ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	thyroid hormone generation (GO:0006590)	9.46648151
2	regulation of clathrin-mediated endocytosis (GO:2000369)	8.09166773
3	thyroid hormone metabolic process (GO:0042403)	7.89190014
4	fusion of sperm to egg plasma membrane (GO:0007342)	7.40469861
5	regulation of acrosome reaction (GO:0060046)	7.36682802
6	positive regulation of antigen processing and presentation (GO:0002579)	7.24168875
7	seminiferous tubule development (GO:0072520)	6.50255826
8	regulation of antigen processing and presentation (GO:0002577)	5.75967782
9	plasma membrane fusion (GO:0045026)	5.62473674
10	negative regulation of receptor-mediated endocytosis (GO:0048261)	4.98874015
11	complement activation, alternative pathway (GO:0006957)	4.81870583
12	response to parathyroid hormone (GO:0071107)	4.70752773
13	sulfur amino acid catabolic process (GO:0000098)	4.68596320
14	kynurenine metabolic process (GO:0070189)	4.51466223
15	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	4.22420574
16	macroautophagy (GO:0016236)	4.14351348
17	regulation of T cell tolerance induction (GO:0002664)	4.11714513
18	regulation of Cdc42 GTPase activity (GO:0043088)	3.84466536
19	production of molecular mediator involved in inflammatory response (GO:0002532)	3.76594251
20	valine metabolic process (GO:0006573)	3.66186651
21	cellular sodium ion homeostasis (GO:0006883)	3.65449202
22	thyroid gland development (GO:0030878)	3.55931091
23	cysteine metabolic process (GO:0006534)	3.51039095
24	positive regulation of tolerance induction (GO:0002645)	3.46011870
25	tryptophan catabolic process (GO:0006569)	3.34373170
26	indole-containing compound catabolic process (GO:0042436)	3.34373170
27	indolalkylamine catabolic process (GO:0046218)	3.34373170
28	negative regulation of endopeptidase activity (GO:0010951)	3.31947408
29	alpha-linolenic acid metabolic process (GO:0036109)	3.28182160
30	response to misfolded protein (GO:0051788)	3.26239444
31	regulation of epithelial cell differentiation involved in kidney development (GO:2000696)	3.21147903
32	negative regulation of peptidase activity (GO:0010466)	3.17877590
33	negative regulation of metanephros development (GO:0072217)	3.13303431
34	regulation of nephron tubule epithelial cell differentiation (GO:0072182)	3.12604722
35	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.10559811
36	ethanol oxidation (GO:0006069)	3.08140749
37	eye photoreceptor cell differentiation (GO:0001754)	2.99019791
38	photoreceptor cell differentiation (GO:0046530)	2.99019791
39	tryptophan metabolic process (GO:0006568)	2.92087777
40	regulation of tolerance induction (GO:0002643)	2.91191063
41	sodium ion homeostasis (GO:0055078)	2.91034172
42	metanephric tubule development (GO:0072170)	2.88824464
43	metanephric nephron tubule development (GO:0072234)	2.88824464
44	drug transmembrane transport (GO:0006855)	2.87260470
45	benzene-containing compound metabolic process (GO:0042537)	2.86802779
46	organic cation transport (GO:0015695)	2.85642877
47	regulation of calcium ion-dependent exocytosis (GO:0017158)	2.79755593
48	regulation of hydrogen peroxide metabolic process (GO:0010310)	2.77187623
49	hydrogen peroxide catabolic process (GO:0042744)	2.76692942
50	negative regulation of protein autophosphorylation (GO:0031953)	2.74616889
51	sperm capacitation (GO:0048240)	2.74573968
52	cytolysis (GO:0019835)	2.72428901
53	aromatic amino acid family catabolic process (GO:0009074)	2.72154977
54	response to lead ion (GO:0010288)	2.69665706
55	cellular modified amino acid catabolic process (GO:0042219)	2.65936556
56	metanephric nephron epithelium development (GO:0072243)	2.65390728
57	response to nitrosative stress (GO:0051409)	2.63648391
58	regulation of complement activation (GO:0030449)	2.60667538
59	hypotonic response (GO:0006971)	2.60172558
60	quaternary ammonium group transport (GO:0015697)	2.58681563
61	nephron tubule formation (GO:0072079)	2.57053878
62	amino-acid betaine transport (GO:0015838)	2.56211397
63	carnitine transport (GO:0015879)	2.56211397
64	regulation of hydrogen peroxide-induced cell death (GO:1903205)	2.53746911
65	phosphate ion homeostasis (GO:0055062)	2.49266161
66	trivalent inorganic anion homeostasis (GO:0072506)	2.49266161
67	phospholipid homeostasis (GO:0055091)	2.48078004
68	tricarboxylic acid metabolic process (GO:0072350)	2.47441222
69	regulation of protein activation cascade (GO:2000257)	2.46849730
70	peptide catabolic process (GO:0043171)	2.46690967
71	regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)	2.44781176
72	negative regulation of endocytosis (GO:0045806)	2.44164597
73	nephron tubule development (GO:0072080)	2.43957956
74	drug transport (GO:0015893)	2.42752012
75	GPI anchor biosynthetic process (GO:0006506)	2.42564400
76	low-density lipoprotein particle clearance (GO:0034383)	2.42412967
77	phosphorelay signal transduction system (GO:0000160)	2.41953930
78	Golgi transport vesicle coating (GO:0048200)	2.40385220
79	COPI coating of Golgi vesicle (GO:0048205)	2.40385220
80	positive regulation of glycogen biosynthetic process (GO:0045725)	2.37642591
81	triglyceride catabolic process (GO:0019433)	2.35636758
82	fatty acid beta-oxidation (GO:0006635)	2.35375513
83	metanephric epithelium development (GO:0072207)	2.34297557
84	sulfate transmembrane transport (GO:1902358)	2.33983432
85	collecting duct development (GO:0072044)	2.33956243
86	branched-chain amino acid metabolic process (GO:0009081)	2.33704222
87	regulation of chronic inflammatory response (GO:0002676)	2.32793593
88	brown fat cell differentiation (GO:0050873)	2.30359637
89	mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)	2.28475702
90	epithelial cell differentiation involved in kidney development (GO:0035850)	2.27887064
91	GPI anchor metabolic process (GO:0006505)	2.27279107
92	mannose metabolic process (GO:0006013)	2.27191109
93	oxaloacetate metabolic process (GO:0006107)	2.26260358
94	regulation of lipoprotein metabolic process (GO:0050746)	2.23753055
95	negative regulation of proteolysis (GO:0045861)	2.19935757
96	antigen processing and presentation of endogenous peptide antigen (GO:0002483)	16.6982565
97	antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)	16.6982565
98	antigen processing and presentation via MHC class Ib (GO:0002475)	15.9315708
99	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	14.7690273
100	antigen processing and presentation of endogenous antigen (GO:0019883)	13.8637087

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	4.37330063
2	ESR1_21235772_ChIP-Seq_MCF-7_Human	3.15219275
3	AR_21572438_ChIP-Seq_LNCaP_Human	2.76306999
4	ESR2_21235772_ChIP-Seq_MCF-7_Human	2.72061357
5	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.66024994
6	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	2.55522489
7	TRIM28_21343339_ChIP-Seq_HEK293_Human	2.43768313
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.28745409
9	CLOCK_20551151_ChIP-Seq_293T_Human	2.28231716
10	RXR_22158963_ChIP-Seq_LIVER_Mouse	2.24572761
11	LXR_22158963_ChIP-Seq_LIVER_Mouse	2.20191990
12	ZNF263_19887448_ChIP-Seq_K562_Human	2.18513427
13	GATA1_22025678_ChIP-Seq_K562_Human	10.0322469
14	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.87815663
15	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.59196933
16	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.56978344
17	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.45793859
18	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	1.38482383
19	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	1.36297756
20	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.34797335
21	STAT1_17558387_ChIP-Seq_HELA_Human	1.31844972
22	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.31703461
23	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.31294681
24	SOX2_20726797_ChIP-Seq_SW620_Human	1.28712797
25	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.24564434
26	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.24490644
27	LXR_22292898_ChIP-Seq_THP-1_Human	1.24278445
28	MYC_19915707_ChIP-ChIP_AK7_Human	1.23256573
29	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.23146181
30	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.22201816
31	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.21912780
32	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.20484289
33	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.18998864
34	CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.18757344
35	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	1.18657817
36	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.18488670
37	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.17429551
38	VDR_24787735_ChIP-Seq_THP-1_Human	1.13087901
39	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.13068456
40	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.12068429
41	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.10333129
42	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.08587428
43	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.08187993
44	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.04267510
45	P68_20966046_ChIP-Seq_HELA_Human	1.02716458
46	TBX20_22328084_ChIP-Seq_HEART_Mouse	1.01066863
47	TBX20_22080862_ChIP-Seq_HEART_Mouse	1.01066863
48	CSB_26484114_Chip-Seq_FIBROBLAST_Human	1.01005424
49	RACK7_27058665_Chip-Seq_MCF-7_Human	1.00715013
50	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.00180511
51	AHR_22903824_ChIP-Seq_MCF-7_Human	1.00179271
52	ELK4_26923725_Chip-Seq_MESODERM_Mouse	0.98438725
53	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.97040460
54	OCT4_20526341_ChIP-Seq_ESCs_Human	0.95620676
55	CEBPB_22108803_ChIP-Seq_LS180_Human	0.94910909
56	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.94411293
57	RNF2_18974828_ChIP-Seq_MESCs_Mouse	0.94411293
58	RARG_19884340_ChIP-ChIP_MEFs_Mouse	0.94077769
59	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.93680733
60	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.93662942
61	SOX9_24532713_ChIP-Seq_HFSC_Mouse	0.92796960
62	ZNF274_21170338_ChIP-Seq_K562_Hela	0.92752269
63	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.91368976
64	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	0.91341505
65	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.90299838
66	TP63_23658742_ChIP-Seq_EP156T_Human	0.89510790
67	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	0.89488505
68	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.89367189
69	TP63_17297297_ChIP-ChIP_HaCaT_Human	0.87639755
70	KDM2B_26808549_Chip-Seq_K562_Human	0.87236148
71	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	0.87038792
72	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.86705298
73	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.86219429
74	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.85128543
75	FOXA2_19822575_ChIP-Seq_HepG2_Human	0.84464248
76	FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.83962172
77	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	0.83585259
78	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	0.83544381
79	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.83024165
80	SMRT_27268052_Chip-Seq_Bcells_Human	0.82473144
81	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.82137837
82	WT1_25993318_ChIP-Seq_PODOCYTE_Human	0.82043555
83	RUNX1_27514584_Chip-Seq_MCF-7_Human	0.81676067
84	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.81470385
85	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.80515402
86	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.79654654
87	SALL4_18804426_ChIP-ChIP_XEN_Mouse	0.79421208
88	NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human	0.78986296
89	BCOR_27268052_Chip-Seq_Bcells_Human	0.78590258
90	SMC4_20622854_ChIP-Seq_HELA_Human	0.78486421
91	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.78186467
92	TAF2_19829295_ChIP-Seq_ESCs_Human	0.77984239
93	FLI1_21867929_ChIP-Seq_CD8_Mouse	0.75942725
94	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	0.75114005
95	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	0.74948307
96	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.74246952
97	SMAD4_21741376_ChIP-Seq_ESCs_Human	0.74137194
98	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.73966332
99	GATA3_24758297_ChIP-Seq_MCF-7_Human	0.73877963
100	CJUN_26792858_Chip-Seq_BT549_Human	0.72754603

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005058_abnormal_lysosome_morphology	5.11769797
2	MP0004043_abnormal_pH_regulation	4.64112039
3	MP0002139_abnormal_hepatobiliary_system	3.93783339
4	MP0000681_abnormal_thyroid_gland	3.71763260
5	MP0003195_calcinosis	3.19578228
6	MP0010234_abnormal_vibrissa_follicle	2.95498500
7	MP0010678_abnormal_skin_adnexa	2.55886934
8	MP0005360_urolithiasis	2.48682617
9	MP0002876_abnormal_thyroid_physiology	2.45680702
10	MP0002138_abnormal_hepatobiliary_system	2.42801134
11	MP0000383_abnormal_hair_follicle	2.42487480
12	MP0005377_hearing/vestibular/ear_phenot	2.29828590
13	MP0003878_abnormal_ear_physiology	2.29828590
14	MP0003300_gastrointestinal_ulcer	2.25801665
15	MP0009643_abnormal_urine_homeostasis	2.24864862
16	MP0005670_abnormal_white_adipose	2.17348976
17	MP0001765_abnormal_ion_homeostasis	2.16101362
18	MP0001756_abnormal_urination	2.05052025
19	MP0000678_abnormal_parathyroid_gland	2.03940403
20	MP0004019_abnormal_vitamin_homeostasis	2.02815387
21	MP0005666_abnormal_adipose_tissue	2.02002085
22	MP0005332_abnormal_amino_acid	1.86395181
23	MP0005375_adipose_tissue_phenotype	1.85999094
24	MP0005636_abnormal_mineral_homeostasis	1.85794241
25	MP0003705_abnormal_hypodermis_morpholog	1.85189667
26	MP0008438_abnormal_cutaneous_collagen	1.84347374
27	MP0004185_abnormal_adipocyte_glucose	1.83953028
28	MP0002254_reproductive_system_inflammat	1.78844856
29	MP0000003_abnormal_adipose_tissue	1.69571756
30	MP0010329_abnormal_lipoprotein_level	1.63714084
31	MP0005365_abnormal_bile_salt	1.61050122
32	MP0003191_abnormal_cellular_cholesterol	1.55491439
33	MP0005275_abnormal_skin_tensile	1.55310147
34	MP0004130_abnormal_muscle_cell	1.52344831
35	MP0005584_abnormal_enzyme/coenzyme_acti	1.49063102
36	MP0002168_other_aberrant_phenotype	1.48567934
37	MP0003303_peritoneal_inflammation	1.46978843
38	MP0002136_abnormal_kidney_physiology	1.46749392
39	MP0010386_abnormal_urinary_bladder	1.39796978
40	MP0008995_early_reproductive_senescence	1.38250131
41	MP0003566_abnormal_cell_adhesion	1.33332107
42	MP0008875_abnormal_xenobiotic_pharmacok	1.31838226
43	MP0003252_abnormal_bile_duct	1.31128626
44	MP0002118_abnormal_lipid_homeostasis	1.28474626
45	MP0001958_emphysema	1.27285480
46	MP0004264_abnormal_extraembryonic_tissu	1.20446782
47	MP0009780_abnormal_chondrocyte_physiolo	1.20300483
48	MP0002837_dystrophic_cardiac_calcinosis	1.17407520
49	MP0002796_impaired_skin_barrier	1.17328744
50	MP0004885_abnormal_endolymph	1.15480102
51	MP0004858_abnormal_nervous_system	1.14866156
52	MP0002896_abnormal_bone_mineralization	1.14814963
53	MP0002653_abnormal_ependyma_morphology	1.13842126
54	MP0003879_abnormal_hair_cell	1.12649029
55	MP0004036_abnormal_muscle_relaxation	1.11315946
56	MP0004272_abnormal_basement_membrane	1.11276473
57	MP0005085_abnormal_gallbladder_physiolo	1.09139407
58	MP0005410_abnormal_fertilization	1.07678482
59	MP0000462_abnormal_digestive_system	1.02793643
60	MP0003075_altered_response_to	1.01501228
61	MP0009384_cardiac_valve_regurgitation	0.94831740
62	MP0005319_abnormal_enzyme/_coenzyme	0.93174163
63	MP0000538_abnormal_urinary_bladder	0.92984549
64	MP0000609_abnormal_liver_physiology	0.91170174
65	MP0002295_abnormal_pulmonary_circulatio	0.91071568
66	MP0000534_abnormal_ureter_morphology	0.89829752
67	MP0003172_abnormal_lysosome_physiology	0.89075821
68	MP0003045_fibrosis	0.87749618
69	MP0009763_increased_sensitivity_to	0.87566940
70	MP0001501_abnormal_sleep_pattern	0.86640009
71	MP0003690_abnormal_glial_cell	0.85039771
72	MP0002234_abnormal_pharynx_morphology	0.83963273
73	MP0001666_abnormal_nutrient_absorption	0.83887903
74	MP0008004_abnormal_stomach_pH	0.83494735
75	MP0004084_abnormal_cardiac_muscle	0.81011653
76	MP0003329_amyloid_beta_deposits	0.80631834
77	MP0000537_abnormal_urethra_morphology	0.79358315
78	MP0002971_abnormal_brown_adipose	0.77942011
79	MP0005395_other_phenotype	0.77137104
80	MP0000230_abnormal_systemic_arterial	0.74271220
81	MP0009115_abnormal_fat_cell	0.74259237
82	MP0003638_abnormal_response/metabolism_	0.72198952
83	MP0005408_hypopigmentation	0.72143291
84	MP0003656_abnormal_erythrocyte_physiolo	0.71900998
85	MP0002135_abnormal_kidney_morphology	0.71363670
86	MP0003186_abnormal_redox_activity	0.68709562
87	MP0008961_abnormal_basal_metabolism	0.68227762
88	MP0000604_amyloidosis	0.67228569
89	MP0005381_digestive/alimentary_phenotyp	0.66717003
90	MP0003806_abnormal_nucleotide_metabolis	0.64923327
91	MP0001177_atelectasis	0.63665099
92	MP0003953_abnormal_hormone_level	0.62034159
93	MP0005535_abnormal_body_temperature	0.61067029
94	MP0003183_abnormal_peptide_metabolism	0.61010161
95	MP0006138_congestive_heart_failure	0.59291110
96	MP0005310_abnormal_salivary_gland	0.59009550
97	MP0005334_abnormal_fat_pad	0.58860972
98	MP0010771_integument_phenotype	0.52911048
99	MP0005620_abnormal_muscle_contractility	0.52536831
100	MP0003795_abnormal_bone_structure	0.51321763

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Goiter (HP:0000853)	5.69111073
2	Complement deficiency (HP:0004431)	5.66380418
3	Hyperphosphatemia (HP:0002905)	5.26958442
4	Choroideremia (HP:0001139)	5.26075407
5	Pili torti (HP:0003777)	5.13917906
6	Vacuolated lymphocytes (HP:0001922)	4.86528737
7	Abnormality of the fovea (HP:0000493)	4.83456660
8	Thyroid-stimulating hormone excess (HP:0002925)	4.53170234
9	Potter facies (HP:0002009)	4.43594048
10	Facial shape deformation (HP:0011334)	4.43594048
11	Vascular calcification (HP:0004934)	4.13020303
12	Abnormal rod and cone electroretinograms (HP:0008323)	3.97962161
13	Abnormality of complement system (HP:0005339)	3.91288801
14	Recurrent gram-negative bacterial infections (HP:0005420)	3.85201949
15	Cardiovascular calcification (HP:0011915)	3.83972180
16	Proximal tubulopathy (HP:0000114)	3.76673013
17	Metaphyseal cupping (HP:0003021)	3.74545611
18	Hand muscle atrophy (HP:0009130)	3.69444565
19	Bony spicule pigmentary retinopathy (HP:0007737)	3.53671572
20	Hyperglycinuria (HP:0003108)	3.45878703
21	Abnormal hair laboratory examination (HP:0003328)	3.28684847
22	Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)	3.23859557
23	Tubulointerstitial fibrosis (HP:0005576)	3.19067901
24	Stridor (HP:0010307)	3.16885609
25	Upper limb amyotrophy (HP:0009129)	3.14845385
26	Distal upper limb amyotrophy (HP:0007149)	3.14845385
27	Hypopigmentation of the fundus (HP:0007894)	3.04490059
28	Hypophosphatemic rickets (HP:0004912)	3.03594831
29	Facial diplegia (HP:0001349)	3.01382741
30	Tetany (HP:0001281)	2.98984393
31	Abnormality of chloride homeostasis (HP:0011422)	2.95902766
32	Myocardial infarction (HP:0001658)	2.93176058
33	Abnormality of macular pigmentation (HP:0008002)	2.91708380
34	Action tremor (HP:0002345)	2.87287150
35	11 pairs of ribs (HP:0000878)	2.86002022
36	Diaphragmatic weakness (HP:0009113)	2.85124659
37	Hyperactive renin-angiotensin system (HP:0000841)	2.83983014
38	Ketoacidosis (HP:0001993)	2.83382532
39	Cervical subluxation (HP:0003308)	2.79700153
40	Dysostosis multiplex (HP:0000943)	2.77058678
41	Mucopolysacchariduria (HP:0008155)	2.73829695
42	Urinary glycosaminoglycan excretion (HP:0003541)	2.73829695
43	Abnormality of glycine metabolism (HP:0010895)	2.73826440
44	Abnormality of serine family amino acid metabolism (HP:0010894)	2.73826440
45	Intention tremor (HP:0002080)	2.67845324
46	Abnormality of polysaccharide metabolism (HP:0011012)	2.60970028
47	Abnormality of glycosaminoglycan metabolism (HP:0004371)	2.60970028
48	Abnormality of mucopolysaccharide metabolism (HP:0011020)	2.60970028
49	Muscle fiber splitting (HP:0003555)	2.54953462
50	Central scotoma (HP:0000603)	2.52432064
51	Neurofibrillary tangles (HP:0002185)	2.50672618
52	Nonprogressive disorder (HP:0003680)	2.45212028
53	Focal segmental glomerulosclerosis (HP:0000097)	2.43728952
54	Hypokalemic alkalosis (HP:0001949)	2.39395828
55	Abnormality of purine metabolism (HP:0004352)	2.36145819
56	Hyperglycinemia (HP:0002154)	2.35448134
57	Malnutrition (HP:0004395)	2.34718165
58	Gout (HP:0001997)	2.32518852
59	Cerebral inclusion bodies (HP:0100314)	2.31716429
60	Rickets (HP:0002748)	2.29245852
61	Thin bony cortex (HP:0002753)	2.22904181
62	Aortic aneurysm (HP:0004942)	2.22745753
63	Ulnar deviation of the wrist (HP:0003049)	2.19858164
64	Ketosis (HP:0001946)	2.18454451
65	Onycholysis (HP:0001806)	2.16533915
66	Cone-rod dystrophy (HP:0000548)	2.13585413
67	Abnormality of the calcaneus (HP:0008364)	2.13181295
68	Infantile muscular hypotonia (HP:0008947)	2.10593454
69	Glomerulosclerosis (HP:0000096)	2.08668843
70	Bicornuate uterus (HP:0000813)	2.08603326
71	Abnormal hemoglobin (HP:0011902)	2.07792308
72	Delayed CNS myelination (HP:0002188)	2.03046685
73	Missing ribs (HP:0000921)	2.02148772
74	Polar cataract (HP:0010696)	1.99569298
75	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.97084448
76	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.97084448
77	Hyperaldosteronism (HP:0000859)	1.94903265
78	Agitation (HP:0000713)	1.94713836
79	Subcapsular cataract (HP:0000523)	1.94011038
80	Acanthosis nigricans (HP:0000956)	1.89347144
81	Aortic dissection (HP:0002647)	1.88904885
82	Hypophosphatemia (HP:0002148)	1.88833227
83	Progressive visual loss (HP:0000529)	1.87598985
84	Osteomalacia (HP:0002749)	1.85741117
85	Aplasia of the musculature (HP:0100854)	1.84216244
86	Metabolic alkalosis (HP:0200114)	1.81047187
87	Abnormality of renal excretion (HP:0011036)	1.79198900
88	Oligomenorrhea (HP:0000876)	1.78707108
89	Abnormality of the vocal cords (HP:0008777)	1.78185662
90	Hyperpituitarism (HP:0010514)	1.73235617
91	Back pain (HP:0003418)	1.71511585
92	Tubulointerstitial abnormality (HP:0001969)	1.71294380
93	Hemiplegia (HP:0002301)	1.71059812
94	Abnormality of nucleobase metabolism (HP:0010932)	1.70463270
95	Disproportionate short-trunk short stature (HP:0003521)	1.69733038
96	Coarse facial features (HP:0000280)	1.65073848
97	Myopathic facies (HP:0002058)	1.65073307
98	Macular degeneration (HP:0000608)	1.64965307
99	Ectopia lentis (HP:0001083)	1.63372861
100	Hypothyroidism (HP:0000821)	1.62693553

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	3.85185309
2	WNK4	3.51198065
3	TRIB3	3.41864834
4	MYLK	3.33761319
5	LATS1	3.00906908
6	SIK1	2.59319939
7	MST4	2.55412180
8	LMTK2	2.48233511
9	AKT3	2.45486043
10	ERN1	2.33460353
11	FRK	2.29197138
12	STK38L	2.17071954
13	EPHB1	1.75081987
14	RIPK1	1.71146945
15	PKN2	1.70471726
16	LRRK2	1.68489908
17	BCKDK	1.68484389
18	PRKD3	1.64721934
19	LATS2	1.63207987
20	FER	1.62576992
21	FGFR2	1.61337547
22	CAMK1D	1.60900509
23	MAP3K6	1.60071972
24	TTN	1.56000803
25	RET	1.47268495
26	INSRR	1.35848764
27	PDGFRA	1.33654670
28	PTK2	1.33073706
29	STK38	1.31826892
30	KSR2	1.28191681
31	DMPK	1.23907602
32	CAMK1G	1.23157989
33	IRAK3	1.21165031
34	PAK3	1.19465247
35	MAP3K2	1.18869407
36	DDR2	1.18494560
37	PAK2	1.11618783
38	MAP2K4	1.06485481
39	WNK1	1.01322820
40	ERBB4	0.98085048
41	PDK3	0.94483742
42	PDK4	0.94483742
43	EEF2K	0.92165331
44	FGFR4	0.91543309
45	STK39	0.90995746
46	BMX	0.90951185
47	NTRK1	0.89939492
48	IRAK2	0.89582758
49	PTK6	0.82698620
50	NEK1	0.82311731
51	TYRO3	0.80422278
52	JAK2	0.79596497
53	DAPK2	0.79593803
54	MAP3K4	0.75780779
55	STK10	0.75397871
56	EPHB2	0.72547282
57	TESK1	0.70392002
58	MAP2K1	0.68120268
59	PRKCI	0.68002167
60	GRK6	0.64086644
61	RIPK4	0.63817365
62	MATK	0.62505816
63	PTK2B	0.60950251
64	PRKCH	0.60227558
65	PAK4	0.60170358
66	PDK2	0.58970887
67	OXSR1	0.58249764
68	EGFR	0.57048748
69	MST1R	0.56750081
70	ERBB2	0.56251685
71	PHKG2	0.55104987
72	PHKG1	0.55104987
73	PRKCZ	0.54973513
74	PDPK1	0.52928588
75	ILK	0.50584150
76	PIK3CG	0.49346606
77	GSK3A	0.47963717
78	SGK1	0.47804019
79	IRAK1	0.46852467
80	MET	0.46522456
81	STK3	0.46517862
82	DAPK3	0.44912212
83	INSR	0.43922511
84	MAP3K9	0.43916507
85	MAPKAPK3	0.43889647
86	SRC	0.42235874
87	FYN	0.42067603
88	ROCK1	0.40962939
89	PAK6	0.40253864
90	TAOK1	0.40157160
91	PDK1	0.38559668
92	PRKAA2	0.37476941
93	TTK	0.36779377
94	PRKD1	0.35909628
95	DYRK1B	0.33744039
96	JAK1	0.33331115
97	MTOR	0.33274477
98	PRKAA1	0.32392580
99	PDGFRB	0.32116421
100	MAP2K2	0.32046937

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Thyroid hormone synthesis_Homo sapiens_hsa04918	3.25628647
2	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	3.11120562
3	Nitrogen metabolism_Homo sapiens_hsa00910	2.92832574
4	Sulfur metabolism_Homo sapiens_hsa00920	2.86278408
5	ABC transporters_Homo sapiens_hsa02010	2.55435887
6	Fatty acid degradation_Homo sapiens_hsa00071	2.51040037
7	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.46660835
8	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.26487495
9	Other glycan degradation_Homo sapiens_hsa00511	2.24644878
10	Fatty acid metabolism_Homo sapiens_hsa01212	2.24615813
11	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	2.17506466
12	PPAR signaling pathway_Homo sapiens_hsa03320	2.14903708
13	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.11137792
14	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.07529008
15	Tyrosine metabolism_Homo sapiens_hsa00350	2.01408634
16	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.87286694
17	Glutathione metabolism_Homo sapiens_hsa00480	1.85713566
18	Tryptophan metabolism_Homo sapiens_hsa00380	1.81284226
19	Glycerolipid metabolism_Homo sapiens_hsa00561	1.73053358
20	Propanoate metabolism_Homo sapiens_hsa00640	1.70949857
21	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.63800275
22	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.62056619
23	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	1.60445975
24	Arginine biosynthesis_Homo sapiens_hsa00220	1.58997160
25	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.58173709
26	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.49138696
27	Butanoate metabolism_Homo sapiens_hsa00650	1.43660393
28	Pyruvate metabolism_Homo sapiens_hsa00620	1.41542089
29	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.34289961
30	Lysosome_Homo sapiens_hsa04142	1.31915399
31	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.30616782
32	Bile secretion_Homo sapiens_hsa04976	1.23407877
33	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.18412370
34	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.17469634
35	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.16923461
36	beta-Alanine metabolism_Homo sapiens_hsa00410	1.15447818
37	Peroxisome_Homo sapiens_hsa04146	1.12033626
38	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.12010307
39	Salivary secretion_Homo sapiens_hsa04970	1.08803971
40	Gastric acid secretion_Homo sapiens_hsa04971	1.06529948
41	Mineral absorption_Homo sapiens_hsa04978	1.06265148
42	Carbon metabolism_Homo sapiens_hsa01200	1.05592694
43	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.05250812
44	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.04256856
45	Prion diseases_Homo sapiens_hsa05020	1.03878261
46	Protein digestion and absorption_Homo sapiens_hsa04974	1.03104551
47	Complement and coagulation cascades_Homo sapiens_hsa04610	1.02098094
48	Fat digestion and absorption_Homo sapiens_hsa04975	0.98861212
49	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.98718968
50	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.96758005
51	Phenylalanine metabolism_Homo sapiens_hsa00360	0.95865973
52	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.90120216
53	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.83079172
54	Chemical carcinogenesis_Homo sapiens_hsa05204	0.81871140
55	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.79696446
56	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.77760780
57	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.77620554
58	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.75593721
59	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.74119175
60	Collecting duct acid secretion_Homo sapiens_hsa04966	0.72509193
61	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.70463432
62	ECM-receptor interaction_Homo sapiens_hsa04512	0.65808886
63	Arginine and proline metabolism_Homo sapiens_hsa00330	0.61918371
64	Renin secretion_Homo sapiens_hsa04924	0.59241841
65	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.56057560
66	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.55922340
67	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.54957898
68	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.52196432
69	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.45318467
70	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.44359534
71	African trypanosomiasis_Homo sapiens_hsa05143	0.42910206
72	Focal adhesion_Homo sapiens_hsa04510	0.40285243
73	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.39915396
74	Insulin resistance_Homo sapiens_hsa04931	0.39345986
75	Linoleic acid metabolism_Homo sapiens_hsa00591	0.38397536
76	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.37840659
77	Selenocompound metabolism_Homo sapiens_hsa00450	0.36966494
78	Vibrio cholerae infection_Homo sapiens_hsa05110	0.35974020
79	Estrogen signaling pathway_Homo sapiens_hsa04915	0.35853345
80	AMPK signaling pathway_Homo sapiens_hsa04152	0.35740364
81	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.33901081
82	Lysine degradation_Homo sapiens_hsa00310	0.33827970
83	Sphingolipid metabolism_Homo sapiens_hsa00600	0.33600791
84	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.32878527
85	Histidine metabolism_Homo sapiens_hsa00340	0.31629900
86	cAMP signaling pathway_Homo sapiens_hsa04024	0.29388923
87	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.28455592
88	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.25683057
89	Pancreatic secretion_Homo sapiens_hsa04972	0.25355639
90	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.25335473
91	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.23881978
92	Tight junction_Homo sapiens_hsa04530	0.23655594
93	Pentose phosphate pathway_Homo sapiens_hsa00030	0.23089927
94	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.22636296
95	Glucagon signaling pathway_Homo sapiens_hsa04922	0.19029328
96	Choline metabolism in cancer_Homo sapiens_hsa05231	0.18773610
97	Amoebiasis_Homo sapiens_hsa05146	0.17600372
98	Fatty acid elongation_Homo sapiens_hsa00062	0.15765651
99	GnRH signaling pathway_Homo sapiens_hsa04912	0.15184329
100	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.14963214

EDDM3B

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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