EDEM3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Quality control in the endoplasmic reticulum (ER) ensures that only properly folded proteins are retained in the cell through recognition and degradation of misfolded or unassembled proteins. EDEM3 belongs to a group of proteins that accelerate degradation of misfolded glycoproteins in the ER (Hirao et al., 2006 [PubMed 16431915]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)5.25221059
2Golgi transport vesicle coating (GO:0048200)5.25221059
3iron ion import (GO:0097286)4.84246578
4cellular response to ethanol (GO:0071361)4.49703622
5negative regulation of complement activation (GO:0045916)4.00107481
6negative regulation of protein activation cascade (GO:2000258)3.94969452
7nuclear pore complex assembly (GO:0051292)3.79788355
8insulin-like growth factor receptor signaling pathway (GO:0048009)3.77601411
9activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.76900030
10sequestering of extracellular ligand from receptor (GO:0035581)3.70073451
11maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.67101925
12COPII vesicle coating (GO:0048208)3.56981897
13positive regulation of nuclease activity (GO:0032075)3.54642022
14retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.46768672
15cytoplasmic mRNA processing body assembly (GO:0033962)3.36581694
16protein localization to endosome (GO:0036010)3.35829416
17interleukin-6-mediated signaling pathway (GO:0070102)3.35205910
18vesicle coating (GO:0006901)3.33969622
19Golgi to endosome transport (GO:0006895)3.30201033
20phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.29169543
21endoplasmic reticulum unfolded protein response (GO:0030968)3.24788821
22protein retention in ER lumen (GO:0006621)3.19726876
23regulation of nuclease activity (GO:0032069)3.18036321
24nuclear pore organization (GO:0006999)3.17252859
25negative regulation of humoral immune response (GO:0002921)3.16305026
26early endosome to late endosome transport (GO:0045022)3.16081972
27ER-nucleus signaling pathway (GO:0006984)3.12371990
28cellular response to unfolded protein (GO:0034620)3.11739350
29intestinal cholesterol absorption (GO:0030299)3.07474941
30macroautophagy (GO:0016236)3.05599247
31protein targeting to vacuole (GO:0006623)2.98051229
32protein targeting to lysosome (GO:0006622)2.98051229
33establishment of protein localization to vacuole (GO:0072666)2.98051229
34positive regulation of fatty acid beta-oxidation (GO:0032000)2.97251393
35alpha-linolenic acid metabolic process (GO:0036109)2.95317912
36protein targeting to Golgi (GO:0000042)2.92896767
37regulation of fatty acid beta-oxidation (GO:0031998)2.91041186
38exocrine pancreas development (GO:0031017)2.89712224
39cytoskeletal anchoring at plasma membrane (GO:0007016)2.88534336
40regulation of cholesterol homeostasis (GO:2000188)2.88443570
41endoplasmic reticulum organization (GO:0007029)2.85695615
42signal peptide processing (GO:0006465)2.84765807
43cellular response to topologically incorrect protein (GO:0035967)2.83077170
444-hydroxyproline metabolic process (GO:0019471)2.82503200
45positive regulation of macroautophagy (GO:0016239)2.81372206
46import into cell (GO:0098657)2.81146973
47establishment of protein localization to Golgi (GO:0072600)2.80625530
48positive regulation of glycogen biosynthetic process (GO:0045725)2.80330465
49retrograde transport, vesicle recycling within Golgi (GO:0000301)2.73823277
50response to endoplasmic reticulum stress (GO:0034976)2.71019330
51cysteine metabolic process (GO:0006534)2.70885868
52hepatocyte apoptotic process (GO:0097284)2.70005486
53regulation of type B pancreatic cell apoptotic process (GO:2000674)2.66686237
54regulation of complement activation (GO:0030449)2.66351023
55UDP-N-acetylglucosamine metabolic process (GO:0006047)2.65648881
56embryonic retina morphogenesis in camera-type eye (GO:0060059)2.65485449
57regulation of protein activation cascade (GO:2000257)2.64934017
58lysine catabolic process (GO:0006554)2.64606869
59lysine metabolic process (GO:0006553)2.64606869
60positive regulation of protein autophosphorylation (GO:0031954)2.63956552
61positive regulation of glycolytic process (GO:0045821)2.63323680
62growth hormone receptor signaling pathway (GO:0060396)2.60886872
63pore complex assembly (GO:0046931)2.60642506
64Golgi organization (GO:0007030)2.60285716
65detection of molecule of bacterial origin (GO:0032490)2.58103115
66regulation of steroid hormone biosynthetic process (GO:0090030)2.58086654
67regulation of Rac protein signal transduction (GO:0035020)2.57921955
68platelet-derived growth factor receptor signaling pathway (GO:0048008)2.57262032
69regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.56043385
70regulation of fibrinolysis (GO:0051917)2.55229338
71sulfur amino acid catabolic process (GO:0000098)2.54122516
72hormone catabolic process (GO:0042447)2.53259430
73regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.53007956
74L-serine transport (GO:0015825)2.52808108
75cellular glucuronidation (GO:0052695)2.52710395
76intestinal absorption (GO:0050892)2.52150191
77cellular extravasation (GO:0045123)2.50954482
78apoptotic cell clearance (GO:0043277)2.50093603
79cell adhesion mediated by integrin (GO:0033627)2.49770945
80negative regulation of fatty acid transport (GO:2000192)2.48323085
81hypotonic response (GO:0006971)2.47889636
82positive regulation of histone deacetylation (GO:0031065)2.46643134
83ER overload response (GO:0006983)2.45916783
84sequestering of metal ion (GO:0051238)2.45346775
85carnitine shuttle (GO:0006853)2.44785544
86ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.44134640
87negative regulation of neurotransmitter secretion (GO:0046929)2.43770413
88carnitine transport (GO:0015879)2.42869520
89amino-acid betaine transport (GO:0015838)2.42869520
90mRNA modification (GO:0016556)2.41491932
91intracellular lipid transport (GO:0032365)2.41043579
92cellular response to growth hormone stimulus (GO:0071378)2.39998304
93negative regulation of protein localization to plasma membrane (GO:1903077)2.39565537
94regulation of clathrin-mediated endocytosis (GO:2000369)2.38779687
95dicarboxylic acid biosynthetic process (GO:0043650)2.38229724
96negative regulation of hormone metabolic process (GO:0032351)2.37863984
97regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.35611480
98I-kappaB phosphorylation (GO:0007252)2.35497965
99definitive hemopoiesis (GO:0060216)2.35049415
100regulation of glucose import in response to insulin stimulus (GO:2001273)2.33059943
101carnitine transmembrane transport (GO:1902603)2.33042175
102cellular zinc ion homeostasis (GO:0006882)2.32954342
103regulation of glucocorticoid metabolic process (GO:0031943)2.32934053
104positive regulation of glycogen metabolic process (GO:0070875)2.32434613
105L-phenylalanine catabolic process (GO:0006559)2.32387707
106erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.32387707
107protein carboxylation (GO:0018214)2.32020328
108peptidyl-glutamic acid carboxylation (GO:0017187)2.32020328
109cellular modified amino acid catabolic process (GO:0042219)2.31921523
110valine metabolic process (GO:0006573)2.30479550
111hippo signaling (GO:0035329)2.29813345
112regulation of polysaccharide biosynthetic process (GO:0032885)2.28723774
113hemidesmosome assembly (GO:0031581)2.28535695
114* response to unfolded protein (GO:0006986)2.28429022
115chondrocyte development (GO:0002063)2.27288992
116positive regulation of fatty acid oxidation (GO:0046321)2.26479276
117membrane protein ectodomain proteolysis (GO:0006509)2.25234548
118zinc ion transport (GO:0006829)2.25097063
119positive regulation of cellular amide metabolic process (GO:0034250)2.23932567
120negative regulation of fibrinolysis (GO:0051918)2.22756320
121intestinal epithelial cell development (GO:0060576)2.22463597
122positive regulation of p38MAPK cascade (GO:1900745)2.22194988
123pathway-restricted SMAD protein phosphorylation (GO:0060389)2.22037173
124regulation of transforming growth factor beta1 production (GO:0032908)2.21754030
125glucuronate metabolic process (GO:0019585)2.21635649
126uronic acid metabolic process (GO:0006063)2.21635649
127intra-Golgi vesicle-mediated transport (GO:0006891)2.21333437
128L-alpha-amino acid transmembrane transport (GO:1902475)2.20684783
129mannose metabolic process (GO:0006013)2.20680940
130zinc ion transmembrane transport (GO:0071577)2.19974697
131regulation of beta-amyloid formation (GO:1902003)2.19672638
132negative regulation of lipid transport (GO:0032369)2.18312273
133regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.17889377
134receptor catabolic process (GO:0032801)2.17636640
135regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.17091825
136negative regulation of hormone biosynthetic process (GO:0032353)2.15887789
137serine transport (GO:0032329)2.15422248
138Golgi to plasma membrane protein transport (GO:0043001)2.15114552
139positive regulation of muscle hypertrophy (GO:0014742)2.13969044
140positive regulation of cardiac muscle hypertrophy (GO:0010613)2.13969044
141desmosome organization (GO:0002934)2.13901262
142regulation of protein polyubiquitination (GO:1902914)2.13110393
143negative regulation of anoikis (GO:2000811)2.12609342
144phospholipid translocation (GO:0045332)2.12606478
145lipid translocation (GO:0034204)2.12606478
146type B pancreatic cell development (GO:0003323)2.12395934
147* response to topologically incorrect protein (GO:0035966)2.12059154
148phospholipid homeostasis (GO:0055091)2.11852006
149vesicle transport along microtubule (GO:0047496)2.11530811
150negative regulation of cell size (GO:0045792)2.10888546
151smooth muscle tissue development (GO:0048745)2.10837850
152collagen fibril organization (GO:0030199)2.10830044
153positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.10641227
154regulation of membrane lipid distribution (GO:0097035)2.10229024
155epithelial cell differentiation involved in prostate gland development (GO:0060742)2.09832174
156regulation of glucan biosynthetic process (GO:0010962)2.09610768
157regulation of glycogen biosynthetic process (GO:0005979)2.09610768
158N-glycan processing (GO:0006491)2.09385074
159glutamate metabolic process (GO:0006536)2.09299617
160skin morphogenesis (GO:0043589)2.09072383
161complement activation, alternative pathway (GO:0006957)2.08913054
162oligosaccharide catabolic process (GO:0009313)2.07230207
163labyrinthine layer development (GO:0060711)2.06823242
164homocysteine metabolic process (GO:0050667)2.06662933
165auditory receptor cell differentiation (GO:0042491)2.06645950
166low-density lipoprotein particle clearance (GO:0034383)2.05201555
167transcytosis (GO:0045056)2.04715750
168dorsal/ventral axis specification (GO:0009950)2.02648253
169regulation of ARF protein signal transduction (GO:0032012)2.02111871
170drug transmembrane transport (GO:0006855)2.01409927
171regulation of membrane protein ectodomain proteolysis (GO:0051043)2.01237063
172positive regulation of lipid catabolic process (GO:0050996)2.00847677
173positive regulation of hormone biosynthetic process (GO:0046886)2.00673221
174midgut development (GO:0007494)2.00235857

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.63887538
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.36953138
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.25308479
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.83029303
5CLOCK_20551151_ChIP-Seq_293T_Human2.63305623
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.60717920
7RXR_22158963_ChIP-Seq_LIVER_Mouse2.54106587
8LXR_22158963_ChIP-Seq_LIVER_Mouse2.52561232
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.41582358
10* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.14592262
11ZNF217_24962896_ChIP-Seq_MCF-7_Human2.13848624
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.13399420
13STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.09603346
14GATA1_22025678_ChIP-Seq_K562_Human2.02450619
15FOXO3_23340844_ChIP-Seq_DLD1_Human1.90560409
16ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.84800848
17* FOXA2_19822575_ChIP-Seq_HepG2_Human1.80746439
18TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.75297238
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.64226656
20* EZH2_27294783_Chip-Seq_NPCs_Mouse1.63727357
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.63096448
22ESR1_20079471_ChIP-ChIP_T-47D_Human1.61618687
23ZFP57_27257070_Chip-Seq_ESCs_Mouse1.61219900
24* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.60843109
25ESR2_21235772_ChIP-Seq_MCF-7_Human1.60700191
26CDX2_19796622_ChIP-Seq_MESCs_Mouse1.60686951
27SOX2_27498859_Chip-Seq_STOMACH_Mouse1.60633917
28SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.54850618
29* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.52905202
30ESR1_21235772_ChIP-Seq_MCF-7_Human1.52903610
31* NANOG_18555785_Chip-Seq_ESCs_Mouse1.52681600
32TAF15_26573619_Chip-Seq_HEK293_Human1.52370748
33TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.51465942
34PPAR_26484153_Chip-Seq_NCI-H1993_Human1.49114085
35GBX2_23144817_ChIP-Seq_PC3_Human1.47998279
36SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46423360
37* E2F1_18555785_Chip-Seq_ESCs_Mouse1.45788964
38FLI1_27457419_Chip-Seq_LIVER_Mouse1.45628689
39BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.44925332
40AHR_22903824_ChIP-Seq_MCF-7_Human1.43265584
41* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.43214117
42NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.42004234
43* CMYC_18555785_Chip-Seq_ESCs_Mouse1.41692964
44WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.41285927
45* NFE2_27457419_Chip-Seq_LIVER_Mouse1.40550328
46* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.40236720
47SALL1_21062744_ChIP-ChIP_HESCs_Human1.39816655
48SMAD4_21799915_ChIP-Seq_A2780_Human1.38899504
49AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.38514161
50ARNT_22903824_ChIP-Seq_MCF-7_Human1.38147203
51WT1_19549856_ChIP-ChIP_CCG9911_Human1.38019463
52* ER_23166858_ChIP-Seq_MCF-7_Human1.36439593
53MYB_21317192_ChIP-Seq_ERMYB_Mouse1.36266064
54TP53_18474530_ChIP-ChIP_U2OS_Human1.36198740
55NRF2_20460467_ChIP-Seq_MEFs_Mouse1.35829141
56NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.35829141
57MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.35070054
58* P53_22387025_ChIP-Seq_ESCs_Mouse1.33419614
59AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.33188716
60EP300_21415370_ChIP-Seq_HL-1_Mouse1.31751181
61EGR1_19374776_ChIP-ChIP_THP-1_Human1.31359918
62BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.30902272
63DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.30742410
64PCGF2_27294783_Chip-Seq_ESCs_Mouse1.30095963
65SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.29789935
66* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.29374758
67SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.29050005
68SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.29050005
69* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.28924283
70TP53_16413492_ChIP-PET_HCT116_Human1.28693581
71* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.27937108
72CTNNB1_20460455_ChIP-Seq_HCT116_Human1.27759724
73IRF8_27001747_Chip-Seq_BMDM_Mouse1.27497892
74STAT3_23295773_ChIP-Seq_U87_Human1.27466063
75P300_27058665_Chip-Seq_ZR-75-30cells_Human1.27236141
76PIAS1_25552417_ChIP-Seq_VCAP_Human1.24537455
77* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.24431700
78* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.24203210
79* P300_18555785_Chip-Seq_ESCs_Mouse1.24055974
80* CDX2_22108803_ChIP-Seq_LS180_Human1.23964179
81VDR_24787735_ChIP-Seq_THP-1_Human1.22576289
82RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.20977018
83FUS_26573619_Chip-Seq_HEK293_Human1.20822395
84RARG_19884340_ChIP-ChIP_MEFs_Mouse1.20320605
85TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.20041951
86* CRX_20693478_ChIP-Seq_RETINA_Mouse1.19649121
87IRF8_22096565_ChIP-ChIP_GC-B_Human1.19578802
88FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.19161316
89* SOX2_18555785_Chip-Seq_ESCs_Mouse1.18628451
90* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.17869229
91* OCT4_18555785_Chip-Seq_ESCs_Mouse1.17739545
92CJUN_26792858_Chip-Seq_BT549_Human1.17484617
93* STAT3_18555785_Chip-Seq_ESCs_Mouse1.15033827
94RXR_22108803_ChIP-Seq_LS180_Human1.14322836
95ZNF263_19887448_ChIP-Seq_K562_Human1.14240437
96* NMYC_18555785_Chip-Seq_ESCs_Mouse1.13948952
97NFIB_24661679_ChIP-Seq_LUNG_Mouse1.13571001
98AR_21572438_ChIP-Seq_LNCaP_Human1.13271277
99* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.12999193
100SALL4_18804426_ChIP-ChIP_XEN_Mouse1.12762227
101PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.12105890
102SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.11705874
103SOX9_24532713_ChIP-Seq_HFSC_Mouse1.10278176
104* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.10239520
105PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.10085917
106TCF4_18268006_ChIP-ChIP_LS174T_Human1.09824373
107KDM2B_26808549_Chip-Seq_K562_Human1.09303742
108* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.08920186
109SMAD3_21741376_ChIP-Seq_EPCs_Human1.08682237
110NR3C1_23031785_ChIP-Seq_PC12_Mouse1.08606738
111GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.08181950
112WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08172329
113TP63_17297297_ChIP-ChIP_HaCaT_Human1.07482980
114* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.07341252
115FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.06803317
116* GATA6_25053715_ChIP-Seq_YYC3_Human1.06151456
117SOX2_20726797_ChIP-Seq_SW620_Human1.06095971
118PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.05759787
119* BRD4_25478319_ChIP-Seq_HGPS_Human1.05133820
120ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.04846229
121* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.04329952
122P300_19829295_ChIP-Seq_ESCs_Human1.04308169
123FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04206628
124TBX20_22328084_ChIP-Seq_HEART_Mouse1.04205848
125TBX20_22080862_ChIP-Seq_HEART_Mouse1.04205848
126PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04032020
127FOXA1_25552417_ChIP-Seq_VCAP_Human1.03963094
128* PU1_27457419_Chip-Seq_LIVER_Mouse1.03731577
129CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.03293934
130ISL1_27105846_Chip-Seq_CPCs_Mouse1.03208404
131TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01948341
132GATA4_25053715_ChIP-Seq_YYC3_Human1.01780190
133RUNX1_27514584_Chip-Seq_MCF-7_Human1.01238352
134TP63_23658742_ChIP-Seq_EP156T_Human1.00851962
135ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.99661133
136KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.99592713
137TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99206815
138FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.99039417
139EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.98999313
140HIF1A_21447827_ChIP-Seq_MCF-7_Human0.98287390
141SOX2_21211035_ChIP-Seq_LN229_Gbm0.98064936
142DROSHA_22980978_ChIP-Seq_HELA_Human0.98010070
143GATA1_19941826_ChIP-Seq_K562_Human0.97707233
144* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.96466191
145CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.95083973
146EGR1_23403033_ChIP-Seq_LIVER_Mouse0.94235703
147* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.94123041
148* BCAT_22108803_ChIP-Seq_LS180_Human0.94004508
149SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.92339026
150GATA2_21666600_ChIP-Seq_HMVEC_Human0.91428138
151SMAD_19615063_ChIP-ChIP_OVARY_Human0.91290225
152OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90912123
153Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.90851985
154PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.90525769

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.20523779
2MP0003705_abnormal_hypodermis_morpholog3.69217977
3MP0009780_abnormal_chondrocyte_physiolo3.28540261
4MP0008438_abnormal_cutaneous_collagen3.19644532
5MP0002139_abnormal_hepatobiliary_system3.14434034
6MP0005360_urolithiasis3.13963841
7MP0003300_gastrointestinal_ulcer3.12831414
8MP0005365_abnormal_bile_salt2.86734582
9MP0003252_abnormal_bile_duct2.77371833
10MP0001666_abnormal_nutrient_absorption2.55642958
11MP0006054_spinal_hemorrhage2.42809210
12MP0005085_abnormal_gallbladder_physiolo2.21693279
13MP0010352_gastrointestinal_tract_polyps2.20569969
14MP0004264_abnormal_extraembryonic_tissu2.10936374
15MP0002877_abnormal_melanocyte_morpholog2.03128794
16MP0003868_abnormal_feces_composition1.95169400
17MP0008057_abnormal_DNA_replication1.92399555
18MP0002896_abnormal_bone_mineralization1.91738804
19MP0000569_abnormal_digit_pigmentation1.87994377
20MP0005220_abnormal_exocrine_pancreas1.86491733
21MP0002909_abnormal_adrenal_gland1.83113447
22MP0003283_abnormal_digestive_organ1.80411737
23MP0005076_abnormal_cell_differentiation1.80408190
24MP0000013_abnormal_adipose_tissue1.79447358
25MP0005275_abnormal_skin_tensile1.73897061
26MP0003191_abnormal_cellular_cholesterol1.63953902
27MP0002006_tumorigenesis1.63155662
28MP0000537_abnormal_urethra_morphology1.61712574
29MP0009384_cardiac_valve_regurgitation1.60217602
30MP0002396_abnormal_hematopoietic_system1.60062371
31MP0005187_abnormal_penis_morphology1.59021640
32MP0004134_abnormal_chest_morphology1.55799263
33MP0010329_abnormal_lipoprotein_level1.55238086
34MP0004185_abnormal_adipocyte_glucose1.49878246
35MP0003656_abnormal_erythrocyte_physiolo1.49565048
36MP0004272_abnormal_basement_membrane1.49409809
37MP0003566_abnormal_cell_adhesion1.47616804
38MP0003045_fibrosis1.47593359
39MP0001299_abnormal_eye_distance/1.44822130
40MP0000003_abnormal_adipose_tissue1.44497050
41MP0005083_abnormal_biliary_tract1.44218183
42MP0008875_abnormal_xenobiotic_pharmacok1.43107921
43MP0000427_abnormal_hair_cycle1.42353667
44MP0010307_abnormal_tumor_latency1.36481504
45MP0001944_abnormal_pancreas_morphology1.35942353
46MP0005623_abnormal_meninges_morphology1.30844777
47MP0004043_abnormal_pH_regulation1.29360092
48MP0003091_abnormal_cell_migration1.28730237
49MP0010678_abnormal_skin_adnexa1.27540192
50MP0004130_abnormal_muscle_cell1.25755559
51MP0005164_abnormal_response_to1.23755236
52MP0003183_abnormal_peptide_metabolism1.21491171
53MP0009053_abnormal_anal_canal1.18603430
54MP0003172_abnormal_lysosome_physiology1.18314860
55MP0005248_abnormal_Harderian_gland1.18294640
56MP0003828_pulmonary_edema1.18243285
57MP0008961_abnormal_basal_metabolism1.17885249
58MP0004484_altered_response_of1.17127027
59MP0003866_abnormal_defecation1.14528886
60MP0005375_adipose_tissue_phenotype1.12641523
61MP0005503_abnormal_tendon_morphology1.09001297
62MP0003195_calcinosis1.08951881
63MP0000462_abnormal_digestive_system1.07944521
64MP0002166_altered_tumor_susceptibility1.05678421
65MP0000733_abnormal_muscle_development1.05161736
66MP0002928_abnormal_bile_duct1.04796103
67MP0002118_abnormal_lipid_homeostasis1.03830901
68MP0002078_abnormal_glucose_homeostasis1.03334910
69MP0000609_abnormal_liver_physiology1.03332387
70MP0001915_intracranial_hemorrhage1.02127802
71MP0004233_abnormal_muscle_weight1.00487504
72MP0002060_abnormal_skin_morphology1.00278018
73MP0002168_other_aberrant_phenotype0.99698247
74MP0005666_abnormal_adipose_tissue0.98569859
75MP0001958_emphysema0.98156030
76MP0005332_abnormal_amino_acid0.95791499
77MP0009643_abnormal_urine_homeostasis0.95451477
78MP0002693_abnormal_pancreas_physiology0.93303026
79MP0005451_abnormal_body_composition0.92195109
80MP0003724_increased_susceptibility_to0.90449151
81MP0005165_increased_susceptibility_to0.90421899
82MP0008775_abnormal_heart_ventricle0.89912742
83MP0005058_abnormal_lysosome_morphology0.89803262
84MP0004808_abnormal_hematopoietic_stem0.89728771
85MP0002090_abnormal_vision0.89005420
86MP0003303_peritoneal_inflammation0.88576686
87MP0004883_abnormal_blood_vessel0.87405099
88MP0005409_darkened_coat_color0.85963920
89MP0000465_gastrointestinal_hemorrhage0.84447305
90MP0004084_abnormal_cardiac_muscle0.84255709
91MP0002009_preneoplasia0.84151587
92MP0003943_abnormal_hepatobiliary_system0.84025059
93MP0008004_abnormal_stomach_pH0.83895066
94MP0001765_abnormal_ion_homeostasis0.83019081
95MP0004885_abnormal_endolymph0.82758134
96MP0000747_muscle_weakness0.80437600
97MP0001849_ear_inflammation0.79991318
98MP0001881_abnormal_mammary_gland0.75310670
99MP0005310_abnormal_salivary_gland0.75186213
100MP0002115_abnormal_skeleton_extremities0.72616823
101MP0010155_abnormal_intestine_physiology0.72256609
102MP0009703_decreased_birth_body0.72122312
103MP0003890_abnormal_embryonic-extraembry0.71533406
104MP0001661_extended_life_span0.71093888
105MP0002295_abnormal_pulmonary_circulatio0.70981807
106MP0002108_abnormal_muscle_morphology0.70603176
107MP0005621_abnormal_cell_physiology0.69711673
108MP0001756_abnormal_urination0.69699642
109MP0003279_aneurysm0.69499941
110MP0000534_abnormal_ureter_morphology0.69121244
111MP0005257_abnormal_intraocular_pressure0.69042449
112MP0001177_atelectasis0.68790631
113MP0000371_diluted_coat_color0.68699328
114MP0000604_amyloidosis0.68632727
115MP0004087_abnormal_muscle_fiber0.68318413
116MP0003795_abnormal_bone_structure0.67568755
117MP0003453_abnormal_keratinocyte_physiol0.66947807
118MP0001191_abnormal_skin_condition0.66666592
119MP0001879_abnormal_lymphatic_vessel0.66244336
120MP0003448_altered_tumor_morphology0.65354564
121MP0005408_hypopigmentation0.65241711
122MP0000428_abnormal_craniofacial_morphol0.65077508
123MP0002089_abnormal_postnatal_growth/wei0.64884272
124MP0003221_abnormal_cardiomyocyte_apopto0.63760941
125MP0003690_abnormal_glial_cell0.63703372
126MP0005367_renal/urinary_system_phenotyp0.63520181
127MP0000516_abnormal_urinary_system0.63520181
128MP0005023_abnormal_wound_healing0.63218312
129MP0000163_abnormal_cartilage_morphology0.63145787
130MP0002971_abnormal_brown_adipose0.62647665
131MP0009672_abnormal_birth_weight0.62520906
132MP0004036_abnormal_muscle_relaxation0.62305349
133MP0001835_abnormal_antigen_presentation0.61368702
134MP0004197_abnormal_fetal_growth/weight/0.60475002
135MP0003950_abnormal_plasma_membrane0.60188456
136MP0003632_abnormal_nervous_system0.59133973
137MP0002876_abnormal_thyroid_physiology0.58893640
138MP0001243_abnormal_dermal_layer0.58624721
139MP0005319_abnormal_enzyme/_coenzyme0.58325420
140MP0000377_abnormal_hair_follicle0.58316401
141MP0000538_abnormal_urinary_bladder0.56424949
142MP0000767_abnormal_smooth_muscle0.56011116
143MP0005395_other_phenotype0.55746079

Predicted human phenotypes

RankGene SetZ-score
1Osteolytic defects of the hand bones (HP:0009699)3.20539452
2Osteolytic defects of the phalanges of the hand (HP:0009771)3.20539452
3Periodontitis (HP:0000704)3.07089045
4Subacute progressive viral hepatitis (HP:0006572)3.06740680
5Cardiovascular calcification (HP:0011915)3.04238118
6Asymmetry of the thorax (HP:0001555)3.00438877
7Curly hair (HP:0002212)2.97297639
8Cerebral aneurysm (HP:0004944)2.89724859
9Macroorchidism (HP:0000053)2.84904254
10Aortic aneurysm (HP:0004942)2.81280365
11Deep venous thrombosis (HP:0002625)2.78464838
12Absent frontal sinuses (HP:0002688)2.74774433
13Vascular calcification (HP:0004934)2.69179509
14Tetraparesis (HP:0002273)2.56977200
15Thyroid carcinoma (HP:0002890)2.49393054
16Mitral valve prolapse (HP:0001634)2.48311703
17Abnormality of the common coagulation pathway (HP:0010990)2.43581815
18Aneurysm (HP:0002617)2.41338795
19Aortic dissection (HP:0002647)2.41094492
20Hypoglycemic coma (HP:0001325)2.40900367
21Protrusio acetabuli (HP:0003179)2.37491886
22Premature rupture of membranes (HP:0001788)2.36808863
23Shallow orbits (HP:0000586)2.36369240
24Intrahepatic cholestasis (HP:0001406)2.35642303
25Hypoplastic ischia (HP:0003175)2.34313085
26Abnormality of the ischium (HP:0003174)2.33550753
27Hypoglycemic seizures (HP:0002173)2.32125011
28Hyperinsulinemic hypoglycemia (HP:0000825)2.27856188
29Peritonitis (HP:0002586)2.26955041
30Abnormal foot bone ossification (HP:0010675)2.26918436
31Abnormality of the intrinsic pathway (HP:0010989)2.25251504
32Fair hair (HP:0002286)2.24210725
33Hyperglycemia (HP:0003074)2.23768478
34Xanthomatosis (HP:0000991)2.20008942
35Abnormal biliary tract morphology (HP:0012440)2.19071640
36Back pain (HP:0003418)2.15611267
37Lymphangioma (HP:0100764)2.14685295
38Gingival bleeding (HP:0000225)2.13605992
39Hypobetalipoproteinemia (HP:0003563)2.13558341
40Turricephaly (HP:0000262)2.10334934
41Coarse hair (HP:0002208)2.09831340
42Ulnar bowing (HP:0003031)2.07244958
43Ketoacidosis (HP:0001993)2.06367683
44Abnormality of endocrine pancreas physiology (HP:0012093)2.05004331
45Abnormality of the pancreatic islet cells (HP:0006476)2.05004331
46Mitral stenosis (HP:0001718)2.04947240
47Abnormality of monocarboxylic acid metabolism (HP:0010996)2.04470317
48Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.02135481
49Relative macrocephaly (HP:0004482)2.02041838
50Buphthalmos (HP:0000557)2.00732805
51Submucous cleft hard palate (HP:0000176)2.00476367
52Generalized hypopigmentation of hair (HP:0011358)1.99881329
53Abnormal tarsal ossification (HP:0008369)1.99301880
54Hematochezia (HP:0002573)1.97435304
55Cortical dysplasia (HP:0002539)1.96932595
56Skin nodule (HP:0200036)1.96307889
57Cervical subluxation (HP:0003308)1.94331153
58Deep philtrum (HP:0002002)1.94094799
59Epidermoid cyst (HP:0200040)1.93883229
60Enlarged penis (HP:0000040)1.93778092
61Fat malabsorption (HP:0002630)1.92609470
62Hepatoblastoma (HP:0002884)1.92325585
63Hypoplastic labia majora (HP:0000059)1.92301789
64Dilatation of the ascending aorta (HP:0005111)1.92015523
65Exostoses (HP:0100777)1.91214581
66Hamartoma of the eye (HP:0010568)1.91084909
67Termporal pattern (HP:0011008)1.90680125
68Insidious onset (HP:0003587)1.90680125
69Thin bony cortex (HP:0002753)1.88144971
70Bladder neoplasm (HP:0009725)1.88073580
71Bladder carcinoma (HP:0002862)1.88073580
72Resting tremor (HP:0002322)1.87283083
73Conjugated hyperbilirubinemia (HP:0002908)1.87035631
74Long toe (HP:0010511)1.87031747
75Gingivitis (HP:0000230)1.86913712
76Steatorrhea (HP:0002570)1.85216128
77Right ventricular cardiomyopathy (HP:0011663)1.85125280
78Ankyloglossia (HP:0010296)1.83075281
79Protuberant abdomen (HP:0001538)1.82787841
80Acute myeloid leukemia (HP:0004808)1.82146689
81Lower limb hyperreflexia (HP:0002395)1.81657437
82Tibial bowing (HP:0002982)1.81600846
83Eczematoid dermatitis (HP:0000976)1.81424079
84Wormian bones (HP:0002645)1.81242331
85Testicular neoplasm (HP:0010788)1.80848281
86Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.80139608
87Arterial tortuosity (HP:0005116)1.80003631
88Mildly elevated creatine phosphokinase (HP:0008180)1.79745096
89Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.79159962
90Rectal prolapse (HP:0002035)1.78419073
91Ketosis (HP:0001946)1.78281761
92Abnormality of the labia majora (HP:0012881)1.77538632
93Hyporeflexia of lower limbs (HP:0002600)1.77467856
94Increased CSF protein (HP:0002922)1.77241286
95Orthostatic hypotension (HP:0001278)1.76833302
96Ankle contracture (HP:0006466)1.75909365
97Epiphyseal dysplasia (HP:0002656)1.75868919
98Transitional cell carcinoma of the bladder (HP:0006740)1.75798213
99Abnormal glucose tolerance (HP:0001952)1.75062827
100Hepatocellular carcinoma (HP:0001402)1.74739810
101Glucose intolerance (HP:0000833)1.74629423
102Mucopolysacchariduria (HP:0008155)1.74205073
103Urinary glycosaminoglycan excretion (HP:0003541)1.74205073
104Atrophic scars (HP:0001075)1.73855570
105Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.73621153
106Soft skin (HP:0000977)1.71075792
107Broad metatarsal (HP:0001783)1.70477343
108Abnormality of glutamine family amino acid metabolism (HP:0010902)1.70261561
109Biliary tract neoplasm (HP:0100574)1.69260108
110Glomerulonephritis (HP:0000099)1.68993703
111Follicular hyperkeratosis (HP:0007502)1.68772968
112Spastic diplegia (HP:0001264)1.68596398
113Flat acetabular roof (HP:0003180)1.68329708
114Abdominal distention (HP:0003270)1.67146338
115Renal tubular acidosis (HP:0001947)1.65944900
116Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.65286409
117Vascular tortuosity (HP:0004948)1.64538022
118Myocardial infarction (HP:0001658)1.64217582
119Conjunctival hamartoma (HP:0100780)1.63684362
120Upper limb amyotrophy (HP:0009129)1.63658215
121Distal upper limb amyotrophy (HP:0007149)1.63658215
122Narrow palate (HP:0000189)1.63388022
123Severe short stature (HP:0003510)1.63224947
124Spondylolisthesis (HP:0003302)1.63019365
125Hypolipoproteinemia (HP:0010981)1.62063349
126Exocrine pancreatic insufficiency (HP:0001738)1.61982615
127Hand muscle atrophy (HP:0009130)1.61668205
128Hyperextensible skin (HP:0000974)1.61533867
129Symptomatic seizures (HP:0011145)1.60891874
130Cubitus valgus (HP:0002967)1.60473471
131Abnormality of oral frenula (HP:0000190)1.60347228
132Thoracolumbar scoliosis (HP:0002944)1.59766691
133Striae distensae (HP:0001065)1.58657817
134Overgrowth (HP:0001548)1.58616791
135Cystic hygroma (HP:0000476)1.58615835
136Overlapping toe (HP:0001845)1.58449765
137Spontaneous hematomas (HP:0007420)1.57954934
138Spinal cord lesions (HP:0100561)1.57763021
139Syringomyelia (HP:0003396)1.57763021
140Focal segmental glomerulosclerosis (HP:0000097)1.57226528
141Sandal gap (HP:0001852)1.57219267
142Complement deficiency (HP:0004431)1.57169802
143Blue irides (HP:0000635)1.57054375
144Infantile muscular hypotonia (HP:0008947)1.55825404
145Pancreatic islet-cell hyperplasia (HP:0004510)1.55571451
146Papilledema (HP:0001085)1.55450526
147Congenital glaucoma (HP:0001087)1.55321591
148Papillary thyroid carcinoma (HP:0002895)1.54953984
149Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.54549440
150Visceral angiomatosis (HP:0100761)1.53757285
151Bowel diverticulosis (HP:0005222)1.53508050
152Hypoalphalipoproteinemia (HP:0003233)1.53507737
153Small epiphyses (HP:0010585)1.53068083
154Cupped ribs (HP:0000887)1.52762114
155Vertebral clefting (HP:0008428)1.52501592

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.06782097
2LATS13.29654582
3TRIB33.10740958
4ACVR1B2.73841441
5MAP3K102.57456388
6ERN12.56052900
7SIK12.55475905
8PKN22.48532852
9TAOK32.44736628
10ERBB32.38911052
11MAP3K22.33250969
12SCYL22.17006982
13RIPK12.05597095
14PTK62.02882924
15PDGFRA1.97737645
16INSRR1.96941061
17MAP3K141.84150247
18CASK1.78494364
19FGFR21.78075261
20BMPR21.72421982
21TTN1.67929509
22TYK21.60702735
23DDR21.59633484
24YES11.58148476
25SGK21.57340752
26EIF2AK31.57142148
27CAMK1D1.55793418
28CAMK1G1.55200263
29EEF2K1.50599103
30CAMKK21.46853219
31NLK1.45142682
32RET1.37776117
33STK31.28517948
34PAK31.23253889
35FER1.22407022
36MST41.21972528
37PDGFRB1.18481746
38EIF2AK11.15465868
39AKT31.14933542
40FGFR31.13254420
41MET1.11467242
42STK391.09126493
43LMTK21.08805193
44WNK11.08695989
45STK241.08347426
46MTOR1.08143490
47CDK121.07421045
48PTK21.05609726
49JAK11.05043408
50FGFR41.02444348
51BRSK21.00133481
52EPHB10.94271395
53PLK20.94248394
54NTRK10.93506535
55EPHA30.90843227
56MAP3K10.90295949
57PAK20.89960648
58MAP3K70.88978084
59KSR20.88559329
60WNK40.87857352
61PRKCH0.87794114
62CDK60.86589280
63DYRK1B0.86468915
64BMX0.85266583
65LRRK20.83877818
66MST1R0.83164590
67HIPK20.82791952
68TEC0.81951516
69PIK3CA0.81901772
70BCR0.79764016
71MAP3K130.79044760
72SGK30.78871501
73FGFR10.77933158
74BLK0.76231503
75BRD40.76163094
76NUAK10.75315948
77MAP3K40.74890321
78MAP3K120.74769253
79PNCK0.73273881
80PRKAA10.72733850
81DMPK0.72213997
82MAP2K10.70949726
83IRAK10.70629908
84ERBB40.67238183
85MAP2K30.66489125
86CAMKK10.64309924
87PTK2B0.64289397
88BCKDK0.63727464
89ZAP700.62226207
90GSK3A0.62148276
91MAP3K90.61620781
92RIPK40.60874348
93SGK4940.60614148
94SGK2230.60614148
95JAK20.60555446
96MAP2K40.60157149
97PAK60.59781075
98PRKD10.59416122
99PDPK10.59397996
100WNK30.59303585
101PDK20.59289261
102IRAK40.59168381
103STK38L0.59109923
104IRAK30.58550010
105FLT30.57905033
106MAP3K30.56245320
107PIK3CG0.55001347
108RAF10.54915638
109OXSR10.54045513
110RPS6KB10.53308263
111MAP3K60.53266977
112MELK0.52606235
113STK380.52043849
114ALK0.50922455
115PRKD30.50374642
116BMPR1B0.49995607
117GRK60.49833610
118EGFR0.49475620
119ERBB20.48062293
120KSR10.48046648
121JAK30.48025235
122CDC42BPA0.47259649
123CSNK1G20.46135292
124STK100.45906007
125LATS20.45702337
126CDK90.45459818
127CSNK1A1L0.44875973
128NEK60.44827389
129PDK10.44679649
130SGK10.44245267
131INSR0.43316648
132ROCK10.43126933
133PRKCE0.42533519
134CLK10.42467248
135CSNK1D0.41180701
136MKNK20.40253809
137PRKAA20.40234988
138MARK20.40166562
139STK40.38749270
140FYN0.38468464
141TRPM70.37796806
142TGFBR20.35532562
143STK110.35062887
144SIK30.34594239
145NEK90.34419456
146ICK0.34101567
147PDK30.33045137
148PDK40.33045137

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.26391780
2Maturity onset diabetes of the young_Homo sapiens_hsa049502.36978613
3Sulfur metabolism_Homo sapiens_hsa009201.86194342
4* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.72825272
5Type II diabetes mellitus_Homo sapiens_hsa049301.54613578
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.52202784
7Arginine biosynthesis_Homo sapiens_hsa002201.50145636
8Bile secretion_Homo sapiens_hsa049761.47073163
9Primary bile acid biosynthesis_Homo sapiens_hsa001201.44837748
10Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.43198148
11Circadian rhythm_Homo sapiens_hsa047101.34678223
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.33836047
13Protein digestion and absorption_Homo sapiens_hsa049741.33491076
14Fat digestion and absorption_Homo sapiens_hsa049751.27661340
15Insulin resistance_Homo sapiens_hsa049311.27588532
16Lysine degradation_Homo sapiens_hsa003101.23822391
17Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.23511602
18Carbohydrate digestion and absorption_Homo sapiens_hsa049731.22294373
19mTOR signaling pathway_Homo sapiens_hsa041501.19033645
20Fatty acid degradation_Homo sapiens_hsa000711.18209666
21Tryptophan metabolism_Homo sapiens_hsa003801.17180301
22Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.15968521
23Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.10945838
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.09274065
25Focal adhesion_Homo sapiens_hsa045101.08286648
26Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.06632390
27Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.06294663
28Other glycan degradation_Homo sapiens_hsa005111.05827776
29Pancreatic secretion_Homo sapiens_hsa049721.05419125
30ECM-receptor interaction_Homo sapiens_hsa045121.03596113
31Thyroid cancer_Homo sapiens_hsa052161.02353595
32Insulin secretion_Homo sapiens_hsa049111.00640194
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.00576698
34Starch and sucrose metabolism_Homo sapiens_hsa005000.99832071
35Thyroid hormone synthesis_Homo sapiens_hsa049180.99153806
36Glycosaminoglycan degradation_Homo sapiens_hsa005310.98247481
37Butanoate metabolism_Homo sapiens_hsa006500.97775842
38Caffeine metabolism_Homo sapiens_hsa002320.97743433
39Adherens junction_Homo sapiens_hsa045200.97096354
40PPAR signaling pathway_Homo sapiens_hsa033200.96869656
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.94511481
42Complement and coagulation cascades_Homo sapiens_hsa046100.91370668
43Fatty acid biosynthesis_Homo sapiens_hsa000610.90747834
44Jak-STAT signaling pathway_Homo sapiens_hsa046300.90451022
45Proteoglycans in cancer_Homo sapiens_hsa052050.90396952
46Fatty acid metabolism_Homo sapiens_hsa012120.89977721
47Selenocompound metabolism_Homo sapiens_hsa004500.89870590
48Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.89747136
49Mineral absorption_Homo sapiens_hsa049780.89445149
50Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.86401520
51Chronic myeloid leukemia_Homo sapiens_hsa052200.81189503
52ABC transporters_Homo sapiens_hsa020100.81119121
53Renin-angiotensin system_Homo sapiens_hsa046140.80959740
54Propanoate metabolism_Homo sapiens_hsa006400.80856205
55Glioma_Homo sapiens_hsa052140.80780916
56Dorso-ventral axis formation_Homo sapiens_hsa043200.80673500
57Estrogen signaling pathway_Homo sapiens_hsa049150.80515411
58Sphingolipid metabolism_Homo sapiens_hsa006000.80257462
59Endometrial cancer_Homo sapiens_hsa052130.79402529
60N-Glycan biosynthesis_Homo sapiens_hsa005100.79375783
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.78510437
62Prostate cancer_Homo sapiens_hsa052150.78362026
63AMPK signaling pathway_Homo sapiens_hsa041520.78283720
64Amoebiasis_Homo sapiens_hsa051460.77904342
65Glycerolipid metabolism_Homo sapiens_hsa005610.77493052
66Protein export_Homo sapiens_hsa030600.77269660
67Glucagon signaling pathway_Homo sapiens_hsa049220.76823601
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.76216638
69Acute myeloid leukemia_Homo sapiens_hsa052210.75780238
70Pancreatic cancer_Homo sapiens_hsa052120.74945058
71Aldosterone synthesis and secretion_Homo sapiens_hsa049250.73699140
72Retinol metabolism_Homo sapiens_hsa008300.73203705
73Longevity regulating pathway - mammal_Homo sapiens_hsa042110.72056350
74Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.70662767
75Hepatitis C_Homo sapiens_hsa051600.69053998
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69028854
77Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68523774
78Central carbon metabolism in cancer_Homo sapiens_hsa052300.67898593
79Insulin signaling pathway_Homo sapiens_hsa049100.67750421
80Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.67626232
81Renal cell carcinoma_Homo sapiens_hsa052110.67030678
82Osteoclast differentiation_Homo sapiens_hsa043800.66716519
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.66660371
84Leukocyte transendothelial migration_Homo sapiens_hsa046700.65990461
85Measles_Homo sapiens_hsa051620.64995257
86Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.63509754
87Hepatitis B_Homo sapiens_hsa051610.63293639
88Non-small cell lung cancer_Homo sapiens_hsa052230.62778147
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62751015
90Small cell lung cancer_Homo sapiens_hsa052220.61690579
91Melanoma_Homo sapiens_hsa052180.61122409
92Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.60974998
93Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.60909143
94PI3K-Akt signaling pathway_Homo sapiens_hsa041510.60240128
95Renin secretion_Homo sapiens_hsa049240.59177906
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.58695222
97cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58565942
98Legionellosis_Homo sapiens_hsa051340.58439850
99Bladder cancer_Homo sapiens_hsa052190.58362357
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.58299234
101Toxoplasmosis_Homo sapiens_hsa051450.58225029
102Gastric acid secretion_Homo sapiens_hsa049710.57912297
1032-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.57780343
104Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57140874
105Prolactin signaling pathway_Homo sapiens_hsa049170.56296692
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.56092083
107GnRH signaling pathway_Homo sapiens_hsa049120.55684753
108Dilated cardiomyopathy_Homo sapiens_hsa054140.54188033
109Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53717499
110MicroRNAs in cancer_Homo sapiens_hsa052060.53666699
111Choline metabolism in cancer_Homo sapiens_hsa052310.53480151
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53360104
113NOD-like receptor signaling pathway_Homo sapiens_hsa046210.53186889
114FoxO signaling pathway_Homo sapiens_hsa040680.52349340
115B cell receptor signaling pathway_Homo sapiens_hsa046620.52300720
116TNF signaling pathway_Homo sapiens_hsa046680.50919368
117Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50263101
118Cocaine addiction_Homo sapiens_hsa050300.49885383
119TGF-beta signaling pathway_Homo sapiens_hsa043500.49623885
120Tight junction_Homo sapiens_hsa045300.49202588
121Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.49186881
122Lysosome_Homo sapiens_hsa041420.48429516
123Inositol phosphate metabolism_Homo sapiens_hsa005620.48315826
124Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.47361316
125HIF-1 signaling pathway_Homo sapiens_hsa040660.47318119
126Neurotrophin signaling pathway_Homo sapiens_hsa047220.46512031
127Salivary secretion_Homo sapiens_hsa049700.46434260
128Chemical carcinogenesis_Homo sapiens_hsa052040.46102138
129Histidine metabolism_Homo sapiens_hsa003400.45245918
130Hippo signaling pathway_Homo sapiens_hsa043900.44416465
131Prion diseases_Homo sapiens_hsa050200.43818413
132Long-term potentiation_Homo sapiens_hsa047200.43651588
133Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.43446985
134AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.43302652
135Systemic lupus erythematosus_Homo sapiens_hsa053220.42058908
136Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.41833605
137ErbB signaling pathway_Homo sapiens_hsa040120.41715320
138Cholinergic synapse_Homo sapiens_hsa047250.40727955
139Platelet activation_Homo sapiens_hsa046110.40717874

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