ECT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a guanine nucleotide exchange factor and transforming protein that is related to Rho-specific exchange factors and yeast cell cycle regulators. The expression of this gene is elevated with the onset of DNA synthesis and remains elevated during G2 and M phases. In situ hybridization analysis showed that expression is at a high level in cells undergoing mitosis in regenerating liver. Thus, this protein is expressed in a cell cycle-dependent manner during liver regeneration, and is thought to have an important role in the regulation of cytokinesis. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)5.99154190
2protein localization to chromosome, centromeric region (GO:0071459)5.21399749
3mitotic metaphase plate congression (GO:0007080)5.15626776
4mitotic sister chromatid segregation (GO:0000070)5.10741620
5nuclear pore organization (GO:0006999)5.08339301
6mitotic chromosome condensation (GO:0007076)5.00741769
7nuclear pore complex assembly (GO:0051292)4.95231751
8sister chromatid segregation (GO:0000819)4.92701790
9DNA unwinding involved in DNA replication (GO:0006268)4.86304512
10kinetochore organization (GO:0051383)4.76289965
11attachment of spindle microtubules to kinetochore (GO:0008608)4.71647631
12metaphase plate congression (GO:0051310)4.61862192
13regulation of spindle organization (GO:0090224)4.57943121
14mitotic nuclear envelope disassembly (GO:0007077)4.54158208
15DNA replication-dependent nucleosome organization (GO:0034723)4.45900238
16DNA replication-dependent nucleosome assembly (GO:0006335)4.45900238
17regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.44014454
18chromatin remodeling at centromere (GO:0031055)4.42517738
19* regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.38549442
20CENP-A containing nucleosome assembly (GO:0034080)4.38053304
21establishment of integrated proviral latency (GO:0075713)4.34568205
22meiotic chromosome segregation (GO:0045132)4.31387877
23DNA replication initiation (GO:0006270)4.24205822
24membrane disassembly (GO:0030397)4.23795678
25nuclear envelope disassembly (GO:0051081)4.23795678
26DNA ligation (GO:0006266)4.22905656
27establishment of chromosome localization (GO:0051303)4.21043761
28DNA strand elongation involved in DNA replication (GO:0006271)4.10314651
29positive regulation of chromosome segregation (GO:0051984)4.08643557
30DNA replication-independent nucleosome organization (GO:0034724)4.07421296
31DNA replication-independent nucleosome assembly (GO:0006336)4.07421296
32regulation of mitotic spindle organization (GO:0060236)4.06555955
33kinetochore assembly (GO:0051382)4.03005149
34protein localization to chromosome (GO:0034502)3.93374295
35positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.89784582
36positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.89784582
37positive regulation of mitotic sister chromatid separation (GO:1901970)3.89784582
38DNA strand elongation (GO:0022616)3.89166775
39spindle checkpoint (GO:0031577)3.86454925
40histone exchange (GO:0043486)3.83695298
41DNA replication checkpoint (GO:0000076)3.83616582
42pore complex assembly (GO:0046931)3.82758178
43* regulation of chromosome segregation (GO:0051983)3.82615445
44mitotic sister chromatid cohesion (GO:0007064)3.78579173
45regulation of sister chromatid cohesion (GO:0007063)3.76501750
46telomere maintenance via semi-conservative replication (GO:0032201)3.73100826
47mitotic recombination (GO:0006312)3.70737612
48chromosome segregation (GO:0007059)3.69236132
49spindle assembly checkpoint (GO:0071173)3.67679697
50folic acid-containing compound biosynthetic process (GO:0009396)3.64913729
51negative regulation of chromosome segregation (GO:0051985)3.64169247
52regulation of DNA endoreduplication (GO:0032875)3.63505603
53regulation of mitotic metaphase/anaphase transition (GO:0030071)3.62870383
54regulation of centrosome cycle (GO:0046605)3.59537373
55negative regulation of mitotic sister chromatid separation (GO:2000816)3.58398151
56negative regulation of mitotic sister chromatid segregation (GO:0033048)3.58398151
57negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.58398151
58negative regulation of sister chromatid segregation (GO:0033046)3.58398151
59protein K6-linked ubiquitination (GO:0085020)3.57211559
60regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.55892992
61DNA geometric change (GO:0032392)3.55616638
62chromatin assembly or disassembly (GO:0006333)3.55609862
63nucleobase biosynthetic process (GO:0046112)3.55497190
64DNA duplex unwinding (GO:0032508)3.54874510
65mitotic spindle checkpoint (GO:0071174)3.54745106
66regulation of histone H3-K9 methylation (GO:0051570)3.53726491
67mitotic spindle assembly checkpoint (GO:0007094)3.53584771
68telomere maintenance via recombination (GO:0000722)3.52775858
69negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.49500123
70IMP biosynthetic process (GO:0006188)3.47751630
71regulation of sister chromatid segregation (GO:0033045)3.46710442
72regulation of mitotic sister chromatid separation (GO:0010965)3.46710442
73regulation of mitotic sister chromatid segregation (GO:0033047)3.46710442
74regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.46232766
75regulation of centrosome duplication (GO:0010824)3.45700341
76chromosome condensation (GO:0030261)3.45355046
77non-recombinational repair (GO:0000726)3.45061816
78double-strand break repair via nonhomologous end joining (GO:0006303)3.45061816
79determination of adult lifespan (GO:0008340)3.30065626
80spindle assembly involved in mitosis (GO:0090307)3.29125187
81nuclear envelope organization (GO:0006998)3.28294800
82purine nucleobase biosynthetic process (GO:0009113)3.26453097
83heterochromatin organization (GO:0070828)3.25394204
84somatic diversification of immune receptors via somatic mutation (GO:0002566)3.22993838
85somatic hypermutation of immunoglobulin genes (GO:0016446)3.22993838
86regulation of centriole replication (GO:0046599)3.22950408
87regulation of helicase activity (GO:0051095)3.21471680
88telomere maintenance via telomere lengthening (GO:0010833)3.20332553
89ATP-dependent chromatin remodeling (GO:0043044)3.19143777
90DNA conformation change (GO:0071103)3.19072462
91negative regulation of mitosis (GO:0045839)3.18669176
92protein complex localization (GO:0031503)3.17857596
93negative regulation of histone methylation (GO:0031061)3.15972549
94DNA topological change (GO:0006265)3.15853683
95microtubule depolymerization (GO:0007019)3.15618382
96establishment of viral latency (GO:0019043)3.15301931
97mitotic spindle organization (GO:0007052)3.14696305
98regulation of telomere maintenance via telomerase (GO:0032210)3.14667782
99formation of translation preinitiation complex (GO:0001731)3.13227598
100regulation of gene silencing by RNA (GO:0060966)3.10936096
101regulation of posttranscriptional gene silencing (GO:0060147)3.10936096
102regulation of gene silencing by miRNA (GO:0060964)3.10936096
103DNA packaging (GO:0006323)3.09221602
104IMP metabolic process (GO:0046040)3.07338396
105chromatin assembly (GO:0031497)3.06858977
106nucleotide-excision repair, DNA gap filling (GO:0006297)3.05972005
107ventricular cardiac muscle cell development (GO:0055015)3.03587953
108mitotic cytokinesis (GO:0000281)3.01410502
109histone-serine phosphorylation (GO:0035404)3.00167126
110ribosome assembly (GO:0042255)2.99413242
111mitotic G2/M transition checkpoint (GO:0044818)2.99370465
112mismatch repair (GO:0006298)2.98485365
113mitotic cell cycle (GO:0000278)2.97517587
114dosage compensation (GO:0007549)2.95933608
115anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.94617817
116microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.91189528
117regulation of spindle checkpoint (GO:0090231)2.89846212
118negative regulation of DNA repair (GO:0045738)2.86030450
119chromosome organization (GO:0051276)2.85131485
120negative regulation of cell division (GO:0051782)2.84723452

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* FOXM1_23109430_ChIP-Seq_U2OS_Human6.56809527
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.63833108
3* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.06560374
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.75581293
5AR_21909140_ChIP-Seq_LNCAP_Human2.87928369
6MYC_19079543_ChIP-ChIP_MESCs_Mouse2.85590288
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.83172308
8MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.78651910
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.77448391
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.58327856
11* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.48346487
12NELFA_20434984_ChIP-Seq_ESCs_Mouse2.35043913
13E2F1_21310950_ChIP-Seq_MCF-7_Human2.33832473
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.26230181
15* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.25454777
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.24256219
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.16947421
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.09509338
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.04078193
20XRN2_22483619_ChIP-Seq_HELA_Human2.02670361
21E2F7_22180533_ChIP-Seq_HELA_Human10.2959903
22ETS1_20019798_ChIP-Seq_JURKAT_Human1.89684390
23NANOG_18555785_ChIP-Seq_MESCs_Mouse1.88931728
24* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.86200785
25SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.79337390
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.77605776
27POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.73432285
28GABP_17652178_ChIP-ChIP_JURKAT_Human1.72990408
29VDR_23849224_ChIP-Seq_CD4+_Human1.70813562
30FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.68046506
31* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.66061826
32TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.65312590
33JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.65159473
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.63890090
35PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.62923548
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55388778
37POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.55108815
38* FOXP3_21729870_ChIP-Seq_TREG_Human1.53911860
39TTF2_22483619_ChIP-Seq_HELA_Human1.52955030
40* SALL1_21062744_ChIP-ChIP_HESCs_Human1.51604011
41DCP1A_22483619_ChIP-Seq_HELA_Human1.48650769
42ELK1_19687146_ChIP-ChIP_HELA_Human1.47553380
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46591479
44CIITA_25753668_ChIP-Seq_RAJI_Human1.44973262
45MYC_22102868_ChIP-Seq_BL_Human1.43250639
46* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.40037280
47ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39859656
48POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.39144832
49STAT3_1855785_ChIP-Seq_MESCs_Mouse1.38454512
50TP63_19390658_ChIP-ChIP_HaCaT_Human1.37531234
51GABP_19822575_ChIP-Seq_HepG2_Human1.37392175
52* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.33446843
53* KDM5A_27292631_Chip-Seq_BREAST_Human1.33125582
54THAP11_20581084_ChIP-Seq_MESCs_Mouse1.27709750
55KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.26994675
56KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.26994675
57KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.26994675
58ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.25344331
59KLF4_18555785_ChIP-Seq_MESCs_Mouse1.24943102
60ESR1_15608294_ChIP-ChIP_MCF-7_Human1.20812357
61HOXB4_20404135_ChIP-ChIP_EML_Mouse1.20639810
62ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.19718479
63PADI4_21655091_ChIP-ChIP_MCF-7_Human1.18708487
64NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.17993845
65CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17521992
66SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.17121629
67TCF3_18692474_ChIP-Seq_MEFs_Mouse1.16429422
68E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15733046
69RBPJ_22232070_ChIP-Seq_NCS_Mouse1.15283525
70FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.13291514
71* SOX17_20123909_ChIP-Seq_XEN_Mouse1.12842833
72HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.12212116
73TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.10402388
74NANOG_21062744_ChIP-ChIP_HESCs_Human1.09605056
75* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09509234
76ELF1_17652178_ChIP-ChIP_JURKAT_Human1.08283076
77* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.07751744
78NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.05773722
79EWS_26573619_Chip-Seq_HEK293_Human1.05754355
80SOX2_16153702_ChIP-ChIP_HESCs_Human1.05088252
81SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.03783592
82NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.03423688
83TFEB_21752829_ChIP-Seq_HELA_Human1.03233900
84E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.02765577
85HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.01609653
86* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.00202530
87NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.99844721
88TCF3_18692474_ChIP-Seq_MESCs_Mouse0.99561591
89POU5F1_16153702_ChIP-ChIP_HESCs_Human0.98257719
90ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.96808772
91CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.95908319
92DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.95110807
93* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.94361724
94CHD1_26751641_Chip-Seq_LNCaP_Human0.89750418
95CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89349162
96YY1_21170310_ChIP-Seq_MESCs_Mouse0.88805363
97SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.87883757
98* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.87869251
99ERG_20887958_ChIP-Seq_HPC-7_Mouse0.85741226
100* SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.85616862
101SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.84018266
102MYC_18940864_ChIP-ChIP_HL60_Human0.82366728
103* NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.80815574
104CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.80715284
105HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.80477855
106* FUS_26573619_Chip-Seq_HEK293_Human0.79092524
107NANOG_16153702_ChIP-ChIP_HESCs_Human0.79041846
108* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.79023222
109* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.78962690
110TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.76856564
111* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.76214418
112* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.74552375
113* SRF_21415370_ChIP-Seq_HL-1_Mouse0.74219442
114ZNF263_19887448_ChIP-Seq_K562_Human0.72173339
115* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.69298525
116HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.68933666
117* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.68668784
118DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.67129122
119FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.66652312
120PKCTHETA_26484144_Chip-Seq_BREAST_Human0.63281544

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.09937334
2MP0010094_abnormal_chromosome_stability4.83953893
3MP0003111_abnormal_nucleus_morphology4.64860877
4MP0004957_abnormal_blastocyst_morpholog4.18136532
5MP0003077_abnormal_cell_cycle4.04013245
6MP0008057_abnormal_DNA_replication3.82302120
7MP0010352_gastrointestinal_tract_polyps3.06181416
8MP0008058_abnormal_DNA_repair2.93858359
9MP0008007_abnormal_cellular_replicative2.70922324
10MP0010307_abnormal_tumor_latency2.56294308
11MP0008932_abnormal_embryonic_tissue2.52800550
12MP0003123_paternal_imprinting2.51451656
13MP0001730_embryonic_growth_arrest2.48328608
14MP0000350_abnormal_cell_proliferation2.42306595
15MP0003705_abnormal_hypodermis_morpholog2.09807391
16MP0008877_abnormal_DNA_methylation2.05478791
17MP0009697_abnormal_copulation1.99434138
18MP0001672_abnormal_embryogenesis/_devel1.93821120
19MP0005380_embryogenesis_phenotype1.93821120
20MP0001697_abnormal_embryo_size1.85903920
21MP0005076_abnormal_cell_differentiation1.81727708
22MP0002085_abnormal_embryonic_tissue1.77072112
23MP0002396_abnormal_hematopoietic_system1.75912487
24MP0003786_premature_aging1.75279191
25MP0002084_abnormal_developmental_patter1.74506030
26MP0003984_embryonic_growth_retardation1.71634454
27MP0002088_abnormal_embryonic_growth/wei1.68815311
28MP0004197_abnormal_fetal_growth/weight/1.67952623
29MP0003890_abnormal_embryonic-extraembry1.66648706
30MP0010030_abnormal_orbit_morphology1.66303941
31MP0002086_abnormal_extraembryonic_tissu1.63684037
32MP0003121_genomic_imprinting1.61575834
33* MP0002080_prenatal_lethality1.59964626
34MP0006292_abnormal_olfactory_placode1.49515715
35MP0000490_abnormal_crypts_of1.46688722
36MP0000537_abnormal_urethra_morphology1.44261361
37MP0003950_abnormal_plasma_membrane1.43010458
38MP0003718_maternal_effect1.39283919
39MP0003567_abnormal_fetal_cardiomyocyte1.38197186
40MP0009053_abnormal_anal_canal1.36600678
41MP0000313_abnormal_cell_death1.36421242
42MP0002210_abnormal_sex_determination1.30819916
43MP0002019_abnormal_tumor_incidence1.29631071
44MP0000566_synostosis1.29357041
45MP0001346_abnormal_lacrimal_gland1.28872243
46MP0004808_abnormal_hematopoietic_stem1.27531128
47MP0001293_anophthalmia1.26679016
48MP0000579_abnormal_nail_morphology1.17780778
49MP0003937_abnormal_limbs/digits/tail_de1.17421080
50MP0001145_abnormal_male_reproductive1.13715121
51MP0002234_abnormal_pharynx_morphology1.12062580
52MP0003566_abnormal_cell_adhesion1.08153370
53MP0003941_abnormal_skin_development1.05764203
54MP0002938_white_spotting1.05724439
55MP0002233_abnormal_nose_morphology1.05423002
56MP0000427_abnormal_hair_cycle1.05063605
57MP0004233_abnormal_muscle_weight1.04507857
58MP0001929_abnormal_gametogenesis1.03806701
59MP0000762_abnormal_tongue_morphology1.03302017
60MP0003119_abnormal_digestive_system1.03198850
61MP0004185_abnormal_adipocyte_glucose1.02028256
62MP0002009_preneoplasia1.01895246
63MP0000647_abnormal_sebaceous_gland0.99719208
64MP0002653_abnormal_ependyma_morphology0.99211654
65MP0003806_abnormal_nucleotide_metabolis0.97983699
66MP0005623_abnormal_meninges_morphology0.97944465
67MP0000653_abnormal_sex_gland0.97350859
68MP0003315_abnormal_perineum_morphology0.96179621
69MP0005023_abnormal_wound_healing0.95119861
70MP0002877_abnormal_melanocyte_morpholog0.94133116
71MP0004264_abnormal_extraembryonic_tissu0.92773896
72MP0002111_abnormal_tail_morphology0.91029372
73MP0001849_ear_inflammation0.90237168
74MP0009672_abnormal_birth_weight0.88145468
75MP0000703_abnormal_thymus_morphology0.87581714
76MP0009703_decreased_birth_body0.85995918
77MP0005248_abnormal_Harderian_gland0.85076441
78MP0002796_impaired_skin_barrier0.85056531
79MP0002092_abnormal_eye_morphology0.83991866
80MP0000733_abnormal_muscle_development0.82668040
81MP0001545_abnormal_hematopoietic_system0.82547988
82MP0005397_hematopoietic_system_phenotyp0.82547988
83MP0003943_abnormal_hepatobiliary_system0.82447282
84MP0001286_abnormal_eye_development0.81003728
85MP0001119_abnormal_female_reproductive0.80548436
86MP0005395_other_phenotype0.80241829
87MP0005621_abnormal_cell_physiology0.79555688
88MP0000428_abnormal_craniofacial_morphol0.79232341
89MP0010234_abnormal_vibrissa_follicle0.79054469
90MP0004133_heterotaxia0.78313577
91MP0006054_spinal_hemorrhage0.78074486
92MP0002697_abnormal_eye_size0.77413075
93MP0000432_abnormal_head_morphology0.77367145
94MP0002098_abnormal_vibrissa_morphology0.76880091
95MP0005384_cellular_phenotype0.76651293
96MP0000858_altered_metastatic_potential0.75794460
97MP0001915_intracranial_hemorrhage0.75131753
98MP0009278_abnormal_bone_marrow0.74649633
99MP0008789_abnormal_olfactory_epithelium0.74471997
100MP0003115_abnormal_respiratory_system0.73685614
101MP0001299_abnormal_eye_distance/0.73617740
102MP0004272_abnormal_basement_membrane0.73082990
103MP0003385_abnormal_body_wall0.71318649
104MP0006072_abnormal_retinal_apoptosis0.69721388
105MP0005408_hypopigmentation0.68449499
106MP0002925_abnormal_cardiovascular_devel0.68369459
107MP0003935_abnormal_craniofacial_develop0.67936294
108MP0005197_abnormal_uvea_morphology0.65548413
109MP0002060_abnormal_skin_morphology0.65209059
110MP0003755_abnormal_palate_morphology0.65044576
111MP0003942_abnormal_urinary_system0.64994253
112MP0005391_vision/eye_phenotype0.64366438
113MP0002722_abnormal_immune_system0.64164369
114MP0000477_abnormal_intestine_morphology0.63768308
115MP0003283_abnormal_digestive_organ0.61993034
116MP0005389_reproductive_system_phenotype0.61765069
117MP0003861_abnormal_nervous_system0.61759653
118MP0002398_abnormal_bone_marrow0.61488936
119MP0009333_abnormal_splenocyte_physiolog0.59550271
120MP0002160_abnormal_reproductive_system0.58441113
121MP0003448_altered_tumor_morphology0.57995165
122MP0000383_abnormal_hair_follicle0.57956853
123MP0002282_abnormal_trachea_morphology0.57899575
124MP0000358_abnormal_cell_content/0.57552916
125MP0003699_abnormal_female_reproductive0.55399066
126MP0010678_abnormal_skin_adnexa0.55103457
127MP0000627_abnormal_mammary_gland0.54840710
128MP0003698_abnormal_male_reproductive0.53080415
129MP0005266_abnormal_metabolism0.53033181
130MP0005501_abnormal_skin_physiology0.53017499
131MP0002161_abnormal_fertility/fecundity0.51659696

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.67548988
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.46304201
3Colon cancer (HP:0003003)3.86793072
4Ependymoma (HP:0002888)3.86137667
5Birth length less than 3rd percentile (HP:0003561)3.67032985
6Abnormality of chromosome stability (HP:0003220)3.56533745
7Medulloblastoma (HP:0002885)3.40504136
8Selective tooth agenesis (HP:0001592)3.39749997
9Impulsivity (HP:0100710)3.26127179
10Meckel diverticulum (HP:0002245)3.25788180
11Abnormality of the labia minora (HP:0012880)3.23322679
12Breast hypoplasia (HP:0003187)3.18221833
13Reticulocytopenia (HP:0001896)3.16622086
14Aplasia/Hypoplasia of the uvula (HP:0010293)3.16080448
15Rhabdomyosarcoma (HP:0002859)3.12436883
16Abnormality of the preputium (HP:0100587)3.10921533
17Small intestinal stenosis (HP:0012848)3.08839820
18Duodenal stenosis (HP:0100867)3.08839820
19Abnormality of the ileum (HP:0001549)3.07006031
20Patellar aplasia (HP:0006443)3.04536584
21Cortical dysplasia (HP:0002539)3.00041345
22Absent radius (HP:0003974)2.99997263
23Agnosia (HP:0010524)2.94703615
24Increased nuchal translucency (HP:0010880)2.87603579
25Astrocytoma (HP:0009592)2.86899072
26Abnormality of the astrocytes (HP:0100707)2.86899072
27Volvulus (HP:0002580)2.83267868
28Aplasia/Hypoplasia of the patella (HP:0006498)2.82359643
29Aplasia involving forearm bones (HP:0009822)2.79661652
30Absent forearm bone (HP:0003953)2.79661652
31Ectopic kidney (HP:0000086)2.74858053
32Myelodysplasia (HP:0002863)2.65400254
33Abnormal lung lobation (HP:0002101)2.64239674
34Oral leukoplakia (HP:0002745)2.61045709
35Abnormality of the duodenum (HP:0002246)2.58827804
36Deviation of the thumb (HP:0009603)2.58662492
37Proximal placement of thumb (HP:0009623)2.57224731
38Glioma (HP:0009733)2.51617131
39Sloping forehead (HP:0000340)2.51428454
40Carpal bone hypoplasia (HP:0001498)2.48110425
41Supernumerary spleens (HP:0009799)2.47179424
42Neoplasm of the pancreas (HP:0002894)2.45008785
43Absent thumb (HP:0009777)2.43260470
44Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.39959902
45Short 4th metacarpal (HP:0010044)2.39959902
46Neoplasm of striated muscle (HP:0009728)2.38223621
47Biliary tract neoplasm (HP:0100574)2.38083829
48Neoplasm of the oral cavity (HP:0100649)2.37837793
4911 pairs of ribs (HP:0000878)2.36644052
50Facial hemangioma (HP:0000329)2.35057627
51Degeneration of anterior horn cells (HP:0002398)2.34738975
52Abnormality of the anterior horn cell (HP:0006802)2.34738975
53Missing ribs (HP:0000921)2.33943082
54Cafe-au-lait spot (HP:0000957)2.31457095
55Nephroblastoma (Wilms tumor) (HP:0002667)2.31159036
56Abnormality of the carotid arteries (HP:0005344)2.26689197
57Duplicated collecting system (HP:0000081)2.24835743
58Neoplasm of the colon (HP:0100273)2.24067584
59Tracheoesophageal fistula (HP:0002575)2.22844418
60Basal cell carcinoma (HP:0002671)2.21539050
61Abnormal number of incisors (HP:0011064)2.21189797
62Malignant gastrointestinal tract tumors (HP:0006749)2.19036735
63Gastrointestinal carcinoma (HP:0002672)2.19036735
64Aplasia/Hypoplasia of the sternum (HP:0006714)2.18498624
65Atresia of the external auditory canal (HP:0000413)2.17624356
66Deep philtrum (HP:0002002)2.15735963
67Embryonal renal neoplasm (HP:0011794)2.14765413
68Horseshoe kidney (HP:0000085)2.13353922
69Aplasia/hypoplasia of the humerus (HP:0006507)2.11772662
70Bone marrow hypocellularity (HP:0005528)2.10370374
71Squamous cell carcinoma (HP:0002860)2.07864480
72Aplasia/Hypoplasia of the sacrum (HP:0008517)2.06325451
73Short thumb (HP:0009778)2.05540240
74Embryonal neoplasm (HP:0002898)2.04741983
75High pitched voice (HP:0001620)2.02079238
76Microglossia (HP:0000171)2.01579916
77Overlapping toe (HP:0001845)1.99126177
78Ovarian neoplasm (HP:0100615)1.99103036
79Rough bone trabeculation (HP:0100670)1.97934246
80Abnormality of the calcaneus (HP:0008364)1.93711425
81Short humerus (HP:0005792)1.92538552
82Abnormality of chromosome segregation (HP:0002916)1.91949503
83Clubbing of toes (HP:0100760)1.91835875
84Duplication of thumb phalanx (HP:0009942)1.91725482
85Abnormality of the renal collecting system (HP:0004742)1.91708568
86Arteriovenous malformation (HP:0100026)1.90437756
87Prominent nose (HP:0000448)1.90105220
88Sandal gap (HP:0001852)1.89115059
89Esophageal atresia (HP:0002032)1.88707745
90Abnormality of abdominal situs (HP:0011620)1.86482465
91Abdominal situs inversus (HP:0003363)1.86482465
92Breast carcinoma (HP:0003002)1.86088972
93Abnormal umbilical cord blood vessels (HP:0011403)1.84959929
94Single umbilical artery (HP:0001195)1.84959929
95Abnormality of the fetal cardiovascular system (HP:0010948)1.84959929
96Triphalangeal thumb (HP:0001199)1.84699480
97Abnormality of the umbilical cord (HP:0010881)1.83344678
98Amaurosis fugax (HP:0100576)1.82188919
99Hypoplastic pelvis (HP:0008839)1.80962460
100Hypoplasia of the capital femoral epiphysis (HP:0003090)1.79338688
101Ankle contracture (HP:0006466)1.79313461
102Aplastic anemia (HP:0001915)1.78893540
103Intestinal polyp (HP:0005266)1.77021104
104Intestinal polyposis (HP:0200008)1.76513904
105Choanal atresia (HP:0000453)1.75871369
106Skull defect (HP:0001362)1.72870235
107Premature graying of hair (HP:0002216)1.72298700
108Abnormality of the proximal phalanges of the hand (HP:0009834)1.72128113
109Abnormality of the septum pellucidum (HP:0007375)1.71789346
110Trismus (HP:0000211)1.70314583
111Double outlet right ventricle (HP:0001719)1.69932540
112Congenital malformation of the right heart (HP:0011723)1.69932540
113Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.69696586
114Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.69242259
115Uterine neoplasm (HP:0010784)1.68571442
116Cutaneous melanoma (HP:0012056)1.67722342
117High anterior hairline (HP:0009890)1.67648703
118Insidious onset (HP:0003587)1.65788074
119Termporal pattern (HP:0011008)1.65788074
120Abnormality of glycolysis (HP:0004366)1.59189797
121Facial cleft (HP:0002006)1.58777712
122Multiple enchondromatosis (HP:0005701)1.56886320
123Oligodactyly (hands) (HP:0001180)1.56682646
124Abnormal auditory evoked potentials (HP:0006958)1.54356935
125Uterine leiomyosarcoma (HP:0002891)1.53743453
126Leiomyosarcoma (HP:0100243)1.53743453
127Capillary hemangiomas (HP:0005306)1.51273783
128Absent septum pellucidum (HP:0001331)1.50156632
129Partial agenesis of the corpus callosum (HP:0001338)1.50064636
130Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.49363023
131Absent epiphyses (HP:0010577)1.49363023
132Dandy-Walker malformation (HP:0001305)1.49213884
133Increased serum pyruvate (HP:0003542)1.46863666
134Overriding aorta (HP:0002623)1.44249271
135Oligodactyly (HP:0012165)1.43940492
136Abnormality of methionine metabolism (HP:0010901)1.43731405

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.59551935
2BUB14.37272220
3WEE14.21529793
4NEK23.42501896
5TTK3.13236753
6CDK122.84180948
7NEK12.79457989
8BRSK22.54592343
9* PLK12.24439722
10SRPK12.23887862
11MST1R2.09805327
12AURKB2.00785848
13EIF2AK11.96321994
14EPHA21.90258183
15PLK31.89721971
16PLK41.89247344
17EEF2K1.86747067
18RPS6KB21.83480080
19STK101.75266607
20TSSK61.74199929
21ACVR1B1.71722535
22MKNK11.70757070
23CHEK21.70383631
24PASK1.67449113
25TAF11.67089704
26ATR1.67051646
27CDK71.63141056
28BRSK11.60522967
29TRIM281.54882981
30CDK41.54776397
31MAP3K81.53147039
32VRK21.50601344
33STK41.47114614
34MELK1.46024145
35CHEK11.41858156
36CCNB11.41468590
37TLK11.40683642
38RPS6KA41.37407620
39SCYL21.35218106
40FLT31.28042212
41DYRK31.26334778
42AURKA1.25835726
43VRK11.25683963
44MKNK21.22144373
45PKN21.16373048
46CDK61.14872970
47TESK21.13887402
48BRD41.10636862
49STK31.10583250
50PAK41.09134447
51LATS11.08270464
52ATM1.07326713
53ZAK1.05233602
54ERBB41.01009626
55CDK20.93482069
56MAP3K100.93378984
57TGFBR10.92615115
58NUAK10.92323410
59EIF2AK30.84530453
60LRRK20.79578072
61PIM10.78504034
62STK390.78182806
63ALK0.77462074
64* CDK10.76972538
65BCR0.75095233
66PBK0.66960292
67SMG10.66943941
68NME20.65139299
69STK38L0.63429937
70PAK10.62271541
71PNCK0.62013843
72MTOR0.60759534
73LATS20.59012906
74TTN0.58520247
75TESK10.54242945
76BRAF0.51591456
77BMPR1B0.50241415
78MET0.48592051
79CSNK2A20.48571880
80EIF2AK20.47934709
81MAP3K90.46777480
82CSNK2A10.45941649
83MARK30.45842685
84RPS6KA50.45832760
85WNK40.45521297
86CLK10.44672666
87AKT20.42947887
88PRKDC0.42885885
89PTK20.42881776
90CSNK1D0.40590922
91TNIK0.39784144
92PLK20.39647064
93PAK20.36022514
94STK240.35753305
95WNK30.35267134
96CDK180.34371575
97NEK60.34229014
98CSNK1E0.34147796
99AKT30.33791722
100MAPK140.31688053
101ICK0.31125882
102MST40.30589588
103CDK90.29516174
104NEK90.29178205
105PTK60.28745454
106STK160.28569920
107FGFR10.27835538
108CAMK1G0.27157449
109YES10.26779929
110PDGFRA0.26682335
111ERBB30.26670148
112PDK40.26033025
113PDK30.26033025
114AKT10.24966897
115CDK80.24759836
116MAPKAPK30.24395956
117MAPK10.23940667
118CDK11A0.23884325
119CDK30.23708319
120SIK30.23434911
121GSK3B0.22173035
122KSR10.17900142
123DYRK1B0.16677448
124RAF10.16241767
125CDK150.14853294

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.74956361
2Mismatch repair_Homo sapiens_hsa034304.37260395
3Cell cycle_Homo sapiens_hsa041103.54615375
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.43839210
5RNA transport_Homo sapiens_hsa030133.30513250
6Homologous recombination_Homo sapiens_hsa034403.15250938
7Spliceosome_Homo sapiens_hsa030403.13525255
8Base excision repair_Homo sapiens_hsa034103.03459797
9One carbon pool by folate_Homo sapiens_hsa006702.91133622
10Nucleotide excision repair_Homo sapiens_hsa034202.76012197
11Fanconi anemia pathway_Homo sapiens_hsa034602.70012784
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.51451777
13Non-homologous end-joining_Homo sapiens_hsa034502.37516600
14RNA polymerase_Homo sapiens_hsa030202.27795576
15p53 signaling pathway_Homo sapiens_hsa041152.02783234
16Ribosome_Homo sapiens_hsa030102.02638576
17mRNA surveillance pathway_Homo sapiens_hsa030152.01307060
18RNA degradation_Homo sapiens_hsa030181.97299540
19Systemic lupus erythematosus_Homo sapiens_hsa053221.96399197
20Pyrimidine metabolism_Homo sapiens_hsa002401.88738315
21Proteasome_Homo sapiens_hsa030501.82266321
22Basal transcription factors_Homo sapiens_hsa030221.77313803
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.43879035
24Oocyte meiosis_Homo sapiens_hsa041141.40556047
25Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.39890246
26Viral carcinogenesis_Homo sapiens_hsa052031.38394084
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.37694200
28Protein export_Homo sapiens_hsa030601.32143506
29MicroRNAs in cancer_Homo sapiens_hsa052061.22346541
30Pyruvate metabolism_Homo sapiens_hsa006201.20579243
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.18877233
32Steroid biosynthesis_Homo sapiens_hsa001001.15407570
33Epstein-Barr virus infection_Homo sapiens_hsa051691.12378069
34Small cell lung cancer_Homo sapiens_hsa052221.01275668
35Selenocompound metabolism_Homo sapiens_hsa004501.00442558
36HTLV-I infection_Homo sapiens_hsa051660.99428762
37Purine metabolism_Homo sapiens_hsa002300.94462012
38Antigen processing and presentation_Homo sapiens_hsa046120.93681895
39Propanoate metabolism_Homo sapiens_hsa006400.93350829
40Biosynthesis of amino acids_Homo sapiens_hsa012300.90142163
41Herpes simplex infection_Homo sapiens_hsa051680.89782155
42Vitamin B6 metabolism_Homo sapiens_hsa007500.89464164
43Hippo signaling pathway_Homo sapiens_hsa043900.86125396
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.83288575
45Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.83197233
46Alcoholism_Homo sapiens_hsa050340.83140071
47Thyroid cancer_Homo sapiens_hsa052160.81436068
48TGF-beta signaling pathway_Homo sapiens_hsa043500.77890535
49Colorectal cancer_Homo sapiens_hsa052100.77726620
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.76153741
51Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73364503
52Adherens junction_Homo sapiens_hsa045200.73041995
53Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72648014
54Chronic myeloid leukemia_Homo sapiens_hsa052200.71855336
55Basal cell carcinoma_Homo sapiens_hsa052170.71836973
56Pentose phosphate pathway_Homo sapiens_hsa000300.70563907
57Cysteine and methionine metabolism_Homo sapiens_hsa002700.61986482
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60972433
59Fatty acid elongation_Homo sapiens_hsa000620.60832132
60Bladder cancer_Homo sapiens_hsa052190.59736825
61Apoptosis_Homo sapiens_hsa042100.52868132
62Notch signaling pathway_Homo sapiens_hsa043300.51332506
63Legionellosis_Homo sapiens_hsa051340.50084853
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48876269
65Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.48838571
66Hepatitis B_Homo sapiens_hsa051610.48494799
67Pathways in cancer_Homo sapiens_hsa052000.48035918
68Pancreatic cancer_Homo sapiens_hsa052120.47835037
69Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.46720332
70Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.46038185
71Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.45224063
72Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.44271943
73Central carbon metabolism in cancer_Homo sapiens_hsa052300.43787913
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42334460
75mTOR signaling pathway_Homo sapiens_hsa041500.42058183
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.41725777
77Cyanoamino acid metabolism_Homo sapiens_hsa004600.40868860
78Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.40735447
79Melanoma_Homo sapiens_hsa052180.40473035
80Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.40208837
81Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.39428647
82Viral myocarditis_Homo sapiens_hsa054160.38701964
83Prostate cancer_Homo sapiens_hsa052150.38622442
84Tight junction_Homo sapiens_hsa045300.37766877
85Hedgehog signaling pathway_Homo sapiens_hsa043400.36955985
86Lysine degradation_Homo sapiens_hsa003100.36449362
87Proteoglycans in cancer_Homo sapiens_hsa052050.35208731
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.34091046
89Huntingtons disease_Homo sapiens_hsa050160.33629513
90Non-small cell lung cancer_Homo sapiens_hsa052230.32310303
91Folate biosynthesis_Homo sapiens_hsa007900.32147008
92Carbon metabolism_Homo sapiens_hsa012000.31619927
93FoxO signaling pathway_Homo sapiens_hsa040680.30864478
94Metabolic pathways_Homo sapiens_hsa011000.29946324
95Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.29658461
96Endometrial cancer_Homo sapiens_hsa052130.29113103
97NF-kappa B signaling pathway_Homo sapiens_hsa040640.29089844
98HIF-1 signaling pathway_Homo sapiens_hsa040660.28872595
99Primary immunodeficiency_Homo sapiens_hsa053400.28699671
100Glutathione metabolism_Homo sapiens_hsa004800.27248056
101Arginine and proline metabolism_Homo sapiens_hsa003300.27199549
102Sulfur metabolism_Homo sapiens_hsa009200.26372810
103Influenza A_Homo sapiens_hsa051640.25791873
104Leukocyte transendothelial migration_Homo sapiens_hsa046700.25456109
105Shigellosis_Homo sapiens_hsa051310.25311869
106Sulfur relay system_Homo sapiens_hsa041220.23506474
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.23269000
108NOD-like receptor signaling pathway_Homo sapiens_hsa046210.23267792
109Wnt signaling pathway_Homo sapiens_hsa043100.23256531
110Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.23071373
111Measles_Homo sapiens_hsa051620.22924636
112Asthma_Homo sapiens_hsa053100.21835449
113Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.20484382
114Regulation of actin cytoskeleton_Homo sapiens_hsa048100.20155792
115ECM-receptor interaction_Homo sapiens_hsa045120.20070725
116Arginine biosynthesis_Homo sapiens_hsa002200.19716662
117PI3K-Akt signaling pathway_Homo sapiens_hsa041510.19601780
118Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.19245131
119Fatty acid biosynthesis_Homo sapiens_hsa000610.19180296
120N-Glycan biosynthesis_Homo sapiens_hsa005100.18612068
121Fatty acid metabolism_Homo sapiens_hsa012120.18328455
122Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.17640305
123Galactose metabolism_Homo sapiens_hsa000520.16968604
124Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.16865952
125Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.16318147
126Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.16080911
127Acute myeloid leukemia_Homo sapiens_hsa052210.15750623
128Focal adhesion_Homo sapiens_hsa045100.13188019
1292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.12070531
130Renin-angiotensin system_Homo sapiens_hsa046140.10853135
131Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.10633476

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