EDF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that may regulate endothelial cell differentiation, lipid metabolism, and hormone-induced cardiomyocyte hypertrophy. The encoded protein has also been found to act as a transcriptional coactivator by interconnecting the general transcription factor TATA element-binding protein (TBP) and gene-specific activators. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.20786029
2GDP-mannose metabolic process (GO:0019673)4.96591530
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.93834544
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.84716073
5L-phenylalanine metabolic process (GO:0006558)4.84716073
6protein maturation by protein folding (GO:0022417)4.70264881
7protein complex disassembly (GO:0043241)4.56469481
8ATP synthesis coupled proton transport (GO:0015986)4.51534105
9energy coupled proton transport, down electrochemical gradient (GO:0015985)4.51534105
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.49696287
11L-phenylalanine catabolic process (GO:0006559)4.49696287
12deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.35187592
13negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.30924869
14maturation of SSU-rRNA (GO:0030490)4.29799684
15macromolecular complex disassembly (GO:0032984)4.25060452
16protein targeting to membrane (GO:0006612)4.23273168
17chaperone-mediated protein transport (GO:0072321)4.12668208
18ribosomal large subunit biogenesis (GO:0042273)4.07696791
19aldehyde catabolic process (GO:0046185)4.03924692
20translation (GO:0006412)4.00462002
21cysteine metabolic process (GO:0006534)3.98832439
22respiratory electron transport chain (GO:0022904)3.97795268
23triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.94946314
24glyoxylate metabolic process (GO:0046487)3.91780348
25sulfur amino acid catabolic process (GO:0000098)3.88363151
26electron transport chain (GO:0022900)3.88342564
27aromatic amino acid family catabolic process (GO:0009074)3.84737380
28mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.74011711
29viral transcription (GO:0019083)3.61435045
30ribonucleoprotein complex biogenesis (GO:0022613)3.59072265
31oxidative phosphorylation (GO:0006119)3.55134106
32protein targeting to mitochondrion (GO:0006626)3.48992743
33lysine metabolic process (GO:0006553)3.48690503
34lysine catabolic process (GO:0006554)3.48690503
35translational termination (GO:0006415)3.46240255
36kynurenine metabolic process (GO:0070189)3.41767761
37nucleobase-containing small molecule interconversion (GO:0015949)3.40995896
38establishment of protein localization to mitochondrial membrane (GO:0090151)3.39942133
39bile acid and bile salt transport (GO:0015721)3.37259030
40establishment of protein localization to membrane (GO:0090150)3.32447926
41regulation of cholesterol esterification (GO:0010872)3.32261118
42establishment of protein localization to mitochondrion (GO:0072655)3.31280998
43purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.27519728
44regulation of triglyceride catabolic process (GO:0010896)3.27403247
45GTP biosynthetic process (GO:0006183)3.26859799
46tryptophan catabolic process (GO:0006569)3.26752059
47indole-containing compound catabolic process (GO:0042436)3.26752059
48indolalkylamine catabolic process (GO:0046218)3.26752059
49positive regulation of triglyceride lipase activity (GO:0061365)3.25759457
50positive regulation of lipoprotein lipase activity (GO:0051006)3.25759457
51serine family amino acid catabolic process (GO:0009071)3.24473036
52guanosine-containing compound biosynthetic process (GO:1901070)3.23732119
53glycine metabolic process (GO:0006544)3.22862183
54purine nucleoside triphosphate biosynthetic process (GO:0009145)3.20874308
55cellular component biogenesis (GO:0044085)3.20676285
56cellular ketone body metabolic process (GO:0046950)3.20024951
57SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.19016550
58serine family amino acid biosynthetic process (GO:0009070)3.16804759
59aromatic amino acid family metabolic process (GO:0009072)3.15893281
60UTP biosynthetic process (GO:0006228)3.15494103
61protein targeting to ER (GO:0045047)3.14792526
62regulation of mitochondrial translation (GO:0070129)3.14611621
63serine family amino acid metabolic process (GO:0009069)3.14568533
64nuclear-transcribed mRNA catabolic process (GO:0000956)3.14387378
65homocysteine metabolic process (GO:0050667)3.13832864
66ribonucleoside triphosphate biosynthetic process (GO:0009201)3.12710629
67bile acid biosynthetic process (GO:0006699)3.12034160
68formation of translation preinitiation complex (GO:0001731)3.11486124
69cotranslational protein targeting to membrane (GO:0006613)3.11152659
70translational elongation (GO:0006414)3.11126092
71pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.10978449
72DNA deamination (GO:0045006)3.10270401
73protein retention in ER lumen (GO:0006621)3.09401344
74high-density lipoprotein particle remodeling (GO:0034375)3.08506139
75fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.07359167
76ribosomal small subunit biogenesis (GO:0042274)3.06288495
77intestinal cholesterol absorption (GO:0030299)3.04700590
78protein localization to endoplasmic reticulum (GO:0070972)3.04427218
79Golgi transport vesicle coating (GO:0048200)3.03301275
80COPI coating of Golgi vesicle (GO:0048205)3.03301275
81proline biosynthetic process (GO:0006561)3.03251082
82viral protein processing (GO:0019082)3.03184313
83protein localization to mitochondrion (GO:0070585)3.01803746
84mRNA catabolic process (GO:0006402)2.99855746
85protein targeting (GO:0006605)2.99257438
86phospholipid efflux (GO:0033700)2.98254402
87tryptophan metabolic process (GO:0006568)2.98119557
88nucleotide salvage (GO:0043173)2.95955257
89amino-acid betaine metabolic process (GO:0006577)2.94705301
90ribosomal small subunit assembly (GO:0000028)2.94604915
91establishment of protein localization to endoplasmic reticulum (GO:0072599)2.94436375
92pentose metabolic process (GO:0019321)2.91352080
93alpha-linolenic acid metabolic process (GO:0036109)2.90985435
94protein complex biogenesis (GO:0070271)2.89204690
95negative regulation of fibrinolysis (GO:0051918)2.87744854
96CTP metabolic process (GO:0046036)2.87001213
97CTP biosynthetic process (GO:0006241)2.87001213
98fatty acid beta-oxidation (GO:0006635)2.85868948
99cofactor catabolic process (GO:0051187)2.85566680
100deoxyribonucleotide catabolic process (GO:0009264)2.83536532
101alpha-amino acid catabolic process (GO:1901606)2.83434165
102viral life cycle (GO:0019058)2.83271787
103nucleoside diphosphate biosynthetic process (GO:0009133)2.83037898
104purine deoxyribonucleotide catabolic process (GO:0009155)2.82049731
105UTP metabolic process (GO:0046051)2.81895406
106pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.81007021
107plasma lipoprotein particle remodeling (GO:0034369)2.80476129
108protein-lipid complex remodeling (GO:0034368)2.80476129
109macromolecular complex remodeling (GO:0034367)2.80476129
110pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.80198576
111virion assembly (GO:0019068)2.80156029
112aspartate family amino acid catabolic process (GO:0009068)2.80027859
113nucleoside salvage (GO:0043174)2.79712990
114protein carboxylation (GO:0018214)2.79254480
115peptidyl-glutamic acid carboxylation (GO:0017187)2.79254480
116ATP biosynthetic process (GO:0006754)2.79196566
117urea metabolic process (GO:0019627)2.78612369
118urea cycle (GO:0000050)2.78612369
119flavonoid metabolic process (GO:0009812)2.78316096
120negative regulation of cholesterol transport (GO:0032375)2.78019207
121negative regulation of sterol transport (GO:0032372)2.78019207
122hydrogen ion transmembrane transport (GO:1902600)2.77432522
123glucuronate metabolic process (GO:0019585)2.76779236
124uronic acid metabolic process (GO:0006063)2.76779236
125regulation of cellular amino acid metabolic process (GO:0006521)2.76446131
126heme transport (GO:0015886)2.76406782
127nucleoside triphosphate biosynthetic process (GO:0009142)2.75795221
128plasma lipoprotein particle clearance (GO:0034381)2.75373668
129L-serine metabolic process (GO:0006563)2.74856165
130NADH metabolic process (GO:0006734)2.74367665
1312-oxoglutarate metabolic process (GO:0006103)2.74173808
132cellular amino acid catabolic process (GO:0009063)2.74132006
133maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.73959312
134nitrogen cycle metabolic process (GO:0071941)2.73829523
135fatty acid catabolic process (GO:0009062)2.72962836
136RNA catabolic process (GO:0006401)2.72866823
137pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.72752422
138protein insertion into membrane (GO:0051205)2.71982583
139ketone body metabolic process (GO:1902224)2.71764867
140cellular glucuronidation (GO:0052695)2.71678910
141acetyl-CoA metabolic process (GO:0006084)2.71597551
142deoxyribose phosphate biosynthetic process (GO:0046385)2.69908226
1432-deoxyribonucleotide biosynthetic process (GO:0009265)2.69908226
144mitochondrial transport (GO:0006839)2.69874580
145regulation of protein activation cascade (GO:2000257)2.69717100
146regulation of cholesterol metabolic process (GO:0090181)2.69633449
147cellular protein complex disassembly (GO:0043624)2.68830687
148aerobic respiration (GO:0009060)2.68330080
149transcription elongation from RNA polymerase III promoter (GO:0006385)2.67438399
150termination of RNA polymerase III transcription (GO:0006386)2.67438399
151deoxyribose phosphate catabolic process (GO:0046386)2.66582923
152mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.65970480
153mitochondrial respiratory chain complex I assembly (GO:0032981)2.65970480
154NADH dehydrogenase complex assembly (GO:0010257)2.65970480
155nuclear envelope reassembly (GO:0031468)2.65542693
156mitotic nuclear envelope reassembly (GO:0007084)2.65542693
157monocarboxylic acid catabolic process (GO:0072329)2.64438558
158triglyceride homeostasis (GO:0070328)2.64358017
159acylglycerol homeostasis (GO:0055090)2.64358017
160mitochondrial respiratory chain complex assembly (GO:0033108)2.63882890
161bile acid metabolic process (GO:0008206)2.63727850
162translational initiation (GO:0006413)2.63611436
163benzene-containing compound metabolic process (GO:0042537)2.63482423
164regulation of fibrinolysis (GO:0051917)2.63445185
165heme metabolic process (GO:0042168)2.62962723
166organic acid catabolic process (GO:0016054)2.62768463
167carboxylic acid catabolic process (GO:0046395)2.62768463
168reverse cholesterol transport (GO:0043691)2.62557275
169protein localization to membrane (GO:0072657)2.62075395
170positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.59838964
171negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.59754844
172UV protection (GO:0009650)2.59691713
173pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.58505419
174pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.58065196
175negative regulation of ligase activity (GO:0051352)2.55745277
176negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.55745277

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.67145100
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.39604968
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.68972503
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.57443174
5* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.54694804
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.01451644
7EGR1_23403033_ChIP-Seq_LIVER_Mouse2.57700944
8LXR_22158963_ChIP-Seq_LIVER_Mouse2.40676849
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.38519851
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.34879425
11SRY_22984422_ChIP-ChIP_TESTIS_Rat2.31038878
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.23387235
13* FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.18260530
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.17280194
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.17213981
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.15087092
17MYC_18555785_ChIP-Seq_MESCs_Mouse2.11440775
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.09050892
19ETS1_20019798_ChIP-Seq_JURKAT_Human2.07645472
20HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.97490283
21* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95895043
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.94295765
23MYC_18358816_ChIP-ChIP_MESCs_Mouse1.88803462
24EST1_17652178_ChIP-ChIP_JURKAT_Human1.87779356
25CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.80553972
26CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.78951917
27ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.70793897
28ZNF263_19887448_ChIP-Seq_K562_Human1.68046546
29STAT3_1855785_ChIP-Seq_MESCs_Mouse1.64658684
30TP63_17297297_ChIP-ChIP_HaCaT_Human1.63507324
31ELF1_17652178_ChIP-ChIP_JURKAT_Human1.57017169
32DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.56038814
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.53907973
34CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.53296319
35TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52946035
36E2F1_18555785_ChIP-Seq_MESCs_Mouse1.52330804
37IRF8_22096565_ChIP-ChIP_GC-B_Human1.51262479
38XRN2_22483619_ChIP-Seq_HELA_Human1.50896295
39NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.49798192
40PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.45278249
41DCP1A_22483619_ChIP-Seq_HELA_Human1.42800290
42NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.42347080
43* LXR_22292898_ChIP-Seq_THP-1_Human1.40466815
44SRF_21415370_ChIP-Seq_HL-1_Mouse1.38290365
45SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.36628310
46ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.34922352
47BP1_19119308_ChIP-ChIP_Hs578T_Human1.34595110
48MYC_19079543_ChIP-ChIP_MESCs_Mouse1.30466092
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.27969032
50TET1_21451524_ChIP-Seq_MESCs_Mouse1.27918018
51ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.27610028
52E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.27592515
53SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.27102668
54ERG_21242973_ChIP-ChIP_JURKAT_Human1.27098645
55STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.26504366
56OCT4_18692474_ChIP-Seq_MEFs_Mouse1.25923488
57HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.25797547
58* BCL6_27268052_Chip-Seq_Bcells_Human1.25470691
59MYC_22102868_ChIP-Seq_BL_Human1.25216147
60* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.23871272
61FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.23334542
62POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.22943324
63SA1_27219007_Chip-Seq_Bcells_Human1.22823604
64KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.21111709
65TTF2_22483619_ChIP-Seq_HELA_Human1.21042199
66GABP_19822575_ChIP-Seq_HepG2_Human1.20478856
67SMC4_20622854_ChIP-Seq_HELA_Human1.19176657
68CTCF_27219007_Chip-Seq_ERYTHROID_Human1.17338132
69* BCOR_27268052_Chip-Seq_Bcells_Human1.16364556
70HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.15794653
71TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.15587471
72CTCF_18555785_ChIP-Seq_MESCs_Mouse1.13339900
73UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.13137441
74KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12808104
75ELK3_25401928_ChIP-Seq_HUVEC_Human1.10221099
76SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.09535795
77RACK7_27058665_Chip-Seq_MCF-7_Human1.09356902
78BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.08687484
79CTCF_20526341_ChIP-Seq_ESCs_Human1.08371365
80SOX2_18692474_ChIP-Seq_MEFs_Mouse1.07975426
81RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.07886273
82SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.07410284
83YY1_22570637_ChIP-Seq_MALME-3M_Human1.06558630
84E2F1_20622854_ChIP-Seq_HELA_Human1.06463046
85CTCF_26484167_Chip-Seq_Bcells_Mouse1.05810561
86KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.05616682
87CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.04584145
88CTCF_27219007_Chip-Seq_Bcells_Human1.03697875
89VDR_23849224_ChIP-Seq_CD4+_Human1.03285738
90ELF1_20517297_ChIP-Seq_JURKAT_Human1.03283904
91PU.1_20513432_ChIP-Seq_Bcells_Mouse1.03128773
92MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.01679419
93NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.01474692
94* MAF_26560356_Chip-Seq_TH2_Human1.01359680
95ELK1_22589737_ChIP-Seq_MCF10A_Human1.01315117
96* ATF3_27146783_Chip-Seq_COLON_Human1.00757828
97VDR_21846776_ChIP-Seq_THP-1_Human1.00396980
98RARA_24833708_ChIP-Seq_LIVER_Mouse0.99858508
99KDM2B_26808549_Chip-Seq_SUP-B15_Human0.99568689
100ESR1_15608294_ChIP-ChIP_MCF-7_Human0.99070119
101HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.98931765
102SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98661733
103KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.98246490
104* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.97977013
105THAP11_20581084_ChIP-Seq_MESCs_Mouse0.97311685
106* CLOCK_20551151_ChIP-Seq_293T_Human0.97078105
107SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.96543387
108* P68_20966046_ChIP-Seq_HELA_Human0.95890501
109IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.95869960
110CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.95638163
111ZFX_18555785_ChIP-Seq_MESCs_Mouse0.95108063
112ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93932071
113RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.93854954
114SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.93829303
115SA1_27219007_Chip-Seq_ERYTHROID_Human0.93368486
116GATA1_22383799_ChIP-Seq_G1ME_Mouse0.93188101
117* NELFA_20434984_ChIP-Seq_ESCs_Mouse0.93162339
118* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.92780097
119FOXP1_21924763_ChIP-Seq_HESCs_Human0.92042213
120PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.91867550
121SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.91398153
122TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.91216700
123CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.89134151
124PHF8_20622854_ChIP-Seq_HELA_Human0.88999692
125SOX2_27498859_Chip-Seq_STOMACH_Mouse0.88912730
126NANOG_18555785_ChIP-Seq_MESCs_Mouse0.87817670

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.71341200
2MP0002139_abnormal_hepatobiliary_system5.50779723
3MP0003806_abnormal_nucleotide_metabolis4.62841376
4MP0005085_abnormal_gallbladder_physiolo4.21487336
5MP0005365_abnormal_bile_salt3.78681069
6MP0009840_abnormal_foam_cell3.78158185
7MP0008875_abnormal_xenobiotic_pharmacok3.52458777
8MP0005083_abnormal_biliary_tract3.34650116
9MP0004858_abnormal_nervous_system2.89092990
10MP0001666_abnormal_nutrient_absorption2.76473798
11MP0003186_abnormal_redox_activity2.60121138
12MP0005332_abnormal_amino_acid2.55445871
13MP0003191_abnormal_cellular_cholesterol2.45998242
14MP0010329_abnormal_lipoprotein_level2.35747823
15MP0003252_abnormal_bile_duct2.17219486
16MP0010030_abnormal_orbit_morphology2.16134383
17MP0003123_paternal_imprinting2.06967419
18MP0003195_calcinosis2.04932825
19MP0000678_abnormal_parathyroid_gland2.02982952
20MP0006036_abnormal_mitochondrial_physio1.95379586
21MP0004019_abnormal_vitamin_homeostasis1.90883037
22MP0009643_abnormal_urine_homeostasis1.90313334
23MP0005319_abnormal_enzyme/_coenzyme1.87750433
24MP0003879_abnormal_hair_cell1.76872675
25MP0005451_abnormal_body_composition1.75885882
26MP0008260_abnormal_autophagy1.75454172
27MP0002138_abnormal_hepatobiliary_system1.73907790
28MP0000609_abnormal_liver_physiology1.62280966
29MP0005584_abnormal_enzyme/coenzyme_acti1.62111858
30MP0005636_abnormal_mineral_homeostasis1.57104421
31MP0003656_abnormal_erythrocyte_physiolo1.56471580
32MP0002118_abnormal_lipid_homeostasis1.53835470
33MP0001764_abnormal_homeostasis1.50246193
34MP0003075_altered_response_to1.48945413
35MP0000490_abnormal_crypts_of1.46838075
36MP0003705_abnormal_hypodermis_morpholog1.43287335
37MP0005084_abnormal_gallbladder_morpholo1.39896229
38MP0009785_altered_susceptibility_to1.39779571
39MP0002837_dystrophic_cardiac_calcinosis1.39557298
40MP0009379_abnormal_foot_pigmentation1.37776404
41MP0000681_abnormal_thyroid_gland1.31748338
42MP0008469_abnormal_protein_level1.30294239
43MP0003436_decreased_susceptibility_to1.30084404
44MP0002653_abnormal_ependyma_morphology1.27555452
45MP0006035_abnormal_mitochondrial_morpho1.27101810
46MP0001756_abnormal_urination1.26358123
47MP0005058_abnormal_lysosome_morphology1.18089370
48MP0002249_abnormal_larynx_morphology1.17923570
49MP0010234_abnormal_vibrissa_follicle1.17095921
50MP0002822_catalepsy1.11984098
51MP0001905_abnormal_dopamine_level1.08320623
52MP0002877_abnormal_melanocyte_morpholog1.08290877
53MP0003724_increased_susceptibility_to1.04995291
54MP0004957_abnormal_blastocyst_morpholog1.04833254
55MP0000598_abnormal_liver_morphology1.04712551
56MP0009764_decreased_sensitivity_to1.02924816
57MP0000685_abnormal_immune_system1.02296879
58MP0003011_delayed_dark_adaptation1.00672549
59MP0005167_abnormal_blood-brain_barrier1.00399969
60MP0005025_abnormal_response_to1.00030692
61MP0005670_abnormal_white_adipose0.99043199
62MP0002089_abnormal_postnatal_growth/wei0.99027507
63MP0001853_heart_inflammation0.97602528
64MP0002136_abnormal_kidney_physiology0.95131416
65MP0004185_abnormal_adipocyte_glucose0.95070052
66MP0002148_abnormal_hypersensitivity_rea0.95051201
67MP0006082_CNS_inflammation0.93985376
68MP0002132_abnormal_respiratory_system0.93757230
69MP0003453_abnormal_keratinocyte_physiol0.93534161
70MP0002796_impaired_skin_barrier0.93110759
71MP0005330_cardiomyopathy0.91820703
72MP0001348_abnormal_lacrimal_gland0.91022000
73MP0009333_abnormal_splenocyte_physiolog0.90996542
74MP0000750_abnormal_muscle_regeneration0.90241913
75MP0008438_abnormal_cutaneous_collagen0.90125764
76MP0005266_abnormal_metabolism0.89350579
77MP0003646_muscle_fatigue0.88341757
78MP0009642_abnormal_blood_homeostasis0.88162720
79MP0000604_amyloidosis0.87993809
80MP0003866_abnormal_defecation0.87983204
81MP0004947_skin_inflammation0.87198373
82MP0005376_homeostasis/metabolism_phenot0.86515858
83MP0001835_abnormal_antigen_presentation0.85983770
84MP0001845_abnormal_inflammatory_respons0.85334423
85MP0001849_ear_inflammation0.85203473
86MP0000358_abnormal_cell_content/0.84755795
87MP0001727_abnormal_embryo_implantation0.84137249
88MP0005257_abnormal_intraocular_pressure0.83962268
89MP0000747_muscle_weakness0.83715223
90MP0004043_abnormal_pH_regulation0.83087480
91MP0002163_abnormal_gland_morphology0.80044520
92MP0003693_abnormal_embryo_hatching0.79263244
93MP0003638_abnormal_response/metabolism_0.78690813
94MP0009763_increased_sensitivity_to0.78575615
95MP0004233_abnormal_muscle_weight0.78268458
96MP0005165_increased_susceptibility_to0.78105415
97MP0001881_abnormal_mammary_gland0.78044116
98MP0008874_decreased_physiological_sensi0.77356508
99MP0004510_myositis0.76814831
100MP0008932_abnormal_embryonic_tissue0.76057783
101MP0000538_abnormal_urinary_bladder0.75887971
102MP0004782_abnormal_surfactant_physiolog0.74079352
103MP0001663_abnormal_digestive_system0.73169589
104MP0005535_abnormal_body_temperature0.72872625
105MP0000343_altered_response_to0.72028215
106MP0008873_increased_physiological_sensi0.71409199
107MP0010155_abnormal_intestine_physiology0.70291271
108MP0009278_abnormal_bone_marrow0.69357045
109MP0005166_decreased_susceptibility_to0.69167369
110MP0000313_abnormal_cell_death0.67859892
111MP0000749_muscle_degeneration0.67562917
112MP0008872_abnormal_physiological_respon0.66720265
113MP0000003_abnormal_adipose_tissue0.66681800
114MP0003718_maternal_effect0.66100755
115MP0005023_abnormal_wound_healing0.65866690
116MP0003786_premature_aging0.65247578
117MP0005375_adipose_tissue_phenotype0.64873398
118MP0002269_muscular_atrophy0.63635735
119MP0003868_abnormal_feces_composition0.63504305
120MP0005000_abnormal_immune_tolerance0.63473788
121MP0005377_hearing/vestibular/ear_phenot0.63136291
122MP0003878_abnormal_ear_physiology0.63136291
123MP0000858_altered_metastatic_potential0.61889813
124MP0003221_abnormal_cardiomyocyte_apopto0.61337593
125MP0003315_abnormal_perineum_morphology0.61125531
126MP0003329_amyloid_beta_deposits0.60688249
127MP0000537_abnormal_urethra_morphology0.59450359
128MP0000477_abnormal_intestine_morphology0.58512262
129MP0001542_abnormal_bone_strength0.58339656
130MP0010771_integument_phenotype0.57208950
131MP0000249_abnormal_blood_vessel0.57022614
132MP0005408_hypopigmentation0.56866119
133MP0005501_abnormal_skin_physiology0.56832349
134MP0001243_abnormal_dermal_layer0.56673694
135MP0001873_stomach_inflammation0.56270686
136MP0002876_abnormal_thyroid_physiology0.56119704
137MP0005666_abnormal_adipose_tissue0.56107888
138MP0005381_digestive/alimentary_phenotyp0.55811645
139MP0001765_abnormal_ion_homeostasis0.55667847
140MP0004084_abnormal_cardiac_muscle0.55448161

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)4.88104667
2Abnormality of monocarboxylic acid metabolism (HP:0010996)3.96763880
3Reticulocytopenia (HP:0001896)3.95353354
4Xanthomatosis (HP:0000991)3.81218679
5Acute encephalopathy (HP:0006846)3.73532424
6Hepatic necrosis (HP:0002605)3.73405866
7Hypobetalipoproteinemia (HP:0003563)3.72994246
8Acute necrotizing encephalopathy (HP:0006965)3.65009694
9Intrahepatic cholestasis (HP:0001406)3.55282830
10Cerebral edema (HP:0002181)3.53116306
11Abnormal mitochondria in muscle tissue (HP:0008316)3.48679414
12Mitochondrial inheritance (HP:0001427)3.41628924
13Hyperammonemia (HP:0001987)3.41032780
14Hepatocellular necrosis (HP:0001404)3.38536444
15Abnormality of fatty-acid metabolism (HP:0004359)3.32168322
16Deep venous thrombosis (HP:0002625)3.29901753
17Hyperglycinuria (HP:0003108)3.23870482
18Abnormality of dicarboxylic acid metabolism (HP:0010995)3.16098783
19Dicarboxylic aciduria (HP:0003215)3.16098783
20Lethargy (HP:0001254)3.08576925
21Abnormality of glutamine family amino acid metabolism (HP:0010902)3.07128177
22Increased CSF lactate (HP:0002490)3.06535616
23Vertebral compression fractures (HP:0002953)3.04232134
24Increased muscle lipid content (HP:0009058)3.01261999
25Hyperlipoproteinemia (HP:0010980)2.97831501
26Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.92670793
27Hypoglycemic coma (HP:0001325)2.92284410
28Ragged-red muscle fibers (HP:0003200)2.91884112
29Lipid accumulation in hepatocytes (HP:0006561)2.90469746
30Decreased activity of mitochondrial respiratory chain (HP:0008972)2.88553837
31Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.88553837
32Hyperglycinemia (HP:0002154)2.85838647
33Prolonged partial thromboplastin time (HP:0003645)2.84385329
34Abnormality of glycine metabolism (HP:0010895)2.83261408
35Abnormality of serine family amino acid metabolism (HP:0010894)2.83261408
36Ketosis (HP:0001946)2.82869161
37Progressive macrocephaly (HP:0004481)2.81793016
38Achilles tendon contracture (HP:0001771)2.80568500
39Increased intramyocellular lipid droplets (HP:0012240)2.79243248
40Aplasia/Hypoplasia of the sacrum (HP:0008517)2.78457512
41Generalized aminoaciduria (HP:0002909)2.78373695
42Hypolipoproteinemia (HP:0010981)2.76309833
43Abnormality of cells of the erythroid lineage (HP:0012130)2.74720610
44Lactic acidosis (HP:0003128)2.74456134
45Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.71364320
46Abnormality of urine glucose concentration (HP:0011016)2.70425969
47Glycosuria (HP:0003076)2.70425969
48Gout (HP:0001997)2.69815207
49Multiple enchondromatosis (HP:0005701)2.68269571
50Nausea (HP:0002018)2.67062272
51Malnutrition (HP:0004395)2.66842115
52Fat malabsorption (HP:0002630)2.61869816
53Abnormality of the Achilles tendon (HP:0005109)2.60561590
54Abnormality of glycolipid metabolism (HP:0010969)2.58193602
55Abnormality of liposaccharide metabolism (HP:0010968)2.58193602
56Abnormality of glycosphingolipid metabolism (HP:0004343)2.58193602
57Microretrognathia (HP:0000308)2.56269667
58Increased hepatocellular lipid droplets (HP:0006565)2.55156997
59Vomiting (HP:0002013)2.50797123
60Myokymia (HP:0002411)2.49917468
61Rough bone trabeculation (HP:0100670)2.49245136
62Abnormality of aspartate family amino acid metabolism (HP:0010899)2.47762248
63Emotional lability (HP:0000712)2.47504513
64Abnormal number of erythroid precursors (HP:0012131)2.44692825
65Pallor (HP:0000980)2.44173409
66Rhabdomyolysis (HP:0003201)2.43328356
67Abnormality of purine metabolism (HP:0004352)2.42568481
68Distal lower limb muscle weakness (HP:0009053)2.42362737
69Respiratory failure (HP:0002878)2.41738794
70Abnormality of sulfur amino acid metabolism (HP:0004339)2.41221606
71Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.40768849
72Hyperphosphaturia (HP:0003109)2.40760442
73Metabolic acidosis (HP:0001942)2.39199859
74Increased serum lactate (HP:0002151)2.38585356
75Ketoacidosis (HP:0001993)2.37310011
76Myopathic facies (HP:0002058)2.34140127
77Hyperparathyroidism (HP:0000843)2.33359393
78Testicular atrophy (HP:0000029)2.33349272
79Abnormality of nucleobase metabolism (HP:0010932)2.32803767
80Abnormal cartilage morphology (HP:0002763)2.32555992
81Ileus (HP:0002595)2.32090228
82Hyperbilirubinemia (HP:0002904)2.31948122
83Renal Fanconi syndrome (HP:0001994)2.31391001
84Proximal tubulopathy (HP:0000114)2.30659175
85Late onset (HP:0003584)2.28495149
86Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.27245814
87Respiratory difficulties (HP:0002880)2.25707152
88Hypoalphalipoproteinemia (HP:0003233)2.25432822
89Polycythemia (HP:0001901)2.25086692
90Increased serum pyruvate (HP:0003542)2.24951722
91Abnormality of glycolysis (HP:0004366)2.24951722
92Cholecystitis (HP:0001082)2.24417768
93Abnormal gallbladder physiology (HP:0012438)2.24417768
94Myoglobinuria (HP:0002913)2.22423173
95Delayed CNS myelination (HP:0002188)2.19832171
96Prolonged neonatal jaundice (HP:0006579)2.19531573
97CNS demyelination (HP:0007305)2.19070581
98Bulbar palsy (HP:0001283)2.18147597
99Complement deficiency (HP:0004431)2.17393636
100Spastic paraparesis (HP:0002313)2.14923219
101Microvesicular hepatic steatosis (HP:0001414)2.14217113
102Abnormality of pyrimidine metabolism (HP:0004353)2.13274339
103Systemic lupus erythematosus (HP:0002725)2.13044210
104Steatorrhea (HP:0002570)2.12126078
105Trismus (HP:0000211)2.11151487
106Hypertensive crisis (HP:0100735)2.11028731
107Redundant skin (HP:0001582)2.10799660
108Hypokinesia (HP:0002375)2.09973670
109Exercise intolerance (HP:0003546)2.09327258
110Macrocytic anemia (HP:0001972)2.08604538
111Progressive muscle weakness (HP:0003323)2.08466217
112Vacuolated lymphocytes (HP:0001922)2.07192528
1133-Methylglutaconic aciduria (HP:0003535)2.07079730
114Hyperthyroidism (HP:0000836)2.06348174
115Axonal loss (HP:0003447)2.06287622
116Cholelithiasis (HP:0001081)2.05355103
117Abnormality of complement system (HP:0005339)2.05164199
118Abnormality of methionine metabolism (HP:0010901)2.04060523
119Exertional dyspnea (HP:0002875)2.02990734
120Abnormality of serum amino acid levels (HP:0003112)2.02799069
121Cerebral palsy (HP:0100021)2.01512507
122Opisthotonus (HP:0002179)2.00820865
123Leukodystrophy (HP:0002415)2.00079892
124Broad distal phalanx of finger (HP:0009836)1.99674836
125Abnormality of the common coagulation pathway (HP:0010990)1.98560411
126Increased serum ferritin (HP:0003281)1.98155610
127Abnormal trabecular bone morphology (HP:0100671)1.97523431
128Palpitations (HP:0001962)1.96697420
129Abnormal gallbladder morphology (HP:0012437)1.95275192
130Pancreatitis (HP:0001733)1.93293252
131Abnormality of reticulocytes (HP:0004312)1.91427862
132Abnormal hemoglobin (HP:0011902)1.90407233
133Right ventricular cardiomyopathy (HP:0011663)1.89864974
134Methylmalonic aciduria (HP:0012120)1.89020220
135Increased cerebral lipofuscin (HP:0011813)1.88962086
136Growth hormone excess (HP:0000845)1.88256035
137Premature skin wrinkling (HP:0100678)1.86897959
138Centrally nucleated skeletal muscle fibers (HP:0003687)1.84926511
139Increased neuronal autofluorescent lipopigment (HP:0002074)1.82950818
140Cerebral hypomyelination (HP:0006808)1.82266498
141Purpura (HP:0000979)1.79531278
142Type I transferrin isoform profile (HP:0003642)1.77689768
143Congenital ichthyosiform erythroderma (HP:0007431)1.75973311
144Distal upper limb amyotrophy (HP:0007149)1.73096715
145Upper limb amyotrophy (HP:0009129)1.73096715
146Polygenic inheritance (HP:0010982)1.72827485
147Abnormality of the nasal mucosa (HP:0000433)1.72555454
148Stridor (HP:0010307)1.70962286
149Abnormal urine phosphate concentration (HP:0012599)1.70901835
150Optic disc pallor (HP:0000543)1.69170496
151Truncus arteriosus (HP:0001660)1.67399679
152Chronic obstructive pulmonary disease (HP:0006510)1.67088692
153Obstructive lung disease (HP:0006536)1.67088692

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.74984244
2BCKDK4.52279615
3NME24.49677295
4SMG13.53610369
5ERN13.32007219
6PIM23.07021426
7TBK12.82221504
8ARAF2.78884908
9MAP3K112.70979274
10KDR2.63593147
11TESK12.36556300
12MST1R2.34784677
13TESK22.19338753
14NME12.16152924
15TRIB32.10157365
16BUB12.06075572
17MAP2K21.97997624
18MYLK1.79615948
19EIF2AK11.75598805
20LRRK21.53620182
21GRK61.49514871
22ABL21.46720869
23LIMK11.41940157
24MST41.39759678
25IKBKE1.39121097
26MAP3K31.37681031
27PIK3CA1.36149644
28PRKD31.30724324
29DAPK31.30320283
30DAPK11.29635463
31PKN21.29599056
32FGFR41.28416506
33ILK1.27915260
34BRAF1.27536752
35TAOK11.21666326
36TYK21.21331543
37MAP2K31.20998399
38BLK1.20962041
39EPHA21.20240888
40MAP4K11.19761558
41TLK11.15442451
42EPHB21.15074439
43LMTK21.14805316
44ZAP701.13932969
45PRPF4B1.11653445
46TAF11.09667705
47PBK1.09086589
48KSR21.03952910
49STK160.94969659
50MAPKAPK30.91654274
51PAK40.91257523
52IRAK30.90377082
53IKBKB0.89955203
54ICK0.89257252
55MAP3K120.85925496
56MAP2K10.85792353
57TAOK20.83609640
58MAP3K80.81577057
59MAP3K140.78875648
60GRK50.78669427
61BRSK10.78160614
62PRKG20.76372456
63RPS6KA40.74513550
64NEK10.73552174
65MAP3K100.70186849
66SCYL20.69755952
67WNK40.69496058
68SIK10.69002819
69CDK11A0.67388123
70MAP2K60.66984283
71CDK190.66503546
72PDK20.64891356
73MAP3K10.64311042
74MAPK110.64222806
75EEF2K0.61722317
76RIPK10.60267691
77CAMK2G0.59408655
78PAK10.58129210
79CDK140.58019261
80CDK150.57846703
81TTN0.57622238
82PDK30.57509199
83PDK40.57509199
84AKT20.57078440
85NEK90.57014011
86RPS6KB20.56565603
87PIM10.56245064
88MAP3K20.55633634
89TAOK30.55531498
90CDC70.55460346
91WEE10.55151442
92CDK70.53843476
93CAMKK10.53721916
94AURKA0.52943408
95VRK10.52321001
96MAPKAPK50.52227752
97PIK3CG0.50875364
98PDPK10.50726919
99CSNK1G30.50606733
100CDK180.49831597
101CSNK2A20.49733013
102MUSK0.48606429
103OBSCN0.47442139
104MET0.45651488
105DYRK1B0.44891251
106PRKCI0.44381138
107PTK60.42126050
108AURKB0.40996094
109EIF2AK30.40517297
110MAP3K50.40380900
111MAPK120.39514475
112SIK20.39299562
113PINK10.39055588
114MAPK40.38385779
115PTK20.37469969
116PRKCD0.37289748
117RPS6KA20.36950778
118PRKD20.36700162
119DYRK30.34240588
120JAK20.34011953
121CSNK2A10.33993278
122NLK0.31709469
123MAPKAPK20.31445460
124DYRK20.30852049
125RPS6KA50.30469371
126CAMK2D0.28646295
127CAMK2B0.27616452
128RPS6KL10.27490256
129RPS6KC10.27490256
130RPS6KA10.27147122
131SRPK10.27031785
132EPHB10.25929047
133PRKCZ0.25922239
134TGFBR10.25637845

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001902.94309743
2Ribosome_Homo sapiens_hsa030102.67494837
3Parkinsons disease_Homo sapiens_hsa050122.64500622
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.62886894
5Proteasome_Homo sapiens_hsa030502.56441719
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.52962689
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.52346548
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.32789110
9Sulfur relay system_Homo sapiens_hsa041222.21756399
10Folate biosynthesis_Homo sapiens_hsa007902.19143579
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.12820704
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.04311855
13Fatty acid degradation_Homo sapiens_hsa000712.01539293
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.00824767
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.97981397
16Sulfur metabolism_Homo sapiens_hsa009201.94401910
17Tryptophan metabolism_Homo sapiens_hsa003801.91319866
18Arginine biosynthesis_Homo sapiens_hsa002201.83974819
19Pentose and glucuronate interconversions_Homo sapiens_hsa000401.81518742
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.78275065
21Propanoate metabolism_Homo sapiens_hsa006401.76794545
22Alzheimers disease_Homo sapiens_hsa050101.74453078
23Carbon metabolism_Homo sapiens_hsa012001.70347252
24Fat digestion and absorption_Homo sapiens_hsa049751.68007635
25Base excision repair_Homo sapiens_hsa034101.67005450
26Peroxisome_Homo sapiens_hsa041461.64944929
27Huntingtons disease_Homo sapiens_hsa050161.61274319
28Pyruvate metabolism_Homo sapiens_hsa006201.60936781
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.60364795
30Other glycan degradation_Homo sapiens_hsa005111.58113581
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.55590611
32Butanoate metabolism_Homo sapiens_hsa006501.53246321
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.50842597
34Vibrio cholerae infection_Homo sapiens_hsa051101.45284031
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.44910109
36Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.44492285
37Chemical carcinogenesis_Homo sapiens_hsa052041.44201439
38Phenylalanine metabolism_Homo sapiens_hsa003601.43168268
39Caffeine metabolism_Homo sapiens_hsa002321.42058818
40Histidine metabolism_Homo sapiens_hsa003401.41928346
41Pentose phosphate pathway_Homo sapiens_hsa000301.41718181
42Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.40071524
43Biosynthesis of amino acids_Homo sapiens_hsa012301.37903969
44Glutathione metabolism_Homo sapiens_hsa004801.37019658
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.35089397
46PPAR signaling pathway_Homo sapiens_hsa033201.33303571
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.31340289
48Nitrogen metabolism_Homo sapiens_hsa009101.30054314
49Cyanoamino acid metabolism_Homo sapiens_hsa004601.27033979
50Complement and coagulation cascades_Homo sapiens_hsa046101.25807858
51beta-Alanine metabolism_Homo sapiens_hsa004101.23145988
52Fatty acid metabolism_Homo sapiens_hsa012121.22188945
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.19264362
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.19132317
55Spliceosome_Homo sapiens_hsa030401.14827421
56Tyrosine metabolism_Homo sapiens_hsa003501.09273894
57Arginine and proline metabolism_Homo sapiens_hsa003301.09267248
58Galactose metabolism_Homo sapiens_hsa000521.06793954
59Fructose and mannose metabolism_Homo sapiens_hsa000511.06311216
60Starch and sucrose metabolism_Homo sapiens_hsa005001.05995756
61Bile secretion_Homo sapiens_hsa049761.05203832
62Cardiac muscle contraction_Homo sapiens_hsa042601.04451912
63Synaptic vesicle cycle_Homo sapiens_hsa047211.04433687
64Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.04377276
65Fatty acid elongation_Homo sapiens_hsa000621.02366404
66Steroid hormone biosynthesis_Homo sapiens_hsa001400.99820999
67Selenocompound metabolism_Homo sapiens_hsa004500.98215657
68Mismatch repair_Homo sapiens_hsa034300.98203255
69Protein export_Homo sapiens_hsa030600.92168119
70Steroid biosynthesis_Homo sapiens_hsa001000.91446784
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88924665
72Pyrimidine metabolism_Homo sapiens_hsa002400.87042526
73Collecting duct acid secretion_Homo sapiens_hsa049660.85778450
74Retinol metabolism_Homo sapiens_hsa008300.85032839
75Lysosome_Homo sapiens_hsa041420.82780637
76Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.82663873
77Staphylococcus aureus infection_Homo sapiens_hsa051500.81608116
78Metabolic pathways_Homo sapiens_hsa011000.81092171
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78232419
80RNA polymerase_Homo sapiens_hsa030200.75156739
81Vitamin digestion and absorption_Homo sapiens_hsa049770.70030188
82N-Glycan biosynthesis_Homo sapiens_hsa005100.68766404
83Glycosaminoglycan degradation_Homo sapiens_hsa005310.67440495
84Maturity onset diabetes of the young_Homo sapiens_hsa049500.64539031
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64468530
86Nucleotide excision repair_Homo sapiens_hsa034200.64006333
87One carbon pool by folate_Homo sapiens_hsa006700.62181380
88Glycerolipid metabolism_Homo sapiens_hsa005610.60908447
89Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.57212914
90Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.56894420
91Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.56168026
92Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.54687104
93Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.53546499
94Mineral absorption_Homo sapiens_hsa049780.52840886
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44353626
96Salmonella infection_Homo sapiens_hsa051320.43388319
97Legionellosis_Homo sapiens_hsa051340.37564451
98Epstein-Barr virus infection_Homo sapiens_hsa051690.36451255
99ABC transporters_Homo sapiens_hsa020100.35091491
100Homologous recombination_Homo sapiens_hsa034400.30906001
101Shigellosis_Homo sapiens_hsa051310.29382448
102Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.26461718
103Renin-angiotensin system_Homo sapiens_hsa046140.26457763
104Rheumatoid arthritis_Homo sapiens_hsa053230.26315597
105Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.24016096
106Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.22808698
107Vitamin B6 metabolism_Homo sapiens_hsa007500.20895689
108Regulation of autophagy_Homo sapiens_hsa041400.20617933
109Arachidonic acid metabolism_Homo sapiens_hsa005900.19958699
110Pertussis_Homo sapiens_hsa051330.19651524
111Phagosome_Homo sapiens_hsa041450.18015551
112Primary immunodeficiency_Homo sapiens_hsa053400.17787161
113Linoleic acid metabolism_Homo sapiens_hsa005910.16734775
114Prion diseases_Homo sapiens_hsa050200.16560847
115Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.16554979
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.14836012
117DNA replication_Homo sapiens_hsa030300.14332645
118Autoimmune thyroid disease_Homo sapiens_hsa053200.14154493
119Bladder cancer_Homo sapiens_hsa052190.13870284
120Apoptosis_Homo sapiens_hsa042100.13859843
121RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.12563740
122Purine metabolism_Homo sapiens_hsa002300.12173182
123alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.11743318
124Adipocytokine signaling pathway_Homo sapiens_hsa049200.10549441
125Asthma_Homo sapiens_hsa053100.09884066
126Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.08923020
127Intestinal immune network for IgA production_Homo sapiens_hsa046720.07264302

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