EDC4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)4.79304765
2nuclear pore organization (GO:0006999)4.72289992
3positive regulation of protein sumoylation (GO:0033235)4.67066772
4pre-miRNA processing (GO:0031054)4.61722066
5negative regulation of erythrocyte differentiation (GO:0045647)4.60175658
6protein localization to kinetochore (GO:0034501)4.53983831
7regulation of T-helper 2 cell differentiation (GO:0045628)4.49004717
8tooth mineralization (GO:0034505)4.44749671
9negative regulation of histone methylation (GO:0031061)4.34676791
10mitotic chromosome condensation (GO:0007076)4.27885070
11heterochromatin organization (GO:0070828)4.17248660
12mitotic nuclear envelope disassembly (GO:0007077)4.14600708
13activation of protein kinase A activity (GO:0034199)4.04357916
14nuclear envelope disassembly (GO:0051081)3.96017759
15membrane disassembly (GO:0030397)3.96017759
16DNA unwinding involved in DNA replication (GO:0006268)3.95061995
17regulation of translational fidelity (GO:0006450)3.94492002
18mitotic sister chromatid segregation (GO:0000070)3.90578460
19negative regulation of type 2 immune response (GO:0002829)3.84055327
20histone H2A monoubiquitination (GO:0035518)3.83977596
21cytoskeletal anchoring at plasma membrane (GO:0007016)3.82721536
22sister chromatid segregation (GO:0000819)3.79496543
23protein localization to chromosome, centromeric region (GO:0071459)3.78666125
24regulation of translational termination (GO:0006449)3.68737503
25peptidyl-lysine dimethylation (GO:0018027)3.67110937
26thymic T cell selection (GO:0045061)3.66984711
27Golgi transport vesicle coating (GO:0048200)3.66832061
28COPI coating of Golgi vesicle (GO:0048205)3.66832061
29mannose metabolic process (GO:0006013)3.55254571
30negative regulation of T-helper cell differentiation (GO:0045623)3.55219308
31negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.55219308
32regulation of T-helper 1 cell differentiation (GO:0045625)3.54968784
33regulation of mitotic spindle organization (GO:0060236)3.53604253
34regulation of histone H3-K9 methylation (GO:0051570)3.49197044
35pore complex assembly (GO:0046931)3.46638636
36DNA replication-dependent nucleosome assembly (GO:0006335)3.44490261
37DNA replication-dependent nucleosome organization (GO:0034723)3.44490261
38regulation of NFAT protein import into nucleus (GO:0051532)3.44312116
39regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.43104261
40spliceosomal tri-snRNP complex assembly (GO:0000244)3.39887990
41apoptotic process involved in morphogenesis (GO:0060561)3.39768355
42regulation of spindle organization (GO:0090224)3.38280688
43regulation of gene silencing by miRNA (GO:0060964)3.37534531
44regulation of gene silencing by RNA (GO:0060966)3.37534531
45regulation of posttranscriptional gene silencing (GO:0060147)3.37534531
46gene silencing by RNA (GO:0031047)3.36092049
47IMP biosynthetic process (GO:0006188)3.35491560
48folic acid-containing compound biosynthetic process (GO:0009396)3.34981731
49DNA duplex unwinding (GO:0032508)3.34886578
50cAMP biosynthetic process (GO:0006171)3.34623408
51DNA geometric change (GO:0032392)3.33647093
52regulation of mammary gland epithelial cell proliferation (GO:0033599)3.31492556
53regulation of histone H3-K27 methylation (GO:0061085)3.29789982
543-UTR-mediated mRNA stabilization (GO:0070935)3.28183927
55cell-substrate adherens junction assembly (GO:0007045)3.26194058
56focal adhesion assembly (GO:0048041)3.26194058
57positive regulation of chromosome segregation (GO:0051984)3.24611917
58positive thymic T cell selection (GO:0045059)3.24579138
59nuclear envelope organization (GO:0006998)3.24061125
60intracellular estrogen receptor signaling pathway (GO:0030520)3.23996213
61adherens junction assembly (GO:0034333)3.23712624
62chromatin assembly (GO:0031497)3.23532757
63dosage compensation (GO:0007549)3.20400399
64gene silencing (GO:0016458)3.18530972
65regulation of sister chromatid cohesion (GO:0007063)3.18057415
66regulation of protein sumoylation (GO:0033233)3.17725717
67proline biosynthetic process (GO:0006561)3.17718490
68mitotic metaphase plate congression (GO:0007080)3.14144283
69NLS-bearing protein import into nucleus (GO:0006607)3.11303788
70peptidyl-arginine omega-N-methylation (GO:0035247)3.09627699
71activation of Rac GTPase activity (GO:0032863)3.08702470
72positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.06873161
73positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.06873161
74positive regulation of mitotic sister chromatid separation (GO:1901970)3.06873161
75negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.06036255
76protein localization to chromosome (GO:0034502)3.05853702
77regulation of hippo signaling (GO:0035330)3.03448726
78hyaluronan catabolic process (GO:0030214)3.01835612
79glucocorticoid receptor signaling pathway (GO:0042921)3.01316799
80negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.99838684
81mitotic sister chromatid cohesion (GO:0007064)2.99436448
82translesion synthesis (GO:0019985)2.98418877
83chromosome condensation (GO:0030261)2.97744476
84histone H3-K36 demethylation (GO:0070544)2.96277397
85regulation of chromatin binding (GO:0035561)2.94962525
86IMP metabolic process (GO:0046040)2.89242810
87regulation of RNA export from nucleus (GO:0046831)2.88240823
88retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.87390897
89histone H4-K8 acetylation (GO:0043982)2.85611221
90histone H4-K5 acetylation (GO:0043981)2.85611221
91histone H4 deacetylation (GO:0070933)2.84572266
92response to muramyl dipeptide (GO:0032495)2.84203776
93protein-DNA complex disassembly (GO:0032986)2.83984019
94nucleosome disassembly (GO:0006337)2.83984019
95negative regulation of histone modification (GO:0031057)2.83851065
96protein localization to endosome (GO:0036010)2.83052447
97detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.82150197
98paraxial mesoderm development (GO:0048339)2.81959330
99response to laminar fluid shear stress (GO:0034616)2.80269965
100cellular response to epidermal growth factor stimulus (GO:0071364)2.79607629
101mRNA transport (GO:0051028)2.78207585
102DNA conformation change (GO:0071103)2.78175005
103regulation of chromosome segregation (GO:0051983)2.77138279
104activation of MAPKKK activity (GO:0000185)2.76663676
105positive regulation of SMAD protein import into nucleus (GO:0060391)2.75623650
106embryonic process involved in female pregnancy (GO:0060136)2.73264876
107DNA replication initiation (GO:0006270)2.73018677
108regulation of nucleobase-containing compound transport (GO:0032239)2.72769986
109histone H2A ubiquitination (GO:0033522)2.71333400
110metaphase plate congression (GO:0051310)2.71312880
111mitochondrial fusion (GO:0008053)2.71034944
112epithelial cell differentiation involved in prostate gland development (GO:0060742)2.69902336
113T cell selection (GO:0045058)2.69396688
114peptidyl-arginine N-methylation (GO:0035246)2.68796225
115peptidyl-arginine methylation (GO:0018216)2.68796225
116histone H2A acetylation (GO:0043968)2.68376456
117RNA stabilization (GO:0043489)2.67085654
118mRNA stabilization (GO:0048255)2.67085654
119regulation of centriole replication (GO:0046599)2.66711371
120chromatin assembly or disassembly (GO:0006333)2.66692401
121cell-substrate junction assembly (GO:0007044)2.66367843
122negative regulation of chromatin modification (GO:1903309)2.65450826
123formation of translation preinitiation complex (GO:0001731)2.65415983
124spindle assembly involved in mitosis (GO:0090307)2.65319934
125synaptonemal complex assembly (GO:0007130)2.64175330
126regulation of ARF GTPase activity (GO:0032312)2.63909015
127chromatin silencing (GO:0006342)2.63579799
128maternal placenta development (GO:0001893)2.62934886
129regulation of telomere maintenance via telomerase (GO:0032210)2.62832797
130regulation of early endosome to late endosome transport (GO:2000641)2.62063603
131positive regulation of gene expression, epigenetic (GO:0045815)2.62038291
132DNA packaging (GO:0006323)2.61543790
133modulation by symbiont of host cellular process (GO:0044068)2.60745475
134NIK/NF-kappaB signaling (GO:0038061)2.59971562
135histone arginine methylation (GO:0034969)2.59189664
136snRNA metabolic process (GO:0016073)2.59081023
137positive regulation of RNA splicing (GO:0033120)2.58996840
138regulation of glucose import in response to insulin stimulus (GO:2001273)2.58380798
139piRNA metabolic process (GO:0034587)2.58074438
140hepatocyte apoptotic process (GO:0097284)2.57715495
141negative regulation of chromosome segregation (GO:0051985)2.57062794
142negative regulation of cell size (GO:0045792)2.57015372
143postreplication repair (GO:0006301)2.56224515
144spindle organization (GO:0007051)2.55926569
145corticosteroid receptor signaling pathway (GO:0031958)2.55702271
146modulation by virus of host process (GO:0019054)2.55390337
147nucleic acid transport (GO:0050657)2.55301712
148RNA transport (GO:0050658)2.55301712
149establishment of RNA localization (GO:0051236)2.55301712
150attachment of spindle microtubules to kinetochore (GO:0008608)2.54926507
151negative regulation of RNA splicing (GO:0033119)2.52962737
152positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.52428033
153positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.52286819
154positive regulation of Cdc42 GTPase activity (GO:0043089)2.50603733
155endothelial cell differentiation (GO:0045446)2.45985223
156activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.45090496
157negative regulation of viral release from host cell (GO:1902187)2.44388277
158protein export from nucleus (GO:0006611)2.44274270
159pinocytosis (GO:0006907)2.43636545
160regulation of type I interferon-mediated signaling pathway (GO:0060338)2.43274849
161histone lysine demethylation (GO:0070076)2.42715054
162stress granule assembly (GO:0034063)2.41877724
163positive regulation of nuclease activity (GO:0032075)2.41289121
164protein retention in ER lumen (GO:0006621)2.39987848
165response to epidermal growth factor (GO:0070849)2.39856614
166histone H3 deacetylation (GO:0070932)2.39663135
167planar cell polarity pathway involved in neural tube closure (GO:0090179)2.38404481
168pentose-phosphate shunt (GO:0006098)2.37589512
169stress fiber assembly (GO:0043149)2.37211805
170cellular response to interleukin-4 (GO:0071353)2.36904502
171positive regulation of gamma-delta T cell activation (GO:0046645)2.34367307
172positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.34127114
173negative regulation of myotube differentiation (GO:0010832)2.33129153
174histone demethylation (GO:0016577)2.33064792

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.43695876
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.33285777
3* MYC_22102868_ChIP-Seq_BL_Human3.50968586
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.19863610
5E2F4_17652178_ChIP-ChIP_JURKAT_Human2.85919341
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.73816703
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.64355691
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.52911198
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.52863971
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.52222256
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.39064605
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.36872978
13THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.15569050
14CIITA_25753668_ChIP-Seq_RAJI_Human2.14385640
15NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.13178259
16KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.09264099
17SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.89909929
18CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.88133398
19ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.84727132
20VDR_21846776_ChIP-Seq_THP-1_Human1.84570160
21RARG_19884340_ChIP-ChIP_MEFs_Mouse1.80156151
22KDM2B_26808549_Chip-Seq_DND41_Human1.79751250
23POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.79254886
24TCF7_22412390_ChIP-Seq_EML_Mouse1.76909498
25MYC_19030024_ChIP-ChIP_MESCs_Mouse1.74928065
26TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74714507
27E2F1_21310950_ChIP-Seq_MCF-7_Human1.74116158
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.72271360
29AR_21909140_ChIP-Seq_LNCAP_Human1.70089736
30STAT6_21828071_ChIP-Seq_BEAS2B_Human1.68360909
31KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.68049255
32ZFP281_18757296_ChIP-ChIP_E14_Mouse1.67785669
33NELFA_20434984_ChIP-Seq_ESCs_Mouse1.66797037
34VDR_24763502_ChIP-Seq_THP-1_Human1.66421616
35* XRN2_22483619_ChIP-Seq_HELA_Human1.66261045
36KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.59722436
37CTCF_27219007_Chip-Seq_ERYTHROID_Human1.59455229
38CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.58211005
39MAF_26560356_Chip-Seq_TH2_Human1.57939163
40* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.54180459
41KDM2B_26808549_Chip-Seq_SUP-B15_Human1.53751550
42MYCN_18555785_ChIP-Seq_MESCs_Mouse1.53145166
43NANOG_18555785_ChIP-Seq_MESCs_Mouse1.52312578
44KLF4_18555785_ChIP-Seq_MESCs_Mouse1.51492092
45ZFP281_27345836_Chip-Seq_ESCs_Mouse1.50394858
46SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.49273960
47* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.47565682
48ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.46309607
49KDM5A_27292631_Chip-Seq_BREAST_Human1.45275029
50PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.45134530
51POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.43246486
52ELK3_25401928_ChIP-Seq_HUVEC_Human1.42500149
53STAT3_1855785_ChIP-Seq_MESCs_Mouse1.41998019
54TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.41952982
55CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.41851147
56* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.40366298
57SA1_27219007_Chip-Seq_ERYTHROID_Human1.39758051
58CREB1_26743006_Chip-Seq_LNCaP_Human1.38059303
59* TET1_21451524_ChIP-Seq_MESCs_Mouse1.37060737
60CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.36770808
61TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.36606089
62RUNX1_22412390_ChIP-Seq_EML_Mouse1.35948685
63SALL1_21062744_ChIP-ChIP_HESCs_Human1.35905092
64UTX_26944678_Chip-Seq_JUKART_Human1.35745672
65MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.35362488
66NANOG_21062744_ChIP-ChIP_HESCs_Human1.34599052
67KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.33666876
68ESR2_21235772_ChIP-Seq_MCF-7_Human1.33609428
69KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.30134919
70BRD4_27068464_Chip-Seq_AML-cells_Mouse1.29365942
71UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.29286797
72SMC4_20622854_ChIP-Seq_HELA_Human1.26520426
73CLOCK_20551151_ChIP-Seq_293T_Human1.26511285
74NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.25356145
75YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23624087
76* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.23273918
77TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.22984860
78ZNF263_19887448_ChIP-Seq_K562_Human1.22143205
79DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.21881549
80GATA1_22383799_ChIP-Seq_G1ME_Mouse1.21332443
81ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.20632663
82SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.19820881
83MAF_26560356_Chip-Seq_TH1_Human1.18482387
84WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.15979215
85ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.15684053
86MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.15070250
87PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14424587
88ETS1_20019798_ChIP-Seq_JURKAT_Human1.14070006
89ATF3_27146783_Chip-Seq_COLON_Human1.13882607
90SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13383211
91THAP11_20581084_ChIP-Seq_MESCs_Mouse1.13317308
92KDM2B_26808549_Chip-Seq_JURKAT_Human1.13155838
93CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.12945327
94ERG_21242973_ChIP-ChIP_JURKAT_Human1.12741315
95GATA1_19941827_ChIP-Seq_MEL_Mouse1.12158288
96* GABP_19822575_ChIP-Seq_HepG2_Human1.11733210
97DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.10241943
98TP53_22127205_ChIP-Seq_IMR90_Human1.10016601
99ELF1_20517297_ChIP-Seq_JURKAT_Human1.09948002
100RUNX1_27514584_Chip-Seq_MCF-7_Human1.09875843
101* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.09211861
102HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.08825250
103SRY_22984422_ChIP-ChIP_TESTIS_Rat1.08045868
104* LXR_22292898_ChIP-Seq_THP-1_Human1.07159598
105GATA1_19941826_ChIP-Seq_K562_Human1.07095682
106GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07015341
107SOX2_18555785_ChIP-Seq_MESCs_Mouse1.06888232
108* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.05653619
109TFEB_21752829_ChIP-Seq_HELA_Human1.05372251
110* P68_20966046_ChIP-Seq_HELA_Human1.04955938
111KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.04805947
112NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.04778702
113NCOR1_26117541_ChIP-Seq_K562_Human1.04317734
114STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.04312184
115* TTF2_22483619_ChIP-Seq_HELA_Human1.03256721
116TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02914763
117ESR1_15608294_ChIP-ChIP_MCF-7_Human1.02437545
118RACK7_27058665_Chip-Seq_MCF-7_Human1.02395586
119P300_27058665_Chip-Seq_ZR-75-30cells_Human1.01404146
120NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.00842608
121TP63_19390658_ChIP-ChIP_HaCaT_Human1.00612582
122HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.00451434
123SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.00297241
124NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.99572865
125CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99566324
126STAT4_19710469_ChIP-ChIP_TH1__Mouse0.99544177
127* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.97934213
128NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.97622106
129* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97530494
130CHD1_26751641_Chip-Seq_LNCaP_Human0.97045062
131* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.96840695
132PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96497548
133E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.96297239
134* CTCF_21964334_ChIP-Seq_BJAB-B_Human0.95637626
135GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.95210591
136RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.95119030
137HIF1A_21447827_ChIP-Seq_MCF-7_Human0.94933230
138RBPJ_22232070_ChIP-Seq_NCS_Mouse0.94771200
139RARA_24833708_ChIP-Seq_LIVER_Mouse0.94501378
140FOXP3_21729870_ChIP-Seq_TREG_Human0.93352625
141ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.92844528
142PKCTHETA_26484144_Chip-Seq_BREAST_Human0.92487544
143KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.92300611
144KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.92300611
145KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.92300611
146KDM2B_26808549_Chip-Seq_K562_Human0.92158727
147POU5F1_16518401_ChIP-PET_MESCs_Mouse0.91331631

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003111_abnormal_nucleus_morphology3.49749181
2MP0010352_gastrointestinal_tract_polyps3.43606205
3MP0003705_abnormal_hypodermis_morpholog3.20056789
4MP0005451_abnormal_body_composition3.12226322
5MP0010094_abnormal_chromosome_stability3.11354197
6MP0003693_abnormal_embryo_hatching3.05602640
7MP0003077_abnormal_cell_cycle3.01502350
8MP0002653_abnormal_ependyma_morphology2.97178344
9MP0004957_abnormal_blastocyst_morpholog2.94658677
10MP0005076_abnormal_cell_differentiation2.65366992
11MP0001730_embryonic_growth_arrest2.53668414
12MP0005058_abnormal_lysosome_morphology2.45021797
13MP0008877_abnormal_DNA_methylation2.30557276
14MP0010307_abnormal_tumor_latency2.26914474
15MP0003436_decreased_susceptibility_to2.25763622
16MP0003303_peritoneal_inflammation2.22553639
17MP0003123_paternal_imprinting2.19277975
18MP0000350_abnormal_cell_proliferation2.17288365
19MP0008260_abnormal_autophagy2.15563911
20MP0008007_abnormal_cellular_replicative2.05179320
21MP0002877_abnormal_melanocyte_morpholog2.00803369
22MP0010234_abnormal_vibrissa_follicle1.96255452
23MP0001672_abnormal_embryogenesis/_devel1.95236445
24MP0005380_embryogenesis_phenotype1.95236445
25MP0002084_abnormal_developmental_patter1.91704945
26MP0004233_abnormal_muscle_weight1.90078570
27MP0008057_abnormal_DNA_replication1.84317773
28MP0004197_abnormal_fetal_growth/weight/1.83634642
29MP0002085_abnormal_embryonic_tissue1.81093362
30MP0008961_abnormal_basal_metabolism1.80376195
31MP0003566_abnormal_cell_adhesion1.79760302
32MP0001697_abnormal_embryo_size1.79093464
33MP0003984_embryonic_growth_retardation1.78076470
34MP0004947_skin_inflammation1.76555102
35MP0002088_abnormal_embryonic_growth/wei1.75911532
36MP0003119_abnormal_digestive_system1.72673141
37MP0001849_ear_inflammation1.69166538
38MP0002080_prenatal_lethality1.66547720
39MP0001348_abnormal_lacrimal_gland1.63815432
40MP0002086_abnormal_extraembryonic_tissu1.63745677
41MP0003121_genomic_imprinting1.61667533
42MP0004808_abnormal_hematopoietic_stem1.58452862
43MP0008058_abnormal_DNA_repair1.56702475
44MP0003283_abnormal_digestive_organ1.56007501
45MP0009278_abnormal_bone_marrow1.54995423
46MP0004858_abnormal_nervous_system1.52977945
47MP0009840_abnormal_foam_cell1.52752062
48MP0003329_amyloid_beta_deposits1.51799055
49MP0005623_abnormal_meninges_morphology1.51505572
50MP0009333_abnormal_splenocyte_physiolog1.50756533
51MP0000678_abnormal_parathyroid_gland1.47918759
52MP0002396_abnormal_hematopoietic_system1.47664437
53MP0003453_abnormal_keratinocyte_physiol1.46338737
54MP0000733_abnormal_muscle_development1.45571198
55MP0001915_intracranial_hemorrhage1.45552012
56MP0000858_altered_metastatic_potential1.43407473
57MP0005023_abnormal_wound_healing1.41753612
58MP0003172_abnormal_lysosome_physiology1.41493116
59MP0008932_abnormal_embryonic_tissue1.40171126
60MP0000537_abnormal_urethra_morphology1.36981781
61MP0003115_abnormal_respiratory_system1.31126957
62MP0005084_abnormal_gallbladder_morpholo1.28761822
63MP0005409_darkened_coat_color1.27530363
64MP0001873_stomach_inflammation1.25313401
65MP0010030_abnormal_orbit_morphology1.24467903
66MP0004272_abnormal_basement_membrane1.22946113
67MP0004130_abnormal_muscle_cell1.22437306
68MP0005666_abnormal_adipose_tissue1.22106659
69MP0002249_abnormal_larynx_morphology1.20345389
70MP0000313_abnormal_cell_death1.18034091
71MP0009672_abnormal_birth_weight1.17274419
72MP0000703_abnormal_thymus_morphology1.16191146
73MP0000428_abnormal_craniofacial_morphol1.15630422
74MP0008438_abnormal_cutaneous_collagen1.15463977
75MP0003191_abnormal_cellular_cholesterol1.15440240
76MP0000759_abnormal_skeletal_muscle1.13854299
77MP0003763_abnormal_thymus_physiology1.11152133
78MP0002925_abnormal_cardiovascular_devel1.10931645
79MP0002269_muscular_atrophy1.09173899
80MP0002210_abnormal_sex_determination1.08375331
81MP0001929_abnormal_gametogenesis1.08086891
82MP0002019_abnormal_tumor_incidence1.07972643
83MP0002089_abnormal_postnatal_growth/wei1.07877439
84MP0004084_abnormal_cardiac_muscle1.06472256
85MP0002429_abnormal_blood_cell1.05041931
86MP0000685_abnormal_immune_system1.04120328
87MP0003787_abnormal_imprinting1.03992120
88MP0005000_abnormal_immune_tolerance1.03522775
89MP0001800_abnormal_humoral_immune1.01024883
90MP0009703_decreased_birth_body1.00566036
91MP0002405_respiratory_system_inflammati1.00507778
92MP0002796_impaired_skin_barrier1.00456680
93MP0000747_muscle_weakness1.00247102
94MP0005621_abnormal_cell_physiology0.98773470
95MP0000716_abnormal_immune_system0.98725790
96MP0003091_abnormal_cell_migration0.98606661
97MP0008770_decreased_survivor_rate0.98354771
98MP0003861_abnormal_nervous_system0.98275051
99MP0009931_abnormal_skin_appearance0.97446373
100MP0001270_distended_abdomen0.96423780
101MP0002420_abnormal_adaptive_immunity0.96392228
102MP0000003_abnormal_adipose_tissue0.96287229
103MP0005387_immune_system_phenotype0.96251285
104MP0001790_abnormal_immune_system0.96251285
105MP0001819_abnormal_immune_cell0.95717192
106MP0005501_abnormal_skin_physiology0.95522361
107MP0002009_preneoplasia0.95480169
108MP0002998_abnormal_bone_remodeling0.94859359
109MP0010630_abnormal_cardiac_muscle0.93191909
110MP0001145_abnormal_male_reproductive0.92912160
111MP0001545_abnormal_hematopoietic_system0.92316608
112MP0005397_hematopoietic_system_phenotyp0.92316608
113MP0000266_abnormal_heart_morphology0.92131583
114MP0004381_abnormal_hair_follicle0.91976850
115MP0002419_abnormal_innate_immunity0.91758009
116MP0001958_emphysema0.91401247
117MP0000569_abnormal_digit_pigmentation0.91318053
118MP0005384_cellular_phenotype0.90841504
119MP0005025_abnormal_response_to0.89661843
120MP0010155_abnormal_intestine_physiology0.88610380
121MP0003890_abnormal_embryonic-extraembry0.88583332
122MP0001835_abnormal_antigen_presentation0.86754781
123MP0004087_abnormal_muscle_fiber0.86462684
124MP0003786_premature_aging0.84994681
125MP0001851_eye_inflammation0.83539512
126MP0000653_abnormal_sex_gland0.83232448
127MP0000750_abnormal_muscle_regeneration0.82572102
128MP0005187_abnormal_penis_morphology0.82285415
129MP0002723_abnormal_immune_serum0.82092258
130MP0002111_abnormal_tail_morphology0.81603265
131MP0002452_abnormal_antigen_presenting0.80895160
132MP0003935_abnormal_craniofacial_develop0.80805414
133MP0000465_gastrointestinal_hemorrhage0.80663517
134MP0000689_abnormal_spleen_morphology0.79671315
135MP0002234_abnormal_pharynx_morphology0.79175046
136MP0004185_abnormal_adipocyte_glucose0.79128844
137MP0000477_abnormal_intestine_morphology0.79061979
138MP0003300_gastrointestinal_ulcer0.78331742
139MP0004264_abnormal_extraembryonic_tissu0.78119969
140MP0004133_heterotaxia0.77678098
141MP0001293_anophthalmia0.74194158
142MP0000490_abnormal_crypts_of0.72446518
143MP0000751_myopathy0.72267117
144MP0002161_abnormal_fertility/fecundity0.71954232
145MP0000358_abnormal_cell_content/0.71881862
146MP0003698_abnormal_male_reproductive0.71838110
147MP0003567_abnormal_fetal_cardiomyocyte0.71605043
148MP0003279_aneurysm0.68289140
149MP0002398_abnormal_bone_marrow0.67237436
150MP0002092_abnormal_eye_morphology0.65954437
151MP0002722_abnormal_immune_system0.64817703
152MP0003699_abnormal_female_reproductive0.63792949
153MP0005375_adipose_tissue_phenotype0.63398119
154MP0001784_abnormal_fluid_regulation0.60973257

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)3.65384073
2Abnormality of the lower motor neuron (HP:0002366)3.50429615
3Hyperacusis (HP:0010780)3.38553607
4Cerebral aneurysm (HP:0004944)3.25031576
5Astrocytoma (HP:0009592)2.98055921
6Abnormality of the astrocytes (HP:0100707)2.98055921
7Selective tooth agenesis (HP:0001592)2.95888932
8Increased nuchal translucency (HP:0010880)2.88526588
9Increased connective tissue (HP:0009025)2.87789247
10Hand muscle atrophy (HP:0009130)2.84982330
11Broad face (HP:0000283)2.73639685
12Distal upper limb amyotrophy (HP:0007149)2.73497267
13Upper limb amyotrophy (HP:0009129)2.73497267
14Short 4th metacarpal (HP:0010044)2.68918042
15Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.68918042
16Shallow orbits (HP:0000586)2.61173398
17Long palpebral fissure (HP:0000637)2.61163343
18Colitis (HP:0002583)2.56549509
19Overgrowth (HP:0001548)2.55367312
20Heterotopia (HP:0002282)2.53620055
21Medulloblastoma (HP:0002885)2.53082635
22Elfin facies (HP:0004428)2.49051639
23Renal duplication (HP:0000075)2.47795166
24Centrally nucleated skeletal muscle fibers (HP:0003687)2.47503541
25Distal lower limb amyotrophy (HP:0008944)2.45836741
26Ankle contracture (HP:0006466)2.45618495
27Bowel diverticulosis (HP:0005222)2.45405933
28Disproportionate tall stature (HP:0001519)2.44624178
29Renovascular hypertension (HP:0100817)2.43622272
30Thin bony cortex (HP:0002753)2.41368097
31Abnormal gallbladder physiology (HP:0012438)2.37865964
32Cholecystitis (HP:0001082)2.37865964
33Deviation of the thumb (HP:0009603)2.36121787
34Pointed chin (HP:0000307)2.34254501
35Achilles tendon contracture (HP:0001771)2.32705456
36Obstructive sleep apnea (HP:0002870)2.31349748
37Basal cell carcinoma (HP:0002671)2.30769047
38Protrusio acetabuli (HP:0003179)2.29050679
39Proximal placement of thumb (HP:0009623)2.28944306
40Glioma (HP:0009733)2.27591055
41Spinal muscular atrophy (HP:0007269)2.27056023
42Spinal cord lesions (HP:0100561)2.25330765
43Syringomyelia (HP:0003396)2.25330765
44High pitched voice (HP:0001620)2.24673650
45Cellulitis (HP:0100658)2.23560230
46Insomnia (HP:0100785)2.21889091
47Eczematoid dermatitis (HP:0000976)2.18577866
48Missing ribs (HP:0000921)2.15606536
49Trigonocephaly (HP:0000243)2.12853175
50Flat acetabular roof (HP:0003180)2.12776810
51Neoplasm of the oral cavity (HP:0100649)2.12670730
52Abnormality of the labia minora (HP:0012880)2.12326360
53Premature rupture of membranes (HP:0001788)2.09405493
54Abnormal number of incisors (HP:0011064)2.09385881
55Pseudobulbar signs (HP:0002200)2.08731289
56Asymmetry of the thorax (HP:0001555)2.08399171
57Abnormality of the thoracic spine (HP:0100711)2.07409089
58Bladder diverticulum (HP:0000015)2.07219487
59Difficulty climbing stairs (HP:0003551)2.06910723
60Overriding aorta (HP:0002623)2.05879470
61Myopathic facies (HP:0002058)2.05042958
62Abnormality of the calcaneus (HP:0008364)2.04816353
63Abnormality of the Achilles tendon (HP:0005109)2.04458461
64Hemorrhage of the eye (HP:0011885)2.03217376
65Gastrointestinal inflammation (HP:0004386)2.01692335
66Prominent nose (HP:0000448)2.01645841
67Abnormality of the fingertips (HP:0001211)2.00540287
68Abnormality of the 4th metacarpal (HP:0010012)2.00402396
69Reticulocytosis (HP:0001923)2.00344167
70Genu recurvatum (HP:0002816)1.99411856
71Vertebral arch anomaly (HP:0008438)1.99005685
72Skull defect (HP:0001362)1.96986780
73Thin ribs (HP:0000883)1.96671295
74Broad distal phalanx of finger (HP:0009836)1.96384660
75Ragged-red muscle fibers (HP:0003200)1.96099891
76Sandal gap (HP:0001852)1.94262758
77Stridor (HP:0010307)1.94222540
78Neoplasm of striated muscle (HP:0009728)1.91455140
79Sparse lateral eyebrow (HP:0005338)1.91309004
80Ulnar bowing (HP:0003031)1.91001018
81Skin tags (HP:0010609)1.87904569
82Ankyloglossia (HP:0010296)1.87011575
83Cafe-au-lait spot (HP:0000957)1.85604976
84Patellar aplasia (HP:0006443)1.85568880
85Cutaneous melanoma (HP:0012056)1.85540034
86Fragile skin (HP:0001030)1.85427315
87Round ear (HP:0100830)1.85104135
88Enlarged penis (HP:0000040)1.84272282
89Easy fatigability (HP:0003388)1.83505262
90Amyotrophic lateral sclerosis (HP:0007354)1.83332678
91Biconcave vertebral bodies (HP:0004586)1.82583158
92Flat cornea (HP:0007720)1.82436617
93Ureteral stenosis (HP:0000071)1.81961753
94Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.81916627
95Short 1st metacarpal (HP:0010034)1.81916627
96Deep palmar crease (HP:0006191)1.81912814
97Radial bowing (HP:0002986)1.81690606
98Malignant gastrointestinal tract tumors (HP:0006749)1.81640677
99Gastrointestinal carcinoma (HP:0002672)1.81640677
100Aneurysm (HP:0002617)1.81622549
101Long eyelashes (HP:0000527)1.81015302
102Short phalanx of the thumb (HP:0009660)1.80936477
103Dislocated radial head (HP:0003083)1.80789990
104Pelvic girdle muscle weakness (HP:0003749)1.80629452
105Degeneration of anterior horn cells (HP:0002398)1.80590099
106Abnormality of the anterior horn cell (HP:0006802)1.80590099
107Colon cancer (HP:0003003)1.80365855
108Megalocornea (HP:0000485)1.80234423
109Esophageal varix (HP:0002040)1.79864939
110Recurrent viral infections (HP:0004429)1.79261420
111Abnormality of oral frenula (HP:0000190)1.78250347
112Thoracic kyphosis (HP:0002942)1.78164955
113Increased density of long bones (HP:0006392)1.77840087
114Premature skin wrinkling (HP:0100678)1.77602912
115Spina bifida occulta (HP:0003298)1.77203756
116Aplasia/Hypoplasia of the sternum (HP:0006714)1.77117780
117Broad palm (HP:0001169)1.77051270
118Increased variability in muscle fiber diameter (HP:0003557)1.75725723
119Mitral regurgitation (HP:0001653)1.75652025
120Vertebral compression fractures (HP:0002953)1.75109898
121Personality changes (HP:0000751)1.73492435
122Hypertensive crisis (HP:0100735)1.72920748
123Deep venous thrombosis (HP:0002625)1.72739653
124Increased IgE level (HP:0003212)1.72262930
125Short humerus (HP:0005792)1.72062627
126Bicuspid aortic valve (HP:0001647)1.71501287
127Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.71438509
128Angiofibromas (HP:0010615)1.71407898
129Adenoma sebaceum (HP:0009720)1.71407898
130Bowel incontinence (HP:0002607)1.70872949
131Fibroma (HP:0010614)1.70827840
132Rhabdomyosarcoma (HP:0002859)1.70752520
133Neoplasm of the pancreas (HP:0002894)1.69973937
134Patellar dislocation (HP:0002999)1.69325119
135Wrist flexion contracture (HP:0001239)1.69170677
136Neuronal loss in central nervous system (HP:0002529)1.68614243
137Aplasia/Hypoplasia of the patella (HP:0006498)1.68516988
138Fibrous tissue neoplasm (HP:0012316)1.67989689
139Metaphyseal cupping (HP:0003021)1.67241792
140Lower limb amyotrophy (HP:0007210)1.67161897
141Hypoparathyroidism (HP:0000829)1.66645907
142Inflammation of the large intestine (HP:0002037)1.66314296
143Abnormality of the distal phalanx of the thumb (HP:0009617)1.65701875
144Abnormality of the radial head (HP:0003995)1.65122668
145Abnormal large intestine physiology (HP:0012700)1.64916954
146Abnormality of calcium-phosphate metabolism (HP:0100530)1.63529961
147Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.63416855
148Cervical subluxation (HP:0003308)1.63105127
149Truncus arteriosus (HP:0001660)1.62942203
150Dysmetric saccades (HP:0000641)1.62854641
151Exercise-induced myalgia (HP:0003738)1.62812211
152Dilatation of the ascending aorta (HP:0005111)1.62558127
153Volvulus (HP:0002580)1.62153937
154Biliary tract neoplasm (HP:0100574)1.62141070
155Neoplasm of the heart (HP:0100544)1.61715723
156Distal lower limb muscle weakness (HP:0009053)1.61655622
157Trismus (HP:0000211)1.60975390
158Squamous cell carcinoma (HP:0002860)1.60204445
159Blue sclerae (HP:0000592)1.59571811
160Preauricular skin tag (HP:0000384)1.59009686
161Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.58707010
162Ureteral obstruction (HP:0006000)1.58649045
163Aplasia/hypoplasia of the humerus (HP:0006507)1.58598325
164Viral hepatitis (HP:0006562)1.58360354
165Emphysema (HP:0002097)1.57778839
166Atrophy/Degeneration involving motor neurons (HP:0007373)1.57688563
167Abnormality of skeletal muscle fiber size (HP:0012084)1.57449981
168Seborrheic dermatitis (HP:0001051)1.56577768
169Shoulder girdle muscle weakness (HP:0003547)1.56357721
170Hepatitis (HP:0012115)1.55520368
171Progressive muscle weakness (HP:0003323)1.54856682
172Gastrointestinal stroma tumor (HP:0100723)1.54167440
173Progressive external ophthalmoplegia (HP:0000590)1.54002281
174Interstitial pulmonary disease (HP:0006530)1.52779905
175Cutis marmorata (HP:0000965)1.52479066
176Truncal obesity (HP:0001956)1.52424587
177Persistence of primary teeth (HP:0006335)1.51924018
178Male infertility (HP:0003251)1.51910033
179Abnormality of the diencephalon (HP:0010662)1.51740481

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PASK3.97127470
2CDK123.71910105
3EEF2K3.58996507
4SMG13.48792985
5PRPF4B3.48209631
6TRIB33.26400216
7MAP3K102.97950026
8PKN22.96320860
9CDC72.88501855
10NEK22.72714598
11TAOK22.66314527
12NTRK22.36404373
13IRAK32.12849493
14ICK2.04227551
15TTK2.00686744
16NEK11.97135322
17RIPK41.95343122
18TTN1.94990318
19PRKD31.88733856
20STK101.61048832
21BUB11.60211205
22ALK1.58363883
23NME21.55164718
24BRD41.52226842
25PAK41.46660480
26PDGFRA1.45545803
27CAMKK11.42000386
28MTOR1.37958958
29TSSK61.33236959
30SCYL21.31635937
31RPS6KB21.31263125
32CDK41.30168828
33MAP3K131.28192529
34RIPK11.25525078
35TYRO31.24764114
36PDK41.24674916
37PDK31.24674916
38EPHA21.24617305
39LATS21.24112447
40MAP3K81.23577280
41PTK61.22179081
42MAP3K91.20203990
43CHEK11.20071836
44WEE11.18956671
45PLK11.17328243
46MAP4K11.15373406
47KSR21.14375595
48TAOK11.10513927
49SIK31.07742682
50ATR1.07700063
51TESK21.06820916
52BLK1.01483622
53MAP3K140.99188604
54RPS6KA40.94334427
55EPHB10.92819395
56MAPK110.89341422
57CDK70.88621431
58TESK10.88170264
59SIK20.86998255
60PAK60.85398059
61MAP2K60.84853200
62MAP3K110.84001015
63AURKB0.83958931
64FLT30.83363744
65CDK20.83352359
66LRRK20.82633124
67MAP3K10.82008144
68PAK20.81400995
69ERN10.81062273
70HIPK20.79920025
71CHEK20.79060078
72IRAK40.78078899
73PDPK10.76967791
74MAP3K30.76305176
75KSR10.75539893
76PLK30.74766096
77MAP3K60.73214353
78TYK20.71836962
79GRK60.70831418
80MST1R0.70700260
81PRKD20.69745296
82IRAK20.69013346
83FGFR10.66121304
84ATM0.66111707
85RPS6KA20.65749407
86BMX0.64989595
87LATS10.64426484
88CAMK1D0.64087927
89ZAP700.60546222
90CDK60.60094682
91TBK10.60011524
92MAP3K70.58135077
93SIK10.57635093
94ARAF0.57458596
95CDK10.56251685
96RPS6KL10.55920621
97RPS6KC10.55920621
98STK380.55638445
99MAPK120.53512371
100TGFBR10.53398691
101MAP2K20.52992403
102JAK30.51960553
103PNCK0.51723587
104CAMK1G0.51115495
105MOS0.50581383
106PDK10.50066837
107CDK90.49104361
108BTK0.48721091
109PTK20.48633566
110MAPKAPK30.48367177
111MELK0.48274827
112PAK10.47929056
113CDC42BPA0.46815238
114PRKDC0.46278252
115CSNK1D0.44781499
116PDGFRB0.44714420
117AURKA0.43881318
118BRSK10.43673447
119MARK30.42497225
120CLK10.41628575
121RET0.41401261
122CSNK1E0.41262805
123FES0.40897453
124AKT20.40764936
125MAP2K30.40091402
126DDR20.39956745
127PRKCH0.39885705
128STK40.39845879
129PRKCI0.39558120
130BRAF0.39206556
131HCK0.38505430
132MARK20.38155605
133FGFR30.37568922
134MAP3K50.37433248
135FGFR20.36734334
136GSK3B0.36594368
137RAF10.36188687
138MAPK140.35444417
139MAPK10.34547677
140RPS6KA10.33184061
141CDK80.32927751
142FGFR40.32674300
143STK30.32616129
144RPS6KA60.32526889
145CSK0.30860000
146DYRK1B0.28430355
147LMTK20.27116546
148TNK20.27071580

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA transport_Homo sapiens_hsa030132.57205860
2DNA replication_Homo sapiens_hsa030302.38290864
3mRNA surveillance pathway_Homo sapiens_hsa030152.34473403
4Spliceosome_Homo sapiens_hsa030402.23927375
5Mismatch repair_Homo sapiens_hsa034302.22655577
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.13321398
7Cell cycle_Homo sapiens_hsa041102.09660539
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.08253136
9Other glycan degradation_Homo sapiens_hsa005112.07441645
10Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.00008587
11Base excision repair_Homo sapiens_hsa034101.92471459
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.89624468
13One carbon pool by folate_Homo sapiens_hsa006701.78436798
14mTOR signaling pathway_Homo sapiens_hsa041501.65011746
15Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.56289029
16Sulfur relay system_Homo sapiens_hsa041221.55919533
17Oocyte meiosis_Homo sapiens_hsa041141.54451682
18Notch signaling pathway_Homo sapiens_hsa043301.49250822
19MicroRNAs in cancer_Homo sapiens_hsa052061.46014414
20Chronic myeloid leukemia_Homo sapiens_hsa052201.45429275
21Central carbon metabolism in cancer_Homo sapiens_hsa052301.41117708
22Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.38202518
23HTLV-I infection_Homo sapiens_hsa051661.28109660
24Thyroid hormone signaling pathway_Homo sapiens_hsa049191.26978372
25p53 signaling pathway_Homo sapiens_hsa041151.26815550
26Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.26442097
27Colorectal cancer_Homo sapiens_hsa052101.25381369
28Nucleotide excision repair_Homo sapiens_hsa034201.24905118
29Lysine degradation_Homo sapiens_hsa003101.23150842
30Osteoclast differentiation_Homo sapiens_hsa043801.22227857
31Endometrial cancer_Homo sapiens_hsa052131.22102050
32Small cell lung cancer_Homo sapiens_hsa052221.18642729
33Prion diseases_Homo sapiens_hsa050201.17899018
34Fructose and mannose metabolism_Homo sapiens_hsa000511.16374625
35Pentose phosphate pathway_Homo sapiens_hsa000301.16019181
36Hippo signaling pathway_Homo sapiens_hsa043901.14429161
37Non-small cell lung cancer_Homo sapiens_hsa052231.14166207
38Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.13806915
39Viral carcinogenesis_Homo sapiens_hsa052031.13276513
40Cyanoamino acid metabolism_Homo sapiens_hsa004601.12287434
41Vibrio cholerae infection_Homo sapiens_hsa051101.09870560
42Basal cell carcinoma_Homo sapiens_hsa052171.09403530
43* RNA degradation_Homo sapiens_hsa030181.05989911
44Dorso-ventral axis formation_Homo sapiens_hsa043201.04341166
45Fanconi anemia pathway_Homo sapiens_hsa034601.04112198
46Adherens junction_Homo sapiens_hsa045201.03759593
47Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.01906260
48Non-homologous end-joining_Homo sapiens_hsa034501.00792805
49Glioma_Homo sapiens_hsa052141.00456746
50Bladder cancer_Homo sapiens_hsa052190.98906509
51Proteoglycans in cancer_Homo sapiens_hsa052050.98822726
52Homologous recombination_Homo sapiens_hsa034400.97837876
53Toll-like receptor signaling pathway_Homo sapiens_hsa046200.97632724
54VEGF signaling pathway_Homo sapiens_hsa043700.96774366
55Neurotrophin signaling pathway_Homo sapiens_hsa047220.96371287
56Acute myeloid leukemia_Homo sapiens_hsa052210.96233360
57Epstein-Barr virus infection_Homo sapiens_hsa051690.95916151
58Pancreatic cancer_Homo sapiens_hsa052120.94675331
59HIF-1 signaling pathway_Homo sapiens_hsa040660.92661265
60Focal adhesion_Homo sapiens_hsa045100.92227747
61Hedgehog signaling pathway_Homo sapiens_hsa043400.91148738
62Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.88829804
63Influenza A_Homo sapiens_hsa051640.88155603
64Estrogen signaling pathway_Homo sapiens_hsa049150.86980663
65Biosynthesis of amino acids_Homo sapiens_hsa012300.86635227
66Leishmaniasis_Homo sapiens_hsa051400.86399031
67Viral myocarditis_Homo sapiens_hsa054160.85746940
68Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.85087111
69Longevity regulating pathway - mammal_Homo sapiens_hsa042110.84879578
70NF-kappa B signaling pathway_Homo sapiens_hsa040640.82936754
71TNF signaling pathway_Homo sapiens_hsa046680.82569588
72Choline metabolism in cancer_Homo sapiens_hsa052310.82176146
73B cell receptor signaling pathway_Homo sapiens_hsa046620.81865269
74Thyroid cancer_Homo sapiens_hsa052160.80952416
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.80067617
76Hepatitis C_Homo sapiens_hsa051600.78730520
77Renal cell carcinoma_Homo sapiens_hsa052110.78331978
78Antigen processing and presentation_Homo sapiens_hsa046120.78313233
79Glycosaminoglycan degradation_Homo sapiens_hsa005310.78046308
80Platelet activation_Homo sapiens_hsa046110.76080237
81T cell receptor signaling pathway_Homo sapiens_hsa046600.74366169
82Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.73908967
83Glucagon signaling pathway_Homo sapiens_hsa049220.73389641
84Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.72813230
85Shigellosis_Homo sapiens_hsa051310.72558641
86Pathways in cancer_Homo sapiens_hsa052000.69948338
87Basal transcription factors_Homo sapiens_hsa030220.69848612
88Herpes simplex infection_Homo sapiens_hsa051680.69571718
89AMPK signaling pathway_Homo sapiens_hsa041520.69458350
90Insulin signaling pathway_Homo sapiens_hsa049100.69399270
91Melanogenesis_Homo sapiens_hsa049160.68675323
92Type II diabetes mellitus_Homo sapiens_hsa049300.68440322
93AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.68068747
94Chemokine signaling pathway_Homo sapiens_hsa040620.67896615
95Measles_Homo sapiens_hsa051620.67529043
96Aldosterone synthesis and secretion_Homo sapiens_hsa049250.67516086
97Apoptosis_Homo sapiens_hsa042100.67362398
98Insulin resistance_Homo sapiens_hsa049310.67207920
992-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.67029684
100Tight junction_Homo sapiens_hsa045300.66773270
101Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.66435841
102Prostate cancer_Homo sapiens_hsa052150.66362822
103Galactose metabolism_Homo sapiens_hsa000520.66203610
104Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.64626323
105Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.64616907
106Hepatitis B_Homo sapiens_hsa051610.64566976
107Tuberculosis_Homo sapiens_hsa051520.64463170
108Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.63844593
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63406507
110RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.63321900
111TGF-beta signaling pathway_Homo sapiens_hsa043500.62971840
112Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62568576
113Long-term potentiation_Homo sapiens_hsa047200.62449323
114Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61873506
115FoxO signaling pathway_Homo sapiens_hsa040680.61781768
116Dilated cardiomyopathy_Homo sapiens_hsa054140.59534738
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.59314556
118Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58434354
119Wnt signaling pathway_Homo sapiens_hsa043100.57710308
120Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57555209
121Thyroid hormone synthesis_Homo sapiens_hsa049180.56695564
122Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.56541919
123Gap junction_Homo sapiens_hsa045400.55629297
124Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55316245
125Alcoholism_Homo sapiens_hsa050340.55272658
126ErbB signaling pathway_Homo sapiens_hsa040120.55268357
127MAPK signaling pathway_Homo sapiens_hsa040100.54669418
128Phospholipase D signaling pathway_Homo sapiens_hsa040720.54428985
129Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54342817
130Amoebiasis_Homo sapiens_hsa051460.53921416
131Primary immunodeficiency_Homo sapiens_hsa053400.53394804
132Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53241598
133GnRH signaling pathway_Homo sapiens_hsa049120.52577989
134cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52116446
135Prolactin signaling pathway_Homo sapiens_hsa049170.52051630
136Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50401219
137Toxoplasmosis_Homo sapiens_hsa051450.49991012
138Inositol phosphate metabolism_Homo sapiens_hsa005620.49840069
139Leukocyte transendothelial migration_Homo sapiens_hsa046700.49678076
140Oxytocin signaling pathway_Homo sapiens_hsa049210.49114191

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