ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	tricarboxylic acid cycle (GO:0006099)	6.30220713
2	NADH metabolic process (GO:0006734)	5.85359576
3	creatine metabolic process (GO:0006600)	5.28011506
4	peptidyl-arginine omega-N-methylation (GO:0035247)	5.17992579
5	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.15415465
6	lysine metabolic process (GO:0006553)	5.07341577
7	lysine catabolic process (GO:0006554)	5.07341577
8	oxidative phosphorylation (GO:0006119)	4.95097382
9	succinate metabolic process (GO:0006105)	4.78262402
10	oxaloacetate metabolic process (GO:0006107)	4.77085486
11	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.71374752
12	ATP synthesis coupled proton transport (GO:0015986)	4.71374752
13	aspartate family amino acid catabolic process (GO:0009068)	4.56266086
14	histone arginine methylation (GO:0034969)	4.52297873
15	2-oxoglutarate metabolic process (GO:0006103)	4.51161721
16	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.50159739
17	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	4.40780824
18	respiratory electron transport chain (GO:0022904)	4.40595045
19	peptidyl-arginine methylation (GO:0018216)	4.33870279
20	peptidyl-arginine N-methylation (GO:0035246)	4.33870279
21	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	4.29733535
22	cellular ketone body metabolic process (GO:0046950)	4.29669422
23	electron transport chain (GO:0022900)	4.28749145
24	glyoxylate metabolic process (GO:0046487)	4.26129779
25	regulation of acyl-CoA biosynthetic process (GO:0050812)	4.14878326
26	carnitine shuttle (GO:0006853)	4.10128142
27	ribosomal small subunit biogenesis (GO:0042274)	4.08502260
28	branched-chain amino acid catabolic process (GO:0009083)	4.06778525
29	L-phenylalanine metabolic process (GO:0006558)	3.97675382
30	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	3.97675382
31	proline biosynthetic process (GO:0006561)	3.95476747
32	regulation of coenzyme metabolic process (GO:0051196)	3.94596105
33	regulation of cofactor metabolic process (GO:0051193)	3.94596105
34	mitochondrial fusion (GO:0008053)	3.89991680
35	metallo-sulfur cluster assembly (GO:0031163)	3.89868695
36	iron-sulfur cluster assembly (GO:0016226)	3.89868695
37	fatty acid beta-oxidation (GO:0006635)	3.85474669
38	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	3.81373570
39	L-phenylalanine catabolic process (GO:0006559)	3.81373570
40	GDP-mannose metabolic process (GO:0019673)	3.79566217
41	fatty acid transmembrane transport (GO:1902001)	3.76369922
42	actin-mediated cell contraction (GO:0070252)	3.76194608
43	formation of translation preinitiation complex (GO:0001731)	3.75326133
44	ketone body metabolic process (GO:1902224)	3.72827890
45	glycine metabolic process (GO:0006544)	3.72375586
46	cardiac muscle contraction (GO:0060048)	3.67129211
47	branched-chain amino acid metabolic process (GO:0009081)	3.65159759
48	acetyl-CoA metabolic process (GO:0006084)	3.64784849
49	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.64437395
50	biotin metabolic process (GO:0006768)	3.62082855
51	amino-acid betaine metabolic process (GO:0006577)	3.61752602
52	protein insertion into membrane (GO:0051205)	3.61438271
53	short-chain fatty acid metabolic process (GO:0046459)	3.61324364
54	serine family amino acid catabolic process (GO:0009071)	3.61255012
55	sarcomere organization (GO:0045214)	3.57543572
56	serine family amino acid biosynthetic process (GO:0009070)	3.52893094
57	fatty acid catabolic process (GO:0009062)	3.50903296
58	sarcoplasmic reticulum calcium ion transport (GO:0070296)	3.50877241
59	kynurenine metabolic process (GO:0070189)	3.49801120
60	tricarboxylic acid metabolic process (GO:0072350)	3.46003982
61	glycolytic process (GO:0006096)	3.45515778
62	striated muscle contraction (GO:0006941)	3.45003672
63	aromatic amino acid family catabolic process (GO:0009074)	3.44078513
64	positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)	3.44067751
65	fatty acid oxidation (GO:0019395)	3.41072707
66	cysteine metabolic process (GO:0006534)	3.39201834
67	establishment of mitochondrion localization (GO:0051654)	3.39025737
68	serine family amino acid metabolic process (GO:0009069)	3.38051851
69	ribosomal small subunit assembly (GO:0000028)	3.35643527
70	carnitine metabolic process (GO:0009437)	3.35366359
71	fatty acid homeostasis (GO:0055089)	3.34032950
72	lipid oxidation (GO:0034440)	3.32618596
73	alpha-amino acid catabolic process (GO:1901606)	3.30695274
74	gonadal mesoderm development (GO:0007506)	3.29566272
75	ATP biosynthetic process (GO:0006754)	3.29130804
76	skeletal muscle contraction (GO:0003009)	3.27319896
77	gluconeogenesis (GO:0006094)	3.26618536
78	protein targeting to mitochondrion (GO:0006626)	3.26308426
79	quinone biosynthetic process (GO:1901663)	3.25711618
80	ubiquinone biosynthetic process (GO:0006744)	3.25711618
81	NAD metabolic process (GO:0019674)	3.24741598
82	monocarboxylic acid catabolic process (GO:0072329)	3.24304482
83	valine metabolic process (GO:0006573)	3.24070001
84	viral transcription (GO:0019083)	3.23211412
85	mitochondrion transport along microtubule (GO:0047497)	3.23106153
86	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	3.23106153
87	aspartate family amino acid metabolic process (GO:0009066)	3.22201059
88	amino-acid betaine transport (GO:0015838)	3.18487128
89	carnitine transport (GO:0015879)	3.18487128
90	L-methionine salvage (GO:0071267)	3.18276571
91	L-methionine biosynthetic process (GO:0071265)	3.18276571
92	amino acid salvage (GO:0043102)	3.18276571
93	cellular amino acid catabolic process (GO:0009063)	3.17737519
94	carnitine transmembrane transport (GO:1902603)	3.16119491
95	aerobic respiration (GO:0009060)	3.15296603
96	indolalkylamine catabolic process (GO:0046218)	3.14904274
97	tryptophan catabolic process (GO:0006569)	3.14904274
98	indole-containing compound catabolic process (GO:0042436)	3.14904274
99	muscle filament sliding (GO:0030049)	3.14862106
100	actin-myosin filament sliding (GO:0033275)	3.14862106
101	hexose biosynthetic process (GO:0019319)	3.14603337
102	regulation of oxidative phosphorylation (GO:0002082)	3.14125130
103	L-serine metabolic process (GO:0006563)	3.13652644
104	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.13442684
105	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.13442684
106	NADH dehydrogenase complex assembly (GO:0010257)	3.13442684
107	regulation of mitochondrial translation (GO:0070129)	3.10396874
108	regulation of translational fidelity (GO:0006450)	3.10388831
109	proline metabolic process (GO:0006560)	3.10111307
110	coenzyme catabolic process (GO:0009109)	3.08268320
111	regulation of sulfur metabolic process (GO:0042762)	3.07525279
112	carboxylic acid catabolic process (GO:0046395)	3.06634313
113	organic acid catabolic process (GO:0016054)	3.06634313
114	purine ribonucleoside monophosphate biosynthetic process (GO:0009168)	3.05269259
115	purine nucleoside monophosphate biosynthetic process (GO:0009127)	3.05269259
116	dicarboxylic acid metabolic process (GO:0043648)	3.03287729
117	translational elongation (GO:0006414)	3.03185253
118	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	3.02785207
119	protein maturation by protein folding (GO:0022417)	3.01846175
120	establishment of protein localization to mitochondrion (GO:0072655)	3.01586931
121	negative regulation of necroptotic process (GO:0060546)	2.99800612
122	purine nucleobase biosynthetic process (GO:0009113)	2.98931130
123	regulation of skeletal muscle contraction (GO:0014819)	2.98536764
124	sulfur amino acid catabolic process (GO:0000098)	2.98522946
125	protein complex biogenesis (GO:0070271)	2.98113383
126	regulation of mammary gland epithelial cell proliferation (GO:0033599)	2.97899348
127	ribosomal large subunit biogenesis (GO:0042273)	2.97535631
128	inner mitochondrial membrane organization (GO:0007007)	2.97414926
129	regulation of cellular respiration (GO:0043457)	2.96599315
130	mitochondrial respiratory chain complex assembly (GO:0033108)	2.95932565
131	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.95269534
132	response to mercury ion (GO:0046689)	2.94556066
133	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.94429979
134	cardiac myofibril assembly (GO:0055003)	2.94062733
135	ribonucleoprotein complex biogenesis (GO:0022613)	2.93683419
136	galactose catabolic process (GO:0019388)	2.93414577
137	translational termination (GO:0006415)	2.91729659
138	sulfur amino acid biosynthetic process (GO:0000097)	2.91316802
139	regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)	2.90674190
140	regulation of relaxation of muscle (GO:1901077)	2.88912253
141	mitochondrial fragmentation involved in apoptotic process (GO:0043653)	2.88836133
142	regulation of sequestering of triglyceride (GO:0010889)	2.88661345
143	positive regulation of mitochondrial fission (GO:0090141)	2.88223426
144	homocysteine metabolic process (GO:0050667)	2.87870802
145	monosaccharide biosynthetic process (GO:0046364)	2.87812497
146	regulation of fatty acid oxidation (GO:0046320)	2.87392472
147	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)	2.87155017
148	nucleoside diphosphate biosynthetic process (GO:0009133)	2.84001617
149	peptidyl-arginine modification (GO:0018195)	2.81422416
150	regulation of actin filament-based movement (GO:1903115)	2.80006905
151	myofibril assembly (GO:0030239)	2.78820915
152	protein localization to mitochondrion (GO:0070585)	2.78587139
153	negative regulation of necrotic cell death (GO:0060547)	2.78439849
154	ubiquinone metabolic process (GO:0006743)	2.77652588
155	heme biosynthetic process (GO:0006783)	2.77423532
156	negative regulation of cell size (GO:0045792)	2.76214135
157	nuclear envelope reassembly (GO:0031468)	2.74176665
158	mitotic nuclear envelope reassembly (GO:0007084)	2.74176665
159	protoporphyrinogen IX biosynthetic process (GO:0006782)	2.73952679
160	heart contraction (GO:0060047)	2.73503969
161	heart process (GO:0003015)	2.73503969
162	porphyrin-containing compound biosynthetic process (GO:0006779)	2.73212584
163	regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)	2.71843366
164	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.69554485
165	rRNA transcription (GO:0009303)	2.68096895
166	pentose metabolic process (GO:0019321)	2.67307547
167	response to stimulus involved in regulation of muscle adaptation (GO:0014874)	2.65192820
168	negative regulation of release of cytochrome c from mitochondria (GO:0090201)	2.64922018
169	cellular component biogenesis (GO:0044085)	2.63928614
170	peptidyl-histidine modification (GO:0018202)	2.62806893
171	ribosome biogenesis (GO:0042254)	2.62590038
172	guanosine-containing compound biosynthetic process (GO:1901070)	2.61737556
173	mitochondrion localization (GO:0051646)	2.60015168
174	cullin deneddylation (GO:0010388)	2.59573611
175	glucan biosynthetic process (GO:0009250)	2.58794066
176	glycogen biosynthetic process (GO:0005978)	2.58794066
177	pyruvate metabolic process (GO:0006090)	2.55734835

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	5.54370480
2	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	5.39702385
3	* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	4.05626782
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.72437613
5	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.59554871
6	* ESRRB_18555785_ChIP-Seq_MESCs_Mouse	3.47441938
7	RXR_22158963_ChIP-Seq_LIVER_Mouse	3.40196795
8	PPARA_22158963_ChIP-Seq_LIVER_Mouse	3.23161024
9	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.21168397
10	* MYC_18555785_ChIP-Seq_MESCs_Mouse	2.93997520
11	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.93947980
12	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.90292718
13	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.85907101
14	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.85234273
15	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	2.83900293
16	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.78724874
17	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.73993010
18	* MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.64711404
19	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.53221440
20	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.51585057
21	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.49341432
22	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	2.42341670
23	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.42341186
24	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.35695971
25	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.29388027
26	VDR_21846776_ChIP-Seq_THP-1_Human	2.20988047
27	LXR_22158963_ChIP-Seq_LIVER_Mouse	2.17755744
28	LXR_22292898_ChIP-Seq_THP-1_Human	2.15421467
29	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.13376065
30	YY1_21170310_ChIP-Seq_MESCs_Mouse	2.12339823
31	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.04088661
32	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.98191533
33	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.96165985
34	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.86797767
35	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.84347178
36	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.84236935
37	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.83976197
38	MYC_22102868_ChIP-Seq_BL_Human	1.82010365
39	GABP_19822575_ChIP-Seq_HepG2_Human	1.74946060
40	VDR_23849224_ChIP-Seq_CD4+_Human	1.70731561
41	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.66955161
42	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.65905681
43	FOXP3_21729870_ChIP-Seq_TREG_Human	1.65594927
44	XRN2_22483619_ChIP-Seq_HELA_Human	1.61798917
45	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.61443805
46	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.61434823
47	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.61056938
48	DCP1A_22483619_ChIP-Seq_HELA_Human	1.59296596
49	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.57164733
50	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.54873165
51	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.51498833
52	* RACK7_27058665_Chip-Seq_MCF-7_Human	1.50159933
53	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.48657557
54	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.46556785
55	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.45058821
56	E2F7_22180533_ChIP-Seq_HELA_Human	1.44007669
57	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.41384126
58	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.40712724
59	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.40102201
60	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.38030720
61	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.37863385
62	CIITA_25753668_ChIP-Seq_RAJI_Human	1.37120430
63	* SA1_27219007_Chip-Seq_ERYTHROID_Human	1.36525177
64	ZNF263_19887448_ChIP-Seq_K562_Human	1.34066930
65	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.33566348
66	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.32554255
67	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.32091722
68	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.31290702
69	* CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.29278620
70	SMC4_20622854_ChIP-Seq_HELA_Human	1.26067729
71	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.24191790
72	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	1.23880022
73	KDM2B_26808549_Chip-Seq_DND41_Human	1.22143716
74	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.21458016
75	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.20244019
76	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.19270317
77	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.18998695
78	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.16982110
79	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.16299584
80	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.16271918
81	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.15045541
82	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.14529382
83	CTCF_26484167_Chip-Seq_Bcells_Mouse	1.14014697
84	SETDB1_19884255_ChIP-Seq_MESCs_Mouse	1.13794780
85	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.13591536
86	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.12979762
87	TBX5_21415370_ChIP-Seq_HL-1_Mouse	1.12839625
88	CTCF_21964334_Chip-Seq_Bcells_Human	1.11850481
89	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.11076226
90	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.10005539
91	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.09592747
92	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.09244308
93	ZFP281_18757296_ChIP-ChIP_E14_Mouse	1.08554327
94	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.07883697
95	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.07255433
96	* CTCF_27219007_Chip-Seq_Bcells_Human	1.06411695
97	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.06021526
98	SA1_27219007_Chip-Seq_Bcells_Human	1.05930828
99	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.05604706
100	MAF_26560356_Chip-Seq_TH2_Human	1.04839545
101	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.04187847
102	CREB1_26743006_Chip-Seq_LNCaP_Human	1.04180999
103	BCL6_27268052_Chip-Seq_Bcells_Human	1.01698414
104	GATA4_21415370_ChIP-Seq_HL-1_Mouse	1.01536601
105	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.00503373
106	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.00266054
107	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	0.99936547
108	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.99181574
109	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.98321849
110	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.97933623
111	KDM5A_27292631_Chip-Seq_BREAST_Human	0.97842354
112	AR_21909140_ChIP-Seq_LNCAP_Human	0.96188553
113	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	0.92340186
114	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.91605383
115	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.91087779
116	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.89827061
117	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.89786233
118	TTF2_22483619_ChIP-Seq_HELA_Human	0.89611929
119	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.85865190
120	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.85345468
121	HTT_18923047_ChIP-ChIP_STHdh_Human	0.84162246
122	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.83907696
123	OCT4_18692474_ChIP-Seq_MEFs_Mouse	0.83489469
124	RXRA_24833708_ChIP-Seq_LIVER_Mouse	0.83370710
125	KLF4_18555785_ChIP-Seq_MESCs_Mouse	0.83085298
126	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.82856161
127	P68_20966046_ChIP-Seq_HELA_Human	0.82086985
128	BCOR_27268052_Chip-Seq_Bcells_Human	0.80992835
129	E2F1_20622854_ChIP-Seq_HELA_Human	0.80597326
130	ERA_21632823_ChIP-Seq_H3396_Human	0.78307826
131	PHF8_20622854_ChIP-Seq_HELA_Human	0.78143900
132	E2F4_17652178_ChIP-ChIP_JURKAT_Human	0.77023901
133	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.76329733
134	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	0.75888870
135	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	0.75503920
136	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.73731851

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003646_muscle_fatigue	4.91568588
2	MP0002837_dystrophic_cardiac_calcinosis	4.58531456
3	MP0003806_abnormal_nucleotide_metabolis	4.26278283
4	MP0002139_abnormal_hepatobiliary_system	4.04968901
5	MP0005360_urolithiasis	3.93984656
6	MP0005085_abnormal_gallbladder_physiolo	3.55978521
7	MP0005365_abnormal_bile_salt	3.35656973
8	MP0006036_abnormal_mitochondrial_physio	3.33885278
9	MP0000751_myopathy	3.15366635
10	MP0004084_abnormal_cardiac_muscle	3.12439036
11	MP0000749_muscle_degeneration	2.94756176
12	MP0004215_abnormal_myocardial_fiber	2.89114738
13	MP0004036_abnormal_muscle_relaxation	2.77607154
14	MP0008875_abnormal_xenobiotic_pharmacok	2.75988819
15	MP0002822_catalepsy	2.67674112
16	MP0005330_cardiomyopathy	2.47004117
17	MP0005332_abnormal_amino_acid	2.42407807
18	MP0006035_abnormal_mitochondrial_morpho	2.32520907
19	MP0004130_abnormal_muscle_cell	2.22939629
20	MP0002269_muscular_atrophy	2.12332833
21	MP0003693_abnormal_embryo_hatching	1.96687401
22	MP0004145_abnormal_muscle_electrophysio	1.88169685
23	MP0004043_abnormal_pH_regulation	1.86340230
24	MP0001764_abnormal_homeostasis	1.85940258
25	MP0008260_abnormal_autophagy	1.85750375
26	MP0000747_muscle_weakness	1.85324378
27	MP0010329_abnormal_lipoprotein_level	1.85140849
28	MP0004087_abnormal_muscle_fiber	1.77352704
29	MP0003195_calcinosis	1.75948183
30	MP0005620_abnormal_muscle_contractility	1.69510492
31	MP0000750_abnormal_muscle_regeneration	1.68217559
32	MP0005670_abnormal_white_adipose	1.64911033
33	MP0004859_abnormal_synaptic_plasticity	1.63685082
34	MP0005083_abnormal_biliary_tract	1.63450724
35	MP0005266_abnormal_metabolism	1.62394090
36	MP0002972_abnormal_cardiac_muscle	1.62373844
37	MP0009840_abnormal_foam_cell	1.62346176
38	MP0003137_abnormal_impulse_conducting	1.59620928
39	MP0003111_abnormal_nucleus_morphology	1.59534791
40	MP0005319_abnormal_enzyme/_coenzyme	1.59017218
41	MP0008775_abnormal_heart_ventricle	1.56911893
42	MP0003221_abnormal_cardiomyocyte_apopto	1.56054369
43	MP0004233_abnormal_muscle_weight	1.55418287
44	MP0002106_abnormal_muscle_physiology	1.53329838
45	MP0003252_abnormal_bile_duct	1.52169981
46	MP0001544_abnormal_cardiovascular_syste	1.47789477
47	MP0005385_cardiovascular_system_phenoty	1.47789477
48	MP0000678_abnormal_parathyroid_gland	1.43984793
49	MP0003186_abnormal_redox_activity	1.41763577
50	MP0005584_abnormal_enzyme/coenzyme_acti	1.41149003
51	MP0002118_abnormal_lipid_homeostasis	1.39322264
52	MP0004484_altered_response_of	1.39100689
53	MP0006138_congestive_heart_failure	1.38129966
54	MP0005451_abnormal_body_composition	1.36422241
55	MP0004270_analgesia	1.34185437
56	MP0001529_abnormal_vocalization	1.34156681
57	MP0001666_abnormal_nutrient_absorption	1.32849859
58	MP0009697_abnormal_copulation	1.32466048
59	MP0004147_increased_porphyrin_level	1.32044068
60	MP0009278_abnormal_bone_marrow	1.28947274
61	MP0003656_abnormal_erythrocyte_physiolo	1.28458485
62	MP0000759_abnormal_skeletal_muscle	1.28214381
63	MP0008058_abnormal_DNA_repair	1.26843429
64	MP0005058_abnormal_lysosome_morphology	1.23651930
65	MP0004085_abnormal_heartbeat	1.22138863
66	MP0008932_abnormal_embryonic_tissue	1.20100101
67	MP0004510_myositis	1.19044419
68	MP0002332_abnormal_exercise_endurance	1.18522033
69	MP0005369_muscle_phenotype	1.17157577
70	MP0001730_embryonic_growth_arrest	1.16650621
71	MP0009643_abnormal_urine_homeostasis	1.16356392
72	MP0002249_abnormal_larynx_morphology	1.16148414
73	MP0000609_abnormal_liver_physiology	1.14471776
74	MP0010630_abnormal_cardiac_muscle	1.13908635
75	MP0000003_abnormal_adipose_tissue	1.13800744
76	MP0005666_abnormal_adipose_tissue	1.05700947
77	MP0003077_abnormal_cell_cycle	1.04104565
78	MP0003329_amyloid_beta_deposits	1.04090535
79	MP0004019_abnormal_vitamin_homeostasis	1.04005851
80	MP0004858_abnormal_nervous_system	1.03103940
81	MP0005636_abnormal_mineral_homeostasis	1.01894328
82	MP0005376_homeostasis/metabolism_phenot	1.00599663
83	MP0005535_abnormal_body_temperature	1.00518966
84	MP0002876_abnormal_thyroid_physiology	0.98460684
85	MP0010030_abnormal_orbit_morphology	0.98278034
86	MP0000733_abnormal_muscle_development	0.97671016
87	MP0002078_abnormal_glucose_homeostasis	0.97473977
88	MP0000230_abnormal_systemic_arterial	0.97459335
89	MP0003191_abnormal_cellular_cholesterol	0.97401000
90	MP0002127_abnormal_cardiovascular_syste	0.96775738
91	MP0005501_abnormal_skin_physiology	0.88891630
92	MP0002132_abnormal_respiratory_system	0.86458578
93	MP0003718_maternal_effect	0.86250969
94	MP0003123_paternal_imprinting	0.85427235
95	MP0008569_lethality_at_weaning	0.81975291
96	MP0000313_abnormal_cell_death	0.80799168
97	* MP0002080_prenatal_lethality	0.79189623
98	MP0008872_abnormal_physiological_respon	0.78309292
99	MP0002971_abnormal_brown_adipose	0.77675566
100	MP0002909_abnormal_adrenal_gland	0.77080130
101	MP0005423_abnormal_somatic_nervous	0.74735624
102	MP0004142_abnormal_muscle_tone	0.74706480
103	MP0001756_abnormal_urination	0.72394438
104	MP0010094_abnormal_chromosome_stability	0.70680043
105	MP0001346_abnormal_lacrimal_gland	0.70622396
106	MP0004957_abnormal_blastocyst_morpholog	0.69081877
107	MP0003879_abnormal_hair_cell	0.66171643
108	MP0003705_abnormal_hypodermis_morpholog	0.64693948
109	MP0000598_abnormal_liver_morphology	0.63003698
110	MP0003635_abnormal_synaptic_transmissio	0.62750812
111	MP0009333_abnormal_splenocyte_physiolog	0.62372294
112	MP0009642_abnormal_blood_homeostasis	0.62083977
113	MP0000013_abnormal_adipose_tissue	0.61580619
114	MP0000358_abnormal_cell_content/	0.61240698
115	MP0003786_premature_aging	0.61198278
116	MP0008874_decreased_physiological_sensi	0.60972485
117	MP0009379_abnormal_foot_pigmentation	0.60356905
118	MP0005377_hearing/vestibular/ear_phenot	0.58931573
119	MP0003878_abnormal_ear_physiology	0.58931573
120	MP0005448_abnormal_energy_balance	0.58060073
121	MP0002796_impaired_skin_barrier	0.57135412
122	MP0001661_extended_life_span	0.56714588
123	MP0002736_abnormal_nociception_after	0.56191106
124	MP0005452_abnormal_adipose_tissue	0.55253759
125	MP0002653_abnormal_ependyma_morphology	0.55127831
126	MP0002066_abnormal_motor_capabilities/c	0.54601285
127	MP0004185_abnormal_adipocyte_glucose	0.54475996
128	MP0001765_abnormal_ion_homeostasis	0.54347792
129	MP0003953_abnormal_hormone_level	0.53998831
130	* MP0000350_abnormal_cell_proliferation	0.53882348
131	MP0002970_abnormal_white_adipose	0.53163837
132	MP0000681_abnormal_thyroid_gland	0.52371319
133	MP0005165_increased_susceptibility_to	0.51787193
134	MP0006276_abnormal_autonomic_nervous	0.51747516
135	MP0003303_peritoneal_inflammation	0.51492785
136	MP0005386_behavior/neurological_phenoty	0.51253389
137	MP0004924_abnormal_behavior	0.51253389
138	MP0001502_abnormal_circadian_rhythm	0.50405721
139	MP0002064_seizures	0.49823773
140	MP0005375_adipose_tissue_phenotype	0.49698594
141	MP0009672_abnormal_birth_weight	0.49400613
142	MP0005334_abnormal_fat_pad	0.49389685
143	MP0001672_abnormal_embryogenesis/_devel	0.49299626

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Muscle fiber inclusion bodies (HP:0100299)	5.45460217
2	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	5.32408866
3	Nemaline bodies (HP:0003798)	5.16975772
4	Myopathic facies (HP:0002058)	4.74404523
5	Abnormal mitochondria in muscle tissue (HP:0008316)	4.69831905
6	Acute necrotizing encephalopathy (HP:0006965)	4.65360286
7	Acute encephalopathy (HP:0006846)	4.59630936
8	Hepatic necrosis (HP:0002605)	4.57643286
9	Centrally nucleated skeletal muscle fibers (HP:0003687)	4.37544474
10	Myoglobinuria (HP:0002913)	4.33904200
11	Hepatocellular necrosis (HP:0001404)	4.30362385
12	Cerebral edema (HP:0002181)	4.18876969
13	Exercise-induced myalgia (HP:0003738)	4.14917619
14	Hyperglycinuria (HP:0003108)	4.14910945
15	Increased serum pyruvate (HP:0003542)	4.02711597
16	Abnormality of glycolysis (HP:0004366)	4.02711597
17	Mitochondrial inheritance (HP:0001427)	3.90551764
18	Increased CSF lactate (HP:0002490)	3.90454742
19	Type 1 muscle fiber predominance (HP:0003803)	3.82966471
20	Exercise-induced muscle cramps (HP:0003710)	3.76792540
21	Progressive macrocephaly (HP:0004481)	3.76663379
22	Abnormality of fatty-acid metabolism (HP:0004359)	3.76276019
23	Rhabdomyolysis (HP:0003201)	3.74926444
24	Dicarboxylic aciduria (HP:0003215)	3.73924036
25	Abnormality of dicarboxylic acid metabolism (HP:0010995)	3.73924036
26	Abnormality of glycine metabolism (HP:0010895)	3.72151439
27	Abnormality of serine family amino acid metabolism (HP:0010894)	3.72151439
28	Hyperammonemia (HP:0001987)	3.70109337
29	Ketoacidosis (HP:0001993)	3.64526755
30	Ketosis (HP:0001946)	3.61205299
31	Lactic acidosis (HP:0003128)	3.60344861
32	Distal lower limb muscle weakness (HP:0009053)	3.56993947
33	Hyperglycinemia (HP:0002154)	3.52085977
34	Sudden death (HP:0001699)	3.45763501
35	Gout (HP:0001997)	3.37755509
36	Calf muscle hypertrophy (HP:0008981)	3.35228196
37	Lethargy (HP:0001254)	3.29713859
38	Palpitations (HP:0001962)	3.29156850
39	Distal lower limb amyotrophy (HP:0008944)	3.23874915
40	Hypoglycemic coma (HP:0001325)	3.17018325
41	Muscle hypertrophy of the lower extremities (HP:0008968)	3.16685782
42	Increased connective tissue (HP:0009025)	3.15726241
43	Rimmed vacuoles (HP:0003805)	3.11925790
44	Ragged-red muscle fibers (HP:0003200)	3.10647370
45	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.10531106
46	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.10531106
47	Increased serum lactate (HP:0002151)	3.10527393
48	Increased muscle lipid content (HP:0009058)	3.10279121
49	Microvesicular hepatic steatosis (HP:0001414)	3.05552931
50	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	3.02150397
51	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.00359605
52	Abnormality of alanine metabolism (HP:0010916)	3.00359605
53	Hyperalaninemia (HP:0003348)	3.00359605
54	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.99298978
55	Ventricular tachycardia (HP:0004756)	2.98671028
56	Respiratory failure (HP:0002878)	2.95992352
57	Generalized aminoaciduria (HP:0002909)	2.93170609
58	Hyporeflexia of lower limbs (HP:0002600)	2.92532626
59	Neck muscle weakness (HP:0000467)	2.92476954
60	Exercise intolerance (HP:0003546)	2.87486261
61	Abnormality of serum amino acid levels (HP:0003112)	2.85144636
62	Metabolic acidosis (HP:0001942)	2.84829365
63	Increased intramyocellular lipid droplets (HP:0012240)	2.81647085
64	Round ear (HP:0100830)	2.77779812
65	Muscle fiber splitting (HP:0003555)	2.71301311
66	Abnormality of skeletal muscle fiber size (HP:0012084)	2.69943344
67	Hypobetalipoproteinemia (HP:0003563)	2.69345699
68	CNS demyelination (HP:0007305)	2.68965886
69	Reticulocytosis (HP:0001923)	2.62395348
70	Abnormality of the left ventricular outflow tract (HP:0011103)	2.51896005
71	Subaortic stenosis (HP:0001682)	2.51896005
72	Vomiting (HP:0002013)	2.51235986
73	Intrahepatic cholestasis (HP:0001406)	2.50054599
74	Pheochromocytoma (HP:0002666)	2.49614927
75	Methylmalonic aciduria (HP:0012120)	2.48611929
76	Abnormality of the foot musculature (HP:0001436)	2.45717515
77	Difficulty climbing stairs (HP:0003551)	2.45563568
78	Myokymia (HP:0002411)	2.44748589
79	Bulbar palsy (HP:0001283)	2.43495403
80	Foot dorsiflexor weakness (HP:0009027)	2.43482793
81	Lipoatrophy (HP:0100578)	2.42460859
82	Cholelithiasis (HP:0001081)	2.42098088
83	Distal arthrogryposis (HP:0005684)	2.39484024
84	Neuroendocrine neoplasm (HP:0100634)	2.39225227
85	Increased purine levels (HP:0004368)	2.38732350
86	Hyperuricemia (HP:0002149)	2.38732350
87	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.38608232
88	Abnormality of the calf musculature (HP:0001430)	2.38143972
89	Increased variability in muscle fiber diameter (HP:0003557)	2.36767141
90	Proximal tubulopathy (HP:0000114)	2.33956197
91	Hyperlipoproteinemia (HP:0010980)	2.31529623
92	Xanthomatosis (HP:0000991)	2.30708349
93	Lower limb amyotrophy (HP:0007210)	2.30595659
94	Abnormal gallbladder morphology (HP:0012437)	2.26827187
95	Ankle clonus (HP:0011448)	2.26086806
96	Lipid accumulation in hepatocytes (HP:0006561)	2.25980061
97	Abnormality of monocarboxylic acid metabolism (HP:0010996)	2.25613336
98	Progressive muscle weakness (HP:0003323)	2.22783978
99	Hypolipoproteinemia (HP:0010981)	2.20686088
100	Leukodystrophy (HP:0002415)	2.20002297
101	Abnormality of reticulocytes (HP:0004312)	2.19344937
102	Atrial fibrillation (HP:0005110)	2.19186014
103	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.18812240
104	Nausea (HP:0002018)	2.18020671
105	Myotonia (HP:0002486)	2.17406203
106	Abnormal gallbladder physiology (HP:0012438)	2.16968867
107	Cholecystitis (HP:0001082)	2.16968867
108	Cerebral hypomyelination (HP:0006808)	2.16303213
109	Conjunctival hamartoma (HP:0100780)	2.15658581
110	Asymmetric septal hypertrophy (HP:0001670)	2.15517670
111	EMG: myopathic abnormalities (HP:0003458)	2.14392169
112	Abnormal number of erythroid precursors (HP:0012131)	2.14373750
113	Abnormality of methionine metabolism (HP:0010901)	2.13561164
114	Dilated cardiomyopathy (HP:0001644)	2.13336182
115	Bundle branch block (HP:0011710)	2.12540652
116	Supraventricular tachycardia (HP:0004755)	2.12418523
117	Muscle stiffness (HP:0003552)	2.12171808
118	Abnormality of cells of the erythroid lineage (HP:0012130)	2.11625159
119	EMG: neuropathic changes (HP:0003445)	2.10913971
120	Delayed CNS myelination (HP:0002188)	2.09164064
121	Emotional lability (HP:0000712)	2.07991012
122	Progressive external ophthalmoplegia (HP:0000590)	2.05973448
123	Primary atrial arrhythmia (HP:0001692)	2.04338979
124	Hyperbilirubinemia (HP:0002904)	2.04336421
125	Truncus arteriosus (HP:0001660)	2.03844620
126	Atrioventricular block (HP:0001678)	2.03788856
127	Supraventricular arrhythmia (HP:0005115)	2.03520819
128	Abnormality of purine metabolism (HP:0004352)	2.03354310
129	Abnormality of the gallbladder (HP:0005264)	2.02493090
130	Ulnar deviation of the wrist (HP:0003049)	2.01838753
131	Muscle fiber atrophy (HP:0100295)	2.01784525
132	Hyperventilation (HP:0002883)	2.00708745
133	Limb-girdle muscle atrophy (HP:0003797)	2.00501257
134	Optic disc pallor (HP:0000543)	1.99761339
135	Prolonged partial thromboplastin time (HP:0003645)	1.99540571
136	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.99379947
137	Hypoalphalipoproteinemia (HP:0003233)	1.98785366
138	Abnormal atrioventricular conduction (HP:0005150)	1.98667933
139	Heart block (HP:0012722)	1.97503644
140	Calcaneovalgus deformity (HP:0001848)	1.97134088
141	Glycosuria (HP:0003076)	1.96811789
142	Athetosis (HP:0002305)	1.94772350
143	Mildly elevated creatine phosphokinase (HP:0008180)	1.94109306
144	Shoulder girdle muscle weakness (HP:0003547)	1.93448699
145	Back pain (HP:0003418)	1.92265165
146	Generalized muscle weakness (HP:0003324)	1.89615098
147	Achilles tendon contracture (HP:0001771)	1.88661571
148	External ophthalmoplegia (HP:0000544)	1.88064558
149	Testicular atrophy (HP:0000029)	1.85451488
150	Areflexia of lower limbs (HP:0002522)	1.84582724
151	Upper limb amyotrophy (HP:0009129)	1.82368860
152	Distal upper limb amyotrophy (HP:0007149)	1.82368860
153	Abnormality of the tricuspid valve (HP:0001702)	1.73881500
154	Deformed tarsal bones (HP:0008119)	1.73033214

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BCKDK	5.45324053
2	NEK1	4.48616077
3	PDK3	4.06635009
4	PDK4	4.06635009
5	OBSCN	3.33250493
6	SMG1	3.07642943
7	VRK2	2.96519462
8	TTN	2.60057552
9	BUB1	2.53734082
10	PHKG2	2.48702068
11	PHKG1	2.48702068
12	STK16	2.47295068
13	MYLK	2.46646187
14	PDK2	2.25043876
15	ICK	2.19010016
16	PINK1	2.18744227
17	EIF2AK1	2.16473812
18	NME1	2.16016768
19	PRPF4B	2.12649413
20	ARAF	1.98836468
21	TESK1	1.90321196
22	PRKD3	1.81886898
23	LMTK2	1.73215902
24	TSSK6	1.66029695
25	NME2	1.64791071
26	BRAF	1.58634155
27	WEE1	1.54655100
28	EEF2K	1.50310832
29	MAP3K7	1.48837703
30	IRAK3	1.47507720
31	CCNB1	1.44842473
32	TRIB3	1.44755352
33	STK38L	1.44507812
34	ERN1	1.36543844
35	PKN2	1.36093131
36	PIK3CA	1.20898263
37	AKT3	1.19297654
38	CDK19	1.08735830
39	MAP2K4	1.05652236
40	DAPK1	1.05009468
41	GRK7	1.04884779
42	MAP2K3	1.04619368
43	PAK6	1.03928887
44	FLT3	1.03716406
45	PIM2	1.02484557
46	MAP3K12	1.00964746
47	IRAK2	1.00706849
48	MAP3K11	1.00501917
49	MUSK	0.97910864
50	BRSK2	0.94856155
51	BRSK1	0.93879018
52	DYRK1B	0.92908252
53	ZAK	0.92810808
54	MAP2K2	0.92468214
55	KDR	0.92147298
56	MAPKAPK3	0.91099161
57	EIF2AK3	0.89069218
58	MAPK12	0.88836518
59	TAOK2	0.80433807
60	CSNK1G3	0.79280515
61	TAOK1	0.79263799
62	CAMKK2	0.76595156
63	MAP3K10	0.76400686
64	DAPK3	0.73682872
65	MST1R	0.72551656
66	WNK4	0.72365914
67	MAP3K8	0.72365254
68	STK24	0.71577440
69	PRKAA1	0.71232447
70	RPS6KB2	0.70255716
71	MAPK11	0.67706613
72	ILK	0.67680806
73	MAP3K4	0.64363563
74	PRKD2	0.64049617
75	SIK1	0.62921021
76	MAP2K7	0.62587435
77	PAK1	0.62242636
78	CAMK2G	0.62109766
79	CDK4	0.61813115
80	CAMK2D	0.61555113
81	CDK8	0.61137418
82	TBK1	0.60169512
83	UHMK1	0.59296604
84	WNK3	0.59258304
85	KSR2	0.59222331
86	EPHA2	0.58742489
87	DYRK2	0.55882600
88	GRK5	0.55822180
89	VRK1	0.55758842
90	MARK2	0.53899271
91	MAP3K5	0.53187036
92	MAP2K6	0.52840857
93	CDK11A	0.52772500
94	RPS6KA5	0.52631490
95	PLK4	0.52155964
96	MAP3K3	0.51855313
97	RAF1	0.51720095
98	MAP3K1	0.51679257
99	RIPK1	0.50945175
100	PLK1	0.50790577
101	AURKA	0.50230273
102	PIK3CG	0.49911676
103	CSNK1A1L	0.49799896
104	PBK	0.48288084
105	BMX	0.48113607
106	RPS6KA1	0.45385010
107	CDK14	0.44386204
108	CDK7	0.44242527
109	EPHA4	0.43826390
110	PRKCG	0.43669184
111	TNK2	0.42908006
112	PKN1	0.42498440
113	DMPK	0.42267771
114	PRKACG	0.42222406
115	CDK15	0.41854386
116	CAMK2B	0.41734369
117	MTOR	0.41477997
118	STK38	0.41287531
119	PDK1	0.41028988
120	PRKACB	0.41027584
121	TTK	0.40673581
122	LRRK2	0.39650391
123	OXSR1	0.38973574
124	PRKAA2	0.38630178
125	CDK18	0.36893164
126	SCYL2	0.36174154
127	AKT2	0.36134236
128	CSNK1G2	0.35936117
129	SRPK1	0.35899745
130	PRKD1	0.35784002
131	PDPK1	0.34847233
132	TESK2	0.34732628
133	LIMK1	0.34099998
134	TIE1	0.33811022
135	MAPK4	0.33639934
136	GRK6	0.33602904
137	PRKACA	0.33409120
138	MINK1	0.31713969
139	CAMK4	0.31549385
140	CDC7	0.31070336
141	RPS6KL1	0.30673661
142	RPS6KC1	0.30673661
143	DAPK2	0.28469021
144	RPS6KA6	0.25863162
145	AURKB	0.25490459
146	ABL2	0.25058516
147	CSNK2A1	0.24870389

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	4.37268052
2	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	3.79022100
3	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	3.45720376
4	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	3.20395639
5	Propanoate metabolism_Homo sapiens_hsa00640	2.98562363
6	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.64089315
7	Fatty acid degradation_Homo sapiens_hsa00071	2.59397951
8	Oxidative phosphorylation_Homo sapiens_hsa00190	2.58386862
9	Carbon metabolism_Homo sapiens_hsa01200	2.56147170
10	Pyruvate metabolism_Homo sapiens_hsa00620	2.50991170
11	Parkinsons disease_Homo sapiens_hsa05012	2.45066852
12	Butanoate metabolism_Homo sapiens_hsa00650	2.19267198
13	Biosynthesis of amino acids_Homo sapiens_hsa01230	2.09875279
14	Fatty acid metabolism_Homo sapiens_hsa01212	1.96573011
15	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.94680297
16	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.89872801
17	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.86411399
18	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.83649965
19	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.79959139
20	Arginine biosynthesis_Homo sapiens_hsa00220	1.79342643
21	Tryptophan metabolism_Homo sapiens_hsa00380	1.74616669
22	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.65381706
23	Cardiac muscle contraction_Homo sapiens_hsa04260	1.65315493
24	Proteasome_Homo sapiens_hsa03050	1.64702220
25	Peroxisome_Homo sapiens_hsa04146	1.58202395
26	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.56944482
27	Alzheimers disease_Homo sapiens_hsa05010	1.56292836
28	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.55643891
29	Huntingtons disease_Homo sapiens_hsa05016	1.54652301
30	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.53950488
31	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.48559583
32	Fatty acid elongation_Homo sapiens_hsa00062	1.48451524
33	beta-Alanine metabolism_Homo sapiens_hsa00410	1.48059976
34	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.46511044
35	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.44818776
36	Sulfur relay system_Homo sapiens_hsa04122	1.43694076
37	PPAR signaling pathway_Homo sapiens_hsa03320	1.24817237
38	Phenylalanine metabolism_Homo sapiens_hsa00360	1.19604465
39	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.15724087
40	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.15522914
41	Pentose phosphate pathway_Homo sapiens_hsa00030	1.10768271
42	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.10338419
43	Sulfur metabolism_Homo sapiens_hsa00920	1.08476463
44	Arginine and proline metabolism_Homo sapiens_hsa00330	1.05584324
45	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.05399502
46	Folate biosynthesis_Homo sapiens_hsa00790	1.01591281
47	Nitrogen metabolism_Homo sapiens_hsa00910	0.99925491
48	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.98202746
49	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.94343971
50	RNA polymerase_Homo sapiens_hsa03020	0.93341854
51	Tyrosine metabolism_Homo sapiens_hsa00350	0.92137486
52	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.90421305
53	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.88688458
54	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.87731549
55	Selenocompound metabolism_Homo sapiens_hsa00450	0.86303699
56	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.82671082
57	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.82527221
58	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.81919436
59	Metabolic pathways_Homo sapiens_hsa01100	0.81542998
60	Pyrimidine metabolism_Homo sapiens_hsa00240	0.78828052
61	One carbon pool by folate_Homo sapiens_hsa00670	0.77245062
62	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.76055100
63	DNA replication_Homo sapiens_hsa03030	0.74408052
64	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.71249671
65	Histidine metabolism_Homo sapiens_hsa00340	0.70537823
66	Fat digestion and absorption_Homo sapiens_hsa04975	0.68063394
67	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.66905045
68	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.64722123
69	Vibrio cholerae infection_Homo sapiens_hsa05110	0.64510945
70	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.64080445
71	Galactose metabolism_Homo sapiens_hsa00052	0.63708993
72	Chemical carcinogenesis_Homo sapiens_hsa05204	0.61819706
73	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.59137740
74	Glutathione metabolism_Homo sapiens_hsa00480	0.58577959
75	Bile secretion_Homo sapiens_hsa04976	0.56449427
76	Acute myeloid leukemia_Homo sapiens_hsa05221	0.56299902
77	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.56083372
78	Purine metabolism_Homo sapiens_hsa00230	0.56077860
79	Other glycan degradation_Homo sapiens_hsa00511	0.55258347
80	mRNA surveillance pathway_Homo sapiens_hsa03015	0.54163297
81	Ribosome_Homo sapiens_hsa03010	0.53310694
82	Retinol metabolism_Homo sapiens_hsa00830	0.50821652
83	Glucagon signaling pathway_Homo sapiens_hsa04922	0.50711772
84	Glycerolipid metabolism_Homo sapiens_hsa00561	0.50710478
85	Mismatch repair_Homo sapiens_hsa03430	0.48407290
86	Regulation of autophagy_Homo sapiens_hsa04140	0.47100521
87	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.46144127
88	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.45019531
89	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.43870305
90	Complement and coagulation cascades_Homo sapiens_hsa04610	0.41270641
91	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.41237479
92	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.39664869
93	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.39431523
94	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.38818230
95	Collecting duct acid secretion_Homo sapiens_hsa04966	0.36714008
96	Nucleotide excision repair_Homo sapiens_hsa03420	0.36509100
97	Alcoholism_Homo sapiens_hsa05034	0.35922518
98	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.35754817
99	Caffeine metabolism_Homo sapiens_hsa00232	0.33987742
100	Base excision repair_Homo sapiens_hsa03410	0.33614989
101	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.33512666
102	VEGF signaling pathway_Homo sapiens_hsa04370	0.33224236
103	RNA transport_Homo sapiens_hsa03013	0.28574193
104	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.26655902
105	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.25026616
106	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.24817526
107	Prion diseases_Homo sapiens_hsa05020	0.24627994
108	Oocyte meiosis_Homo sapiens_hsa04114	0.24317876
109	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.24264578
110	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.21997426
111	Lysine degradation_Homo sapiens_hsa00310	0.21427307
112	mTOR signaling pathway_Homo sapiens_hsa04150	0.20409736
113	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.19943364
114	Non-small cell lung cancer_Homo sapiens_hsa05223	0.19056306
115	Steroid biosynthesis_Homo sapiens_hsa00100	0.18821028
116	ABC transporters_Homo sapiens_hsa02010	0.16275882
117	Bladder cancer_Homo sapiens_hsa05219	0.15613205
118	Insulin signaling pathway_Homo sapiens_hsa04910	0.15566043
119	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.15410144
120	Homologous recombination_Homo sapiens_hsa03440	0.14010765
121	Notch signaling pathway_Homo sapiens_hsa04330	0.13975020
122	Spliceosome_Homo sapiens_hsa03040	0.13847490
123	AMPK signaling pathway_Homo sapiens_hsa04152	0.13453883
124	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.13225429
125	Insulin resistance_Homo sapiens_hsa04931	0.12317149
126	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.11473109
127	Linoleic acid metabolism_Homo sapiens_hsa00591	0.11190037
128	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.10837762
129	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.10364711
130	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.07466680

ECSIT

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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