ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	L-phenylalanine catabolic process (GO:0006559)	7.28212173
2	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	7.28212173
3	L-phenylalanine metabolic process (GO:0006558)	7.01098882
4	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	7.01098882
5	exogenous drug catabolic process (GO:0042738)	6.76967714
6	aromatic amino acid family catabolic process (GO:0009074)	6.55287323
7	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	6.24705112
8	indole-containing compound catabolic process (GO:0042436)	5.92497559
9	indolalkylamine catabolic process (GO:0046218)	5.92497559
10	tryptophan catabolic process (GO:0006569)	5.92497559
11	kynurenine metabolic process (GO:0070189)	5.86682908
12	glyoxylate metabolic process (GO:0046487)	5.73087156
13	bile acid biosynthetic process (GO:0006699)	5.63599158
14	tryptophan metabolic process (GO:0006568)	5.58775307
15	alpha-linolenic acid metabolic process (GO:0036109)	5.53100932
16	epoxygenase P450 pathway (GO:0019373)	5.48290062
17	cysteine metabolic process (GO:0006534)	5.43477608
18	urea metabolic process (GO:0019627)	5.43081225
19	urea cycle (GO:0000050)	5.43081225
20	high-density lipoprotein particle remodeling (GO:0034375)	5.39290282
21	negative regulation of fibrinolysis (GO:0051918)	5.35721968
22	omega-hydroxylase P450 pathway (GO:0097267)	5.35693406
23	sulfur amino acid catabolic process (GO:0000098)	5.33986001
24	serine family amino acid catabolic process (GO:0009071)	5.15604259
25	protein carboxylation (GO:0018214)	5.12205856
26	peptidyl-glutamic acid carboxylation (GO:0017187)	5.12205856
27	regulation of fibrinolysis (GO:0051917)	5.09276423
28	nitrogen cycle metabolic process (GO:0071941)	5.00571979
29	complement activation, alternative pathway (GO:0006957)	4.95002741
30	lysine catabolic process (GO:0006554)	4.93871867
31	lysine metabolic process (GO:0006553)	4.93871867
32	regulation of protein activation cascade (GO:2000257)	4.92424111
33	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	4.91930100
34	regulation of triglyceride catabolic process (GO:0010896)	4.84260948
35	bile acid metabolic process (GO:0008206)	4.84238468
36	aromatic amino acid family metabolic process (GO:0009072)	4.81755698
37	regulation of cholesterol esterification (GO:0010872)	4.79223470
38	amino-acid betaine metabolic process (GO:0006577)	4.75750620
39	regulation of sequestering of triglyceride (GO:0010889)	4.73540040
40	reverse cholesterol transport (GO:0043691)	4.70198278
41	low-density lipoprotein particle clearance (GO:0034383)	4.68213430
42	homocysteine metabolic process (GO:0050667)	4.65285870
43	tyrosine metabolic process (GO:0006570)	4.63725213
44	protein-lipid complex remodeling (GO:0034368)	4.62626022
45	macromolecular complex remodeling (GO:0034367)	4.62626022
46	plasma lipoprotein particle remodeling (GO:0034369)	4.62626022
47	cellular ketone body metabolic process (GO:0046950)	4.61107153
48	alpha-amino acid catabolic process (GO:1901606)	4.60317374
49	regulation of complement activation (GO:0030449)	4.58130778
50	triglyceride catabolic process (GO:0019433)	4.57115487
51	triglyceride homeostasis (GO:0070328)	4.53715855
52	acylglycerol homeostasis (GO:0055090)	4.53715855
53	negative regulation of cholesterol transport (GO:0032375)	4.46358294
54	negative regulation of sterol transport (GO:0032372)	4.46358294
55	phospholipid efflux (GO:0033700)	4.44247765
56	plasma lipoprotein particle clearance (GO:0034381)	4.39681420
57	oxaloacetate metabolic process (GO:0006107)	4.38024102
58	glycine metabolic process (GO:0006544)	4.33459920
59	ethanol metabolic process (GO:0006067)	4.30897353
60	polyketide metabolic process (GO:0030638)	4.27911425
61	doxorubicin metabolic process (GO:0044598)	4.27911425
62	daunorubicin metabolic process (GO:0044597)	4.27911425
63	cellular amino acid catabolic process (GO:0009063)	4.27469144
64	coenzyme catabolic process (GO:0009109)	4.23625538
65	neutral lipid catabolic process (GO:0046461)	4.20037895
66	acylglycerol catabolic process (GO:0046464)	4.20037895
67	serine family amino acid metabolic process (GO:0009069)	4.18339553
68	indolalkylamine metabolic process (GO:0006586)	4.17544186
69	regulation of plasminogen activation (GO:0010755)	4.16145351
70	bile acid and bile salt transport (GO:0015721)	4.15980037
71	cellular biogenic amine catabolic process (GO:0042402)	4.12623048
72	amine catabolic process (GO:0009310)	4.12623048
73	ethanol oxidation (GO:0006069)	4.12594709
74	glutamate metabolic process (GO:0006536)	4.10984240
75	benzene-containing compound metabolic process (GO:0042537)	4.07258412
76	cellular glucuronidation (GO:0052695)	4.06088283
77	NADH metabolic process (GO:0006734)	4.04468390
78	short-chain fatty acid metabolic process (GO:0046459)	4.03883625
79	aminoglycoside antibiotic metabolic process (GO:0030647)	4.03423484
80	imidazole-containing compound metabolic process (GO:0052803)	4.02449730
81	fatty acid homeostasis (GO:0055089)	4.02066170
82	cellular modified amino acid catabolic process (GO:0042219)	4.01826012
83	cholesterol efflux (GO:0033344)	4.01332444
84	ketone body metabolic process (GO:1902224)	4.01071350
85	drug metabolic process (GO:0017144)	3.99501997
86	drug catabolic process (GO:0042737)	3.99402900
87	serine family amino acid biosynthetic process (GO:0009070)	3.98389096
88	response to mercury ion (GO:0046689)	3.95837294
89	blood coagulation, intrinsic pathway (GO:0007597)	3.92488007
90	dicarboxylic acid biosynthetic process (GO:0043650)	3.90380743
91	acetyl-CoA metabolic process (GO:0006084)	3.89113623
92	arginine metabolic process (GO:0006525)	3.88825538
93	plasma lipoprotein particle assembly (GO:0034377)	3.86372054
94	carboxylic acid catabolic process (GO:0046395)	3.83519041
95	organic acid catabolic process (GO:0016054)	3.83519041
96	low-density lipoprotein particle remodeling (GO:0034374)	3.81839642
97	positive regulation of lipid catabolic process (GO:0050996)	3.80954161
98	fibrinolysis (GO:0042730)	3.80178303
99	aldehyde catabolic process (GO:0046185)	3.75823640
100	2-oxoglutarate metabolic process (GO:0006103)	3.75705616
101	positive regulation of lipoprotein lipase activity (GO:0051006)	3.74733682
102	positive regulation of triglyceride lipase activity (GO:0061365)	3.74733682
103	phospholipid homeostasis (GO:0055091)	3.73915432
104	fatty acid beta-oxidation (GO:0006635)	3.73294920
105	primary alcohol catabolic process (GO:0034310)	3.73028225
106	negative regulation of lipase activity (GO:0060192)	3.72272468
107	aspartate family amino acid catabolic process (GO:0009068)	3.71166421
108	S-adenosylmethionine metabolic process (GO:0046500)	3.69786248
109	fatty acid oxidation (GO:0019395)	3.69023834
110	oxidative demethylation (GO:0070989)	3.68166452
111	acute-phase response (GO:0006953)	3.66890686
112	cholesterol homeostasis (GO:0042632)	3.65850433
113	monocarboxylic acid catabolic process (GO:0072329)	3.65515765
114	positive regulation of fatty acid beta-oxidation (GO:0032000)	3.62766927
115	very-low-density lipoprotein particle assembly (GO:0034379)	3.62399118
116	cofactor catabolic process (GO:0051187)	3.62126542
117	lipid oxidation (GO:0034440)	3.61844703
118	lipid storage (GO:0019915)	3.61145418
119	carnitine metabolic process (GO:0009437)	3.61092305
120	sterol homeostasis (GO:0055092)	3.60511272
121	creatine metabolic process (GO:0006600)	3.59973093
122	regulation of cholesterol homeostasis (GO:2000188)	3.59540857
123	uronic acid metabolic process (GO:0006063)	3.59397864
124	glucuronate metabolic process (GO:0019585)	3.59397864
125	regulation of bile acid biosynthetic process (GO:0070857)	3.57989051
126	phenylpropanoid metabolic process (GO:0009698)	3.56024424
127	fatty acid catabolic process (GO:0009062)	3.55534111
128	negative regulation of blood coagulation (GO:0030195)	3.54004466
129	negative regulation of hemostasis (GO:1900047)	3.54004466
130	primary alcohol metabolic process (GO:0034308)	3.50494535
131	biotin metabolic process (GO:0006768)	3.38919880
132	fat-soluble vitamin biosynthetic process (GO:0042362)	3.36223699
133	negative regulation of coagulation (GO:0050819)	3.31045469
134	positive regulation of lipid storage (GO:0010884)	3.22992509
135	valine metabolic process (GO:0006573)	3.19283919
136	fatty acid transmembrane transport (GO:1902001)	3.18962405
137	glycerolipid catabolic process (GO:0046503)	3.15098905
138	positive regulation of hemostasis (GO:1900048)	3.13026042
139	positive regulation of blood coagulation (GO:0030194)	3.13026042
140	protein activation cascade (GO:0072376)	3.08752772
141	negative regulation of wound healing (GO:0061045)	3.07189380
142	xenobiotic catabolic process (GO:0042178)	3.05420007
143	intestinal cholesterol absorption (GO:0030299)	3.02046703
144	positive regulation of coagulation (GO:0050820)	2.97005553
145	negative regulation of fatty acid biosynthetic process (GO:0045717)	2.94414412

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	RXR_22158963_ChIP-Seq_LIVER_Mouse	8.25186233
2	* PPARA_22158963_ChIP-Seq_LIVER_Mouse	7.10535392
3	* EGR1_23403033_ChIP-Seq_LIVER_Mouse	6.63290057
4	LXR_22158963_ChIP-Seq_LIVER_Mouse	6.38519266
5	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	5.77279764
6	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	5.10145512
7	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	4.97537836
8	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	3.96116575
9	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	3.89360706
10	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.58881385
11	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	2.09301663
12	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	2.00949470
13	* ESR1_17901129_ChIP-ChIP_LIVER_Mouse	11.5822102
14	CLOCK_20551151_ChIP-Seq_293T_Human	1.83791128
15	* FOXA2_19822575_ChIP-Seq_HepG2_Human	1.56187230
16	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.46204632
17	HTT_18923047_ChIP-ChIP_STHdh_Human	1.41232819
18	* HNF4A_19822575_ChIP-Seq_HepG2_Human	1.40202758
19	* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.33022702
20	GATA1_22025678_ChIP-Seq_K562_Human	1.30192984
21	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.24614528
22	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.20903115
23	RXRA_24833708_ChIP-Seq_LIVER_Mouse	1.19297497
24	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.13727923
25	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.12903172
26	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.12067374
27	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.12048192
28	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.07528049
29	ZNF263_19887448_ChIP-Seq_K562_Human	1.07462792
30	* RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.05218378
31	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.02833674
32	P63_26484246_Chip-Seq_KERATINOCYTES_Human	1.02615391
33	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.01642868
34	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.99051706
35	SOX2_27498859_Chip-Seq_STOMACH_Mouse	0.98010578
36	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.97948058
37	GATA2_21666600_ChIP-Seq_HMVEC_Human	0.97182341
38	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.96788732
39	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	0.96401119
40	TP63_17297297_ChIP-ChIP_HaCaT_Human	0.96315439
41	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.93135169
42	SPI1_20517297_ChIP-Seq_HL60_Human	0.92820558
43	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	0.92689299
44	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.91178195
45	NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse	0.91131521
46	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	0.91053494
47	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	0.91035397
48	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.90422144
49	GATA4_25053715_ChIP-Seq_YYC3_Human	0.89484472
50	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	0.88570790
51	* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	0.88270128
52	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.87688270
53	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.86933601
54	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.85427618
55	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	0.84383966
56	SA1_27219007_Chip-Seq_Bcells_Human	0.83626489
57	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.83245894
58	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	0.83092225
59	P68_20966046_ChIP-Seq_HELA_Human	0.82699041
60	ESR2_21235772_ChIP-Seq_MCF-7_Human	0.81856325
61	SMC4_20622854_ChIP-Seq_HELA_Human	0.81549940
62	PPARG_20176806_ChIP-Seq_3T3-L1_Mouse	0.81172675
63	* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	0.80720242
64	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.80587567
65	STAT1_20625510_ChIP-Seq_HELA_Human	0.80292295
66	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	0.79780295
67	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.79629113
68	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	0.78165499
69	SOX2_20726797_ChIP-Seq_SW620_Human	0.78110646
70	VDR_21846776_ChIP-Seq_THP-1_Human	0.77012700
71	BRD4_27068464_Chip-Seq_AML-cells_Mouse	0.76002705
72	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.75780449
73	RARA_24833708_ChIP-Seq_LIVER_Mouse	0.74472733
74	SMC3_22415368_ChIP-Seq_MEFs_Mouse	0.74462342
75	SALL4_18804426_ChIP-ChIP_XEN_Mouse	0.72957927
76	CTCF_27219007_Chip-Seq_Bcells_Human	0.72490214
77	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	0.70927251
78	SA1_27219007_Chip-Seq_ERYTHROID_Human	0.70150323
79	RAC3_21632823_ChIP-Seq_H3396_Human	0.69824330
80	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.69305785
81	SOX2_21211035_ChIP-Seq_LN229_Human	0.69275804
82	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.69267224
83	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.68533187
84	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.68526833
85	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.68305777
86	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	0.66050936
87	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.64268381
88	RARB_24833708_ChIP-Seq_LIVER_Mouse	0.63208905
89	CEBPB_22108803_ChIP-Seq_LS180_Human	0.62943001
90	ESR1_21235772_ChIP-Seq_MCF-7_Human	0.62623012
91	* RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.61739737
92	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.61383761
93	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.61383761
94	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.60767826
95	PPARG_20887899_ChIP-Seq_3T3-L1_Mouse	0.59777337
96	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	0.57787900
97	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.57404891
98	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.56806373
99	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.55042123
100	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.54935590
101	ESET_19884257_ChIP-Seq_ESCs_Mouse	0.53712811
102	FOXA1_25552417_ChIP-Seq_VCAP_Human	0.53597313
103	FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	0.53572785
104	LXR_22292898_ChIP-Seq_THP-1_Human	0.52957017
105	AR_20517297_ChIP-Seq_VCAP_Human	0.52633819
106	STAT1_17558387_ChIP-Seq_HELA_Human	0.52228432
107	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	0.49786155
108	TBX20_22080862_ChIP-Seq_HEART_Mouse	0.49601996
109	TBX20_22328084_ChIP-Seq_HEART_Mouse	0.49601996
110	FOXO3_23340844_ChIP-Seq_DLD1_Human	0.48977025
111	GATA6_25053715_ChIP-Seq_YYC3_Human	0.48340112
112	P53_21459846_ChIP-Seq_SAOS-2_Human	0.47785060
113	* CBP_21632823_ChIP-Seq_H3396_Human	0.45923007
114	CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.44331779
115	EGR1_19032775_ChIP-ChIP_M12_Human	0.43659675
116	MYC_19915707_ChIP-ChIP_AK7_Human	0.43438905
117	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.42473727
118	TAF2_19829295_ChIP-Seq_ESCs_Human	0.42472127
119	ERG_20517297_ChIP-Seq_VCAP_Human	0.42276541
120	GATA3_24758297_ChIP-Seq_MCF-7_Human	0.42004024
121	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.41027500
122	GATA2_19941826_ChIP-Seq_K562_Human	0.40593089
123	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.40325650
124	GATA1_19941826_ChIP-Seq_K562_Human	0.40238004
125	GATA1_19941827_ChIP-Seq_MEL_Mouse	0.40009639
126	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.39973634
127	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	0.39890257
128	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.39137738
129	MYC_27129775_Chip-Seq_CORNEA_Mouse	0.38855468
130	OCT4_20526341_ChIP-Seq_ESCs_Human	0.38413150
131	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.37847606
132	BCOR_27268052_Chip-Seq_Bcells_Human	0.37786633
133	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.37679268
134	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.37370470
135	SPI1_26923725_Chip-Seq_HPCs_Mouse	0.36180313
136	RACK7_27058665_Chip-Seq_MCF-7_Human	0.36125594

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	8.15636041
2	MP0005360_urolithiasis	7.39639527
3	MP0005085_abnormal_gallbladder_physiolo	6.13305199
4	MP0005365_abnormal_bile_salt	6.04268476
5	MP0008875_abnormal_xenobiotic_pharmacok	4.93685315
6	MP0003806_abnormal_nucleotide_metabolis	4.19130550
7	MP0003252_abnormal_bile_duct	3.67078744
8	MP0010329_abnormal_lipoprotein_level	3.54710514
9	MP0009840_abnormal_foam_cell	3.37196502
10	MP0005083_abnormal_biliary_tract	3.00734449
11	MP0003195_calcinosis	2.94201585
12	MP0005332_abnormal_amino_acid	2.88675897
13	MP0001666_abnormal_nutrient_absorption	2.53651090
14	MP0003191_abnormal_cellular_cholesterol	2.36303062
15	MP0004019_abnormal_vitamin_homeostasis	2.17920415
16	MP0000609_abnormal_liver_physiology	2.15672555
17	MP0002118_abnormal_lipid_homeostasis	2.14264425
18	MP0002138_abnormal_hepatobiliary_system	1.87066035
19	MP0005319_abnormal_enzyme/_coenzyme	1.85930797
20	MP0005451_abnormal_body_composition	1.70127662
21	MP0003868_abnormal_feces_composition	1.69651118
22	MP0000751_myopathy	1.68665612
23	MP0001764_abnormal_homeostasis	1.63563869
24	MP0005584_abnormal_enzyme/coenzyme_acti	1.57551257
25	MP0009697_abnormal_copulation	1.49792785
26	MP0004036_abnormal_muscle_relaxation	1.45236882
27	MP0004084_abnormal_cardiac_muscle	1.43092760
28	MP0000013_abnormal_adipose_tissue	1.42971594
29	MP0000003_abnormal_adipose_tissue	1.42116134
30	MP0003959_abnormal_lean_body	1.41534237
31	MP0006138_congestive_heart_failure	1.40906508
32	MP0009643_abnormal_urine_homeostasis	1.39113734
33	MP0003186_abnormal_redox_activity	1.39080011
34	MP0005670_abnormal_white_adipose	1.31214837
35	MP0003011_delayed_dark_adaptation	1.29288657
36	MP0004087_abnormal_muscle_fiber	1.27679920
37	MP0003705_abnormal_hypodermis_morpholog	1.27245893
38	MP0003656_abnormal_erythrocyte_physiolo	1.18478265
39	MP0000598_abnormal_liver_morphology	1.15887003
40	MP0000749_muscle_degeneration	1.14926328
41	MP0006036_abnormal_mitochondrial_physio	1.09783629
42	MP0005647_abnormal_sex_gland	1.09689312
43	MP0001544_abnormal_cardiovascular_syste	1.08457710
44	MP0005385_cardiovascular_system_phenoty	1.08457710
45	MP0004233_abnormal_muscle_weight	1.07753498
46	MP0002837_dystrophic_cardiac_calcinosis	1.06968145
47	MP0000343_altered_response_to	1.06047904
48	MP0002332_abnormal_exercise_endurance	1.05152329
49	MP0004130_abnormal_muscle_cell	1.04087740
50	MP0004510_myositis	1.02238593
51	MP0000604_amyloidosis	1.01702352
52	MP0002972_abnormal_cardiac_muscle	0.99355509
53	MP0005636_abnormal_mineral_homeostasis	0.98525029
54	MP0010368_abnormal_lymphatic_system	0.98513035
55	MP0009764_decreased_sensitivity_to	0.97359038
56	MP0009763_increased_sensitivity_to	0.97196002
57	MP0003828_pulmonary_edema	0.96635632
58	MP0003950_abnormal_plasma_membrane	0.95750501
59	MP0000750_abnormal_muscle_regeneration	0.94953037
60	MP0002254_reproductive_system_inflammat	0.91134309
61	MP0004215_abnormal_myocardial_fiber	0.88805994
62	MP0002971_abnormal_brown_adipose	0.88684598
63	MP0000759_abnormal_skeletal_muscle	0.88149859
64	MP0009642_abnormal_blood_homeostasis	0.87491319
65	MP0005408_hypopigmentation	0.87328012
66	MP0004145_abnormal_muscle_electrophysio	0.86187687
67	MP0002078_abnormal_glucose_homeostasis	0.86061256
68	MP0005620_abnormal_muscle_contractility	0.84680182
69	MP0008469_abnormal_protein_level	0.83590323
70	MP0000747_muscle_weakness	0.82913488
71	MP0010630_abnormal_cardiac_muscle	0.81129128
72	MP0002106_abnormal_muscle_physiology	0.79985869
73	MP0003879_abnormal_hair_cell	0.79814700
74	MP0001661_extended_life_span	0.79037923
75	MP0008775_abnormal_heart_ventricle	0.78892684
76	MP0005376_homeostasis/metabolism_phenot	0.78656842
77	MP0005334_abnormal_fat_pad	0.77423604
78	MP0005666_abnormal_adipose_tissue	0.77233435
79	MP0005084_abnormal_gallbladder_morpholo	0.76120599
80	MP0002876_abnormal_thyroid_physiology	0.75620169
81	MP0001756_abnormal_urination	0.73659888
82	MP0005535_abnormal_body_temperature	0.73590044
83	MP0005220_abnormal_exocrine_pancreas	0.72392114
84	MP0009785_altered_susceptibility_to	0.72383702
85	MP0005164_abnormal_response_to	0.72114832
86	MP0005266_abnormal_metabolism	0.70293610
87	MP0005452_abnormal_adipose_tissue	0.69018831
88	MP0003718_maternal_effect	0.66798511
89	MP0009765_abnormal_xenobiotic_induced	0.66617088
90	MP0006035_abnormal_mitochondrial_morpho	0.65829502
91	MP0005369_muscle_phenotype	0.65754392
92	MP0004484_altered_response_of	0.64686841
93	MP0003303_peritoneal_inflammation	0.64361609
94	MP0005165_increased_susceptibility_to	0.63029057
95	MP0003329_amyloid_beta_deposits	0.62554270
96	MP0003137_abnormal_impulse_conducting	0.62551236
97	MP0005395_other_phenotype	0.62402375
98	MP0001533_abnormal_skeleton_physiology	0.61718775
99	MP0005023_abnormal_wound_healing	0.61203044
100	MP0003690_abnormal_glial_cell	0.60136286
101	MP0009053_abnormal_anal_canal	0.58833145
102	MP0000639_abnormal_adrenal_gland	0.58763255
103	MP0003646_muscle_fatigue	0.58125292
104	MP0005448_abnormal_energy_balance	0.57051094
105	MP0002136_abnormal_kidney_physiology	0.55234109
106	MP0009115_abnormal_fat_cell	0.47677813
107	MP0004782_abnormal_surfactant_physiolog	0.46771640
108	MP0003953_abnormal_hormone_level	0.46320213
109	MP0005330_cardiomyopathy	0.44257645
110	MP0004185_abnormal_adipocyte_glucose	0.43551139
111	MP0002970_abnormal_white_adipose	0.41633255
112	MP0000230_abnormal_systemic_arterial	0.41130307
113	MP0002168_other_aberrant_phenotype	0.41051978
114	MP0002269_muscular_atrophy	0.40830759
115	MP0009672_abnormal_birth_weight	0.40298373
116	MP0005464_abnormal_platelet_physiology	0.40047123
117	MP0008874_decreased_physiological_sensi	0.39854670
118	MP0002796_impaired_skin_barrier	0.39604716
119	MP0003638_abnormal_response/metabolism_	0.39484437
120	MP0008873_increased_physiological_sensi	0.39475666
121	MP0002928_abnormal_bile_duct	0.37506302
122	MP0001881_abnormal_mammary_gland	0.37102446
123	MP0004043_abnormal_pH_regulation	0.35968391
124	MP0009384_cardiac_valve_regurgitation	0.35459662
125	MP0000579_abnormal_nail_morphology	0.35116917
126	MP0005248_abnormal_Harderian_gland	0.34695512
127	MP0000249_abnormal_blood_vessel	0.32614736
128	MP0003724_increased_susceptibility_to	0.32221211
129	MP0002822_catalepsy	0.32216754
130	MP0003075_altered_response_to	0.32117803
131	MP0005058_abnormal_lysosome_morphology	0.31414419
132	MP0005375_adipose_tissue_phenotype	0.29947420
133	MP0001853_heart_inflammation	0.29307957
134	MP0008872_abnormal_physiological_respon	0.28462875
135	MP0005166_decreased_susceptibility_to	0.26822532
136	MP0002135_abnormal_kidney_morphology	0.26214284
137	MP0002060_abnormal_skin_morphology	0.26004563
138	MP0003436_decreased_susceptibility_to	0.25356539

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Deep venous thrombosis (HP:0002625)	7.05381500
2	Abnormality of aromatic amino acid family metabolism (HP:0004338)	7.04434802
3	Intrahepatic cholestasis (HP:0001406)	6.81919908
4	Abnormality of monocarboxylic acid metabolism (HP:0010996)	6.22333426
5	Xanthomatosis (HP:0000991)	6.10449261
6	Prolonged partial thromboplastin time (HP:0003645)	6.01482603
7	Hypobetalipoproteinemia (HP:0003563)	5.99094571
8	Hyperlipoproteinemia (HP:0010980)	5.46608349
9	Complement deficiency (HP:0004431)	4.84079479
10	Hyperammonemia (HP:0001987)	4.82206557
11	Hypolipoproteinemia (HP:0010981)	4.69923762
12	Hyperglycinemia (HP:0002154)	4.66112317
13	Ketosis (HP:0001946)	4.54888222
14	Hyperglycinuria (HP:0003108)	4.52512845
15	Joint hemorrhage (HP:0005261)	4.45706030
16	Abnormality of glycine metabolism (HP:0010895)	4.35232166
17	Abnormality of serine family amino acid metabolism (HP:0010894)	4.35232166
18	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	4.30567783
19	Hypoalphalipoproteinemia (HP:0003233)	4.28527802
20	Hypoglycemic coma (HP:0001325)	4.24915874
21	Epidermoid cyst (HP:0200040)	4.23075665
22	Abnormality of the common coagulation pathway (HP:0010990)	4.15611183
23	Abnormality of sulfur amino acid metabolism (HP:0004339)	4.14741650
24	Abnormality of glutamine family amino acid metabolism (HP:0010902)	4.13957129
25	Abnormality of methionine metabolism (HP:0010901)	4.08028256
26	Abnormality of aspartate family amino acid metabolism (HP:0010899)	4.07396625
27	Fat malabsorption (HP:0002630)	3.84412080
28	Abnormality of fatty-acid metabolism (HP:0004359)	3.79474999
29	Abnormality of the intrinsic pathway (HP:0010989)	3.59161965
30	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	3.58669365
31	Abnormality of pyrimidine metabolism (HP:0004353)	3.53987061
32	Ketoacidosis (HP:0001993)	3.50904629
33	Abnormality of complement system (HP:0005339)	3.49093924
34	Hypercholesterolemia (HP:0003124)	3.48291980
35	Conjugated hyperbilirubinemia (HP:0002908)	3.32896648
36	Abnormality of serum amino acid levels (HP:0003112)	3.25810821
37	Hyperbilirubinemia (HP:0002904)	3.19115894
38	Hypertriglyceridemia (HP:0002155)	3.14977493
39	Abnormality of nucleobase metabolism (HP:0010932)	3.14796889
40	Delayed CNS myelination (HP:0002188)	3.14051281
41	Dicarboxylic aciduria (HP:0003215)	3.06977706
42	Abnormality of dicarboxylic acid metabolism (HP:0010995)	3.06977706
43	Oligomenorrhea (HP:0000876)	3.03796551
44	Asymmetric septal hypertrophy (HP:0001670)	2.98360880
45	Muscle fiber inclusion bodies (HP:0100299)	2.97070270
46	Myocardial infarction (HP:0001658)	2.96220639
47	Abnormality of purine metabolism (HP:0004352)	2.95201803
48	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	2.94968128
49	Metabolic acidosis (HP:0001942)	2.94820112
50	Steatorrhea (HP:0002570)	2.91196496
51	Muscle fiber splitting (HP:0003555)	2.89271070
52	Lethargy (HP:0001254)	2.87102694
53	Nemaline bodies (HP:0003798)	2.87069157
54	Rhabdomyolysis (HP:0003201)	2.86587082
55	Gout (HP:0001997)	2.85783738
56	Hepatocellular carcinoma (HP:0001402)	2.85303902
57	Exercise-induced myalgia (HP:0003738)	2.83856020
58	Spontaneous abortion (HP:0005268)	2.76560953
59	Skin nodule (HP:0200036)	2.72432145
60	Cerebral edema (HP:0002181)	2.67373217
61	Vascular calcification (HP:0004934)	2.62937023
62	Hypochromic microcytic anemia (HP:0004840)	2.58151493
63	Acanthosis nigricans (HP:0000956)	2.57639262
64	Nephritis (HP:0000123)	2.56116037
65	Myoglobinuria (HP:0002913)	2.51303609
66	Hypoglycemic seizures (HP:0002173)	2.50501514
67	Hyporeflexia of lower limbs (HP:0002600)	2.47006818
68	Generalized aminoaciduria (HP:0002909)	2.46848258
69	Abnormality of the Achilles tendon (HP:0005109)	2.45004856
70	Distal lower limb muscle weakness (HP:0009053)	2.44943687
71	Atrioventricular block (HP:0001678)	2.39167107
72	Abnormal gallbladder morphology (HP:0012437)	2.38700774
73	Systemic lupus erythematosus (HP:0002725)	2.38446529
74	Increased connective tissue (HP:0009025)	2.38127299
75	Neck muscle weakness (HP:0000467)	2.38045740
76	Cholelithiasis (HP:0001081)	2.35495238
77	EMG: myopathic abnormalities (HP:0003458)	2.34821563
78	Cardiovascular calcification (HP:0011915)	2.34299351
79	Type 1 muscle fiber predominance (HP:0003803)	2.32654886
80	Spastic diplegia (HP:0001264)	2.32137663
81	Irritability (HP:0000737)	2.32014691
82	Malnutrition (HP:0004395)	2.30726147
83	Vomiting (HP:0002013)	2.28361661
84	Neonatal onset (HP:0003623)	2.28190710
85	Abnormality of skeletal muscle fiber size (HP:0012084)	2.27810154
86	Increased serum pyruvate (HP:0003542)	2.26867432
87	Late onset (HP:0003584)	2.26724592
88	Mitral stenosis (HP:0001718)	2.23383233
89	Glomerulonephritis (HP:0000099)	2.22640377
90	Sudden death (HP:0001699)	2.21233325
91	Increased variability in muscle fiber diameter (HP:0003557)	2.20642704
92	Acanthocytosis (HP:0001927)	2.20567434
93	Bundle branch block (HP:0011710)	2.20253830
94	Sensorimotor neuropathy (HP:0007141)	2.19397750
95	Pancreatitis (HP:0001733)	2.19342128
96	Brushfield spots (HP:0001088)	2.15649824
97	Hyperinsulinemic hypoglycemia (HP:0000825)	2.14751690
98	Esophageal varix (HP:0002040)	2.13859788
99	Abnormal gallbladder physiology (HP:0012438)	2.13147151
100	Cholecystitis (HP:0001082)	2.13147151
101	Abnormal atrioventricular conduction (HP:0005150)	2.11823787
102	Abnormality of alanine metabolism (HP:0010916)	2.09808613
103	Hyperalaninemia (HP:0003348)	2.09808613
104	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.09808613
105	Heart block (HP:0012722)	2.09769759
106	Proximal tubulopathy (HP:0000114)	2.08730427
107	Amyloidosis (HP:0011034)	2.08694977
108	Cerebral palsy (HP:0100021)	2.07714965
109	Hydroxyprolinuria (HP:0003080)	2.06647351
110	Abnormality of proline metabolism (HP:0010907)	2.06647351
111	Insulin-resistant diabetes mellitus (HP:0000831)	2.05774512
112	Increased purine levels (HP:0004368)	2.03601338
113	Hyperuricemia (HP:0002149)	2.03601338
114	Rimmed vacuoles (HP:0003805)	2.03268795
115	Enlarged kidneys (HP:0000105)	2.02989168
116	Abnormal cartilage morphology (HP:0002763)	2.02967385
117	Ragged-red muscle fibers (HP:0003200)	2.01775011
118	Renal cortical cysts (HP:0000803)	2.00765727
119	Insulin resistance (HP:0000855)	2.00619442
120	Lipoatrophy (HP:0100578)	1.99394671
121	Upper motor neuron abnormality (HP:0002127)	1.98777147
122	Hyperglycemia (HP:0003074)	1.98500775
123	Abnormality of glycolysis (HP:0004366)	1.97104598
124	Urinary glycosaminoglycan excretion (HP:0003541)	1.96737537
125	Mucopolysacchariduria (HP:0008155)	1.96737537
126	Centrally nucleated skeletal muscle fibers (HP:0003687)	1.94326860
127	Abnormality of the gallbladder (HP:0005264)	1.93973012
128	Opisthotonus (HP:0002179)	1.93595910
129	Thrombophlebitis (HP:0004418)	1.93328980
130	Hemorrhage of the eye (HP:0011885)	1.93100704
131	Menorrhagia (HP:0000132)	1.93038398
132	Gingival bleeding (HP:0000225)	1.92813666
133	Achilles tendon contracture (HP:0001771)	1.92806380
134	Difficulty running (HP:0009046)	1.92664927
135	Nausea (HP:0002018)	1.92284438
136	Back pain (HP:0003418)	1.91885926
137	Recurrent gram-negative bacterial infections (HP:0005420)	1.90086617
138	Abnormality of mucopolysaccharide metabolism (HP:0011020)	1.89940111
139	Abnormality of polysaccharide metabolism (HP:0011012)	1.89940111
140	Abnormality of glycosaminoglycan metabolism (HP:0004371)	1.89940111
141	Increased serum ferritin (HP:0003281)	1.89097425
142	Stroke (HP:0001297)	1.88872140
143	Abnormality of urine glucose concentration (HP:0011016)	1.87728820
144	Glycosuria (HP:0003076)	1.87728820
145	Axonal loss (HP:0003447)	1.87663704
146	Abnormality of transition element cation homeostasis (HP:0011030)	1.87528107
147	Abnormality of iron homeostasis (HP:0011031)	1.87436979
148	Polycythemia (HP:0001901)	1.86495516
149	Rickets (HP:0002748)	1.86275459
150	Bulbar palsy (HP:0001283)	1.85972080
151	Elevated hepatic transaminases (HP:0002910)	1.80988217
152	Alkalosis (HP:0001948)	1.80567950

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BCKDK	7.54264671
2	SIK1	4.38724913
3	FGFR4	3.95965084
4	ERN1	3.95165653
5	TAOK3	2.79098254
6	PKN2	2.73137988
7	INSRR	2.67843804
8	PRPF4B	2.66826639
9	RIPK4	2.64736913
10	TRIB3	2.61719104
11	ERBB4	2.48504179
12	LATS1	2.22404770
13	FLT3	1.99294874
14	MST1R	1.98560698
15	STK38L	1.95486182
16	MAP2K4	1.83292999
17	PINK1	1.74098954
18	PIK3CG	1.69783534
19	EEF2K	1.67352953
20	MAPK11	1.64033289
21	ABL2	1.49239267
22	PHKG2	1.46639248
23	PHKG1	1.46639248
24	MAPKAPK3	1.45473726
25	TYK2	1.45374213
26	NEK9	1.39250878
27	TRPM7	1.34483951
28	PDK3	1.32359576
29	PDK4	1.32359576
30	PRKAA2	1.32138568
31	PTK6	1.28425208
32	FRK	1.25352286
33	MUSK	1.24872549
34	KDR	1.19693850
35	NME2	1.16048084
36	MAP3K1	1.11076733
37	DAPK2	1.08026745
38	CAMK1D	1.07295045
39	MAP2K3	1.05261921
40	MOS	1.03963857
41	JAK2	1.03461485
42	IRAK3	1.02357738
43	TIE1	0.98964941
44	DDR2	0.98201089
45	MAP3K7	0.96642107
46	MAP3K3	0.96626031
47	GRK7	0.95281795
48	BMPR2	0.90895761
49	FGFR2	0.89533360
50	LATS2	0.88477997
51	PRKAA1	0.88302399
52	TESK1	0.86528402
53	TBK1	0.85696210
54	EPHB2	0.84767227
55	JAK1	0.83585321
56	MAPK12	0.83032249
57	MAP3K6	0.79985979
58	MET	0.77690542
59	RPS6KB2	0.76926013
60	EPHA3	0.74777598
61	MAPK4	0.74054295
62	ARAF	0.72894576
63	PRKCZ	0.71588996
64	RIPK1	0.71403609
65	MAP3K11	0.70729852
66	PRKACG	0.70242412
67	EPHB1	0.68897069
68	ERBB2	0.67786095
69	PIK3CA	0.66941838
70	PDK2	0.65791819
71	JAK3	0.65317724
72	GRK6	0.65187582
73	PRKD3	0.63271442
74	CDK6	0.62955816
75	MAP3K5	0.59933545
76	BMX	0.58556144
77	NEK1	0.57995856
78	DMPK	0.57951225
79	AKT2	0.57776113
80	ADRBK1	0.57216607
81	DAPK3	0.56442398
82	GSK3A	0.56399292
83	DYRK1B	0.56166274
84	ILK	0.55817073
85	PDPK1	0.55613838
86	CAMK2G	0.55601401
87	ADRBK2	0.55413763
88	SGK3	0.54862743
89	MAP3K10	0.54832515
90	ZAP70	0.54594797
91	TGFBR2	0.53857182
92	IKBKB	0.53650223
93	CAMK1	0.52377840
94	LRRK2	0.51903597
95	TTN	0.51851905
96	PTK2	0.51395308
97	RPS6KC1	0.51225908
98	RPS6KL1	0.51225908
99	MYLK	0.51108468
100	STK38	0.49462548
101	MAP2K6	0.49330103
102	TAOK2	0.49246928
103	MAP2K1	0.48745558
104	CDC42BPA	0.48127473
105	MAP3K14	0.45594409
106	STK3	0.45161110
107	TAOK1	0.44882821
108	CAMK1G	0.44771901
109	CDK4	0.43788499
110	RPS6KA6	0.43778531
111	CSK	0.43418484
112	MTOR	0.43343745
113	PRKG1	0.43081337
114	PAK3	0.40820760
115	MAPK15	0.40645998
116	OBSCN	0.40322809
117	SGK2	0.39500773
118	EIF2AK2	0.39188458
119	FGFR3	0.38665468
120	SCYL2	0.38356390
121	IGF1R	0.38345711
122	CSNK1G1	0.36696414
123	RET	0.36409584
124	MAPK7	0.36217974
125	CSF1R	0.34978222
126	PDK1	0.33683187
127	MAP3K13	0.30590230
128	PRKCQ	0.30001233
129	SGK494	0.28920955
130	SGK223	0.28920955
131	LMTK2	0.28769224
132	IKBKE	0.27244733
133	EPHA2	0.26256420
134	AKT3	0.25887836
135	KSR2	0.25285164
136	PRKD1	0.24920045
137	PDGFRA	0.21526118
138	GRK1	0.21283415
139	CAMK4	0.21128650

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary bile acid biosynthesis_Homo sapiens_hsa00120	4.19144048
2	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	3.31822525
3	Nitrogen metabolism_Homo sapiens_hsa00910	3.31654237
4	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	3.25607892
5	Arginine biosynthesis_Homo sapiens_hsa00220	2.94464708
6	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.74666916
7	Fatty acid degradation_Homo sapiens_hsa00071	2.68178599
8	Tryptophan metabolism_Homo sapiens_hsa00380	2.67133845
9	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.66267631
10	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.62932821
11	Complement and coagulation cascades_Homo sapiens_hsa04610	2.51726565
12	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.50209081
13	Propanoate metabolism_Homo sapiens_hsa00640	2.27780201
14	Butanoate metabolism_Homo sapiens_hsa00650	2.24581969
15	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.22641712
16	Peroxisome_Homo sapiens_hsa04146	2.12034109
17	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.09346670
18	Fatty acid metabolism_Homo sapiens_hsa01212	2.00396790
19	PPAR signaling pathway_Homo sapiens_hsa03320	1.97007585
20	Chemical carcinogenesis_Homo sapiens_hsa05204	1.90302736
21	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.88947686
22	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.82215343
23	Histidine metabolism_Homo sapiens_hsa00340	1.80965165
24	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.80093433
25	beta-Alanine metabolism_Homo sapiens_hsa00410	1.79304164
26	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.70938972
27	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.70159501
28	Caffeine metabolism_Homo sapiens_hsa00232	1.69272145
29	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.67102300
30	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.65759955
31	Retinol metabolism_Homo sapiens_hsa00830	1.61580504
32	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.58550796
33	Selenocompound metabolism_Homo sapiens_hsa00450	1.54795522
34	Pyruvate metabolism_Homo sapiens_hsa00620	1.53356081
35	Phenylalanine metabolism_Homo sapiens_hsa00360	1.51180028
36	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.47969712
37	Bile secretion_Homo sapiens_hsa04976	1.42991237
38	Tyrosine metabolism_Homo sapiens_hsa00350	1.40239003
39	Fatty acid elongation_Homo sapiens_hsa00062	1.37260146
40	Sulfur metabolism_Homo sapiens_hsa00920	1.35710868
41	Carbon metabolism_Homo sapiens_hsa01200	1.31451279
42	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.30499236
43	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.29179454
44	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.27444831
45	Folate biosynthesis_Homo sapiens_hsa00790	1.25965425
46	Fat digestion and absorption_Homo sapiens_hsa04975	1.18814388
47	ABC transporters_Homo sapiens_hsa02010	1.10341545
48	Steroid biosynthesis_Homo sapiens_hsa00100	1.09290915
49	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.04008116
50	Arginine and proline metabolism_Homo sapiens_hsa00330	1.03580962
51	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.03518544
52	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.97049581
53	Sulfur relay system_Homo sapiens_hsa04122	0.96883561
54	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.93715626
55	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.93581008
56	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.93040134
57	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.89471678
58	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.87696758
59	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.87402819
60	Lysine degradation_Homo sapiens_hsa00310	0.85427580
61	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.85239748
62	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.78591074
63	Glycerolipid metabolism_Homo sapiens_hsa00561	0.78003521
64	Glutathione metabolism_Homo sapiens_hsa00480	0.71041918
65	Other glycan degradation_Homo sapiens_hsa00511	0.70030707
66	One carbon pool by folate_Homo sapiens_hsa00670	0.69011129
67	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.68453719
68	Pentose phosphate pathway_Homo sapiens_hsa00030	0.63530120
69	Metabolic pathways_Homo sapiens_hsa01100	0.49663866
70	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.41469460
71	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.32242325
72	Galactose metabolism_Homo sapiens_hsa00052	0.31508483
73	Pertussis_Homo sapiens_hsa05133	0.30506886
74	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.30286706
75	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.28614929
76	Insulin resistance_Homo sapiens_hsa04931	0.28102472
77	Linoleic acid metabolism_Homo sapiens_hsa00591	0.27157469
78	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.21756817
79	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.21565816
80	Prion diseases_Homo sapiens_hsa05020	0.20353700
81	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.20172883
82	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.16190627
83	Glucagon signaling pathway_Homo sapiens_hsa04922	0.13665459
84	Mineral absorption_Homo sapiens_hsa04978	0.11756279
85	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.09992054
86	AMPK signaling pathway_Homo sapiens_hsa04152	0.09620686
87	Type II diabetes mellitus_Homo sapiens_hsa04930	0.04100712
88	Malaria_Homo sapiens_hsa05144	0.03373629
89	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.00148368
90	Amoebiasis_Homo sapiens_hsa05146	-0.2506934
91	Protein digestion and absorption_Homo sapiens_hsa04974	-0.2401913
92	African trypanosomiasis_Homo sapiens_hsa05143	-0.2366770
93	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	-0.2350282
94	Bladder cancer_Homo sapiens_hsa05219	-0.2323809
95	Circadian rhythm_Homo sapiens_hsa04710	-0.2251574
96	Hepatitis C_Homo sapiens_hsa05160	-0.2146940
97	Thyroid hormone synthesis_Homo sapiens_hsa04918	-0.2018166
98	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	-0.1841395
99	Renin-angiotensin system_Homo sapiens_hsa04614	-0.1787727
100	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	-0.1691583
101	Glycosaminoglycan degradation_Homo sapiens_hsa00531	-0.1674237
102	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	-0.1667026
103	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	-0.1628766
104	Central carbon metabolism in cancer_Homo sapiens_hsa05230	-0.1260094
105	Arachidonic acid metabolism_Homo sapiens_hsa00590	-0.1139331
106	Regulation of autophagy_Homo sapiens_hsa04140	-0.0798314
107	Cardiac muscle contraction_Homo sapiens_hsa04260	-0.0626866
108	Systemic lupus erythematosus_Homo sapiens_hsa05322	-0.0510940
109	Insulin signaling pathway_Homo sapiens_hsa04910	-0.0357768
110	Vascular smooth muscle contraction_Homo sapiens_hsa04270	-0.0187083
111	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	-0.0180205
112	Lysosome_Homo sapiens_hsa04142	-0.0094127

ECHDC3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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