septal hypertrophy (HP:0001670)2.20398751
103Emotional lability (HP:0000712)2.19239076
104Respiratory failure (HP:0002878)2.19199834
105Hyperbilirubinemia (HP:0002904)2.16623246
106Petechiae (HP:0000967)2.15216251
107Hyperinsulinemic hypoglycemia (HP:0000825)2.13823538
108Abnormality of the common coagulation pathway (HP:0010990)2.13293085
109Skin nodule (HP:0200036)2.11611756
110Cholelithiasis (HP:0001081)2.11350645
111Cerebral hemorrhage (HP:0001342)2.09020354
112Heart block (HP:0012722)2.07156444
113Abnormal gallbladder physiology (HP:0012438)2.06220063
114Cholecystitis (HP:0001082)2.06220063
115Abnormal gallbladder morphology (HP:0012437)2.06025931
116Increased purine levels (HP:0004368)2.05289885
117Hyperuricemia (HP:0002149)2.05289885
118Microvesicular hepatic steatosis (HP:0001414)2.05001057
119Hypercholesterolemia (HP:0003124)2.04625518
120Fat malabsorption (HP:0002630)2.04585055
121Reduced antithrombin III activity (HP:0001976)2.03830636
122Opisthotonus (HP:0002179)2.03461198
123Type 1 muscle fiber predominance (HP:0003803)2.03353124
124Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.01228164
125Abnormal protein N-linked glycosylation (HP:0012347)2.01228164
126Abnormal protein glycosylation (HP:0012346)2.01228164
127Abnormal glycosylation (HP:0012345)2.01228164
128Abnormality of nucleobase metabolism (HP:0010932)2.00959929
129Distal lower limb muscle weakness (HP:0009053)2.00885228
130Progressive muscle weakness (HP:0003323)2.00063251
131Ragged-red muscle fibers (HP:0003200)1.97478002
132Abnormality of the heme biosynthetic pathway (HP:0010472)1.96204996
133Muscle stiffness (HP:0003552)1.95606372
134Abnormal pupillary function (HP:0007686)1.95338641
135Abnormality of the intrinsic pathway (HP:0010989)1.94581889
136Increased connective tissue (HP:0009025)1.93409005
137Optic disc pallor (HP:0000543)1.89812492
138Distal arthrogryposis (HP:0005684)1.86661726
139Muscle fiber atrophy (HP:0100295)1.86587031
140Type 2 muscle fiber atrophy (HP:0003554)1.86215145
141Rimmed vacuoles (HP:0003805)1.85426709
142Aplastic anemia (HP:0001915)1.85309750
143Agammaglobulinemia (HP:0004432)1.84831751
144Paralysis (HP:0003470)1.84302783
145Systemic lupus erythematosus (HP:0002725)1.81756687
146Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.81500454
147Hyperalaninemia (HP:0003348)1.81500454

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.18427349
2VRK25.68064193
3TTN3.70923230
4TESK23.52137531
5PDK43.47751563
6PDK33.47751563
7MYLK3.17469604
8LMTK22.85560567
9TRIB32.66367990
10TESK12.50039210
11TIE12.41232375
12PHKG22.38038076
13PHKG12.38038076
14PDK22.31298795
15PKN22.26915597
16OBSCN2.26473827
17PIM22.19275474
18WNK42.18373831
19PINK12.10386653
20TXK2.07949946
21SIK11.98208266
22ERN11.88805271
23FGFR41.85208653
24STK391.83104770
25SCYL21.82204150
26NUAK11.80753417
27INSRR1.77211507
28PIK3CA1.76806231
29LIMK11.72811276
30MAP4K21.68328492
31VRK11.65188543
32EPHB11.64426617
33ARAF1.59289487
34DAPK11.59197752
35NME11.48328591
36KDR1.46306652
37STK161.46164605
38MUSK1.37288614
39FLT31.36225146
40MAP3K111.35640774
41MAP3K121.31508838
42OXSR11.29771134
43TNK21.26825551
44GRK71.24539582
45PRKAA21.22888724
46NME21.15868402
47MST1R1.15483258
48GRK11.12970540
49TGFBR21.02470519
50EIF2AK11.01860199
51PRKD11.00507625
52MAP2K20.97217578
53MAP2K30.96230256
54NEK90.94331266
55MAP3K70.91705171
56STK240.90639913
57PAK30.90510248
58PIK3CG0.89847367
59DMPK0.88945230
60PKN10.88529769
61CAMK2D0.87474655
62CAMK1D0.87398415
63SMG10.86302575
64BUB10.85965032
65MAPK120.83753296
66TYK20.83609480
67MAP3K30.83444632
68CSNK1G30.82772512
69STK38L0.80725869
70MAPK110.79017128
71PRKAA10.78400800
72NEK10.77688196
73ILK0.76333677
74IKBKB0.75589540
75TBK10.75557249
76ZAK0.75321692
77PDPK10.75068822
78EPHA20.74482438
79PRKD30.74252843
80MET0.74239978
81ABL20.73516893
82PBK0.71566424
83TAOK30.67061944
84IRAK30.65117952
85PRKCI0.63500000
86WNK30.63483145
87CAMK2G0.62211752
88CCNB10.61157488
89TRPM70.60883798
90JAK10.60464009
91PRKACG0.60364400
92FER0.60028488
93MAPKAPK50.57043187
94JAK20.56841810
95CSNK1G10.55062968
96SYK0.51156032
97GRK50.50419612
98PDK10.50385711
99LRRK20.50129681
100RPS6KA50.49831965
101RIPK10.49808949
102CSF1R0.49066783
103STK40.48895530
104TAOK20.48761483
105MAPKAPK30.48189184
106PTK60.47726139
107EIF2AK30.47442080
108MAPK40.47234884
109CSNK1A1L0.46214346
110AURKA0.45343887
111TAF10.45147023
112CAMK40.44676360
113PRKCQ0.44515301
114CSNK2A20.44305260
115EPHA30.43664312
116FGFR20.43523725
117TLK10.40888510
118GRK60.40805459
119ROCK10.40737939
120CSNK1G20.40152635
121CSNK2A10.40082974
122PRKACA0.39499671
123PRKG20.38986276
124RPS6KB20.38790345
125RPS6KA60.38128615
126DAPK30.37905997
127ERBB40.37904171
128IKBKE0.37651489
129RPS6KC10.37561665
130RPS6KL10.37561665
131GSK3A0.36585453
132FES0.35840199
133PRKACB0.35692423
134ITK0.34606931
135MAP2K60.34240982
136AKT20.33981601
137DYRK20.33712107
138ZAP700.33546809
139MAP4K10.32492393
140WNK10.32443444
141SGK4940.30987175
142SGK2230.30987175
143MAPK150.30945714
144ADRBK20.28878525
145MST40.28801708
146CSK0.28761016
147MAPKAPK20.28538501
148ATR0.28109668
149PRKCH0.27792405
150PRKCE0.27341538
151CAMK2A0.26441903
152KIT0.25846320
153MAP2K10.25178978
154PAK10.25163878
155SGK30.24077019
156ROCK20.23741498

Predicted pathways (KEGG)

RankGene SetZ-score
1Propanoate metabolism_Homo sapiens_hsa006403.59821592
2Fatty acid degradation_Homo sapiens_hsa000713.56560220
3Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.45037834
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.35477171
5Proteasome_Homo sapiens_hsa030503.20694128
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.08101256
7Fatty acid metabolism_Homo sapiens_hsa012122.85978922
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.77749795
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.77071333
10Primary bile acid biosynthesis_Homo sapiens_hsa001202.70485231
11Butanoate metabolism_Homo sapiens_hsa006502.51019452
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.48697963
13Fatty acid elongation_Homo sapiens_hsa000622.39764388
14Tryptophan metabolism_Homo sapiens_hsa003802.34296188
15PPAR signaling pathway_Homo sapiens_hsa033202.27310707
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.23352780
17Pyruvate metabolism_Homo sapiens_hsa006202.17636671
18Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.15940099
19* Peroxisome_Homo sapiens_hsa041462.06820277
20Carbon metabolism_Homo sapiens_hsa012002.06136893
21Arginine biosynthesis_Homo sapiens_hsa002202.03281206
22Nitrogen metabolism_Homo sapiens_hsa009101.96042057
23beta-Alanine metabolism_Homo sapiens_hsa004101.90776404
24Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.80879137
25Pentose and glucuronate interconversions_Homo sapiens_hsa000401.64187133
26Oxidative phosphorylation_Homo sapiens_hsa001901.63035799
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.58604546
28Ribosome_Homo sapiens_hsa030101.52553615
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.52275885
30Parkinsons disease_Homo sapiens_hsa050121.49913690
31Complement and coagulation cascades_Homo sapiens_hsa046101.47182496
32Sulfur metabolism_Homo sapiens_hsa009201.39745399
33Histidine metabolism_Homo sapiens_hsa003401.35489369
34Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.34304966
35Chemical carcinogenesis_Homo sapiens_hsa052041.32432003
36Phenylalanine metabolism_Homo sapiens_hsa003601.31729289
37Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.31200560
38Starch and sucrose metabolism_Homo sapiens_hsa005001.24525677
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.24398331
40Biosynthesis of amino acids_Homo sapiens_hsa012301.23792671
41Primary immunodeficiency_Homo sapiens_hsa053401.23787695
42Caffeine metabolism_Homo sapiens_hsa002321.19922403
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.19258730
44Tyrosine metabolism_Homo sapiens_hsa003501.16882879
45RNA polymerase_Homo sapiens_hsa030201.12858436
46Steroid hormone biosynthesis_Homo sapiens_hsa001401.07215981
47Base excision repair_Homo sapiens_hsa034101.06411545
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.05207932
49Arginine and proline metabolism_Homo sapiens_hsa003301.05030328
50Retinol metabolism_Homo sapiens_hsa008301.04836707
51Alzheimers disease_Homo sapiens_hsa050101.04577813
52Cardiac muscle contraction_Homo sapiens_hsa042601.01800480
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.00471042
54One carbon pool by folate_Homo sapiens_hsa006700.99903329
55Fat digestion and absorption_Homo sapiens_hsa049750.98458531
56Fatty acid biosynthesis_Homo sapiens_hsa000610.95887909
57Bile secretion_Homo sapiens_hsa049760.95410176
58Drug metabolism - other enzymes_Homo sapiens_hsa009830.92387612
59Staphylococcus aureus infection_Homo sapiens_hsa051500.91993643
60Cysteine and methionine metabolism_Homo sapiens_hsa002700.90724605
61DNA replication_Homo sapiens_hsa030300.88973927
62Folate biosynthesis_Homo sapiens_hsa007900.88364032
63Glycerolipid metabolism_Homo sapiens_hsa005610.88336289
64Selenocompound metabolism_Homo sapiens_hsa004500.86801187
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86267915
66Pyrimidine metabolism_Homo sapiens_hsa002400.86126366
67Glutathione metabolism_Homo sapiens_hsa004800.82651047
68ABC transporters_Homo sapiens_hsa020100.81220916
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78670407
70Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.77209683
71Huntingtons disease_Homo sapiens_hsa050160.76931993
72Lysine degradation_Homo sapiens_hsa003100.73825739
73Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.71676830
74Purine metabolism_Homo sapiens_hsa002300.69740855
75Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.68876861
76Mismatch repair_Homo sapiens_hsa034300.66989227
77Steroid biosynthesis_Homo sapiens_hsa001000.65390845
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.65340878
79Pentose phosphate pathway_Homo sapiens_hsa000300.64499513
80Metabolic pathways_Homo sapiens_hsa011000.63498310
81Sulfur relay system_Homo sapiens_hsa041220.59553636
82Cyanoamino acid metabolism_Homo sapiens_hsa004600.58567008
83Asthma_Homo sapiens_hsa053100.58077355
84Vitamin digestion and absorption_Homo sapiens_hsa049770.54714994
85Autoimmune thyroid disease_Homo sapiens_hsa053200.53370015
86Antigen processing and presentation_Homo sapiens_hsa046120.49587712
87Homologous recombination_Homo sapiens_hsa034400.49118654
88Insulin resistance_Homo sapiens_hsa049310.49083931
89Allograft rejection_Homo sapiens_hsa053300.48702962
90Vitamin B6 metabolism_Homo sapiens_hsa007500.48236764
91Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.48018204
92Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47546584
93Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.46977272
94Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.46932685
95Dilated cardiomyopathy_Homo sapiens_hsa054140.46317185
96Graft-versus-host disease_Homo sapiens_hsa053320.44552177
97Intestinal immune network for IgA production_Homo sapiens_hsa046720.43407577
98Galactose metabolism_Homo sapiens_hsa000520.41131796
99Fructose and mannose metabolism_Homo sapiens_hsa000510.40873113
100Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.38654920
101Type I diabetes mellitus_Homo sapiens_hsa049400.38606163
102Nucleotide excision repair_Homo sapiens_hsa034200.37695624
103alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37484848
104SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32165269
105AMPK signaling pathway_Homo sapiens_hsa041520.31352156
106Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.30865171
107Collecting duct acid secretion_Homo sapiens_hsa049660.28311788
108Glucagon signaling pathway_Homo sapiens_hsa049220.27249937
109Glycosaminoglycan degradation_Homo sapiens_hsa005310.26983990
110Maturity onset diabetes of the young_Homo sapiens_hsa049500.26297500
111Linoleic acid metabolism_Homo sapiens_hsa005910.24733227
112Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.20942047
113Arachidonic acid metabolism_Homo sapiens_hsa005900.16769584
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.14176159
115Insulin signaling pathway_Homo sapiens_hsa049100.12580757
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.11393060
117Viral myocarditis_Homo sapiens_hsa054160.01747941
118Regulation of autophagy_Homo sapiens_hsa04140-0.1551678
119Protein export_Homo sapiens_hsa03060-0.1511705
120Ether lipid metabolism_Homo sapiens_hsa00565-0.1364428
121Protein digestion and absorption_Homo sapiens_hsa04974-0.1347483
122Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1240169
123Lysosome_Homo sapiens_hsa04142-0.1196352
124Prion diseases_Homo sapiens_hsa05020-0.1068467
125Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.0825667
126Other glycan degradation_Homo sapiens_hsa00511-0.0582039
127Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0275237

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