ECHDC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)7.08620830
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.89579655
3L-phenylalanine catabolic process (GO:0006559)6.89579655
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.84952910
5L-phenylalanine metabolic process (GO:0006558)6.84952910
6epoxygenase P450 pathway (GO:0019373)6.31516810
7aromatic amino acid family catabolic process (GO:0009074)6.24632205
8tryptophan catabolic process (GO:0006569)5.80059216
9indole-containing compound catabolic process (GO:0042436)5.80059216
10indolalkylamine catabolic process (GO:0046218)5.80059216
11serine family amino acid catabolic process (GO:0009071)5.77366600
12cysteine metabolic process (GO:0006534)5.74592571
13glyoxylate metabolic process (GO:0046487)5.61749295
14kynurenine metabolic process (GO:0070189)5.60456623
15tryptophan metabolic process (GO:0006568)5.46840202
16sulfur amino acid catabolic process (GO:0000098)5.43415938
17omega-hydroxylase P450 pathway (GO:0097267)5.33133754
18triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.32919621
19glycine metabolic process (GO:0006544)5.30208798
20bile acid biosynthetic process (GO:0006699)5.14525888
21homocysteine metabolic process (GO:0050667)5.03754804
22serine family amino acid metabolic process (GO:0009069)4.92549508
23aromatic amino acid family metabolic process (GO:0009072)4.88388033
24serine family amino acid biosynthetic process (GO:0009070)4.82513270
25amino-acid betaine metabolic process (GO:0006577)4.81374305
26alpha-linolenic acid metabolic process (GO:0036109)4.76974535
27lysine metabolic process (GO:0006553)4.75315089
28lysine catabolic process (GO:0006554)4.75315089
29urea cycle (GO:0000050)4.74880009
30urea metabolic process (GO:0019627)4.74880009
31drug metabolic process (GO:0017144)4.72920550
32regulation of protein activation cascade (GO:2000257)4.66098883
33alpha-amino acid catabolic process (GO:1901606)4.63167817
34ethanol metabolic process (GO:0006067)4.52496982
35negative regulation of fibrinolysis (GO:0051918)4.50933524
36fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.49221168
37high-density lipoprotein particle remodeling (GO:0034375)4.47163101
38oxidative demethylation (GO:0070989)4.47093976
39bile acid metabolic process (GO:0008206)4.44828211
40complement activation, alternative pathway (GO:0006957)4.44055984
41nitrogen cycle metabolic process (GO:0071941)4.41396967
42peptidyl-glutamic acid carboxylation (GO:0017187)4.40727836
43protein carboxylation (GO:0018214)4.40727836
44regulation of complement activation (GO:0030449)4.38516669
45cellular amino acid catabolic process (GO:0009063)4.37225358
46regulation of fibrinolysis (GO:0051917)4.35483357
47cellular modified amino acid catabolic process (GO:0042219)4.21307094
48acylglycerol homeostasis (GO:0055090)4.09890564
49triglyceride homeostasis (GO:0070328)4.09890564
50regulation of triglyceride catabolic process (GO:0010896)4.08967812
51tyrosine metabolic process (GO:0006570)4.08616441
52amine catabolic process (GO:0009310)4.04925088
53cellular biogenic amine catabolic process (GO:0042402)4.04925088
54coenzyme catabolic process (GO:0009109)4.04805427
55indolalkylamine metabolic process (GO:0006586)4.04688499
56negative regulation of cholesterol transport (GO:0032375)4.03434971
57negative regulation of sterol transport (GO:0032372)4.03434971
58regulation of cholesterol esterification (GO:0010872)4.00517442
59complement activation, classical pathway (GO:0006958)3.99981398
60folic acid metabolic process (GO:0046655)3.97365912
61urate metabolic process (GO:0046415)3.97256402
62reverse cholesterol transport (GO:0043691)3.95684011
63protein activation cascade (GO:0072376)3.94737044
64glutamate metabolic process (GO:0006536)3.93395344
65negative regulation of protein activation cascade (GO:2000258)3.89356735
66blood coagulation, intrinsic pathway (GO:0007597)3.87816823
67L-serine metabolic process (GO:0006563)3.85384870
68imidazole-containing compound metabolic process (GO:0052803)3.85135112
69complement activation (GO:0006956)3.84875531
70carboxylic acid catabolic process (GO:0046395)3.81115207
71organic acid catabolic process (GO:0016054)3.81115207
72cellular ketone body metabolic process (GO:0046950)3.80689222
73plasma lipoprotein particle remodeling (GO:0034369)3.80366726
74protein-lipid complex remodeling (GO:0034368)3.80366726
75macromolecular complex remodeling (GO:0034367)3.80366726
76fibrinolysis (GO:0042730)3.79091522
77uronic acid metabolic process (GO:0006063)3.78893316
78glucuronate metabolic process (GO:0019585)3.78893316
79branched-chain amino acid catabolic process (GO:0009083)3.76114010
80valine metabolic process (GO:0006573)3.75412653
81bile acid and bile salt transport (GO:0015721)3.74792464
82regulation of cholesterol homeostasis (GO:2000188)3.74480670
83acetyl-CoA metabolic process (GO:0006084)3.72736667
842-oxoglutarate metabolic process (GO:0006103)3.71510519
85fructose metabolic process (GO:0006000)3.67605947
86benzene-containing compound metabolic process (GO:0042537)3.67463741
87regulation of bile acid biosynthetic process (GO:0070857)3.66866434
88drug catabolic process (GO:0042737)3.65673828
89heme transport (GO:0015886)3.64775487
90aspartate family amino acid catabolic process (GO:0009068)3.63193025
91phenylpropanoid metabolic process (GO:0009698)3.60932847
92flavonoid metabolic process (GO:0009812)3.60421301
93ethanol oxidation (GO:0006069)3.59540635
94alkaloid metabolic process (GO:0009820)3.58649926
95regulation of plasminogen activation (GO:0010755)3.57803610
96phospholipid efflux (GO:0033700)3.55123207
97S-adenosylmethionine metabolic process (GO:0046500)3.54285084
98arginine metabolic process (GO:0006525)3.52132586
99plasma lipoprotein particle clearance (GO:0034381)3.50756600
100regulation of humoral immune response (GO:0002920)3.49530975
101carnitine metabolic process (GO:0009437)3.48243534
102cellular glucuronidation (GO:0052695)3.48081095
103drug transmembrane transport (GO:0006855)3.47482152
104short-chain fatty acid metabolic process (GO:0046459)3.46703424
105positive regulation of lipid catabolic process (GO:0050996)3.45976106
106negative regulation of complement activation (GO:0045916)3.45868638
107branched-chain amino acid metabolic process (GO:0009081)3.45251211
108fatty acid beta-oxidation (GO:0006635)3.45109496
109acute-phase response (GO:0006953)3.44292751
110negative regulation of fatty acid biosynthetic process (GO:0045717)3.43986531
111sulfur amino acid metabolic process (GO:0000096)3.42211634
112fatty acid oxidation (GO:0019395)3.39784431
113intestinal cholesterol absorption (GO:0030299)3.39594382
114positive regulation of triglyceride lipase activity (GO:0061365)3.38188387
115positive regulation of lipoprotein lipase activity (GO:0051006)3.38188387
116cholesterol homeostasis (GO:0042632)3.38029944
117biotin metabolic process (GO:0006768)3.36925444
118cholesterol efflux (GO:0033344)3.33644633
119sterol homeostasis (GO:0055092)3.33536084
120lipid oxidation (GO:0034440)3.33165844
121dicarboxylic acid biosynthetic process (GO:0043650)3.33121915
122pantothenate metabolic process (GO:0015939)3.32837019
123monocarboxylic acid catabolic process (GO:0072329)3.29561271
124fatty acid catabolic process (GO:0009062)3.29394215
125negative regulation of lipase activity (GO:0060192)3.27590569
126negative regulation of hemostasis (GO:1900047)3.20448731
127negative regulation of blood coagulation (GO:0030195)3.20448731
128plasma lipoprotein particle organization (GO:0071827)3.05481002
129ketone body metabolic process (GO:1902224)3.02150172
130negative regulation of humoral immune response (GO:0002921)2.95671869
131fatty acid transmembrane transport (GO:1902001)2.95599813
132positive regulation of triglyceride metabolic process (GO:0090208)2.92587974
133opsonization (GO:0008228)2.91882911
134fat-soluble vitamin biosynthetic process (GO:0042362)2.91306363
135quaternary ammonium group transport (GO:0015697)2.90483730
136protein-lipid complex subunit organization (GO:0071825)2.89727401
137regulation of triglyceride metabolic process (GO:0090207)2.89417311
138xenobiotic metabolic process (GO:0006805)2.88048413
139negative regulation of coagulation (GO:0050819)2.85876584
140lipoprotein metabolic process (GO:0042157)2.85787088
141very-low-density lipoprotein particle assembly (GO:0034379)2.85322069
142cytolysis (GO:0019835)2.79591160
143regulation of apoptotic cell clearance (GO:2000425)2.77770314
144negative regulation of wound healing (GO:0061045)2.76835110
145primary alcohol metabolic process (GO:0034308)2.76732290
146primary alcohol catabolic process (GO:0034310)2.75684064
147response to mercury ion (GO:0046689)2.74654661
148positive regulation of fatty acid beta-oxidation (GO:0032000)2.71301069
149phospholipid homeostasis (GO:0055091)2.69854857
150positive regulation of fatty acid biosynthetic process (GO:0045723)2.69809568

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.42992342
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.64637619
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.92065476
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.13261292
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.93920060
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.65003954
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.38701838
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.26449376
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.51961142
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.02820484
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.60199325
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.17809044
13HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.08536417
14ESR1_20079471_ChIP-ChIP_T-47D_Human2.07930419
15DROSHA_22980978_ChIP-Seq_HELA_Human2.05245211
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.02693598
17STAT3_1855785_ChIP-Seq_MESCs_Mouse1.82128445
18ZNF263_19887448_ChIP-Seq_K562_Human1.80457618
19POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.73660797
20TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.69242295
21BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.67291118
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.67055616
23TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.63589230
24MYC_18555785_ChIP-Seq_MESCs_Mouse1.63273624
25* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.62881413
26MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.58906741
27KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.52873962
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.49658966
29CLOCK_20551151_ChIP-Seq_293T_Human1.47866970
30IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.46805614
31CREB1_15753290_ChIP-ChIP_HEK293T_Human1.46204626
32ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.44089066
33LXR_22292898_ChIP-Seq_THP-1_Human1.42494492
34MYC_18358816_ChIP-ChIP_MESCs_Mouse1.41455789
35PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.39870512
36PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.38440329
37STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.38193787
38NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.38023650
39* CTCF_27219007_Chip-Seq_Bcells_Human1.33857545
40ETS1_20019798_ChIP-Seq_JURKAT_Human1.33199634
41AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.32237526
42NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.31900236
43AR_21909140_ChIP-Seq_LNCAP_Human1.26930892
44NANOG_18555785_ChIP-Seq_MESCs_Mouse1.25998667
45RXRA_24833708_ChIP-Seq_LIVER_Mouse1.25511284
46TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.24283043
47* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.22535023
48TCF3_18692474_ChIP-Seq_MEFs_Mouse1.21113683
49* HNF4A_19822575_ChIP-Seq_HepG2_Human1.21008233
50TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.20672311
51* SMC4_20622854_ChIP-Seq_HELA_Human1.17957375
52ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.17377506
53SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.15988665
54CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.14992236
55MYC_19030024_ChIP-ChIP_MESCs_Mouse1.14267836
56ESR1_15608294_ChIP-ChIP_MCF-7_Human1.14034888
57EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13983557
58KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.13377216
59KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.13377216
60KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.13377216
61RARG_19884340_ChIP-ChIP_MEFs_Mouse1.13202331
62P68_20966046_ChIP-Seq_HELA_Human1.11387410
63NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.10419804
64SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.09908999
65FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07930045
66GATA1_22025678_ChIP-Seq_K562_Human1.07659985
67MYC_19079543_ChIP-ChIP_MESCs_Mouse1.07187040
68CDX2_20551321_ChIP-Seq_CACO-2_Human1.07060201
69RUNX1_27514584_Chip-Seq_MCF-7_Human1.06864471
70GABP_17652178_ChIP-ChIP_JURKAT_Human1.06118328
71* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.05395780
72SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.04293603
73PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.04182015
74SOX2_27498859_Chip-Seq_STOMACH_Mouse1.03281787
75SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.01307115
76OCT4_18692474_ChIP-Seq_MEFs_Mouse0.99877589
77FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.99761185
78TP63_22573176_ChIP-Seq_HFKS_Human0.99644673
79ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99282772
80BCOR_27268052_Chip-Seq_Bcells_Human0.99124154
81RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.98207911
82GATA2_21666600_ChIP-Seq_HMVEC_Human0.98169266
83P63_26484246_Chip-Seq_KERATINOCYTES_Human0.97920675
84RARA_24833708_ChIP-Seq_LIVER_Mouse0.97758911
85BCL6_27268052_Chip-Seq_Bcells_Human0.96761391
86CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.96585162
87EST1_17652178_ChIP-ChIP_JURKAT_Human0.95853707
88FOXA2_19822575_ChIP-Seq_HepG2_Human0.95807430
89GATA4_25053715_ChIP-Seq_YYC3_Human0.95529799
90E2F1_20622854_ChIP-Seq_HELA_Human0.95529630
91* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.94606605
92CREB1_26743006_Chip-Seq_LNCaP_Human0.93522550
93ERA_21632823_ChIP-Seq_H3396_Human0.92807929
94ESR2_21235772_ChIP-Seq_MCF-7_Human0.92699033
95AHR_22903824_ChIP-Seq_MCF-7_Human0.92576417
96OCT4_20526341_ChIP-Seq_ESCs_Human0.91118772
97* SA1_27219007_Chip-Seq_Bcells_Human0.90999882
98POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.90587510
99CDX2_19796622_ChIP-Seq_MESCs_Mouse0.90388024
100DNAJC2_21179169_ChIP-ChIP_NT2_Human0.89901743
101KDM2B_26808549_Chip-Seq_SUP-B15_Human0.89682308
102NELFA_20434984_ChIP-Seq_ESCs_Mouse0.89288722
103* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.89199612
104SRF_21415370_ChIP-Seq_HL-1_Mouse0.88888641
105* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88592056
106FOXO3_23340844_ChIP-Seq_DLD1_Human0.88396658
107SALL4_18804426_ChIP-ChIP_XEN_Mouse0.88126778
108GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.87548486
109STAT6_21828071_ChIP-Seq_BEAS2B_Human0.86716577
110P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.86257511
111RAD21_21589869_ChIP-Seq_MESCs_Mouse0.86218755
112ESR1_21235772_ChIP-Seq_MCF-7_Human0.85724925
113ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.85638594
114PIAS1_25552417_ChIP-Seq_VCAP_Human0.85601386
115STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.85388675
116* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84912912
117DCP1A_22483619_ChIP-Seq_HELA_Human0.84823689
118HTT_18923047_ChIP-ChIP_STHdh_Human0.84785227
119* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.84666518
120PHF8_20622854_ChIP-Seq_HELA_Human0.84288497
121EZH2_27294783_Chip-Seq_ESCs_Mouse0.84084245
122RARB_24833708_ChIP-Seq_LIVER_Mouse0.83935246
123* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.83747701
124BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.83604914
125TRIM28_21343339_ChIP-Seq_HEK293_Human0.82921179
126CEBPB_22108803_ChIP-Seq_LS180_Human0.82798569
127ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.82738677
128GATA1_19941827_ChIP-Seq_MEL_Mouse0.82656899
129TCF3_18692474_ChIP-Seq_MESCs_Mouse0.82551554
130FOXA1_25552417_ChIP-Seq_VCAP_Human0.82431534
131CTCF_20526341_ChIP-Seq_ESCs_Human0.82334085
132ERG_21242973_ChIP-ChIP_JURKAT_Human0.82272698
133GABP_19822575_ChIP-Seq_HepG2_Human0.82163553
134TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.81345831
135NFIB_24661679_ChIP-Seq_LUNG_Mouse0.80786325
136YY1_21170310_ChIP-Seq_MESCs_Mouse0.80761753
137NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.80730474
138NANOG_18692474_ChIP-Seq_MEFs_Mouse0.80114393
139ZNF217_24962896_ChIP-Seq_MCF-7_Human0.79536650
140MYC_27129775_Chip-Seq_CORNEA_Mouse0.78232701
141GATA1_19941826_ChIP-Seq_K562_Human0.78161682
142SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.77968396
143CTNNB1_20460455_ChIP-Seq_HCT116_Human0.77777275
144TET1_21451524_ChIP-Seq_MESCs_Mouse0.77699905
145KLF4_18555785_ChIP-Seq_MESCs_Mouse0.77580764
146* SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.77453942
147TBX20_22328084_ChIP-Seq_HEART_Mouse0.77035848
148TBX20_22080862_ChIP-Seq_HEART_Mouse0.77035848
149POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.76597359
150MYCN_18555785_ChIP-Seq_MESCs_Mouse0.76155012
151BCAT_22108803_ChIP-Seq_LS180_Human0.75558065
152FOXH1_21741376_ChIP-Seq_ESCs_Human0.75484208
153E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.75145903
154SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74756844
155LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.74654997
156P300_27268052_Chip-Seq_Bcells_Human0.74550758
157OCT4_19829295_ChIP-Seq_ESCs_Human0.74529324
158POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.74163301
159KDM5A_27292631_Chip-Seq_BREAST_Human0.73680208
160* POU5F1_16518401_ChIP-PET_MESCs_Mouse0.73557680
161* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.73215259
162BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.72272935
163ATF3_27146783_Chip-Seq_COLON_Human0.71704067
164GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.70958897
165* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.70799578
166GATA6_25053715_ChIP-Seq_YYC3_Human0.67947372
167* NANOG_16518401_ChIP-PET_MESCs_Mouse0.66963295
168XRN2_22483619_ChIP-Seq_HELA_Human0.66868885
169* RACK7_27058665_Chip-Seq_MCF-7_Human0.65417473
170THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.65093901
171TP63_17297297_ChIP-ChIP_HaCaT_Human0.64707229
172PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.63980819
173PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.62534217
174CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.61791670

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.40554100
2MP0005360_urolithiasis6.64084853
3MP0005085_abnormal_gallbladder_physiolo5.86939773
4MP0005365_abnormal_bile_salt5.84146839
5MP0003806_abnormal_nucleotide_metabolis4.65919664
6MP0008875_abnormal_xenobiotic_pharmacok4.44762511
7MP0009840_abnormal_foam_cell3.77729606
8MP0003252_abnormal_bile_duct3.33283243
9MP0005332_abnormal_amino_acid3.22418329
10MP0010329_abnormal_lipoprotein_level3.19747933
11MP0003195_calcinosis3.17937698
12MP0001666_abnormal_nutrient_absorption2.81415536
13MP0004019_abnormal_vitamin_homeostasis2.78090545
14MP0005083_abnormal_biliary_tract2.76876556
15MP0003191_abnormal_cellular_cholesterol2.05674199
16MP0000609_abnormal_liver_physiology2.02333680
17MP0002118_abnormal_lipid_homeostasis2.00367623
18MP0005319_abnormal_enzyme/_coenzyme1.88878389
19MP0002138_abnormal_hepatobiliary_system1.82791118
20MP0001764_abnormal_homeostasis1.76602926
21MP0003879_abnormal_hair_cell1.73065622
22MP0005451_abnormal_body_composition1.67813760
23MP0009643_abnormal_urine_homeostasis1.62563344
24MP0003868_abnormal_feces_composition1.60379692
25MP0003186_abnormal_redox_activity1.59320833
26MP0003646_muscle_fatigue1.55355886
27MP0003718_maternal_effect1.39822647
28MP0003705_abnormal_hypodermis_morpholog1.37045557
29MP0001986_abnormal_taste_sensitivity1.32033887
30MP0005670_abnormal_white_adipose1.29086857
31MP0005584_abnormal_enzyme/coenzyme_acti1.27716352
32MP0000751_myopathy1.24078391
33MP0003045_fibrosis1.21772089
34MP0006036_abnormal_mitochondrial_physio1.21141624
35MP0001756_abnormal_urination1.20383976
36MP0002254_reproductive_system_inflammat1.17324701
37MP0000598_abnormal_liver_morphology1.15058058
38MP0003011_delayed_dark_adaptation1.13986318
39MP0002933_joint_inflammation1.13395289
40MP0003878_abnormal_ear_physiology1.11433350
41MP0005377_hearing/vestibular/ear_phenot1.11433350
42MP0005409_darkened_coat_color1.11371505
43MP0004036_abnormal_muscle_relaxation1.09982285
44MP0005220_abnormal_exocrine_pancreas1.08853175
45MP0009697_abnormal_copulation1.06305495
46MP0001661_extended_life_span1.06275548
47MP0005636_abnormal_mineral_homeostasis1.05836392
48MP0005647_abnormal_sex_gland1.04153461
49MP0009780_abnormal_chondrocyte_physiolo1.02362139
50MP0003693_abnormal_embryo_hatching1.01830251
51MP0006035_abnormal_mitochondrial_morpho1.01365990
52MP0006138_congestive_heart_failure1.01044069
53MP0004145_abnormal_muscle_electrophysio0.96668924
54MP0005375_adipose_tissue_phenotype0.95544480
55MP0004264_abnormal_extraembryonic_tissu0.95264768
56MP0008872_abnormal_physiological_respon0.95142410
57MP0005395_other_phenotype0.94786798
58MP0001501_abnormal_sleep_pattern0.94539883
59MP0002249_abnormal_larynx_morphology0.90774610
60MP0001958_emphysema0.90426892
61MP0001873_stomach_inflammation0.89401061
62MP0000013_abnormal_adipose_tissue0.89331979
63MP0004084_abnormal_cardiac_muscle0.86440784
64MP0000249_abnormal_blood_vessel0.86295822
65MP0005084_abnormal_gallbladder_morpholo0.86160288
66MP0001502_abnormal_circadian_rhythm0.82320367
67MP0005167_abnormal_blood-brain_barrier0.80739903
68MP0004043_abnormal_pH_regulation0.79884862
69MP0002876_abnormal_thyroid_physiology0.78737739
70MP0005266_abnormal_metabolism0.78680191
71MP0009642_abnormal_blood_homeostasis0.78305027
72MP0005376_homeostasis/metabolism_phenot0.77603419
73MP0000003_abnormal_adipose_tissue0.76979127
74MP0002078_abnormal_glucose_homeostasis0.74428228
75MP0003656_abnormal_erythrocyte_physiolo0.74294577
76MP0000230_abnormal_systemic_arterial0.74111995
77MP0005666_abnormal_adipose_tissue0.73538439
78MP0002971_abnormal_brown_adipose0.73299152
79MP0009763_increased_sensitivity_to0.73052553
80MP0002796_impaired_skin_barrier0.73017747
81MP0000685_abnormal_immune_system0.71537970
82MP0008775_abnormal_heart_ventricle0.71456392
83MP0010155_abnormal_intestine_physiology0.71163506
84MP0002136_abnormal_kidney_physiology0.70304316
85MP0009053_abnormal_anal_canal0.69288634
86MP0000604_amyloidosis0.67444649
87MP0001664_abnormal_digestion0.66500500
88MP0000566_synostosis0.65940429
89MP0005408_hypopigmentation0.65406621
90MP0003183_abnormal_peptide_metabolism0.65043646
91MP0005503_abnormal_tendon_morphology0.64357793
92MP0008260_abnormal_autophagy0.62320761
93MP0009764_decreased_sensitivity_to0.61497318
94MP0008469_abnormal_protein_level0.61214618
95MP0005334_abnormal_fat_pad0.60005738
96MP0009672_abnormal_birth_weight0.59909718
97MP0009765_abnormal_xenobiotic_induced0.59547801
98MP0004957_abnormal_blastocyst_morpholog0.59400100
99MP0002269_muscular_atrophy0.58899332
100MP0003329_amyloid_beta_deposits0.57396627
101MP0005164_abnormal_response_to0.57168713
102MP0005166_decreased_susceptibility_to0.57138291
103MP0004130_abnormal_muscle_cell0.56384485
104MP0003690_abnormal_glial_cell0.55682245
105MP0010368_abnormal_lymphatic_system0.55196397
106MP0002837_dystrophic_cardiac_calcinosis0.54743848
107MP0004215_abnormal_myocardial_fiber0.54731345
108MP0005620_abnormal_muscle_contractility0.54669780
109MP0004510_myositis0.53701361
110MP0005551_abnormal_eye_electrophysiolog0.53221872
111MP0002108_abnormal_muscle_morphology0.52438201
112MP0004883_abnormal_blood_vessel0.50776876
113MP0003638_abnormal_response/metabolism_0.48826898
114MP0005058_abnormal_lysosome_morphology0.48457662
115MP0002168_other_aberrant_phenotype0.47990769
116MP0003953_abnormal_hormone_level0.47263942
117MP0005535_abnormal_body_temperature0.46774205
118MP0003111_abnormal_nucleus_morphology0.44613400
119MP0004782_abnormal_surfactant_physiolog0.43862842
120MP0005330_cardiomyopathy0.43408456
121MP0005448_abnormal_energy_balance0.41888080
122MP0000579_abnormal_nail_morphology0.41177132
123MP0002970_abnormal_white_adipose0.40547491
124MP0001765_abnormal_ion_homeostasis0.39841309
125MP0010234_abnormal_vibrissa_follicle0.39510798
126MP0002132_abnormal_respiratory_system0.39097180
127MP0000358_abnormal_cell_content/0.38556144
128MP0002060_abnormal_skin_morphology0.37629748
129MP0001542_abnormal_bone_strength0.36401752
130MP0009115_abnormal_fat_cell0.35293328
131MP0004381_abnormal_hair_follicle0.34710197
132MP0001881_abnormal_mammary_gland0.34344348
133MP0004185_abnormal_adipocyte_glucose0.33820470
134MP0003699_abnormal_female_reproductive0.33647688
135MP0002135_abnormal_kidney_morphology0.33007823
136MP0000639_abnormal_adrenal_gland0.32541424
137MP0002098_abnormal_vibrissa_morphology0.32367588
138MP0003890_abnormal_embryonic-extraembry0.31969648
139MP0001730_embryonic_growth_arrest0.31866530
140MP0001672_abnormal_embryogenesis/_devel0.31305872
141MP0005380_embryogenesis_phenotype0.31305872
142MP0000647_abnormal_sebaceous_gland0.31222732

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.68693945
2Intrahepatic cholestasis (HP:0001406)6.26880583
3Abnormality of monocarboxylic acid metabolism (HP:0010996)5.96432825
4Xanthomatosis (HP:0000991)5.81483125
5Hyperglycinemia (HP:0002154)5.65714937
6Deep venous thrombosis (HP:0002625)5.57961154
7Hyperglycinuria (HP:0003108)5.54518990
8Hypobetalipoproteinemia (HP:0003563)5.52179404
9Prolonged partial thromboplastin time (HP:0003645)5.15526063
10Abnormality of serine family amino acid metabolism (HP:0010894)5.11056541
11Abnormality of glycine metabolism (HP:0010895)5.11056541
12Hyperlipoproteinemia (HP:0010980)5.08171187
13Hyperammonemia (HP:0001987)4.76078526
14Hypolipoproteinemia (HP:0010981)4.43404422
15Glomerulonephritis (HP:0000099)4.35890121
16Ketosis (HP:0001946)4.35678743
17Complement deficiency (HP:0004431)4.29433572
18Abnormality of sulfur amino acid metabolism (HP:0004339)4.24771941
19Hypoglycemic coma (HP:0001325)4.20924834
20Gout (HP:0001997)4.15860823
21Hypoalphalipoproteinemia (HP:0003233)4.10014052
22Abnormality of aspartate family amino acid metabolism (HP:0010899)3.98032134
23Abnormality of methionine metabolism (HP:0010901)3.97049102
24Abnormality of glutamine family amino acid metabolism (HP:0010902)3.93831393
25Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.92446081
26Abnormality of fatty-acid metabolism (HP:0004359)3.79592270
27Abnormality of serum amino acid levels (HP:0003112)3.78959166
28Fat malabsorption (HP:0002630)3.66511388
29Abnormality of pyrimidine metabolism (HP:0004353)3.65419031
30Nephritis (HP:0000123)3.63248408
31Epidermoid cyst (HP:0200040)3.59133052
32Abnormality of the common coagulation pathway (HP:0010990)3.53247494
33Abnormality of the intrinsic pathway (HP:0010989)3.42405530
34Joint hemorrhage (HP:0005261)3.39041426
35Ketoacidosis (HP:0001993)3.38150059
36Hemorrhage of the eye (HP:0011885)3.32559536
37Delayed CNS myelination (HP:0002188)3.32065839
38Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.30400846
39Dicarboxylic aciduria (HP:0003215)3.29861814
40Abnormality of dicarboxylic acid metabolism (HP:0010995)3.29861814
41Abnormality of nucleobase metabolism (HP:0010932)3.26207532
42Lethargy (HP:0001254)3.23047428
43Abnormality of complement system (HP:0005339)3.08992198
44Abnormality of purine metabolism (HP:0004352)3.06601782
45Decreased circulating renin level (HP:0003351)3.03907262
46Conjugated hyperbilirubinemia (HP:0002908)3.03357708
47Steatorrhea (HP:0002570)2.87244110
48Recurrent gram-negative bacterial infections (HP:0005420)2.82665401
49Metabolic acidosis (HP:0001942)2.81299368
50Hypercholesterolemia (HP:0003124)2.79097027
51Proximal tubulopathy (HP:0000114)2.73429479
52Generalized aminoaciduria (HP:0002909)2.70775856
53Hyperuricemia (HP:0002149)2.69349706
54Increased purine levels (HP:0004368)2.69349706
55Cerebral palsy (HP:0100021)2.69187250
56Myocardial infarction (HP:0001658)2.68004411
57Hyperbilirubinemia (HP:0002904)2.61947600
58Irritability (HP:0000737)2.61652113
59Malnutrition (HP:0004395)2.61051194
60Cerebral edema (HP:0002181)2.58019755
61Fair hair (HP:0002286)2.55997530
62Hyperglycemia (HP:0003074)2.54654282
63Facial shape deformation (HP:0011334)2.47601795
64Potter facies (HP:0002009)2.47601795
65Hypoglycemic seizures (HP:0002173)2.45592875
66Hepatocellular carcinoma (HP:0001402)2.44915537
67Vascular calcification (HP:0004934)2.42506883
68Spontaneous abortion (HP:0005268)2.41773947
69Skin nodule (HP:0200036)2.41766374
70Vomiting (HP:0002013)2.37746796
71Abnormal cartilage morphology (HP:0002763)2.36735968
72Hyperinsulinemic hypoglycemia (HP:0000825)2.32571769
73Hypochromic microcytic anemia (HP:0004840)2.30467100
74Megaloblastic anemia (HP:0001889)2.29687768
75Late onset (HP:0003584)2.29238199
76Spastic diplegia (HP:0001264)2.27873314
77Mitral stenosis (HP:0001718)2.23339399
78Heart block (HP:0012722)2.22876738
79Generalized hypopigmentation of hair (HP:0011358)2.21970454
80Bronchomalacia (HP:0002780)2.19119804
81Exercise-induced myalgia (HP:0003738)2.18374625
82Nausea (HP:0002018)2.17219766
83Brushfield spots (HP:0001088)2.15694353
84Pancreatitis (HP:0001733)2.13912999
85Cardiovascular calcification (HP:0011915)2.11467860
86Abnormality of urine glucose concentration (HP:0011016)2.10957451
87Glycosuria (HP:0003076)2.10957451
88Atrioventricular block (HP:0001678)2.10571983
89Neonatal onset (HP:0003623)2.09922597
90Abnormal atrioventricular conduction (HP:0005150)2.08985905
91Esophageal varix (HP:0002040)2.07795269
92Obstructive sleep apnea (HP:0002870)2.05273454
93Pigmentary retinal degeneration (HP:0001146)2.05004264
94Opisthotonus (HP:0002179)2.02752609
95Abnormality of renin-angiotensin system (HP:0000847)2.02098102
96Rickets (HP:0002748)2.00514418
97Hyperventilation (HP:0002883)1.99228242
98Gingival bleeding (HP:0000225)1.98183461
99Joint swelling (HP:0001386)1.96644396
100Enlarged kidneys (HP:0000105)1.95889381
101Asymmetric septal hypertrophy (HP:0001670)1.94111789
102Systemic lupus erythematosus (HP:0002725)1.93377657
103Multiple enchondromatosis (HP:0005701)1.92476081
104Abnormal enzyme/coenzyme activity (HP:0012379)1.92339994
105Alkalosis (HP:0001948)1.92081885
106Abnormality of polysaccharide metabolism (HP:0011012)1.91616913
107Abnormality of glycosaminoglycan metabolism (HP:0004371)1.91616913
108Abnormality of mucopolysaccharide metabolism (HP:0011020)1.91616913
109Neonatal hypoglycemia (HP:0001998)1.91527275
110Mucopolysacchariduria (HP:0008155)1.90198289
111Urinary glycosaminoglycan excretion (HP:0003541)1.90198289
112Lymphangioma (HP:0100764)1.89563841
113Spastic paraparesis (HP:0002313)1.88933955
114Hydroxyprolinuria (HP:0003080)1.88462710
115Abnormality of proline metabolism (HP:0010907)1.88462710
116Hyperkalemia (HP:0002153)1.87921671
117Abnormality of vitamin metabolism (HP:0100508)1.85441124
118Prolonged QT interval (HP:0001657)1.83381217
119Arthropathy (HP:0003040)1.82337729
120Abnormality of transition element cation homeostasis (HP:0011030)1.78262308
121Sensorimotor neuropathy (HP:0007141)1.78033436
122Methylmalonic aciduria (HP:0012120)1.76608537
123Renal cortical cysts (HP:0000803)1.75326226
124Abnormal gallbladder morphology (HP:0012437)1.74984775
125Pulmonary embolism (HP:0002204)1.73753177
126Abnormality of alkaline phosphatase activity (HP:0004379)1.72958337
127Widely patent fontanelles and sutures (HP:0004492)1.72674649
128Cholelithiasis (HP:0001081)1.72045711
129Menorrhagia (HP:0000132)1.71250333
130Symptomatic seizures (HP:0011145)1.70348638
131Back pain (HP:0003418)1.70078107
132Purpura (HP:0000979)1.69894626
133Syncope (HP:0001279)1.69052334
134Hyperactive renin-angiotensin system (HP:0000841)1.67891237
135Confusion (HP:0001289)1.67650815
136Acute hepatic failure (HP:0006554)1.67556775
137J-shaped sella turcica (HP:0002680)1.67318456
138Stroke (HP:0001297)1.66552511
139CNS demyelination (HP:0007305)1.66137491
140Ileus (HP:0002595)1.65848779
141Rectal prolapse (HP:0002035)1.65454948
142Aortic aneurysm (HP:0004942)1.64520088
143Bundle branch block (HP:0011710)1.64210450
144Abnormality of potassium homeostasis (HP:0011042)1.63484854
145Hypertriglyceridemia (HP:0002155)1.61453598
146Abnormal urine output (HP:0012590)1.60881266
147Abnormality of iron homeostasis (HP:0011031)1.60609707
148Amelogenesis imperfecta (HP:0000705)1.58824860
149Abnormality of renal excretion (HP:0011036)1.55805087
150Blue irides (HP:0000635)1.55802233
151Hypokalemia (HP:0002900)1.55494811

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.01389380
2EPHA24.26573506
3ERN13.21586398
4FGFR43.06904216
5AKT32.82481384
6SIK12.62145496
7BUB12.47724373
8STK38L2.40270428
9WEE12.35228715
10MYLK2.21951858
11RIPK12.06180101
12NEK12.05755029
13MAP3K71.94101252
14MST1R1.90324397
15PDK31.88112156
16PDK41.88112156
17PINK11.84429720
18TNK21.84315703
19INSRR1.71059757
20IRAK31.66516353
21NME21.66389589
22DAPK21.61425077
23EEF2K1.59231245
24ERBB41.58410123
25STK161.58378174
26TRIB31.57675575
27OBSCN1.56348997
28TTK1.55386388
29LATS11.54146409
30CDC42BPA1.53389540
31MAPK111.44237066
32PDK21.43538393
33PIK3CA1.40970762
34MAP3K31.39832877
35TRPM71.35048350
36MAP3K131.33140466
37FGFR31.28169447
38MAPK151.27291076
39EIF2AK11.24229859
40TTN1.23700131
41ABL21.19601211
42WNK31.17435779
43MAP4K11.13418379
44EPHB11.11103525
45MARK21.09595819
46NLK1.09085717
47MAP2K21.08028715
48PHKG11.07349495
49PHKG21.07349495
50TAOK21.07113495
51TAOK31.06321784
52LATS21.05999383
53EIF2AK31.04863428
54MUSK1.04253700
55MET1.02943677
56ZAK1.00583334
57PDPK10.99958594
58PRKCI0.99539763
59MAP3K110.96041067
60NEK20.94698090
61FLT30.94477130
62MAP3K60.94411865
63PRKD20.93878799
64ZAP700.93876150
65DMPK0.93866165
66HIPK20.91093816
67PIK3CG0.89994387
68NTRK30.89871574
69BLK0.89694575
70DYRK30.89305080
71PLK40.87683439
72BRAF0.85829894
73PKN20.84848397
74ADRBK20.84661958
75JAK10.84498892
76PAK30.81850661
77CDK40.80661207
78PDK10.80399697
79TBK10.79195131
80BRSK20.77251313
81CAMK2G0.76378547
82MAP2K30.76079555
83ACVR1B0.73658298
84SGK2230.73429284
85SGK4940.73429284
86KDR0.72910870
87SGK20.72889288
88TSSK60.72875506
89PRKAA10.72820981
90PLK10.70741855
91MTOR0.70099231
92RPS6KB20.69267817
93RPS6KA60.68949705
94AURKA0.66479018
95PRKAA20.66242047
96CAMKK10.64977805
97CAMK10.63234763
98CHUK0.63189197
99MAP3K80.62591984
100KIT0.61927770
101STK380.61444817
102NEK90.61326405
103TXK0.61261600
104FER0.60829159
105IKBKE0.60128744
106RPS6KA20.60055833
107MAP2K60.59498845
108ERBB20.59148639
109MAP2K40.59148354
110PTK20.58940250
111PRKD10.58470098
112FRK0.57999161
113CAMK1D0.56697470
114STK390.54893825
115BMPR1B0.54543233
116TYK20.54494480
117PTK60.53446403
118GRK60.53405699
119FGFR20.53288083
120CDK70.52500720
121SIK20.52480396
122WNK10.52346069
123RPS6KL10.52299300
124RPS6KC10.52299300
125AURKB0.51947797
126STK30.50318909
127OXSR10.50294024
128SGK30.50089182
129GSK3A0.49282886
130PNCK0.49123258
131PRKCZ0.48855923
132CDK60.47815643
133ITK0.47462212
134IKBKB0.47358274
135ADRBK10.46238176
136MAP2K10.44000909
137SGK10.43454127
138RET0.43369668
139CSNK1E0.42872230
140WNK40.42200346
141MAP3K50.41193175
142PRKACG0.39305509
143SRPK10.38969521
144DYRK1B0.37071002
145MAPK70.35460912
146ARAF0.34138651
147CSNK2A10.32967495
148JAK20.32816346
149MAPKAPK30.32588680
150NUAK10.31925934
151AKT20.31460147
152TIE10.31174754
153GRK10.30847991
154CSNK2A20.29182592
155EPHA30.28515664
156CHEK20.27786228
157NME10.27638733
158MAPK40.26780824
159PRKCG0.26344007
160MAPK120.25831325

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.83847083
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.96826228
3Nitrogen metabolism_Homo sapiens_hsa009102.93691889
4Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.91421048
5Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.87024959
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.86167943
7Arginine biosynthesis_Homo sapiens_hsa002202.66020714
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.61942739
9Tryptophan metabolism_Homo sapiens_hsa003802.50115742
10Fatty acid degradation_Homo sapiens_hsa000712.44849151
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.15454716
12Complement and coagulation cascades_Homo sapiens_hsa046102.15307717
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.13184089
14Butanoate metabolism_Homo sapiens_hsa006502.11368664
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.09535538
16Propanoate metabolism_Homo sapiens_hsa006402.08985907
17Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.07926831
18Peroxisome_Homo sapiens_hsa041462.04534817
19Drug metabolism - other enzymes_Homo sapiens_hsa009831.86730710
20Selenocompound metabolism_Homo sapiens_hsa004501.86571178
21Vitamin B6 metabolism_Homo sapiens_hsa007501.86203532
22Folate biosynthesis_Homo sapiens_hsa007901.85831818
23Fatty acid metabolism_Homo sapiens_hsa012121.84331428
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.77084744
25beta-Alanine metabolism_Homo sapiens_hsa004101.74577560
26Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.73826082
27PPAR signaling pathway_Homo sapiens_hsa033201.71284215
28Chemical carcinogenesis_Homo sapiens_hsa052041.66719957
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.62944094
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.61842310
31Histidine metabolism_Homo sapiens_hsa003401.61210659
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.60760340
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.52907914
34Biosynthesis of amino acids_Homo sapiens_hsa012301.50706305
35Retinol metabolism_Homo sapiens_hsa008301.46507301
36Carbon metabolism_Homo sapiens_hsa012001.45446004
37Cyanoamino acid metabolism_Homo sapiens_hsa004601.44111301
38Caffeine metabolism_Homo sapiens_hsa002321.42791870
39Phenylalanine metabolism_Homo sapiens_hsa003601.39523474
40Pyruvate metabolism_Homo sapiens_hsa006201.38450288
41Fat digestion and absorption_Homo sapiens_hsa049751.30610763
42Maturity onset diabetes of the young_Homo sapiens_hsa049501.30120176
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.29752532
44Tyrosine metabolism_Homo sapiens_hsa003501.23901551
45Arginine and proline metabolism_Homo sapiens_hsa003301.22944615
46One carbon pool by folate_Homo sapiens_hsa006701.20860960
47Fatty acid elongation_Homo sapiens_hsa000621.20841079
48Sulfur relay system_Homo sapiens_hsa041221.20240614
49Bile secretion_Homo sapiens_hsa049761.19986813
50Vitamin digestion and absorption_Homo sapiens_hsa049771.18250387
51Sulfur metabolism_Homo sapiens_hsa009201.16236306
52Starch and sucrose metabolism_Homo sapiens_hsa005001.12126150
53Staphylococcus aureus infection_Homo sapiens_hsa051501.10268790
54Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.09874352
55Glutathione metabolism_Homo sapiens_hsa004801.04690165
56Pentose phosphate pathway_Homo sapiens_hsa000301.00475777
57Steroid biosynthesis_Homo sapiens_hsa001000.94235443
58Glycerolipid metabolism_Homo sapiens_hsa005610.92207625
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.91926249
60Fructose and mannose metabolism_Homo sapiens_hsa000510.90112358
61ABC transporters_Homo sapiens_hsa020100.87806566
62Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.85309741
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81206212
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79308114
65Lysine degradation_Homo sapiens_hsa003100.76808306
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.69961115
67Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.67828203
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.66439651
69Metabolic pathways_Homo sapiens_hsa011000.65199138
70Proteasome_Homo sapiens_hsa030500.64484748
71Regulation of autophagy_Homo sapiens_hsa041400.61648303
72Galactose metabolism_Homo sapiens_hsa000520.54428015
73Other glycan degradation_Homo sapiens_hsa005110.51639727
74Ovarian steroidogenesis_Homo sapiens_hsa049130.50373419
75Fatty acid biosynthesis_Homo sapiens_hsa000610.50351035
76Glycerophospholipid metabolism_Homo sapiens_hsa005640.49857994
77Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46581619
78Ether lipid metabolism_Homo sapiens_hsa005650.39091794
79Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37259609
80Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.36685984
81Pyrimidine metabolism_Homo sapiens_hsa002400.36614315
82alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.35844892
83Aldosterone synthesis and secretion_Homo sapiens_hsa049250.33262133
84Pertussis_Homo sapiens_hsa051330.31922599
85Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.28655792
86Linoleic acid metabolism_Homo sapiens_hsa005910.28476707
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.28081974
88Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.25328924
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.25232503
90Renin secretion_Homo sapiens_hsa049240.23600296
91Prion diseases_Homo sapiens_hsa050200.22777043
92Insulin secretion_Homo sapiens_hsa049110.22510644
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.20071099
94Serotonergic synapse_Homo sapiens_hsa047260.19988725
95RNA polymerase_Homo sapiens_hsa030200.18601590
96Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.18536102
97Insulin resistance_Homo sapiens_hsa049310.17026350
98Pancreatic secretion_Homo sapiens_hsa049720.15390519
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.13051800
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.12618208
101Arachidonic acid metabolism_Homo sapiens_hsa005900.12216754
102Intestinal immune network for IgA production_Homo sapiens_hsa046720.11641587
103Thyroid hormone synthesis_Homo sapiens_hsa049180.10107138
104AMPK signaling pathway_Homo sapiens_hsa041520.09657317
105Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.09419526
106Dilated cardiomyopathy_Homo sapiens_hsa054140.09001295
107Calcium signaling pathway_Homo sapiens_hsa040200.07252219
108Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.07141178
109RNA transport_Homo sapiens_hsa030130.06661249
110Renin-angiotensin system_Homo sapiens_hsa046140.06641395
111Sphingolipid metabolism_Homo sapiens_hsa006000.06166393
112Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.05760850
113Glucagon signaling pathway_Homo sapiens_hsa049220.04660989
114Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.04375211
115Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.04132451
116Protein digestion and absorption_Homo sapiens_hsa049740.04000221
117Circadian rhythm_Homo sapiens_hsa047100.00653158
118Mineral absorption_Homo sapiens_hsa04978-0.1205510
119Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1190745
120Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.1059954
121Insulin signaling pathway_Homo sapiens_hsa04910-0.0838570
122Mismatch repair_Homo sapiens_hsa03430-0.0802034
123Ribosome_Homo sapiens_hsa03010-0.0350923
124Purine metabolism_Homo sapiens_hsa00230-0.0217044

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