ECSCR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is primarily found in endothelial cells and blood vessels, where it is involved in cell shape changes and EGF-induced cell migration. It can enhance the activation of vascular endothelial growth factor receptor-2/kinase insert domain receptor and also promote the proteolysis of internalized kinase insert domain receptor. This gene may play a role in angiogenesis-related diseases. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lymph vessel development (GO:0001945)8.64948453
2endothelium development (GO:0003158)8.12768128
3positive regulation of vasculogenesis (GO:2001214)7.26457256
4blood vessel maturation (GO:0001955)5.99647896
5endothelial tube morphogenesis (GO:0061154)5.94121198
6morphogenesis of an endothelium (GO:0003159)5.94121198
7lymphangiogenesis (GO:0001946)5.86055588
8regulation of endothelial cell differentiation (GO:0045601)5.82862295
9regulation of vasculogenesis (GO:2001212)5.76736034
10transcytosis (GO:0045056)5.68430200
11vascular endothelial growth factor signaling pathway (GO:0038084)5.51379592
12retina vasculature morphogenesis in camera-type eye (GO:0061299)5.49010784
13positive regulation of urine volume (GO:0035810)5.05273066
14negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)4.92155360
15cellular response to vascular endothelial growth factor stimulus (GO:0035924)4.91714105
16positive regulation of endothelial cell differentiation (GO:0045603)4.67249572
17basement membrane organization (GO:0071711)4.49926530
18endothelial cell differentiation (GO:0045446)4.48902073
19wound healing, spreading of cells (GO:0044319)4.45215069
20angiogenesis involved in wound healing (GO:0060055)4.44242432
21negative regulation of adherens junction organization (GO:1903392)4.44218608
22negative regulation of focal adhesion assembly (GO:0051895)4.44218608
23negative regulation of cell junction assembly (GO:1901889)4.44218608
24sprouting angiogenesis (GO:0002040)4.33252799
25chondrocyte proliferation (GO:0035988)4.33092334
26endothelial cell morphogenesis (GO:0001886)4.27517617
27definitive hemopoiesis (GO:0060216)4.23173295
28adhesion of symbiont to host (GO:0044406)4.21521089
29surfactant homeostasis (GO:0043129)4.07861211
30ovulation from ovarian follicle (GO:0001542)4.04016405
31vasculogenesis (GO:0001570)3.96685231
32embryonic heart tube development (GO:0035050)3.92751310
33regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.92116036
34establishment of endothelial barrier (GO:0061028)3.86142708
35negative regulation of blood vessel endothelial cell migration (GO:0043537)3.80890040
36substrate-dependent cell migration (GO:0006929)3.73233050
37vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.69860645
38negative regulation of DNA biosynthetic process (GO:2000279)3.69225939
39positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-3.68658368
40glomerular filtration (GO:0003094)3.65011186
41positive regulation of receptor recycling (GO:0001921)3.64691984
42regulation of urine volume (GO:0035809)3.61954050
43endothelial cell proliferation (GO:0001935)3.59812892
44negative regulation of endothelial cell apoptotic process (GO:2000352)3.59227990
45blood vessel endothelial cell migration (GO:0043534)3.57050068
46adhesion of symbiont to host cell (GO:0044650)3.56852322
47virion attachment to host cell (GO:0019062)3.56852322
48patterning of blood vessels (GO:0001569)3.56127677
49negative regulation of endothelial cell migration (GO:0010596)3.56076129
50positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)3.55017743
51heart trabecula formation (GO:0060347)3.53784933
52positive regulation of interleukin-8 secretion (GO:2000484)3.52453531
53renal filtration (GO:0097205)3.52301458
54hyaluronan catabolic process (GO:0030214)3.51994135
55regulation of establishment or maintenance of cell polarity (GO:0032878)3.46295196
56negative regulation of platelet activation (GO:0010544)3.44429170
57regulation of chemokine-mediated signaling pathway (GO:0070099)3.40892804
58regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)3.37443041
59histamine secretion (GO:0001821)3.36527021
60cAMP biosynthetic process (GO:0006171)3.35791709
61regulation of blood vessel endothelial cell migration (GO:0043535)3.33089114
62negative regulation of endothelial cell proliferation (GO:0001937)3.32283187
63regulation of endothelial cell migration (GO:0010594)3.27671167
64cell adhesion mediated by integrin (GO:0033627)3.27623858
65venous blood vessel morphogenesis (GO:0048845)3.26774574
66mRNA transcription from RNA polymerase II promoter (GO:0042789)3.23552654
67anatomical structure maturation (GO:0071695)3.23390615
68protein localization to cell surface (GO:0034394)3.21295022
69artery smooth muscle contraction (GO:0014824)3.20372348
70positive regulation of lipoprotein lipase activity (GO:0051006)3.20364325
71positive regulation of triglyceride lipase activity (GO:0061365)3.20364325
72mesodermal cell differentiation (GO:0048333)3.20102795
73leukocyte tethering or rolling (GO:0050901)3.17439999
74plasma membrane fusion (GO:0045026)3.16824813
75megakaryocyte development (GO:0035855)3.16747992
76ganglion development (GO:0061548)3.14185768
77heart valve formation (GO:0003188)3.13909031
78nephron epithelium development (GO:0072009)3.12969912
79positive regulation of endothelial cell migration (GO:0010595)3.12131719
80regulation of endothelial cell apoptotic process (GO:2000351)3.08804278
81positive regulation of keratinocyte differentiation (GO:0045618)3.07264512
82negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.06200291
83substrate adhesion-dependent cell spreading (GO:0034446)3.05585584
84neuron projection extension involved in neuron projection guidance (GO:1902284)3.05005507
85axon extension involved in axon guidance (GO:0048846)3.05005507
86multicellular organismal aging (GO:0010259)3.04289445
87positive regulation of odontogenesis (GO:0042482)3.02988815
88regulation of systemic arterial blood pressure by hormone (GO:0001990)3.02706148
89regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.02706148
90endocrine process (GO:0050886)3.02706148
91cell migration involved in sprouting angiogenesis (GO:0002042)3.02340657
92trabecula morphogenesis (GO:0061383)2.96978913
93negative regulation of nitric-oxide synthase activity (GO:0051001)2.96926158
94negative regulation of nitric oxide biosynthetic process (GO:0045019)2.95855528
95chemical homeostasis within a tissue (GO:0048875)2.95636765
96Notch signaling involved in heart development (GO:0061314)2.93942036
97SMAD protein complex assembly (GO:0007183)2.93322424
98mRNA transcription (GO:0009299)2.92877642
99ventricular trabecula myocardium morphogenesis (GO:0003222)2.92576012
100regulation of focal adhesion assembly (GO:0051893)2.92329302
101regulation of cell-substrate junction assembly (GO:0090109)2.92329302
102tonic smooth muscle contraction (GO:0014820)2.91894865
103regulation of sarcomere organization (GO:0060297)2.89512184
104heart trabecula morphogenesis (GO:0061384)2.89393618
105negative regulation of vascular permeability (GO:0043116)2.88429376
106endothelial cell migration (GO:0043542)2.87315304
107regulation of glomerular filtration (GO:0003093)2.87215074
108* angiogenesis (GO:0001525)2.85029701
109negative regulation of epithelial cell migration (GO:0010633)2.82583458
110positive regulation of endothelial cell proliferation (GO:0001938)2.81596045
111regulation of endothelial cell proliferation (GO:0001936)2.80139288
112peptidyl-tyrosine autophosphorylation (GO:0038083)2.79987083
113positive regulation of smooth muscle cell migration (GO:0014911)2.77754215
114negative regulation of angiogenesis (GO:0016525)2.77528762
115protein kinase C signaling (GO:0070528)2.76338084
116positive regulation of focal adhesion assembly (GO:0051894)2.75896527
117positive regulation of cell junction assembly (GO:1901890)2.75896527
118artery development (GO:0060840)2.71279777
119pathway-restricted SMAD protein phosphorylation (GO:0060389)2.71150539
120negative regulation of blood vessel morphogenesis (GO:2000181)2.69046868
121regulation of epithelial cell migration (GO:0010632)2.64651932
122cell migration involved in heart development (GO:0060973)2.64584447
123endoderm formation (GO:0001706)2.64394440
124renal system development (GO:0072001)2.63164412
125phagocytosis, recognition (GO:0006910)2.61876747
126response to laminar fluid shear stress (GO:0034616)2.61446943
127negative regulation of cell fate specification (GO:0009996)2.59489158
128regulation of lipoprotein particle clearance (GO:0010984)2.59263695
129embryonic foregut morphogenesis (GO:0048617)2.59035039
130wound healing, spreading of epidermal cells (GO:0035313)2.58796930
131negative regulation of vasculature development (GO:1901343)2.57789061
132blood vessel remodeling (GO:0001974)2.56545915
133positive regulation of epithelial cell migration (GO:0010634)2.56256623

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.85956853
2GATA2_21666600_ChIP-Seq_HMVEC_Human4.79014472
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.64199717
4TRIM28_21343339_ChIP-Seq_HEK293_Human4.37929138
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.53088741
6RARG_19884340_ChIP-ChIP_MEFs_Mouse3.17155357
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.81570854
8CLOCK_20551151_ChIP-Seq_293T_Human2.77710512
9STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.77210893
10SMAD_19615063_ChIP-ChIP_OVARY_Human2.63611503
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.63145481
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.49135087
13ELK3_25401928_ChIP-Seq_HUVEC_Human2.47350778
14ESR1_21235772_ChIP-Seq_MCF-7_Human2.40853904
15NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.26874610
16WT1_19549856_ChIP-ChIP_CCG9911_Human2.20016761
17SCL_19346495_ChIP-Seq_HPC-7_Human2.17126187
18SALL4_18804426_ChIP-ChIP_XEN_Mouse2.15612108
19EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.12058114
20TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.05763130
21HIF1A_21447827_ChIP-Seq_MCF-7_Human2.04876891
22SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.02279237
23SOX2_20726797_ChIP-Seq_SW620_Human2.01625251
24PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.01448832
25STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.99805105
26TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.99613720
27EP300_21415370_ChIP-Seq_HL-1_Mouse1.96742440
28CJUN_26792858_Chip-Seq_BT549_Human1.93439912
29ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.87783439
30CDX2_20551321_ChIP-Seq_CACO-2_Human1.86827339
31ESR2_21235772_ChIP-Seq_MCF-7_Human1.84216342
32RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.83016796
33CDX2_19796622_ChIP-Seq_MESCs_Mouse1.71723254
34KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.71437360
35KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.71437360
36KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.71437360
37STAT6_21828071_ChIP-Seq_BEAS2B_Human1.66115961
38SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.65755992
39SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.65755992
40FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.61703395
41IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.61250003
42CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.58218769
43STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.55856624
44TBX20_22080862_ChIP-Seq_HEART_Mouse1.51851086
45TBX20_22328084_ChIP-Seq_HEART_Mouse1.51851086
46KDM2B_26808549_Chip-Seq_SUP-B15_Human1.51627970
47PPAR_26484153_Chip-Seq_NCI-H1993_Human1.50846915
48SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.50333242
49IRF8_22096565_ChIP-ChIP_GC-B_Human1.49733003
50THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.49346671
51GATA1_19941826_ChIP-Seq_K562_Human1.48536163
52GATA1_22025678_ChIP-Seq_K562_Human1.47545936
53RUNX_20019798_ChIP-Seq_JUKART_Human1.40791280
54EZH2_18974828_ChIP-Seq_MESCs_Mouse1.40243129
55RNF2_18974828_ChIP-Seq_MESCs_Mouse1.40243129
56NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.40104871
57ZNF217_24962896_ChIP-Seq_MCF-7_Human1.38864020
58BRD4_25478319_ChIP-Seq_HGPS_Human1.31319825
59ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.31209484
60JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.28290479
61PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.28002133
62RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.27568744
63EGR1_19374776_ChIP-ChIP_THP-1_Human1.27098950
64JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.25915867
65MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.24978196
66SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.24741111
67CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.21974622
68SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.20904069
69FOXO3_23340844_ChIP-Seq_DLD1_Human1.19473206
70TCF4_18268006_ChIP-ChIP_LS174T_Human1.17183908
71PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.14011974
72SMC3_22415368_ChIP-Seq_MEFs_Mouse1.13334822
73SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.12850234
74SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.11307809
75ESR1_20079471_ChIP-ChIP_T-47D_Human1.11094735
76VDR_24787735_ChIP-Seq_THP-1_Human1.10844537
77LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.10184826
78SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.08139192
79TCF3_18692474_ChIP-Seq_MEFs_Mouse1.07411699
80KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.07362478
81MYB_21317192_ChIP-Seq_ERMYB_Mouse1.04943651
82PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04510339
83SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.04219854
84MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.03592585
85SPI1_23127762_ChIP-Seq_K562_Human1.03183784
86SOX9_24532713_ChIP-Seq_HFSC_Mouse1.02890450
87NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.00521738
88NRF2_20460467_ChIP-Seq_MEFs_Mouse1.00521738
89SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.00462895
90STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.00244443
91ZFP57_27257070_Chip-Seq_ESCs_Mouse0.99906194
92NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99587204
93IRF8_27001747_Chip-Seq_BMDM_Mouse0.98943451
94NR3C1_23031785_ChIP-Seq_PC12_Mouse0.98782473
95PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.98270384
96RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.97437605
97CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.97171890
98GATA2_19941826_ChIP-Seq_K562_Human0.95520926
99ZNF263_19887448_ChIP-Seq_K562_Human0.95324513
100MTF2_20144788_ChIP-Seq_MESCs_Mouse0.94927397
101PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.94283040
102MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.92849748
103CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.92802188
104SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92336652
105KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.91077722
106SMC1_22415368_ChIP-Seq_MEFs_Mouse0.90689429
107CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.87889990
108FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.87816350
109ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.86985618
110SOX17_20123909_ChIP-Seq_XEN_Mouse0.86874194
111UBF1/2_26484160_Chip-Seq_HMECs_Human0.86408765
112BCAT_22108803_ChIP-Seq_LS180_Human0.86288607
113PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.86157441
114TCF7_22412390_ChIP-Seq_EML_Mouse0.85237129
115Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.85047087
116BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.84893098
117SA1_22415368_ChIP-Seq_MEFs_Mouse0.84686265
118LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.84385140
119HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.83666311
120EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.83382625
121VDR_22108803_ChIP-Seq_LS180_Human0.83250156
122WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.82353905
123OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.82162255
124NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.80965880
125SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.80105419
126TP63_23658742_ChIP-Seq_EP156T_Human0.79883126
127NANOG_18692474_ChIP-Seq_MEFs_Mouse0.79631199
128P63_26484246_Chip-Seq_KERATINOCYTES_Human0.79176195
129SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.78874074
130EED_16625203_ChIP-ChIP_MESCs_Mouse0.78252151
131P300_19829295_ChIP-Seq_ESCs_Human0.77531228
132TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.76718349
133NFI_21473784_ChIP-Seq_ESCs_Mouse0.75721534
134WT1_25993318_ChIP-Seq_PODOCYTE_Human0.75449544
135LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.74312449

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system6.17438331
2MP0001879_abnormal_lymphatic_vessel6.04552733
3MP0005167_abnormal_blood-brain_barrier5.04804629
4MP0006054_spinal_hemorrhage4.50985122
5MP0004272_abnormal_basement_membrane3.93305885
6MP0003724_increased_susceptibility_to3.88303373
7MP0003279_aneurysm2.78192429
8MP0003828_pulmonary_edema2.71960711
9MP0000767_abnormal_smooth_muscle2.58434403
10MP0009379_abnormal_foot_pigmentation2.18413678
11MP0004147_increased_porphyrin_level2.08645817
12MP0010030_abnormal_orbit_morphology2.08331813
13MP0002138_abnormal_hepatobiliary_system2.05738148
14MP0005084_abnormal_gallbladder_morpholo1.94229509
15MP0005623_abnormal_meninges_morphology1.90827889
16MP0005503_abnormal_tendon_morphology1.89029997
17MP0000249_abnormal_blood_vessel1.86298128
18MP0004084_abnormal_cardiac_muscle1.85707133
19MP0003191_abnormal_cellular_cholesterol1.74409313
20MP0000465_gastrointestinal_hemorrhage1.72526648
21MP0008438_abnormal_cutaneous_collagen1.70838836
22MP0009278_abnormal_bone_marrow1.69571603
23MP0006138_congestive_heart_failure1.69181819
24MP0004883_abnormal_blood_vessel1.62223789
25MP0005595_abnormal_vascular_smooth1.55957516
26MP0002127_abnormal_cardiovascular_syste1.55866390
27MP0000343_altered_response_to1.54796035
28MP0009697_abnormal_copulation1.54135484
29MP0005171_absent_coat_pigmentation1.51511560
30MP0003567_abnormal_fetal_cardiomyocyte1.48144143
31MP0002933_joint_inflammation1.47654773
32MP0003943_abnormal_hepatobiliary_system1.45164641
33MP0002128_abnormal_blood_circulation1.40378342
34MP0002925_abnormal_cardiovascular_devel1.37659518
35MP0001915_intracranial_hemorrhage1.36536235
36MP0003950_abnormal_plasma_membrane1.36084784
37MP0001851_eye_inflammation1.36069741
38MP0002332_abnormal_exercise_endurance1.36051657
39MP0003705_abnormal_hypodermis_morpholog1.33478205
40MP0001958_emphysema1.32848190
41MP0003566_abnormal_cell_adhesion1.31548180
42MP0004233_abnormal_muscle_weight1.31102574
43MP0004145_abnormal_muscle_electrophysio1.30462073
44MP0004484_altered_response_of1.30274447
45MP0001544_abnormal_cardiovascular_syste1.29036327
46MP0005385_cardiovascular_system_phenoty1.29036327
47MP0001614_abnormal_blood_vessel1.28574981
48MP0002295_abnormal_pulmonary_circulatio1.28451715
49MP0005165_increased_susceptibility_to1.21926013
50MP0005409_darkened_coat_color1.21421922
51MP0008775_abnormal_heart_ventricle1.21252086
52MP0005164_abnormal_response_to1.14125998
53MP0010630_abnormal_cardiac_muscle1.12601959
54MP0003300_gastrointestinal_ulcer1.12459491
55MP0005023_abnormal_wound_healing1.08880915
56MP0002972_abnormal_cardiac_muscle1.07870739
57MP0003091_abnormal_cell_migration1.07820697
58MP0003045_fibrosis1.07703044
59MP0000013_abnormal_adipose_tissue1.07579370
60MP0005397_hematopoietic_system_phenotyp1.04293366
61MP0001545_abnormal_hematopoietic_system1.04293366
62MP0004808_abnormal_hematopoietic_stem1.03220302
63MP0004036_abnormal_muscle_relaxation1.00331324
64MP0003385_abnormal_body_wall0.97842625
65MP0005670_abnormal_white_adipose0.94714695
66MP0008004_abnormal_stomach_pH0.94535831
67MP0000516_abnormal_urinary_system0.93901792
68MP0005367_renal/urinary_system_phenotyp0.93901792
69MP0010234_abnormal_vibrissa_follicle0.93424998
70MP0004782_abnormal_surfactant_physiolog0.93335388
71MP0001784_abnormal_fluid_regulation0.90942766
72MP0005330_cardiomyopathy0.90427028
73MP0002877_abnormal_melanocyte_morpholog0.88118266
74MP0000266_abnormal_heart_morphology0.87817533
75MP0004215_abnormal_myocardial_fiber0.86413815
76MP0001542_abnormal_bone_strength0.85134651
77MP0002254_reproductive_system_inflammat0.84566738
78MP0005464_abnormal_platelet_physiology0.84063955
79MP0001849_ear_inflammation0.83399600
80MP0005275_abnormal_skin_tensile0.82304310
81MP0000049_abnormal_middle_ear0.82051661
82MP0002396_abnormal_hematopoietic_system0.82048230
83MP0001188_hyperpigmentation0.81217793
84MP0009785_altered_susceptibility_to0.79066304
85MP0003941_abnormal_skin_development0.78187106
86MP0010155_abnormal_intestine_physiology0.77977903
87MP0001533_abnormal_skeleton_physiology0.76608761
88MP0000749_muscle_degeneration0.76460865
89MP0000751_myopathy0.76089345
90MP0005620_abnormal_muscle_contractility0.75587245
91MP0000230_abnormal_systemic_arterial0.74308911
92MP0005508_abnormal_skeleton_morphology0.73914299
93MP0004085_abnormal_heartbeat0.73243449
94MP0002086_abnormal_extraembryonic_tissu0.73091590
95MP0003868_abnormal_feces_composition0.70459779
96MP0003935_abnormal_craniofacial_develop0.68982556
97MP0003122_maternal_imprinting0.68490146
98MP0004510_myositis0.67016383
99MP0000733_abnormal_muscle_development0.66168486
100MP0002168_other_aberrant_phenotype0.65414377
101MP0003984_embryonic_growth_retardation0.64110673
102MP0005388_respiratory_system_phenotype0.64107656
103MP0002133_abnormal_respiratory_system0.64107656
104MP0002088_abnormal_embryonic_growth/wei0.63600350
105MP0003303_peritoneal_inflammation0.62729899
106MP0003638_abnormal_response/metabolism_0.62296185
107MP0000613_abnormal_salivary_gland0.62002107
108MP0003448_altered_tumor_morphology0.61462441
109MP0005380_embryogenesis_phenotype0.59111621
110MP0001672_abnormal_embryogenesis/_devel0.59111621
111MP0002932_abnormal_joint_morphology0.58590585
112MP0001270_distended_abdomen0.58537727
113MP0001175_abnormal_lung_morphology0.57984790
114MP0004087_abnormal_muscle_fiber0.57356048
115MP0001853_heart_inflammation0.57052417
116MP0002108_abnormal_muscle_morphology0.56594362
117MP0002796_impaired_skin_barrier0.55564506
118MP0005197_abnormal_uvea_morphology0.55240002
119MP0010352_gastrointestinal_tract_polyps0.52132462
120MP0005187_abnormal_penis_morphology0.50207981
121MP0000467_abnormal_esophagus_morphology0.49748231
122MP0002106_abnormal_muscle_physiology0.49212898
123MP0009764_decreased_sensitivity_to0.46636379
124MP0001293_anophthalmia0.46513281
125MP0003186_abnormal_redox_activity0.46284610
126MP0009780_abnormal_chondrocyte_physiolo0.46272126
127MP0002896_abnormal_bone_mineralization0.45532859
128MP0005369_muscle_phenotype0.44757957
129MP0005166_decreased_susceptibility_to0.44595457

Predicted human phenotypes

RankGene SetZ-score
1Hematochezia (HP:0002573)6.57201527
2Spontaneous hematomas (HP:0007420)6.08808344
3Polycythemia (HP:0001901)5.23099461
4Nonimmune hydrops fetalis (HP:0001790)4.85672650
5Aortic aneurysm (HP:0004942)4.74973038
6Wrist flexion contracture (HP:0001239)4.54783939
7Cerebral aneurysm (HP:0004944)4.50912977
8Vascular tortuosity (HP:0004948)4.45558555
9Tetraparesis (HP:0002273)4.13592269
10Esophageal varix (HP:0002040)4.09767868
11Arterial tortuosity (HP:0005116)3.97663394
12Abnormality of the nasal mucosa (HP:0000433)3.82578433
13Colitis (HP:0002583)3.64509150
14Congenital, generalized hypertrichosis (HP:0004540)3.37640374
15Aortic dissection (HP:0002647)3.32747754
16Asymmetry of the thorax (HP:0001555)3.28786339
17Conjunctival telangiectasia (HP:0000524)3.28439655
18Facial diplegia (HP:0001349)3.27640488
19Broad metatarsal (HP:0001783)3.24559010
20Lymphangioma (HP:0100764)3.21633572
21Myotonia (HP:0002486)3.18681031
22Portal hypertension (HP:0001409)3.17191031
23Absent hand (HP:0004050)3.05172359
24Cerebral hemorrhage (HP:0001342)3.00498120
25Abnormality of the vasculature of the conjunctiva (HP:0008054)2.93103976
26Hyporeflexia of lower limbs (HP:0002600)2.91020272
27Calcaneovalgus deformity (HP:0001848)2.88326452
28Menorrhagia (HP:0000132)2.86049703
29Abnormality of the hepatic vasculature (HP:0006707)2.83633751
30Hemangiomatosis (HP:0007461)2.81726976
31Increased connective tissue (HP:0009025)2.80735658
32Visceral angiomatosis (HP:0100761)2.77667622
33Distal lower limb muscle weakness (HP:0009053)2.74406735
34Protrusio acetabuli (HP:0003179)2.69212577
35Stroke (HP:0001297)2.64171735
36Systemic lupus erythematosus (HP:0002725)2.63793247
37Difficulty climbing stairs (HP:0003551)2.63344238
38Capillary hemangiomas (HP:0005306)2.61837911
39Overgrowth (HP:0001548)2.57762640
40Spinal rigidity (HP:0003306)2.53467836
41Bicuspid aortic valve (HP:0001647)2.52682276
42Vertebral clefting (HP:0008428)2.52161366
43Aplasia cutis congenita (HP:0001057)2.51906027
44Myocardial infarction (HP:0001658)2.51484500
45Adactyly (HP:0009776)2.50668544
46Segmental peripheral demyelination/remyelination (HP:0003481)2.49378505
47Premature rupture of membranes (HP:0001788)2.48725512
48Deformed tarsal bones (HP:0008119)2.47153349
49Porencephaly (HP:0002132)2.46524206
50Subacute progressive viral hepatitis (HP:0006572)2.46068134
51Inflammation of the large intestine (HP:0002037)2.45757905
52Abnormality of the calcaneus (HP:0008364)2.44354842
53Aneurysm (HP:0002617)2.43042692
54Mucosal telangiectasiae (HP:0100579)2.38218365
55Muscle fiber splitting (HP:0003555)2.32848551
56Abnormal umbilical cord blood vessels (HP:0011403)2.32545241
57Single umbilical artery (HP:0001195)2.32545241
58Abnormality of the fetal cardiovascular system (HP:0010948)2.32545241
59Atrophic scars (HP:0001075)2.31292007
60Delayed CNS myelination (HP:0002188)2.29326847
61Hip contracture (HP:0003273)2.29274799
62Cervical subluxation (HP:0003308)2.28875163
63Ventricular tachycardia (HP:0004756)2.26289566
64Gastrointestinal inflammation (HP:0004386)2.23169953
65Difficulty running (HP:0009046)2.22254385
66Mitral valve prolapse (HP:0001634)2.21409347
67Abnormal vertebral ossification (HP:0100569)2.20309978
68Mesangial abnormality (HP:0001966)2.18560210
69Bifid uvula (HP:0000193)2.17422456
70High pitched voice (HP:0001620)2.17131807
71Centrally nucleated skeletal muscle fibers (HP:0003687)2.15419501
72Venous insufficiency (HP:0005293)2.14872320
73Hemorrhage of the eye (HP:0011885)2.14361758
74Joint hemorrhage (HP:0005261)2.12036506
75Pulmonary hypertension (HP:0002092)2.11947927
76Cavernous hemangioma (HP:0001048)2.10629631
77Nemaline bodies (HP:0003798)2.10600687
78Onycholysis (HP:0001806)2.10378581
79Short nail (HP:0001799)2.10134917
80EMG: myopathic abnormalities (HP:0003458)2.09333119
81Hypoplasia of the iris (HP:0007676)2.08488978
82Limited hip movement (HP:0008800)2.08435328
83Neonatal death (HP:0003811)2.07010494
84Stenosis of the external auditory canal (HP:0000402)2.06684370
85Subcapsular cataract (HP:0000523)2.04817106
86Increased variability in muscle fiber diameter (HP:0003557)2.03214513
87Hyperlipoproteinemia (HP:0010980)2.02320614
88Skull defect (HP:0001362)2.01860868
89Hemiplegia (HP:0002301)2.01584446
90Absent eyebrow (HP:0002223)2.01068293
91Prolonged bleeding time (HP:0003010)2.00383657
92Microcytic anemia (HP:0001935)1.98093894
93Ectopia lentis (HP:0001083)1.97943896
94Bulbous nose (HP:0000414)1.97586166
95Abnormality of skeletal muscle fiber size (HP:0012084)1.97166697
96Pulmonary artery stenosis (HP:0004415)1.97119288
97Right ventricular cardiomyopathy (HP:0011663)1.96492760
98Atrial fibrillation (HP:0005110)1.96066190
99Venous abnormality (HP:0002624)1.95402459
100Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.95230164
101Abnormality of the axillary hair (HP:0100134)1.95089186
102Abnormality of secondary sexual hair (HP:0009888)1.95089186
103Reduced subcutaneous adipose tissue (HP:0003758)1.94359643
104Pigmentary retinal degeneration (HP:0001146)1.94037371
105Joint stiffness (HP:0001387)1.93965259
106Spondylolisthesis (HP:0003302)1.93742515
107Scotoma (HP:0000575)1.92648743
108Short 4th metacarpal (HP:0010044)1.92566812
109Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.92566812
110Full cheeks (HP:0000293)1.90612402
111Supraventricular arrhythmia (HP:0005115)1.89524048
112Milia (HP:0001056)1.87267786
113Aortic valve stenosis (HP:0001650)1.86776920
114Muscle fiber inclusion bodies (HP:0100299)1.86764833
115Intestinal atresia (HP:0011100)1.86649314
116Distal arthrogryposis (HP:0005684)1.86589564
117Fragile skin (HP:0001030)1.85532592
118Glomerulonephritis (HP:0000099)1.85186402
119Areflexia of lower limbs (HP:0002522)1.83950889
120Coxa vara (HP:0002812)1.82804191
121Pulmonary embolism (HP:0002204)1.82643712
122Lipoatrophy (HP:0100578)1.82405906
123Weak cry (HP:0001612)1.81901146
124Abnormality of the intrinsic pathway (HP:0010989)1.81886572
125Intestinal polyposis (HP:0200008)1.81452412
126Flexion contracture of toe (HP:0005830)1.80268924
127Joint contractures involving the joints of the feet (HP:0100492)1.80268924
128Glossoptosis (HP:0000162)1.79792514
129Wormian bones (HP:0002645)1.78963359
130Nuclear cataract (HP:0100018)1.78209917
131Bladder diverticulum (HP:0000015)1.77191898
132Hydroureter (HP:0000072)1.76725729
133Asymmetric septal hypertrophy (HP:0001670)1.74545744
134Intestinal polyp (HP:0005266)1.74482196
135Distal lower limb amyotrophy (HP:0008944)1.74479627
136Disproportionate tall stature (HP:0001519)1.74440917
137Primary atrial arrhythmia (HP:0001692)1.74222659
138Soft skin (HP:0000977)1.73206455
139Camptodactyly of toe (HP:0001836)1.73201495
140Teleangiectasia of the skin (HP:0100585)1.72911790
141Lymphedema (HP:0001004)1.72331607
142Shallow orbits (HP:0000586)1.70042208
143Axonal loss (HP:0003447)1.69178764
144Abnormal platelet function (HP:0011869)1.68981358
145Impaired platelet aggregation (HP:0003540)1.68981358

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE19.14982562
2KDR6.30244106
3TGFBR25.70985539
4TGFBR13.58931915
5PDK22.81921870
6MYLK2.02470990
7PTK2B2.01688546
8EPHB21.96331477
9MAP2K31.79770373
10RIPK11.77426894
11MAP3K31.62337925
12MAPK121.57420223
13PTK61.57116014
14PAK41.56060140
15FER1.55160234
16GRK11.47557820
17AKT31.47157259
18PKN21.43127137
19ERN11.30039631
20MAP3K141.29584942
21MAPK151.28767754
22PRKG21.22137123
23EPHA21.16270265
24NTRK11.14755717
25MAPK71.11098071
26TSSK61.10965818
27TBK10.99182661
28CDK80.96492288
29CLK10.94792485
30MAPKAPK30.94310790
31NEK60.91964336
32BMPR1B0.84559654
33PAK20.78388186
34NUAK10.74602197
35DMPK0.74421550
36TEC0.73276622
37EPHB10.72726242
38LATS20.72719307
39STK100.72001568
40CSK0.71799654
41LRRK20.71588049
42IKBKE0.67893425
43PIM20.67072153
44IGF1R0.61321868
45FLT30.61096128
46MATK0.60778822
47ROCK20.59994717
48PTK20.58753760
49JAK30.58101312
50TESK10.58056161
51NLK0.56723996
52PRKD30.56120248
53LIMK10.56039977
54FGFR30.55457639
55GRK70.53748427
56FRK0.53198787
57ARAF0.53029494
58FGFR40.51980737
59TTN0.51878854
60CHUK0.51060126
61INSRR0.49956553
62TYK20.49640555
63PRKD10.48799342
64EGFR0.46615320
65FES0.45865605
66MAPKAPK50.45645866
67KIT0.45472551
68DAPK30.44883920
69EIF2AK30.44754693
70ERBB40.44324182
71PIK3CA0.43563085
72MAP2K20.43416840
73ERBB30.43353575
74IRAK30.42544988
75IKBKB0.42173987
76FGFR20.40586794
77GRK50.39294321
78GSK3A0.38045677
79STK30.37911375
80OBSCN0.36995819
81MAP3K60.35736180
82PIK3CG0.35462281
83CDK60.34862240
84RPS6KA40.33717792
85INSR0.32637947
86ZAK0.30580127
87EIF2AK20.30551201
88NEK90.30349629
89STK390.30162249
90EEF2K0.29846673
91LATS10.29705746
92ILK0.29010184
93PDGFRA0.28968022
94ABL20.28754907
95SRC0.28662247
96MAP3K130.28333135
97MAP3K120.27293335
98PLK20.26901206
99MAPK40.25734393
100MAP3K110.25049395
101ROCK10.24859154
102YES10.24067736
103PRKCH0.24044285
104MOS0.23900608
105ITK0.23641191
106VRK20.23090086
107HCK0.22782386
108PDGFRB0.22271101
109PRKCE0.21910556
110MARK30.20806650
111VRK10.20781188
112MAP2K10.20671517
113CDK90.20398941
114MET0.20361949
115CSF1R0.19805946
116TRPM70.19753681
117CAMK40.19010810
118ZAP700.18901041
119ABL10.18527867
120PRKAA20.18474599
121MAPKAPK20.18214359
122BCR0.18110541
123FGR0.15838842
124BTK0.11967003
125DAPK10.09738612
126FGFR10.09619375
127RPS6KA20.08444199
128ADRBK10.07419014
129IRAK10.07207285
130CDC42BPA0.06433571
131PLK30.05855610
132DDR20.05818392
133LCK0.05192966
134PRKG10.03818050
135MAP3K10.03449354
136CAMK2A0.02808376
137MAP3K80.01680681

Predicted pathways (KEGG)

RankGene SetZ-score
1Leukocyte transendothelial migration_Homo sapiens_hsa046702.91783497
2Adherens junction_Homo sapiens_hsa045202.78688016
3Malaria_Homo sapiens_hsa051442.56118451
4Focal adhesion_Homo sapiens_hsa045102.43578951
5ECM-receptor interaction_Homo sapiens_hsa045122.33160295
6AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.25378160
7Cell adhesion molecules (CAMs)_Homo sapiens_hsa045142.06793267
8Platelet activation_Homo sapiens_hsa046112.02434577
9Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.94805180
10Dilated cardiomyopathy_Homo sapiens_hsa054141.90049053
11Rap1 signaling pathway_Homo sapiens_hsa040151.87797560
12Staphylococcus aureus infection_Homo sapiens_hsa051501.85305214
13Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.80189495
14Complement and coagulation cascades_Homo sapiens_hsa046101.70809596
15African trypanosomiasis_Homo sapiens_hsa051431.70457430
16Viral myocarditis_Homo sapiens_hsa054161.70281049
17Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.65953056
18Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.59939727
19Tight junction_Homo sapiens_hsa045301.59128911
20TGF-beta signaling pathway_Homo sapiens_hsa043501.58908056
21Toxoplasmosis_Homo sapiens_hsa051451.53392031
22Small cell lung cancer_Homo sapiens_hsa052221.52875333
23PI3K-Akt signaling pathway_Homo sapiens_hsa041511.49672607
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.49188882
25Shigellosis_Homo sapiens_hsa051311.47433429
26Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.47150139
27TNF signaling pathway_Homo sapiens_hsa046681.45025767
28Hematopoietic cell lineage_Homo sapiens_hsa046401.44215078
29Renin-angiotensin system_Homo sapiens_hsa046141.43983942
30Proteoglycans in cancer_Homo sapiens_hsa052051.36466444
31Pertussis_Homo sapiens_hsa051331.36396061
32Arginine biosynthesis_Homo sapiens_hsa002201.35020721
33Vascular smooth muscle contraction_Homo sapiens_hsa042701.32195714
34Notch signaling pathway_Homo sapiens_hsa043301.29390637
35Proteasome_Homo sapiens_hsa030501.28402980
36Leishmaniasis_Homo sapiens_hsa051401.28048263
37Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.26792953
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.25708488
39Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.23522712
40HIF-1 signaling pathway_Homo sapiens_hsa040661.22675100
41Osteoclast differentiation_Homo sapiens_hsa043801.22442733
42Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.20345110
43Pathways in cancer_Homo sapiens_hsa052001.19209229
44Salmonella infection_Homo sapiens_hsa051321.12982968
45Glutathione metabolism_Homo sapiens_hsa004801.10961254
46Amoebiasis_Homo sapiens_hsa051461.10107000
47Regulation of actin cytoskeleton_Homo sapiens_hsa048101.06999526
48NF-kappa B signaling pathway_Homo sapiens_hsa040641.06522344
49Transcriptional misregulation in cancer_Homo sapiens_hsa052021.06250138
50Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.02926220
51Ras signaling pathway_Homo sapiens_hsa040141.02738082
52Legionellosis_Homo sapiens_hsa051341.02407994
53Glycosaminoglycan degradation_Homo sapiens_hsa005311.01064402
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.00021266
55Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.98548334
56Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.97100000
57Other glycan degradation_Homo sapiens_hsa005110.96910067
58Vitamin digestion and absorption_Homo sapiens_hsa049770.96882452
59Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.96251176
60Thyroid cancer_Homo sapiens_hsa052160.95796118
61Hippo signaling pathway_Homo sapiens_hsa043900.93760188
62HTLV-I infection_Homo sapiens_hsa051660.91366629
63Toll-like receptor signaling pathway_Homo sapiens_hsa046200.91178874
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.90985676
65Hepatitis C_Homo sapiens_hsa051600.90322246
66Sulfur metabolism_Homo sapiens_hsa009200.87990700
67Measles_Homo sapiens_hsa051620.86811969
68B cell receptor signaling pathway_Homo sapiens_hsa046620.86230084
69Prostate cancer_Homo sapiens_hsa052150.85098757
70Bladder cancer_Homo sapiens_hsa052190.84282834
71Chronic myeloid leukemia_Homo sapiens_hsa052200.83717417
72Influenza A_Homo sapiens_hsa051640.82621550
73Renal cell carcinoma_Homo sapiens_hsa052110.78319704
74Protein digestion and absorption_Homo sapiens_hsa049740.77687393
75Ribosome_Homo sapiens_hsa030100.77610039
76Melanogenesis_Homo sapiens_hsa049160.76270167
77N-Glycan biosynthesis_Homo sapiens_hsa005100.74594977
78Jak-STAT signaling pathway_Homo sapiens_hsa046300.74312363
79VEGF signaling pathway_Homo sapiens_hsa043700.74156897
80Antigen processing and presentation_Homo sapiens_hsa046120.72896295
81Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.72851713
82Axon guidance_Homo sapiens_hsa043600.71078408
83Apoptosis_Homo sapiens_hsa042100.70987547
84Serotonergic synapse_Homo sapiens_hsa047260.70111471
85Gap junction_Homo sapiens_hsa045400.69518417
86Hepatitis B_Homo sapiens_hsa051610.69429788
87MicroRNAs in cancer_Homo sapiens_hsa052060.68986258
88Ovarian steroidogenesis_Homo sapiens_hsa049130.68503889
89Arachidonic acid metabolism_Homo sapiens_hsa005900.68345263
90PPAR signaling pathway_Homo sapiens_hsa033200.65040851
91cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64938970
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63237811
93Estrogen signaling pathway_Homo sapiens_hsa049150.62221024
94cAMP signaling pathway_Homo sapiens_hsa040240.60582882
95Endocytosis_Homo sapiens_hsa041440.59413059
96Insulin resistance_Homo sapiens_hsa049310.59003971
97Pancreatic cancer_Homo sapiens_hsa052120.58929169
98Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.57405765
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55000828
100Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.53522043
101Basal cell carcinoma_Homo sapiens_hsa052170.53302021
102Prion diseases_Homo sapiens_hsa050200.52969466
103Dorso-ventral axis formation_Homo sapiens_hsa043200.52572017
104Phospholipase D signaling pathway_Homo sapiens_hsa040720.51678876
105NOD-like receptor signaling pathway_Homo sapiens_hsa046210.50719634
106Protein export_Homo sapiens_hsa030600.48519938
107FoxO signaling pathway_Homo sapiens_hsa040680.48481276
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46803522
109Oxytocin signaling pathway_Homo sapiens_hsa049210.45086235
110Renin secretion_Homo sapiens_hsa049240.44780531
111Chemokine signaling pathway_Homo sapiens_hsa040620.44432437
112Vibrio cholerae infection_Homo sapiens_hsa051100.44208062
113Aldosterone synthesis and secretion_Homo sapiens_hsa049250.43747019
114Bile secretion_Homo sapiens_hsa049760.42998331
115Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42567839
116Fatty acid elongation_Homo sapiens_hsa000620.42212849
117Rheumatoid arthritis_Homo sapiens_hsa053230.41596313
118Glycerolipid metabolism_Homo sapiens_hsa005610.41393497
119Colorectal cancer_Homo sapiens_hsa052100.39766515
120Alzheimers disease_Homo sapiens_hsa050100.36541770
121Morphine addiction_Homo sapiens_hsa050320.36184815
122Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.35614007
1232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.34880795
124GnRH signaling pathway_Homo sapiens_hsa049120.34681632
125Thyroid hormone synthesis_Homo sapiens_hsa049180.33196806
126Hedgehog signaling pathway_Homo sapiens_hsa043400.33063341
127Pentose phosphate pathway_Homo sapiens_hsa000300.31951471
128Glutamatergic synapse_Homo sapiens_hsa047240.30611604
129Sphingolipid signaling pathway_Homo sapiens_hsa040710.29258537
130MAPK signaling pathway_Homo sapiens_hsa040100.26258025
131p53 signaling pathway_Homo sapiens_hsa041150.22146004
132Arginine and proline metabolism_Homo sapiens_hsa003300.21577817
133Phagosome_Homo sapiens_hsa041450.21095976
134Cardiac muscle contraction_Homo sapiens_hsa042600.19925685
135Parkinsons disease_Homo sapiens_hsa050120.19333432

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