ECI1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the hydratase/isomerase superfamily. The protein encoded is a key mitochondrial enzyme involved in beta-oxidation of unsaturated fatty acids. It catalyzes the transformation of 3-cis and 3-trans-enoyl-CoA esters arising during the stepwise degradation of cis-, mono-, and polyunsaturated fatty acids to the 2-trans-enoyl-CoA intermediates. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)9.51644895
2viral transcription (GO:0019083)8.49500262
3translational termination (GO:0006415)8.00757030
4maturation of SSU-rRNA (GO:0030490)7.13370545
5translational elongation (GO:0006414)6.91124134
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.66089621
7cotranslational protein targeting to membrane (GO:0006613)6.54859646
8protein targeting to ER (GO:0045047)6.50384738
9viral life cycle (GO:0019058)6.30421145
10nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)6.23717236
11ribosomal small subunit assembly (GO:0000028)6.23163057
12establishment of protein localization to endoplasmic reticulum (GO:0072599)6.22926982
13cellular protein complex disassembly (GO:0043624)6.19799826
14protein localization to endoplasmic reticulum (GO:0070972)6.12847592
15L-phenylalanine metabolic process (GO:0006558)5.78974305
16erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.78974305
17L-phenylalanine catabolic process (GO:0006559)5.75116246
18erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.75116246
19lysine metabolic process (GO:0006553)5.52426491
20lysine catabolic process (GO:0006554)5.52426491
21protein complex disassembly (GO:0043241)5.49658374
22translational initiation (GO:0006413)5.42204874
23glyoxylate metabolic process (GO:0046487)5.32342816
24macromolecular complex disassembly (GO:0032984)5.13291176
25aromatic amino acid family catabolic process (GO:0009074)5.08448506
26* fatty acid beta-oxidation (GO:0006635)5.06500233
27alpha-linolenic acid metabolic process (GO:0036109)4.98666225
28triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.97856841
29fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.97164115
30amino-acid betaine metabolic process (GO:0006577)4.87398845
31kynurenine metabolic process (GO:0070189)4.78547512
32ribosomal large subunit biogenesis (GO:0042273)4.77335992
33regulation of triglyceride catabolic process (GO:0010896)4.75551331
342-oxoglutarate metabolic process (GO:0006103)4.74771835
35ribonucleoprotein complex biogenesis (GO:0022613)4.70213773
36fatty acid transmembrane transport (GO:1902001)4.63312703
37* fatty acid oxidation (GO:0019395)4.59989292
38protein targeting to membrane (GO:0006612)4.58417417
39cellular ketone body metabolic process (GO:0046950)4.58027293
40carnitine shuttle (GO:0006853)4.57695542
41sulfur amino acid catabolic process (GO:0000098)4.57438600
42chaperone-mediated protein transport (GO:0072321)4.56482488
43branched-chain amino acid catabolic process (GO:0009083)4.55607105
44tryptophan catabolic process (GO:0006569)4.55600005
45indole-containing compound catabolic process (GO:0042436)4.55600005
46indolalkylamine catabolic process (GO:0046218)4.55600005
47cysteine metabolic process (GO:0006534)4.55296480
48pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.54367291
49short-chain fatty acid metabolic process (GO:0046459)4.53542034
50* fatty acid catabolic process (GO:0009062)4.52952892
51* lipid oxidation (GO:0034440)4.51648079
52mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.50100132
53bile acid biosynthetic process (GO:0006699)4.45171136
54carnitine metabolic process (GO:0009437)4.43859930
55valine metabolic process (GO:0006573)4.43049835
56tricarboxylic acid cycle (GO:0006099)4.42490587
57ATP synthesis coupled proton transport (GO:0015986)4.41912616
58energy coupled proton transport, down electrochemical gradient (GO:0015985)4.41912616
59serine family amino acid catabolic process (GO:0009071)4.41236617
60acetyl-CoA metabolic process (GO:0006084)4.40594994
61tryptophan metabolic process (GO:0006568)4.36344215
62aspartate family amino acid catabolic process (GO:0009068)4.35342908
63translation (GO:0006412)4.33448597
64regulation of sequestering of triglyceride (GO:0010889)4.31629369
65deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.25929338
66ethanol oxidation (GO:0006069)4.24968304
67regulation of mitochondrial translation (GO:0070129)4.21134765
68* monocarboxylic acid catabolic process (GO:0072329)4.21005408
69branched-chain amino acid metabolic process (GO:0009081)4.20362054
70L-serine metabolic process (GO:0006563)4.14742702
71alpha-amino acid catabolic process (GO:1901606)4.08990782
72cellular component biogenesis (GO:0044085)4.07667257
73nuclear-transcribed mRNA catabolic process (GO:0000956)4.07095178
74establishment of protein localization to mitochondrial membrane (GO:0090151)4.06662647
75homocysteine metabolic process (GO:0050667)4.03481142
76urea metabolic process (GO:0019627)4.03363096
77urea cycle (GO:0000050)4.03363096
78biotin metabolic process (GO:0006768)4.01862297
79ketone body metabolic process (GO:1902224)3.98199787
80glycine metabolic process (GO:0006544)3.92975632
81cellular amino acid catabolic process (GO:0009063)3.89973809
82positive regulation of fatty acid beta-oxidation (GO:0032000)3.89624000
83high-density lipoprotein particle remodeling (GO:0034375)3.88759133
84GDP-mannose metabolic process (GO:0019673)3.87404634
85mRNA catabolic process (GO:0006402)3.86915690
86* organic acid catabolic process (GO:0016054)3.86227958
87* carboxylic acid catabolic process (GO:0046395)3.86227958
88triglyceride homeostasis (GO:0070328)3.86150713
89acylglycerol homeostasis (GO:0055090)3.86150713
90nitrogen cycle metabolic process (GO:0071941)3.83368864
91respiratory electron transport chain (GO:0022904)3.82884115
92aromatic amino acid family metabolic process (GO:0009072)3.82748215
93regulation of fatty acid oxidation (GO:0046320)3.82364388
94negative regulation of fibrinolysis (GO:0051918)3.80549647
95DNA replication checkpoint (GO:0000076)3.76288935
96bile acid metabolic process (GO:0008206)3.75752848
97coenzyme catabolic process (GO:0009109)3.75194021
98electron transport chain (GO:0022900)3.75105318
99tricarboxylic acid metabolic process (GO:0072350)3.75022389
100pyrimidine nucleotide catabolic process (GO:0006244)3.73130496
101complement activation, alternative pathway (GO:0006957)3.72015918
102positive regulation of fatty acid oxidation (GO:0046321)3.71907998
103peptidyl-glutamic acid carboxylation (GO:0017187)3.71344818
104protein carboxylation (GO:0018214)3.71344818
105NADH metabolic process (GO:0006734)3.69711987
106serine family amino acid metabolic process (GO:0009069)3.68459465
107negative regulation of fatty acid biosynthetic process (GO:0045717)3.67459045
108regulation of protein activation cascade (GO:2000257)3.67127337
109oxidative phosphorylation (GO:0006119)3.66204596
110regulation of fibrinolysis (GO:0051917)3.65724746
111mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.65550766
112carnitine transmembrane transport (GO:1902603)3.59586639
113tyrosine metabolic process (GO:0006570)3.58895226
114plasma lipoprotein particle clearance (GO:0034381)3.56367793
115RNA catabolic process (GO:0006401)3.55843771
116amino-acid betaine transport (GO:0015838)3.52059848
117carnitine transport (GO:0015879)3.52059848
118regulation of cholesterol esterification (GO:0010872)3.52013541
119plasma lipoprotein particle remodeling (GO:0034369)3.51974508
120protein-lipid complex remodeling (GO:0034368)3.51974508
121macromolecular complex remodeling (GO:0034367)3.51974508
122folic acid metabolic process (GO:0046655)3.49648582
123positive regulation of lipid catabolic process (GO:0050996)3.48428515
124regulation of cholesterol metabolic process (GO:0090181)3.46752906
125serine family amino acid biosynthetic process (GO:0009070)3.44909210
126succinate metabolic process (GO:0006105)3.44216384
127regulation of complement activation (GO:0030449)3.44160645
128oxaloacetate metabolic process (GO:0006107)3.41921245
129reverse cholesterol transport (GO:0043691)3.40822917
130cellular modified amino acid catabolic process (GO:0042219)3.40560088
131establishment of protein localization to membrane (GO:0090150)3.39953598
132protein targeting to mitochondrion (GO:0006626)3.36159182
133regulation of translational fidelity (GO:0006450)3.35547045
134pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.35238016
135ncRNA 3-end processing (GO:0043628)3.32998436
136protein complex biogenesis (GO:0070271)3.32906242
137rRNA modification (GO:0000154)3.32316494
138pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.31108324
139regulation of fatty acid beta-oxidation (GO:0031998)3.30225745
140UTP biosynthetic process (GO:0006228)3.29494876
141regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.27188455
142positive regulation of triglyceride metabolic process (GO:0090208)3.26596916
143mitochondrial respiratory chain complex assembly (GO:0033108)3.25345839
144mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.24927279
145mitochondrial respiratory chain complex I assembly (GO:0032981)3.24927279
146NADH dehydrogenase complex assembly (GO:0010257)3.24927279
147benzene-containing compound metabolic process (GO:0042537)3.24737479
148pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.23566921
149* small molecule catabolic process (GO:0044282)3.23496157
150negative regulation of fatty acid metabolic process (GO:0045922)3.22529933
151negative regulation of sterol transport (GO:0032372)3.22529907
152negative regulation of cholesterol transport (GO:0032375)3.22529907
153phospholipid efflux (GO:0033700)3.21961650
154cellular glucuronidation (GO:0052695)3.21902219
155phospholipid homeostasis (GO:0055091)3.21651073
156acyl-CoA metabolic process (GO:0006637)3.21614427
157rRNA processing (GO:0006364)3.19665137
158proline biosynthetic process (GO:0006561)3.17572744
159establishment of protein localization to mitochondrion (GO:0072655)3.16410851
160protein targeting (GO:0006605)3.16044644
161GTP biosynthetic process (GO:0006183)3.15777651
162pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.15359219
163formation of translation preinitiation complex (GO:0001731)3.08656076
164heterochromatin organization (GO:0070828)3.08498297
165ribosome biogenesis (GO:0042254)3.08080637
166UTP metabolic process (GO:0046051)3.07489248
167CTP metabolic process (GO:0046036)3.04844962
168CTP biosynthetic process (GO:0006241)3.04844962
169base-excision repair, AP site formation (GO:0006285)3.04817678
170nucleobase-containing small molecule interconversion (GO:0015949)3.02066663
171guanosine-containing compound biosynthetic process (GO:1901070)3.01828342
172pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.99888528
173rRNA metabolic process (GO:0016072)2.99527354
174pseudouridine synthesis (GO:0001522)2.98755265
175negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.97331447
176ribonucleoside triphosphate biosynthetic process (GO:0009201)2.96689475
177purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.94549529
178purine nucleoside triphosphate biosynthetic process (GO:0009145)2.92070744
179ATP biosynthetic process (GO:0006754)2.87845912
180protein localization to mitochondrion (GO:0070585)2.87827426
181deoxyribonucleotide catabolic process (GO:0009264)2.87048922
182establishment of protein localization to organelle (GO:0072594)2.85980881
183mitochondrial transport (GO:0006839)2.74713465
184kinetochore assembly (GO:0051382)2.70486887
185protein localization to membrane (GO:0072657)2.70248892
186DNA strand elongation involved in DNA replication (GO:0006271)2.66725819
187creatine metabolic process (GO:0006600)2.66592530
188deoxyribose phosphate catabolic process (GO:0046386)2.66174276
189mitotic chromosome condensation (GO:0007076)2.62080786
190nucleoside triphosphate biosynthetic process (GO:0009142)2.60511684
191rRNA methylation (GO:0031167)2.60430419
192DNA strand elongation (GO:0022616)2.60230291
193proline metabolic process (GO:0006560)2.56882408
194regulation of cellular respiration (GO:0043457)2.54436865
195metallo-sulfur cluster assembly (GO:0031163)2.53175221

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.51087893
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.83015935
3RXR_22158963_ChIP-Seq_LIVER_Mouse6.56325209
4PPARA_22158963_ChIP-Seq_LIVER_Mouse5.92471708
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.91415318
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.89513959
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.13153483
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.03488605
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.02076850
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.92409212
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.12139015
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.10133995
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.06741593
14XRN2_22483619_ChIP-Seq_HELA_Human2.64627475
15E2F7_22180533_ChIP-Seq_HELA_Human2.59539100
16VDR_21846776_ChIP-Seq_THP-1_Human2.51505512
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.24518281
18HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.23002839
19ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.21658340
20THAP11_20581084_ChIP-Seq_MESCs_Mouse2.08088909
21GATA1_22025678_ChIP-Seq_K562_Human1.99628287
22MYC_19030024_ChIP-ChIP_MESCs_Mouse1.95074396
23DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.92213380
24CLOCK_20551151_ChIP-Seq_293T_Human1.90745279
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.90125945
26EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.88006077
27SRY_22984422_ChIP-ChIP_TESTIS_Rat1.85378713
28ZNF263_19887448_ChIP-Seq_K562_Human1.72574754
29CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.69831962
30TTF2_22483619_ChIP-Seq_HELA_Human1.65344539
31TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.64822310
32GABP_19822575_ChIP-Seq_HepG2_Human1.63393800
33FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.59646286
34ERG_21242973_ChIP-ChIP_JURKAT_Human1.57540943
35RARG_19884340_ChIP-ChIP_MEFs_Mouse1.53637175
36FOXM1_23109430_ChIP-Seq_U2OS_Human1.51681620
37STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.50521120
38STAT3_1855785_ChIP-Seq_MESCs_Mouse1.46733089
39CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.45909436
40CTCF_18555785_ChIP-Seq_MESCs_Mouse1.44429656
41MYC_22102868_ChIP-Seq_BL_Human1.44402333
42E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.43818045
43* FOXP1_21924763_ChIP-Seq_HESCs_Human1.43736223
44SA1_27219007_Chip-Seq_ERYTHROID_Human1.41948253
45NELFA_20434984_ChIP-Seq_ESCs_Mouse1.39264235
46ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.39216307
47KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.38491766
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.37782839
49CTCF_27219007_Chip-Seq_Bcells_Human1.34958932
50SRF_21415370_ChIP-Seq_HL-1_Mouse1.33568836
51CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.32512289
52TP63_17297297_ChIP-ChIP_HaCaT_Human1.32390369
53PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.31626791
54SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.31392059
55NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.26789354
56SMC4_20622854_ChIP-Seq_HELA_Human1.26294886
57POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.25257681
58KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23227528
59YY1_21170310_ChIP-Seq_MESCs_Mouse1.22864631
60* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.22155892
61KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.22040154
62ELF1_20517297_ChIP-Seq_JURKAT_Human1.21621583
63EST1_17652178_ChIP-ChIP_JURKAT_Human1.20813723
64KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.19642675
65MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.19287224
66THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.18080807
67ELK3_25401928_ChIP-Seq_HUVEC_Human1.17875890
68CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.15582471
69KDM5A_27292631_Chip-Seq_BREAST_Human1.14985654
70KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.14829039
71PHF8_20622854_ChIP-Seq_HELA_Human1.14727327
72TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12992399
73ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.12127860
74JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.12090706
75E2F1_21310950_ChIP-Seq_MCF-7_Human1.11377871
76CTCF_27219007_Chip-Seq_ERYTHROID_Human1.09474101
77E2F1_20622854_ChIP-Seq_HELA_Human1.09450586
78PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.09122543
79ESR1_15608294_ChIP-ChIP_MCF-7_Human1.08997700
80CREB1_26743006_Chip-Seq_LNCaP_Human1.08983026
81TBX20_22328084_ChIP-Seq_HEART_Mouse1.08683954
82TBX20_22080862_ChIP-Seq_HEART_Mouse1.08683954
83UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.07611533
84SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.06531726
85SA1_27219007_Chip-Seq_Bcells_Human1.06256906
86HNF4A_19822575_ChIP-Seq_HepG2_Human1.05294307
87MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.05104361
88BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04378067
89YY1_22570637_ChIP-Seq_MALME-3M_Human1.04133415
90NANOG_18555785_ChIP-Seq_MESCs_Mouse1.03488513
91PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.03004333
92TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.00756397
93CREB1_15753290_ChIP-ChIP_HEK293T_Human1.00320753
94RXRA_24833708_ChIP-Seq_LIVER_Mouse1.00156015
95NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.97068500
96E2F1_18555785_ChIP-Seq_MESCs_Mouse0.96408758
97FOXA2_19822575_ChIP-Seq_HepG2_Human0.95459658
98MYC_18358816_ChIP-ChIP_MESCs_Mouse0.94447566
99MYC_18555785_ChIP-Seq_MESCs_Mouse0.90606956
100GATA4_21415370_ChIP-Seq_HL-1_Mouse0.89684479
101STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.89162346
102NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.88568604
103CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.85733617
104SOX2_27498859_Chip-Seq_STOMACH_Mouse0.82951627
105SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.81348081
106HTT_18923047_ChIP-ChIP_STHdh_Human0.79299707
107GATA4_25053715_ChIP-Seq_YYC3_Human0.77502149
108AUTS2_25519132_ChIP-Seq_293T-REX_Human0.75663111
109IRF8_22096565_ChIP-ChIP_GC-B_Human0.74991524
110GATA1_22383799_ChIP-Seq_G1ME_Mouse0.74546495
111BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.74062593
112CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.73108458
113BCL6_27268052_Chip-Seq_Bcells_Human0.72519618
114PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.72350915
115IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.70330840
116ELF1_17652178_ChIP-ChIP_JURKAT_Human0.70234884
117BCOR_27268052_Chip-Seq_Bcells_Human0.69239839
118CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.69066081
119ZFX_18555785_ChIP-Seq_MESCs_Mouse0.68782078
120LXR_22292898_ChIP-Seq_THP-1_Human0.67399165
121TET1_21451524_ChIP-Seq_MESCs_Mouse0.66931003
122RAD21_21589869_ChIP-Seq_MESCs_Mouse0.66797771
123RARA_24833708_ChIP-Seq_LIVER_Mouse0.66240658
124ETS1_20019798_ChIP-Seq_JURKAT_Human0.66071243
125PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.65469382
126TBX5_21415370_ChIP-Seq_HL-1_Mouse0.65018486
127NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.64622871
128CEBPB_22108803_ChIP-Seq_LS180_Human0.63429084
129RARB_24833708_ChIP-Seq_LIVER_Mouse0.63284411
130RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.63010271
131POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.62959825
132GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.61935881
133DCP1A_22483619_ChIP-Seq_HELA_Human0.61821105
134CTCF_21964334_Chip-Seq_Bcells_Human0.61471852
135AR_20517297_ChIP-Seq_VCAP_Human0.61251616
136LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.61188506
137SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.60785888
138ATF3_27146783_Chip-Seq_COLON_Human0.60517245
139SOX2_18692474_ChIP-Seq_MEFs_Mouse0.59608966
140RACK7_27058665_Chip-Seq_MCF-7_Human0.59458502
141FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.59443564
142ERG_20517297_ChIP-Seq_VCAP_Human0.59231461
143P68_20966046_ChIP-Seq_HELA_Human0.59039630
144SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.58767015
145TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.58523432
146MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.58145265
147ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.58113226
148TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.57842788
149GABP_17652178_ChIP-ChIP_JURKAT_Human0.57586168
150GATA1_19941827_ChIP-Seq_MEL_Mouse0.56018953
151ESR1_20079471_ChIP-ChIP_T-47D_Human0.55907405
152SPI1_20517297_ChIP-Seq_HL60_Human0.54393777
153CTCF_26484167_Chip-Seq_Bcells_Mouse0.54164750
154OCT4_18692474_ChIP-Seq_MEFs_Mouse0.53864107

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.29797665
2MP0009379_abnormal_foot_pigmentation6.23633508
3MP0005360_urolithiasis5.54601704
4MP0005085_abnormal_gallbladder_physiolo4.98717007
5MP0005365_abnormal_bile_salt4.83638881
6MP0003806_abnormal_nucleotide_metabolis4.16730154
7MP0008875_abnormal_xenobiotic_pharmacok3.71429627
8MP0010030_abnormal_orbit_morphology3.36081652
9MP0002837_dystrophic_cardiac_calcinosis3.17749443
10MP0003136_yellow_coat_color2.95248984
11MP0003252_abnormal_bile_duct2.94232637
12MP0010329_abnormal_lipoprotein_level2.92858558
13MP0009840_abnormal_foam_cell2.80487907
14MP0003123_paternal_imprinting2.78252502
15MP0003646_muscle_fatigue2.74930198
16MP0005332_abnormal_amino_acid2.70899961
17MP0003693_abnormal_embryo_hatching2.54927888
18MP0005670_abnormal_white_adipose2.52638235
19MP0006292_abnormal_olfactory_placode2.52327165
20MP0000678_abnormal_parathyroid_gland2.34586252
21MP0006036_abnormal_mitochondrial_physio2.34577759
22MP0002249_abnormal_larynx_morphology2.34454951
23MP0003195_calcinosis2.32724138
24MP0005083_abnormal_biliary_tract2.27226186
25MP0004130_abnormal_muscle_cell2.21070446
26MP0003111_abnormal_nucleus_morphology2.05478142
27MP0001666_abnormal_nutrient_absorption2.04380935
28MP0004084_abnormal_cardiac_muscle2.04123221
29MP0005330_cardiomyopathy2.01400263
30MP0002118_abnormal_lipid_homeostasis1.99963511
31MP0003191_abnormal_cellular_cholesterol1.97416700
32MP0005319_abnormal_enzyme/_coenzyme1.92536649
33MP0000609_abnormal_liver_physiology1.90476856
34MP0005666_abnormal_adipose_tissue1.83504312
35MP0004957_abnormal_blastocyst_morpholog1.82782804
36MP0004215_abnormal_myocardial_fiber1.80748017
37MP0003186_abnormal_redox_activity1.77466689
38MP0004858_abnormal_nervous_system1.76658539
39MP0000049_abnormal_middle_ear1.76335073
40MP0002163_abnormal_gland_morphology1.74018946
41MP0002653_abnormal_ependyma_morphology1.73520977
42MP0008932_abnormal_embryonic_tissue1.70212893
43MP0004036_abnormal_muscle_relaxation1.68558672
44MP0000566_synostosis1.64689144
45MP0004233_abnormal_muscle_weight1.64301402
46MP0005584_abnormal_enzyme/coenzyme_acti1.62979890
47MP0004019_abnormal_vitamin_homeostasis1.60146929
48MP0000751_myopathy1.55072160
49MP0005451_abnormal_body_composition1.54899908
50MP0001764_abnormal_homeostasis1.54095159
51MP0000749_muscle_degeneration1.51571230
52MP0004145_abnormal_muscle_electrophysio1.51326090
53MP0002138_abnormal_hepatobiliary_system1.50119179
54MP0009643_abnormal_urine_homeostasis1.43953129
55MP0003077_abnormal_cell_cycle1.39890271
56MP0006035_abnormal_mitochondrial_morpho1.36992262
57MP0003656_abnormal_erythrocyte_physiolo1.34049510
58MP0002971_abnormal_brown_adipose1.33472105
59MP0002234_abnormal_pharynx_morphology1.30316910
60MP0003315_abnormal_perineum_morphology1.29773162
61MP0002938_white_spotting1.29396848
62MP0005501_abnormal_skin_physiology1.28353137
63MP0002160_abnormal_reproductive_system1.27775500
64MP0009697_abnormal_copulation1.25723041
65MP0000003_abnormal_adipose_tissue1.24912087
66MP0009053_abnormal_anal_canal1.24686054
67MP0004087_abnormal_muscle_fiber1.24346745
68MP0008775_abnormal_heart_ventricle1.24280978
69MP0001188_hyperpigmentation1.23620652
70MP0010094_abnormal_chromosome_stability1.22667448
71MP0005385_cardiovascular_system_phenoty1.22416996
72MP0001544_abnormal_cardiovascular_syste1.22416996
73MP0002972_abnormal_cardiac_muscle1.18853941
74MP0010368_abnormal_lymphatic_system1.17490323
75MP0003868_abnormal_feces_composition1.17229055
76MP0003942_abnormal_urinary_system1.15977350
77MP0002269_muscular_atrophy1.15556327
78MP0005058_abnormal_lysosome_morphology1.13827304
79MP0005266_abnormal_metabolism1.12919501
80MP0003011_delayed_dark_adaptation1.12868269
81MP0005174_abnormal_tail_pigmentation1.11603272
82MP0010630_abnormal_cardiac_muscle1.11387146
83MP0002697_abnormal_eye_size1.10053275
84MP0003221_abnormal_cardiomyocyte_apopto1.09612752
85MP0003137_abnormal_impulse_conducting1.07440054
86MP0000750_abnormal_muscle_regeneration1.06828926
87MP0004185_abnormal_adipocyte_glucose1.05718824
88MP0006138_congestive_heart_failure1.04683063
89MP0000598_abnormal_liver_morphology1.03531300
90MP0003879_abnormal_hair_cell1.02007552
91MP0001502_abnormal_circadian_rhythm1.01959301
92MP0005620_abnormal_muscle_contractility1.01259445
93MP0003705_abnormal_hypodermis_morpholog0.99874595
94MP0002078_abnormal_glucose_homeostasis0.98841355
95MP0005375_adipose_tissue_phenotype0.97961383
96MP0005334_abnormal_fat_pad0.93678969
97MP0001293_anophthalmia0.91863646
98MP0005636_abnormal_mineral_homeostasis0.91444636
99MP0008789_abnormal_olfactory_epithelium0.90466266
100MP0005535_abnormal_body_temperature0.90442725
101MP0001346_abnormal_lacrimal_gland0.90264851
102MP0000681_abnormal_thyroid_gland0.88938862
103MP0009763_increased_sensitivity_to0.88182070
104MP0004043_abnormal_pH_regulation0.86822569
105MP0004147_increased_porphyrin_level0.86247107
106MP0002332_abnormal_exercise_endurance0.85990805
107MP0005376_homeostasis/metabolism_phenot0.84032397
108MP0009250_abnormal_appendicular_skeleto0.83874164
109MP0005423_abnormal_somatic_nervous0.83431637
110MP0004133_heterotaxia0.81892717
111MP0009642_abnormal_blood_homeostasis0.80233976
112MP0001853_heart_inflammation0.80092671
113MP0002106_abnormal_muscle_physiology0.79272240
114MP0000762_abnormal_tongue_morphology0.79041693
115MP0005647_abnormal_sex_gland0.77984143
116MP0008058_abnormal_DNA_repair0.77941346
117MP0000350_abnormal_cell_proliferation0.77298224
118MP0009764_decreased_sensitivity_to0.77141776
119MP0008469_abnormal_protein_level0.76521894
120MP0003938_abnormal_ear_development0.75410912
121MP0001756_abnormal_urination0.75213773
122MP0002638_abnormal_pupillary_reflex0.75103358
123MP0001905_abnormal_dopamine_level0.74366764
124MP0003828_pulmonary_edema0.73345140
125MP0000313_abnormal_cell_death0.73114431
126MP0000747_muscle_weakness0.73049694
127MP0000230_abnormal_systemic_arterial0.72421384
128MP0000343_altered_response_to0.72084947
129MP0002111_abnormal_tail_morphology0.72011008
130MP0001881_abnormal_mammary_gland0.71814032
131MP0009115_abnormal_fat_cell0.69791273
132MP0005394_taste/olfaction_phenotype0.69642656
133MP0005499_abnormal_olfactory_system0.69642656
134MP0002970_abnormal_white_adipose0.68961980
135MP0001697_abnormal_embryo_size0.68007149
136MP0002092_abnormal_eye_morphology0.67840569
137MP0003786_premature_aging0.66432461
138MP0005379_endocrine/exocrine_gland_phen0.66212735
139MP0002796_impaired_skin_barrier0.65537484
140MP0002116_abnormal_craniofacial_bone0.64928390
141MP0002080_prenatal_lethality0.64705167
142MP0005377_hearing/vestibular/ear_phenot0.64430645
143MP0003878_abnormal_ear_physiology0.64430645
144MP0001730_embryonic_growth_arrest0.63750860
145MP0002085_abnormal_embryonic_tissue0.63386829
146MP0000733_abnormal_muscle_development0.63010549
147MP0000759_abnormal_skeletal_muscle0.62349461
148MP0001661_extended_life_span0.61467091
149MP0004484_altered_response_of0.60376077
150MP0005084_abnormal_gallbladder_morpholo0.60041434
151MP0005369_muscle_phenotype0.58297319
152MP0002127_abnormal_cardiovascular_syste0.57884608
153MP0005165_increased_susceptibility_to0.57861315
154MP0004085_abnormal_heartbeat0.55921151
155MP0005220_abnormal_exocrine_pancreas0.55605940
156MP0005448_abnormal_energy_balance0.55338149
157MP0003724_increased_susceptibility_to0.55184974
158MP0002136_abnormal_kidney_physiology0.50574977
159MP0003567_abnormal_fetal_cardiomyocyte0.49497358
160MP0002254_reproductive_system_inflammat0.46972531
161MP0003279_aneurysm0.46359644
162MP0003953_abnormal_hormone_level0.44933738
163MP0002132_abnormal_respiratory_system0.43211717
164MP0009765_abnormal_xenobiotic_induced0.43049114

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.88402477
2Abnormality of cells of the erythroid lineage (HP:0012130)5.42300349
3Abnormality of aromatic amino acid family metabolism (HP:0004338)5.00999547
4Hypoglycemic coma (HP:0001325)4.99441995
5Hyperglycinuria (HP:0003108)4.82670587
6Hyperammonemia (HP:0001987)4.76993627
7Abnormality of fatty-acid metabolism (HP:0004359)4.74789392
8Abnormal number of erythroid precursors (HP:0012131)4.74721973
9Intrahepatic cholestasis (HP:0001406)4.72246350
10Ketosis (HP:0001946)4.55830636
11Macrocytic anemia (HP:0001972)4.52952242
12Xanthomatosis (HP:0000991)4.40427943
13Aplasia/Hypoplasia of the sacrum (HP:0008517)4.39930090
14Abnormality of glycine metabolism (HP:0010895)4.37120681
15Abnormality of serine family amino acid metabolism (HP:0010894)4.37120681
16Dicarboxylic aciduria (HP:0003215)4.34950683
17Abnormality of dicarboxylic acid metabolism (HP:0010995)4.34950683
18Deep venous thrombosis (HP:0002625)4.32077875
19Abnormality of monocarboxylic acid metabolism (HP:0010996)4.17500648
20Ketoacidosis (HP:0001993)4.12765442
21Hyperglycinemia (HP:0002154)4.12232884
22Myoglobinuria (HP:0002913)4.02027620
23Hyperlipoproteinemia (HP:0010980)3.97035782
24Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.96744357
25Hypobetalipoproteinemia (HP:0003563)3.95531425
26Hepatic necrosis (HP:0002605)3.88938148
27Generalized aminoaciduria (HP:0002909)3.79695096
28Prolonged partial thromboplastin time (HP:0003645)3.79203034
29Cerebral edema (HP:0002181)3.70275452
30Hypoalphalipoproteinemia (HP:0003233)3.54471580
31Pallor (HP:0000980)3.53459985
32Hyperthyroidism (HP:0000836)3.52261522
33Hypolipoproteinemia (HP:0010981)3.52227345
34Rhabdomyolysis (HP:0003201)3.50670417
35Lethargy (HP:0001254)3.34421660
36Abnormality of aspartate family amino acid metabolism (HP:0010899)3.30054697
37Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.26816032
38Metabolic acidosis (HP:0001942)3.21542243
39Increased muscle lipid content (HP:0009058)3.21156623
40Abnormality of serum amino acid levels (HP:0003112)3.18270122
41Progressive muscle weakness (HP:0003323)3.14136210
42Abnormality of methionine metabolism (HP:0010901)3.10879771
43Abnormality of glutamine family amino acid metabolism (HP:0010902)3.08852906
44Acute encephalopathy (HP:0006846)3.08775299
45Myopathic facies (HP:0002058)3.04156085
46Hepatocellular necrosis (HP:0001404)3.00376938
47Complement deficiency (HP:0004431)2.99416917
48Rib fusion (HP:0000902)2.98760640
49Ventricular tachycardia (HP:0004756)2.97886580
50Abnormality of reticulocytes (HP:0004312)2.97575905
51Abnormality of sulfur amino acid metabolism (HP:0004339)2.97495053
52Exercise intolerance (HP:0003546)2.97484795
53Epidermoid cyst (HP:0200040)2.89478821
54Sudden death (HP:0001699)2.89107064
55Palpitations (HP:0001962)2.87805496
56Increased hepatocellular lipid droplets (HP:0006565)2.87328589
57Exercise-induced myalgia (HP:0003738)2.85986891
58Renal Fanconi syndrome (HP:0001994)2.83738663
59Testicular atrophy (HP:0000029)2.83136848
60Nausea (HP:0002018)2.82561768
61Delayed CNS myelination (HP:0002188)2.82558130
62Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.80105329
63Proximal tubulopathy (HP:0000114)2.79226791
64Lactic acidosis (HP:0003128)2.69762055
65Hyperbilirubinemia (HP:0002904)2.68624649
66Abnormal mitochondria in muscle tissue (HP:0008316)2.68592046
67Partial duplication of thumb phalanx (HP:0009944)2.67896334
68Vomiting (HP:0002013)2.66399766
69Joint hemorrhage (HP:0005261)2.65987591
70Abnormality of the common coagulation pathway (HP:0010990)2.65068014
71Absent thumb (HP:0009777)2.63537122
72Microretrognathia (HP:0000308)2.62130871
73Renal cortical cysts (HP:0000803)2.59983100
74Increased intramyocellular lipid droplets (HP:0012240)2.55885675
75Acute necrotizing encephalopathy (HP:0006965)2.53871001
76Truncus arteriosus (HP:0001660)2.53711024
77Fat malabsorption (HP:0002630)2.48451452
78Ragged-red muscle fibers (HP:0003200)2.47739806
79Abnormality of the intrinsic pathway (HP:0010989)2.47551999
80Lipoatrophy (HP:0100578)2.45140543
81Partial duplication of the phalanx of hand (HP:0009999)2.44835109
82Birth length less than 3rd percentile (HP:0003561)2.43546044
83Exercise-induced muscle cramps (HP:0003710)2.43316915
84Right ventricular cardiomyopathy (HP:0011663)2.43005619
85Abnormality of purine metabolism (HP:0004352)2.42967886
86Abnormality of urine glucose concentration (HP:0011016)2.42368556
87Glycosuria (HP:0003076)2.42368556
88Abnormality of nucleobase metabolism (HP:0010932)2.41781495
89Decreased activity of mitochondrial respiratory chain (HP:0008972)2.41623645
90Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.41623645
91Gout (HP:0001997)2.39473965
92Abnormality of pyrimidine metabolism (HP:0004353)2.39408711
93Increased CSF lactate (HP:0002490)2.38804763
94Hypercholesterolemia (HP:0003124)2.34794667
95Respiratory difficulties (HP:0002880)2.33430768
96Dilated cardiomyopathy (HP:0001644)2.33360711
97Atrioventricular block (HP:0001678)2.32423389
98Mitochondrial inheritance (HP:0001427)2.31228040
99Late onset (HP:0003584)2.29797521
100Broad distal phalanx of finger (HP:0009836)2.26469514
101Breast hypoplasia (HP:0003187)2.24837519
102Hyperinsulinemic hypoglycemia (HP:0000825)2.24283030
103Asymmetric septal hypertrophy (HP:0001670)2.24099010
104Cholelithiasis (HP:0001081)2.23525106
105Methylmalonic aciduria (HP:0012120)2.23524730
106Calf muscle hypertrophy (HP:0008981)2.19709882
107Hypoglycemic seizures (HP:0002173)2.18549297
108Lipid accumulation in hepatocytes (HP:0006561)2.18521298
109Vaginal fistula (HP:0004320)2.18180020
110Abnormality of glycolysis (HP:0004366)2.17634017
111Increased serum pyruvate (HP:0003542)2.17634017
112Abnormality of the tricuspid valve (HP:0001702)2.16753523
113Skin nodule (HP:0200036)2.15101723
114Abnormal gallbladder morphology (HP:0012437)2.14795082
115Duplication of thumb phalanx (HP:0009942)2.13391849
116Abnormality of complement system (HP:0005339)2.10041485
117Muscle stiffness (HP:0003552)2.08524726
118Muscle fiber inclusion bodies (HP:0100299)2.06865219
119Abnormal cartilage morphology (HP:0002763)2.06589209
120Pancreatitis (HP:0001733)2.05419726
121Increased serum lactate (HP:0002151)2.03864566
122Progressive macrocephaly (HP:0004481)2.03624288
123Ulnar bowing (HP:0003031)2.02960820
124Microvesicular hepatic steatosis (HP:0001414)2.02484732
125Increased purine levels (HP:0004368)2.02040088
126Hyperuricemia (HP:0002149)2.02040088
127Myokymia (HP:0002411)2.01863231
128Conjugated hyperbilirubinemia (HP:0002908)2.00146228
129Heart block (HP:0012722)1.99648012
130Hypertriglyceridemia (HP:0002155)1.98919547
131Achilles tendon contracture (HP:0001771)1.98829133
132Atrial fibrillation (HP:0005110)1.98603518
133Hypoplasia of the radius (HP:0002984)1.97231909
134Respiratory failure (HP:0002878)1.96543266
135Hyperalaninemia (HP:0003348)1.96438563
136Calcaneovalgus deformity (HP:0001848)1.95922569
137Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.95740939
138Nemaline bodies (HP:0003798)1.94375514
139Delayed epiphyseal ossification (HP:0002663)1.92278814
140Rectal fistula (HP:0100590)1.91419437
141Rectovaginal fistula (HP:0000143)1.91419437
142Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.89514634
143Turricephaly (HP:0000262)1.87372098
144Rectal prolapse (HP:0002035)1.84648998
145Abnormality of the Achilles tendon (HP:0005109)1.83268275
146Abnormal urine phosphate concentration (HP:0012599)1.79131117
147Squamous cell carcinoma (HP:0002860)1.77599725
148Hypertensive crisis (HP:0100735)1.77558144
149Myotonia (HP:0002486)1.77392666
150Muscle fiber atrophy (HP:0100295)1.75146026
151Coronal craniosynostosis (HP:0004440)1.74021357
152Aplasia/Hypoplasia of the patella (HP:0006498)1.74009484
153Hypoplastic heart (HP:0001961)1.72816970
154Maternal diabetes (HP:0009800)1.70198298
155Hypoparathyroidism (HP:0000829)1.68510823
156Bulbar palsy (HP:0001283)1.68383004
157Congenital malformation of the right heart (HP:0011723)1.67269132
158Double outlet right ventricle (HP:0001719)1.67269132
159Deformed tarsal bones (HP:0008119)1.67084943
160Abnormality of cochlea (HP:0000375)1.64746277
161Type 1 muscle fiber predominance (HP:0003803)1.63093920
162Esophageal neoplasm (HP:0100751)1.62977492
163Neoplasm of head and neck (HP:0012288)1.62977492
164Hyperphosphaturia (HP:0003109)1.62928548
165Patellar aplasia (HP:0006443)1.60701782
166Intestinal fistula (HP:0100819)1.60223504

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.29473021
2TRIB33.08103626
3VRK23.03193456
4SMG12.95017304
5PDK42.92407979
6PDK32.92407979
7PKN22.90489805
8TTN2.85210758
9TLK12.82317795
10ERN12.64896634
11LMTK22.57533054
12TIE12.56793363
13NME22.53638927
14CDC72.37262430
15ARAF2.30876055
16MYLK2.29667127
17FGFR42.27753358
18OBSCN2.27658524
19SIK12.20547217
20FLT32.19457215
21PINK12.15673297
22BUB11.91512543
23PIM21.84283792
24PHKG21.80293149
25PHKG11.80293149
26PDK21.70083309
27NEK11.61729005
28EEF2K1.59292073
29BRAF1.57430045
30INSRR1.55965556
31KDR1.54575970
32AURKA1.54156121
33MAP2K31.51891625
34NME11.44201063
35ICK1.43162986
36MAP3K31.40635833
37PRKD31.39865154
38IRAK31.37206948
39STK38L1.31946607
40MUSK1.31169491
41MAPK111.30957506
42PIK3CA1.30820305
43NEK91.26711940
44EPHA21.26089371
45PRKAA21.19976963
46TGFBR21.16260310
47PIK3CG1.14777733
48TESK21.14587165
49CHEK21.11869363
50DYRK21.06845157
51EPHB21.05932622
52MAPKAPK31.05717237
53STK161.05390978
54MST1R1.04677238
55MAP3K111.03867651
56EIF2AK10.95557880
57AURKB0.93753596
58STK240.90820633
59TYK20.89493783
60ABL20.88362247
61NEK20.85975009
62MAP3K70.83908407
63CDK70.82380249
64VRK10.81378870
65MAPK120.81314258
66PRKAA10.80885662
67LATS10.79448518
68TAF10.77343438
69ILK0.76523378
70CDK80.76503506
71IRAK20.76305338
72PRKCI0.74912849
73LIMK10.73156550
74TAOK30.70991470
75TBK10.70508221
76DYRK30.69585612
77PTK60.69107784
78TESK10.68281896
79PLK10.68114182
80CAMK1D0.66582883
81RPS6KA50.65677516
82CCNB10.65302620
83WNK40.63255243
84RPS6KA20.62718968
85ATR0.62035677
86MAP2K60.61555986
87TTK0.61523548
88PRKD10.60826558
89CDK40.60623412
90CDK190.59302291
91TGFBR10.59119865
92CSNK2A20.58541581
93MAP3K80.58221459
94RIPK10.58058821
95LRRK20.55640176
96PAK10.54807405
97JAK20.54244899
98ZAK0.54064769
99MAPK40.53364597
100STK40.53247562
101CHEK10.53172425
102MAP3K50.52953708
103PRKG20.52654558
104PRKACG0.51363860
105PBK0.51071888
106CDK11A0.51055072
107BRSK10.50594056
108TAOK20.49430037
109ERBB40.49302222
110CSNK2A10.47821511
111CAMK2G0.46377742
112MARK20.44815798
113MAPK150.44795394
114MAP2K40.42539206
115KIT0.41901118
116FRK0.41571854
117CDK20.39998180
118CDK150.39531832
119AKT20.39256904
120MAP3K100.38733342
121PRKD20.38650992
122SCYL20.38422577
123TYRO30.38190433
124MAP4K10.37288291
125JAK10.36818094
126GRK70.36595529
127CAMK2D0.35329465
128DAPK30.34829798
129PDPK10.33875076
130BMX0.33870371
131MAP3K90.33545613
132CAMK40.33495974
133DMPK0.28986121
134DYRK1B0.28655573
135TEC0.27861613
136CDK60.27695923
137RPS6KB20.27479093
138RPS6KL10.27220991
139RPS6KC10.27220991
140BTK0.26856041
141RPS6KA60.24951539
142MAP2K20.24678395
143MTOR0.24198818
144PRKACB0.23628541
145TRPM70.22641853
146NLK0.22413007
147PRKACA0.22298771
148PDK10.21612557
149GSK3A0.19302886
150RPS6KA10.18730131
151BRSK20.18720466
152ZAP700.17588633

Predicted pathways (KEGG)

RankGene SetZ-score
1* Fatty acid degradation_Homo sapiens_hsa000713.35273837
2Propanoate metabolism_Homo sapiens_hsa006403.29144934
3Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.23249240
4Primary bile acid biosynthesis_Homo sapiens_hsa001203.17006776
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.95605946
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.94079965
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.90770524
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.82839941
9DNA replication_Homo sapiens_hsa030302.72020747
10Fatty acid metabolism_Homo sapiens_hsa012122.61732471
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.50834286
12Tryptophan metabolism_Homo sapiens_hsa003802.41951426
13Nitrogen metabolism_Homo sapiens_hsa009102.39419696
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.34177585
15Butanoate metabolism_Homo sapiens_hsa006502.31600133
16Arginine biosynthesis_Homo sapiens_hsa002202.30395635
17Base excision repair_Homo sapiens_hsa034102.19178327
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.14702196
19Peroxisome_Homo sapiens_hsa041462.14558803
20PPAR signaling pathway_Homo sapiens_hsa033202.12210450
21Carbon metabolism_Homo sapiens_hsa012002.05670799
22Pyruvate metabolism_Homo sapiens_hsa006202.03674897
23beta-Alanine metabolism_Homo sapiens_hsa004101.88867339
24Pentose and glucuronate interconversions_Homo sapiens_hsa000401.88539759
25Fatty acid elongation_Homo sapiens_hsa000621.86362029
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.72090950
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.71000996
28Mismatch repair_Homo sapiens_hsa034301.69034787
29Complement and coagulation cascades_Homo sapiens_hsa046101.64891155
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.57616002
31Biosynthesis of amino acids_Homo sapiens_hsa012301.53475371
32RNA polymerase_Homo sapiens_hsa030201.45613547
33Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.42592594
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.42567936
35Chemical carcinogenesis_Homo sapiens_hsa052041.40578710
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.39951073
37Homologous recombination_Homo sapiens_hsa034401.33932508
38Folate biosynthesis_Homo sapiens_hsa007901.32675456
39Starch and sucrose metabolism_Homo sapiens_hsa005001.32430446
40Nucleotide excision repair_Homo sapiens_hsa034201.32419207
41Selenocompound metabolism_Homo sapiens_hsa004501.32150563
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.31343278
43Histidine metabolism_Homo sapiens_hsa003401.31262030
44Phenylalanine metabolism_Homo sapiens_hsa003601.29544353
45Sulfur metabolism_Homo sapiens_hsa009201.25915492
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.25835647
47Caffeine metabolism_Homo sapiens_hsa002321.22706579
48Sulfur relay system_Homo sapiens_hsa041221.20837359
49Retinol metabolism_Homo sapiens_hsa008301.20404957
50Steroid hormone biosynthesis_Homo sapiens_hsa001401.17654187
51Tyrosine metabolism_Homo sapiens_hsa003501.17610958
52Fanconi anemia pathway_Homo sapiens_hsa034601.13055056
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.09763012
54Fat digestion and absorption_Homo sapiens_hsa049751.08230484
55Arginine and proline metabolism_Homo sapiens_hsa003301.06315026
56Spliceosome_Homo sapiens_hsa030401.05326113
57Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.02891465
58Parkinsons disease_Homo sapiens_hsa050121.02621887
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.00811281
60Oxidative phosphorylation_Homo sapiens_hsa001901.00753969
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.99209333
62Bile secretion_Homo sapiens_hsa049760.97377045
63Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.96129017
64Staphylococcus aureus infection_Homo sapiens_hsa051500.89893539
65Fatty acid biosynthesis_Homo sapiens_hsa000610.89027258
66Lysine degradation_Homo sapiens_hsa003100.88738013
67ABC transporters_Homo sapiens_hsa020100.88364231
68Cyanoamino acid metabolism_Homo sapiens_hsa004600.87739205
69Pentose phosphate pathway_Homo sapiens_hsa000300.86891954
70Glutathione metabolism_Homo sapiens_hsa004800.80735260
71Vitamin B6 metabolism_Homo sapiens_hsa007500.79043293
72Glycerolipid metabolism_Homo sapiens_hsa005610.78146940
73Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.70256644
74Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.67589526
75One carbon pool by folate_Homo sapiens_hsa006700.67339249
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67166520
77Metabolic pathways_Homo sapiens_hsa011000.66998506
78RNA transport_Homo sapiens_hsa030130.66391652
79Notch signaling pathway_Homo sapiens_hsa043300.66234900
80Vitamin digestion and absorption_Homo sapiens_hsa049770.64989894
81Maturity onset diabetes of the young_Homo sapiens_hsa049500.64146627
82Cardiac muscle contraction_Homo sapiens_hsa042600.61796431
83Basal cell carcinoma_Homo sapiens_hsa052170.60011688
84Alzheimers disease_Homo sapiens_hsa050100.59422617
85Fructose and mannose metabolism_Homo sapiens_hsa000510.58146990
86Cell cycle_Homo sapiens_hsa041100.55297607
87Galactose metabolism_Homo sapiens_hsa000520.54982762
88Bladder cancer_Homo sapiens_hsa052190.52972374
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52045198
90Huntingtons disease_Homo sapiens_hsa050160.51898873
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.49711388
92Insulin resistance_Homo sapiens_hsa049310.44447320
93Steroid biosynthesis_Homo sapiens_hsa001000.42886818
94Systemic lupus erythematosus_Homo sapiens_hsa053220.39137843
95RNA degradation_Homo sapiens_hsa030180.38622440
96Hedgehog signaling pathway_Homo sapiens_hsa043400.37318526
97Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.36512976
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35058100
99Other glycan degradation_Homo sapiens_hsa005110.30179000
100alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28326203
101Alcoholism_Homo sapiens_hsa050340.27810832
102Glucagon signaling pathway_Homo sapiens_hsa049220.27313269
103AMPK signaling pathway_Homo sapiens_hsa041520.26316186
104Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.20137089
105Basal transcription factors_Homo sapiens_hsa030220.19641611
106Linoleic acid metabolism_Homo sapiens_hsa005910.19360304
107Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.17084865
108Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.15034318
109Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.14978690
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.14003550
111Ribosome_Homo sapiens_hsa030100.13297213
112Insulin signaling pathway_Homo sapiens_hsa049100.13075274
113Pyrimidine metabolism_Homo sapiens_hsa002400.12333688
114Dilated cardiomyopathy_Homo sapiens_hsa054140.10900943
115Arachidonic acid metabolism_Homo sapiens_hsa005900.03291576
116Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.1471707
117Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.1272612
118Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412-0.1022326
119Regulation of autophagy_Homo sapiens_hsa04140-0.0903293
120Purine metabolism_Homo sapiens_hsa00230-0.0890378
121Prion diseases_Homo sapiens_hsa05020-0.0858616
122Proteasome_Homo sapiens_hsa03050-0.0540228
123Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0361299
124Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0262546
125Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970-0.0256306

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