ECM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a soluble protein that is involved in endochondral bone formation, angiogenesis, and tumor biology. It also interacts with a variety of extracellular and structural proteins, contributing to the maintenance of skin integrity and homeostasis. Mutations in this gene are associated with lipoid proteinosis disorder (also known as hyalinosis cutis et mucosae or Urbach-Wiethe disease) that is characterized by generalized thickening of skin, mucosae and certain viscera. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of apoptotic cell clearance (GO:2000425)5.94316106
2complement activation, alternative pathway (GO:0006957)5.74588616
3apoptotic cell clearance (GO:0043277)5.74054113
4protein carboxylation (GO:0018214)5.05320730
5peptidyl-glutamic acid carboxylation (GO:0017187)5.05320730
6opsonization (GO:0008228)4.57168311
7barbed-end actin filament capping (GO:0051016)4.54966388
8regulation of integrin activation (GO:0033623)4.48480724
9regulation of complement activation (GO:0030449)4.39608168
10regulation of protein activation cascade (GO:2000257)4.29341087
11cell adhesion mediated by integrin (GO:0033627)4.01181966
12mannose metabolic process (GO:0006013)3.88109924
13regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.87100528
14regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.85484980
15type B pancreatic cell proliferation (GO:0044342)3.77737797
16peptide cross-linking (GO:0018149)3.76505517
17regulation of integrin-mediated signaling pathway (GO:2001044)3.74856268
18protein localization to endosome (GO:0036010)3.74472483
19negative regulation of fibrinolysis (GO:0051918)3.71980408
20regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)3.67303002
21cell migration involved in heart development (GO:0060973)3.67007402
22complement activation (GO:0006956)3.63472461
23negative regulation of nitric oxide biosynthetic process (GO:0045019)3.60750678
24keratinization (GO:0031424)3.60180290
25fibril organization (GO:0097435)3.56199010
26positive regulation of blood coagulation (GO:0030194)3.55032824
27positive regulation of hemostasis (GO:1900048)3.55032824
28hyaluronan catabolic process (GO:0030214)3.53972873
29endothelial cell chemotaxis (GO:0035767)3.48253300
30lipoxygenase pathway (GO:0019372)3.45969242
31extracellular fibril organization (GO:0043206)3.45716886
32fibrinolysis (GO:0042730)3.44881754
33low-density lipoprotein particle clearance (GO:0034383)3.43425126
34collagen metabolic process (GO:0032963)3.42216280
354-hydroxyproline metabolic process (GO:0019471)3.40147781
36negative regulation of smooth muscle cell migration (GO:0014912)3.37960702
37positive regulation of coagulation (GO:0050820)3.37074153
38substrate-dependent cell migration (GO:0006929)3.36700397
39adhesion of symbiont to host (GO:0044406)3.36368532
40glycosphingolipid catabolic process (GO:0046479)3.36278430
41collagen catabolic process (GO:0030574)3.35278968
42positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.35039929
43regulation of early endosome to late endosome transport (GO:2000641)3.33845995
44Golgi transport vesicle coating (GO:0048200)3.33265481
45COPI coating of Golgi vesicle (GO:0048205)3.33265481
46stress fiber assembly (GO:0043149)3.32752108
47pinocytosis (GO:0006907)3.32263328
48skin morphogenesis (GO:0043589)3.31406763
49decidualization (GO:0046697)3.30716756
50sequestering of extracellular ligand from receptor (GO:0035581)3.26908336
51detection of molecule of bacterial origin (GO:0032490)3.24840354
52hemidesmosome assembly (GO:0031581)3.22783595
53adhesion of symbiont to host cell (GO:0044650)3.20186728
54virion attachment to host cell (GO:0019062)3.20186728
55glial cell migration (GO:0008347)3.18414983
56positive regulation of chemokine biosynthetic process (GO:0045080)3.18119223
57negative regulation of homotypic cell-cell adhesion (GO:0034111)3.18009348
58plasma lipoprotein particle clearance (GO:0034381)3.17692184
59cellular response to interferon-alpha (GO:0035457)3.16953018
60endodermal cell differentiation (GO:0035987)3.14464619
61multicellular organismal macromolecule metabolic process (GO:0044259)3.10644816
62regulation of fibrinolysis (GO:0051917)3.09540417
63peptidyl-proline hydroxylation (GO:0019511)3.07703616
64regulation of macrophage chemotaxis (GO:0010758)3.07317801
65regulation of humoral immune response (GO:0002920)3.06621119
66multicellular organismal catabolic process (GO:0044243)3.04356146
67basement membrane organization (GO:0071711)3.04002121
68regulation of endothelial cell chemotaxis (GO:2001026)3.02683294
69positive regulation of fatty acid biosynthetic process (GO:0045723)3.02235589
70positive regulation of osteoblast proliferation (GO:0033690)3.02222811
71extracellular matrix disassembly (GO:0022617)3.01842472
72complement activation, classical pathway (GO:0006958)3.00432868
73protein activation cascade (GO:0072376)2.97286630
74chondrocyte proliferation (GO:0035988)2.97188810
75glycolipid catabolic process (GO:0019377)2.96790423
76vascular endothelial growth factor signaling pathway (GO:0038084)2.95071868
77regulation of vitamin D biosynthetic process (GO:0060556)2.93501978
78urea cycle (GO:0000050)2.91190528
79urea metabolic process (GO:0019627)2.91190528
80positive regulation of natural killer cell differentiation (GO:0032825)2.91027839
81multicellular organismal metabolic process (GO:0044236)2.90280258
82triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.90196262
83negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.89884436
84collagen fibril organization (GO:0030199)2.87587908
85platelet degranulation (GO:0002576)2.85590531
86endocytic recycling (GO:0032456)2.85320314
87alpha-linolenic acid metabolic process (GO:0036109)2.81241268
88regulation of plasminogen activation (GO:0010755)2.81065394
89citrulline biosynthetic process (GO:0019240)2.79429195
90negative regulation of nitric-oxide synthase activity (GO:0051001)2.78964200
91hypotonic response (GO:0006971)2.77174438
92protein retention in ER lumen (GO:0006621)2.76641413
93regulation of monocyte chemotaxis (GO:0090025)2.75519436
94negative regulation of adherens junction organization (GO:1903392)2.75430251
95negative regulation of focal adhesion assembly (GO:0051895)2.75430251
96negative regulation of cell junction assembly (GO:1901889)2.75430251
97positive regulation of endothelial cell apoptotic process (GO:2000353)2.74655695
98maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.73021204
99endothelial cell morphogenesis (GO:0001886)2.72780619
100erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.71481146
101L-phenylalanine metabolic process (GO:0006558)2.71481146
102tooth mineralization (GO:0034505)2.69298588
103regulation of extracellular matrix disassembly (GO:0010715)2.69241870
104regulation of chemokine biosynthetic process (GO:0045073)2.68380751
105nitrogen cycle metabolic process (GO:0071941)2.66645463
106response to laminar fluid shear stress (GO:0034616)2.65624157
107kidney mesenchyme development (GO:0072074)2.65095488
108regulation of apoptotic process involved in morphogenesis (GO:1902337)2.63805092
109epoxygenase P450 pathway (GO:0019373)2.63631086
110ceramide catabolic process (GO:0046514)2.63562542
111L-phenylalanine catabolic process (GO:0006559)2.61956441
112erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.61956441
113positive regulation of extracellular matrix organization (GO:1903055)2.61892138
114cellular response to vitamin (GO:0071295)2.61264607
115sulfur amino acid catabolic process (GO:0000098)2.61090470
116amino sugar catabolic process (GO:0046348)2.60709798
117vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.60577811
118negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.60003224
119response to magnesium ion (GO:0032026)2.59311472
120dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.58745414
121regulation of cholesterol storage (GO:0010885)2.58428660
122regulation of smooth muscle cell migration (GO:0014910)2.58053731
123bone trabecula formation (GO:0060346)2.57743878
124regulation of phagocytosis (GO:0050764)2.56152362
125venous blood vessel morphogenesis (GO:0048845)2.55427906
126chondroitin sulfate catabolic process (GO:0030207)2.55350854
127chronic inflammatory response (GO:0002544)2.54676550
128positive regulation of phagocytosis (GO:0050766)2.54626931
129positive regulation of receptor recycling (GO:0001921)2.54255659
130regulation of collagen metabolic process (GO:0010712)2.54220957
131embryo implantation (GO:0007566)2.52882392
132positive regulation of cell adhesion mediated by integrin (GO:0033630)2.52246917
133response to thyroid hormone (GO:0097066)2.52088366
134oligosaccharide catabolic process (GO:0009313)2.51565904
135cytokine production involved in immune response (GO:0002367)2.50574826
136negative regulation of platelet activation (GO:0010544)2.48201358
137sphingolipid catabolic process (GO:0030149)2.47836635
138membrane lipid catabolic process (GO:0046466)2.47313484
139positive regulation of blood vessel endothelial cell migration (GO:0043536)2.47182355
140keratan sulfate catabolic process (GO:0042340)2.47118796
141protein hydroxylation (GO:0018126)2.46796147
142extracellular matrix organization (GO:0030198)2.45900806
143regulation of membrane protein ectodomain proteolysis (GO:0051043)2.45548312
144sphingosine metabolic process (GO:0006670)2.45373787
145extracellular structure organization (GO:0043062)2.44898958
146positive regulation of p38MAPK cascade (GO:1900745)2.44443840
147cellular response to thyroid hormone stimulus (GO:0097067)2.44311561
148positive regulation of wound healing (GO:0090303)2.43486719
149keratinocyte differentiation (GO:0030216)2.43202448
150fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.42957517
151positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.42274742
152cell-substrate junction assembly (GO:0007044)2.41794759
153epithelial cell-cell adhesion (GO:0090136)2.41700662
154extracellular regulation of signal transduction (GO:1900115)2.41411240
155detection of external biotic stimulus (GO:0098581)2.40754758
156regulation of mononuclear cell migration (GO:0071675)2.39341160
157protein targeting to plasma membrane (GO:0072661)2.38829187
158wound healing (GO:0042060)2.36587537
159phospholipid efflux (GO:0033700)2.33775852
160L-ascorbic acid metabolic process (GO:0019852)2.33755381
161extracellular matrix assembly (GO:0085029)2.33672763
162regulation of natural killer cell differentiation (GO:0032823)2.33538804
163lipoprotein metabolic process (GO:0042157)2.31988307
164high-density lipoprotein particle remodeling (GO:0034375)2.31737004
165membrane raft organization (GO:0031579)2.30830039
166bile acid biosynthetic process (GO:0006699)2.30674259
167wound healing, spreading of epidermal cells (GO:0035313)2.27968360
168aldehyde catabolic process (GO:0046185)2.25888687
169regulation of cholesterol homeostasis (GO:2000188)2.25824388
170glyoxylate metabolic process (GO:0046487)2.25210462
171positive regulation of fatty acid metabolic process (GO:0045923)2.24599582
172xenobiotic catabolic process (GO:0042178)2.24496645
173production of molecular mediator involved in inflammatory response (GO:0002532)2.24315201
174protein heterotrimerization (GO:0070208)2.23819117

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.88396931
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.85914436
3RARG_19884340_ChIP-ChIP_MEFs_Mouse4.62964767
4TRIM28_21343339_ChIP-Seq_HEK293_Human4.19557266
5RXR_22158963_ChIP-Seq_LIVER_Mouse3.67357587
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.45554808
7PPARA_22158963_ChIP-Seq_LIVER_Mouse3.23515201
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.13647323
9CLOCK_20551151_ChIP-Seq_293T_Human2.85649507
10LXR_22158963_ChIP-Seq_LIVER_Mouse2.85336596
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.72921070
12THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.38074716
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.23329330
14TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.22712505
15PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.19949190
16RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.13432503
17RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.12711687
18CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.11527163
19NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.94726608
20EGR1_23403033_ChIP-Seq_LIVER_Mouse1.94579032
21* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.90947676
22ESR1_21235772_ChIP-Seq_MCF-7_Human1.89322881
23TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88093529
24* ELK3_25401928_ChIP-Seq_HUVEC_Human1.84973195
25FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.84927913
26ESR2_21235772_ChIP-Seq_MCF-7_Human1.75273987
27Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.72618596
28IRF8_21731497_ChIP-ChIP_J774_Mouse1.68272396
29SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.60590419
30CJUN_26792858_Chip-Seq_BT549_Human1.59820099
31STAT6_21828071_ChIP-Seq_BEAS2B_Human1.59782446
32HIF1A_21447827_ChIP-Seq_MCF-7_Human1.57071431
33* LXR_22292898_ChIP-Seq_THP-1_Human1.54761339
34SMAD_19615063_ChIP-ChIP_OVARY_Human1.53196610
35RACK7_27058665_Chip-Seq_MCF-7_Human1.49058504
36WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.46898108
37SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.46561520
38MYB_21317192_ChIP-Seq_ERMYB_Mouse1.45578185
39EGR1_19374776_ChIP-ChIP_THP-1_Human1.44734482
40IRF8_27001747_Chip-Seq_BMDM_Mouse1.43365378
41* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.42873225
42CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.40133061
43SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.37233201
44SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.37233201
45ESR1_15608294_ChIP-ChIP_MCF-7_Human1.36341097
46P63_26484246_Chip-Seq_KERATINOCYTES_Human1.35896851
47FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.35480698
48SOX2_20726797_ChIP-Seq_SW620_Human1.35064790
49GATA2_21666600_ChIP-Seq_HMVEC_Human1.30682096
50KDM2B_26808549_Chip-Seq_K562_Human1.29717625
51ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.28653506
52PPAR_26484153_Chip-Seq_NCI-H1993_Human1.26821531
53TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.26131376
54ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.25429377
55ATF3_27146783_Chip-Seq_COLON_Human1.25010345
56* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.24706800
57* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.24706800
58BRD4_27068464_Chip-Seq_AML-cells_Mouse1.23666792
59SMC3_22415368_ChIP-Seq_MEFs_Mouse1.23044167
60ZNF263_19887448_ChIP-Seq_K562_Human1.22497431
61JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21105952
62ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.20573525
63CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.19724940
64SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.19719271
65STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.19132719
66KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.18636529
67KDM2B_26808549_Chip-Seq_SUP-B15_Human1.16574706
68FOXO3_23340844_ChIP-Seq_DLD1_Human1.14925060
69VDR_24763502_ChIP-Seq_THP-1_Human1.14347854
70STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.13192412
71KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10736446
72IRF8_22096565_ChIP-ChIP_GC-B_Human1.10144058
73UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.10108608
74JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09760722
75SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06740886
76TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06728102
77* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06541252
78CTCF_27219007_Chip-Seq_ERYTHROID_Human1.05598446
79TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03222863
80SMC1_22415368_ChIP-Seq_MEFs_Mouse1.03101032
81NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.02808153
82* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.02776396
83P300_27058665_Chip-Seq_ZR-75-30cells_Human1.02212472
84BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01502855
85SA1_22415368_ChIP-Seq_MEFs_Mouse1.01461523
86CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.01153714
87TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00183414
88STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.99970795
89NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.99759461
90VDR_21846776_ChIP-Seq_THP-1_Human0.99402020
91TP53_23651856_ChIP-Seq_MEFs_Mouse0.99349709
92SOX2_27498859_Chip-Seq_STOMACH_Mouse0.99040787
93ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.98021599
94SPI1_23127762_ChIP-Seq_K562_Human0.97773718
95CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.97721091
96PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97324201
97* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.97070791
98TBX20_22080862_ChIP-Seq_HEART_Mouse0.96510285
99TBX20_22328084_ChIP-Seq_HEART_Mouse0.96510285
100UBF1/2_26484160_Chip-Seq_HMECs_Human0.93541346
101GATA1_19941826_ChIP-Seq_K562_Human0.93434908
102MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.93412077
103WT1_19549856_ChIP-ChIP_CCG9911_Human0.93393630
104KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.93233455
105SALL4_18804426_ChIP-ChIP_XEN_Mouse0.92980273
106RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.92426964
107VDR_24787735_ChIP-Seq_THP-1_Human0.92406506
108TP53_22127205_ChIP-Seq_IMR90_Human0.91753580
109SA1_27219007_Chip-Seq_ERYTHROID_Human0.91735699
110* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.91053223
111EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.90966507
112SRY_22984422_ChIP-ChIP_TESTIS_Rat0.89627211
113NFIB_24661679_ChIP-Seq_LUNG_Mouse0.89456192
114TP53_18474530_ChIP-ChIP_U2OS_Human0.87977312
115STAT3_1855785_ChIP-Seq_MESCs_Mouse0.87954104
116TFEB_21752829_ChIP-Seq_HELA_Human0.87609524
117* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86829927
118STAT4_19710469_ChIP-ChIP_TH1__Mouse0.86479631
119BRD4_25478319_ChIP-Seq_HGPS_Human0.86344998
120CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.86337544
121NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.85675335
122TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.83435656
123IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.82499254
124EGR1_19032775_ChIP-ChIP_M12_Human0.82236189
125KDM2B_26808549_Chip-Seq_DND41_Human0.81159961
126HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.81071219
127TP53_16413492_ChIP-PET_HCT116_Human0.79693986
128EP300_21415370_ChIP-Seq_HL-1_Mouse0.79532981
129HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.79067938
130PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.79038284
131FOXA2_19822575_ChIP-Seq_HepG2_Human0.78799365

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.81345268
2MP0003705_abnormal_hypodermis_morpholog4.66918381
3MP0005275_abnormal_skin_tensile3.73315535
4MP0005257_abnormal_intraocular_pressure3.26235454
5MP0003279_aneurysm2.86219187
6MP0005503_abnormal_tendon_morphology2.62130238
7MP0005360_urolithiasis2.59298659
8MP0009840_abnormal_foam_cell2.46009593
9MP0003566_abnormal_cell_adhesion2.36171026
10MP0001958_emphysema2.34057817
11MP0010368_abnormal_lymphatic_system2.32128572
12MP0005023_abnormal_wound_healing2.24929476
13MP0002139_abnormal_hepatobiliary_system2.21480751
14MP0005058_abnormal_lysosome_morphology2.13466776
15MP0003436_decreased_susceptibility_to2.08053936
16MP0003806_abnormal_nucleotide_metabolis2.06841117
17MP0009384_cardiac_valve_regurgitation2.03016244
18MP0004272_abnormal_basement_membrane1.98668588
19MP0005365_abnormal_bile_salt1.85993846
20MP0001533_abnormal_skeleton_physiology1.84230761
21MP0002060_abnormal_skin_morphology1.81027736
22MP0003172_abnormal_lysosome_physiology1.80464706
23MP0006082_CNS_inflammation1.77874037
24MP0003724_increased_susceptibility_to1.76079335
25MP0002138_abnormal_hepatobiliary_system1.66808026
26MP0006054_spinal_hemorrhage1.65900897
27MP0005085_abnormal_gallbladder_physiolo1.64500217
28MP0008875_abnormal_xenobiotic_pharmacok1.59958332
29MP0010352_gastrointestinal_tract_polyps1.54509529
30MP0010234_abnormal_vibrissa_follicle1.52163383
31MP0000751_myopathy1.50419098
32MP0002295_abnormal_pulmonary_circulatio1.47453971
33MP0003252_abnormal_bile_duct1.45141046
34MP0003191_abnormal_cellular_cholesterol1.39702837
35MP0004947_skin_inflammation1.38542099
36MP0000343_altered_response_to1.36931986
37MP0005171_absent_coat_pigmentation1.35652920
38MP0010329_abnormal_lipoprotein_level1.34607142
39MP0005390_skeleton_phenotype1.31903083
40MP0000767_abnormal_smooth_muscle1.30043538
41MP0003300_gastrointestinal_ulcer1.28798642
42MP0001243_abnormal_dermal_layer1.26544644
43MP0003075_altered_response_to1.25861658
44MP0003091_abnormal_cell_migration1.25220018
45MP0002933_joint_inflammation1.24471538
46MP0005083_abnormal_biliary_tract1.23548816
47MP0002419_abnormal_innate_immunity1.18909215
48MP0005451_abnormal_body_composition1.16810283
49MP0005332_abnormal_amino_acid1.12938871
50MP0000249_abnormal_blood_vessel1.12061922
51MP0005508_abnormal_skeleton_morphology1.11502502
52MP0005464_abnormal_platelet_physiology1.10910893
53MP0005623_abnormal_meninges_morphology1.10543672
54MP0004858_abnormal_nervous_system1.09854783
55MP0003303_peritoneal_inflammation1.06804446
56MP0000609_abnormal_liver_physiology1.03291674
57MP0000685_abnormal_immune_system1.03285902
58MP0005501_abnormal_skin_physiology1.03095383
59MP0001849_ear_inflammation1.02859222
60MP0005387_immune_system_phenotype1.02278927
61MP0001790_abnormal_immune_system1.02278927
62MP0000604_amyloidosis1.01914769
63MP0009764_decreased_sensitivity_to1.01382118
64MP0005319_abnormal_enzyme/_coenzyme0.99305349
65MP0009053_abnormal_anal_canal0.99123125
66MP0001851_eye_inflammation0.98029811
67MP0001542_abnormal_bone_strength0.97353265
68MP0005025_abnormal_response_to0.95064136
69MP0003828_pulmonary_edema0.93858516
70MP0002168_other_aberrant_phenotype0.93232449
71MP0005164_abnormal_response_to0.92380389
72MP0003195_calcinosis0.92187871
73MP0002998_abnormal_bone_remodeling0.91829127
74MP0003453_abnormal_keratinocyte_physiol0.91707415
75MP0002108_abnormal_muscle_morphology0.90790969
76MP0002254_reproductive_system_inflammat0.90747971
77MP0003186_abnormal_redox_activity0.90495823
78MP0001879_abnormal_lymphatic_vessel0.89845003
79MP0001915_intracranial_hemorrhage0.89338847
80MP0008260_abnormal_autophagy0.89149022
81MP0002796_impaired_skin_barrier0.88446053
82MP0003941_abnormal_skin_development0.87459353
83MP0003795_abnormal_bone_structure0.86201625
84MP0005165_increased_susceptibility_to0.85959423
85MP0003448_altered_tumor_morphology0.85387226
86MP0002148_abnormal_hypersensitivity_rea0.84638013
87MP0002166_altered_tumor_susceptibility0.83927097
88MP0009763_increased_sensitivity_to0.83599655
89MP0009643_abnormal_urine_homeostasis0.82988429
90MP0002896_abnormal_bone_mineralization0.82720274
91MP0000750_abnormal_muscle_regeneration0.82565741
92MP0000013_abnormal_adipose_tissue0.82238970
93MP0002118_abnormal_lipid_homeostasis0.82021692
94MP0008004_abnormal_stomach_pH0.81548011
95MP0004883_abnormal_blood_vessel0.81110452
96MP0000858_altered_metastatic_potential0.80886167
97MP0005409_darkened_coat_color0.79161661
98MP0008469_abnormal_protein_level0.79022641
99MP0004019_abnormal_vitamin_homeostasis0.78707230
100MP0009785_altered_susceptibility_to0.78151632
101MP0005000_abnormal_immune_tolerance0.77323271
102MP0009278_abnormal_bone_marrow0.76965651
103MP0000733_abnormal_muscle_development0.76933762
104MP0010030_abnormal_orbit_morphology0.76530540
105MP0002282_abnormal_trachea_morphology0.76394039
106MP0002128_abnormal_blood_circulation0.76191998
107MP0000467_abnormal_esophagus_morphology0.76164771
108MP0009333_abnormal_splenocyte_physiolog0.76134180
109MP0000749_muscle_degeneration0.75828093
110MP0001845_abnormal_inflammatory_respons0.75757499
111MP0001614_abnormal_blood_vessel0.75631047
112MP0004510_myositis0.75496121
113MP0009780_abnormal_chondrocyte_physiolo0.74979243
114MP0002877_abnormal_melanocyte_morpholog0.74979175
115MP0003950_abnormal_plasma_membrane0.74746876
116MP0005595_abnormal_vascular_smooth0.74508091
117MP0005197_abnormal_uvea_morphology0.74248545
118MP0001853_heart_inflammation0.72846365
119MP0001216_abnormal_epidermal_layer0.72780552
120MP0002136_abnormal_kidney_physiology0.72260498
121MP0010386_abnormal_urinary_bladder0.72213791
122MP0000371_diluted_coat_color0.71848464
123MP0000598_abnormal_liver_morphology0.71700775
124MP0000759_abnormal_skeletal_muscle0.71618442
125MP0010771_integument_phenotype0.71561990
126MP0000920_abnormal_myelination0.71067421
127MP0005584_abnormal_enzyme/coenzyme_acti0.70353964
128MP0002405_respiratory_system_inflammati0.69457067
129MP0001299_abnormal_eye_distance/0.68098577
130MP0002113_abnormal_skeleton_development0.67549652
131MP0003634_abnormal_glial_cell0.66360717
132MP0009250_abnormal_appendicular_skeleto0.65299755
133MP0000163_abnormal_cartilage_morphology0.65155115
134MP0005166_decreased_susceptibility_to0.63783316
135MP0000003_abnormal_adipose_tissue0.63055431
136MP0000747_muscle_weakness0.59191286
137MP0005193_abnormal_anterior_eye0.58917615
138MP0002089_abnormal_postnatal_growth/wei0.57198181

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.61768221
2Systemic lupus erythematosus (HP:0002725)6.03645696
3Abnormality of glycolipid metabolism (HP:0010969)4.96456594
4Abnormality of liposaccharide metabolism (HP:0010968)4.96456594
5Abnormality of glycosphingolipid metabolism (HP:0004343)4.96456594
6Premature rupture of membranes (HP:0001788)4.82950491
7Abnormality of complement system (HP:0005339)4.64206299
8Complement deficiency (HP:0004431)4.63651197
9Peritonitis (HP:0002586)4.47707814
10Vertebral compression fractures (HP:0002953)4.28175039
11Deep venous thrombosis (HP:0002625)4.22652055
12Glomerulonephritis (HP:0000099)4.15732912
13Shallow orbits (HP:0000586)4.11763324
14Follicular hyperkeratosis (HP:0007502)3.86921004
15Cerebral aneurysm (HP:0004944)3.65621280
16Cervical subluxation (HP:0003308)3.58857645
17Atrophic scars (HP:0001075)3.55867897
18Aortic aneurysm (HP:0004942)3.55148809
19Broad metatarsal (HP:0001783)3.52261626
20Aortic dissection (HP:0002647)3.41969393
21Vascular tortuosity (HP:0004948)3.34064831
22Spondylolisthesis (HP:0003302)3.28865264
23Arterial tortuosity (HP:0005116)3.27915243
24Dysostosis multiplex (HP:0000943)3.21316171
25Vacuolated lymphocytes (HP:0001922)3.13650894
26Nuclear cataract (HP:0100018)3.10091518
27Slender build (HP:0001533)3.07830208
28Nephritis (HP:0000123)3.06555326
29Xanthomatosis (HP:0000991)3.05193064
30Biconcave vertebral bodies (HP:0004586)3.04346994
31Joint stiffness (HP:0001387)3.03498850
32Abnormality of monocarboxylic acid metabolism (HP:0010996)2.92850409
33Mitral stenosis (HP:0001718)2.91410689
34Wrist flexion contracture (HP:0001239)2.88264188
35Achilles tendon contracture (HP:0001771)2.84536053
36Urinary glycosaminoglycan excretion (HP:0003541)2.81918119
37Mucopolysacchariduria (HP:0008155)2.81918119
38Abnormality of the common coagulation pathway (HP:0010990)2.80619170
39Short nail (HP:0001799)2.67770310
40Dilatation of the ascending aorta (HP:0005111)2.65931559
41Wormian bones (HP:0002645)2.65148905
42Beaking of vertebral bodies (HP:0004568)2.61891861
43Fragile skin (HP:0001030)2.60984601
44Prolonged partial thromboplastin time (HP:0003645)2.60632224
45Abnormality of polysaccharide metabolism (HP:0011012)2.59994882
46Abnormality of glycosaminoglycan metabolism (HP:0004371)2.59994882
47Abnormality of mucopolysaccharide metabolism (HP:0011020)2.59994882
48Asymmetric septal hypertrophy (HP:0001670)2.58889785
49Recurrent gram-negative bacterial infections (HP:0005420)2.57275665
50Coxa vara (HP:0002812)2.55201271
51Increased connective tissue (HP:0009025)2.54326637
52Soft skin (HP:0000977)2.53533730
53Abnormality of the Achilles tendon (HP:0005109)2.53000958
54Mildly elevated creatine phosphokinase (HP:0008180)2.51904039
55Aneurysm (HP:0002617)2.51866613
56Increased variability in muscle fiber diameter (HP:0003557)2.50730712
57Blue sclerae (HP:0000592)2.46998097
58Neonatal short-limb short stature (HP:0008921)2.45422248
59Myocardial infarction (HP:0001658)2.43199113
60Hand muscle atrophy (HP:0009130)2.40698663
61Right ventricular cardiomyopathy (HP:0011663)2.37744154
62Distal upper limb amyotrophy (HP:0007149)2.36949031
63Upper limb amyotrophy (HP:0009129)2.36949031
64Cardiovascular calcification (HP:0011915)2.35614373
65Abnormality of the acetabulum (HP:0003170)2.34995641
66Spinal rigidity (HP:0003306)2.31408653
67Menorrhagia (HP:0000132)2.30761445
68Generalized amyotrophy (HP:0003700)2.30292116
69Abnormality of skeletal muscle fiber size (HP:0012084)2.27639847
70Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.26417612
71Ectopia lentis (HP:0001083)2.25992590
72Osteolytic defects of the phalanges of the hand (HP:0009771)2.22788480
73Osteolytic defects of the hand bones (HP:0009699)2.22788480
74Ankle contracture (HP:0006466)2.22714855
75Joint hemorrhage (HP:0005261)2.20598584
76Abnormality of dentin (HP:0010299)2.18750257
77Hypoalphalipoproteinemia (HP:0003233)2.17431445
78Bladder diverticulum (HP:0000015)2.15754307
79Amyloidosis (HP:0011034)2.14450009
80Bowel diverticulosis (HP:0005222)2.11434180
81Mitral valve prolapse (HP:0001634)2.09768746
82Joint laxity (HP:0001388)2.08933313
83Esophageal varix (HP:0002040)2.08889163
84Bronchomalacia (HP:0002780)2.08573360
85Distal lower limb amyotrophy (HP:0008944)2.08540687
86Natal tooth (HP:0000695)2.07933174
87Axonal loss (HP:0003447)2.06655452
88Mitral regurgitation (HP:0001653)2.05593729
89Intrahepatic cholestasis (HP:0001406)2.04008491
90Hyperextensible skin (HP:0000974)2.00825234
91Long toe (HP:0010511)1.99492360
92Aortic regurgitation (HP:0001659)1.98169316
93Loss of speech (HP:0002371)1.97399800
94Abnormality of aromatic amino acid family metabolism (HP:0004338)1.95163860
95Neurofibrillary tangles (HP:0002185)1.95021590
96Vascular calcification (HP:0004934)1.91276578
97Aortic valve stenosis (HP:0001650)1.91143935
98J-shaped sella turcica (HP:0002680)1.90149487
99Abnormal delivery (HP:0001787)1.87765091
100Hypoventilation (HP:0002791)1.86643373
101Emphysema (HP:0002097)1.84320507
102Thin bony cortex (HP:0002753)1.84316957
103Ovoid vertebral bodies (HP:0003300)1.83586520
104Abnormality of the lumbar spine (HP:0100712)1.82415345
105Congenital ichthyosiform erythroderma (HP:0007431)1.79862847
106Abnormality of the peritoneum (HP:0002585)1.79248369
107Type 1 muscle fiber predominance (HP:0003803)1.78883284
108Eczematoid dermatitis (HP:0000976)1.77333465
109Overgrowth (HP:0001548)1.76818996
110Femoral bowing (HP:0002980)1.76641723
111Distal lower limb muscle weakness (HP:0009053)1.75746151
112Elbow flexion contracture (HP:0002987)1.74876186
113Ulnar deviation of the wrist (HP:0003049)1.74870919
114Hypolipoproteinemia (HP:0010981)1.74440430
115Abnormality of glutamine family amino acid metabolism (HP:0010902)1.74051826
116Nonimmune hydrops fetalis (HP:0001790)1.73094829
117Hyperlipoproteinemia (HP:0010980)1.72808075
118Flat acetabular roof (HP:0003180)1.70997750
119Increased neuronal autofluorescent lipopigment (HP:0002074)1.70997119
120Abnormality of the distal phalanges of the toes (HP:0010182)1.70359997
121Interstitial pulmonary disease (HP:0006530)1.69423332
122Polycythemia (HP:0001901)1.69403464
123Striae distensae (HP:0001065)1.68586042
124Round ear (HP:0100830)1.68549067
125Abnormality of the intrinsic pathway (HP:0010989)1.68545272
126Ulnar bowing (HP:0003031)1.67901007
127Disproportionate tall stature (HP:0001519)1.67616920
128Spontaneous hematomas (HP:0007420)1.67212660
129Abnormality of the vasculature of the conjunctiva (HP:0008054)1.66659075
130Hyperacusis (HP:0010780)1.66333672
131Turricephaly (HP:0000262)1.64925593
132Camptodactyly of toe (HP:0001836)1.64644842
133Osteopenia (HP:0000938)1.63950027
134Genu recurvatum (HP:0002816)1.63654781
135Progressive neurologic deterioration (HP:0002344)1.62256818
136Increased cerebral lipofuscin (HP:0011813)1.62217892
137Thoracolumbar scoliosis (HP:0002944)1.61398985

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.99151228
2MST1R4.34684035
3TRIB33.57914770
4EPHA23.41012312
5IRAK33.05670347
6PKN22.63607254
7TTN2.51420816
8TGFBR22.37682310
9MET2.28057690
10GRK72.08369356
11EPHB12.03867778
12EPHB22.01223218
13BLK2.01197122
14RIPK11.98054568
15BMX1.81767226
16FGFR41.78329978
17PIM21.76583778
18LATS21.63644756
19CDC42BPA1.62548919
20TRPM71.61453977
21PTK61.61043649
22SIK11.56129261
23ARAF1.54834786
24PTK21.52155010
25TESK11.46417946
26MAP3K31.45343543
27CAMK1D1.44379206
28LRRK21.41884955
29MAP3K111.38828605
30TYK21.38790797
31MAP2K31.37568704
32PRKD21.35991650
33FER1.31807322
34NME21.31352073
35MAPKAPK31.29415817
36PDGFRA1.28827820
37TBK11.28150707
38DDR21.24480583
39EPHA31.23338889
40MAP3K61.18445735
41ICK1.18245026
42STK101.16076713
43KDR1.14107209
44TAOK31.13459693
45RPS6KA41.13304093
46PIK3CG1.12276166
47ZAP701.11198815
48PRPF4B1.06640175
49FLT31.06208647
50TGFBR11.05432357
51BCKDK1.03826792
52LIMK11.02391594
53PTK2B0.99293134
54ERBB30.96682695
55CSK0.96619472
56STK380.92398303
57PAK40.91322368
58NEK90.89187476
59FGFR10.88153870
60ERBB40.87277932
61PAK20.86338444
62FRK0.83677437
63MAP4K10.83613403
64CAMK1G0.77962941
65PRKG20.77595309
66HCK0.77543766
67KIT0.76360279
68PAK30.76257081
69RPS6KA20.75176693
70DAPK30.74306735
71MAP3K120.74007420
72JAK10.72970999
73LMTK20.72188169
74JAK30.71549252
75LATS10.69625796
76MYLK0.69516692
77MAP2K10.69287132
78MOS0.68094746
79PAK10.67561081
80PAK60.66316112
81ABL20.66111081
82MAPK70.65027411
83NTRK10.64111763
84DMPK0.62779665
85DAPK20.62228394
86KSR20.62133477
87IGF1R0.61703132
88MAP3K20.60694548
89ADRBK20.60600336
90TAOK10.59864466
91ROCK20.59549040
92CDK60.59493433
93PRKCH0.58628744
94PRKD10.57619210
95EEF2K0.57588152
96ADRBK10.57212831
97MUSK0.56019138
98MAP3K70.53981166
99TAOK20.53300906
100MAP3K140.53232196
101MAP3K130.52321850
102SIK30.52286178
103CLK10.51325504
104STK30.51112099
105DYRK1B0.50620460
106MATK0.49223488
107GRK50.48632260
108EGFR0.48532655
109BRAF0.47203443
110TESK20.46136198
111MAP3K10.43920775
112ERBB20.43888145
113IKBKB0.42947590
114TIE10.41279697
115MAP3K80.39722774
116MAP3K50.39369547
117CAMKK10.38898887
118MAPKAPK20.38809172
119PIK3CA0.38139566
120CHUK0.37674633
121ILK0.37202546
122CAMK2G0.36403689
123GRK60.36304852
124RET0.35823635
125SRC0.35701368
126ROCK10.35222341
127MTOR0.35160722
128PDGFRB0.34814250
129PRKD30.34325819
130MAPK120.33234233
131MARK20.33001760
132PDPK10.32936244
133JAK20.31172795
134CDK150.30775980
135GSK3A0.29372023
136INSR0.29202432
137CDK11A0.29051632
138CDK140.28399539

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051504.66048473
2Complement and coagulation cascades_Homo sapiens_hsa046103.86246329
3Other glycan degradation_Homo sapiens_hsa005112.81847269
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.45557157
5Caffeine metabolism_Homo sapiens_hsa002322.41600183
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.37694557
7Glycosaminoglycan degradation_Homo sapiens_hsa005312.28676605
8Arginine biosynthesis_Homo sapiens_hsa002202.07973322
9Nitrogen metabolism_Homo sapiens_hsa009101.99481351
10Malaria_Homo sapiens_hsa051441.99202297
11Pentose and glucuronate interconversions_Homo sapiens_hsa000401.94556858
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.84817360
13Pertussis_Homo sapiens_hsa051331.83431864
14ECM-receptor interaction_Homo sapiens_hsa045121.79641153
15Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.75350537
16Rheumatoid arthritis_Homo sapiens_hsa053231.74300851
17Vibrio cholerae infection_Homo sapiens_hsa051101.67688513
18Fatty acid degradation_Homo sapiens_hsa000711.65835205
19Chemical carcinogenesis_Homo sapiens_hsa052041.55049044
20Lysosome_Homo sapiens_hsa041421.53006047
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.52911471
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.44394796
23PPAR signaling pathway_Homo sapiens_hsa033201.42317695
24Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.42214526
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.41036965
26Tryptophan metabolism_Homo sapiens_hsa003801.40768238
27Amoebiasis_Homo sapiens_hsa051461.40361471
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.40183113
29Histidine metabolism_Homo sapiens_hsa003401.26523486
30Sphingolipid metabolism_Homo sapiens_hsa006001.26282521
31Leishmaniasis_Homo sapiens_hsa051401.24515219
32Prion diseases_Homo sapiens_hsa050201.24282762
33Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.20469070
34Focal adhesion_Homo sapiens_hsa045101.18037539
35Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.17202830
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.16820674
37Proteoglycans in cancer_Homo sapiens_hsa052051.12671055
38Protein digestion and absorption_Homo sapiens_hsa049741.10231140
39NF-kappa B signaling pathway_Homo sapiens_hsa040641.07159834
40Fatty acid metabolism_Homo sapiens_hsa012121.05954354
41Starch and sucrose metabolism_Homo sapiens_hsa005001.05867794
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.05369323
43Steroid hormone biosynthesis_Homo sapiens_hsa001401.05249364
44Arachidonic acid metabolism_Homo sapiens_hsa005901.03610053
45Sulfur metabolism_Homo sapiens_hsa009201.00822761
46Phenylalanine metabolism_Homo sapiens_hsa003601.00077184
47Phagosome_Homo sapiens_hsa041450.96159480
48Peroxisome_Homo sapiens_hsa041460.95179589
49beta-Alanine metabolism_Homo sapiens_hsa004100.92809489
50Bile secretion_Homo sapiens_hsa049760.92654731
51AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.92270526
52Shigellosis_Homo sapiens_hsa051310.91783992
53Endocytosis_Homo sapiens_hsa041440.90123709
54Bladder cancer_Homo sapiens_hsa052190.88707910
55Legionellosis_Homo sapiens_hsa051340.85979260
56Leukocyte transendothelial migration_Homo sapiens_hsa046700.85868898
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.85808234
58Adherens junction_Homo sapiens_hsa045200.83428069
59Acute myeloid leukemia_Homo sapiens_hsa052210.82283841
60Small cell lung cancer_Homo sapiens_hsa052220.81405637
61Toxoplasmosis_Homo sapiens_hsa051450.80895221
62SNARE interactions in vesicular transport_Homo sapiens_hsa041300.80699506
63Glutathione metabolism_Homo sapiens_hsa004800.79341305
642-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.79287148
65Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.79156408
66Retinol metabolism_Homo sapiens_hsa008300.77960301
67Collecting duct acid secretion_Homo sapiens_hsa049660.77743009
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.76763889
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76722172
70African trypanosomiasis_Homo sapiens_hsa051430.76680575
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.75565978
72Influenza A_Homo sapiens_hsa051640.75144497
73RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.74243578
74Hepatitis B_Homo sapiens_hsa051610.73189203
75Arginine and proline metabolism_Homo sapiens_hsa003300.72235143
76VEGF signaling pathway_Homo sapiens_hsa043700.71427200
77Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.70042462
78Hepatitis C_Homo sapiens_hsa051600.69995212
79Pancreatic cancer_Homo sapiens_hsa052120.69993699
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.69930440
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68886172
82Melanoma_Homo sapiens_hsa052180.68853276
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.68841400
84Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.68713327
85Tyrosine metabolism_Homo sapiens_hsa003500.67868105
86Dilated cardiomyopathy_Homo sapiens_hsa054140.66316880
87Osteoclast differentiation_Homo sapiens_hsa043800.66160338
88Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.65924591
89Propanoate metabolism_Homo sapiens_hsa006400.65276477
90Tuberculosis_Homo sapiens_hsa051520.65177171
91NOD-like receptor signaling pathway_Homo sapiens_hsa046210.64543157
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63600287
93Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.63583465
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.63239705
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62847632
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.62054155
97Renal cell carcinoma_Homo sapiens_hsa052110.61492944
98Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.60683204
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60139117
100Biosynthesis of amino acids_Homo sapiens_hsa012300.59739386
101Salmonella infection_Homo sapiens_hsa051320.59492701
102Pyruvate metabolism_Homo sapiens_hsa006200.59327107
103Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59321416
104Fructose and mannose metabolism_Homo sapiens_hsa000510.58855148
105MicroRNAs in cancer_Homo sapiens_hsa052060.58486472
106Glioma_Homo sapiens_hsa052140.58062039
107TNF signaling pathway_Homo sapiens_hsa046680.57442388
108Platelet activation_Homo sapiens_hsa046110.55874730
109Pathways in cancer_Homo sapiens_hsa052000.55823079
110Carbon metabolism_Homo sapiens_hsa012000.55487356
111Asthma_Homo sapiens_hsa053100.55084042
112Viral myocarditis_Homo sapiens_hsa054160.54264173
113Lysine degradation_Homo sapiens_hsa003100.51857852
114Hematopoietic cell lineage_Homo sapiens_hsa046400.51801694
115Adipocytokine signaling pathway_Homo sapiens_hsa049200.51494742
116N-Glycan biosynthesis_Homo sapiens_hsa005100.51362351
117ABC transporters_Homo sapiens_hsa020100.51334577
118Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51209756
119Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.50386207
120Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50190913
121Vitamin digestion and absorption_Homo sapiens_hsa049770.49583331
122Prostate cancer_Homo sapiens_hsa052150.49415170
123Butanoate metabolism_Homo sapiens_hsa006500.49157401
124Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.48589393
125GnRH signaling pathway_Homo sapiens_hsa049120.48554956
126Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47779745
127Notch signaling pathway_Homo sapiens_hsa043300.47228980
128Prolactin signaling pathway_Homo sapiens_hsa049170.46377588
129Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46230215
130Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.46080581
131Chronic myeloid leukemia_Homo sapiens_hsa052200.45756281
132Apoptosis_Homo sapiens_hsa042100.44378032
133PI3K-Akt signaling pathway_Homo sapiens_hsa041510.44141186
134Insulin resistance_Homo sapiens_hsa049310.44131840
135Toll-like receptor signaling pathway_Homo sapiens_hsa046200.44050779
136Linoleic acid metabolism_Homo sapiens_hsa005910.43920791
137Selenocompound metabolism_Homo sapiens_hsa004500.43575098
138Mineral absorption_Homo sapiens_hsa049780.43212330
139HTLV-I infection_Homo sapiens_hsa051660.42840924
140Synaptic vesicle cycle_Homo sapiens_hsa047210.41259363
141Sulfur relay system_Homo sapiens_hsa041220.40233626
142Allograft rejection_Homo sapiens_hsa053300.39835077
143TGF-beta signaling pathway_Homo sapiens_hsa043500.39774859
144Galactose metabolism_Homo sapiens_hsa000520.39587408
145Gap junction_Homo sapiens_hsa045400.39310874
146Fat digestion and absorption_Homo sapiens_hsa049750.38846971
147Renin-angiotensin system_Homo sapiens_hsa046140.38804926
148Pentose phosphate pathway_Homo sapiens_hsa000300.38593601
149Rap1 signaling pathway_Homo sapiens_hsa040150.38236098
150Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38076652
151Thyroid cancer_Homo sapiens_hsa052160.37193890

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