EDC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: EDC3 is associated with an mRNA-decapping complex required for removal of the 5-prime cap from mRNA prior to its degradation from the 5-prime end (Fenger-Gron et al., 2005 [PubMed 16364915]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1daunorubicin metabolic process (GO:0044597)6.61156564
2polyketide metabolic process (GO:0030638)6.61156564
3doxorubicin metabolic process (GO:0044598)6.61156564
4protein localization to kinetochore (GO:0034501)5.59060993
5regulation of telomere maintenance via telomerase (GO:0032210)5.08844042
6ribosomal small subunit biogenesis (GO:0042274)5.06151440
7maintenance of protein location in nucleus (GO:0051457)4.99536465
8regulation of nuclear cell cycle DNA replication (GO:0033262)4.88531129
9rRNA transcription (GO:0009303)4.85295757
10GDP-mannose metabolic process (GO:0019673)4.81646037
11DNA replication checkpoint (GO:0000076)4.77481563
12negative regulation of telomerase activity (GO:0051974)4.69532786
13histone H4-K8 acetylation (GO:0043982)4.65892271
14histone H4-K5 acetylation (GO:0043981)4.65892271
15regulation of mammary gland epithelial cell proliferation (GO:0033599)4.59225685
16negative regulation of epidermis development (GO:0045683)4.55456111
17mitotic sister chromatid segregation (GO:0000070)4.40739057
18DNA damage response, detection of DNA damage (GO:0042769)4.37516706
19somite rostral/caudal axis specification (GO:0032525)4.37323824
20protein localization to chromosome, centromeric region (GO:0071459)4.36559921
21DNA unwinding involved in DNA replication (GO:0006268)4.34656634
22L-serine metabolic process (GO:0006563)4.30208545
23histone H4-K12 acetylation (GO:0043983)4.28834948
24negative regulation of telomere maintenance (GO:0032205)4.26980099
25regulation of response to osmotic stress (GO:0047484)4.21829873
26DNA replication-dependent nucleosome assembly (GO:0006335)4.19365769
27DNA replication-dependent nucleosome organization (GO:0034723)4.19365769
28negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.17428821
29regulation of translational fidelity (GO:0006450)4.10017144
30spliceosomal tri-snRNP complex assembly (GO:0000244)4.10009249
31DNA strand elongation (GO:0022616)4.04110775
32viral transcription (GO:0019083)4.02981959
33negative regulation of cell cycle G2/M phase transition (GO:1902750)4.01282937
34regulation of translation in response to stress (GO:0043555)4.01118714
35peptidyl-arginine omega-N-methylation (GO:0035247)3.94085211
36aminoglycoside antibiotic metabolic process (GO:0030647)3.93544298
37formation of translation preinitiation complex (GO:0001731)3.88523664
38translational termination (GO:0006415)3.87791887
39heterochromatin organization (GO:0070828)3.85291658
40proline biosynthetic process (GO:0006561)3.83175876
41rRNA modification (GO:0000154)3.79723926
42nuclear pore complex assembly (GO:0051292)3.78432244
43rRNA methylation (GO:0031167)3.77612134
44negative regulation of epidermal cell differentiation (GO:0045605)3.73820647
45maturation of SSU-rRNA (GO:0030490)3.73122184
46Golgi transport vesicle coating (GO:0048200)3.72606232
47COPI coating of Golgi vesicle (GO:0048205)3.72606232
48sister chromatid segregation (GO:0000819)3.70081692
49positive regulation of DNA-dependent DNA replication (GO:2000105)3.69222693
50histone H4-K16 acetylation (GO:0043984)3.66576986
51interferon-gamma production (GO:0032609)3.61576201
52regulation of MHC class I biosynthetic process (GO:0045343)3.59207259
53ribonucleoprotein complex biogenesis (GO:0022613)3.58853520
54cullin deneddylation (GO:0010388)3.58423639
55chromatin assembly (GO:0031497)3.57513498
56pre-miRNA processing (GO:0031054)3.54779087
57IMP biosynthetic process (GO:0006188)3.54714622
58serine family amino acid biosynthetic process (GO:0009070)3.54462799
59muscle organ morphogenesis (GO:0048644)3.54412780
60negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.50694833
61telomere maintenance via semi-conservative replication (GO:0032201)3.49879174
62chaperone-mediated protein transport (GO:0072321)3.49602142
63peptidyl-arginine methylation (GO:0018216)3.45087396
64peptidyl-arginine N-methylation (GO:0035246)3.45087396
65nuclear pore organization (GO:0006999)3.44459886
66negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.42577297
67folic acid-containing compound biosynthetic process (GO:0009396)3.42082633
68nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.42050930
69histone H2A acetylation (GO:0043968)3.39921781
70DNA replication initiation (GO:0006270)3.39328143
71ribosome biogenesis (GO:0042254)3.34790767
72protein deneddylation (GO:0000338)3.34623956
73DNA duplex unwinding (GO:0032508)3.34141608
74pseudouridine synthesis (GO:0001522)3.34124637
75DNA geometric change (GO:0032392)3.32301138
76regulation of telomere maintenance (GO:0032204)3.31697403
77cell fate commitment involved in formation of primary germ layer (GO:0060795)3.30294369
78RNA stabilization (GO:0043489)3.26818164
79mRNA stabilization (GO:0048255)3.26818164
80histone arginine methylation (GO:0034969)3.26653741
81mitotic chromosome condensation (GO:0007076)3.21340136
82nucleoside transmembrane transport (GO:1901642)3.21081245
83SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.19194424
84tRNA aminoacylation for protein translation (GO:0006418)3.18448350
85mitotic nuclear envelope disassembly (GO:0007077)3.18373301
86cotranslational protein targeting to membrane (GO:0006613)3.16280338
87translational elongation (GO:0006414)3.15523811
88protein targeting to ER (GO:0045047)3.13911302
89regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.13704812
90primitive streak formation (GO:0090009)3.13514200
91mitochondrial DNA metabolic process (GO:0032042)3.10467842
92regulation of telomerase activity (GO:0051972)3.09988454
93translational initiation (GO:0006413)3.08315298
94tRNA aminoacylation (GO:0043039)3.07224862
95amino acid activation (GO:0043038)3.07224862
96cellular protein complex disassembly (GO:0043624)3.05577644
97meiotic chromosome segregation (GO:0045132)3.05485577
98purine nucleobase biosynthetic process (GO:0009113)3.02619744
99viral life cycle (GO:0019058)3.02376947
100membrane disassembly (GO:0030397)3.02355285
101nuclear envelope disassembly (GO:0051081)3.02355285
102spliceosomal complex assembly (GO:0000245)3.02136047
103establishment of integrated proviral latency (GO:0075713)3.01836737
104IMP metabolic process (GO:0046040)3.01431687
105negative regulation of mRNA processing (GO:0050686)3.00576991
106regulation of posttranscriptional gene silencing (GO:0060147)3.00204780
107regulation of gene silencing by miRNA (GO:0060964)3.00204780
108regulation of gene silencing by RNA (GO:0060966)3.00204780
109regulation of chromatin binding (GO:0035561)2.98583860
110protein-DNA complex disassembly (GO:0032986)2.98286778
111nucleosome disassembly (GO:0006337)2.98286778
112establishment of protein localization to endoplasmic reticulum (GO:0072599)2.97721465
113mitotic metaphase plate congression (GO:0007080)2.97438483
114protein complex disassembly (GO:0043241)2.96921874
115nucleobase biosynthetic process (GO:0046112)2.96504785
116ribosomal small subunit assembly (GO:0000028)2.95780290
117spliceosomal snRNP assembly (GO:0000387)2.93572909
118mitochondrial RNA metabolic process (GO:0000959)2.93007872
119DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.92536779
120pore complex assembly (GO:0046931)2.92367311
121regulation of cilium movement (GO:0003352)2.92146542
122negative regulation of gene silencing (GO:0060969)2.91411590
123regulation of histone H3-K4 methylation (GO:0051569)2.90875416
124folic acid metabolic process (GO:0046655)2.90645501
125ribosomal large subunit biogenesis (GO:0042273)2.88853601
126protein localization to endoplasmic reticulum (GO:0070972)2.88349790
127DNA topological change (GO:0006265)2.87918801
128regulation of apoptotic process involved in morphogenesis (GO:1902337)2.86689327
129positive regulation of histone H3-K4 methylation (GO:0051571)2.85941623
130regulation of translational elongation (GO:0006448)2.84398478
131mannose metabolic process (GO:0006013)2.84303053
132protein insertion into membrane (GO:0051205)2.83977834
133base-excision repair (GO:0006284)2.83019937
134cytidine metabolic process (GO:0046087)2.82937692
135cytidine catabolic process (GO:0006216)2.82937692
136cytidine deamination (GO:0009972)2.82937692
137coenzyme A biosynthetic process (GO:0015937)2.82856272
138branching involved in mammary gland duct morphogenesis (GO:0060444)2.81239173
139RNA localization (GO:0006403)2.79934647
140rRNA processing (GO:0006364)2.79440733
141chromosome condensation (GO:0030261)2.77442517
142guanosine-containing compound biosynthetic process (GO:1901070)2.76983138
143de novo posttranslational protein folding (GO:0051084)2.76956200
144peptidyl-histidine modification (GO:0018202)2.75844599
145pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.75534921
146macromolecular complex disassembly (GO:0032984)2.73952576
147transcription from mitochondrial promoter (GO:0006390)2.73161525
148protein localization to chromosome (GO:0034502)2.72196548
149rRNA metabolic process (GO:0016072)2.71844333
150regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.71562262
151cellular component biogenesis (GO:0044085)2.71065810
152telomere maintenance via recombination (GO:0000722)2.70933558
153trophectodermal cell differentiation (GO:0001829)2.70862031
154DNA strand elongation involved in DNA replication (GO:0006271)2.70861468
155positive regulation of chromosome segregation (GO:0051984)2.70426021
156mitotic sister chromatid cohesion (GO:0007064)2.69727737
157RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.69073378
158mRNA splicing, via spliceosome (GO:0000398)2.69073378
159nucleoside transport (GO:0015858)2.68833069
160proline metabolic process (GO:0006560)2.68763803
161pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.67969917
162de novo protein folding (GO:0006458)2.67574584
163mitotic recombination (GO:0006312)2.66665230
164nuclear envelope organization (GO:0006998)2.65103543
165negative regulation of RNA splicing (GO:0033119)2.64750419
166RNA splicing, via transesterification reactions (GO:0000375)2.63921024
167snRNA metabolic process (GO:0016073)2.61432022
168somatic diversification of immune receptors via somatic mutation (GO:0002566)2.61304048
169somatic hypermutation of immunoglobulin genes (GO:0016446)2.61304048
170protein complex localization (GO:0031503)2.59581852
171nucleotide-sugar biosynthetic process (GO:0009226)2.59386999
172negative regulation of mRNA metabolic process (GO:1903312)2.59069583
173UTP biosynthetic process (GO:0006228)2.57815748
174retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.56660671
175dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.54821325
176establishment of viral latency (GO:0019043)2.54651587
177nucleotide-excision repair, DNA gap filling (GO:0006297)2.54238553
178DNA ligation (GO:0006266)2.53600193

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.55291221
2KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.14504542
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.14504542
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.14504542
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.00969346
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.76299914
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.11794607
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.11418993
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.90526543
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.82174771
11TP63_19390658_ChIP-ChIP_HaCaT_Human2.66761350
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.55874270
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.48808480
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.27950065
15MYC_22102868_ChIP-Seq_BL_Human2.27664338
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.25585749
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.19768931
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.18538273
19SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.13307852
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.10131871
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.08928286
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.08731894
23NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.99504828
24ETS1_20019798_ChIP-Seq_JURKAT_Human1.90242043
25JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.87828004
26POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.87480506
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.85481462
28XRN2_22483619_ChIP-Seq_HELA_Human1.83775478
29GABP_17652178_ChIP-ChIP_JURKAT_Human1.80595940
30MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.79387146
31PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.73521428
32YY1_21170310_ChIP-Seq_MESCs_Mouse1.73148825
33SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.72391320
34POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.70796548
35HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.68999847
36TCF3_18692474_ChIP-Seq_MEFs_Mouse1.67953779
37TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.65016309
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64460334
39FOXP3_21729870_ChIP-Seq_TREG_Human1.58740122
40TCF3_18692474_ChIP-Seq_MESCs_Mouse1.55111644
41NOTCH1_21737748_ChIP-Seq_TLL_Human1.53910730
42NANOG_18555785_ChIP-Seq_MESCs_Mouse1.53616960
43POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.52852342
44CIITA_25753668_ChIP-Seq_RAJI_Human1.51318294
45KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.49320132
46ESR1_15608294_ChIP-ChIP_MCF-7_Human1.48031598
47* AR_21909140_ChIP-Seq_LNCAP_Human1.46945812
48VDR_23849224_ChIP-Seq_CD4+_Human1.46580914
49SOX2_18555785_ChIP-Seq_MESCs_Mouse1.46351029
50NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.46042226
51TTF2_22483619_ChIP-Seq_HELA_Human1.43108137
52SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.42916220
53ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.39524300
54IRF1_19129219_ChIP-ChIP_H3396_Human1.39214965
55CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.38268937
56STAT3_1855785_ChIP-Seq_MESCs_Mouse1.37271306
57VDR_21846776_ChIP-Seq_THP-1_Human1.36984842
58SCL_19346495_ChIP-Seq_HPC-7_Human1.36370633
59* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.34878895
60NELFA_20434984_ChIP-Seq_ESCs_Mouse1.33755104
61SRF_21415370_ChIP-Seq_HL-1_Mouse1.33601613
62KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.32852961
63ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.32572069
64THAP11_20581084_ChIP-Seq_MESCs_Mouse1.32442085
65* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.31792042
66SRY_22984422_ChIP-ChIP_TESTIS_Rat1.31549477
67HIF1A_21447827_ChIP-Seq_MCF-7_Human1.30573483
68ZNF263_19887448_ChIP-Seq_K562_Human1.30358845
69NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.29940434
70SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.29225876
71EGR1_19374776_ChIP-ChIP_THP-1_Human1.28808908
72KDM5A_27292631_Chip-Seq_BREAST_Human1.27702312
73* GABP_19822575_ChIP-Seq_HepG2_Human1.25785732
74BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.24547029
75HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.24022069
76CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.22887746
77OCT4_18692474_ChIP-Seq_MEFs_Mouse1.21813582
78NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.21381045
79NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.21291602
80SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.20052870
81PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.19545167
82FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.19145323
83TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.19133893
84MYCN_18555785_ChIP-Seq_MESCs_Mouse1.16370683
85ELF1_17652178_ChIP-ChIP_JURKAT_Human1.16275257
86DCP1A_22483619_ChIP-Seq_HELA_Human1.15069045
87SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.12689472
88POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.12646801
89TCF7_22412390_ChIP-Seq_EML_Mouse1.12166336
90CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.09677823
91NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.08294687
92TFEB_21752829_ChIP-Seq_HELA_Human1.06383907
93TET1_21451524_ChIP-Seq_MESCs_Mouse1.06298643
94CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.05565034
95ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04591917
96HOXB4_20404135_ChIP-ChIP_EML_Mouse1.04230814
97POU5F1_16518401_ChIP-PET_MESCs_Mouse1.04122704
98DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.03570875
99FOXP1_21924763_ChIP-Seq_HESCs_Human1.03483290
100KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02425098
101* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.01878319
102TBX5_21415370_ChIP-Seq_HL-1_Mouse1.01653827
103* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.00678548
104SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.00080318
105PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.00023180
106SOX2_18692474_ChIP-Seq_MEFs_Mouse0.99843585
107ZFX_18555785_ChIP-Seq_MESCs_Mouse0.99825356
108NANOG_21062744_ChIP-ChIP_HESCs_Human0.99701547
109P68_20966046_ChIP-Seq_HELA_Human0.99572749
110NANOG_18692474_ChIP-Seq_MEFs_Mouse0.98677068
111* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97646434
112PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97411276
113CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97209673
114ELK1_19687146_ChIP-ChIP_HELA_Human0.97193163
115YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97013058
116SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.96455887
117CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.95933961
118CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.95636462
119* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.94353378
120RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93843463
121TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93821256
122ZFP281_18757296_ChIP-ChIP_E14_Mouse0.92763433
123ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.92709810
124E2F1_17053090_ChIP-ChIP_MCF-7_Human0.92166125
125SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.91110027
126SPI1_23547873_ChIP-Seq_NB4_Human0.91102182
127SOX2_18692474_ChIP-Seq_MESCs_Mouse0.90198028
128YY1_22570637_ChIP-Seq_MALME-3M_Human0.90122197
129TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89987658
130DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.89838549
131E2F1_21310950_ChIP-Seq_MCF-7_Human0.89438040
132ELK3_25401928_ChIP-Seq_HUVEC_Human0.89250971
133NCOR1_26117541_ChIP-Seq_K562_Human0.89057259
134TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.88898220
135RACK7_27058665_Chip-Seq_MCF-7_Human0.86157738
136TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.86140919

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation3.88133496
2MP0006292_abnormal_olfactory_placode3.77540810
3MP0008057_abnormal_DNA_replication3.73478173
4MP0004957_abnormal_blastocyst_morpholog3.41081884
5MP0005499_abnormal_olfactory_system3.14201438
6MP0005394_taste/olfaction_phenotype3.14201438
7MP0005075_abnormal_melanosome_morpholog2.96075834
8MP0001529_abnormal_vocalization2.85818822
9MP0004264_abnormal_extraembryonic_tissu2.78141158
10MP0003890_abnormal_embryonic-extraembry2.64576087
11MP0003111_abnormal_nucleus_morphology2.45728838
12MP0003077_abnormal_cell_cycle2.44000477
13MP0002254_reproductive_system_inflammat2.39093539
14MP0002396_abnormal_hematopoietic_system2.32828337
15MP0010094_abnormal_chromosome_stability2.31398548
16MP0010030_abnormal_orbit_morphology2.29222537
17MP0001346_abnormal_lacrimal_gland2.25357399
18MP0003122_maternal_imprinting2.13156204
19MP0003693_abnormal_embryo_hatching2.10527357
20MP0005083_abnormal_biliary_tract2.08419024
21MP0003121_genomic_imprinting2.07686833
22MP0008789_abnormal_olfactory_epithelium1.96813103
23MP0001672_abnormal_embryogenesis/_devel1.85698450
24MP0005380_embryogenesis_phenotype1.85698450
25MP0002653_abnormal_ependyma_morphology1.84675301
26MP0000537_abnormal_urethra_morphology1.83056943
27MP0000350_abnormal_cell_proliferation1.79953857
28MP0005451_abnormal_body_composition1.73305769
29MP0003123_paternal_imprinting1.71361738
30MP0009672_abnormal_birth_weight1.70738361
31MP0003938_abnormal_ear_development1.69998046
32MP0003984_embryonic_growth_retardation1.69856629
33MP0002088_abnormal_embryonic_growth/wei1.69852602
34MP0008932_abnormal_embryonic_tissue1.61433637
35MP0004233_abnormal_muscle_weight1.57325251
36MP0001730_embryonic_growth_arrest1.56991662
37MP0010352_gastrointestinal_tract_polyps1.55746507
38MP0001293_anophthalmia1.54094041
39MP0004381_abnormal_hair_follicle1.53543186
40MP0008007_abnormal_cellular_replicative1.53334941
41MP0006035_abnormal_mitochondrial_morpho1.48695888
42MP0000490_abnormal_crypts_of1.45870654
43MP0002085_abnormal_embryonic_tissue1.44990163
44MP0000678_abnormal_parathyroid_gland1.40378794
45MP0000049_abnormal_middle_ear1.40128452
46MP0008058_abnormal_DNA_repair1.39196144
47MP0003942_abnormal_urinary_system1.39101605
48MP0002160_abnormal_reproductive_system1.37924281
49MP0002210_abnormal_sex_determination1.36119263
50MP0005257_abnormal_intraocular_pressure1.35259309
51MP0002332_abnormal_exercise_endurance1.33584734
52MP0002277_abnormal_respiratory_mucosa1.33419163
53MP0003705_abnormal_hypodermis_morpholog1.31769001
54MP0001727_abnormal_embryo_implantation1.30062392
55MP0003718_maternal_effect1.28789757
56MP0002084_abnormal_developmental_patter1.28389689
57MP0003315_abnormal_perineum_morphology1.26992754
58MP0002697_abnormal_eye_size1.26928020
59MP0002932_abnormal_joint_morphology1.26721224
60MP0001348_abnormal_lacrimal_gland1.25110759
61MP0000313_abnormal_cell_death1.24959175
62MP0000358_abnormal_cell_content/1.24614874
63MP0003221_abnormal_cardiomyocyte_apopto1.23635060
64MP0002086_abnormal_extraembryonic_tissu1.23312874
65MP0002092_abnormal_eye_morphology1.22173705
66MP0001697_abnormal_embryo_size1.21781648
67MP0004133_heterotaxia1.20430923
68MP0008995_early_reproductive_senescence1.20179026
69MP0003763_abnormal_thymus_physiology1.19302579
70MP0000703_abnormal_thymus_morphology1.19259236
71MP0002132_abnormal_respiratory_system1.19017855
72MP0004858_abnormal_nervous_system1.18109275
73MP0006082_CNS_inflammation1.17245666
74MP0002080_prenatal_lethality1.16796910
75MP0008260_abnormal_autophagy1.16596302
76MP0005076_abnormal_cell_differentiation1.14635288
77MP0002638_abnormal_pupillary_reflex1.14423444
78MP0003119_abnormal_digestive_system1.12284398
79MP0001849_ear_inflammation1.10870082
80MP0003183_abnormal_peptide_metabolism1.10481682
81MP0002127_abnormal_cardiovascular_syste1.10150752
82MP0002722_abnormal_immune_system1.09181545
83MP0002398_abnormal_bone_marrow1.08890463
84MP0000428_abnormal_craniofacial_morphol1.08777815
85MP0009333_abnormal_splenocyte_physiolog1.08555306
86MP0002751_abnormal_autonomic_nervous1.08204123
87MP0000689_abnormal_spleen_morphology1.07104328
88MP0004197_abnormal_fetal_growth/weight/1.04902905
89MP0001145_abnormal_male_reproductive1.04192004
90MP0000566_synostosis1.04125513
91MP0003115_abnormal_respiratory_system1.02147942
92MP0002249_abnormal_larynx_morphology0.99709490
93MP0001929_abnormal_gametogenesis0.98973091
94MP0002234_abnormal_pharynx_morphology0.97815985
95MP0002114_abnormal_axial_skeleton0.97420637
96MP0003385_abnormal_body_wall0.96119542
97MP0002019_abnormal_tumor_incidence0.95780059
98MP0001270_distended_abdomen0.93437921
99MP0002233_abnormal_nose_morphology0.93431511
100MP0001661_extended_life_span0.93152554
101MP0005501_abnormal_skin_physiology0.92616958
102MP0002429_abnormal_blood_cell0.92307590
103MP0000762_abnormal_tongue_morphology0.91439868
104MP0003935_abnormal_craniofacial_develop0.90141733
105MP0005391_vision/eye_phenotype0.89931093
106MP0003755_abnormal_palate_morphology0.89556827
107MP0008770_decreased_survivor_rate0.89147032
108MP0003786_premature_aging0.88237680
109MP0003943_abnormal_hepatobiliary_system0.87872349
110MP0000432_abnormal_head_morphology0.86853690
111MP0005248_abnormal_Harderian_gland0.84923451
112MP0008961_abnormal_basal_metabolism0.84571418
113MP0002098_abnormal_vibrissa_morphology0.84311899
114MP0005623_abnormal_meninges_morphology0.83758955
115MP0000716_abnormal_immune_system0.82446246
116MP0001800_abnormal_humoral_immune0.81980060
117MP0000653_abnormal_sex_gland0.81956767
118MP0002111_abnormal_tail_morphology0.80257394
119MP0010307_abnormal_tumor_latency0.80202344
120MP0000003_abnormal_adipose_tissue0.79854742
121MP0003567_abnormal_fetal_cardiomyocyte0.78879650
122MP0003861_abnormal_nervous_system0.78327533
123MP0000579_abnormal_nail_morphology0.77396917
124MP0001286_abnormal_eye_development0.76924566
125MP0001188_hyperpigmentation0.76454427
126MP0002161_abnormal_fertility/fecundity0.75983364
127MP0002152_abnormal_brain_morphology0.75682811
128MP0009697_abnormal_copulation0.74845616
129MP0002970_abnormal_white_adipose0.74658631
130MP0003698_abnormal_male_reproductive0.73745900
131MP0003937_abnormal_limbs/digits/tail_de0.71919094
132MP0004811_abnormal_neuron_physiology0.71913467
133MP0002081_perinatal_lethality0.71821870
134MP0000858_altered_metastatic_potential0.70863522
135MP0002938_white_spotting0.70166971
136MP0001986_abnormal_taste_sensitivity0.69989494
137MP0000534_abnormal_ureter_morphology0.69717932
138MP0005671_abnormal_response_to0.69401045
139MP0002405_respiratory_system_inflammati0.68966138
140MP0004808_abnormal_hematopoietic_stem0.68871315
141MP0005645_abnormal_hypothalamus_physiol0.68584292
142MP0003136_yellow_coat_color0.66625603
143MP0002116_abnormal_craniofacial_bone0.66414915
144MP0005266_abnormal_metabolism0.66046646
145MP0009703_decreased_birth_body0.65124009
146MP0002925_abnormal_cardiovascular_devel0.64980076
147MP0003787_abnormal_imprinting0.63912357

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)5.84825706
2Multiple enchondromatosis (HP:0005701)4.65865790
3Hepatoblastoma (HP:0002884)4.47713783
4Hypochromic microcytic anemia (HP:0004840)4.38383891
5Rib fusion (HP:0000902)4.36975943
6Ependymoma (HP:0002888)3.97004349
7Abnormal gallbladder physiology (HP:0012438)3.68903219
8Cholecystitis (HP:0001082)3.68903219
9Broad distal phalanx of finger (HP:0009836)3.52499717
10Neoplasm of striated muscle (HP:0009728)3.49136255
11Trismus (HP:0000211)3.39512013
12Abnormal lung lobation (HP:0002101)3.37841556
13Rhabdomyosarcoma (HP:0002859)3.36633579
14Cortical dysplasia (HP:0002539)3.36169902
15Chromosomal breakage induced by crosslinking agents (HP:0003221)3.30347490
16Nephroblastoma (Wilms tumor) (HP:0002667)3.15862307
17Abnormality of the lower motor neuron (HP:0002366)3.05702336
18Chromsome breakage (HP:0040012)3.03554433
19Embryonal renal neoplasm (HP:0011794)2.94466240
20Partial duplication of thumb phalanx (HP:0009944)2.89769839
21Sensory axonal neuropathy (HP:0003390)2.88731592
22Preauricular skin tag (HP:0000384)2.83358522
23Rectovaginal fistula (HP:0000143)2.75099299
24Rectal fistula (HP:0100590)2.75099299
25Combined immunodeficiency (HP:0005387)2.71144897
26Hand muscle atrophy (HP:0009130)2.70021824
27Partial duplication of the phalanx of hand (HP:0009999)2.67813493
28Meckel diverticulum (HP:0002245)2.66829296
29Aplasia/Hypoplasia of the sacrum (HP:0008517)2.66266168
30Microvesicular hepatic steatosis (HP:0001414)2.63410440
31Hyperacusis (HP:0010780)2.60529853
32Supernumerary spleens (HP:0009799)2.58467543
33Intestinal fistula (HP:0100819)2.57144597
34Cholelithiasis (HP:0001081)2.55773960
35Abnormality of the ileum (HP:0001549)2.53957161
36Skin tags (HP:0010609)2.53859522
37Ragged-red muscle fibers (HP:0003200)2.53431217
38Abnormality of the phalanges of the hallux (HP:0010057)2.52706927
39Anomalous pulmonary venous return (HP:0010772)2.51491208
40Atresia of the external auditory canal (HP:0000413)2.49083231
41Large earlobe (HP:0009748)2.48644704
42Generalized hypotonia (HP:0001290)2.48248312
43Septate vagina (HP:0001153)2.45850483
44Aplastic anemia (HP:0001915)2.45834451
45Amyotrophic lateral sclerosis (HP:0007354)2.45598194
46Bifid tongue (HP:0010297)2.44023875
47Reticulocytopenia (HP:0001896)2.42493521
48Abnormality of the astrocytes (HP:0100707)2.40853775
49Astrocytoma (HP:0009592)2.40853775
50Increased nuchal translucency (HP:0010880)2.40430376
51Fused cervical vertebrae (HP:0002949)2.39845752
52Upper limb amyotrophy (HP:0009129)2.37430915
53Distal upper limb amyotrophy (HP:0007149)2.37430915
54Proximal placement of thumb (HP:0009623)2.37197549
55Testicular atrophy (HP:0000029)2.35716504
56Medulloblastoma (HP:0002885)2.34949503
57Hypochromic anemia (HP:0001931)2.33995083
58Abnormality of the gallbladder (HP:0005264)2.33506239
59Horseshoe kidney (HP:0000085)2.33407787
60Vaginal fistula (HP:0004320)2.32385975
61Impulsivity (HP:0100710)2.31615039
62Facial hemangioma (HP:0000329)2.29757309
63Abnormal gallbladder morphology (HP:0012437)2.28835778
64Increased serum pyruvate (HP:0003542)2.26059927
65Abnormality of glycolysis (HP:0004366)2.26059927
66Aplasia/Hypoplasia of the spleen (HP:0010451)2.23958000
67Reduced antithrombin III activity (HP:0001976)2.23230558
68Aplasia/hypoplasia of the humerus (HP:0006507)2.23182846
69Aplasia/Hypoplasia of the uvula (HP:0010293)2.22201179
70Nasal polyposis (HP:0100582)2.21533515
71Glossoptosis (HP:0000162)2.21386579
72Supernumerary ribs (HP:0005815)2.19786795
73Hypoplasia of the capital femoral epiphysis (HP:0003090)2.19156323
74Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.18998322
75Abnormal protein N-linked glycosylation (HP:0012347)2.18998322
76Abnormal protein glycosylation (HP:0012346)2.18998322
77Abnormal glycosylation (HP:0012345)2.18998322
78Deviation of the thumb (HP:0009603)2.18371583
79Akinesia (HP:0002304)2.17983765
80Abnormality of the pulmonary veins (HP:0011718)2.17973832
81Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.16770317
82Insomnia (HP:0100785)2.15545268
83Hypoplasia of the fovea (HP:0007750)2.14097499
84Aplasia/Hypoplasia of the fovea (HP:0008060)2.14097499
85Supernumerary bones of the axial skeleton (HP:0009144)2.13907740
86Abnormal umbilical cord blood vessels (HP:0011403)2.13855366
87Single umbilical artery (HP:0001195)2.13855366
88Abnormality of the fetal cardiovascular system (HP:0010948)2.13855366
89Type I transferrin isoform profile (HP:0003642)2.13636089
90High anterior hairline (HP:0009890)2.13279379
91Pendular nystagmus (HP:0012043)2.12301281
92Asplenia (HP:0001746)2.10837348
93Renal duplication (HP:0000075)2.09540720
94Microretrognathia (HP:0000308)2.07543003
95Abnormality of the labia minora (HP:0012880)2.06802163
96Abnormality of the salivary glands (HP:0010286)2.06705580
97Preauricular pit (HP:0004467)2.05117574
98Periauricular skin pits (HP:0100277)2.05117574
99Abnormality of cells of the erythroid lineage (HP:0012130)2.04831701
100Aplasia/Hypoplasia of the sternum (HP:0006714)2.04478100
101Myelodysplasia (HP:0002863)2.02865575
102Prominent occiput (HP:0000269)2.02512151
103Abnormality of chromosome segregation (HP:0002916)2.00679375
104Triphalangeal thumb (HP:0001199)2.00386098
105Cleft eyelid (HP:0000625)1.99513298
106Patellar aplasia (HP:0006443)1.98516384
107Concave nail (HP:0001598)1.98299878
108Gout (HP:0001997)1.97897655
109Long palpebral fissure (HP:0000637)1.96499937
110Poor head control (HP:0002421)1.96161900
111Abnormality of the preputium (HP:0100587)1.95938375
112Optic nerve coloboma (HP:0000588)1.95732912
113Abnormality of the heme biosynthetic pathway (HP:0010472)1.95511260
114Trigonocephaly (HP:0000243)1.94852162
115Duodenal stenosis (HP:0100867)1.94000945
116Small intestinal stenosis (HP:0012848)1.94000945
117Cheilitis (HP:0100825)1.93974623
118Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.93660741
119Absent epiphyses (HP:0010577)1.93660741
120Pallor (HP:0000980)1.92914062
1213-Methylglutaconic aciduria (HP:0003535)1.92904211
122Aplasia/Hypoplasia of the brainstem (HP:0007362)1.92386059
123Hypoplasia of the brainstem (HP:0002365)1.92386059
124Nasolacrimal duct obstruction (HP:0000579)1.92246686
125Tongue fasciculations (HP:0001308)1.91909600
126Angiofibromas (HP:0010615)1.91812765
127Adenoma sebaceum (HP:0009720)1.91812765
128Upper limb muscle weakness (HP:0003484)1.90848717
129Retinal dysplasia (HP:0007973)1.90438952
130Overriding aorta (HP:0002623)1.89408845
131Abnormal number of erythroid precursors (HP:0012131)1.89284825
132Abnormality of the umbilical cord (HP:0010881)1.88262455
133Absent radius (HP:0003974)1.88003146
134Short 5th finger (HP:0009237)1.87209902
135Atrophy/Degeneration involving motor neurons (HP:0007373)1.86106469
136Obsessive-compulsive behavior (HP:0000722)1.86104380
137Sloping forehead (HP:0000340)1.85747701
138Duplication of thumb phalanx (HP:0009942)1.85264190
139Premature ovarian failure (HP:0008209)1.84731252
140Progressive external ophthalmoplegia (HP:0000590)1.84556116
141Short humerus (HP:0005792)1.83979665
142Progressive muscle weakness (HP:0003323)1.82457961
143Aplasia/Hypoplasia of the patella (HP:0006498)1.81737454
144Abnormality of the carotid arteries (HP:0005344)1.81572354
145Selective tooth agenesis (HP:0001592)1.81114922
146Abnormal cartilage morphology (HP:0002763)1.80985409
147Aplasia involving forearm bones (HP:0009822)1.80646709
148Absent forearm bone (HP:0003953)1.80646709
149Short thumb (HP:0009778)1.80382565
150Villous atrophy (HP:0011473)1.80382527
151Abnormality of small intestinal villus morphology (HP:0011472)1.80382527
152Progressive hearing impairment (HP:0001730)1.79882902
153Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.79861133
154Abnormality of the nasal mucosa (HP:0000433)1.79656531
155Carpal bone hypoplasia (HP:0001498)1.78045639
156Self-mutilation (HP:0000742)1.77996159
157Congenital glaucoma (HP:0001087)1.77607309
158Large eyes (HP:0001090)1.76564945
159Progressive sensorineural hearing impairment (HP:0000408)1.74804934
160Hyperglycinemia (HP:0002154)1.71955880
161Abnormality of reticulocytes (HP:0004312)1.71571956
162Abnormality of cochlea (HP:0000375)1.68525954
163Reticulocytosis (HP:0001923)1.66626486
164Colon cancer (HP:0003003)1.66528291
165Cerebellar hypoplasia (HP:0001321)1.66452038
166Pointed chin (HP:0000307)1.65239441
167Ectopic kidney (HP:0000086)1.63444086
168Renovascular hypertension (HP:0100817)1.62916102
169Abnormality of alanine metabolism (HP:0010916)1.62793001
170Hyperalaninemia (HP:0003348)1.62793001
171Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.62793001
172Nonimmune hydrops fetalis (HP:0001790)1.61648072
173Postnatal microcephaly (HP:0005484)1.61618848
174Diminished movement (HP:0002374)1.59925851

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK127.15389106
2GRK54.16813139
3GRK64.15953955
4SMG13.10338613
5ERN12.89210069
6STK102.80129681
7CSF1R2.58717767
8TLK12.56789504
9TRIB32.53352525
10VRK22.51936430
11GRK12.48256688
12ADRBK22.34706292
13TRIM282.34410486
14TTK2.18151067
15TGFBR22.08156854
16BUB11.98774150
17GRK71.95168386
18MAP3K101.88506971
19CDK71.86632450
20MAPK71.86227780
21NME11.83183835
22TYRO31.80495274
23CDC71.79688689
24BRSK11.77005164
25BCR1.74420166
26MATK1.73187743
27SRPK11.63369137
28PLK41.53110976
29MAP2K71.48348228
30TESK21.40025967
31NEK11.38298668
32CHEK21.37665230
33LIMK11.37299578
34WEE11.37232469
35PASK1.37026727
36TESK11.32883456
37MARK21.32439291
38PLK11.32210488
39WNK31.31578574
40CDK91.28819929
41MOS1.28699501
42WNK11.26755352
43RPS6KB21.26346174
44STK161.25734778
45MAP4K21.22752061
46PAK41.19294010
47BLK1.17769668
48NEK21.17540359
49IRAK31.14351690
50DYRK31.11868733
51SIK31.10119750
52CAMK41.09787903
53HIPK21.09347656
54CHEK11.01259576
55ADRBK11.00864191
56BRAF0.99836555
57MAP4K10.99472728
58PRKD30.98729910
59CDK190.98364990
60NME20.97382743
61CSK0.91796208
62EIF2AK10.91665021
63BRD40.90231712
64CLK10.88999118
65RPS6KA40.88478428
66AURKA0.87033992
67PRKG20.86816454
68SIK20.85006028
69CSNK1A1L0.83110764
70ITK0.79781838
71CDK40.79455698
72PRPF4B0.76128057
73PKN20.73683777
74PRKD20.73575737
75RAF10.73196229
76LMTK20.72454871
77ALK0.72075374
78MAP3K70.71872121
79FGFR30.67652618
80CDK20.67157924
81KSR20.65494485
82CAMK1D0.64396804
83PLK30.64159084
84MKNK20.63639389
85EIF2AK20.62767515
86CDK180.61839987
87PAK10.61783107
88VRK10.61582885
89DYRK1B0.60166823
90MAP3K40.60067750
91PRKCI0.59784230
92CSNK1G10.59771499
93DYRK20.59573591
94CAMK1G0.59362593
95CDK80.56865781
96MST40.56619458
97MKNK10.56505031
98IKBKB0.55986875
99TSSK60.55523346
100AURKB0.54867481
101TAF10.54331598
102CDK30.54024655
103ATM0.53910631
104KSR10.52561214
105ICK0.52459636
106CSNK1G20.51169636
107ARAF0.50969639
108PDK20.50800756
109STK40.49995781
110PDGFRA0.48815273
111MAPK110.48310870
112ATR0.47721492
113EEF2K0.46090451
114CSNK1E0.44538609
115TAOK20.44525680
116EPHA20.44511870
117CDK10.43185832
118* AKT20.42611085
119ZAP700.42291421
120LCK0.41072324
121MAPK120.40511207
122PBK0.40201650
123MTOR0.40164008
124CSNK2A10.39344894
125UHMK10.39245747
126PNCK0.39137523
127CCNB10.39133750
128MAP3K80.37530991
129BCKDK0.37405238
130PIM10.36960853
131PRKDC0.36651719
132KIT0.35112494
133NTRK10.34932055
134FES0.33969772
135PIM20.33969011
136CDK11A0.33635946
137CSNK1G30.33155179
138YES10.31545410
139MAP2K40.31136821
140MAPK40.31130951
141CDK150.30461477
142SCYL20.29654299
143BRSK20.29323642
144TXK0.29193831
145CDK140.28951310
146SYK0.28686897
147FLT30.26593192
148CSNK2A20.26190268
149TGFBR10.25947845

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.49128450
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.06435642
3Vitamin B6 metabolism_Homo sapiens_hsa007503.48401218
4DNA replication_Homo sapiens_hsa030303.33998271
5Spliceosome_Homo sapiens_hsa030403.10231692
6Mismatch repair_Homo sapiens_hsa034302.98423828
7Homologous recombination_Homo sapiens_hsa034402.64740763
8RNA transport_Homo sapiens_hsa030132.63448255
9RNA polymerase_Homo sapiens_hsa030202.62813911
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.61100513
11Biosynthesis of amino acids_Homo sapiens_hsa012302.34751521
12mRNA surveillance pathway_Homo sapiens_hsa030152.17528583
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.17078501
14Fanconi anemia pathway_Homo sapiens_hsa034602.12025399
15Cell cycle_Homo sapiens_hsa041102.10686793
16One carbon pool by folate_Homo sapiens_hsa006702.09150274
17Base excision repair_Homo sapiens_hsa034102.08518082
18Primary immunodeficiency_Homo sapiens_hsa053402.02105867
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.94023892
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.87567036
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.75869617
22Nucleotide excision repair_Homo sapiens_hsa034201.74243250
23Steroid biosynthesis_Homo sapiens_hsa001001.70363227
24Carbon metabolism_Homo sapiens_hsa012001.65730323
25Sulfur relay system_Homo sapiens_hsa041221.62547333
26Fructose and mannose metabolism_Homo sapiens_hsa000511.59651710
27Proteasome_Homo sapiens_hsa030501.55498409
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.49792068
29Basal transcription factors_Homo sapiens_hsa030221.49252075
30Arachidonic acid metabolism_Homo sapiens_hsa005901.38222446
31Non-homologous end-joining_Homo sapiens_hsa034501.37063296
32Pyrimidine metabolism_Homo sapiens_hsa002401.35802712
33* RNA degradation_Homo sapiens_hsa030181.29691205
34Thyroid cancer_Homo sapiens_hsa052161.27621186
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.25278842
36Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.20131847
37Fatty acid elongation_Homo sapiens_hsa000621.17047889
38Lysine degradation_Homo sapiens_hsa003101.10792413
39Galactose metabolism_Homo sapiens_hsa000521.08230245
40Selenocompound metabolism_Homo sapiens_hsa004501.08041875
41N-Glycan biosynthesis_Homo sapiens_hsa005101.08019480
42Herpes simplex infection_Homo sapiens_hsa051681.07520488
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.07482519
44Transcriptional misregulation in cancer_Homo sapiens_hsa052021.07234544
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.05484524
46Pyruvate metabolism_Homo sapiens_hsa006201.04910382
47Acute myeloid leukemia_Homo sapiens_hsa052210.98327374
48T cell receptor signaling pathway_Homo sapiens_hsa046600.98095700
49p53 signaling pathway_Homo sapiens_hsa041150.96020196
50Basal cell carcinoma_Homo sapiens_hsa052170.95467156
51Linoleic acid metabolism_Homo sapiens_hsa005910.95036262
52Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.94582829
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.94141793
54Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.93397354
55Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.91269733
56Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.90223533
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.88765793
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.86415018
59Vibrio cholerae infection_Homo sapiens_hsa051100.85578882
60Other glycan degradation_Homo sapiens_hsa005110.85160937
61Epstein-Barr virus infection_Homo sapiens_hsa051690.84943777
62Notch signaling pathway_Homo sapiens_hsa043300.84854440
63Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.84794294
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.84190643
65B cell receptor signaling pathway_Homo sapiens_hsa046620.84147426
66Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.83654685
67RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.80600653
68MicroRNAs in cancer_Homo sapiens_hsa052060.79641952
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.77736308
70Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.75325326
71Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.74311698
72HTLV-I infection_Homo sapiens_hsa051660.72843974
73mTOR signaling pathway_Homo sapiens_hsa041500.72828584
74Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.72500837
75Viral carcinogenesis_Homo sapiens_hsa052030.71880064
76Antigen processing and presentation_Homo sapiens_hsa046120.71168451
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.71111588
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70899231
79Pentose phosphate pathway_Homo sapiens_hsa000300.68684476
80Huntingtons disease_Homo sapiens_hsa050160.64535157
81Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.64400751
82Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64365063
83Pathways in cancer_Homo sapiens_hsa052000.62892895
84Phototransduction_Homo sapiens_hsa047440.62822167
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.62405885
86Arginine and proline metabolism_Homo sapiens_hsa003300.61943114
87Hematopoietic cell lineage_Homo sapiens_hsa046400.60109638
88NF-kappa B signaling pathway_Homo sapiens_hsa040640.56975685
89Sulfur metabolism_Homo sapiens_hsa009200.54299536
90Hedgehog signaling pathway_Homo sapiens_hsa043400.53451511
91Intestinal immune network for IgA production_Homo sapiens_hsa046720.53343040
92Colorectal cancer_Homo sapiens_hsa052100.51972074
93Wnt signaling pathway_Homo sapiens_hsa043100.51199010
94Metabolic pathways_Homo sapiens_hsa011000.50184685
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49817678
96Apoptosis_Homo sapiens_hsa042100.49084280
97Oocyte meiosis_Homo sapiens_hsa041140.48797576
98Cyanoamino acid metabolism_Homo sapiens_hsa004600.48509717
99Ether lipid metabolism_Homo sapiens_hsa005650.46862363
100Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.45763909
101Bladder cancer_Homo sapiens_hsa052190.45559859
102Phospholipase D signaling pathway_Homo sapiens_hsa040720.45350611
103Arginine biosynthesis_Homo sapiens_hsa002200.45320237
104Propanoate metabolism_Homo sapiens_hsa006400.45204195
105Glutathione metabolism_Homo sapiens_hsa004800.45050553
106Purine metabolism_Homo sapiens_hsa002300.44199892
107Fatty acid metabolism_Homo sapiens_hsa012120.43934447
108Sphingolipid metabolism_Homo sapiens_hsa006000.43876651
109Parkinsons disease_Homo sapiens_hsa050120.43548312
110Regulation of autophagy_Homo sapiens_hsa041400.43416692
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.43091158
112Hippo signaling pathway_Homo sapiens_hsa043900.42492637
113Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.42302169
114Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42200579
115Non-small cell lung cancer_Homo sapiens_hsa052230.41958112
116Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.41624506
117Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41435499
118Endometrial cancer_Homo sapiens_hsa052130.40790130
119Pancreatic cancer_Homo sapiens_hsa052120.38575487
120Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37747649
121Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37687285
122Protein export_Homo sapiens_hsa030600.37329623
123Leukocyte transendothelial migration_Homo sapiens_hsa046700.37139177
124Folate biosynthesis_Homo sapiens_hsa007900.36655989
125Adherens junction_Homo sapiens_hsa045200.36605627
126Measles_Homo sapiens_hsa051620.35670467
127Central carbon metabolism in cancer_Homo sapiens_hsa052300.34629378
128Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33505873
129AMPK signaling pathway_Homo sapiens_hsa041520.32552876
130VEGF signaling pathway_Homo sapiens_hsa043700.32040754
131Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.31883782
132Axon guidance_Homo sapiens_hsa043600.31851988
133Chronic myeloid leukemia_Homo sapiens_hsa052200.29665846
134Shigellosis_Homo sapiens_hsa051310.29569789
135Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.29139858
136Insulin signaling pathway_Homo sapiens_hsa049100.28920165
137Jak-STAT signaling pathway_Homo sapiens_hsa046300.28064411
138PI3K-Akt signaling pathway_Homo sapiens_hsa041510.28059430
139Vitamin digestion and absorption_Homo sapiens_hsa049770.26803781
140Inositol phosphate metabolism_Homo sapiens_hsa005620.26724378
141Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26611697
142Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.25855811
143Neurotrophin signaling pathway_Homo sapiens_hsa047220.25466387
144Choline metabolism in cancer_Homo sapiens_hsa052310.24177690
145TGF-beta signaling pathway_Homo sapiens_hsa043500.22418382
146Rap1 signaling pathway_Homo sapiens_hsa040150.22161623
147Long-term depression_Homo sapiens_hsa047300.21867164
148Hepatitis B_Homo sapiens_hsa051610.21831340

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