EDA2R

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a type III transmembrane protein of the TNFR (tumor necrosis factor receptor) superfamily, and contains cysteine-rich repeats and a single transmembrane domain. This protein binds to the EDA-A2 isoform of ectodysplasin, which plays an important role in maintenance of hair and teeth. Alternatively spliced transcript variants encodes distinct protein isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of posttranscriptional gene silencing (GO:0060147)4.92394307
2regulation of gene silencing by miRNA (GO:0060964)4.92394307
3regulation of gene silencing by RNA (GO:0060966)4.92394307
4nuclear pore organization (GO:0006999)4.88713928
5nuclear pore complex assembly (GO:0051292)4.82139321
6regulation of mitotic spindle organization (GO:0060236)4.52003753
7paraxial mesoderm development (GO:0048339)4.41576434
8positive regulation of SMAD protein import into nucleus (GO:0060391)4.10126411
9regulation of spindle organization (GO:0090224)3.90566206
10protein heterotrimerization (GO:0070208)3.90109965
11regulation of SMAD protein import into nucleus (GO:0060390)3.87474129
12DNA replication-dependent nucleosome assembly (GO:0006335)3.82251720
13DNA replication-dependent nucleosome organization (GO:0034723)3.82251720
14maturation of SSU-rRNA (GO:0030490)3.80371438
15mesenchymal-epithelial cell signaling (GO:0060638)3.79850175
16bone trabecula formation (GO:0060346)3.59411256
17mitotic nuclear envelope disassembly (GO:0007077)3.57636432
18polarized epithelial cell differentiation (GO:0030859)3.55004482
19pore complex assembly (GO:0046931)3.52328960
20regulation of helicase activity (GO:0051095)3.50945262
21IMP biosynthetic process (GO:0006188)3.49532793
22regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.49292328
23folic acid-containing compound biosynthetic process (GO:0009396)3.48265709
24regulation of hippo signaling (GO:0035330)3.44783575
25establishment of apical/basal cell polarity (GO:0035089)3.44180490
26plasma membrane repair (GO:0001778)3.44037033
27heterochromatin organization (GO:0070828)3.43231339
28nuclear envelope disassembly (GO:0051081)3.43207892
29membrane disassembly (GO:0030397)3.43207892
30negative regulation of axon extension involved in axon guidance (GO:0048843)3.39167531
31hippo signaling (GO:0035329)3.33143879
32DNA unwinding involved in DNA replication (GO:0006268)3.32970846
33ribosome assembly (GO:0042255)3.31151692
34regulation of centrosome cycle (GO:0046605)3.27428034
35regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.26449659
36protein localization to kinetochore (GO:0034501)3.25700981
37positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.23610786
38positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.23610786
39positive regulation of mitotic sister chromatid separation (GO:1901970)3.23610786
40mitotic metaphase plate congression (GO:0007080)3.21814967
41cell adhesion mediated by integrin (GO:0033627)3.20043937
42IMP metabolic process (GO:0046040)3.16864533
43cell migration involved in heart development (GO:0060973)3.16162775
44regulation of centrosome duplication (GO:0010824)3.15091083
45formation of translation preinitiation complex (GO:0001731)3.14817438
46kidney mesenchyme development (GO:0072074)3.12942904
47anterior/posterior axis specification, embryo (GO:0008595)3.11609188
48regulation of translational fidelity (GO:0006450)3.10335771
49cell migration involved in sprouting angiogenesis (GO:0002042)3.09023669
50COPII vesicle coating (GO:0048208)3.08874240
51neuron projection extension involved in neuron projection guidance (GO:1902284)3.06822640
52axon extension involved in axon guidance (GO:0048846)3.06822640
53blood vessel maturation (GO:0001955)3.04545694
54L-serine metabolic process (GO:0006563)3.02597817
55extracellular matrix assembly (GO:0085029)3.02324155
56metanephric mesenchyme development (GO:0072075)3.00603276
57chondrocyte proliferation (GO:0035988)3.00192977
58glomerular basement membrane development (GO:0032836)2.97383900
59negative regulation of DNA repair (GO:0045738)2.96444174
60positive regulation of chromosome segregation (GO:0051984)2.95873138
61establishment or maintenance of monopolar cell polarity (GO:0061339)2.92659109
62establishment of monopolar cell polarity (GO:0061162)2.92659109
63negative regulation of axon guidance (GO:1902668)2.91682529
64sister chromatid segregation (GO:0000819)2.91106310
65endodermal cell differentiation (GO:0035987)2.90501366
66negative chemotaxis (GO:0050919)2.89838181
67regulation of sister chromatid cohesion (GO:0007063)2.89121612
68embryonic process involved in female pregnancy (GO:0060136)2.88404397
69response to UV-C (GO:0010225)2.87842064
70sequestering of extracellular ligand from receptor (GO:0035581)2.86671795
71nodal signaling pathway (GO:0038092)2.86581579
72chromatin assembly (GO:0031497)2.86521008
73cellular response to vitamin (GO:0071295)2.85593461
74epithelial cell-cell adhesion (GO:0090136)2.85226852
75mitotic G2 DNA damage checkpoint (GO:0007095)2.83854914
76regulation of non-canonical Wnt signaling pathway (GO:2000050)2.83691662
77mitotic G2/M transition checkpoint (GO:0044818)2.81778702
78mitotic sister chromatid segregation (GO:0000070)2.79484493
79regulation of histone H3-K9 methylation (GO:0051570)2.78601125
80DNA duplex unwinding (GO:0032508)2.78374874
81DNA geometric change (GO:0032392)2.76487043
82pre-miRNA processing (GO:0031054)2.75099726
83notochord development (GO:0030903)2.73405518
84NLS-bearing protein import into nucleus (GO:0006607)2.73064945
85syncytium formation (GO:0006949)2.72940534
86metaphase plate congression (GO:0051310)2.71711658
87actin-myosin filament sliding (GO:0033275)2.70939354
88muscle filament sliding (GO:0030049)2.70939354
89type B pancreatic cell proliferation (GO:0044342)2.70626489
90negative regulation of protein localization to cell surface (GO:2000009)2.69654938
91nucleobase biosynthetic process (GO:0046112)2.69503642
92chaperone-mediated protein complex assembly (GO:0051131)2.69379507
93ganglion development (GO:0061548)2.69340941
94outer ear morphogenesis (GO:0042473)2.68561288
95convergent extension (GO:0060026)2.68200385
96nuclear envelope organization (GO:0006998)2.67830876
97regulation of axon extension involved in axon guidance (GO:0048841)2.67059784
98regulation of centriole replication (GO:0046599)2.66631539
99pyrimidine dimer repair (GO:0006290)2.66431277
100DNA replication initiation (GO:0006270)2.65881639
101negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.65781552
102negative regulation of histone methylation (GO:0031061)2.65751862
103cellular protein complex localization (GO:0034629)2.64542159
104positive regulation of endothelial cell apoptotic process (GO:2000353)2.64212495
105heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.63667932
106histone H2A monoubiquitination (GO:0035518)2.63510096
107regulation of plasminogen activation (GO:0010755)2.62335468
108pericardium development (GO:0060039)2.62248062
109dermatan sulfate biosynthetic process (GO:0030208)2.61696938
110regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.60950055
111skin morphogenesis (GO:0043589)2.60634509
112ER overload response (GO:0006983)2.60605155
113negative regulation of smooth muscle cell migration (GO:0014912)2.60551549
114mitotic G1 DNA damage checkpoint (GO:0031571)2.59862625
115apoptotic process involved in morphogenesis (GO:0060561)2.59804207
116mitotic chromosome condensation (GO:0007076)2.59638286
117embryonic camera-type eye development (GO:0031076)2.59562033
118ventricular cardiac muscle cell development (GO:0055015)2.59450247
119mitotic DNA integrity checkpoint (GO:0044774)2.59162783
120organ induction (GO:0001759)2.59047083
121Golgi transport vesicle coating (GO:0048200)2.58997792
122COPI coating of Golgi vesicle (GO:0048205)2.58997792
123collagen fibril organization (GO:0030199)2.58817836
124chondrocyte development (GO:0002063)2.57380753
125lung-associated mesenchyme development (GO:0060484)2.56218619
126response to redox state (GO:0051775)2.56195770
127regulation of translational termination (GO:0006449)2.56019738
128regulation of gene silencing (GO:0060968)2.55623258
129mitotic sister chromatid cohesion (GO:0007064)2.54722986
130chromatin remodeling at centromere (GO:0031055)2.54704723
131protein localization to chromosome, centromeric region (GO:0071459)2.54501830
132determination of adult lifespan (GO:0008340)2.53955268
133endocardial cushion development (GO:0003197)2.53806265
134regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.53397568
135craniofacial suture morphogenesis (GO:0097094)2.53323225
136wound healing, spreading of epidermal cells (GO:0035313)2.53070586
137negative regulation of chondrocyte differentiation (GO:0032331)2.52439683
138regulation of telomere maintenance via telomerase (GO:0032210)2.52418585
139dermatan sulfate metabolic process (GO:0030205)2.52056098
140adherens junction assembly (GO:0034333)2.50606650
141negative regulation of osteoblast proliferation (GO:0033689)2.48551934
142peptidyl-proline hydroxylation (GO:0019511)2.47505351
143G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.46901846
144spindle assembly involved in mitosis (GO:0090307)2.45950237
145regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.45484493
146basement membrane organization (GO:0071711)2.45450886
147planar cell polarity pathway involved in neural tube closure (GO:0090179)2.45299588
148protein K6-linked ubiquitination (GO:0085020)2.44963584
149regulation of axon guidance (GO:1902667)2.44817459
150positive regulation of male gonad development (GO:2000020)2.44573909
151muscle cell fate commitment (GO:0042693)2.44426225
152mitotic DNA damage checkpoint (GO:0044773)2.44035831
153regulation of RNA export from nucleus (GO:0046831)2.43340008
154positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.43321303
155collagen metabolic process (GO:0032963)2.42615277
156regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.42484256
157positive regulation of smoothened signaling pathway (GO:0045880)2.40267508
158establishment of tissue polarity (GO:0007164)2.39983940
159establishment of planar polarity (GO:0001736)2.39983940
160regulation of cardioblast differentiation (GO:0051890)2.39274914
161lysine metabolic process (GO:0006553)2.37178546
162lysine catabolic process (GO:0006554)2.37178546
163regulation of organ formation (GO:0003156)2.36533924
164regulation of chondrocyte differentiation (GO:0032330)2.36349366
165platelet dense granule organization (GO:0060155)2.36174021
166regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.36136492
167extracellular fibril organization (GO:0043206)2.36110448
168collagen catabolic process (GO:0030574)2.34956499
169negative regulation of cartilage development (GO:0061037)2.31388085
170negative regulation of stem cell proliferation (GO:2000647)2.30406165
171cellular response to vitamin D (GO:0071305)2.29261697
172vascular smooth muscle contraction (GO:0014829)2.28581539
173substrate adhesion-dependent cell spreading (GO:0034446)2.27450512
174cochlea morphogenesis (GO:0090103)2.26054230
175positive regulation of macrophage activation (GO:0043032)2.25925670
176ventricular septum development (GO:0003281)2.25894463
177Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.25306882
178substrate-dependent cell migration (GO:0006929)2.24835099
179endothelial cell morphogenesis (GO:0001886)2.24664889
180regulation of establishment of planar polarity (GO:0090175)2.24462450
181mitochondrial DNA metabolic process (GO:0032042)2.24445613
182mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.24317449
183lymphangiogenesis (GO:0001946)2.23351754
184retina vasculature morphogenesis in camera-type eye (GO:0061299)2.23082190
185positive regulation of cardiac muscle cell proliferation (GO:0060045)2.23063497
186mesodermal cell differentiation (GO:0048333)2.21268130
187multicellular organismal macromolecule metabolic process (GO:0044259)2.20827147
188response to hyperoxia (GO:0055093)2.19813746
189response to increased oxygen levels (GO:0036296)2.19813746

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.70610097
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.06249690
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.98785661
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.55902621
5* MYC_18555785_ChIP-Seq_MESCs_Mouse3.55880147
6SALL1_21062744_ChIP-ChIP_HESCs_Human3.08218403
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.02212599
8KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.02212599
9KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.02212599
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.97210283
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.90089929
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.84186683
13POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.84087370
14NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.83276996
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.80272953
16* TP53_18474530_ChIP-ChIP_U2OS_Human2.66063007
17SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.64508422
18* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.59892886
19TP53_16413492_ChIP-PET_HCT116_Human2.53796973
20TRIM28_21343339_ChIP-Seq_HEK293_Human2.49173099
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.42695991
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.39476533
23TCF3_18692474_ChIP-Seq_MEFs_Mouse2.39008800
24CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.30725008
25ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.28643634
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.26857674
27NELFA_20434984_ChIP-Seq_ESCs_Mouse2.25531277
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.22745447
29* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.21132893
30ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.17292186
31SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.16313542
32SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.13729610
33RBPJ_22232070_ChIP-Seq_NCS_Mouse2.12909275
34STAT3_1855785_ChIP-Seq_MESCs_Mouse2.12392613
35NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.11092197
36EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.09594508
37KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.05004740
38SOX2_18555785_ChIP-Seq_MESCs_Mouse2.04557582
39GBX2_23144817_ChIP-Seq_PC3_Human2.02991448
40ESR1_15608294_ChIP-ChIP_MCF-7_Human2.02052479
41SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.00154844
42TCF3_18692474_ChIP-Seq_MESCs_Mouse1.95260065
43AR_21909140_ChIP-Seq_LNCAP_Human1.91836693
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.89646218
45TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.89177478
46* CJUN_26792858_Chip-Seq_BT549_Human1.84776907
47NANOG_18555785_ChIP-Seq_MESCs_Mouse1.82837313
48RARG_19884340_ChIP-ChIP_MEFs_Mouse1.82591710
49ZFP57_27257070_Chip-Seq_ESCs_Mouse1.82507285
50HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.79685169
51NRF2_20460467_ChIP-Seq_MEFs_Mouse1.77968390
52NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.77968390
53ZNF274_21170338_ChIP-Seq_K562_Hela1.75568282
54POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.73321594
55EP300_21415370_ChIP-Seq_HL-1_Mouse1.72473120
56HIF1A_21447827_ChIP-Seq_MCF-7_Human1.64138481
57PCGF2_27294783_Chip-Seq_ESCs_Mouse1.62759957
58* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.62155307
59EWS_26573619_Chip-Seq_HEK293_Human1.55959423
60CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.55712386
61FLI1_27457419_Chip-Seq_LIVER_Mouse1.55418668
62FUS_26573619_Chip-Seq_HEK293_Human1.53146350
63ZNF263_19887448_ChIP-Seq_K562_Human1.53066253
64CLOCK_20551151_ChIP-Seq_293T_Human1.51008686
65KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.50912983
66* PIAS1_25552417_ChIP-Seq_VCAP_Human1.50790697
67XRN2_22483619_ChIP-Seq_HELA_Human1.50430561
68E2F1_21310950_ChIP-Seq_MCF-7_Human1.49150190
69SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.48080574
70TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.47787210
71E2F1_18555785_ChIP-Seq_MESCs_Mouse1.47554435
72SMAD_19615063_ChIP-ChIP_OVARY_Human1.47038851
73P300_19829295_ChIP-Seq_ESCs_Human1.47007114
74PADI4_21655091_ChIP-ChIP_MCF-7_Human1.46879088
75ELK1_19687146_ChIP-ChIP_HELA_Human1.46444368
76SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45763872
77MYCN_18555785_ChIP-Seq_MESCs_Mouse1.45460275
78NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.44461843
79TP53_22127205_ChIP-Seq_IMR90_Human1.44399804
80ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.43490641
81RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.42761599
82POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.42020529
83SOX2_18692474_ChIP-Seq_MEFs_Mouse1.40802236
84PCGF2_27294783_Chip-Seq_NPCs_Mouse1.40575355
85POU3F2_20337985_ChIP-ChIP_501MEL_Human1.40546305
86POU5F1_16153702_ChIP-ChIP_HESCs_Human1.37493980
87AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36888088
88ZFX_18555785_ChIP-Seq_MESCs_Mouse1.35325459
89KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.34151567
90KLF4_18555785_ChIP-Seq_MESCs_Mouse1.32951236
91* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.32642968
92EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.32062842
93OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31388996
94CREB1_15753290_ChIP-ChIP_HEK293T_Human1.30547643
95PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.29397239
96WT1_19549856_ChIP-ChIP_CCG9911_Human1.29134771
97SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.26620762
98SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.26620762
99SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.26570342
100NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.25585231
101NANOG_18692474_ChIP-Seq_MEFs_Mouse1.24179623
102MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.23858584
103ATF3_27146783_Chip-Seq_COLON_Human1.23746877
104SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.22731045
105NANOG_21062744_ChIP-ChIP_HESCs_Human1.22121061
106* NANOG_16153702_ChIP-ChIP_HESCs_Human1.21911305
107POU5F1_16518401_ChIP-PET_MESCs_Mouse1.21895497
108SOX2_18692474_ChIP-Seq_MESCs_Mouse1.21379206
109SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.20465317
110OCT4_18692474_ChIP-Seq_MEFs_Mouse1.19253772
111TBX3_20139965_ChIP-Seq_ESCs_Mouse1.19150784
112ELK1_22589737_ChIP-Seq_MCF10A_Human1.18830697
113TBX3_20139965_ChIP-Seq_MESCs_Mouse1.17744992
114BRD4_25478319_ChIP-Seq_HGPS_Human1.17355875
115PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.16858660
116HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.15910359
117TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.15883060
118MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.15131578
119TAF15_26573619_Chip-Seq_HEK293_Human1.14407648
120* SMAD4_21799915_ChIP-Seq_A2780_Human1.12879011
121TP63_19390658_ChIP-ChIP_HaCaT_Human1.12741906
122TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.12106999
123TFEB_21752829_ChIP-Seq_HELA_Human1.12077501
124CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.12066790
125EZH2_27294783_Chip-Seq_NPCs_Mouse1.11261809
126MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10591352
127SOX2_16153702_ChIP-ChIP_HESCs_Human1.10358173
128* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.10316827
129NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.09932825
130ZFP281_18757296_ChIP-ChIP_E14_Mouse1.09720076
131POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.09195890
132SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08958593
133SOX17_20123909_ChIP-Seq_XEN_Mouse1.07408741
134NANOG_18692474_ChIP-Seq_MESCs_Mouse1.05832971
135SOX9_26525672_Chip-Seq_HEART_Mouse1.05710332
136NOTCH1_21737748_ChIP-Seq_TLL_Human1.03725745
137TTF2_22483619_ChIP-Seq_HELA_Human1.03399299
138STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.00849658
139KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.99569824
140TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.99122799
141TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98959090
142SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.98752070
143PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98163435
144FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.97639789
145ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.96906704
146DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.96819074
147ETS1_20019798_ChIP-Seq_JURKAT_Human0.96598816
148CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.96079235
149DCP1A_22483619_ChIP-Seq_HELA_Human0.94765734
150JUN_21703547_ChIP-Seq_K562_Human0.94491489
151ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.94030219
152EST1_17652178_ChIP-ChIP_JURKAT_Human0.94028206
153ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93624120
154GABP_17652178_ChIP-ChIP_JURKAT_Human0.93258464
155YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92918749
156ZFP281_27345836_Chip-Seq_ESCs_Mouse0.92851346
157TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91989682
158* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.91512284
159ISL1_27105846_Chip-Seq_CPCs_Mouse0.89639105
160CDX2_19796622_ChIP-Seq_MESCs_Mouse0.89373708
161NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.89012006
162TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.88868038

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.03409051
2MP0003705_abnormal_hypodermis_morpholog3.92956834
3MP0010352_gastrointestinal_tract_polyps3.38072202
4MP0005623_abnormal_meninges_morphology2.95815458
5MP0010030_abnormal_orbit_morphology2.74709615
6MP0005275_abnormal_skin_tensile2.57549574
7MP0003941_abnormal_skin_development2.50129952
8MP0000733_abnormal_muscle_development2.33055681
9MP0004957_abnormal_blastocyst_morpholog2.28431896
10MP0005171_absent_coat_pigmentation2.21561203
11MP0010368_abnormal_lymphatic_system2.18284457
12MP0003136_yellow_coat_color2.12114169
13MP0010307_abnormal_tumor_latency2.03615653
14MP0005503_abnormal_tendon_morphology2.03327764
15MP0003566_abnormal_cell_adhesion1.91777815
16MP0003111_abnormal_nucleus_morphology1.91756706
17MP0009053_abnormal_anal_canal1.88575849
18MP0003077_abnormal_cell_cycle1.86965120
19MP0004272_abnormal_basement_membrane1.86488957
20MP0000750_abnormal_muscle_regeneration1.78940905
21MP0002295_abnormal_pulmonary_circulatio1.76337662
22MP0005076_abnormal_cell_differentiation1.76166326
23MP0004197_abnormal_fetal_growth/weight/1.73928437
24MP0010094_abnormal_chromosome_stability1.73702299
25MP0008007_abnormal_cellular_replicative1.72289946
26MP0002084_abnormal_developmental_patter1.67814247
27MP0010234_abnormal_vibrissa_follicle1.65848285
28MP0001730_embryonic_growth_arrest1.63338462
29MP0002938_white_spotting1.60749910
30MP0000350_abnormal_cell_proliferation1.60573501
31MP0003283_abnormal_digestive_organ1.58803162
32MP0003091_abnormal_cell_migration1.58453421
33MP0004133_heterotaxia1.56850909
34MP0005023_abnormal_wound_healing1.55626119
35MP0000537_abnormal_urethra_morphology1.52039690
36MP0003950_abnormal_plasma_membrane1.50623515
37MP0003693_abnormal_embryo_hatching1.49653221
38MP0002085_abnormal_embryonic_tissue1.47373239
39MP0001672_abnormal_embryogenesis/_devel1.44671072
40MP0005380_embryogenesis_phenotype1.44671072
41MP0000569_abnormal_digit_pigmentation1.42639651
42MP0003119_abnormal_digestive_system1.42319572
43MP0005367_renal/urinary_system_phenotyp1.41632614
44MP0000516_abnormal_urinary_system1.41632614
45MP0002086_abnormal_extraembryonic_tissu1.40360152
46MP0001697_abnormal_embryo_size1.39431169
47MP0001293_anophthalmia1.39109383
48MP0003279_aneurysm1.34033135
49MP0003984_embryonic_growth_retardation1.33490935
50MP0000767_abnormal_smooth_muscle1.32781239
51MP0002254_reproductive_system_inflammat1.32396974
52MP0008932_abnormal_embryonic_tissue1.32095776
53MP0002088_abnormal_embryonic_growth/wei1.32024764
54MP0003755_abnormal_palate_morphology1.31823593
55MP0003937_abnormal_limbs/digits/tail_de1.31615448
56MP0000534_abnormal_ureter_morphology1.31569264
57MP0005248_abnormal_Harderian_gland1.31169106
58MP0002751_abnormal_autonomic_nervous1.29873515
59MP0008789_abnormal_olfactory_epithelium1.28708991
60MP0000049_abnormal_middle_ear1.28206675
61MP0003806_abnormal_nucleotide_metabolis1.27008152
62MP0002877_abnormal_melanocyte_morpholog1.26212406
63MP0003890_abnormal_embryonic-extraembry1.24850540
64MP0000428_abnormal_craniofacial_morphol1.24632870
65MP0004233_abnormal_muscle_weight1.24527852
66MP0005508_abnormal_skeleton_morphology1.24320286
67MP0002697_abnormal_eye_size1.19880888
68MP0002060_abnormal_skin_morphology1.19342497
69MP0002108_abnormal_muscle_morphology1.18970788
70MP0003385_abnormal_body_wall1.18758536
71MP0002111_abnormal_tail_morphology1.18392178
72MP0002269_muscular_atrophy1.17727571
73MP0004087_abnormal_muscle_fiber1.17595493
74MP0005257_abnormal_intraocular_pressure1.15856860
75MP0001915_intracranial_hemorrhage1.15201641
76MP0000749_muscle_degeneration1.14262929
77MP0000747_muscle_weakness1.13904290
78MP0009384_cardiac_valve_regurgitation1.13116104
79MP0010386_abnormal_urinary_bladder1.10701971
80MP0000432_abnormal_head_morphology1.09870671
81MP0009697_abnormal_copulation1.09106958
82MP0002080_prenatal_lethality1.08335816
83MP0002932_abnormal_joint_morphology1.08234297
84MP0001299_abnormal_eye_distance/1.08118312
85MP0001849_ear_inflammation1.07471634
86MP0004084_abnormal_cardiac_muscle1.07431224
87MP0000759_abnormal_skeletal_muscle1.07327780
88MP0009250_abnormal_appendicular_skeleto1.04877735
89MP0001348_abnormal_lacrimal_gland1.04455936
90MP0002092_abnormal_eye_morphology1.03911481
91MP0003123_paternal_imprinting1.02043339
92MP0003115_abnormal_respiratory_system1.01286645
93MP0008057_abnormal_DNA_replication1.00323279
94MP0003567_abnormal_fetal_cardiomyocyte1.00185910
95MP0005197_abnormal_uvea_morphology0.99015980
96MP0000538_abnormal_urinary_bladder0.95229195
97MP0000751_myopathy0.95069392
98MP0001286_abnormal_eye_development0.93343889
99MP0003935_abnormal_craniofacial_develop0.92207952
100MP0002282_abnormal_trachea_morphology0.91942112
101MP0003942_abnormal_urinary_system0.91117886
102MP0001529_abnormal_vocalization0.90950466
103MP0001879_abnormal_lymphatic_vessel0.89671940
104MP0002896_abnormal_bone_mineralization0.89539971
105MP0001958_emphysema0.89426035
106MP0000762_abnormal_tongue_morphology0.89323133
107MP0004145_abnormal_muscle_electrophysio0.88541127
108MP0008058_abnormal_DNA_repair0.88200907
109MP0001542_abnormal_bone_strength0.87080364
110MP0002925_abnormal_cardiovascular_devel0.87060557
111MP0005499_abnormal_olfactory_system0.87010522
112MP0005394_taste/olfaction_phenotype0.87010522
113MP0004134_abnormal_chest_morphology0.87004687
114MP0002233_abnormal_nose_morphology0.86879841
115MP0002249_abnormal_larynx_morphology0.86827170
116MP0002106_abnormal_muscle_physiology0.85548361
117MP0000490_abnormal_crypts_of0.85452607
118MP0005501_abnormal_skin_physiology0.85412129
119MP0005595_abnormal_vascular_smooth0.84382159
120MP0005408_hypopigmentation0.84263255
121MP0005369_muscle_phenotype0.84011208
122MP0002128_abnormal_blood_circulation0.83873334
123MP0002109_abnormal_limb_morphology0.82432441
124MP0002114_abnormal_axial_skeleton0.81929894
125MP0002116_abnormal_craniofacial_bone0.80947714
126MP0006054_spinal_hemorrhage0.80933374
127MP0002177_abnormal_outer_ear0.79379917
128MP0001177_atelectasis0.79345109
129MP0000462_abnormal_digestive_system0.79054972
130MP0005187_abnormal_penis_morphology0.78875717
131MP0000163_abnormal_cartilage_morphology0.78445101
132MP0002089_abnormal_postnatal_growth/wei0.77290830
133MP0005193_abnormal_anterior_eye0.74822171
134MP0002115_abnormal_skeleton_extremities0.70001414
135MP0001661_extended_life_span0.69043105
136MP0002102_abnormal_ear_morphology0.68139163
137MP0001270_distended_abdomen0.67391527

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.32717354
2Follicular hyperkeratosis (HP:0007502)4.24447096
3Premature rupture of membranes (HP:0001788)4.18165385
4Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.14963307
5Muscle fiber inclusion bodies (HP:0100299)4.00033769
6Type 1 muscle fiber predominance (HP:0003803)3.78732742
7Nemaline bodies (HP:0003798)3.71288366
8Entropion (HP:0000621)3.69840447
9Round ear (HP:0100830)3.54053992
10Distal arthrogryposis (HP:0005684)3.40253294
11Increased connective tissue (HP:0009025)3.29599636
12Neonatal short-limb short stature (HP:0008921)3.21895125
13Shallow orbits (HP:0000586)3.12882963
14Bladder diverticulum (HP:0000015)3.11326619
15Ankle contracture (HP:0006466)2.96734346
16Broad metatarsal (HP:0001783)2.94562349
17Abnormality of the calcaneus (HP:0008364)2.90664471
18Spondylolisthesis (HP:0003302)2.90633397
19Calcaneovalgus deformity (HP:0001848)2.84981234
20Ulnar deviation of the wrist (HP:0003049)2.74382364
21Difficulty climbing stairs (HP:0003551)2.73014648
22Trismus (HP:0000211)2.72293833
23Soft skin (HP:0000977)2.61566523
24Wrist flexion contracture (HP:0001239)2.60680184
25Deformed tarsal bones (HP:0008119)2.56865454
26Aortic dissection (HP:0002647)2.56644647
27Bowel diverticulosis (HP:0005222)2.55595997
28Ependymoma (HP:0002888)2.54893765
29Missing ribs (HP:0000921)2.53701711
30Spinal rigidity (HP:0003306)2.52706477
31Malignant hyperthermia (HP:0002047)2.52077231
32Coronal craniosynostosis (HP:0004440)2.51799339
33Wide anterior fontanel (HP:0000260)2.51130604
34Cerebral aneurysm (HP:0004944)2.50644545
35Poikiloderma (HP:0001029)2.50279383
36Colon cancer (HP:0003003)2.48671180
37Breech presentation (HP:0001623)2.48334695
38Cutaneous melanoma (HP:0012056)2.46790015
39Distal lower limb muscle weakness (HP:0009053)2.42978859
40Fused cervical vertebrae (HP:0002949)2.39933997
41Hyporeflexia of lower limbs (HP:0002600)2.39894313
42Difficulty running (HP:0009046)2.38982448
43Myopathic facies (HP:0002058)2.34425812
44Pelvic girdle muscle weakness (HP:0003749)2.34398529
45Biconcave vertebral bodies (HP:0004586)2.31498666
46Pterygium (HP:0001059)2.31456970
47Vitreoretinal degeneration (HP:0000655)2.31167006
48Abnormality of the astrocytes (HP:0100707)2.30463534
49Astrocytoma (HP:0009592)2.30463534
50Hypoplastic pelvis (HP:0008839)2.27357646
51Selective tooth agenesis (HP:0001592)2.26999552
52Hip contracture (HP:0003273)2.25263438
53Distal lower limb amyotrophy (HP:0008944)2.24059895
54Abnormality of dentin (HP:0010299)2.23739178
55Increased density of long bones (HP:0006392)2.22528209
56Popliteal pterygium (HP:0009756)2.22161203
57Dilatation of the ascending aorta (HP:0005111)2.20559598
58Aplasia of the musculature (HP:0100854)2.20194418
59Shoulder girdle muscle weakness (HP:0003547)2.20070825
60Atrophic scars (HP:0001075)2.19986275
61Absent phalangeal crease (HP:0006109)2.19755616
62Cervical subluxation (HP:0003308)2.19506880
63Genu recurvatum (HP:0002816)2.17169360
64Squamous cell carcinoma (HP:0002860)2.17148550
65Absent frontal sinuses (HP:0002688)2.16966158
66Abnormal hemoglobin (HP:0011902)2.16735920
67Muscle fiber splitting (HP:0003555)2.16267934
68Mildly elevated creatine phosphokinase (HP:0008180)2.13676188
69Short humerus (HP:0005792)2.11154652
70Mesomelia (HP:0003027)2.08068342
71Broad long bones (HP:0005622)2.07577908
72Vertebral compression fractures (HP:0002953)2.07203339
73Rib fusion (HP:0000902)2.07014448
74Thin ribs (HP:0000883)2.06977236
75Exercise-induced muscle cramps (HP:0003710)2.06289616
76Aplasia/hypoplasia of the humerus (HP:0006507)2.05712793
77Abnormality of the labia minora (HP:0012880)2.05467259
78Abnormality of the musculature of the pelvis (HP:0001469)2.04850463
79Abnormality of the hip-girdle musculature (HP:0001445)2.04850463
80Abdominal situs inversus (HP:0003363)2.03510610
81Abnormality of abdominal situs (HP:0011620)2.03510610
82Syringomyelia (HP:0003396)2.02783529
83Spinal cord lesions (HP:0100561)2.02783529
84Joint laxity (HP:0001388)1.99411219
85Fragile skin (HP:0001030)1.98847094
86Vertebral fusion (HP:0002948)1.98308927
87Radial bowing (HP:0002986)1.98184667
88Partial duplication of the phalanx of hand (HP:0009999)1.97561863
89Scapular winging (HP:0003691)1.97374426
90Abnormality of the fetal cardiovascular system (HP:0010948)1.96730609
91Abnormal umbilical cord blood vessels (HP:0011403)1.96730609
92Single umbilical artery (HP:0001195)1.96730609
93Aortic regurgitation (HP:0001659)1.96566734
94Protruding ear (HP:0000411)1.96379779
95Camptodactyly of toe (HP:0001836)1.95550408
96Biliary tract neoplasm (HP:0100574)1.94309763
97Increased corneal curvature (HP:0100692)1.93280412
98Keratoconus (HP:0000563)1.93280412
99Abnormality of skeletal muscle fiber size (HP:0012084)1.92885554
100Hyperextensible skin (HP:0000974)1.92451699
101Abnormality of the acetabulum (HP:0003170)1.92153965
102Glioma (HP:0009733)1.91067043
103Delayed closure of the anterior fontanelle (HP:0001476)1.90721600
104Gastrointestinal carcinoma (HP:0002672)1.90078225
105Malignant gastrointestinal tract tumors (HP:0006749)1.90078225
106Deviation of the thumb (HP:0009603)1.89705681
107Overgrowth (HP:0001548)1.89129637
108Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.88388513
109Delayed cranial suture closure (HP:0000270)1.87884351
110Bifid tongue (HP:0010297)1.87819720
111Distal upper limb amyotrophy (HP:0007149)1.85805172
112Upper limb amyotrophy (HP:0009129)1.85805172
113Abnormal finger flexion creases (HP:0006143)1.83941789
114Inguinal hernia (HP:0000023)1.83755586
115Blue sclerae (HP:0000592)1.83141934
116Aortic aneurysm (HP:0004942)1.82681531
117EMG: myopathic abnormalities (HP:0003458)1.82049228
118Amniotic constriction ring (HP:0009775)1.81683435
119Abnormality of placental membranes (HP:0011409)1.81683435
120Microglossia (HP:0000171)1.81151937
121Cystic hygroma (HP:0000476)1.81009713
122Neoplasm of the oral cavity (HP:0100649)1.80880664
123Limb-girdle muscle weakness (HP:0003325)1.79962912
124Aortic valve stenosis (HP:0001650)1.78531067
125Wormian bones (HP:0002645)1.78075885
126Long clavicles (HP:0000890)1.77448364
127Limited hip movement (HP:0008800)1.76977604
128Vertebral hypoplasia (HP:0008417)1.76544141
129Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.76544141
130Short 1st metacarpal (HP:0010034)1.75776591
131Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.75776591
132Vascular tortuosity (HP:0004948)1.75559550
133Broad phalanx (HP:0006009)1.75034743
134Vertebral clefting (HP:0008428)1.74316623
135Renal duplication (HP:0000075)1.74086680
136Decreased skull ossification (HP:0004331)1.73279060
137Knee flexion contracture (HP:0006380)1.73200633
138Slender build (HP:0001533)1.72574497
139Medulloblastoma (HP:0002885)1.72271837
140Small epiphyses (HP:0010585)1.71597258
141Mild short stature (HP:0003502)1.71229082
142Fetal akinesia sequence (HP:0001989)1.70840883
143Arterial tortuosity (HP:0005116)1.70098456
144Mitral valve prolapse (HP:0001634)1.69972630
145Pulmonary artery stenosis (HP:0004415)1.66984983
146Elbow flexion contracture (HP:0002987)1.66823034
147Abnormality of skull ossification (HP:0002703)1.66412631
148Abnormality of the umbilical cord (HP:0010881)1.64797010
149Ulnar bowing (HP:0003031)1.64528516
150Abnormal delivery (HP:0001787)1.64472448
151Occipital encephalocele (HP:0002085)1.63948871
152Mitral stenosis (HP:0001718)1.61649012
153Delayed gross motor development (HP:0002194)1.60952980
154Dental crowding (HP:0000678)1.60430330
155Partial duplication of thumb phalanx (HP:0009944)1.59047672
156Morphological abnormality of the middle ear (HP:0008609)1.58937906
157Redundant skin (HP:0001582)1.55833818
158Hypoventilation (HP:0002791)1.55180202
159Ectopia lentis (HP:0001083)1.54594335
160Rhizomelia (HP:0008905)1.54552295
161Short middle phalanx of the 5th finger (HP:0004220)1.53508903
162Peritonitis (HP:0002586)1.52991964
163Hypoplasia of the iris (HP:0007676)1.51880477
164Pulmonic stenosis (HP:0001642)1.51592986
165Natal tooth (HP:0000695)1.50464808
166Cupped ribs (HP:0000887)1.50044049
167Mitral regurgitation (HP:0001653)1.49560267
168Short 5th finger (HP:0009237)1.47063616
169Hypoplastic ischia (HP:0003175)1.46951047
170Hyperglycinemia (HP:0002154)1.46695414
171Hypoplastic scapulae (HP:0000882)1.45862865

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.58533275
2TTN2.95045594
3CDK122.93704542
4MYLK2.65169322
5NEK12.60321054
6DDR22.59844545
7PLK22.48696557
8LATS12.43195495
9CDC72.19437498
10RPS6KB22.12756072
11WEE12.04039271
12LATS21.94147015
13PKN21.91095471
14TTK1.89706349
15PDGFRA1.87385211
16NTRK11.86127533
17TAF11.85504575
18TRIB31.79442511
19EEF2K1.75400324
20PAK41.71862989
21TNIK1.65361517
22AKT31.65097728
23CDK61.63707940
24SCYL21.58609223
25MKNK21.54006498
26ZAK1.52261016
27NEK21.50360446
28PIM21.46605475
29VRK21.45407998
30MOS1.45286335
31PLK11.43645708
32PTK21.41322063
33ERBB41.40100851
34BUB11.37203150
35MET1.34001071
36TESK11.30091769
37FER1.29251613
38PAK21.28646468
39LIMK11.27705921
40AURKB1.23663384
41EIF2AK11.23520189
42NUAK11.21209889
43DYRK1B1.18932660
44MTOR1.13947657
45PLK31.11563140
46PASK1.10216729
47MAP3K81.10061222
48TRPM71.07534616
49CDK71.07296405
50STK31.04981268
51FGFR11.01923617
52ACVR1B1.01108138
53BMX1.01046907
54LRRK20.99980461
55PRKCE0.99192217
56OBSCN0.99003195
57WNK30.98127195
58ALK0.97561824
59ROCK20.96651341
60MAPKAPK30.95948182
61TGFBR10.94683461
62SRPK10.93834776
63STK100.92079038
64CHEK20.91443190
65EPHB20.91287523
66PTK60.90501050
67ATR0.89996303
68PDK30.89780146
69PDK40.89780146
70CHEK10.89748080
71TGFBR20.88223592
72BMPR1B0.87879187
73PAK30.87877180
74RIPK10.87100223
75STK38L0.86962234
76TLK10.85890798
77PLK40.85539798
78MAP3K100.84020198
79PBK0.83254119
80PIK3CG0.82878904
81FGFR20.81910415
82FLT30.81446586
83MKNK10.78692586
84ROCK10.77004426
85PAK60.76903763
86CASK0.76448787
87TSSK60.76176614
88DYRK30.76122043
89FRK0.76032288
90PDK20.75072611
91CSNK1A1L0.73679940
92AKT20.73111230
93TESK20.72722388
94BRD40.68981169
95ERBB30.67694393
96PDGFRB0.66690373
97MUSK0.66307911
98BRSK10.66152838
99PIM10.65862467
100CSNK1G10.65849835
101DAPK30.65220091
102BRSK20.65059289
103CDK20.64373912
104PIK3CA0.64332168
105AURKA0.64230664
106EIF2AK30.61659238
107ATM0.61542328
108PRKD20.60488641
109MAP2K10.60072525
110PRKCI0.59980690
111RPS6KA40.59859475
112MAPKAPK50.59407949
113CSNK1D0.58664028
114GRK10.58234950
115CDK40.58234622
116TYRO30.57822374
117MELK0.57692911
118ILK0.57202748
119CDK90.56682197
120NEK90.55621781
121MAP4K20.54040221
122CCNB10.52957369
123NME20.52908019
124STK40.52833651
125ABL20.52138489
126CSNK1E0.51790089
127TRIM280.50691763
128BCR0.48425812
129CDK10.47695752
130WNK40.47240615
131CSNK1G30.46661002
132CDK140.46243567
133PAK10.46087327
134MAP3K50.43988437
135TIE10.43955083
136ADRBK10.42848886
137DYRK20.41619477
138GSK3A0.41562733
139EIF2AK20.39388824
140STK160.38895331
141CLK10.38737997
142ADRBK20.36143924
143VRK10.35700016
144CSNK1G20.35402791
145PRKCG0.34134848
146CDK80.33827131
147PTK2B0.32908225
148WNK10.30725192

Predicted pathways (KEGG)

RankGene SetZ-score
1p53 signaling pathway_Homo sapiens_hsa041153.21810263
2Protein export_Homo sapiens_hsa030603.16588463
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.85579369
4One carbon pool by folate_Homo sapiens_hsa006702.78375284
5RNA transport_Homo sapiens_hsa030132.71570937
6Mismatch repair_Homo sapiens_hsa034302.70654527
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.67609577
8DNA replication_Homo sapiens_hsa030302.36635594
9Cell cycle_Homo sapiens_hsa041102.35185707
10Bladder cancer_Homo sapiens_hsa052192.15627775
11Adherens junction_Homo sapiens_hsa045202.10175210
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.05805295
13Hippo signaling pathway_Homo sapiens_hsa043902.03331546
14MicroRNAs in cancer_Homo sapiens_hsa052062.01642681
15ECM-receptor interaction_Homo sapiens_hsa045121.98833890
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.97319342
17Nucleotide excision repair_Homo sapiens_hsa034201.95123265
18Spliceosome_Homo sapiens_hsa030401.89518913
19Small cell lung cancer_Homo sapiens_hsa052221.87964621
20Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.83750273
21Propanoate metabolism_Homo sapiens_hsa006401.78504714
22Steroid biosynthesis_Homo sapiens_hsa001001.77679297
23Proteoglycans in cancer_Homo sapiens_hsa052051.73397442
24Basal cell carcinoma_Homo sapiens_hsa052171.72092461
25Focal adhesion_Homo sapiens_hsa045101.71583462
26TGF-beta signaling pathway_Homo sapiens_hsa043501.71118558
27Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.70674633
28Tight junction_Homo sapiens_hsa045301.62855096
29Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.62154538
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.59627032
31Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.56794038
32mRNA surveillance pathway_Homo sapiens_hsa030151.52591239
33Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.52124893
34Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.48096836
35Systemic lupus erythematosus_Homo sapiens_hsa053221.45498433
36Viral carcinogenesis_Homo sapiens_hsa052031.42943684
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.36221990
38Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.36198973
39Ribosome_Homo sapiens_hsa030101.33894474
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.33202529
41Hedgehog signaling pathway_Homo sapiens_hsa043401.29012884
42Chronic myeloid leukemia_Homo sapiens_hsa052201.28980826
43N-Glycan biosynthesis_Homo sapiens_hsa005101.27472730
44Proteasome_Homo sapiens_hsa030501.24606872
45Homologous recombination_Homo sapiens_hsa034401.23292576
46Melanoma_Homo sapiens_hsa052181.23196123
47Vitamin B6 metabolism_Homo sapiens_hsa007501.22451517
48Fanconi anemia pathway_Homo sapiens_hsa034601.22045406
49Glutathione metabolism_Homo sapiens_hsa004801.20777594
50Base excision repair_Homo sapiens_hsa034101.17815924
51RNA polymerase_Homo sapiens_hsa030201.14776845
52RNA degradation_Homo sapiens_hsa030181.13791875
53Cysteine and methionine metabolism_Homo sapiens_hsa002701.12354205
54Dilated cardiomyopathy_Homo sapiens_hsa054141.11844859
55Non-homologous end-joining_Homo sapiens_hsa034501.09635908
56Viral myocarditis_Homo sapiens_hsa054161.09538031
57HTLV-I infection_Homo sapiens_hsa051661.08849857
58Thyroid cancer_Homo sapiens_hsa052161.08636355
59Central carbon metabolism in cancer_Homo sapiens_hsa052301.07463412
60Amoebiasis_Homo sapiens_hsa051461.04745200
61Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.03682272
62Regulation of actin cytoskeleton_Homo sapiens_hsa048100.99646946
63mTOR signaling pathway_Homo sapiens_hsa041500.97932327
64Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.97883397
65Pathways in cancer_Homo sapiens_hsa052000.93054795
66Biosynthesis of amino acids_Homo sapiens_hsa012300.92473077
67Colorectal cancer_Homo sapiens_hsa052100.92467588
68AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.91457665
69Prostate cancer_Homo sapiens_hsa052150.91320700
70Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.90509589
71PI3K-Akt signaling pathway_Homo sapiens_hsa041510.90338675
72Glycosaminoglycan degradation_Homo sapiens_hsa005310.89981849
73Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.89649683
74Arginine and proline metabolism_Homo sapiens_hsa003300.87789393
75Leukocyte transendothelial migration_Homo sapiens_hsa046700.86440033
76Selenocompound metabolism_Homo sapiens_hsa004500.86152613
77Epstein-Barr virus infection_Homo sapiens_hsa051690.85512923
78HIF-1 signaling pathway_Homo sapiens_hsa040660.85243242
79Endometrial cancer_Homo sapiens_hsa052130.85096832
80Fatty acid elongation_Homo sapiens_hsa000620.82810459
81Wnt signaling pathway_Homo sapiens_hsa043100.80624246
82Pyruvate metabolism_Homo sapiens_hsa006200.77761488
83Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.76672265
84Apoptosis_Homo sapiens_hsa042100.76298893
85Complement and coagulation cascades_Homo sapiens_hsa046100.75882975
86Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.75303818
87Shigellosis_Homo sapiens_hsa051310.73691449
88FoxO signaling pathway_Homo sapiens_hsa040680.72512421
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72223237
90Oocyte meiosis_Homo sapiens_hsa041140.71809129
91Glioma_Homo sapiens_hsa052140.71354646
922-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.71013000
93Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.70368407
94Fructose and mannose metabolism_Homo sapiens_hsa000510.70282594
95Fatty acid metabolism_Homo sapiens_hsa012120.68322389
96Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63234837
97Circadian rhythm_Homo sapiens_hsa047100.62390381
98Pyrimidine metabolism_Homo sapiens_hsa002400.61001863
99Basal transcription factors_Homo sapiens_hsa030220.60059062
100Thyroid hormone synthesis_Homo sapiens_hsa049180.59012348
101Pancreatic cancer_Homo sapiens_hsa052120.57300450
102Legionellosis_Homo sapiens_hsa051340.56565555
103Renal cell carcinoma_Homo sapiens_hsa052110.56551613
104Carbon metabolism_Homo sapiens_hsa012000.53613289
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.52643286
106Notch signaling pathway_Homo sapiens_hsa043300.52115222
107Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.51524639
108Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49148802
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47829882
110Hepatitis B_Homo sapiens_hsa051610.47689630
111Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46799142
112Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46345206
113Salmonella infection_Homo sapiens_hsa051320.45603406
114Alcoholism_Homo sapiens_hsa050340.44346338
115Folate biosynthesis_Homo sapiens_hsa007900.43728954
116Fatty acid degradation_Homo sapiens_hsa000710.43166770
117Rap1 signaling pathway_Homo sapiens_hsa040150.43161951
118Non-small cell lung cancer_Homo sapiens_hsa052230.42678589
119Peroxisome_Homo sapiens_hsa041460.41667952
120Primary bile acid biosynthesis_Homo sapiens_hsa001200.41439199
121AMPK signaling pathway_Homo sapiens_hsa041520.41276886
122Protein digestion and absorption_Homo sapiens_hsa049740.41151006
123Metabolic pathways_Homo sapiens_hsa011000.39734817
124Lysine degradation_Homo sapiens_hsa003100.39578508
125Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38983022
126Phototransduction_Homo sapiens_hsa047440.37114959
127Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37014059
128Insulin signaling pathway_Homo sapiens_hsa049100.36825782
129Purine metabolism_Homo sapiens_hsa002300.36470807
130ErbB signaling pathway_Homo sapiens_hsa040120.34914845
131Galactose metabolism_Homo sapiens_hsa000520.34856635
132Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.32408328
133Pentose phosphate pathway_Homo sapiens_hsa000300.32281195
134Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.32010911
135Malaria_Homo sapiens_hsa051440.30744270
136Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.28573333
137Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28001471
138Melanogenesis_Homo sapiens_hsa049160.27806945
139Axon guidance_Homo sapiens_hsa043600.26600042

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »