EDEM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of cell size (GO:0045793)7.90864597
2diaphragm development (GO:0060539)6.96440805
3negative regulation of calcium ion transport into cytosol (GO:0010523)6.72071613
4arginine catabolic process (GO:0006527)6.59742745
5pyrimidine-containing compound salvage (GO:0008655)6.33521974
6pyrimidine nucleoside salvage (GO:0043097)6.33521974
7skeletal muscle organ development (GO:0060538)5.87384383
8regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)5.69598792
9cellular protein complex localization (GO:0034629)5.67144187
10response to lipoprotein particle (GO:0055094)5.66103463
11positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)5.62284955
12pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)5.53911103
13UMP metabolic process (GO:0046049)5.53911103
14pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)5.53911103
15UMP biosynthetic process (GO:0006222)5.53911103
16negative regulation of neurotransmitter transport (GO:0051589)5.51730631
17arginine metabolic process (GO:0006525)5.20393732
18exogenous drug catabolic process (GO:0042738)5.10723834
19negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)5.01751763
203-UTR-mediated mRNA stabilization (GO:0070935)4.90145401
21positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)4.71542931
22negative regulation of vascular permeability (GO:0043116)4.71196121
23activation of MAPKKK activity (GO:0000185)4.62013433
24negative regulation of peptidyl-threonine phosphorylation (GO:0010801)4.60294741
25pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)4.41373686
26nucleotide salvage (GO:0043173)4.34853176
27L-phenylalanine catabolic process (GO:0006559)4.33526165
28erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.33526165
29intestinal cholesterol absorption (GO:0030299)4.33356733
30erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.23464682
31L-phenylalanine metabolic process (GO:0006558)4.23464682
32negative regulation of potassium ion transport (GO:0043267)4.17442760
33histone H3-K4 methylation (GO:0051568)4.13570106
34negative regulation of granulocyte differentiation (GO:0030853)4.09983413
35hypotonic response (GO:0006971)4.07556018
36nucleoside salvage (GO:0043174)4.06254203
37regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)4.05349052
38negative regulation of T cell receptor signaling pathway (GO:0050860)4.03508923
39pyrimidine nucleoside monophosphate metabolic process (GO:0009129)3.99554337
40aromatic amino acid family catabolic process (GO:0009074)3.92110364
41drug catabolic process (GO:0042737)3.90724952
42peptidyl-glutamic acid carboxylation (GO:0017187)3.89160358
43protein carboxylation (GO:0018214)3.89160358
44triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.87896123
45urea cycle (GO:0000050)3.82687882
46urea metabolic process (GO:0019627)3.82687882
47antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.82270235
48antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.82270235
49sulfur amino acid catabolic process (GO:0000098)3.79899685
50positive regulation of guanylate cyclase activity (GO:0031284)3.79883549
51Rap protein signal transduction (GO:0032486)3.79114111
52negative regulation of alcohol biosynthetic process (GO:1902931)3.75857749
53nerve growth factor signaling pathway (GO:0038180)3.71306820
54positive regulation of signal transduction by p53 class mediator (GO:1901798)3.68681601
55positive regulation of gamma-delta T cell activation (GO:0046645)3.67683166
56regulation of gamma-delta T cell differentiation (GO:0045586)3.62357064
57complement activation, alternative pathway (GO:0006957)3.58836952
58negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.58408853
59regulation of mRNA catabolic process (GO:0061013)3.57799913
60regulation of nuclear cell cycle DNA replication (GO:0033262)3.56319982
61valine metabolic process (GO:0006573)3.55896969
62cysteine metabolic process (GO:0006534)3.55281590
63antigen processing and presentation of endogenous antigen (GO:0019883)3.52374730
64positive regulation of receptor biosynthetic process (GO:0010870)3.51878286
65indole-containing compound catabolic process (GO:0042436)3.51877887
66indolalkylamine catabolic process (GO:0046218)3.51877887
67tryptophan catabolic process (GO:0006569)3.51877887
68regulation of guanylate cyclase activity (GO:0031282)3.47002355
69nitric oxide biosynthetic process (GO:0006809)3.46862580
70nitrogen cycle metabolic process (GO:0071941)3.46421346
71tryptophan metabolic process (GO:0006568)3.45625223
72kynurenine metabolic process (GO:0070189)3.45306336
73RNA stabilization (GO:0043489)3.45109547
74mRNA stabilization (GO:0048255)3.45109547
75alpha-linolenic acid metabolic process (GO:0036109)3.44261607
76negative regulation of macrophage differentiation (GO:0045650)3.43272325
77negative regulation of protein kinase B signaling (GO:0051898)3.42339246
78platelet-derived growth factor receptor signaling pathway (GO:0048008)3.41455321
79negative regulation of fibrinolysis (GO:0051918)3.39214891
80positive regulation of mRNA catabolic process (GO:0061014)3.39072602
81homocysteine metabolic process (GO:0050667)3.38019623
82antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.37659015
83regulation of cholesterol biosynthetic process (GO:0045540)3.33953604
84fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.29740360
85high-density lipoprotein particle remodeling (GO:0034375)3.29740247
86regulation of gamma-delta T cell activation (GO:0046643)3.29622837
87glyoxylate metabolic process (GO:0046487)3.28526212
88protein complex localization (GO:0031503)3.27442836
89regulation of dendritic cell antigen processing and presentation (GO:0002604)3.25946179
90regulation of protein activation cascade (GO:2000257)3.25490745
91complement activation, classical pathway (GO:0006958)3.24790740
92phospholipid homeostasis (GO:0055091)3.22508294
93regulation of protein deacetylation (GO:0090311)3.22199467
94bile acid biosynthetic process (GO:0006699)3.21472361
95adenine nucleotide transport (GO:0051503)3.19303879
96protein heterotrimerization (GO:0070208)3.17589483
97DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.17087021
98regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.16072152
99bile acid metabolic process (GO:0008206)3.13387150
100cellular response to nerve growth factor stimulus (GO:1990090)3.09808336
101response to nerve growth factor (GO:1990089)3.09808336
102phospholipid efflux (GO:0033700)3.09768164
103complement activation (GO:0006956)3.07755375
104positive regulation of DNA-dependent DNA replication (GO:2000105)3.05944616
105regulation of complement activation (GO:0030449)3.05552576
106plasma lipoprotein particle assembly (GO:0034377)3.05323409
107plasma lipoprotein particle clearance (GO:0034381)3.04351292
108regulation of neurotransmitter uptake (GO:0051580)3.02773212
109regulation of fibrinolysis (GO:0051917)3.02677473
110reverse cholesterol transport (GO:0043691)3.01729149
111regulation of T cell receptor signaling pathway (GO:0050856)3.01433360
112cholesterol efflux (GO:0033344)3.01209673
113regulation of triglyceride catabolic process (GO:0010896)2.98543291
114proline biosynthetic process (GO:0006561)2.97007559
115positive regulation of histone acetylation (GO:0035066)2.95221001
116negative regulation of sterol transport (GO:0032372)2.94846726
117negative regulation of cholesterol transport (GO:0032375)2.94846726
118regulation of stem cell maintenance (GO:2000036)2.92912910
119positive regulation of Rap GTPase activity (GO:0032854)2.92631368
120protein-lipid complex assembly (GO:0065005)2.90936887
121serine family amino acid catabolic process (GO:0009071)2.90802941
122negative regulation of interleukin-2 production (GO:0032703)2.88958910
123detection of bacterium (GO:0016045)2.87976908
124inactivation of MAPK activity (GO:0000188)2.87644700
125acylglycerol homeostasis (GO:0055090)2.87191647
126triglyceride homeostasis (GO:0070328)2.87191647
127tyrosine metabolic process (GO:0006570)2.87182196
128regulation of cholesterol homeostasis (GO:2000188)2.85489572
129regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.85417607
130maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.84353771
131macromolecular complex remodeling (GO:0034367)2.84207866
132plasma lipoprotein particle remodeling (GO:0034369)2.84207866
133protein-lipid complex remodeling (GO:0034368)2.84207866
134regulation of interferon-beta biosynthetic process (GO:0045357)2.81438848
135aromatic amino acid family metabolic process (GO:0009072)2.81403922
136detection of other organism (GO:0098543)2.80145712
137chromatin silencing (GO:0006342)2.77172962
138response to interleukin-15 (GO:0070672)2.76158404
139negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.74707148
140bile acid and bile salt transport (GO:0015721)2.74162628
141negative thymic T cell selection (GO:0045060)2.74018857
142embryonic process involved in female pregnancy (GO:0060136)2.72982401
143DNA damage response, signal transduction resulting in transcription (GO:0042772)2.72246787
144glycine metabolic process (GO:0006544)2.72114775
145cellular modified amino acid catabolic process (GO:0042219)2.72058573
146very-low-density lipoprotein particle assembly (GO:0034379)2.72040749
1474-hydroxyproline metabolic process (GO:0019471)2.71428261
148epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.71187366
149protein activation cascade (GO:0072376)2.70977422
150regulation of monocyte differentiation (GO:0045655)2.70830798
151regulation of cilium assembly (GO:1902017)2.70294282
152protein localization to endosome (GO:0036010)2.69225798
153B cell receptor signaling pathway (GO:0050853)2.66224754
154phagosome maturation (GO:0090382)2.63176823
155protein retention in ER lumen (GO:0006621)2.63097374
156regulation of granulocyte differentiation (GO:0030852)2.61538369
157COPI coating of Golgi vesicle (GO:0048205)2.60784584
158Golgi transport vesicle coating (GO:0048200)2.60784584
159immunoglobulin mediated immune response (GO:0016064)2.60609726
160positive regulation of nitric-oxide synthase activity (GO:0051000)2.60363746
161purine ribonucleotide transport (GO:0015868)2.60277385
162negative T cell selection (GO:0043383)2.60221703
163lipoprotein metabolic process (GO:0042157)2.60070019
164regulation of cell size (GO:0008361)2.59733913
165plasma lipoprotein particle organization (GO:0071827)2.59728084
166regulation of cholesterol storage (GO:0010885)2.59398515
167low-density lipoprotein particle clearance (GO:0034383)2.58563170
168intestinal absorption (GO:0050892)2.58498688
169cholesterol homeostasis (GO:0042632)2.58139307
170ncRNA 3-end processing (GO:0043628)2.57656266
171regulation of cholesterol esterification (GO:0010872)2.57341458
172acute-phase response (GO:0006953)2.56896869
173establishment of endothelial barrier (GO:0061028)2.56509312
174negative regulation of fatty acid biosynthetic process (GO:0045717)2.56206633
175sterol homeostasis (GO:0055092)2.56145203
176cytolysis (GO:0019835)2.56001169
177serine family amino acid metabolic process (GO:0009069)2.55413583
178positive regulation of cell junction assembly (GO:1901890)2.55335522
179protein-lipid complex subunit organization (GO:0071825)2.54316254
180ethanol oxidation (GO:0006069)2.53737854
181cholesterol transport (GO:0030301)2.53087887
182sterol transport (GO:0015918)2.53087887
183mannose metabolic process (GO:0006013)2.52973177
184proline metabolic process (GO:0006560)2.52290845
185serine family amino acid biosynthetic process (GO:0009070)2.52007553
186benzene-containing compound metabolic process (GO:0042537)2.51863919
187COPII vesicle coating (GO:0048208)2.51527968
188positive regulation by symbiont of host defense response (GO:0052509)2.51064018
189modulation by symbiont of host defense response (GO:0052031)2.51064018
190modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.51064018
191positive regulation by organism of defense response of other organism involved in symbiotic interact2.51064018
192modulation by symbiont of host immune response (GO:0052553)2.51064018

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.66606570
2* ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.60195754
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human5.33741760
4* RXR_22158963_ChIP-Seq_LIVER_Mouse4.30315932
5IRF8_22096565_ChIP-ChIP_GC-B_Human4.20037288
6* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.96147941
7* LXR_22158963_ChIP-Seq_LIVER_Mouse3.53766996
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.27522351
9EGR1_23403033_ChIP-Seq_LIVER_Mouse2.99797894
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.75475609
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.73143818
12BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.66670498
13CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.65496142
14FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.65216683
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.60268620
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.53914076
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.51690160
18PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.48934322
19STAT6_21828071_ChIP-Seq_BEAS2B_Human2.42211270
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.40260034
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.31445218
22* IRF8_27001747_Chip-Seq_BMDM_Mouse2.30237698
23MYC_22102868_ChIP-Seq_BL_Human2.21147672
24* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.20309120
25ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse2.18564205
26CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.16246753
27IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.13626985
28* IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.11009606
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.08212754
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.03545414
31NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.99425351
32MYB_21317192_ChIP-Seq_ERMYB_Mouse1.99408117
33VDR_21846776_ChIP-Seq_THP-1_Human1.98244511
34BRD4_27068464_Chip-Seq_AML-cells_Mouse1.91663630
35VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.89463718
36SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.86873216
37STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.80715449
38NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.77225699
39Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.73936449
40* MAF_26560356_Chip-Seq_TH1_Human1.68201596
41RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.67219499
42* MYB_26560356_Chip-Seq_TH2_Human1.67066880
43E2F7_22180533_ChIP-Seq_HELA_Human1.66153048
44SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.65259510
45MYB_26560356_Chip-Seq_TH1_Human1.64113927
46STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.63897361
47GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.61388284
48* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.58863266
49* RUNX_20019798_ChIP-Seq_JUKART_Human1.58064407
50CLOCK_20551151_ChIP-Seq_293T_Human1.56495471
51* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.54361733
52KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.51507397
53* UTX_26944678_Chip-Seq_JUKART_Human1.51018680
54* VDR_24763502_ChIP-Seq_THP-1_Human1.49093258
55TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47920882
56ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.47568233
57TCF7_22412390_ChIP-Seq_EML_Mouse1.47190945
58RUNX1_22412390_ChIP-Seq_EML_Mouse1.43879973
59RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.40190366
60SCL_19346495_ChIP-Seq_HPC-7_Human1.36842207
61FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.35505412
62STAT4_19710469_ChIP-ChIP_TH1__Mouse1.34965174
63SPI1_23547873_ChIP-Seq_NB4_Human1.34674936
64TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.33634347
65GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32745122
66GATA1_19941827_ChIP-Seq_MEL_Mouse1.27948082
67TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.20705349
68KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.18928006
69PU_27001747_Chip-Seq_BMDM_Mouse1.18828830
70TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.17877123
71* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.16552424
72* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.16050427
73CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.13893165
74* GATA3_27048872_Chip-Seq_THYMUS_Human1.13855849
75SOX2_27498859_Chip-Seq_STOMACH_Mouse1.13498890
76GATA1_19941826_ChIP-Seq_K562_Human1.13310582
77NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12101435
78* KDM2B_26808549_Chip-Seq_DND41_Human1.10315230
79* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09988298
80KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09909725
81* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.09708110
82ELK3_25401928_ChIP-Seq_HUVEC_Human1.08802674
83TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08182415
84CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08012691
85VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.06698016
86FOXM1_23109430_ChIP-Seq_U2OS_Human1.06051011
87GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05918240
88MAF_26560356_Chip-Seq_TH2_Human1.04244913
89AHR_22903824_ChIP-Seq_MCF-7_Human1.04137675
90SMC4_20622854_ChIP-Seq_HELA_Human1.03545115
91GATA1_22025678_ChIP-Seq_K562_Human1.03492598
92SPI1_23127762_ChIP-Seq_K562_Human1.01535302
93GATA6_25053715_ChIP-Seq_YYC3_Human1.01445994
94JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00266840
95THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.00264363
96BP1_19119308_ChIP-ChIP_Hs578T_Human1.00055237
97* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99874075
98JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98743660
99VDR_24787735_ChIP-Seq_THP-1_Human0.98656978
100TFEB_21752829_ChIP-Seq_HELA_Human0.97786591
101SMAD_19615063_ChIP-ChIP_OVARY_Human0.97119771
102FOXA2_19822575_ChIP-Seq_HepG2_Human0.97016818
103MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.96242636
104ELK4_26923725_Chip-Seq_MESODERM_Mouse0.95939963
105* LXR_22292898_ChIP-Seq_THP-1_Human0.95546515
106KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95421032
107FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.95303339
108FOXO3_23340844_ChIP-Seq_DLD1_Human0.95246507
109GATA2_21666600_ChIP-Seq_HMVEC_Human0.94559147
110CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94475329
111ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.92024397
112TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.91865442
113* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91177167
114RACK7_27058665_Chip-Seq_MCF-7_Human0.90474941
115GATA4_25053715_ChIP-Seq_YYC3_Human0.88193099
116KDM2B_26808549_Chip-Seq_K562_Human0.87327400
117SMRT_27268052_Chip-Seq_Bcells_Human0.87147920
118NCOR1_26117541_ChIP-Seq_K562_Human0.86953060
119KDM2B_26808549_Chip-Seq_SUP-B15_Human0.85648471
120CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84633905
121CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84601739
122TBX20_22080862_ChIP-Seq_HEART_Mouse0.84330744
123TBX20_22328084_ChIP-Seq_HEART_Mouse0.84330744
124KDM2B_26808549_Chip-Seq_JURKAT_Human0.83779910
125* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.83489618
126PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83317735
127* GATA3_26560356_Chip-Seq_TH2_Human0.82947275
128TP63_17297297_ChIP-ChIP_HaCaT_Human0.82554026
129RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.82234614
130PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81830658
131PU.1_20513432_ChIP-Seq_Bcells_Mouse0.81169413
132* HNF4A_19822575_ChIP-Seq_HepG2_Human0.80872159
133NFIB_24661679_ChIP-Seq_LUNG_Mouse0.78025455
134SOX9_24532713_ChIP-Seq_HFSC_Mouse0.77061365
135* GATA2_19941826_ChIP-Seq_K562_Human0.77057690
136SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.76903254

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue5.89950857
2MP0000566_synostosis5.02850106
3MP0002139_abnormal_hepatobiliary_system4.21780934
4MP0005365_abnormal_bile_salt4.18172865
5MP0005360_urolithiasis4.00095427
6MP0002234_abnormal_pharynx_morphology3.64490836
7MP0005167_abnormal_blood-brain_barrier3.60213796
8MP0004233_abnormal_muscle_weight3.55135181
9MP0005085_abnormal_gallbladder_physiolo3.47416004
10MP0004043_abnormal_pH_regulation3.43320202
11MP0010368_abnormal_lymphatic_system3.37778101
12MP0005645_abnormal_hypothalamus_physiol3.26033900
13MP0004858_abnormal_nervous_system3.20152641
14MP0003045_fibrosis2.85871717
15MP0001666_abnormal_nutrient_absorption2.53096849
16MP0002009_preneoplasia2.53012911
17MP0005083_abnormal_biliary_tract2.49410936
18MP0003252_abnormal_bile_duct2.43971341
19MP0009840_abnormal_foam_cell2.33344833
20MP0001835_abnormal_antigen_presentation2.32645541
21MP0008875_abnormal_xenobiotic_pharmacok2.22384188
22MP0003191_abnormal_cellular_cholesterol2.22373848
23MP0005058_abnormal_lysosome_morphology2.21898176
24MP0002166_altered_tumor_susceptibility2.16334415
25MP0010329_abnormal_lipoprotein_level2.03682744
26MP0004084_abnormal_cardiac_muscle2.03641699
27MP0003436_decreased_susceptibility_to2.03308533
28MP0003300_gastrointestinal_ulcer1.95609577
29MP0009053_abnormal_anal_canal1.94705898
30MP0003303_peritoneal_inflammation1.94246207
31MP0000685_abnormal_immune_system1.89523584
32MP0006082_CNS_inflammation1.87627431
33MP0000609_abnormal_liver_physiology1.78899419
34MP0005387_immune_system_phenotype1.72703931
35MP0001790_abnormal_immune_system1.72703931
36MP0003806_abnormal_nucleotide_metabolis1.68711678
37MP0003705_abnormal_hypodermis_morpholog1.68183868
38MP0005464_abnormal_platelet_physiology1.67567281
39MP0002396_abnormal_hematopoietic_system1.67474818
40MP0001800_abnormal_humoral_immune1.66909112
41MP0005671_abnormal_response_to1.66393095
42MP0002138_abnormal_hepatobiliary_system1.62954560
43MP0002419_abnormal_innate_immunity1.56001626
44MP0002006_tumorigenesis1.53360178
45MP0003172_abnormal_lysosome_physiology1.51281307
46MP0004947_skin_inflammation1.49650132
47MP0003283_abnormal_digestive_organ1.47924586
48MP0005025_abnormal_response_to1.47620678
49MP0009785_altered_susceptibility_to1.46340087
50MP0005000_abnormal_immune_tolerance1.45689140
51MP0010155_abnormal_intestine_physiology1.45568250
52MP0003763_abnormal_thymus_physiology1.44218121
53MP0002452_abnormal_antigen_presenting1.43503992
54MP0003868_abnormal_feces_composition1.40784499
55MP0001919_abnormal_reproductive_system1.40694774
56MP0002723_abnormal_immune_serum1.39885813
57MP0001845_abnormal_inflammatory_respons1.39445254
58MP0009278_abnormal_bone_marrow1.37241661
59MP0004883_abnormal_blood_vessel1.35499384
60MP0000467_abnormal_esophagus_morphology1.34912862
61MP0005332_abnormal_amino_acid1.34424086
62MP0005220_abnormal_exocrine_pancreas1.33250456
63MP0002118_abnormal_lipid_homeostasis1.31525738
64MP0002420_abnormal_adaptive_immunity1.27896703
65MP0003075_altered_response_to1.27549475
66MP0000733_abnormal_muscle_development1.27528686
67MP0008469_abnormal_protein_level1.27371544
68MP0001819_abnormal_immune_cell1.26890126
69MP0002405_respiratory_system_inflammati1.26660898
70MP0005319_abnormal_enzyme/_coenzyme1.19360016
71MP0000767_abnormal_smooth_muscle1.18572231
72MP0000689_abnormal_spleen_morphology1.17695035
73MP0002398_abnormal_bone_marrow1.17383024
74MP0000598_abnormal_liver_morphology1.15222380
75MP0000716_abnormal_immune_system1.15053993
76MP0003724_increased_susceptibility_to1.14079994
77MP0010234_abnormal_vibrissa_follicle1.11056551
78MP0004019_abnormal_vitamin_homeostasis1.08718794
79MP0004264_abnormal_extraembryonic_tissu1.08674307
80MP0005166_decreased_susceptibility_to1.07732453
81MP0001501_abnormal_sleep_pattern1.07702153
82MP0003195_calcinosis1.07389334
83MP0002148_abnormal_hypersensitivity_rea1.07252733
84MP0002722_abnormal_immune_system1.07043281
85MP0001873_stomach_inflammation1.06416707
86MP0003183_abnormal_peptide_metabolism1.06133179
87MP0005076_abnormal_cell_differentiation1.05500333
88MP0005397_hematopoietic_system_phenotyp1.04889952
89MP0001545_abnormal_hematopoietic_system1.04889952
90MP0009333_abnormal_splenocyte_physiolog1.04357188
91MP0001853_heart_inflammation1.04348721
92MP0009643_abnormal_urine_homeostasis1.03359496
93MP0003718_maternal_effect1.03359340
94MP0004036_abnormal_muscle_relaxation1.02751923
95MP0000470_abnormal_stomach_morphology1.00804521
96MP0009763_increased_sensitivity_to0.96747704
97MP0001533_abnormal_skeleton_physiology0.96466608
98MP0002429_abnormal_blood_cell0.95921661
99MP0010352_gastrointestinal_tract_polyps0.95646950
100MP0003656_abnormal_erythrocyte_physiolo0.95460199
101MP0004484_altered_response_of0.95242267
102MP0003453_abnormal_keratinocyte_physiol0.95061507
103MP0001879_abnormal_lymphatic_vessel0.94262700
104MP0000703_abnormal_thymus_morphology0.94139615
105MP0005584_abnormal_enzyme/coenzyme_acti0.92731250
106MP0000371_diluted_coat_color0.92602222
107MP0003448_altered_tumor_morphology0.91728295
108MP0009764_decreased_sensitivity_to0.91214942
109MP0003091_abnormal_cell_migration0.89605488
110MP0008872_abnormal_physiological_respon0.88593932
111MP0002168_other_aberrant_phenotype0.88340164
112MP0004185_abnormal_adipocyte_glucose0.88331515
113MP0005164_abnormal_response_to0.87904938
114MP0001764_abnormal_homeostasis0.87767454
115MP0002132_abnormal_respiratory_system0.87562938
116MP0006138_congestive_heart_failure0.85101920
117MP0005023_abnormal_wound_healing0.85091447
118MP0000569_abnormal_digit_pigmentation0.84820407
119MP0005310_abnormal_salivary_gland0.82908304
120MP0005451_abnormal_body_composition0.82673399
121MP0008775_abnormal_heart_ventricle0.82472532
122MP0001664_abnormal_digestion0.82325430
123MP0002933_joint_inflammation0.81864072
124MP0005408_hypopigmentation0.80508015
125MP0010307_abnormal_tumor_latency0.80220124
126MP0003186_abnormal_redox_activity0.79642649
127MP0005174_abnormal_tail_pigmentation0.79243840
128MP0003566_abnormal_cell_adhesion0.79089515
129MP0002928_abnormal_bile_duct0.77522961
130MP0000858_altered_metastatic_potential0.77357389
131MP0010678_abnormal_skin_adnexa0.76037791
132MP0000604_amyloidosis0.76001148
133MP0000490_abnormal_crypts_of0.74787243
134MP0001663_abnormal_digestive_system0.74413515
135MP0003828_pulmonary_edema0.72706614
136MP0004130_abnormal_muscle_cell0.72526276
137MP0002998_abnormal_bone_remodeling0.72088978
138MP0002136_abnormal_kidney_physiology0.71186342
139MP0008260_abnormal_autophagy0.70306798
140MP0000383_abnormal_hair_follicle0.69171632
141MP0009765_abnormal_xenobiotic_induced0.68851759
142MP0000015_abnormal_ear_pigmentation0.65469335
143MP0002113_abnormal_skeleton_development0.64519098
144MP0005197_abnormal_uvea_morphology0.61014008
145MP0004808_abnormal_hematopoietic_stem0.58674917
146MP0002127_abnormal_cardiovascular_syste0.57088878
147MP0000477_abnormal_intestine_morphology0.55340384

Predicted human phenotypes

RankGene SetZ-score
1Lip pit (HP:0100267)7.30533566
2Sparse lateral eyebrow (HP:0005338)7.14127492
3Anal stenosis (HP:0002025)6.33497375
4Abnormality of the fingertips (HP:0001211)6.33208342
5Ureteral stenosis (HP:0000071)5.58534005
6Depressed nasal tip (HP:0000437)5.40596815
7Intestinal fistula (HP:0100819)5.26011176
8Ureteral obstruction (HP:0006000)5.25995840
9Lower limb hyperreflexia (HP:0002395)4.56668770
10Short 5th finger (HP:0009237)4.43974013
11Deep venous thrombosis (HP:0002625)4.28999893
12Aplasia/Hypoplasia of the 5th finger (HP:0006262)4.04227151
13Myocardial infarction (HP:0001658)3.89976712
14Complement deficiency (HP:0004431)3.89358488
15Abnormality of aromatic amino acid family metabolism (HP:0004338)3.86493875
16Intrahepatic cholestasis (HP:0001406)3.83153387
17Increased CSF protein (HP:0002922)3.81197467
18Popliteal pterygium (HP:0009756)3.76798997
19Abnormality of monocarboxylic acid metabolism (HP:0010996)3.69758904
20Xanthomatosis (HP:0000991)3.68068422
21Abnormality of the common coagulation pathway (HP:0010990)3.66351686
22T lymphocytopenia (HP:0005403)3.63218112
23Prolonged partial thromboplastin time (HP:0003645)3.62583021
24Joint hemorrhage (HP:0005261)3.58055713
25Recurrent viral infections (HP:0004429)3.56672787
26Abnormality of T cell number (HP:0011839)3.54862773
27B lymphocytopenia (HP:0010976)3.53223353
28Abnormality of B cell number (HP:0010975)3.53223353
29Recurrent gram-negative bacterial infections (HP:0005420)3.53087831
30Fatigue (HP:0012378)3.45637402
31Ectropion (HP:0000656)3.44167424
32Systemic lupus erythematosus (HP:0002725)3.35629177
33Hypobetalipoproteinemia (HP:0003563)3.33868272
34Posterior subcapsular cataract (HP:0007787)3.32074421
35Hypoplasia of the thymus (HP:0000778)3.31277282
36Long palpebral fissure (HP:0000637)3.22627481
37Recurrent bacterial skin infections (HP:0005406)3.20848890
38Abnormality of the intrinsic pathway (HP:0010989)3.19225485
39Abnormality of complement system (HP:0005339)3.15673034
40Eczematoid dermatitis (HP:0000976)3.14807661
41Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.07598468
42Vertebral hypoplasia (HP:0008417)3.07598468
43Fat malabsorption (HP:0002630)3.07225387
44Ectopic kidney (HP:0000086)3.03089679
45Recurrent abscess formation (HP:0002722)3.00043484
46Recurrent fungal infections (HP:0002841)2.95909661
47Hyperlipoproteinemia (HP:0010980)2.95695530
48Vacuolated lymphocytes (HP:0001922)2.93548112
49Dysostosis multiplex (HP:0000943)2.84267520
50Natal tooth (HP:0000695)2.84131635
51Colitis (HP:0002583)2.83515659
52Abnormality of sulfur amino acid metabolism (HP:0004339)2.79769088
53Pustule (HP:0200039)2.77972360
54Mucopolysacchariduria (HP:0008155)2.75922937
55Urinary glycosaminoglycan excretion (HP:0003541)2.75922937
56Abnormality of glutamine family amino acid metabolism (HP:0010902)2.73867580
57Gingival bleeding (HP:0000225)2.72171180
58Thyroiditis (HP:0100646)2.72059949
59Eosinophilia (HP:0001880)2.70590118
60Glomerulonephritis (HP:0000099)2.63298318
61Recurrent otitis media (HP:0000403)2.62167994
62Conjugated hyperbilirubinemia (HP:0002908)2.61577500
63Steatorrhea (HP:0002570)2.60497396
64Epidermoid cyst (HP:0200040)2.59777794
65Abnormality of the periventricular white matter (HP:0002518)2.59679903
66Hypolipoproteinemia (HP:0010981)2.56834390
67Asymmetry of the thorax (HP:0001555)2.56780986
68Abnormality of polysaccharide metabolism (HP:0011012)2.56546119
69Abnormality of glycosaminoglycan metabolism (HP:0004371)2.56546119
70Abnormality of mucopolysaccharide metabolism (HP:0011020)2.56546119
71Severe combined immunodeficiency (HP:0004430)2.54599760
72Combined immunodeficiency (HP:0005387)2.49570752
73Preauricular pit (HP:0004467)2.49302640
74Periauricular skin pits (HP:0100277)2.49302640
75Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.46483636
76Abnormal platelet volume (HP:0011876)2.46422110
77Menorrhagia (HP:0000132)2.45401119
78Abnormal delayed hypersensitivity skin test (HP:0002963)2.45146263
79Transitional cell carcinoma of the bladder (HP:0006740)2.44392592
80Autoimmune thrombocytopenia (HP:0001973)2.43357603
81Panhypogammaglobulinemia (HP:0003139)2.42967837
82Abnormality of the distal phalanges of the toes (HP:0010182)2.42588530
83Inflammation of the large intestine (HP:0002037)2.42198008
84Progressive neurologic deterioration (HP:0002344)2.41383115
85Hypercholesterolemia (HP:0003124)2.39972036
86Abnormality of T cells (HP:0002843)2.39725853
87Narrow palate (HP:0000189)2.38526998
88Uterine leiomyosarcoma (HP:0002891)2.37125407
89Leiomyosarcoma (HP:0100243)2.37125407
90Increased mean platelet volume (HP:0011877)2.35879925
91Renal cell carcinoma (HP:0005584)2.33339991
92Granulocytopenia (HP:0001913)2.30599699
93Gastrointestinal inflammation (HP:0004386)2.30269745
94Hypoalphalipoproteinemia (HP:0003233)2.29516030
95Recurrent skin infections (HP:0001581)2.27920268
96Ketosis (HP:0001946)2.27685719
97Esophageal varix (HP:0002040)2.27468223
98Bladder carcinoma (HP:0002862)2.26142724
99Bladder neoplasm (HP:0009725)2.26142724
100Hyperammonemia (HP:0001987)2.25018822
101Emphysema (HP:0002097)2.22169246
102Mask-like facies (HP:0000298)2.18986564
103Abnormality of methionine metabolism (HP:0010901)2.18596091
104Periodontitis (HP:0000704)2.17008079
105Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.15873924
106Hypoglycemic coma (HP:0001325)2.13939632
107Abnormality of aspartate family amino acid metabolism (HP:0010899)2.11261346
108Nephritis (HP:0000123)2.11250429
109Self-mutilation (HP:0000742)2.10445960
110Spontaneous hematomas (HP:0007420)2.10308677
111Pheochromocytoma (HP:0002666)2.09867758
112Epistaxis (HP:0000421)2.09060494
113Hypochromic microcytic anemia (HP:0004840)2.05809028
114Wide intermamillary distance (HP:0006610)2.03639585
115Meningitis (HP:0001287)2.02952352
116Hematochezia (HP:0002573)2.02697672
117Abnormality of pyrimidine metabolism (HP:0004353)2.02655686
118Neonatal short-limb short stature (HP:0008921)2.01787087
119Abnormality of eosinophils (HP:0001879)2.00654531
120Hepatocellular carcinoma (HP:0001402)1.99988922
121Abnormality of macrophages (HP:0004311)1.98997866
122Neonatal death (HP:0003811)1.98213430
123Leukocytosis (HP:0001974)1.97401865
124Pulmonary infiltrates (HP:0002113)1.96252427
125Mitral stenosis (HP:0001718)1.96141241
126Agammaglobulinemia (HP:0004432)1.94962230
127Elevated erythrocyte sedimentation rate (HP:0003565)1.93844406
128Thrombophlebitis (HP:0004418)1.93469337
129Abnormal foot bone ossification (HP:0010675)1.93234896
130Coarse hair (HP:0002208)1.92804171
131Pulmonary embolism (HP:0002204)1.92762173
132Arterial thrombosis (HP:0004420)1.91472922
133Vascular calcification (HP:0004934)1.90893793
134Blue irides (HP:0000635)1.90445629
135Myositis (HP:0100614)1.88575279
136Hydroxyprolinuria (HP:0003080)1.88480024
137Abnormality of proline metabolism (HP:0010907)1.88480024
138Increased cerebral lipofuscin (HP:0011813)1.88236626
139Trismus (HP:0000211)1.86958536
140Vasculitis (HP:0002633)1.86884212
141Abnormality of nucleobase metabolism (HP:0010932)1.85879094
142Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.85096349
143Hyperglycinuria (HP:0003108)1.84356598
144Tubulointerstitial fibrosis (HP:0005576)1.82729555
145Abnormality of transition element cation homeostasis (HP:0011030)1.82409429
146Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.81738268
147Axonal loss (HP:0003447)1.81725806
148Hypochromic anemia (HP:0001931)1.81207743
149Gastrointestinal infarctions (HP:0005244)1.81091912
150Gingivitis (HP:0000230)1.80780414
151Pancreatitis (HP:0001733)1.80639682
152Cerebral hemorrhage (HP:0001342)1.80621606
153Abnormal platelet function (HP:0011869)1.80185012
154Recurrent cutaneous fungal infections (HP:0011370)1.79096860
155Chronic mucocutaneous candidiasis (HP:0002728)1.79096860
156Gastrointestinal stroma tumor (HP:0100723)1.78991647
157Neuroendocrine neoplasm (HP:0100634)1.74316809
158Subcapsular cataract (HP:0000523)1.74243204
159Absent eyebrow (HP:0002223)1.73253078
160Congenital hip dislocation (HP:0001374)1.73226408
161Chronic diarrhea (HP:0002028)1.72638426
162Absent eyelashes (HP:0000561)1.72423751
163Reduced subcutaneous adipose tissue (HP:0003758)1.72302843
164Optic neuritis (HP:0100653)1.72117108
165Retrobulbar optic neuritis (HP:0100654)1.72117108
166Frequent falls (HP:0002359)1.71222768
167Generalized aminoaciduria (HP:0002909)1.70650995
168Fibular aplasia (HP:0002990)1.67903869
169Polycythemia (HP:0001901)1.67688627
170Autoimmune hemolytic anemia (HP:0001890)1.64603999
171Facial cleft (HP:0002006)1.63784472
172Abnormal tarsal ossification (HP:0008369)1.63484018
173Acute hepatic failure (HP:0006554)1.62996968
174Peripheral demyelination (HP:0011096)1.62964194
175Broad thumb (HP:0011304)1.62905448
176Poor head control (HP:0002421)1.62885641
177Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.62435915
178Tinnitus (HP:0000360)1.62024331
179Hypertensive crisis (HP:0100735)1.61651338
180Gastrointestinal carcinoma (HP:0002672)1.61496591
181Malignant gastrointestinal tract tumors (HP:0006749)1.61496591
182Hemoptysis (HP:0002105)1.61066839
183Abnormality of T cell physiology (HP:0011840)1.61065592

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK248.46007835
2STK394.46820060
3WNK44.39172154
4ERN14.08694009
5CCNB14.03812562
6MAP3K24.02341261
7MAP4K13.03111964
8TYK22.84993410
9PINK12.68074669
10TRIB32.66235552
11TAOK32.63092700
12PKN22.43184652
13FGFR42.23714532
14MAPKAPK32.08724923
15WNK12.01886546
16TXK2.01161555
17BCKDK1.97911201
18ILK1.94165277
19MAP3K141.93841022
20CSK1.93241353
21STK101.89811355
22ZAP701.88440343
23SIK11.85529957
24PRPF4B1.81778441
25JAK31.80246807
26MAP3K101.78595973
27JAK11.75885657
28TBK11.75639479
29EEF2K1.75259509
30CDK121.71205963
31IRAK41.70687961
32IRAK31.67744284
33FRK1.67642218
34PTK61.63139327
35TGFBR21.53148682
36FLT31.51156452
37GRK61.49952780
38ITK1.44180343
39CDK61.43964998
40NEK91.43416568
41FGFR31.37374327
42CSF1R1.33359705
43ZAK1.31887141
44CAMK41.30372291
45EPHB11.22892708
46SCYL21.21273352
47JAK21.21222161
48IKBKE1.20376401
49CAMKK21.19337739
50MAP2K31.17273187
51SYK1.13758634
52CAMK1D1.13164950
53BTK1.10866184
54CAMK11.08807994
55LRRK21.05879959
56KIT1.04700362
57PIM11.03848549
58MAPK151.03527791
59PDGFRB1.03322217
60LCK1.03180787
61TRPM71.00534036
62CHEK20.99238914
63HCK0.97062187
64MAPK110.96226763
65MAP3K110.93552618
66IKBKB0.92826926
67PDGFRA0.90772709
68TEC0.88583776
69BLK0.88452389
70YES10.86068046
71MAPKAPK50.85642283
72PASK0.84902020
73CHUK0.80992247
74DYRK1B0.80703135
75MAP3K60.79883772
76BMX0.78886121
77ICK0.77253435
78CDK90.76271502
79LYN0.74469944
80CDK40.72724651
81RPS6KA40.72416455
82RIPK10.67952185
83EIF2AK30.67277866
84MST1R0.67151520
85FGR0.65781039
86MTOR0.65478781
87INSRR0.63771944
88EGFR0.61020512
89TNK20.60866223
90PIK3CG0.60405995
91STK30.59360676
92MATK0.56722726
93MAP3K80.56606766
94GSK3A0.56332998
95BMPR20.56291158
96MAPK40.56219395
97PRKCQ0.55909980
98MELK0.55867024
99TTN0.54208090
100MAP3K30.54095921
101CAMKK10.52361619
102SGK30.52090114
103HIPK20.51772838
104MAP3K70.51058588
105RPS6KA60.50440532
106PRKCH0.49742149
107CAMK1G0.49605887
108MARK30.49492409
109RPS6KA20.49435658
110RPS6KC10.49137724
111RPS6KL10.49137724
112NME20.48775404
113STK40.48198643
114RIPK40.47126147
115LATS10.47052837
116MAPK70.46320634
117ABL10.46169690
118PRKAA20.45973925
119RPS6KB20.45962545
120MAP3K130.43305960
121MST40.40151096
122MAPKAPK20.40032971
123SIK30.39353436
124INSR0.39327696
125ACVR1B0.36893164
126NTRK20.34274675
127MAPK120.33410203
128CDC70.33221815
129EIF2AK20.29408276
130IRAK10.29151271
131FER0.27947980
132TTK0.27072554
133DAPK20.26274904
134PDK10.20779932
135SGK20.20284120
136IRAK20.18602231
137PRKCD0.17737594
138TGFBR10.14862194
139RPS6KB10.14258046
140BMPR1B0.11009218
141CDC42BPA0.10997345
142SRPK10.10421572

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.27022331
2Allograft rejection_Homo sapiens_hsa053303.10469031
3Graft-versus-host disease_Homo sapiens_hsa053322.92283937
4Autoimmune thyroid disease_Homo sapiens_hsa053202.90086900
5Staphylococcus aureus infection_Homo sapiens_hsa051502.81228616
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.73424348
7Asthma_Homo sapiens_hsa053102.69288577
8Nitrogen metabolism_Homo sapiens_hsa009102.50421931
9Complement and coagulation cascades_Homo sapiens_hsa046102.47962226
10Type I diabetes mellitus_Homo sapiens_hsa049402.47643837
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.34064480
12Arginine biosynthesis_Homo sapiens_hsa002202.23934855
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.14547711
14Primary immunodeficiency_Homo sapiens_hsa053401.98205156
15Tryptophan metabolism_Homo sapiens_hsa003801.92105238
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.74876715
17Caffeine metabolism_Homo sapiens_hsa002321.72808736
18Fatty acid degradation_Homo sapiens_hsa000711.72742974
19Fat digestion and absorption_Homo sapiens_hsa049751.61344292
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.55830577
21Selenocompound metabolism_Homo sapiens_hsa004501.51270041
22AMPK signaling pathway_Homo sapiens_hsa041521.49141270
23Viral myocarditis_Homo sapiens_hsa054161.47013085
24PPAR signaling pathway_Homo sapiens_hsa033201.42777527
25Rheumatoid arthritis_Homo sapiens_hsa053231.41754439
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.40991383
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.36698270
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.33172783
29Peroxisome_Homo sapiens_hsa041461.30117204
30Histidine metabolism_Homo sapiens_hsa003401.29734407
31Fatty acid metabolism_Homo sapiens_hsa012121.29360964
32Lysine degradation_Homo sapiens_hsa003101.26960741
33Glycosaminoglycan degradation_Homo sapiens_hsa005311.26675076
34Intestinal immune network for IgA production_Homo sapiens_hsa046721.25674071
35Phagosome_Homo sapiens_hsa041451.24011495
36ABC transporters_Homo sapiens_hsa020101.22408627
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.20029513
38Starch and sucrose metabolism_Homo sapiens_hsa005001.19324115
39Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.19265563
40One carbon pool by folate_Homo sapiens_hsa006701.17727900
41Sphingolipid signaling pathway_Homo sapiens_hsa040711.17173504
42Renal cell carcinoma_Homo sapiens_hsa052111.15726330
43beta-Alanine metabolism_Homo sapiens_hsa004101.15642837
44Antigen processing and presentation_Homo sapiens_hsa046121.15105811
45Other glycan degradation_Homo sapiens_hsa005111.14375843
46* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.14246273
47Leishmaniasis_Homo sapiens_hsa051401.13204585
48Folate biosynthesis_Homo sapiens_hsa007901.12535249
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.12252347
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.12023465
51NF-kappa B signaling pathway_Homo sapiens_hsa040641.08844918
52Chemical carcinogenesis_Homo sapiens_hsa052041.07611487
53B cell receptor signaling pathway_Homo sapiens_hsa046621.06987605
54African trypanosomiasis_Homo sapiens_hsa051431.05325038
55Neurotrophin signaling pathway_Homo sapiens_hsa047221.01434722
56Steroid hormone biosynthesis_Homo sapiens_hsa001401.01404151
57Fatty acid biosynthesis_Homo sapiens_hsa000611.01214643
58Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.00889709
59Propanoate metabolism_Homo sapiens_hsa006401.00315040
60Glycerolipid metabolism_Homo sapiens_hsa005611.00168935
61Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.99762018
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.99727469
63Osteoclast differentiation_Homo sapiens_hsa043800.99239366
64Lysosome_Homo sapiens_hsa041420.98139587
65Measles_Homo sapiens_hsa051620.95578750
66Malaria_Homo sapiens_hsa051440.91484526
67Non-homologous end-joining_Homo sapiens_hsa034500.87770854
68Chemokine signaling pathway_Homo sapiens_hsa040620.87657266
69Steroid biosynthesis_Homo sapiens_hsa001000.87194864
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.86581958
71Legionellosis_Homo sapiens_hsa051340.86077346
72T cell receptor signaling pathway_Homo sapiens_hsa046600.84436677
73mTOR signaling pathway_Homo sapiens_hsa041500.81977050
74Toll-like receptor signaling pathway_Homo sapiens_hsa046200.81351937
752-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.81158013
76Retinol metabolism_Homo sapiens_hsa008300.80842527
77Phenylalanine metabolism_Homo sapiens_hsa003600.79215132
78Sulfur metabolism_Homo sapiens_hsa009200.77332066
79Biosynthesis of amino acids_Homo sapiens_hsa012300.76552821
80Bile secretion_Homo sapiens_hsa049760.75873196
81Sulfur relay system_Homo sapiens_hsa041220.75730098
82Vitamin digestion and absorption_Homo sapiens_hsa049770.74286900
83Acute myeloid leukemia_Homo sapiens_hsa052210.73135795
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.72302455
85Glioma_Homo sapiens_hsa052140.71727225
86Non-small cell lung cancer_Homo sapiens_hsa052230.70670289
87RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.69998440
88Systemic lupus erythematosus_Homo sapiens_hsa053220.69486353
89Hematopoietic cell lineage_Homo sapiens_hsa046400.68703872
90Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.67884530
91Insulin signaling pathway_Homo sapiens_hsa049100.67163096
92Insulin resistance_Homo sapiens_hsa049310.65977048
93AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64844252
94Toxoplasmosis_Homo sapiens_hsa051450.64603639
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63916502
96Chronic myeloid leukemia_Homo sapiens_hsa052200.63114325
97Influenza A_Homo sapiens_hsa051640.62779331
98Arginine and proline metabolism_Homo sapiens_hsa003300.62154422
99Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.62097792
100Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.61813960
101Small cell lung cancer_Homo sapiens_hsa052220.61637489
102Pertussis_Homo sapiens_hsa051330.60418869
103Renin-angiotensin system_Homo sapiens_hsa046140.60316690
104Butanoate metabolism_Homo sapiens_hsa006500.59767383
105Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58867843
106Dorso-ventral axis formation_Homo sapiens_hsa043200.58363114
107Cyanoamino acid metabolism_Homo sapiens_hsa004600.56979635
108Tyrosine metabolism_Homo sapiens_hsa003500.56819780
109Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56600322
110Apoptosis_Homo sapiens_hsa042100.56166400
111Tuberculosis_Homo sapiens_hsa051520.56048492
112N-Glycan biosynthesis_Homo sapiens_hsa005100.55134309
113p53 signaling pathway_Homo sapiens_hsa041150.53414308
114Hepatitis C_Homo sapiens_hsa051600.52744336
115Epstein-Barr virus infection_Homo sapiens_hsa051690.52304604
116HTLV-I infection_Homo sapiens_hsa051660.51941393
117Jak-STAT signaling pathway_Homo sapiens_hsa046300.51902018
118Prion diseases_Homo sapiens_hsa050200.51195701
119Endocytosis_Homo sapiens_hsa041440.49935756
120Leukocyte transendothelial migration_Homo sapiens_hsa046700.49489048
121Cysteine and methionine metabolism_Homo sapiens_hsa002700.48738870
122Hepatitis B_Homo sapiens_hsa051610.48252822
123Viral carcinogenesis_Homo sapiens_hsa052030.48235544
124Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47721573
125Herpes simplex infection_Homo sapiens_hsa051680.47179294
126Pentose phosphate pathway_Homo sapiens_hsa000300.46144924
127TGF-beta signaling pathway_Homo sapiens_hsa043500.46071629
128Carbon metabolism_Homo sapiens_hsa012000.45550301
129FoxO signaling pathway_Homo sapiens_hsa040680.45441400
130Prolactin signaling pathway_Homo sapiens_hsa049170.44837529
131Shigellosis_Homo sapiens_hsa051310.44431698
132Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43672655
133Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.43224838
134Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.42521092
135Pancreatic cancer_Homo sapiens_hsa052120.41463899
136TNF signaling pathway_Homo sapiens_hsa046680.41192130
137Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39793118
138HIF-1 signaling pathway_Homo sapiens_hsa040660.39512261
139Adipocytokine signaling pathway_Homo sapiens_hsa049200.39416783
140Prostate cancer_Homo sapiens_hsa052150.39097988
141Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38415949
142NOD-like receptor signaling pathway_Homo sapiens_hsa046210.37725758
143Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36927443
144Amoebiasis_Homo sapiens_hsa051460.36764184
145Salivary secretion_Homo sapiens_hsa049700.36685887
146Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34479055
147Proteoglycans in cancer_Homo sapiens_hsa052050.34349162
148Type II diabetes mellitus_Homo sapiens_hsa049300.33592672
149Long-term depression_Homo sapiens_hsa047300.32575044
150Inositol phosphate metabolism_Homo sapiens_hsa005620.31877525
151PI3K-Akt signaling pathway_Homo sapiens_hsa041510.31598162
152Pyrimidine metabolism_Homo sapiens_hsa002400.31491847
153mRNA surveillance pathway_Homo sapiens_hsa030150.31067979
154Phototransduction_Homo sapiens_hsa047440.30231003

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