EDEM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: In the endoplasmic reticulum (ER), misfolded proteins are retrotranslocated to the cytosol and degraded by the proteasome in a process known as ER-associated degradation (ERAD). EDEM2 belongs to a family of proteins involved in ERAD of glycoproteins (Mast et al., 2005 [PubMed 15537790]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)7.80934663
2Golgi transport vesicle coating (GO:0048200)7.80934663
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)7.60696798
4protein retention in ER lumen (GO:0006621)7.31147025
5exocrine pancreas development (GO:0031017)7.23869889
6signal peptide processing (GO:0006465)6.88236454
7intestinal cholesterol absorption (GO:0030299)6.12268596
8protein maturation by protein folding (GO:0022417)5.10927527
9ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.78378758
10COPII vesicle coating (GO:0048208)4.74631858
11activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.70553494
12positive regulation of nuclease activity (GO:0032075)4.56615633
13digestion (GO:0007586)4.43577118
14antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.32997183
15antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.32997183
16endoplasmic reticulum unfolded protein response (GO:0030968)4.25276811
17regulation of nuclease activity (GO:0032069)4.22854271
18valine metabolic process (GO:0006573)4.18294045
19retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.17936706
20regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.17401151
21cellular response to unfolded protein (GO:0034620)4.12509949
22cellular response to topologically incorrect protein (GO:0035967)4.02342581
23neutrophil activation involved in immune response (GO:0002283)3.95374706
24response to peptidoglycan (GO:0032494)3.93285482
25GDP-mannose metabolic process (GO:0019673)3.92860124
26ER-nucleus signaling pathway (GO:0006984)3.91164388
27* protein N-linked glycosylation via asparagine (GO:0018279)3.90068518
28* peptidyl-asparagine modification (GO:0018196)3.85230440
29proline biosynthetic process (GO:0006561)3.82052436
30antigen processing and presentation of endogenous antigen (GO:0019883)3.72566212
31response to endoplasmic reticulum stress (GO:0034976)3.72377591
32mitochondrial calcium ion transport (GO:0006851)3.71244425
33immunoglobulin mediated immune response (GO:0016064)3.66060200
34erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.64008075
35L-phenylalanine catabolic process (GO:0006559)3.64008075
36endocrine pancreas development (GO:0031018)3.63517352
37UDP-N-acetylglucosamine metabolic process (GO:0006047)3.62793449
38* protein N-linked glycosylation (GO:0006487)3.58921107
39sequestering of metal ion (GO:0051238)3.57818528
40negative regulation of interleukin-12 production (GO:0032695)3.51524069
41regulation of podosome assembly (GO:0071801)3.48159822
42L-phenylalanine metabolic process (GO:0006558)3.45149679
43erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.45149679
44positive regulation of gamma-delta T cell activation (GO:0046645)3.40617912
45antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.39446513
46intestinal absorption (GO:0050892)3.38863983
47transcytosis (GO:0045056)3.36722597
48positive regulation by symbiont of host defense response (GO:0052509)3.34191024
49modulation by symbiont of host defense response (GO:0052031)3.34191024
50modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.34191024
51modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.34191024
52positive regulation by organism of defense response of other organism involved in symbiotic interact3.34191024
53modulation by symbiont of host immune response (GO:0052553)3.34191024
54detection of other organism (GO:0098543)3.33208691
554-hydroxyproline metabolic process (GO:0019471)3.31539492
56pinocytosis (GO:0006907)3.29066986
57cysteine metabolic process (GO:0006534)3.25763824
58glycosphingolipid catabolic process (GO:0046479)3.22837872
59detection of bacterium (GO:0016045)3.19548304
60cell redox homeostasis (GO:0045454)3.18115764
61antigen processing and presentation via MHC class Ib (GO:0002475)3.16740209
62sulfur amino acid catabolic process (GO:0000098)3.15388715
63peptide catabolic process (GO:0043171)3.12516712
64glycolipid catabolic process (GO:0019377)3.09982438
65myeloid dendritic cell differentiation (GO:0043011)3.01323546
66amyloid precursor protein catabolic process (GO:0042987)3.00463515
67detection of external biotic stimulus (GO:0098581)3.00059806
68B cell mediated immunity (GO:0019724)2.99445184
69* response to unfolded protein (GO:0006986)2.98356141
70detection of molecule of bacterial origin (GO:0032490)2.96455206
71vesicle coating (GO:0006901)2.95371191
72* response to topologically incorrect protein (GO:0035966)2.94169997
73disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.93219363
74killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.93219363
75L-alpha-amino acid transmembrane transport (GO:1902475)2.91901274
76branched-chain amino acid metabolic process (GO:0009081)2.89929439
77SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.89773522
78myeloid dendritic cell activation (GO:0001773)2.89384996
79negative regulation of digestive system process (GO:0060457)2.88952114
80branched-chain amino acid catabolic process (GO:0009083)2.88364591
81negative regulation of cell killing (GO:0031342)2.86804841
82negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.86804841
83proline metabolic process (GO:0006560)2.86171803
84regulation of superoxide anion generation (GO:0032928)2.85370153
85pteridine-containing compound biosynthetic process (GO:0042559)2.85132411
86protein targeting to ER (GO:0045047)2.83770308
87serine family amino acid biosynthetic process (GO:0009070)2.83701374
88peptide hormone processing (GO:0016486)2.83436244
89lipopolysaccharide-mediated signaling pathway (GO:0031663)2.83269658
90cotranslational protein targeting to membrane (GO:0006613)2.83028501
91ER to Golgi vesicle-mediated transport (GO:0006888)2.82332191
92neutrophil mediated immunity (GO:0002446)2.81366292
93cholesterol catabolic process (GO:0006707)2.81066917
94sterol catabolic process (GO:0016127)2.81066917
95ER overload response (GO:0006983)2.80319881
96cellular extravasation (GO:0045123)2.79124431
97maintenance of protein localization in organelle (GO:0072595)2.79034108
98negative regulation of myeloid cell apoptotic process (GO:0033033)2.78923303
99protein autoprocessing (GO:0016540)2.77345175
100nucleotide-sugar metabolic process (GO:0009225)2.76151205
101glandular epithelial cell differentiation (GO:0002067)2.73493929
102protein localization to endoplasmic reticulum (GO:0070972)2.73353808
103oligosaccharide catabolic process (GO:0009313)2.71958979
104macrophage activation involved in immune response (GO:0002281)2.71761241
105type I interferon signaling pathway (GO:0060337)2.71738018
106cellular response to type I interferon (GO:0071357)2.71738018
107establishment of protein localization to endoplasmic reticulum (GO:0072599)2.70675317
108antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.68681194
109amino sugar catabolic process (GO:0046348)2.67423921
110cobalamin metabolic process (GO:0009235)2.67015485
111response to type I interferon (GO:0034340)2.64777367
112ceramide catabolic process (GO:0046514)2.64349893
113macrophage activation (GO:0042116)2.62359304
114cellular modified amino acid catabolic process (GO:0042219)2.61686701
115positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.61464693
116L-serine metabolic process (GO:0006563)2.61393580
117regulation of vitamin D biosynthetic process (GO:0060556)2.61074699
118granulocyte activation (GO:0036230)2.60963822
119positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.60197054
120negative regulation of cytokine production involved in immune response (GO:0002719)2.60176517
121interferon-gamma-mediated signaling pathway (GO:0060333)2.59600859
122positive regulation of monocyte chemotaxis (GO:0090026)2.59360658
123regulation of mast cell degranulation (GO:0043304)2.59062641
124regulation of interferon-beta biosynthetic process (GO:0045357)2.58279710
125fucose metabolic process (GO:0006004)2.56948022
126complement activation, classical pathway (GO:0006958)2.56793768
127antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.55897005
128neutrophil activation (GO:0042119)2.55757697
129positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.55368515
130leukocyte aggregation (GO:0070486)2.54840028
131detection of biotic stimulus (GO:0009595)2.54675447
132regulation of T cell tolerance induction (GO:0002664)2.52604386
133positive regulation of isotype switching (GO:0045830)2.52422749
134membrane lipid catabolic process (GO:0046466)2.51481999
135regulation of myeloid leukocyte mediated immunity (GO:0002886)2.49895862
136DNA deamination (GO:0045006)2.49835322
137positive regulation of chemokine biosynthetic process (GO:0045080)2.49651033
138negative regulation of interleukin-17 production (GO:0032700)2.48502874
139aromatic amino acid family catabolic process (GO:0009074)2.48450602
140regulation of cholesterol esterification (GO:0010872)2.47179364
141nucleoside diphosphate catabolic process (GO:0009134)2.47083259
142negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.46844808
143pentose-phosphate shunt (GO:0006098)2.46002242
144regulation of vitamin metabolic process (GO:0030656)2.45923479
145nucleotide-sugar biosynthetic process (GO:0009226)2.45625810
146positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.45106070
147zinc ion transport (GO:0006829)2.44524207
148beta-amyloid metabolic process (GO:0050435)2.44213912
149defense response to protozoan (GO:0042832)2.44053550
150positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.43661277
151regulation of chemokine biosynthetic process (GO:0045073)2.43067559
152production of molecular mediator involved in inflammatory response (GO:0002532)2.42555677
153regulation of response to interferon-gamma (GO:0060330)2.41702099
154negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.40979999
155endosome to melanosome transport (GO:0035646)2.40462042
156endosome to pigment granule transport (GO:0043485)2.40462042
157regulation of leukocyte degranulation (GO:0043300)2.39975448
158regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.38749074
159tricarboxylic acid metabolic process (GO:0072350)2.38672255
160Arp2/3 complex-mediated actin nucleation (GO:0034314)2.38017857
161respiratory burst (GO:0045730)2.37953602
162negative regulation of glycoprotein biosynthetic process (GO:0010561)2.37680255
163regulation of B cell receptor signaling pathway (GO:0050855)2.37333236
164myeloid cell activation involved in immune response (GO:0002275)2.37186738
165regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.36622754
166regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.36200359
167NADPH regeneration (GO:0006740)2.35590992
168peptide metabolic process (GO:0006518)2.35432146
169regulation of tolerance induction (GO:0002643)2.35102285
170dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.35029256
171NIK/NF-kappaB signaling (GO:0038061)2.34983866
172positive regulation of B cell differentiation (GO:0045579)2.34727577
173mature B cell differentiation involved in immune response (GO:0002313)2.34584738
174antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.34317169
175folic acid-containing compound biosynthetic process (GO:0009396)2.33884751
176regulation of type B pancreatic cell apoptotic process (GO:2000674)2.33441538
177positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.33349638
178regulation of gamma-delta T cell activation (GO:0046643)2.32892057
179lipopolysaccharide biosynthetic process (GO:0009103)2.32847957
180misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.32788320
181regulation of cytokine secretion involved in immune response (GO:0002739)2.32782846
182regulation of dendritic cell antigen processing and presentation (GO:0002604)2.32065332
183dendritic cell differentiation (GO:0097028)2.31552244
184regulation of mast cell activation involved in immune response (GO:0033006)2.31210953
185positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.30964040
186regulation of interleukin-17 production (GO:0032660)2.28517947
187negative regulation of innate immune response (GO:0045824)2.28479266
188regulation of antigen processing and presentation (GO:0002577)2.28234607
189positive regulation of B cell mediated immunity (GO:0002714)2.28123108
190positive regulation of immunoglobulin mediated immune response (GO:0002891)2.28123108

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human3.98921584
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.86172328
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.79653026
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.01835944
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.97282778
6RXR_22158963_ChIP-Seq_LIVER_Mouse2.70198488
7PPARA_22158963_ChIP-Seq_LIVER_Mouse2.60672597
8* CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.56620858
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.53274351
10GATA1_22025678_ChIP-Seq_K562_Human2.46303893
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.32512153
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.29408855
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.29239671
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.25729112
15SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.22589816
16* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.14197110
17IRF8_21731497_ChIP-ChIP_J774_Mouse2.14048903
18PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.13049760
19* CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.12736570
20RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.12262447
21FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.05966556
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.05765745
23FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.98767783
24KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.96200575
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.95246024
26LXR_22158963_ChIP-Seq_LIVER_Mouse1.92800230
27STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.87601427
28EGR1_23403033_ChIP-Seq_LIVER_Mouse1.87149974
29ERG_20887958_ChIP-Seq_HPC-7_Mouse1.86519791
30NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.86299615
31SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.82978500
32SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.81556400
33TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.79114377
34Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.77388701
35SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.74785036
36MYB_21317192_ChIP-Seq_ERMYB_Mouse1.72639325
37FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.67471146
38MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.66422531
39EGR1_19374776_ChIP-ChIP_THP-1_Human1.65285034
40PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.62711284
41SPI1_23547873_ChIP-Seq_NB4_Human1.60970031
42STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.60549586
43NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.59132477
44* ETS1_20019798_ChIP-Seq_JURKAT_Human1.59011911
45SCL_19346495_ChIP-Seq_HPC-7_Human1.57538294
46EST1_17652178_ChIP-ChIP_JURKAT_Human1.56224172
47E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.55414310
48SPI1_23127762_ChIP-Seq_K562_Human1.54935796
49STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.54877758
50RARG_19884340_ChIP-ChIP_MEFs_Mouse1.54761463
51TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.52841426
52GATA1_22383799_ChIP-Seq_G1ME_Mouse1.51368905
53NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.51026582
54MYC_22102868_ChIP-Seq_BL_Human1.50102675
55CREB1_15753290_ChIP-ChIP_HEK293T_Human1.47210848
56ELK3_25401928_ChIP-Seq_HUVEC_Human1.46246715
57SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.43491890
58DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.41120529
59IRF8_27001747_Chip-Seq_BMDM_Mouse1.40736288
60* GABP_19822575_ChIP-Seq_HepG2_Human1.39967517
61VDR_23849224_ChIP-Seq_CD4+_Human1.38119779
62MYC_18555785_ChIP-Seq_MESCs_Mouse1.37871129
63LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.37298226
64BRD4_27068464_Chip-Seq_AML-cells_Mouse1.35350736
65VDR_21846776_ChIP-Seq_THP-1_Human1.35114505
66MYB_26560356_Chip-Seq_TH2_Human1.34084354
67GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.33964079
68MYC_18358816_ChIP-ChIP_MESCs_Mouse1.33927096
69GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.33130077
70TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.31812905
71* SRF_21415370_ChIP-Seq_HL-1_Mouse1.31445266
72FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.29102257
73E2F1_18555785_ChIP-Seq_MESCs_Mouse1.29008603
74HOXB4_20404135_ChIP-ChIP_EML_Mouse1.28949619
75LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.28919940
76DCP1A_22483619_ChIP-Seq_HELA_Human1.28274684
77HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.28273721
78* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.27301460
79TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26976952
80FOXP3_21729870_ChIP-Seq_TREG_Human1.26919400
81ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.26878074
82TFEB_21752829_ChIP-Seq_HELA_Human1.26209161
83RUNX1_22412390_ChIP-Seq_EML_Mouse1.24220818
84* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23817364
85TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23349398
86GATA2_22383799_ChIP-Seq_G1ME_Mouse1.21075238
87CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.18995642
88PU.1_20513432_ChIP-Seq_Bcells_Mouse1.17700412
89MYB_26560356_Chip-Seq_TH1_Human1.17388220
90CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17273415
91VDR_24763502_ChIP-Seq_THP-1_Human1.16749990
92ZFX_18555785_ChIP-Seq_MESCs_Mouse1.15208536
93LXR_22292898_ChIP-Seq_THP-1_Human1.14074823
94PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13072011
95TP63_17297297_ChIP-ChIP_HaCaT_Human1.12130998
96CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12065312
97SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11630397
98STAT4_19710469_ChIP-ChIP_TH1__Mouse1.10369461
99CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08388694
100GATA4_25053715_ChIP-Seq_YYC3_Human1.07451199
101MAF_26560356_Chip-Seq_TH2_Human1.07405694
102SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.06540387
103BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04968869
104* GATA2_21666600_ChIP-Seq_HMVEC_Human1.04816727
105PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03533293
106PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02796975
107CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02571812
108PU_27001747_Chip-Seq_BMDM_Mouse1.02393643
109CIITA_25753668_ChIP-Seq_RAJI_Human1.02359677
110STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.02273020
111* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.01884084
112STAT3_1855785_ChIP-Seq_MESCs_Mouse1.01568865
113CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.01395624
114ELF1_20517297_ChIP-Seq_JURKAT_Human1.00913757
115RUNX_20019798_ChIP-Seq_JUKART_Human1.00814310
116CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.00777816
117MAF_26560356_Chip-Seq_TH1_Human1.00478729
118HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.99947658
119TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.99095359
120PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.98459350
121HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98011196
122UTX_26944678_Chip-Seq_JUKART_Human0.97343798
123THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.97028819
124* GATA3_27048872_Chip-Seq_THYMUS_Human0.95841732
125IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.95704797
126GATA1_19941827_ChIP-Seq_MEL_Mouse0.94388475
127KDM5A_27292631_Chip-Seq_BREAST_Human0.94375453
128FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.93998551
129MYC_19030024_ChIP-ChIP_MESCs_Mouse0.93725071
130XRN2_22483619_ChIP-Seq_HELA_Human0.93266259
131VDR_24787735_ChIP-Seq_THP-1_Human0.92293806

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005365_abnormal_bile_salt4.31122701
2MP0005083_abnormal_biliary_tract4.28515797
3MP0001666_abnormal_nutrient_absorption4.27549917
4MP0005220_abnormal_exocrine_pancreas3.95842134
5MP0002139_abnormal_hepatobiliary_system3.28243781
6MP0003183_abnormal_peptide_metabolism2.79286848
7MP0005058_abnormal_lysosome_morphology2.74583780
8MP0002693_abnormal_pancreas_physiology2.71632364
9MP0005085_abnormal_gallbladder_physiolo2.70801143
10MP0003868_abnormal_feces_composition2.51861382
11MP0004264_abnormal_extraembryonic_tissu2.48402137
12MP0005451_abnormal_body_composition2.25755544
13MP0008260_abnormal_autophagy2.18986686
14MP0001944_abnormal_pancreas_morphology2.13051129
15MP0001835_abnormal_antigen_presentation2.08637176
16MP0009840_abnormal_foam_cell2.07188009
17MP0005084_abnormal_gallbladder_morpholo2.03472202
18MP0003195_calcinosis1.95589273
19MP0001853_heart_inflammation1.89310337
20MP0003172_abnormal_lysosome_physiology1.89135763
21MP0006054_spinal_hemorrhage1.85233332
22MP0005360_urolithiasis1.84706588
23MP0009643_abnormal_urine_homeostasis1.75382494
24MP0003191_abnormal_cellular_cholesterol1.71450065
25MP0003436_decreased_susceptibility_to1.71014195
26MP0003186_abnormal_redox_activity1.70796695
27MP0008875_abnormal_xenobiotic_pharmacok1.69601422
28MP0002877_abnormal_melanocyte_morpholog1.69049323
29MP0003075_altered_response_to1.68745205
30MP0003300_gastrointestinal_ulcer1.67061429
31MP0003806_abnormal_nucleotide_metabolis1.60403987
32MP0000604_amyloidosis1.60003944
33MP0005310_abnormal_salivary_gland1.55435776
34MP0005671_abnormal_response_to1.51426410
35MP0003252_abnormal_bile_duct1.50474221
36MP0009785_altered_susceptibility_to1.50008610
37MP0001845_abnormal_inflammatory_respons1.49579237
38MP0009764_decreased_sensitivity_to1.43947875
39MP0000343_altered_response_to1.43716013
40MP0005025_abnormal_response_to1.43675878
41MP0002419_abnormal_innate_immunity1.43467538
42MP0002138_abnormal_hepatobiliary_system1.43428476
43MP0004043_abnormal_pH_regulation1.43361406
44MP0003724_increased_susceptibility_to1.43026671
45MP0005464_abnormal_platelet_physiology1.41916955
46MP0010329_abnormal_lipoprotein_level1.41277760
47MP0005332_abnormal_amino_acid1.39609702
48MP0002166_altered_tumor_susceptibility1.38919869
49MP0001764_abnormal_homeostasis1.38264389
50MP0001873_stomach_inflammation1.34554847
51MP0000609_abnormal_liver_physiology1.33653292
52MP0009333_abnormal_splenocyte_physiolog1.32879078
53MP0000685_abnormal_immune_system1.32333043
54MP0008469_abnormal_protein_level1.31877270
55MP0005000_abnormal_immune_tolerance1.30810751
56MP0002118_abnormal_lipid_homeostasis1.29253507
57MP0005636_abnormal_mineral_homeostasis1.28849100
58MP0002078_abnormal_glucose_homeostasis1.27939479
59MP0000490_abnormal_crypts_of1.27770671
60MP0009278_abnormal_bone_marrow1.25698174
61MP0002998_abnormal_bone_remodeling1.25531851
62MP0000613_abnormal_salivary_gland1.25185044
63MP0010155_abnormal_intestine_physiology1.24582679
64MP0003448_altered_tumor_morphology1.24477651
65MP0005379_endocrine/exocrine_gland_phen1.22460207
66MP0002148_abnormal_hypersensitivity_rea1.21666277
67MP0002723_abnormal_immune_serum1.21501694
68MP0005408_hypopigmentation1.20138292
69MP0005397_hematopoietic_system_phenotyp1.19127271
70MP0001545_abnormal_hematopoietic_system1.19127271
71MP0003866_abnormal_defecation1.19078927
72MP0001800_abnormal_humoral_immune1.18554661
73MP0003656_abnormal_erythrocyte_physiolo1.16856649
74MP0003693_abnormal_embryo_hatching1.13679414
75MP0006082_CNS_inflammation1.13123583
76MP0002420_abnormal_adaptive_immunity1.12897595
77MP0002452_abnormal_antigen_presenting1.12690060
78MP0005319_abnormal_enzyme/_coenzyme1.10886105
79MP0001819_abnormal_immune_cell1.10165246
80MP0005166_decreased_susceptibility_to1.09045388
81MP0003959_abnormal_lean_body1.08790743
82MP0002722_abnormal_immune_system1.08610488
83MP0005164_abnormal_response_to1.05811582
84MP0003763_abnormal_thymus_physiology1.05793396
85MP0001790_abnormal_immune_system1.05186111
86MP0005387_immune_system_phenotype1.05186111
87MP0008438_abnormal_cutaneous_collagen1.04182999
88MP0001664_abnormal_digestion1.03071171
89MP0002132_abnormal_respiratory_system1.02405672
90MP0001765_abnormal_ion_homeostasis0.99569385
91MP0003566_abnormal_cell_adhesion0.99279629
92MP0000598_abnormal_liver_morphology0.99272459
93MP0001756_abnormal_urination0.99112996
94MP0000465_gastrointestinal_hemorrhage0.99058580
95MP0003828_pulmonary_edema0.98877747
96MP0002928_abnormal_bile_duct0.97090405
97MP0005165_increased_susceptibility_to0.94056639
98MP0002405_respiratory_system_inflammati0.93154316
99MP0004947_skin_inflammation0.91938970
100MP0003303_peritoneal_inflammation0.91927823
101MP0005023_abnormal_wound_healing0.91304189
102MP0001533_abnormal_skeleton_physiology0.91082361
103MP0010386_abnormal_urinary_bladder0.90368280
104MP0002909_abnormal_adrenal_gland0.89505210
105MP0006036_abnormal_mitochondrial_physio0.89040442
106MP0002933_joint_inflammation0.88718778
107MP0009642_abnormal_blood_homeostasis0.88547493
108MP0000716_abnormal_immune_system0.87676219
109MP0009765_abnormal_xenobiotic_induced0.87605014
110MP0002006_tumorigenesis0.86283680
111MP0003638_abnormal_response/metabolism_0.85242241
112MP0004883_abnormal_blood_vessel0.83388335
113MP0008004_abnormal_stomach_pH0.83346318
114MP0002396_abnormal_hematopoietic_system0.83178565
115MP0001851_eye_inflammation0.82586012
116MP0002398_abnormal_bone_marrow0.82046974
117MP0000689_abnormal_spleen_morphology0.82021669
118MP0005390_skeleton_phenotype0.81654146
119MP0005584_abnormal_enzyme/coenzyme_acti0.81221738
120MP0003690_abnormal_glial_cell0.81068883
121MP0001958_emphysema0.80845680
122MP0009763_increased_sensitivity_to0.80677585
123MP0000858_altered_metastatic_potential0.80345639
124MP0002429_abnormal_blood_cell0.79858629
125MP0000681_abnormal_thyroid_gland0.79564075
126MP0001915_intracranial_hemorrhage0.79523772
127MP0000678_abnormal_parathyroid_gland0.78971768
128MP0004782_abnormal_surfactant_physiolog0.78503079
129MP0000013_abnormal_adipose_tissue0.78334372
130MP0003795_abnormal_bone_structure0.77755845
131MP0005167_abnormal_blood-brain_barrier0.73944488
132MP0003091_abnormal_cell_migration0.72332411
133MP0002254_reproductive_system_inflammat0.71819658
134MP0000249_abnormal_blood_vessel0.70621372
135MP0003453_abnormal_keratinocyte_physiol0.70142546

Predicted human phenotypes

RankGene SetZ-score
1Vacuolated lymphocytes (HP:0001922)4.53884906
2Abnormality of aromatic amino acid family metabolism (HP:0004338)4.39964293
3Hypoglycemic coma (HP:0001325)4.18262693
4Abnormality of the intrinsic pathway (HP:0010989)3.94972705
5Dysostosis multiplex (HP:0000943)3.92538075
6Hypoglycemic seizures (HP:0002173)3.75150702
7Abnormal protein glycosylation (HP:0012346)3.60360653
8Abnormal glycosylation (HP:0012345)3.60360653
9Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.60360653
10Abnormal protein N-linked glycosylation (HP:0012347)3.60360653
11Reduced antithrombin III activity (HP:0001976)3.55568261
12Mucopolysacchariduria (HP:0008155)3.52623596
13Urinary glycosaminoglycan excretion (HP:0003541)3.52623596
14Hyperinsulinemic hypoglycemia (HP:0000825)3.45028314
15Myositis (HP:0100614)3.38289985
16Type I transferrin isoform profile (HP:0003642)3.33030258
17Fat malabsorption (HP:0002630)3.31762796
18Steatorrhea (HP:0002570)3.31475446
19Loss of speech (HP:0002371)3.29364189
20Generalized aminoaciduria (HP:0002909)3.29000983
21Abnormality of mucopolysaccharide metabolism (HP:0011020)3.25917609
22Abnormality of polysaccharide metabolism (HP:0011012)3.25917609
23Abnormality of glycosaminoglycan metabolism (HP:0004371)3.25917609
24Abnormality of the common coagulation pathway (HP:0010990)3.22520573
25Symptomatic seizures (HP:0011145)3.11909986
26Stomatitis (HP:0010280)3.07848727
27Orchitis (HP:0100796)3.06972440
28Conjugated hyperbilirubinemia (HP:0002908)3.04375494
29Thrombocytosis (HP:0001894)3.00791160
30Abnormality of endocrine pancreas physiology (HP:0012093)2.93125395
31Abnormality of the pancreatic islet cells (HP:0006476)2.93125395
32Hepatosplenomegaly (HP:0001433)2.85778431
33Ketosis (HP:0001946)2.84740671
34Ketoacidosis (HP:0001993)2.84723332
35Mediastinal lymphadenopathy (HP:0100721)2.83234697
36Abnormality of glycolipid metabolism (HP:0010969)2.81837313
37Abnormality of liposaccharide metabolism (HP:0010968)2.81837313
38Abnormality of glycosphingolipid metabolism (HP:0004343)2.81837313
39Late onset (HP:0003584)2.78837670
40Vertebral compression fractures (HP:0002953)2.76518447
41Gout (HP:0001997)2.76044027
42Progressive neurologic deterioration (HP:0002344)2.73382424
43Obstructive lung disease (HP:0006536)2.73330413
44Chronic obstructive pulmonary disease (HP:0006510)2.73330413
45Purpura (HP:0000979)2.70976979
46Deep venous thrombosis (HP:0002625)2.66916049
47Amyloidosis (HP:0011034)2.66196161
48Intrahepatic cholestasis (HP:0001406)2.65520730
49Increased neuronal autofluorescent lipopigment (HP:0002074)2.62735818
50Optic neuritis (HP:0100653)2.59838864
51Retrobulbar optic neuritis (HP:0100654)2.59838864
52Increased serum ferritin (HP:0003281)2.59747300
53Recurrent skin infections (HP:0001581)2.57189783
54Myocardial infarction (HP:0001658)2.55163386
55Increased IgM level (HP:0003496)2.54740751
56Abnormality of monocarboxylic acid metabolism (HP:0010996)2.53656272
57Increased cerebral lipofuscin (HP:0011813)2.52370719
58Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.50470695
59Glomerulonephritis (HP:0000099)2.48092323
60Recurrent fungal infections (HP:0002841)2.46947776
61Abnormality of T cell physiology (HP:0011840)2.46448063
62Recurrent bacterial skin infections (HP:0005406)2.45123404
63Pancreatitis (HP:0001733)2.43931799
64IgM deficiency (HP:0002850)2.43067714
65Autoimmune thrombocytopenia (HP:0001973)2.41282524
66Elevated erythrocyte sedimentation rate (HP:0003565)2.40812436
67Exocrine pancreatic insufficiency (HP:0001738)2.38513330
68Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.37433358
69Gingival bleeding (HP:0000225)2.34281840
70Abnormality of fatty-acid metabolism (HP:0004359)2.34218041
71Recurrent abscess formation (HP:0002722)2.32360474
72Abnormality of complement system (HP:0005339)2.27725326
73Meningitis (HP:0001287)2.25037169
74Recurrent gram-negative bacterial infections (HP:0005420)2.24876184
75Urticaria (HP:0001025)2.23694176
76Beaking of vertebral bodies (HP:0004568)2.23457046
77Gingivitis (HP:0000230)2.22016697
78Epistaxis (HP:0000421)2.21597143
79Thoracic kyphosis (HP:0002942)2.19565284
80Aplastic anemia (HP:0001915)2.18117972
81Prolonged partial thromboplastin time (HP:0003645)2.14497836
82Abnormality of subcutaneous fat tissue (HP:0001001)2.14382486
83Limb hypertonia (HP:0002509)2.13829202
84Type I diabetes mellitus (HP:0100651)2.12528268
85Interstitial pulmonary disease (HP:0006530)2.11374882
86Abnormality of iron homeostasis (HP:0011031)2.11073691
87Retinal atrophy (HP:0001105)2.10631210
88Abnormality of the vasculature of the conjunctiva (HP:0008054)2.10411272
89Prolonged neonatal jaundice (HP:0006579)2.09987924
90Large for gestational age (HP:0001520)2.07113866
91Pancreatic islet-cell hyperplasia (HP:0004510)2.06145549
92Gastrointestinal infarctions (HP:0005244)2.05891878
93Abnormality of macrophages (HP:0004311)2.04752004
94Hypergammaglobulinemia (HP:0010702)2.04377259
95Pulmonary infiltrates (HP:0002113)2.04062644
96Hyperbilirubinemia (HP:0002904)2.03704709
97Abnormal pancreas size (HP:0012094)2.03221625
98Vasculitis (HP:0002633)2.02421106
99Upper motor neuron abnormality (HP:0002127)2.00355687
100Fatigue (HP:0012378)2.00032753
101Episodic fever (HP:0001954)1.99635689
102Autoimmune hemolytic anemia (HP:0001890)1.97845154
103Cellulitis (HP:0100658)1.97295314
104Petechiae (HP:0000967)1.96950013
105Abnormal gallbladder physiology (HP:0012438)1.96692249
106Cholecystitis (HP:0001082)1.96692249
107Hypoplasia of the pons (HP:0012110)1.96322559
108Gastrointestinal inflammation (HP:0004386)1.95315465
109Pustule (HP:0200039)1.95237459
110Eczematoid dermatitis (HP:0000976)1.95062214
111Joint stiffness (HP:0001387)1.94673208
112Anorexia (HP:0002039)1.92743320
113Xanthomatosis (HP:0000991)1.92698945
114Systemic lupus erythematosus (HP:0002725)1.91695719
115Dicarboxylic aciduria (HP:0003215)1.91661377
116Abnormality of dicarboxylic acid metabolism (HP:0010995)1.91661377
117Abnormality of sulfur amino acid metabolism (HP:0004339)1.90515207
118Disinhibition (HP:0000734)1.90439303
119Chronic otitis media (HP:0000389)1.90394268
120T lymphocytopenia (HP:0005403)1.89543583
121Abnormality of the pons (HP:0007361)1.89490201
122Encephalitis (HP:0002383)1.89281800
123Inflammation of the large intestine (HP:0002037)1.87257411
124Spontaneous hematomas (HP:0007420)1.86939610
125Abdominal distention (HP:0003270)1.85833489
126Abnormal delayed hypersensitivity skin test (HP:0002963)1.85611526
127Abnormality of purine metabolism (HP:0004352)1.85553406
128Hyperglycemia (HP:0003074)1.85470307
129Glomerulopathy (HP:0100820)1.82793802
130Chronic mucocutaneous candidiasis (HP:0002728)1.82758300
131Recurrent cutaneous fungal infections (HP:0011370)1.82758300
132Recurrent viral infections (HP:0004429)1.82516110
133Mucosal telangiectasiae (HP:0100579)1.82355533
134Prolonged bleeding time (HP:0003010)1.82254001
135Recurrent bronchitis (HP:0002837)1.82229024
136Abnormality of transition element cation homeostasis (HP:0011030)1.81465144
137Osteomyelitis (HP:0002754)1.81453854
138Progressive muscle weakness (HP:0003323)1.81439568
139Joint swelling (HP:0001386)1.81178988
140Abnormality of T cell number (HP:0011839)1.80661844
141Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.80607817
142Joint hemorrhage (HP:0005261)1.79392114
143Decreased subcutaneous fat (HP:0001002)1.79383904
144Nonimmune hydrops fetalis (HP:0001790)1.77962346
145Increased IgE level (HP:0003212)1.77749214
146Periodontitis (HP:0000704)1.77250196
147Colitis (HP:0002583)1.76807777
148Opisthotonus (HP:0002179)1.76211634
149Acute hepatic failure (HP:0006554)1.75497870
150Insulin-resistant diabetes mellitus (HP:0000831)1.75119086
151Keratoconjunctivitis sicca (HP:0001097)1.75063131
152Pulmonary embolism (HP:0002204)1.73909449
153Complement deficiency (HP:0004431)1.73468853
154Lower limb hyperreflexia (HP:0002395)1.73331714
155Arterial thrombosis (HP:0004420)1.73159022
156Polyneuropathy (HP:0001271)1.73104686
157Malnutrition (HP:0004395)1.72143415
158Hemoptysis (HP:0002105)1.71594626
159Splenomegaly (HP:0001744)1.70600817
160Impaired platelet aggregation (HP:0003540)1.70236343
161Abnormal platelet function (HP:0011869)1.70236343
162Hypoplasia of the thymus (HP:0000778)1.70072360
163Hemorrhage of the eye (HP:0011885)1.70050364
164Hyperammonemia (HP:0001987)1.69904473
165Cardiomegaly (HP:0001640)1.69880796
166Hematochezia (HP:0002573)1.69396256
167Increased CSF protein (HP:0002922)1.68447658
168Granulocytopenia (HP:0001913)1.68430288

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.62277162
2BCKDK4.82580403
3TAOK33.99507134
4EIF2AK33.21428926
5INSRR3.00792982
6PASK2.91923950
7MAPK152.67656218
8RIPK42.56434779
9FLT32.50833414
10IRAK32.47635995
11SCYL22.44988238
12STK162.32044631
13IRAK42.27538761
14NME22.16774638
15MAP4K11.95378424
16TYK21.93972453
17TBK11.92824903
18ZAP701.90898270
19PRPF4B1.81625915
20MAP2K21.72075064
21MAPKAPK31.56043235
22JAK31.53226665
23TAOK21.46135268
24KIT1.41556465
25IKBKE1.38161142
26HIPK21.38123209
27BTK1.37922597
28FGR1.36037846
29SIK31.32874483
30EEF2K1.26611595
31BRSK21.23248252
32TEC1.22251144
33PIK3CG1.21864475
34ARAF1.20894410
35FGFR41.12019255
36TRIB31.11801862
37SIK11.08686292
38MAP3K121.07348078
39EPHA31.07150636
40HCK1.06884575
41PDK21.05506182
42PKN21.05414849
43BMPR21.03568085
44ACVR1B1.03335427
45GRK71.00606182
46TNK21.00210962
47BLK0.97794110
48CSF1R0.97305374
49EPHB10.95914337
50KDR0.92709094
51IRAK10.92096569
52MAP3K130.90667224
53MAP3K140.85967187
54CAMKK20.85260248
55PTK60.83621476
56RPS6KB20.82999483
57MAP2K30.82843530
58MAP3K10.81344564
59SYK0.80084703
60FRK0.77188860
61MOS0.75845467
62JAK20.75755546
63TGFBR20.75309653
64JAK10.74901874
65ITK0.73587946
66IRAK20.73354872
67LIMK10.71876250
68MAP3K20.71870885
69MARK30.71042280
70MST40.71040669
71TAOK10.69551807
72PIM20.69264243
73TESK20.69081963
74EPHA20.68828978
75LATS10.68255550
76VRK20.67646483
77LRRK20.66577922
78LYN0.66410696
79IKBKB0.64147817
80NEK90.62214180
81EIF2AK10.59909191
82MAP3K30.59330863
83ADRBK20.58907751
84CSK0.58213752
85PDPK10.57707809
86PBK0.57444792
87PRKG20.56054906
88NUAK10.55874622
89RIPK10.55190193
90TIE10.55012637
91RPS6KA40.54615981
92MAP3K50.54045477
93MST1R0.53572377
94NLK0.53001500
95WNK40.51527756
96FGFR30.50795943
97MATK0.50263091
98PDK10.49659784
99SMG10.49155142
100MAPK110.49105854
101CDK60.48948303
102LCK0.48819819
103MAPKAPK50.46003432
104STK100.45761360
105KSR20.45499924
106TXK0.43034631
107ILK0.43008727
108DDR20.42606145
109CDC42BPA0.42001177
110LMTK20.41713791
111CHUK0.41691536
112PAK10.40999002
113VRK10.40995492
114GRK60.39651598
115MYLK0.39649781
116DYRK1B0.39563050
117ABL10.37000775
118MAP3K110.36114244
119PAK40.35941237
120MAP3K80.35371975
121ABL20.35195648
122FES0.34374679
123MAPKAPK20.32414612
124DYRK30.32254016
125CDK80.30936760
126PIM10.29558791
127BMPR1B0.28840093
128CDK190.28159762
129PAK20.27524348
130MAP2K60.25348847
131PTK20.24937314
132PRKCD0.24834933
133TGFBR10.23795828
134MAPK30.22931553
135TESK10.21932877
136RPS6KA60.21819499
137PRKCI0.20236590
138BRAF0.19230380

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030605.70815995
2Maturity onset diabetes of the young_Homo sapiens_hsa049505.21816924
3* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.24646878
4Folate biosynthesis_Homo sapiens_hsa007902.92331212
5Other glycan degradation_Homo sapiens_hsa005112.63159261
6Pancreatic secretion_Homo sapiens_hsa049722.59291435
7Fat digestion and absorption_Homo sapiens_hsa049752.47484640
8Sulfur metabolism_Homo sapiens_hsa009202.46625263
9Allograft rejection_Homo sapiens_hsa053302.38448271
10N-Glycan biosynthesis_Homo sapiens_hsa005102.35095716
11Graft-versus-host disease_Homo sapiens_hsa053322.26513774
12Rheumatoid arthritis_Homo sapiens_hsa053232.21452539
13Osteoclast differentiation_Homo sapiens_hsa043802.05386956
14Autoimmune thyroid disease_Homo sapiens_hsa053201.96615000
15Selenocompound metabolism_Homo sapiens_hsa004501.94775833
16Lysosome_Homo sapiens_hsa041421.81180524
17Glycosaminoglycan degradation_Homo sapiens_hsa005311.78794377
18Malaria_Homo sapiens_hsa051441.76829774
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.76755737
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.71842102
21Tuberculosis_Homo sapiens_hsa051521.70133670
22Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.67035272
23Asthma_Homo sapiens_hsa053101.66587735
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.61342781
25Hematopoietic cell lineage_Homo sapiens_hsa046401.60186108
26Primary bile acid biosynthesis_Homo sapiens_hsa001201.55901013
27Protein digestion and absorption_Homo sapiens_hsa049741.51241474
28Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.50944449
29Sulfur relay system_Homo sapiens_hsa041221.48164155
30Phagosome_Homo sapiens_hsa041451.45646835
31Salmonella infection_Homo sapiens_hsa051321.39043998
32Histidine metabolism_Homo sapiens_hsa003401.37889600
33Tryptophan metabolism_Homo sapiens_hsa003801.34180604
34Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.26441061
35Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.25099780
36Pentose and glucuronate interconversions_Homo sapiens_hsa000401.22686202
37Renin-angiotensin system_Homo sapiens_hsa046141.22297474
38Fatty acid degradation_Homo sapiens_hsa000711.20518759
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.18428041
40Viral myocarditis_Homo sapiens_hsa054161.17194067
41Shigellosis_Homo sapiens_hsa051311.14258452
42Herpes simplex infection_Homo sapiens_hsa051681.14205849
43Antigen processing and presentation_Homo sapiens_hsa046121.13108878
44TNF signaling pathway_Homo sapiens_hsa046681.11605846
45Toxoplasmosis_Homo sapiens_hsa051451.11484351
46Drug metabolism - other enzymes_Homo sapiens_hsa009831.09600957
47Caffeine metabolism_Homo sapiens_hsa002321.09380708
48African trypanosomiasis_Homo sapiens_hsa051431.08178118
49Peroxisome_Homo sapiens_hsa041461.06296647
50NOD-like receptor signaling pathway_Homo sapiens_hsa046211.03104003
51Glycerolipid metabolism_Homo sapiens_hsa005611.01952707
52Legionellosis_Homo sapiens_hsa051341.01616815
53Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.01274334
54Starch and sucrose metabolism_Homo sapiens_hsa005001.00112556
55Vitamin digestion and absorption_Homo sapiens_hsa049770.98645138
56Galactose metabolism_Homo sapiens_hsa000520.96469458
57Vibrio cholerae infection_Homo sapiens_hsa051100.92445478
58Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.91882105
59ABC transporters_Homo sapiens_hsa020100.90470902
60Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.89331809
61Staphylococcus aureus infection_Homo sapiens_hsa051500.88330626
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.87552679
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86994742
64Regulation of autophagy_Homo sapiens_hsa041400.86622271
65Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.85274285
66One carbon pool by folate_Homo sapiens_hsa006700.83832091
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.83532525
68Cyanoamino acid metabolism_Homo sapiens_hsa004600.81675676
69beta-Alanine metabolism_Homo sapiens_hsa004100.81103231
70Complement and coagulation cascades_Homo sapiens_hsa046100.80667552
71T cell receptor signaling pathway_Homo sapiens_hsa046600.79364788
72Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.78616519
73Jak-STAT signaling pathway_Homo sapiens_hsa046300.78491662
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.78155724
75Leukocyte transendothelial migration_Homo sapiens_hsa046700.76358282
76Arginine and proline metabolism_Homo sapiens_hsa003300.75924741
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75711622
78Ribosome_Homo sapiens_hsa030100.74948779
79Apoptosis_Homo sapiens_hsa042100.74440991
80Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.74420274
81Collecting duct acid secretion_Homo sapiens_hsa049660.73813153
82Propanoate metabolism_Homo sapiens_hsa006400.73782186
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.72881734
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.71344725
85Leishmaniasis_Homo sapiens_hsa051400.71265799
86Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70588693
87Acute myeloid leukemia_Homo sapiens_hsa052210.70374531
88Pentose phosphate pathway_Homo sapiens_hsa000300.70262151
89Steroid biosynthesis_Homo sapiens_hsa001000.69786067
90Linoleic acid metabolism_Homo sapiens_hsa005910.68828338
91Amoebiasis_Homo sapiens_hsa051460.68715493
92Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.67489963
93Hepatitis C_Homo sapiens_hsa051600.66949791
94Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66684457
95Cysteine and methionine metabolism_Homo sapiens_hsa002700.65685799
96Chemical carcinogenesis_Homo sapiens_hsa052040.64527723
97Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.64231014
98Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64062296
99PPAR signaling pathway_Homo sapiens_hsa033200.63941374
100Hepatitis B_Homo sapiens_hsa051610.63861649
101Fructose and mannose metabolism_Homo sapiens_hsa000510.63642812
102Chemokine signaling pathway_Homo sapiens_hsa040620.63149349
103Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.62174411
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60727429
105Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.60471533
106Intestinal immune network for IgA production_Homo sapiens_hsa046720.60268482
107Glutathione metabolism_Homo sapiens_hsa004800.59861196
108Epstein-Barr virus infection_Homo sapiens_hsa051690.57499743
109Biosynthesis of amino acids_Homo sapiens_hsa012300.57089238
110Influenza A_Homo sapiens_hsa051640.55717985
111Fatty acid elongation_Homo sapiens_hsa000620.54521830
112RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.54148792
113Proteasome_Homo sapiens_hsa030500.53860431
114Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53707471
115Pyrimidine metabolism_Homo sapiens_hsa002400.53075524
116Metabolic pathways_Homo sapiens_hsa011000.52207142
117HIF-1 signaling pathway_Homo sapiens_hsa040660.46031060
118Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44599583
119Bladder cancer_Homo sapiens_hsa052190.44564086
120Type I diabetes mellitus_Homo sapiens_hsa049400.43707543
121Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.43686159
122Primary immunodeficiency_Homo sapiens_hsa053400.42885892
123Pertussis_Homo sapiens_hsa051330.42849040
124Systemic lupus erythematosus_Homo sapiens_hsa053220.41906601
125NF-kappa B signaling pathway_Homo sapiens_hsa040640.41169710
126Base excision repair_Homo sapiens_hsa034100.40993189
127Toll-like receptor signaling pathway_Homo sapiens_hsa046200.40958888
128Arachidonic acid metabolism_Homo sapiens_hsa005900.40784499
129Endocytosis_Homo sapiens_hsa041440.40086739
130Tyrosine metabolism_Homo sapiens_hsa003500.39455053
131Arginine biosynthesis_Homo sapiens_hsa002200.38967734
132Phenylalanine metabolism_Homo sapiens_hsa003600.38857607
133Pyruvate metabolism_Homo sapiens_hsa006200.38001038
134Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.36912022
135Measles_Homo sapiens_hsa051620.35274622
136Viral carcinogenesis_Homo sapiens_hsa052030.35242351
137Non-homologous end-joining_Homo sapiens_hsa034500.33722027
138Fatty acid metabolism_Homo sapiens_hsa012120.33087205
139Mineral absorption_Homo sapiens_hsa049780.32385388
140DNA replication_Homo sapiens_hsa030300.32233068
141Sphingolipid metabolism_Homo sapiens_hsa006000.27342525
142Carbon metabolism_Homo sapiens_hsa012000.26930203
143B cell receptor signaling pathway_Homo sapiens_hsa046620.24523195
1442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.24034055
145Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.23517638
146Prion diseases_Homo sapiens_hsa050200.23467279

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