ECM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: ECM2 encodes extracellular matrix protein 2, so named because it shares extensive similarity with known extracelluar matrix proteins. Three transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1triglyceride catabolic process (GO:0019433)5.99619654
2low-density lipoprotein particle clearance (GO:0034383)5.97222633
3peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)5.42149479
4neutral lipid catabolic process (GO:0046461)5.38601214
5acylglycerol catabolic process (GO:0046464)5.38601214
6regulation of sequestering of triglyceride (GO:0010889)5.37585020
7keratan sulfate catabolic process (GO:0042340)5.17152712
8ethanol oxidation (GO:0006069)4.58340606
9extracellular fibril organization (GO:0043206)4.35021534
10protein heterotrimerization (GO:0070208)4.31431788
11complement activation, alternative pathway (GO:0006957)4.24100423
12transcytosis (GO:0045056)4.15992952
13glomerulus development (GO:0032835)4.14571051
14retina vasculature morphogenesis in camera-type eye (GO:0061299)4.14107847
15ovulation from ovarian follicle (GO:0001542)4.07293826
16peripheral nervous system axon ensheathment (GO:0032292)4.01633114
17myelination in peripheral nervous system (GO:0022011)4.01633114
18smooth muscle tissue development (GO:0048745)3.84957369
19collagen fibril organization (GO:0030199)3.80995685
20glycerolipid catabolic process (GO:0046503)3.78773496
21dermatan sulfate biosynthetic process (GO:0030208)3.73286818
22response to dietary excess (GO:0002021)3.73169686
23ethanol metabolic process (GO:0006067)3.66403222
24regulation of gonadotropin secretion (GO:0032276)3.64419928
25kidney mesenchyme development (GO:0072074)3.61741351
26polyol transport (GO:0015791)3.58420250
27fibril organization (GO:0097435)3.57910837
28lymph vessel development (GO:0001945)3.53507645
29dermatan sulfate metabolic process (GO:0030205)3.51462807
30positive regulation of respiratory burst (GO:0060267)3.49740453
31fatty acid homeostasis (GO:0055089)3.49420299
32extracellular matrix assembly (GO:0085029)3.47607802
33venous blood vessel morphogenesis (GO:0048845)3.47159311
34endocardial cushion morphogenesis (GO:0003203)3.45414079
35negative regulation of cardiac muscle hypertrophy (GO:0010614)3.41632327
36triglyceride homeostasis (GO:0070328)3.40623351
37acylglycerol homeostasis (GO:0055090)3.40623351
38positive regulation of macrophage derived foam cell differentiation (GO:0010744)3.40585591
39glomerular basement membrane development (GO:0032836)3.40355600
40plasma lipoprotein particle clearance (GO:0034381)3.39831652
41primary alcohol metabolic process (GO:0034308)3.33487640
42mesenchyme morphogenesis (GO:0072132)3.33467986
43negative regulation of gluconeogenesis (GO:0045721)3.33427581
44detection of molecule of bacterial origin (GO:0032490)3.32545577
45cell migration involved in heart development (GO:0060973)3.32268550
46sequestering of extracellular ligand from receptor (GO:0035581)3.31471035
47regulation of lipoprotein metabolic process (GO:0050746)3.29469199
48lipid storage (GO:0019915)3.29233594
49triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.28413059
50positive regulation of triglyceride lipase activity (GO:0061365)3.27441514
51positive regulation of lipoprotein lipase activity (GO:0051006)3.27441514
52NADH metabolic process (GO:0006734)3.26835593
53positive regulation of macrophage cytokine production (GO:0060907)3.25520562
54positive regulation of cholesterol efflux (GO:0010875)3.23833711
55positive regulation of glycolytic process (GO:0045821)3.23649265
56regulation of cardiac muscle cell differentiation (GO:2000725)3.23213879
57negative regulation of muscle hypertrophy (GO:0014741)3.22281455
58myofibril assembly (GO:0030239)3.19741628
59cell proliferation involved in kidney development (GO:0072111)3.17146133
60negative regulation of complement activation (GO:0045916)3.16637002
61bone trabecula formation (GO:0060346)3.14279044
62negative regulation of protein activation cascade (GO:2000258)3.12925000
63protein localization to cell surface (GO:0034394)3.12164537
64positive regulation of glomerulus development (GO:0090193)3.10875448
65negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.10812915
66regulation of triglyceride catabolic process (GO:0010896)3.09908917
67regulation of macrophage derived foam cell differentiation (GO:0010743)3.09790136
68regulation of protein activation cascade (GO:2000257)3.09563583
69regulation of cholesterol storage (GO:0010885)3.07271245
70regulation of complement activation (GO:0030449)3.06962702
71negative regulation of myoblast differentiation (GO:0045662)3.05532153
72barbed-end actin filament capping (GO:0051016)3.05313563
73cardiac myofibril assembly (GO:0055003)3.05122324
74cGMP-mediated signaling (GO:0019934)3.04549865
75positive regulation of sterol transport (GO:0032373)3.03770267
76positive regulation of cholesterol transport (GO:0032376)3.03770267
77atrioventricular valve morphogenesis (GO:0003181)3.03657121
78metanephric mesenchyme development (GO:0072075)3.03282217
79diacylglycerol metabolic process (GO:0046339)3.02038061
80blood vessel maturation (GO:0001955)3.00663704
81positive regulation of lipid storage (GO:0010884)2.99172987
82negative regulation of cartilage development (GO:0061037)2.98849091
83endocrine hormone secretion (GO:0060986)2.97434014
84regulation of pigment cell differentiation (GO:0050932)2.97042828
85negative regulation of smooth muscle cell migration (GO:0014912)2.95642513
86glomerular filtration (GO:0003094)2.92877512
87mesenchymal cell differentiation involved in kidney development (GO:0072161)2.90470262
88mesenchymal cell differentiation involved in renal system development (GO:2001012)2.90470262
89lipid particle organization (GO:0034389)2.90381184
90nucleoside diphosphate catabolic process (GO:0009134)2.89991634
91energy homeostasis (GO:0097009)2.88264400
92positive regulation of glucose import (GO:0046326)2.85638188
93brown fat cell differentiation (GO:0050873)2.85581891
94opsonization (GO:0008228)2.85095490
95cellular response to epinephrine stimulus (GO:0071872)2.84967746
96cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.84946615
97primary alcohol catabolic process (GO:0034310)2.84912122
98vascular endothelial growth factor signaling pathway (GO:0038084)2.84438573
99regulation of plasminogen activation (GO:0010755)2.84387351
100regulation of phospholipase A2 activity (GO:0032429)2.84238647
101chondroitin sulfate catabolic process (GO:0030207)2.82640670
102regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.82412052
103regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.81767481
104white fat cell differentiation (GO:0050872)2.81590921
105regulation of relaxation of muscle (GO:1901077)2.80676282
106regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.79355539
107negative regulation of norepinephrine secretion (GO:0010700)2.78655092
108regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.78226830
109skeletal muscle adaptation (GO:0043501)2.77244485
110negative regulation of granulocyte differentiation (GO:0030853)2.76375129
111positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.76310939
112regulation of macrophage cytokine production (GO:0010935)2.75799426
113response to phenylpropanoid (GO:0080184)2.75310105
114positive regulation of cellular response to insulin stimulus (GO:1900078)2.75181098
115regulation of interleukin-8 secretion (GO:2000482)2.75123798
116negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.74256918
117extracellular regulation of signal transduction (GO:1900115)2.73218725
118extracellular negative regulation of signal transduction (GO:1900116)2.73218725
119regulation of skeletal muscle contraction (GO:0014819)2.73024690
120negative regulation of protein autophosphorylation (GO:0031953)2.70780663
121regulation of cAMP-dependent protein kinase activity (GO:2000479)2.70632471
122negative regulation of Rho protein signal transduction (GO:0035024)2.70360586
123positive regulation of smooth muscle cell migration (GO:0014911)2.70070105
124regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)2.70053075
125positive regulation of endothelial cell apoptotic process (GO:2000353)2.69272007
126valine metabolic process (GO:0006573)2.66843254
127regulation of cardiac muscle hypertrophy (GO:0010611)2.66561774
128fatty acid transmembrane transport (GO:1902001)2.65829081
129complement activation (GO:0006956)2.65743555
130cellular response to vitamin (GO:0071295)2.63972942
131triglyceride metabolic process (GO:0006641)2.63460807
132epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.63074245
133regulation of muscle hypertrophy (GO:0014743)2.62175175
134cornea development in camera-type eye (GO:0061303)2.61925687
135collagen metabolic process (GO:0032963)2.60388544
136response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.59099190
137nephron tubule development (GO:0072080)2.58366067
138regulation of integrin-mediated signaling pathway (GO:2001044)2.55891395
139response to epinephrine (GO:0071871)2.55391871
140collagen catabolic process (GO:0030574)2.55175998
141response to folic acid (GO:0051593)2.54150829
142negative regulation of smooth muscle cell proliferation (GO:0048662)2.53367410
143virion attachment to host cell (GO:0019062)2.52834521
144adhesion of symbiont to host cell (GO:0044650)2.52834521
145cellular response to leptin stimulus (GO:0044320)2.52259309
146positive regulation of glucose transport (GO:0010828)2.52084386
147regulation of sterol transport (GO:0032371)2.51164490
148regulation of cholesterol transport (GO:0032374)2.51164490
149nephron epithelium development (GO:0072009)2.51030461
150retinol metabolic process (GO:0042572)2.50719156
151endothelium development (GO:0003158)2.50443892
152negative regulation of heart growth (GO:0061117)2.49530790
153negative regulation of cardiac muscle tissue growth (GO:0055022)2.49530790
154import into cell (GO:0098657)2.48866301
155cellular response to BMP stimulus (GO:0071773)2.48814890
156response to BMP (GO:0071772)2.48814890
157regulation of non-canonical Wnt signaling pathway (GO:2000050)2.47789935
158definitive hemopoiesis (GO:0060216)2.47088160
159cell differentiation involved in metanephros development (GO:0072202)2.46962602
160regulation of actin filament-based movement (GO:1903115)2.46386994
161multicellular organismal macromolecule metabolic process (GO:0044259)2.46258343
162regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.45924112
163keratan sulfate biosynthetic process (GO:0018146)2.45392826
164regulation of myoblast differentiation (GO:0045661)2.41574130
165superoxide anion generation (GO:0042554)2.38801635
166positive regulation of vascular permeability (GO:0043117)2.38399223
167regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.36334311
168artery development (GO:0060840)2.35948737
169mesonephros development (GO:0001823)2.35565775
170endothelial cell proliferation (GO:0001935)2.34769367
171regulation of skeletal muscle fiber development (GO:0048742)2.33782696
172multicellular organismal catabolic process (GO:0044243)2.33699074
173multicellular organismal metabolic process (GO:0044236)2.33425025
174* extracellular matrix organization (GO:0030198)2.33408930
175renal tubule development (GO:0061326)2.32982293
176* extracellular structure organization (GO:0043062)2.32508262
177chondrocyte proliferation (GO:0035988)2.32446618
178face morphogenesis (GO:0060325)2.32181691
179cranial nerve structural organization (GO:0021604)2.31758531
180regulation of cell communication by electrical coupling (GO:0010649)2.31720098
181regulation of endothelial cell differentiation (GO:0045601)2.30772708
182negative regulation of cAMP-mediated signaling (GO:0043951)2.30260688
183endothelial cell morphogenesis (GO:0001886)2.30212007
184actin-mediated cell contraction (GO:0070252)2.29886152
185renal filtration (GO:0097205)2.29043173
186substrate-dependent cell migration (GO:0006929)2.28904544
187facial nerve structural organization (GO:0021612)2.28645612

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.22746461
2GBX2_23144817_ChIP-Seq_PC3_Human3.43325019
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.31809782
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.01574875
5RARG_19884340_ChIP-ChIP_MEFs_Mouse2.83424615
6SMAD_19615063_ChIP-ChIP_OVARY_Human2.81358465
7TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.66620881
8CLOCK_20551151_ChIP-Seq_293T_Human2.51738879
9GATA1_22025678_ChIP-Seq_K562_Human2.45776838
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.45510297
11RXR_22158963_ChIP-Seq_LIVER_Mouse2.44552121
12EZH2_22144423_ChIP-Seq_EOC_Human2.43838694
13LXR_22158963_ChIP-Seq_LIVER_Mouse2.38232284
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.29463518
15AR_21572438_ChIP-Seq_LNCaP_Human2.10814914
16SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.10562579
17CDX2_19796622_ChIP-Seq_MESCs_Mouse2.09107972
18CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.09106894
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.05569692
20SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.03528170
21ZFP57_27257070_Chip-Seq_ESCs_Mouse1.98062735
22EZH2_18974828_ChIP-Seq_MESCs_Mouse1.98013414
23RNF2_18974828_ChIP-Seq_MESCs_Mouse1.98013414
24* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.96951112
25SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.96127323
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.94393258
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.93330900
28BP1_19119308_ChIP-ChIP_Hs578T_Human1.92742021
29PPARA_22158963_ChIP-Seq_LIVER_Mouse1.91315639
30TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.90097713
31PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.89507703
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.89462347
33EGR1_23403033_ChIP-Seq_LIVER_Mouse1.87642225
34NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.87288760
35JARID2_20064375_ChIP-Seq_MESCs_Mouse1.85769107
36STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.83342657
37EZH2_27304074_Chip-Seq_ESCs_Mouse1.82420032
38PIAS1_25552417_ChIP-Seq_VCAP_Human1.81289968
39CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.78525322
40EP300_21415370_ChIP-Seq_HL-1_Mouse1.78091935
41PCGF2_27294783_Chip-Seq_ESCs_Mouse1.73371981
42DROSHA_22980978_ChIP-Seq_HELA_Human1.73091464
43JARID2_20075857_ChIP-Seq_MESCs_Mouse1.70058545
44* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.69766104
45RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.68661304
46SUZ12_27294783_Chip-Seq_NPCs_Mouse1.68361672
47PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.67390518
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.63748765
49CJUN_26792858_Chip-Seq_BT549_Human1.63582092
50* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.59105622
51TBX20_22080862_ChIP-Seq_HEART_Mouse1.57368910
52TBX20_22328084_ChIP-Seq_HEART_Mouse1.57368910
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.56849489
54GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.52202313
55GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52074718
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.51801185
57TP53_18474530_ChIP-ChIP_U2OS_Human1.50312788
58P300_19829295_ChIP-Seq_ESCs_Human1.50288310
59EZH2_27294783_Chip-Seq_NPCs_Mouse1.49779951
60PCGF2_27294783_Chip-Seq_NPCs_Mouse1.46899327
61RNF2_27304074_Chip-Seq_ESCs_Mouse1.46049694
62NFE2_27457419_Chip-Seq_LIVER_Mouse1.45462686
63MTF2_20144788_ChIP-Seq_MESCs_Mouse1.43673178
64EZH2_27294783_Chip-Seq_ESCs_Mouse1.43031716
65SMAD4_21799915_ChIP-Seq_A2780_Human1.41274219
66TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.41142411
67* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.39904193
68ESR2_21235772_ChIP-Seq_MCF-7_Human1.37917496
69TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37188615
70FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.36660262
71EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.36042514
72PPAR_26484153_Chip-Seq_NCI-H1993_Human1.33492490
73E2F1_18555785_Chip-Seq_ESCs_Mouse1.32114903
74NANOG_18555785_Chip-Seq_ESCs_Mouse1.30734335
75RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.29695069
76ZNF217_24962896_ChIP-Seq_MCF-7_Human1.29503516
77SMAD3_21741376_ChIP-Seq_EPCs_Human1.27461921
78PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.27103184
79VDR_22108803_ChIP-Seq_LS180_Human1.27011674
80NFIB_24661679_ChIP-Seq_LUNG_Mouse1.25583396
81SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.25263412
82TP53_16413492_ChIP-PET_HCT116_Human1.24911851
83AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24709187
84BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24299943
85SUZ12_18555785_Chip-Seq_ESCs_Mouse1.23918514
86NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23812761
87STAT3_18555785_Chip-Seq_ESCs_Mouse1.22957437
88GATA2_21666600_ChIP-Seq_HMVEC_Human1.21386580
89SUZ12_27294783_Chip-Seq_ESCs_Mouse1.21163640
90AR_25329375_ChIP-Seq_VCAP_Human1.20972246
91EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.20300244
92TAF15_26573619_Chip-Seq_HEK293_Human1.19931093
93ER_23166858_ChIP-Seq_MCF-7_Human1.18243916
94P53_22387025_ChIP-Seq_ESCs_Mouse1.17695184
95THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.17577931
96* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.16870543
97SOX9_24532713_ChIP-Seq_HFSC_Mouse1.13943285
98ESR1_20079471_ChIP-ChIP_T-47D_Human1.13341810
99TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.13079329
100NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12721121
101SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12487257
102NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11929091
103NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11929091
104TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11685301
105TCF4_18268006_ChIP-ChIP_LS174T_Human1.11489202
106CMYC_18555785_Chip-Seq_ESCs_Mouse1.11309518
107NMYC_18555785_Chip-Seq_ESCs_Mouse1.11184167
108EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.11063727
109ARNT_22903824_ChIP-Seq_MCF-7_Human1.10400475
110FUS_26573619_Chip-Seq_HEK293_Human1.10359208
111BCAT_22108803_ChIP-Seq_LS180_Human1.10170090
112CRX_20693478_ChIP-Seq_RETINA_Mouse1.09535679
113AHR_22903824_ChIP-Seq_MCF-7_Human1.09081975
114RUNX2_22187159_ChIP-Seq_PCA_Human1.09027309
115* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08961820
116P300_18555785_Chip-Seq_ESCs_Mouse1.08149723
117SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08121872
118* TCF4_23295773_ChIP-Seq_U87_Human1.07440794
119BRD4_25478319_ChIP-Seq_HGPS_Human1.07135958
120POU5F1_16153702_ChIP-ChIP_HESCs_Human1.06717418
121OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06592110
122STAT3_23295773_ChIP-Seq_U87_Human1.05977339
123WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05796875
124Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.04940069
125OCT4_18555785_Chip-Seq_ESCs_Mouse1.04442639
126SALL4_18804426_ChIP-ChIP_XEN_Mouse1.04376722
127CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04262089
128OCT4_21477851_ChIP-Seq_ESCs_Mouse1.04165507
129SOX2_18555785_Chip-Seq_ESCs_Mouse1.04072855
130KDM2B_26808549_Chip-Seq_REH_Human1.03481646
131ZFX_18555785_Chip-Seq_ESCs_Mouse1.03218272
132SA1_22415368_ChIP-Seq_MEFs_Mouse1.02893535
133PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.02775537
134FOXA2_19822575_ChIP-Seq_HepG2_Human1.01099169
135TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.00396299
136CTNNB1_20460455_ChIP-Seq_HCT116_Human0.95353359
137ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95274787
138WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.92220708
139MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.90272045
140NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.89682970
141SOX2_20726797_ChIP-Seq_SW620_Human0.88245313
142ESR1_21235772_ChIP-Seq_MCF-7_Human0.87700266
143SMC1_22415368_ChIP-Seq_MEFs_Mouse0.85860894
144TP63_17297297_ChIP-ChIP_HaCaT_Human0.84328864
145SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.83553099
146CBP_21632823_ChIP-Seq_H3396_Human0.81866022
147SMC3_22415368_ChIP-Seq_MEFs_Mouse0.80443353
148RXR_22108803_ChIP-Seq_LS180_Human0.79527008
149FOXO3_23340844_ChIP-Seq_DLD1_Human0.78954610
150ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.77997018
151WT1_19549856_ChIP-ChIP_CCG9911_Human0.77992165
152EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.75532736
153CDX2_22108803_ChIP-Seq_LS180_Human0.75473219
154MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.74034226

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005503_abnormal_tendon_morphology8.17438422
2MP0008438_abnormal_cutaneous_collagen7.32387802
3MP0005275_abnormal_skin_tensile5.65948201
4MP0005666_abnormal_adipose_tissue3.34925762
5MP0002108_abnormal_muscle_morphology3.00722413
6MP0005257_abnormal_intraocular_pressure2.94687589
7MP0000751_myopathy2.74824493
8MP0005171_absent_coat_pigmentation2.74180282
9MP0002971_abnormal_brown_adipose2.69379330
10MP0004272_abnormal_basement_membrane2.68995169
11MP0005375_adipose_tissue_phenotype2.64668355
12MP0001958_emphysema2.62355148
13MP0003705_abnormal_hypodermis_morpholog2.53565107
14MP0003279_aneurysm2.49218153
15MP0001879_abnormal_lymphatic_vessel2.29211397
16MP0003724_increased_susceptibility_to2.15662796
17MP0005508_abnormal_skeleton_morphology2.15055529
18MP0010368_abnormal_lymphatic_system2.09021501
19MP0010329_abnormal_lipoprotein_level2.07936456
20MP0009115_abnormal_fat_cell1.93990097
21MP0000749_muscle_degeneration1.93965869
22MP0000003_abnormal_adipose_tissue1.78366428
23MP0003868_abnormal_feces_composition1.73162601
24MP0004185_abnormal_adipocyte_glucose1.72084611
25MP0003959_abnormal_lean_body1.72023436
26MP0003828_pulmonary_edema1.63017247
27MP0004215_abnormal_myocardial_fiber1.62125278
28MP0003950_abnormal_plasma_membrane1.55071394
29MP0005369_muscle_phenotype1.49463144
30MP0004484_altered_response_of1.49046793
31MP0002837_dystrophic_cardiac_calcinosis1.48506048
32MP0002970_abnormal_white_adipose1.46033084
33MP0003941_abnormal_skin_development1.45365380
34MP0003690_abnormal_glial_cell1.45222208
35MP0004084_abnormal_cardiac_muscle1.41162566
36MP0002060_abnormal_skin_morphology1.40856256
37MP0000013_abnormal_adipose_tissue1.39701700
38MP0009250_abnormal_appendicular_skeleto1.39174071
39MP0004145_abnormal_muscle_electrophysio1.37806430
40MP0003011_delayed_dark_adaptation1.36254330
41MP0003186_abnormal_redox_activity1.33277200
42MP0005334_abnormal_fat_pad1.30141800
43MP0002295_abnormal_pulmonary_circulatio1.28982467
44MP0005365_abnormal_bile_salt1.27728204
45MP0003385_abnormal_body_wall1.24729657
46MP0002933_joint_inflammation1.24698049
47MP0000750_abnormal_muscle_regeneration1.23190974
48MP0008775_abnormal_heart_ventricle1.22710239
49MP0003646_muscle_fatigue1.22040088
50MP0005620_abnormal_muscle_contractility1.21912298
51MP0005390_skeleton_phenotype1.20295982
52MP0005164_abnormal_response_to1.18578763
53MP0002118_abnormal_lipid_homeostasis1.17819673
54MP0003191_abnormal_cellular_cholesterol1.17407531
55MP0005165_increased_susceptibility_to1.17127194
56MP0005023_abnormal_wound_healing1.16732742
57MP0005535_abnormal_body_temperature1.16394714
58MP0005330_cardiomyopathy1.16369541
59MP0004134_abnormal_chest_morphology1.16311876
60MP0004036_abnormal_muscle_relaxation1.16262847
61MP0010386_abnormal_urinary_bladder1.15671919
62MP0005595_abnormal_vascular_smooth1.12427777
63MP0002972_abnormal_cardiac_muscle1.11622600
64MP0000343_altered_response_to1.11587012
65MP0002139_abnormal_hepatobiliary_system1.10307837
66MP0000767_abnormal_smooth_muscle1.08285897
67MP0004147_increased_porphyrin_level1.06215882
68MP0005623_abnormal_meninges_morphology1.04172704
69MP0000249_abnormal_blood_vessel1.03911810
70MP0002106_abnormal_muscle_physiology1.03394175
71MP0002249_abnormal_larynx_morphology1.02079640
72MP0003045_fibrosis1.00822539
73MP0005167_abnormal_blood-brain_barrier0.99548055
74MP0005360_urolithiasis0.99409635
75MP0006054_spinal_hemorrhage0.98170112
76MP0006292_abnormal_olfactory_placode0.98123765
77MP0003136_yellow_coat_color0.97673449
78MP0005670_abnormal_white_adipose0.96716211
79MP0004782_abnormal_surfactant_physiolog0.95766960
80MP0001986_abnormal_taste_sensitivity0.95397439
81MP0000566_synostosis0.93936531
82MP0001188_hyperpigmentation0.93478874
83MP0000534_abnormal_ureter_morphology0.92139840
84MP0002638_abnormal_pupillary_reflex0.90820876
85MP0005646_abnormal_pituitary_gland0.90272854
86MP0002896_abnormal_bone_mineralization0.90183486
87MP0002998_abnormal_bone_remodeling0.88827286
88MP0001661_extended_life_span0.88199867
89MP0005448_abnormal_energy_balance0.87551572
90MP0001544_abnormal_cardiovascular_syste0.87321829
91MP0005385_cardiovascular_system_phenoty0.87321829
92MP0005647_abnormal_sex_gland0.86878886
93MP0000163_abnormal_cartilage_morphology0.84082058
94MP0003137_abnormal_impulse_conducting0.82318150
95MP0005452_abnormal_adipose_tissue0.82256985
96MP0004883_abnormal_blood_vessel0.81208473
97MP0000049_abnormal_middle_ear0.80494842
98MP0002133_abnormal_respiratory_system0.79888170
99MP0005388_respiratory_system_phenotype0.79888170
100MP0002168_other_aberrant_phenotype0.79685020
101MP0006138_congestive_heart_failure0.79148431
102MP0008004_abnormal_stomach_pH0.78527155
103MP0002115_abnormal_skeleton_extremities0.77774719
104MP0000759_abnormal_skeletal_muscle0.77079438
105MP0009780_abnormal_chondrocyte_physiolo0.76415199
106MP0009697_abnormal_copulation0.76001404
107MP0002909_abnormal_adrenal_gland0.73988350
108MP0009379_abnormal_foot_pigmentation0.73974117
109MP0003091_abnormal_cell_migration0.73695614
110MP0001542_abnormal_bone_strength0.72842137
111MP0005084_abnormal_gallbladder_morpholo0.70483067
112MP0004133_heterotaxia0.70111182
113MP0004087_abnormal_muscle_fiber0.69941084
114MP0009764_decreased_sensitivity_to0.69906008
115MP0002102_abnormal_ear_morphology0.69237776
116MP0004085_abnormal_heartbeat0.69138055
117MP0002128_abnormal_blood_circulation0.67706296
118MP0001243_abnormal_dermal_layer0.67023021
119MP0002109_abnormal_limb_morphology0.66072460
120MP0005409_darkened_coat_color0.65827297
121MP0004130_abnormal_muscle_cell0.65769667
122MP0000747_muscle_weakness0.64321662
123MP0001614_abnormal_blood_vessel0.63945710
124MP0002938_white_spotting0.63290949
125MP0003566_abnormal_cell_adhesion0.63105581
126MP0001851_eye_inflammation0.62961879
127MP0005085_abnormal_gallbladder_physiolo0.60937934
128MP0009384_cardiac_valve_regurgitation0.60863202
129MP0002113_abnormal_skeleton_development0.60182673
130MP0002078_abnormal_glucose_homeostasis0.59687624
131MP0002932_abnormal_joint_morphology0.59556625
132MP0001501_abnormal_sleep_pattern0.59252619
133MP0001299_abnormal_eye_distance/0.56569930
134MP0002089_abnormal_postnatal_growth/wei0.56214824
135MP0005332_abnormal_amino_acid0.55939932
136MP0005584_abnormal_enzyme/coenzyme_acti0.55900521
137MP0000733_abnormal_muscle_development0.55566040
138MP0002006_tumorigenesis0.55353261
139MP0001533_abnormal_skeleton_physiology0.54547688
140MP0002876_abnormal_thyroid_physiology0.53938728
141MP0010630_abnormal_cardiac_muscle0.52962379
142MP0001270_distended_abdomen0.52841390
143MP0002116_abnormal_craniofacial_bone0.52233732
144MP0003938_abnormal_ear_development0.50516976
145MP0003935_abnormal_craniofacial_develop0.49935236
146MP0000230_abnormal_systemic_arterial0.47753064

Predicted human phenotypes

RankGene SetZ-score
1Complement deficiency (HP:0004431)6.05992002
2Broad metatarsal (HP:0001783)5.37870648
3Abnormality of complement system (HP:0005339)5.26675097
4Pulmonary artery stenosis (HP:0004415)4.83838942
5Oligomenorrhea (HP:0000876)4.61366386
6Systemic lupus erythematosus (HP:0002725)4.59330439
7Follicular hyperkeratosis (HP:0007502)4.58227094
8Protrusio acetabuli (HP:0003179)4.47251756
9Acanthosis nigricans (HP:0000956)4.01457957
10Duplicated collecting system (HP:0000081)3.92625676
11Neonatal short-limb short stature (HP:0008921)3.92494291
12Type 1 muscle fiber predominance (HP:0003803)3.67534169
13Arterial tortuosity (HP:0005116)3.65015914
14Premature rupture of membranes (HP:0001788)3.60788349
15Hyperlipoproteinemia (HP:0010980)3.58941394
16Abnormality of the renal collecting system (HP:0004742)3.54910722
17Hypertriglyceridemia (HP:0002155)3.53238931
18Increased connective tissue (HP:0009025)3.46041332
19Soft skin (HP:0000977)3.44351929
20Muscle fiber splitting (HP:0003555)3.41447503
21Glomerulonephritis (HP:0000099)3.29930534
22Ankle contracture (HP:0006466)3.29071584
23Aortic dissection (HP:0002647)3.26522424
24Atrial fibrillation (HP:0005110)3.15849647
25Wrist flexion contracture (HP:0001239)3.15089446
26Dilatation of the ascending aorta (HP:0005111)2.94571594
27Striae distensae (HP:0001065)2.93577923
28Corneal dystrophy (HP:0001131)2.90653282
29Ectopia lentis (HP:0001083)2.86356030
30Wormian bones (HP:0002645)2.86226850
31Spinal rigidity (HP:0003306)2.86042999
32Keratoconus (HP:0000563)2.85523920
33Increased corneal curvature (HP:0100692)2.85523920
34Vertebral compression fractures (HP:0002953)2.84406534
35Metaphyseal dysplasia (HP:0100255)2.79122100
36Primary atrial arrhythmia (HP:0001692)2.77535363
37Aortic valve stenosis (HP:0001650)2.75489243
38Flat cornea (HP:0007720)2.75156221
39Abnormality of monocarboxylic acid metabolism (HP:0010996)2.74055364
40Chronic hepatic failure (HP:0100626)2.73780676
41Round ear (HP:0100830)2.70710570
42Chromosomal breakage induced by crosslinking agents (HP:0003221)2.66582253
43Abnormality of molar morphology (HP:0011070)2.66517670
44Abnormality of molar (HP:0011077)2.66517670
45Calf muscle hypertrophy (HP:0008981)2.64663802
46Ventricular tachycardia (HP:0004756)2.63863809
47Mitral valve prolapse (HP:0001634)2.63789991
48Osteolytic defects of the hand bones (HP:0009699)2.63357992
49Osteolytic defects of the phalanges of the hand (HP:0009771)2.63357992
50Supraventricular arrhythmia (HP:0005115)2.62367982
51Distal lower limb muscle weakness (HP:0009053)2.61762734
52Congenital, generalized hypertrichosis (HP:0004540)2.61510982
53Nephritis (HP:0000123)2.59925785
54Myocardial infarction (HP:0001658)2.59512245
55Supraventricular tachycardia (HP:0004755)2.58265336
56Skin nodule (HP:0200036)2.58122201
57Hypoplasia of the iris (HP:0007676)2.57408983
58Lipoatrophy (HP:0100578)2.53272470
59Muscle hypertrophy of the lower extremities (HP:0008968)2.51004175
60Blue sclerae (HP:0000592)2.48263882
61Bone cyst (HP:0012062)2.47706074
62Limited hip movement (HP:0008800)2.47100036
63Back pain (HP:0003418)2.44204961
64Mitral stenosis (HP:0001718)2.43343712
65Polycythemia (HP:0001901)2.42582656
66Bladder diverticulum (HP:0000015)2.40893396
67Aneurysm (HP:0002617)2.37738292
68Prolonged QT interval (HP:0001657)2.36923908
69Hypoalphalipoproteinemia (HP:0003233)2.35969699
70Insulin resistance (HP:0000855)2.34615423
71Difficulty running (HP:0009046)2.33216747
72Joint stiffness (HP:0001387)2.31956854
73Pigmentary retinal degeneration (HP:0001146)2.30898794
74Xanthomatosis (HP:0000991)2.30384573
75Slender build (HP:0001533)2.29658876
76Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.27338234
77Shallow orbits (HP:0000586)2.26315676
78Abnormality of the calf musculature (HP:0001430)2.25459905
79Abnormality of the dental pulp (HP:0006479)2.25215712
80Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.22334817
81Venous abnormality (HP:0002624)2.20656964
82Enlarged penis (HP:0000040)2.19500406
83Hemorrhage of the eye (HP:0011885)2.18075646
84Deep venous thrombosis (HP:0002625)2.15355752
85Chromsome breakage (HP:0040012)2.14972760
86Long foot (HP:0001833)2.14043306
87Hyporeflexia of lower limbs (HP:0002600)2.13745213
88Asymmetric septal hypertrophy (HP:0001670)2.13536551
89Bell-shaped thorax (HP:0001591)2.13457119
90Increased variability in muscle fiber diameter (HP:0003557)2.12153146
91Infantile muscular hypotonia (HP:0008947)2.12013506
92Fragile skin (HP:0001030)2.11841696
93Abnormal delivery (HP:0001787)2.10842093
94Hyperextensible skin (HP:0000974)2.10766266
95Peritonitis (HP:0002586)2.10690237
96Epidermoid cyst (HP:0200040)2.09780278
97Wide anterior fontanel (HP:0000260)2.07029558
98Natal tooth (HP:0000695)2.06550466
99Sudden death (HP:0001699)2.06457333
100Joint hemorrhage (HP:0005261)2.06138206
101Thick nail (HP:0001805)2.05770527
102Advanced eruption of teeth (HP:0006288)2.03039271
103Right ventricular cardiomyopathy (HP:0011663)2.01561410
104Aortic aneurysm (HP:0004942)2.01477708
105Spondylolisthesis (HP:0003302)2.01037440
106Abnormality of permanent molar morphology (HP:0011071)2.00987089
107Abnormality of the dental root (HP:0006486)2.00987089
108Taurodontia (HP:0000679)2.00987089
109Bulbar palsy (HP:0001283)2.00475042
110Ovoid vertebral bodies (HP:0003300)1.98806996
111Short hallux (HP:0010109)1.98317917
112Insulin-resistant diabetes mellitus (HP:0000831)1.98225216
113Neck muscle weakness (HP:0000467)1.97338521
114Submucous cleft hard palate (HP:0000176)1.95769154
115Narrow nasal bridge (HP:0000446)1.95699708
116Hypoplastic ischia (HP:0003175)1.95397652
117Cervical subluxation (HP:0003308)1.95314235
118Mild short stature (HP:0003502)1.94046653
119Amyloidosis (HP:0011034)1.93872893
120Hip contracture (HP:0003273)1.93730185
121Septo-optic dysplasia (HP:0100842)1.93516668
122Abnormality of skeletal muscle fiber size (HP:0012084)1.90822045
123Steatorrhea (HP:0002570)1.88269637
124Abnormality of dentin (HP:0010299)1.87342106
125Hypercholesterolemia (HP:0003124)1.85457437
126Prominent supraorbital ridges (HP:0000336)1.84742319
127Atrophic scars (HP:0001075)1.83085934
128Lymphangioma (HP:0100764)1.82298643
129Joint laxity (HP:0001388)1.81740529
130Mildly elevated creatine phosphokinase (HP:0008180)1.79904637
131Abnormality of aromatic amino acid family metabolism (HP:0004338)1.78741895
132Coxa vara (HP:0002812)1.78461088
133Vascular tortuosity (HP:0004948)1.78439355
134Prostate neoplasm (HP:0100787)1.78029663
135Portal hypertension (HP:0001409)1.77533279
136Conical tooth (HP:0000698)1.77212052
137Broad ribs (HP:0000885)1.75609377
138Aplasia cutis congenita (HP:0001057)1.75436912
139Reduced subcutaneous adipose tissue (HP:0003758)1.74602926
140Hypolipoproteinemia (HP:0010981)1.74500402
141Fat malabsorption (HP:0002630)1.73702587
142Cerebral aneurysm (HP:0004944)1.73561544
143Chondrocalcinosis (HP:0000934)1.73486903
144Abnormal eating behavior (HP:0100738)1.73313834
145Axonal loss (HP:0003447)1.72974779
146Abnormal EKG (HP:0003115)1.72964136
147Bradycardia (HP:0001662)1.71629950
148Abnormality of the hepatic vasculature (HP:0006707)1.69773684
149Overgrowth (HP:0001548)1.69444545
150Aortic regurgitation (HP:0001659)1.65692406
151Dynein arm defect of respiratory motile cilia (HP:0012255)1.64820473
152Absent/shortened dynein arms (HP:0200106)1.64820473
153Aplasia/Hypoplasia of the tibia (HP:0005772)1.64556451
154Abnormality of the sella turcica (HP:0002679)1.63982571
155Congenital hepatic fibrosis (HP:0002612)1.63816440
156Abnormality of the ischium (HP:0003174)1.61411184
157Cardiovascular calcification (HP:0011915)1.60630549
158Muscular dystrophy (HP:0003560)1.60215299
159Biconcave vertebral bodies (HP:0004586)1.59987194
160Abnormality of the nasal septum (HP:0000419)1.59621103
161Venous insufficiency (HP:0005293)1.59418406

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR6.34007478
2TIE13.89245391
3ZAK3.68411240
4RIPK13.02299950
5OBSCN2.36627227
6ERN12.33770770
7MAP2K72.28074738
8TRPM72.21668111
9CASK2.06423311
10TNIK2.01979879
11PINK11.95546637
12TGFBR21.91462431
13ABL21.74268685
14MUSK1.71565137
15EPHA31.71430183
16PKN11.71116523
17MYLK1.66943755
18MAPKAPK31.66552242
19TRIB31.62631538
20LATS21.60778131
21IRAK31.59021118
22GRK51.56776944
23EIF2AK21.55334396
24NUAK11.55027572
25TTN1.48806000
26GRK11.41279466
27PDGFRA1.39134698
28MAPK41.38018556
29TESK11.37809361
30PAK21.32149397
31IRAK41.31446368
32ERBB31.31072825
33PHKG21.28698163
34PHKG11.28698163
35EPHB21.23778102
36TNK21.22370797
37NEK61.21951127
38TEC1.20812874
39MOS1.20642269
40CAMK1G1.16435855
41NLK1.16262566
42PRKCE1.13240224
43DMPK1.11086174
44TXK1.10770875
45LATS11.09072289
46PRPF4B1.09025505
47EEF2K1.07102334
48GRK71.05011181
49TYK21.03465303
50IRAK11.03009424
51TGFBR11.02475801
52CAMK1D0.99022001
53BMPR20.95978729
54MKNK20.93476176
55JAK10.92492661
56PDK20.90930935
57MAP3K140.90647312
58PIK3CA0.90589804
59DDR20.90260317
60PTK20.90101367
61CAMK10.88826335
62STK30.88435401
63FRK0.88019888
64GSK3A0.87975211
65MET0.86631636
66SGK20.86430973
67ADRBK20.85279447
68MAP2K10.84663783
69MAPK130.83819606
70JAK30.82750931
71SIK30.78608439
72NEK90.78411783
73MAPK150.77771435
74BMPR1B0.76967558
75MAP3K70.74001284
76YES10.73835378
77PRKAA10.73659188
78PRKACG0.73374439
79PRKD10.72282241
80CDK80.72196309
81PRKCH0.72171853
82ROCK10.72093432
83STK38L0.71929651
84AKT30.71394854
85FER0.70663489
86CSK0.69908279
87MAPK70.69729638
88PTK2B0.69013062
89CDK60.68950466
90FGFR30.67246523
91PLK20.66055021
92MAP3K30.64509962
93PRKAA20.63876613
94ILK0.63732876
95SIK10.63721367
96LMTK20.63395655
97RET0.63235411
98NTRK10.62550675
99MAP3K130.61983689
100MAPK120.61424830
101PDGFRB0.60812338
102ARAF0.60017505
103CDK30.58079122
104PRKD20.57681566
105PIK3CG0.57585573
106ADRBK10.56331837
107SGK4940.56148743
108SGK2230.56148743
109EPHB10.56136335
110JAK20.55493960
111IKBKB0.55141999
112CDC42BPA0.54492619
113KIT0.54331118
114CAMK2D0.53120540
115PRKG10.52868421
116ABL10.52487794
117IGF1R0.52483082
118BRD40.51624950
119MAPK30.51398106
120MTOR0.50460339
121CAMK40.50348593
122DAPK30.50001858
123PDPK10.49936162
124MAPKAPK50.48829362
125PRKACB0.48811152
126MKNK10.47964248
127STK380.45937939
128DYRK20.44450491
129KDR0.44056134
130CAMK2G0.44051792
131IRAK20.41987562
132CAMK2A0.41355746
133SGK30.38509353
134STK240.38028156
135VRK10.37967357
136INSR0.37446825
137PRKACA0.37293317
138MAP3K60.36675494
139MAPK10.36260061
140WNK10.36228600
141RPS6KA30.34419496
142BCR0.34045038
143FGFR20.32640715
144FGFR40.31523315
145IKBKE0.30395286
146SRC0.30101269
147MARK20.29372568
148ROCK20.29326435

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.66987574
2PPAR signaling pathway_Homo sapiens_hsa033203.53697047
3Phenylalanine metabolism_Homo sapiens_hsa003603.16553892
4Complement and coagulation cascades_Homo sapiens_hsa046102.96313729
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.74603495
6Fatty acid degradation_Homo sapiens_hsa000712.66974329
7Histidine metabolism_Homo sapiens_hsa003402.66070392
8Dilated cardiomyopathy_Homo sapiens_hsa054142.61464235
9Malaria_Homo sapiens_hsa051442.53012628
10Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.50211007
11Tyrosine metabolism_Homo sapiens_hsa003502.39444646
12Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.31338509
13Protein digestion and absorption_Homo sapiens_hsa049742.28012917
14Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.27533506
15Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.20717141
16Primary bile acid biosynthesis_Homo sapiens_hsa001202.15567068
17Retinol metabolism_Homo sapiens_hsa008302.01333228
18Arachidonic acid metabolism_Homo sapiens_hsa005902.00489065
19Tryptophan metabolism_Homo sapiens_hsa003801.97890921
20Focal adhesion_Homo sapiens_hsa045101.94285101
21Glycerolipid metabolism_Homo sapiens_hsa005611.89236434
22Cyanoamino acid metabolism_Homo sapiens_hsa004601.87768452
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.77427893
24Chemical carcinogenesis_Homo sapiens_hsa052041.74870873
25Ovarian steroidogenesis_Homo sapiens_hsa049131.74394646
26Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.67140745
27Pyruvate metabolism_Homo sapiens_hsa006201.62253352
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.61501112
29Propanoate metabolism_Homo sapiens_hsa006401.60407110
30AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.51139948
31Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.49889383
32Adipocytokine signaling pathway_Homo sapiens_hsa049201.42669031
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.42631134
34Staphylococcus aureus infection_Homo sapiens_hsa051501.40529947
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.39357223
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.38222534
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.37122445
38Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.36278693
39Pentose and glucuronate interconversions_Homo sapiens_hsa000401.35754239
40Fat digestion and absorption_Homo sapiens_hsa049751.30226793
41PI3K-Akt signaling pathway_Homo sapiens_hsa041511.29179204
42Autoimmune thyroid disease_Homo sapiens_hsa053201.29012474
43Amoebiasis_Homo sapiens_hsa051461.28278257
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.27526630
45Vitamin digestion and absorption_Homo sapiens_hsa049771.25255099
46Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.24158490
47AMPK signaling pathway_Homo sapiens_hsa041521.24009853
48Viral myocarditis_Homo sapiens_hsa054161.22438811
49Fatty acid metabolism_Homo sapiens_hsa012121.20968283
50Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.20505310
51Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.19513648
52Caffeine metabolism_Homo sapiens_hsa002321.18938307
53Ether lipid metabolism_Homo sapiens_hsa005651.17361632
54alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.17233295
55NF-kappa B signaling pathway_Homo sapiens_hsa040641.16932033
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.11800748
57TGF-beta signaling pathway_Homo sapiens_hsa043501.10460535
58Morphine addiction_Homo sapiens_hsa050321.09170520
59Fatty acid biosynthesis_Homo sapiens_hsa000611.08789622
60Linoleic acid metabolism_Homo sapiens_hsa005911.08618008
61Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.07957225
62Taste transduction_Homo sapiens_hsa047421.07951242
63Bile secretion_Homo sapiens_hsa049761.07641984
64African trypanosomiasis_Homo sapiens_hsa051431.05917383
65Arginine biosynthesis_Homo sapiens_hsa002201.05687042
66Vascular smooth muscle contraction_Homo sapiens_hsa042701.05654900
67Calcium signaling pathway_Homo sapiens_hsa040201.04646703
68Butanoate metabolism_Homo sapiens_hsa006501.04081944
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.03732086
70Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.03344378
71Other glycan degradation_Homo sapiens_hsa005111.02285184
72Small cell lung cancer_Homo sapiens_hsa052221.01080216
73Cardiac muscle contraction_Homo sapiens_hsa042601.00470528
74Adherens junction_Homo sapiens_hsa045200.98946006
75TNF signaling pathway_Homo sapiens_hsa046680.96823617
76Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.96701572
77Intestinal immune network for IgA production_Homo sapiens_hsa046720.94825242
78cAMP signaling pathway_Homo sapiens_hsa040240.94071942
79Renin-angiotensin system_Homo sapiens_hsa046140.92407555
80Rheumatoid arthritis_Homo sapiens_hsa053230.92210176
81Hematopoietic cell lineage_Homo sapiens_hsa046400.90702850
82Graft-versus-host disease_Homo sapiens_hsa053320.89871356
83Basal cell carcinoma_Homo sapiens_hsa052170.87400720
84cGMP-PKG signaling pathway_Homo sapiens_hsa040220.86534463
85Allograft rejection_Homo sapiens_hsa053300.84418886
86Sphingolipid metabolism_Homo sapiens_hsa006000.84019709
87Renin secretion_Homo sapiens_hsa049240.81748395
88Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.81425211
89Toxoplasmosis_Homo sapiens_hsa051450.79676011
90Ras signaling pathway_Homo sapiens_hsa040140.79386611
91Pathways in cancer_Homo sapiens_hsa052000.78653364
92Lysine degradation_Homo sapiens_hsa003100.77896373
93Jak-STAT signaling pathway_Homo sapiens_hsa046300.77446389
94Peroxisome_Homo sapiens_hsa041460.76835911
95Nicotine addiction_Homo sapiens_hsa050330.75462691
96Type II diabetes mellitus_Homo sapiens_hsa049300.75022227
972-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.74365000
98Notch signaling pathway_Homo sapiens_hsa043300.73665027
99Circadian entrainment_Homo sapiens_hsa047130.73397626
100SNARE interactions in vesicular transport_Homo sapiens_hsa041300.72088678
101Drug metabolism - other enzymes_Homo sapiens_hsa009830.71518248
102Toll-like receptor signaling pathway_Homo sapiens_hsa046200.71302321
103ABC transporters_Homo sapiens_hsa020100.70952740
104Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70948668
105Measles_Homo sapiens_hsa051620.70383525
106RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.69091742
107Arginine and proline metabolism_Homo sapiens_hsa003300.69051744
108Proteoglycans in cancer_Homo sapiens_hsa052050.67818426
109Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.65955146
110Fatty acid elongation_Homo sapiens_hsa000620.65880490
111Fanconi anemia pathway_Homo sapiens_hsa034600.65457107
112Melanoma_Homo sapiens_hsa052180.64663854
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62764550
114Circadian rhythm_Homo sapiens_hsa047100.62427589
115Axon guidance_Homo sapiens_hsa043600.61396388
116NOD-like receptor signaling pathway_Homo sapiens_hsa046210.60291423
117Rap1 signaling pathway_Homo sapiens_hsa040150.59403613
118Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59232373
119Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58683199
120Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58606221
121Asthma_Homo sapiens_hsa053100.58544785
122Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57548836
123Hedgehog signaling pathway_Homo sapiens_hsa043400.57337840
124Prostate cancer_Homo sapiens_hsa052150.57092853
125Glutathione metabolism_Homo sapiens_hsa004800.56712258
126Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56280637
127Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.55551004
128Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55048998
129Glycosaminoglycan degradation_Homo sapiens_hsa005310.53084501
130Platelet activation_Homo sapiens_hsa046110.52674579
131Starch and sucrose metabolism_Homo sapiens_hsa005000.52429371
132Prion diseases_Homo sapiens_hsa050200.52152396
133Serotonergic synapse_Homo sapiens_hsa047260.51978535
134Insulin signaling pathway_Homo sapiens_hsa049100.51547849
135Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51249695
136Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.51170190
137Osteoclast differentiation_Homo sapiens_hsa043800.50949611
138Insulin resistance_Homo sapiens_hsa049310.50546081
139Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49952417
140Dorso-ventral axis formation_Homo sapiens_hsa043200.49796671
141beta-Alanine metabolism_Homo sapiens_hsa004100.49645460
142MicroRNAs in cancer_Homo sapiens_hsa052060.49164733
143Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49030382
144Phospholipase D signaling pathway_Homo sapiens_hsa040720.46369230
145Pertussis_Homo sapiens_hsa051330.46353746
146Insulin secretion_Homo sapiens_hsa049110.45273658
147Mineral absorption_Homo sapiens_hsa049780.45017310
148Glycerophospholipid metabolism_Homo sapiens_hsa005640.41702322
149Glucagon signaling pathway_Homo sapiens_hsa049220.40783641
150Carbon metabolism_Homo sapiens_hsa012000.40526592
151Folate biosynthesis_Homo sapiens_hsa007900.38859114
152Sulfur metabolism_Homo sapiens_hsa009200.35334337
153Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.32451849
154Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.30238024
155Sulfur relay system_Homo sapiens_hsa041220.29516883
156Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.22784165
157Vitamin B6 metabolism_Homo sapiens_hsa007500.22569779
158Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.19875299
159Gap junction_Homo sapiens_hsa045400.17316452

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