ECHS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene functions in the second step of the mitochondrial fatty acid beta-oxidation pathway. It catalyzes the hydration of 2-trans-enoyl-coenzyme A (CoA) intermediates to L-3-hydroxyacyl-CoAs. The gene product is a member of the hydratase/isomerase superfamily. It localizes to the mitochondrial matrix. Transcript variants utilizing alternative transcription initiation sites have been described in the literature. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.47905565
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.47905565
3L-phenylalanine metabolic process (GO:0006558)6.21943528
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.21943528
5aromatic amino acid family catabolic process (GO:0009074)5.75413806
6glyoxylate metabolic process (GO:0046487)5.43200957
7indole-containing compound catabolic process (GO:0042436)5.16399729
8indolalkylamine catabolic process (GO:0046218)5.16399729
9tryptophan catabolic process (GO:0006569)5.16399729
10NADH metabolic process (GO:0006734)5.07225584
11triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.06563436
12kynurenine metabolic process (GO:0070189)5.00768278
13alpha-linolenic acid metabolic process (GO:0036109)4.91747331
14tryptophan metabolic process (GO:0006568)4.91561038
15lysine catabolic process (GO:0006554)4.87856255
16lysine metabolic process (GO:0006553)4.87856255
17bile acid biosynthetic process (GO:0006699)4.83263199
18fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.78617556
19regulation of triglyceride catabolic process (GO:0010896)4.77678632
20branched-chain amino acid catabolic process (GO:0009083)4.74044801
21* fatty acid beta-oxidation (GO:0006635)4.69401918
22amino-acid betaine metabolic process (GO:0006577)4.62123834
23mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.58179795
24sulfur amino acid catabolic process (GO:0000098)4.58117676
25cysteine metabolic process (GO:0006534)4.57857110
26short-chain fatty acid metabolic process (GO:0046459)4.48892724
27acetyl-CoA metabolic process (GO:0006084)4.48325419
28* fatty acid oxidation (GO:0019395)4.39638234
29cellular ketone body metabolic process (GO:0046950)4.37800116
30* lipid oxidation (GO:0034440)4.32665875
31valine metabolic process (GO:0006573)4.32524268
32* fatty acid catabolic process (GO:0009062)4.31829244
33homocysteine metabolic process (GO:0050667)4.29599361
34alpha-amino acid catabolic process (GO:1901606)4.28683872
35branched-chain amino acid metabolic process (GO:0009081)4.27657735
36serine family amino acid catabolic process (GO:0009071)4.26299074
37urea metabolic process (GO:0019627)4.25693873
38urea cycle (GO:0000050)4.25693873
39aromatic amino acid family metabolic process (GO:0009072)4.24175033
40oxaloacetate metabolic process (GO:0006107)4.21659411
41epoxygenase P450 pathway (GO:0019373)4.20885221
42complement activation, alternative pathway (GO:0006957)4.16907839
43regulation of sequestering of triglyceride (GO:0010889)4.16333819
44biotin metabolic process (GO:0006768)4.16287327
45fatty acid transmembrane transport (GO:1902001)4.12709925
46ethanol oxidation (GO:0006069)4.11871412
47* monocarboxylic acid catabolic process (GO:0072329)4.11460500
48high-density lipoprotein particle remodeling (GO:0034375)4.09648998
49tyrosine metabolic process (GO:0006570)4.09576213
50bile acid metabolic process (GO:0008206)4.08822835
51aspartate family amino acid catabolic process (GO:0009068)4.05873650
522-oxoglutarate metabolic process (GO:0006103)4.05258882
53cellular amino acid catabolic process (GO:0009063)4.05037394
54acylglycerol homeostasis (GO:0055090)4.04279981
55triglyceride homeostasis (GO:0070328)4.04279981
56nitrogen cycle metabolic process (GO:0071941)4.01866563
57carnitine metabolic process (GO:0009437)3.99510938
58coenzyme catabolic process (GO:0009109)3.98190924
59peptidyl-glutamic acid carboxylation (GO:0017187)3.97283750
60protein carboxylation (GO:0018214)3.97283750
61* carboxylic acid catabolic process (GO:0046395)3.93805682
62* organic acid catabolic process (GO:0016054)3.93805682
63regulation of fibrinolysis (GO:0051917)3.92725530
64carnitine shuttle (GO:0006853)3.90659593
65ATP synthesis coupled proton transport (GO:0015986)3.90139956
66energy coupled proton transport, down electrochemical gradient (GO:0015985)3.90139956
67cellular biogenic amine catabolic process (GO:0042402)3.88317157
68amine catabolic process (GO:0009310)3.88317157
69regulation of protein activation cascade (GO:2000257)3.88242720
70plasma lipoprotein particle clearance (GO:0034381)3.87165250
71negative regulation of fibrinolysis (GO:0051918)3.82395591
72regulation of cholesterol esterification (GO:0010872)3.82133745
73tricarboxylic acid cycle (GO:0006099)3.81054467
74plasma lipoprotein particle remodeling (GO:0034369)3.78800587
75protein-lipid complex remodeling (GO:0034368)3.78800587
76macromolecular complex remodeling (GO:0034367)3.78800587
77exogenous drug catabolic process (GO:0042738)3.78798738
78ketone body metabolic process (GO:1902224)3.78665496
79negative regulation of lipase activity (GO:0060192)3.76554580
80indolalkylamine metabolic process (GO:0006586)3.75808010
81L-serine metabolic process (GO:0006563)3.72301676
82aldehyde catabolic process (GO:0046185)3.71612923
83reverse cholesterol transport (GO:0043691)3.67109542
84respiratory electron transport chain (GO:0022904)3.63663297
85regulation of complement activation (GO:0030449)3.62211700
86benzene-containing compound metabolic process (GO:0042537)3.58838691
87positive regulation of fatty acid beta-oxidation (GO:0032000)3.58771755
88cellular glucuronidation (GO:0052695)3.58389068
89drug catabolic process (GO:0042737)3.57297358
90phospholipid homeostasis (GO:0055091)3.55688606
91cellular modified amino acid catabolic process (GO:0042219)3.55079315
92electron transport chain (GO:0022900)3.53832473
93acyl-CoA metabolic process (GO:0006637)3.52825679
94thioester metabolic process (GO:0035383)3.52825679
95glutamate metabolic process (GO:0006536)3.52584499
96polyketide metabolic process (GO:0030638)3.52303208
97doxorubicin metabolic process (GO:0044598)3.52303208
98daunorubicin metabolic process (GO:0044597)3.52303208
99protein maturation by protein folding (GO:0022417)3.51521418
100serine family amino acid metabolic process (GO:0009069)3.51037205
101omega-hydroxylase P450 pathway (GO:0097267)3.50429025
102positive regulation of lipid catabolic process (GO:0050996)3.45295621
103phospholipid efflux (GO:0033700)3.44956675
104gluconeogenesis (GO:0006094)3.44328711
105proteasome assembly (GO:0043248)3.42782613
106mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.41448047
107positive regulation of fatty acid oxidation (GO:0046321)3.39135007
108glycine metabolic process (GO:0006544)3.38779902
109uronic acid metabolic process (GO:0006063)3.37550393
110glucuronate metabolic process (GO:0019585)3.37550393
111regulation of cholesterol metabolic process (GO:0090181)3.36961294
112very long-chain fatty acid metabolic process (GO:0000038)3.33068462
113oxidative phosphorylation (GO:0006119)3.32720532
114dicarboxylic acid biosynthetic process (GO:0043650)3.32444869
115imidazole-containing compound metabolic process (GO:0052803)3.32160810
116serine family amino acid biosynthetic process (GO:0009070)3.31747924
117ethanol metabolic process (GO:0006067)3.31082219
118* small molecule catabolic process (GO:0044282)3.30859856
119monosaccharide biosynthetic process (GO:0046364)3.30562761
120hexose biosynthetic process (GO:0019319)3.28420395
121low-density lipoprotein particle remodeling (GO:0034374)3.27326876
122positive regulation of triglyceride lipase activity (GO:0061365)3.26147862
123positive regulation of lipoprotein lipase activity (GO:0051006)3.26147862
124regulation of mitochondrial translation (GO:0070129)3.25607454
125drug metabolic process (GO:0017144)3.25059831
126chaperone-mediated protein transport (GO:0072321)3.20495111
127aminoglycoside antibiotic metabolic process (GO:0030647)3.17008643
128proline biosynthetic process (GO:0006561)3.16726221
129regulation of cellular amino acid metabolic process (GO:0006521)3.16638109
130proline metabolic process (GO:0006560)3.11192536
131fibrinolysis (GO:0042730)3.08346296
132establishment of protein localization to mitochondrial membrane (GO:0090151)3.02852561
133fructose metabolic process (GO:0006000)3.01382801
134negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.97446185
135primary alcohol catabolic process (GO:0034310)2.95888792
136cellular aldehyde metabolic process (GO:0006081)2.88543462
137xenobiotic catabolic process (GO:0042178)2.87051603
138amino acid salvage (GO:0043102)2.83648642
139L-methionine salvage (GO:0071267)2.83648642
140L-methionine biosynthetic process (GO:0071265)2.83648642
141arginine metabolic process (GO:0006525)2.80214549
142phenylpropanoid metabolic process (GO:0009698)2.78510468
143negative regulation of ligase activity (GO:0051352)2.77036780
144negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.77036780
145positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.75832429
146quinone metabolic process (GO:1901661)2.73158045
147tricarboxylic acid metabolic process (GO:0072350)2.71616571
148blood coagulation, intrinsic pathway (GO:0007597)2.70967320
149NADPH regeneration (GO:0006740)2.70069179
150regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.70068734
151aerobic respiration (GO:0009060)2.68842702
152glutamine family amino acid biosynthetic process (GO:0009084)2.59666882
153ribosomal small subunit assembly (GO:0000028)2.59505394
154nucleobase-containing small molecule interconversion (GO:0015949)2.59460813

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.76333880
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.43987559
3RXR_22158963_ChIP-Seq_LIVER_Mouse6.84171236
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.93187108
5PPARA_22158963_ChIP-Seq_LIVER_Mouse5.82656590
6LXR_22158963_ChIP-Seq_LIVER_Mouse5.44247889
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.48704154
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.24357891
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.66591658
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.61035256
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.50766895
12MYC_18555785_ChIP-Seq_MESCs_Mouse3.29018106
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.26303723
14CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.24551302
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.03835126
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.95903480
17* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.92576300
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.75459958
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.75314870
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.71753713
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.70501184
22ETS1_20019798_ChIP-Seq_JURKAT_Human2.41421923
23EST1_17652178_ChIP-ChIP_JURKAT_Human2.28935087
24* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.23381707
25PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.22266215
26MYC_19030024_ChIP-ChIP_MESCs_Mouse2.18462028
27THAP11_20581084_ChIP-Seq_MESCs_Mouse2.13715528
28ZNF263_19887448_ChIP-Seq_K562_Human2.09128427
29MYC_19079543_ChIP-ChIP_MESCs_Mouse2.04782255
30XRN2_22483619_ChIP-Seq_HELA_Human2.00108822
31NELFA_20434984_ChIP-Seq_ESCs_Mouse1.99041925
32DCP1A_22483619_ChIP-Seq_HELA_Human1.91715181
33CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.90607833
34HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.87525629
35ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.82798590
36GABP_19822575_ChIP-Seq_HepG2_Human1.71219885
37PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.70902340
38ZFX_18555785_ChIP-Seq_MESCs_Mouse1.70880136
39TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.70178579
40CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.64805414
41HTT_18923047_ChIP-ChIP_STHdh_Human1.63322850
42AR_21909140_ChIP-Seq_LNCAP_Human1.57543723
43POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.55935907
44E2F7_22180533_ChIP-Seq_HELA_Human1.52894714
45ESR1_15608294_ChIP-ChIP_MCF-7_Human1.52329193
46TTF2_22483619_ChIP-Seq_HELA_Human1.47934929
47ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.47684406
48CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.47633121
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.45872908
50STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.44521120
51MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.43433463
52E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.42297147
53HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.39967140
54ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.39186950
55ELF1_17652178_ChIP-ChIP_JURKAT_Human1.36148269
56TET1_21451524_ChIP-Seq_MESCs_Mouse1.35019689
57CLOCK_20551151_ChIP-Seq_293T_Human1.32330061
58NANOG_18555785_ChIP-Seq_MESCs_Mouse1.31418875
59PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.30511265
60FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.29601278
61CTCF_18555785_ChIP-Seq_MESCs_Mouse1.29492605
62SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.28548059
63MYCN_18555785_ChIP-Seq_MESCs_Mouse1.27970723
64SRY_22984422_ChIP-ChIP_TESTIS_Rat1.27839197
65FOXA2_19822575_ChIP-Seq_HepG2_Human1.26077501
66STAT3_1855785_ChIP-Seq_MESCs_Mouse1.25509616
67POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.24964947
68BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.24745016
69OCT4_18692474_ChIP-Seq_MEFs_Mouse1.24353599
70DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.24075945
71FOXP3_21729870_ChIP-Seq_TREG_Human1.22772579
72TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17272586
73* HNF4A_19822575_ChIP-Seq_HepG2_Human1.12868500
74CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.10982231
75ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.09648474
76POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.09332462
77GATA1_22025678_ChIP-Seq_K562_Human1.08369194
78SOX2_18692474_ChIP-Seq_MEFs_Mouse1.08100001
79* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08023911
80KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07354528
81* TBX5_21415370_ChIP-Seq_HL-1_Mouse1.05238518
82DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.05174213
83SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.04423908
84HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.02408988
85KDM5A_27292631_Chip-Seq_BREAST_Human1.02119932
86VDR_23849224_ChIP-Seq_CD4+_Human1.01941779
87AUTS2_25519132_ChIP-Seq_293T-REX_Human1.01410327
88FOXP1_21924763_ChIP-Seq_HESCs_Human1.00055196
89* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.99761573
90EP300_21415370_ChIP-Seq_HL-1_Mouse0.99155048
91RACK7_27058665_Chip-Seq_MCF-7_Human0.99094370
92* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98393425
93ESR1_20079471_ChIP-ChIP_T-47D_Human0.97925296
94TAF15_26573619_Chip-Seq_HEK293_Human0.97859860
95PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.95521696
96* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.95442203
97SUZ12_27294783_Chip-Seq_NPCs_Mouse0.95241562
98PCGF2_27294783_Chip-Seq_NPCs_Mouse0.95138659
99BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94355039
100CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.94093493
101TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.93377827
102PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92870191
103* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.92377206
104SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.91681329
105EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.91644599
106NFE2_27457419_Chip-Seq_LIVER_Mouse0.91352969
107CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90724040
108KAP1_22055183_ChIP-Seq_ESCs_Mouse0.90658625
109LXR_22292898_ChIP-Seq_THP-1_Human0.90093429
110SOX17_20123909_ChIP-Seq_XEN_Mouse0.89191206
111PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.88785284
112EOMES_21245162_ChIP-Seq_HESCs_Human0.88731140
113TRIM28_21343339_ChIP-Seq_HEK293_Human0.88712818
114CDX2_19796622_ChIP-Seq_MESCs_Mouse0.88526502
115ERG_20887958_ChIP-Seq_HPC-7_Mouse0.87937154
116PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.87197965
117RXRA_24833708_ChIP-Seq_LIVER_Mouse0.87022470
118EZH2_27294783_Chip-Seq_NPCs_Mouse0.86975783
119RARG_19884340_ChIP-ChIP_MEFs_Mouse0.84639268
120CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.84497488
121GATA4_25053715_ChIP-Seq_YYC3_Human0.84292079
122PIAS1_25552417_ChIP-Seq_VCAP_Human0.82933760
123TBX20_22328084_ChIP-Seq_HEART_Mouse0.81232244
124TBX20_22080862_ChIP-Seq_HEART_Mouse0.81232244
125BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.80455713
126* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.80424120
127PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.78793901
128AR_20517297_ChIP-Seq_VCAP_Human0.77632525
129RAD21_21589869_ChIP-Seq_MESCs_Mouse0.77009896
130GBX2_23144817_ChIP-Seq_PC3_Human0.76866453
131CRX_20693478_ChIP-Seq_RETINA_Mouse0.76273912
132GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76260053
133SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.75234440
134CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.74832842
135BCAT_22108803_ChIP-Seq_LS180_Human0.74702248
136STAT1_17558387_ChIP-Seq_HELA_Human0.73584938
137ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.73240650
138NRF2_20460467_ChIP-Seq_MEFs_Mouse0.72358066
139NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.72358066
140THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.71326927
141PCGF2_27294783_Chip-Seq_ESCs_Mouse0.70509428
142PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.69913485
143CBP_21632823_ChIP-Seq_H3396_Human0.69268002
144OCT4_21477851_ChIP-Seq_ESCs_Mouse0.68998428
145AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.68813255
146CEBPB_22108803_ChIP-Seq_LS180_Human0.68297705
147SOX2_27498859_Chip-Seq_STOMACH_Mouse0.67881550
148IRF1_19129219_ChIP-ChIP_H3396_Human0.67406364
149RUNX1_27457419_Chip-Seq_LIVER_Mouse0.67270066
150CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.66193400
151VDR_22108803_ChIP-Seq_LS180_Human0.64390506
152ESET_19884257_ChIP-Seq_ESCs_Mouse0.63920573
153ESR2_21235772_ChIP-Seq_MCF-7_Human0.62689989
154PPAR_26484153_Chip-Seq_NCI-H1993_Human0.62608057
155UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.61563691
156CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.61289066
157GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.61187256
158ZFP57_27257070_Chip-Seq_ESCs_Mouse0.60953389
159ERG_20517297_ChIP-Seq_VCAP_Human0.60117148
160NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.59537007
161LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.59222202
162EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.57933148
163ESR1_21235772_ChIP-Seq_MCF-7_Human0.57932962
164SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.57318318
165PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.56289756
166FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.56123860
167OCT4_18555785_Chip-Seq_ESCs_Mouse0.55812888
168SMAD1_18555785_Chip-Seq_ESCs_Mouse0.55752038
169FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.55086801
170TAL1_26923725_Chip-Seq_HPCs_Mouse0.54615805
171SALL4_18804426_ChIP-ChIP_XEN_Mouse0.53929400
172HNFA_21074721_ChIP-Seq_CACO-2_Human0.53854079
173SUZ12_18555785_Chip-Seq_ESCs_Mouse0.53320679
174ESRRB_18555785_Chip-Seq_ESCs_Mouse0.52322995
175ZFX_18555785_Chip-Seq_ESCs_Mouse0.52110597
176ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.51977280
177EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.51713462
178SRF_21415370_ChIP-Seq_HL-1_Mouse0.51394538

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.74721867
2MP0005360_urolithiasis6.39781221
3MP0005085_abnormal_gallbladder_physiolo5.46546990
4MP0005365_abnormal_bile_salt5.29979794
5MP0008875_abnormal_xenobiotic_pharmacok4.26734054
6MP0003806_abnormal_nucleotide_metabolis3.83332774
7MP0010329_abnormal_lipoprotein_level3.19310133
8MP0003252_abnormal_bile_duct3.07551788
9MP0005332_abnormal_amino_acid2.93633366
10MP0003195_calcinosis2.88871299
11MP0002837_dystrophic_cardiac_calcinosis2.79314795
12MP0005083_abnormal_biliary_tract2.73383016
13MP0005670_abnormal_white_adipose2.63802686
14MP0005451_abnormal_body_composition2.34797392
15MP0009840_abnormal_foam_cell2.33161980
16MP0001666_abnormal_nutrient_absorption2.27640426
17MP0002118_abnormal_lipid_homeostasis2.20882611
18MP0004019_abnormal_vitamin_homeostasis2.16868442
19MP0009379_abnormal_foot_pigmentation2.01850892
20MP0004130_abnormal_muscle_cell1.95709877
21MP0003191_abnormal_cellular_cholesterol1.92658799
22MP0010030_abnormal_orbit_morphology1.83868069
23MP0005666_abnormal_adipose_tissue1.81775837
24MP0000609_abnormal_liver_physiology1.79589228
25MP0006036_abnormal_mitochondrial_physio1.74124820
26MP0003693_abnormal_embryo_hatching1.70933325
27MP0003011_delayed_dark_adaptation1.70461044
28MP0003646_muscle_fatigue1.70408556
29MP0003186_abnormal_redox_activity1.68349220
30MP0005319_abnormal_enzyme/_coenzyme1.67586014
31MP0005584_abnormal_enzyme/coenzyme_acti1.58325397
32MP0001764_abnormal_homeostasis1.56309828
33MP0005058_abnormal_lysosome_morphology1.55210482
34MP0002138_abnormal_hepatobiliary_system1.46374748
35MP0005330_cardiomyopathy1.43146272
36MP0009697_abnormal_copulation1.42512804
37MP0002971_abnormal_brown_adipose1.41895443
38MP0009643_abnormal_urine_homeostasis1.38894537
39MP0003868_abnormal_feces_composition1.32338206
40MP0004957_abnormal_blastocyst_morpholog1.31226406
41MP0003941_abnormal_skin_development1.27362704
42MP0001661_extended_life_span1.25933171
43MP0000566_synostosis1.23159084
44MP0004215_abnormal_myocardial_fiber1.19975807
45MP0005647_abnormal_sex_gland1.16881799
46MP0008932_abnormal_embryonic_tissue1.10823582
47MP0005535_abnormal_body_temperature1.09478341
48MP0003123_paternal_imprinting1.07807594
49MP0002876_abnormal_thyroid_physiology1.07691276
50MP0010234_abnormal_vibrissa_follicle1.07019914
51MP0000747_muscle_weakness1.06461172
52MP0005334_abnormal_fat_pad1.04318204
53MP0004043_abnormal_pH_regulation1.03752588
54MP0004036_abnormal_muscle_relaxation1.02615162
55MP0004185_abnormal_adipocyte_glucose1.02461791
56MP0000751_myopathy1.00404902
57MP0004084_abnormal_cardiac_muscle1.00314277
58MP0001881_abnormal_mammary_gland0.97833825
59MP0002254_reproductive_system_inflammat0.97549560
60MP0004381_abnormal_hair_follicle0.97142745
61MP0005636_abnormal_mineral_homeostasis0.92616578
62MP0009763_increased_sensitivity_to0.92582160
63MP0005375_adipose_tissue_phenotype0.91263904
64MP0006035_abnormal_mitochondrial_morpho0.90727398
65MP0001727_abnormal_embryo_implantation0.89992134
66MP0002078_abnormal_glucose_homeostasis0.89705999
67MP0003690_abnormal_glial_cell0.86803692
68MP0003315_abnormal_perineum_morphology0.85977706
69MP0000749_muscle_degeneration0.85637464
70MP0004233_abnormal_muscle_weight0.84782729
71MP0006138_congestive_heart_failure0.84433052
72MP0002972_abnormal_cardiac_muscle0.84045105
73MP0002938_white_spotting0.83984575
74MP0005266_abnormal_metabolism0.83162823
75MP0009672_abnormal_birth_weight0.82692378
76MP0002132_abnormal_respiratory_system0.82627490
77MP0009764_decreased_sensitivity_to0.82503405
78MP0001544_abnormal_cardiovascular_syste0.82292766
79MP0005385_cardiovascular_system_phenoty0.82292766
80MP0000538_abnormal_urinary_bladder0.80778210
81MP0009053_abnormal_anal_canal0.79705286
82MP0000598_abnormal_liver_morphology0.79450909
83MP0005376_homeostasis/metabolism_phenot0.79417997
84MP0005620_abnormal_muscle_contractility0.78816927
85MP0009642_abnormal_blood_homeostasis0.77916050
86MP0008058_abnormal_DNA_repair0.76538526
87MP0008775_abnormal_heart_ventricle0.75859801
88MP0003137_abnormal_impulse_conducting0.74913327
89MP0009115_abnormal_fat_cell0.74242504
90MP0000230_abnormal_systemic_arterial0.74070285
91MP0005448_abnormal_energy_balance0.73040267
92MP0001756_abnormal_urination0.72360847
93MP0010368_abnormal_lymphatic_system0.72119667
94MP0000358_abnormal_cell_content/0.71711520
95MP0002090_abnormal_vision0.71506844
96MP0004147_increased_porphyrin_level0.71302651
97MP0002332_abnormal_exercise_endurance0.71203182
98MP0005408_hypopigmentation0.71165155
99MP0001529_abnormal_vocalization0.71091146
100MP0003111_abnormal_nucleus_morphology0.70913739
101MP0000537_abnormal_urethra_morphology0.70618449
102MP0003656_abnormal_erythrocyte_physiolo0.68618522
103MP0008007_abnormal_cellular_replicative0.68368220
104MP0005501_abnormal_skin_physiology0.68119480
105MP0004087_abnormal_muscle_fiber0.66978895
106MP0008789_abnormal_olfactory_epithelium0.66547931
107MP0003724_increased_susceptibility_to0.65570359
108MP0003077_abnormal_cell_cycle0.65452055
109MP0002269_muscular_atrophy0.64836760
110MP0008872_abnormal_physiological_respon0.64422897
111MP0001905_abnormal_dopamine_level0.64296742
112MP0003950_abnormal_plasma_membrane0.64017239
113MP0005084_abnormal_gallbladder_morpholo0.63831446
114MP0000750_abnormal_muscle_regeneration0.63731096
115MP0003786_premature_aging0.63587777
116MP0000003_abnormal_adipose_tissue0.63307312
117MP0008469_abnormal_protein_level0.62794973
118MP0000467_abnormal_esophagus_morphology0.61953820
119MP0000372_irregular_coat_pigmentation0.60488065
120MP0002970_abnormal_white_adipose0.60404596
121MP0000759_abnormal_skeletal_muscle0.60172175
122MP0000579_abnormal_nail_morphology0.59074162
123MP0004145_abnormal_muscle_electrophysio0.58498174
124MP0005165_increased_susceptibility_to0.57339502
125MP0010630_abnormal_cardiac_muscle0.57126985
126MP0009765_abnormal_xenobiotic_induced0.56672422
127MP0002909_abnormal_adrenal_gland0.54995692
128MP0001730_embryonic_growth_arrest0.54904567
129MP0000604_amyloidosis0.53707885
130MP0004272_abnormal_basement_membrane0.52970371
131MP0003959_abnormal_lean_body0.52772085
132MP0003221_abnormal_cardiomyocyte_apopto0.52572378
133MP0005395_other_phenotype0.51781535
134MP0003953_abnormal_hormone_level0.50797006
135MP0003718_maternal_effect0.49994771
136MP0005452_abnormal_adipose_tissue0.49104312
137MP0002136_abnormal_kidney_physiology0.49080741
138MP0009384_cardiac_valve_regurgitation0.47727966
139MP0004085_abnormal_heartbeat0.46983124
140MP0002796_impaired_skin_barrier0.43952330
141MP0005220_abnormal_exocrine_pancreas0.42550039

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.56861354
2Intrahepatic cholestasis (HP:0001406)5.44475667
3Hyperglycinuria (HP:0003108)5.16811774
4Deep venous thrombosis (HP:0002625)4.83615710
5Prolonged partial thromboplastin time (HP:0003645)4.81553920
6Abnormality of glycine metabolism (HP:0010895)4.80299415
7Abnormality of serine family amino acid metabolism (HP:0010894)4.80299415
8Xanthomatosis (HP:0000991)4.79773627
9Hyperammonemia (HP:0001987)4.70776189
10Abnormality of fatty-acid metabolism (HP:0004359)4.67735644
11Hypoglycemic coma (HP:0001325)4.62775663
12Ketosis (HP:0001946)4.61091909
13Hyperlipoproteinemia (HP:0010980)4.52088962
14Abnormality of monocarboxylic acid metabolism (HP:0010996)4.50497580
15Hypobetalipoproteinemia (HP:0003563)4.30898704
16Hyperglycinemia (HP:0002154)4.25473790
17Abnormality of dicarboxylic acid metabolism (HP:0010995)4.13116483
18Dicarboxylic aciduria (HP:0003215)4.13116483
19Ketoacidosis (HP:0001993)3.97801970
20Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.92120687
21Cerebral edema (HP:0002181)3.90754739
22Hypoalphalipoproteinemia (HP:0003233)3.79176157
23Hypolipoproteinemia (HP:0010981)3.79048262
24Abnormality of aspartate family amino acid metabolism (HP:0010899)3.75571545
25Complement deficiency (HP:0004431)3.74292498
26Joint hemorrhage (HP:0005261)3.67120414
27Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.63587543
28Epidermoid cyst (HP:0200040)3.62135276
29Abnormality of glutamine family amino acid metabolism (HP:0010902)3.61675903
30Abnormality of methionine metabolism (HP:0010901)3.49682407
31Lethargy (HP:0001254)3.36310531
32Generalized aminoaciduria (HP:0002909)3.33394652
33Renal cortical cysts (HP:0000803)3.31848431
34Hepatic necrosis (HP:0002605)3.29306654
35Reduced antithrombin III activity (HP:0001976)3.24882368
36Abnormality of sulfur amino acid metabolism (HP:0004339)3.23449068
37Metabolic acidosis (HP:0001942)3.21681082
38Abnormality of serum amino acid levels (HP:0003112)3.20657520
39Fat malabsorption (HP:0002630)3.08240335
40Proximal tubulopathy (HP:0000114)3.08053431
41Acute encephalopathy (HP:0006846)3.05046331
42Conjugated hyperbilirubinemia (HP:0002908)3.02561042
43Myoglobinuria (HP:0002913)3.01574853
44Systemic lupus erythematosus (HP:0002725)2.97754420
45Abnormality of pyrimidine metabolism (HP:0004353)2.93063996
46Cholecystitis (HP:0001082)2.92779057
47Abnormal gallbladder physiology (HP:0012438)2.92779057
48Abnormality of the common coagulation pathway (HP:0010990)2.89990685
49Delayed CNS myelination (HP:0002188)2.86270015
50Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.83543187
51Decreased activity of mitochondrial respiratory chain (HP:0008972)2.83543187
52Exercise intolerance (HP:0003546)2.81080836
53Increased hepatocellular lipid droplets (HP:0006565)2.75611359
54Renal Fanconi syndrome (HP:0001994)2.75399102
55Hypercholesterolemia (HP:0003124)2.75080920
56Vomiting (HP:0002013)2.72476997
57Abnormality of glycolysis (HP:0004366)2.71337267
58Increased serum pyruvate (HP:0003542)2.71337267
59Abnormality of nucleobase metabolism (HP:0010932)2.69645205
60Nausea (HP:0002018)2.67656231
61Rhabdomyolysis (HP:0003201)2.64515227
62Microvesicular hepatic steatosis (HP:0001414)2.62369519
63Increased serum lactate (HP:0002151)2.60342141
64Increased muscle lipid content (HP:0009058)2.59355360
65Abnormality of purine metabolism (HP:0004352)2.57935810
66Hyperbilirubinemia (HP:0002904)2.56883800
67Respiratory failure (HP:0002878)2.55336023
68Hyperphosphaturia (HP:0003109)2.54640822
69Abnormality of urine glucose concentration (HP:0011016)2.53569918
70Glycosuria (HP:0003076)2.53569918
71Abnormality of complement system (HP:0005339)2.53505872
72Abnormality of the intrinsic pathway (HP:0010989)2.51104239
73Steatorrhea (HP:0002570)2.44906192
74Hepatocellular necrosis (HP:0001404)2.44808876
75Abnormal mitochondria in muscle tissue (HP:0008316)2.43905932
76Acute necrotizing encephalopathy (HP:0006965)2.43259075
77Type I transferrin isoform profile (HP:0003642)2.37710667
78Ragged-red muscle fibers (HP:0003200)2.36338320
79Lactic acidosis (HP:0003128)2.34704640
80Vascular calcification (HP:0004934)2.34547668
81Skin nodule (HP:0200036)2.34011896
82Pancreatitis (HP:0001733)2.28809396
83Hypoglycemic seizures (HP:0002173)2.28552307
84CNS demyelination (HP:0007305)2.27073794
85Abnormality of proline metabolism (HP:0010907)2.22905800
86Hydroxyprolinuria (HP:0003080)2.22905800
87Gout (HP:0001997)2.21511373
88Methylmalonic aciduria (HP:0012120)2.20727060
89Enlarged kidneys (HP:0000105)2.20450150
90Hyperinsulinemic hypoglycemia (HP:0000825)2.19912612
91Palpitations (HP:0001962)2.12031492
92Macrocytic anemia (HP:0001972)2.11197363
93Hypertriglyceridemia (HP:0002155)2.08305700
94Multiple enchondromatosis (HP:0005701)2.08000759
95Ventricular tachycardia (HP:0004756)2.07938255
96Mitochondrial inheritance (HP:0001427)2.07823674
97Opisthotonus (HP:0002179)2.07354972
98Increased purine levels (HP:0004368)2.07242347
99Hyperuricemia (HP:0002149)2.07242347
100Cerebral palsy (HP:0100021)2.06715330
101Increased CSF lactate (HP:0002490)2.06164146
102Sudden death (HP:0001699)2.05545235
103Cardiovascular calcification (HP:0011915)2.05269516
104Abnormal gallbladder morphology (HP:0012437)2.05103271
105Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.04103300
106Right ventricular cardiomyopathy (HP:0011663)2.04008448
107Nemaline bodies (HP:0003798)2.03933838
108Exercise-induced myalgia (HP:0003738)2.03928136
109Cholelithiasis (HP:0001081)2.03233708
110Progressive macrocephaly (HP:0004481)2.01376641
111Methylmalonic acidemia (HP:0002912)2.00323644
112Myocardial infarction (HP:0001658)1.99823950
113Abnormal urine phosphate concentration (HP:0012599)1.99779676
114Increased intramyocellular lipid droplets (HP:0012240)1.97314516
115Respiratory distress (HP:0002098)1.96842765
116Brushfield spots (HP:0001088)1.95074544
117Hepatocellular carcinoma (HP:0001402)1.93811924
118Testicular atrophy (HP:0000029)1.92477699
119Lipid accumulation in hepatocytes (HP:0006561)1.88227611
120Hypophosphatemic rickets (HP:0004912)1.86337834
121Neonatal onset (HP:0003623)1.86033778
122Megaloblastic anemia (HP:0001889)1.85230520
123Renal tubular dysfunction (HP:0000124)1.84827198
124Glomerulonephritis (HP:0000099)1.84813462
125Elevated hepatic transaminases (HP:0002910)1.84487813
126Muscle fiber inclusion bodies (HP:0100299)1.83929895
127Progressive muscle weakness (HP:0003323)1.83832924
128Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.83485645
129Distal lower limb muscle weakness (HP:0009053)1.82772317
130Abnormality of vitamin metabolism (HP:0100508)1.82262175
131Exercise-induced muscle cramps (HP:0003710)1.80483610

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.17508853
2VRK24.80977662
3BUB13.33088500
4INSRR3.23484399
5TESK13.21692126
6SIK13.04502936
7NEK12.74077551
8LIMK12.47855779
9OBSCN2.41742880
10PDK42.32024834
11PDK32.32024834
12LMTK22.28253420
13EPHA22.24482169
14MAP3K122.24313576
15TIE12.16779391
16MYLK2.15857495
17FGFR42.15304246
18STK162.02407290
19PHKG21.90715910
20PHKG11.90715910
21NME11.82650575
22TESK21.80591136
23EIF2AK11.77997225
24MST1R1.77852241
25PRKAA21.75263631
26ARAF1.74676930
27CAMK1D1.74523707
28WNK41.72805085
29ERBB41.72758115
30PIM21.72096837
31STK38L1.70934547
32PDK21.68089315
33STK391.66980772
34TTN1.65921614
35PIK3CG1.64558525
36SMG11.64110575
37PAK41.63866949
38PINK11.61384047
39SCYL21.57252156
40PIK3CA1.52526120
41SRPK11.51392632
42IRAK31.50699889
43LATS11.49486204
44GRK71.47833583
45ERN11.45632088
46PKN11.42786815
47EIF2AK21.37930525
48PBK1.32637899
49TSSK61.30734485
50VRK11.29275562
51ILK1.27200813
52MUSK1.25904457
53DAPK11.24504338
54MST41.21190030
55ZAK1.17844373
56MAPKAPK31.17749249
57GRK11.14654080
58DAPK31.14077940
59OXSR11.11915969
60FGFR21.09652310
61MAPK121.08310825
62EPHB11.07907980
63CAMK1G1.07881649
64TAOK31.07232548
65FLT31.01728963
66MAPK111.00526041
67TAF10.99771542
68NEK90.97140176
69MAP3K70.94822996
70LRRK20.93123484
71BRSK10.89158190
72ABL20.88167030
73AURKA0.82985243
74RPS6KB20.82842908
75PRKAA10.82684092
76CDK80.81661270
77CSNK1G30.80149744
78CAMK2G0.78928375
79TRIM280.78680228
80AURKB0.78125076
81PLK30.78016535
82CASK0.76748095
83PLK10.76010456
84EIF2AK30.75644862
85MAP3K110.74424017
86WNK30.72125689
87CAMK2D0.70105148
88SGK2230.69737422
89SGK4940.69737422
90PRKD30.69521751
91CDK70.69007611
92CDC70.68547224
93PKN20.68263469
94MAP2K40.68092523
95MET0.68022698
96PRKACG0.67095793
97IRAK20.66734351
98KDR0.62382197
99STK240.61039108
100FRK0.60901664
101PRKCI0.57978484
102IRAK10.57692916
103BRAF0.57035189
104STK40.57015432
105MAPK150.55986304
106CSNK2A20.54320967
107MAPK70.54314452
108MAPK40.54239325
109DYRK20.54101703
110NUAK10.54002684
111PRKD10.53381329
112PAK10.53214896
113MAP2K30.53068728
114TGFBR20.52659282
115PRKACA0.52596809
116MAP3K140.51277730
117MAP4K20.51075016
118WEE10.50529941
119GSK3A0.50390898
120ADRBK20.50238575
121TAOK20.50015628
122CSNK2A10.49801990
123PRKCQ0.48965963
124BMPR1B0.46018901
125TYK20.44924511
126JAK10.44860764
127PDPK10.44342575
128MAP2K70.44052955
129PRKG20.43523669
130PTK20.43050190
131TRIB30.43048388
132ERBB20.43033196
133CSNK1G20.43031498
134EPHB20.42061486
135CAMK40.41804161
136SGK20.41473372
137MAP3K30.39889277
138CDK11A0.39594398
139EPHA30.39392059
140CSNK1A1L0.39184154
141CDK180.38949522
142PRKCE0.38576564
143CDK150.38178097
144CDK140.38118111
145CSNK1G10.37596778
146PRKACB0.37228168
147JAK20.37053535
148IGF1R0.36719018
149FER0.36169593
150CAMK2A0.35766205
151NME20.35716519
152MAP3K80.35170208
153PTK60.34947467
154PAK30.33280795
155TTK0.33255425
156LATS20.32856837
157MAP3K60.32027585
158MAPKAPK50.31928068
159PRKCZ0.31719996
160MAP2K60.30136953
161NEK60.29347461
162AKT20.29203372
163ATR0.27944209
164CHEK20.27926735
165CDK90.27242281
166MAP3K90.27217605
167TLK10.26162494

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.33325813
2* Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.17861549
3* Propanoate metabolism_Homo sapiens_hsa006403.07330501
4* Fatty acid degradation_Homo sapiens_hsa000713.04847658
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.68848243
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.60339488
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.56530255
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.53090867
9* Fatty acid metabolism_Homo sapiens_hsa012122.51812360
10* Tryptophan metabolism_Homo sapiens_hsa003802.48262788
11Proteasome_Homo sapiens_hsa030502.48159564
12Nitrogen metabolism_Homo sapiens_hsa009102.44742755
13* Butanoate metabolism_Homo sapiens_hsa006502.33612754
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.32836588
15Arginine biosynthesis_Homo sapiens_hsa002202.29010720
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.25654467
17Peroxisome_Homo sapiens_hsa041462.22137855
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.20342610
19PPAR signaling pathway_Homo sapiens_hsa033202.15856041
20* Fatty acid elongation_Homo sapiens_hsa000622.13921250
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.07985196
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.98945910
23* beta-Alanine metabolism_Homo sapiens_hsa004101.94202215
24Pentose and glucuronate interconversions_Homo sapiens_hsa000401.94032545
25Complement and coagulation cascades_Homo sapiens_hsa046101.92403006
26Pyruvate metabolism_Homo sapiens_hsa006201.87589895
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.80062885
28Histidine metabolism_Homo sapiens_hsa003401.78945502
29Ribosome_Homo sapiens_hsa030101.73882293
30Chemical carcinogenesis_Homo sapiens_hsa052041.72889645
31Steroid hormone biosynthesis_Homo sapiens_hsa001401.72070836
32Phenylalanine metabolism_Homo sapiens_hsa003601.63034698
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.62428062
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.60251524
35* Carbon metabolism_Homo sapiens_hsa012001.57452341
36Retinol metabolism_Homo sapiens_hsa008301.54193095
37Tyrosine metabolism_Homo sapiens_hsa003501.50836215
38Sulfur metabolism_Homo sapiens_hsa009201.37741632
39Caffeine metabolism_Homo sapiens_hsa002321.34840245
40Drug metabolism - other enzymes_Homo sapiens_hsa009831.29678357
41Starch and sucrose metabolism_Homo sapiens_hsa005001.29079738
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.28782541
43Steroid biosynthesis_Homo sapiens_hsa001001.26493947
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.18870373
45Fat digestion and absorption_Homo sapiens_hsa049751.18405616
46Staphylococcus aureus infection_Homo sapiens_hsa051501.18126522
47Fatty acid biosynthesis_Homo sapiens_hsa000611.17603388
48DNA replication_Homo sapiens_hsa030301.15251023
49Biosynthesis of amino acids_Homo sapiens_hsa012301.13926550
50Arginine and proline metabolism_Homo sapiens_hsa003301.10667022
51Folate biosynthesis_Homo sapiens_hsa007901.07963984
52Selenocompound metabolism_Homo sapiens_hsa004501.07519166
53RNA polymerase_Homo sapiens_hsa030201.07415317
54Cysteine and methionine metabolism_Homo sapiens_hsa002701.07184058
55Bile secretion_Homo sapiens_hsa049761.06187044
56Oxidative phosphorylation_Homo sapiens_hsa001901.06042130
57ABC transporters_Homo sapiens_hsa020101.05296332
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.00937408
59Glycerolipid metabolism_Homo sapiens_hsa005610.95680646
60Glutathione metabolism_Homo sapiens_hsa004800.94547037
61Base excision repair_Homo sapiens_hsa034100.93963180
62Vitamin digestion and absorption_Homo sapiens_hsa049770.93148416
63Pyrimidine metabolism_Homo sapiens_hsa002400.92476769
64Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.92371672
65Mismatch repair_Homo sapiens_hsa034300.91777059
66Vitamin B6 metabolism_Homo sapiens_hsa007500.89780869
67Parkinsons disease_Homo sapiens_hsa050120.87084849
68Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.84909845
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84529077
70Sulfur relay system_Homo sapiens_hsa041220.81905821
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.80701174
72* Lysine degradation_Homo sapiens_hsa003100.77961613
73Protein export_Homo sapiens_hsa030600.76103160
74Cyanoamino acid metabolism_Homo sapiens_hsa004600.73903920
75Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.73619875
76* Metabolic pathways_Homo sapiens_hsa011000.69124682
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.68910379
78Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.61097151
79Alzheimers disease_Homo sapiens_hsa050100.58926349
80Maturity onset diabetes of the young_Homo sapiens_hsa049500.55157785
81Pentose phosphate pathway_Homo sapiens_hsa000300.54661373
82alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54085438
83Nucleotide excision repair_Homo sapiens_hsa034200.49317711
84Linoleic acid metabolism_Homo sapiens_hsa005910.49094337
85Purine metabolism_Homo sapiens_hsa002300.48967957
86One carbon pool by folate_Homo sapiens_hsa006700.43700619
87Huntingtons disease_Homo sapiens_hsa050160.42153762
88Vibrio cholerae infection_Homo sapiens_hsa051100.41236212
89Cardiac muscle contraction_Homo sapiens_hsa042600.38622324
90Other glycan degradation_Homo sapiens_hsa005110.38221377
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.36027558
92Spliceosome_Homo sapiens_hsa030400.34561803
93N-Glycan biosynthesis_Homo sapiens_hsa005100.31950844
94Homologous recombination_Homo sapiens_hsa034400.28718080
95Arachidonic acid metabolism_Homo sapiens_hsa005900.27683141
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.25004820
97Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.24371669
98Fructose and mannose metabolism_Homo sapiens_hsa000510.24317537
99RNA transport_Homo sapiens_hsa030130.22794177
100Insulin resistance_Homo sapiens_hsa049310.21809550
101Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.19611875
102Galactose metabolism_Homo sapiens_hsa000520.19300825
103AMPK signaling pathway_Homo sapiens_hsa041520.16876688
104Glucagon signaling pathway_Homo sapiens_hsa049220.16094896
105Ether lipid metabolism_Homo sapiens_hsa005650.11833917
106Collecting duct acid secretion_Homo sapiens_hsa049660.11271356
107Ovarian steroidogenesis_Homo sapiens_hsa049130.09316298
108Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.09165584
109Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.06497813
110Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1818120
111Mineral absorption_Homo sapiens_hsa04978-0.1680123
112Regulation of autophagy_Homo sapiens_hsa04140-0.1251109
113Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412-0.1246767
114Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0862405
115Prion diseases_Homo sapiens_hsa05020-0.0786373
116Protein digestion and absorption_Homo sapiens_hsa04974-0.0638528
117Insulin signaling pathway_Homo sapiens_hsa04910-0.0504293
118Dilated cardiomyopathy_Homo sapiens_hsa05414-0.0500842
119Renin-angiotensin system_Homo sapiens_hsa04614-0.0437557
120Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410-0.0038210

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