EDIL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an integrin ligand. It plays an important role in mediating angiogenesis and may be important in vessel wall remodeling and development. It also influences endothelial cell behavior. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)7.62412016
2axon ensheathment in central nervous system (GO:0032291)7.62412016
3synaptic vesicle docking involved in exocytosis (GO:0016081)5.27752126
4neuron cell-cell adhesion (GO:0007158)4.74481114
5fatty acid elongation (GO:0030497)4.72479608
6long-chain fatty acid biosynthetic process (GO:0042759)4.57094219
7presynaptic membrane organization (GO:0097090)4.40106144
8presynaptic membrane assembly (GO:0097105)4.23788512
9negative regulation of neurotransmitter transport (GO:0051589)4.14938519
10myelination (GO:0042552)4.10245531
11axon ensheathment (GO:0008366)4.08852122
12ensheathment of neurons (GO:0007272)4.08852122
13neuronal action potential propagation (GO:0019227)4.04200107
14establishment of mitochondrion localization (GO:0051654)3.99993049
15synaptic vesicle maturation (GO:0016188)3.87811992
16regulation of short-term neuronal synaptic plasticity (GO:0048172)3.85809465
17negative regulation of neurotransmitter secretion (GO:0046929)3.82625458
18synaptic vesicle exocytosis (GO:0016079)3.79758248
19vocalization behavior (GO:0071625)3.74515919
20L-amino acid import (GO:0043092)3.69009405
21regulation of synaptic vesicle exocytosis (GO:2000300)3.61709135
22positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.60347406
23ionotropic glutamate receptor signaling pathway (GO:0035235)3.58596021
24regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.57315094
25neuron recognition (GO:0008038)3.56211705
26protein localization to synapse (GO:0035418)3.54907914
27glutamate secretion (GO:0014047)3.51273698
28negative regulation of synaptic transmission, GABAergic (GO:0032229)3.50219772
29adult walking behavior (GO:0007628)3.49757916
30gamma-aminobutyric acid signaling pathway (GO:0007214)3.37638515
31positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.35514038
32negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.34869044
33glutamate receptor signaling pathway (GO:0007215)3.29578808
34negative regulation of protein localization to cell surface (GO:2000009)3.27774132
35response to gravity (GO:0009629)3.23748609
36response to methylmercury (GO:0051597)3.23146728
37peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.22526110
38myelin maintenance (GO:0043217)3.20439174
39collagen fibril organization (GO:0030199)3.20386049
40transmission of nerve impulse (GO:0019226)3.19468197
41neuron-neuron synaptic transmission (GO:0007270)3.16992428
42neurotransmitter uptake (GO:0001504)3.14441818
43regulation of collateral sprouting (GO:0048670)3.13540853
44regulation of glutamate receptor signaling pathway (GO:1900449)3.09485205
45synaptic transmission, glutamatergic (GO:0035249)3.08585337
46axonal fasciculation (GO:0007413)3.07883790
47apical protein localization (GO:0045176)3.07625924
48sequestering of extracellular ligand from receptor (GO:0035581)3.06912647
49cerebellar granule cell differentiation (GO:0021707)3.06049149
50positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.05793114
51regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.05145498
52regulation of synaptic vesicle transport (GO:1902803)3.03862523
53startle response (GO:0001964)3.03846930
54sodium ion export (GO:0071436)3.01384841
55cell adhesion mediated by integrin (GO:0033627)3.00843956
56regulation of neuronal synaptic plasticity (GO:0048168)3.00594023
57actin filament depolymerization (GO:0030042)2.99811523
58glycerophospholipid catabolic process (GO:0046475)2.97776358
59membrane assembly (GO:0071709)2.97493140
60cerebral cortex radially oriented cell migration (GO:0021799)2.97490127
61locomotory exploration behavior (GO:0035641)2.97184238
62eye photoreceptor cell differentiation (GO:0001754)2.94555210
63photoreceptor cell differentiation (GO:0046530)2.94555210
64postsynaptic membrane organization (GO:0001941)2.93152606
65detection of calcium ion (GO:0005513)2.91126376
66regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.90827358
67chondrocyte proliferation (GO:0035988)2.90816069
68neuron remodeling (GO:0016322)2.90292449
69glycine transport (GO:0015816)2.89346087
70cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.89071611
71oligodendrocyte differentiation (GO:0048709)2.88910461
72regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.87916141
73potassium ion homeostasis (GO:0055075)2.87899034
74dendritic spine morphogenesis (GO:0060997)2.86638784
75membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.86405415
76cellular potassium ion homeostasis (GO:0030007)2.85398538
77neurotransmitter-gated ion channel clustering (GO:0072578)2.84728914
78membrane hyperpolarization (GO:0060081)2.84300320
79regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.83950451
80negative regulation of axonogenesis (GO:0050771)2.82613253
81cell communication by electrical coupling (GO:0010644)2.82406043
82gamma-aminobutyric acid transport (GO:0015812)2.82039984
83amino acid import (GO:0043090)2.80811144
84neurotransmitter secretion (GO:0007269)2.79326809
85dendrite morphogenesis (GO:0048813)2.79123782
86detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.78969146
87detection of temperature stimulus involved in sensory perception (GO:0050961)2.78969146
88regulation of voltage-gated calcium channel activity (GO:1901385)2.76719058
89regulation of synaptic transmission, glutamatergic (GO:0051966)2.76667153
90neuromuscular process controlling posture (GO:0050884)2.76481962
91neurotransmitter transport (GO:0006836)2.73918326
92positive regulation of synapse assembly (GO:0051965)2.73472340
93asymmetric protein localization (GO:0008105)2.72894559
94regulation of excitatory postsynaptic membrane potential (GO:0060079)2.72647303
95nerve growth factor signaling pathway (GO:0038180)2.70667541
96synapse assembly (GO:0007416)2.66107986
97G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.65981158
98negative regulation of hormone biosynthetic process (GO:0032353)2.65343534
99long-term synaptic potentiation (GO:0060291)2.64963888
100neuronal ion channel clustering (GO:0045161)2.63336032
101regulation of postsynaptic membrane potential (GO:0060078)2.63297277
102negative regulation of synaptic transmission (GO:0050805)2.63064664
103import into cell (GO:0098657)2.62184095
104regulation of long-term neuronal synaptic plasticity (GO:0048169)2.61703922
105mating behavior (GO:0007617)2.61528497
106adult locomotory behavior (GO:0008344)2.61274593
107mechanosensory behavior (GO:0007638)2.61044938
108regulation of respiratory system process (GO:0044065)2.60566085
109positive regulation of potassium ion transport (GO:0043268)2.60515930
110astrocyte development (GO:0014002)2.59839879
111limb bud formation (GO:0060174)2.59360370
112layer formation in cerebral cortex (GO:0021819)2.56918173
113long-term memory (GO:0007616)2.56454558
114regulation of synaptic transmission, GABAergic (GO:0032228)2.55630233
115regulation of neurotransmitter secretion (GO:0046928)2.54268084
116negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.53951211
117endodermal cell differentiation (GO:0035987)2.52109756
118positive regulation of fibroblast migration (GO:0010763)2.49046337
119cytoskeletal anchoring at plasma membrane (GO:0007016)2.46284684
120positive regulation of actin filament depolymerization (GO:0030836)2.46172084
121kidney mesenchyme development (GO:0072074)2.45871809
122negative regulation of dendrite morphogenesis (GO:0050774)2.45581832
123proline transport (GO:0015824)2.44065998
124positive regulation of neurotransmitter transport (GO:0051590)2.37655759
125metanephric mesenchyme development (GO:0072075)2.35874788
126mesenchymal-epithelial cell signaling (GO:0060638)2.33689153
127exploration behavior (GO:0035640)2.33316975
128protein retention in ER lumen (GO:0006621)2.32927615
129regulation of neurotransmitter transport (GO:0051588)2.30401747
130regulation of synaptic plasticity (GO:0048167)2.29291059
131positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.28814918
132regulation of synapse assembly (GO:0051963)2.27691068
133negative regulation of hormone metabolic process (GO:0032351)2.27030125
134regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.26600669
135regulation of dendritic spine development (GO:0060998)2.26090255
136smooth muscle tissue development (GO:0048745)2.25244407
137positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.24983031
138urinary tract smooth muscle contraction (GO:0014848)2.23475982
139cerebellar Purkinje cell layer development (GO:0021680)2.23404111
140regulation of Rac protein signal transduction (GO:0035020)2.23085068
141auditory behavior (GO:0031223)2.22838782
142protein localization to cell surface (GO:0034394)2.21460513
143positive regulation of synapse maturation (GO:0090129)2.19889205
144cell communication involved in cardiac conduction (GO:0086065)2.19088308
145extracellular matrix assembly (GO:0085029)2.18728795
146negative regulation of cytosolic calcium ion concentration (GO:0051481)2.18178735
147suckling behavior (GO:0001967)2.18157496
148regulation of neurotransmitter uptake (GO:0051580)2.17587799
149clathrin coat assembly (GO:0048268)2.17553993
150regulation of cell communication by electrical coupling (GO:0010649)2.17083029

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.33173827
2GBX2_23144817_ChIP-Seq_PC3_Human3.88989118
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.85378031
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.88726247
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.77766214
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.76520392
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.39969612
8TAF15_26573619_Chip-Seq_HEK293_Human2.39793629
9* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.39663561
10* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.39663561
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.36262889
12* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.35528386
13* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.33904114
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.33150269
15PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.30418063
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.29427832
17* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.27666488
18AR_21572438_ChIP-Seq_LNCaP_Human2.24965095
19* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.24265743
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.14929840
21* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.10240599
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.05403453
23SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.05396517
24EZH2_27294783_Chip-Seq_ESCs_Mouse2.04177619
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.00617580
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.96942342
27EP300_21415370_ChIP-Seq_HL-1_Mouse1.95170653
28* REST_21632747_ChIP-Seq_MESCs_Mouse1.91161787
29DROSHA_22980978_ChIP-Seq_HELA_Human1.84777613
30* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.82550427
31OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.82479548
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.79994591
33* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.74509569
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71977006
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.65997564
36WT1_19549856_ChIP-ChIP_CCG9911_Human1.65522749
37BMI1_23680149_ChIP-Seq_NPCS_Mouse1.65325048
38RARB_27405468_Chip-Seq_BRAIN_Mouse1.64783964
39VDR_22108803_ChIP-Seq_LS180_Human1.64563657
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.62244829
41* P300_19829295_ChIP-Seq_ESCs_Human1.58948087
42SMAD3_21741376_ChIP-Seq_EPCs_Human1.58255196
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.57102277
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.56299584
45* SMAD4_21799915_ChIP-Seq_A2780_Human1.55624467
46REST_18959480_ChIP-ChIP_MESCs_Mouse1.54419608
47* CJUN_26792858_Chip-Seq_BT549_Human1.51829268
48* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.51715399
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.51670518
50* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.50790018
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50121311
52ER_23166858_ChIP-Seq_MCF-7_Human1.49585674
53NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.45303832
54VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.45014824
55CDX2_19796622_ChIP-Seq_MESCs_Mouse1.42157728
56IGF1R_20145208_ChIP-Seq_DFB_Human1.39702764
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39342886
58BRD4_25478319_ChIP-Seq_HGPS_Human1.35538062
59* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.33987735
60TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33309384
61CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.33029213
62CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.32236714
63* RNF2_27304074_Chip-Seq_NSC_Mouse1.31986645
64CTNNB1_20460455_ChIP-Seq_HCT116_Human1.29836069
65* STAT3_23295773_ChIP-Seq_U87_Human1.26868447
66TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26458000
67YAP1_20516196_ChIP-Seq_MESCs_Mouse1.25033516
68FUS_26573619_Chip-Seq_HEK293_Human1.23321698
69AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21454349
70TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.20944734
71AR_25329375_ChIP-Seq_VCAP_Human1.20060467
72UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19720083
73P53_22127205_ChIP-Seq_FIBROBLAST_Human1.16785800
74SMAD_19615063_ChIP-ChIP_OVARY_Human1.16713206
75* SOX2_21211035_ChIP-Seq_LN229_Gbm1.16190409
76TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16009440
77FLI1_27457419_Chip-Seq_LIVER_Mouse1.16006236
78HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.14802182
79TCF4_23295773_ChIP-Seq_U87_Human1.13009441
80NANOG_18555785_Chip-Seq_ESCs_Mouse1.12814999
81TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12647051
82TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.12087951
83NR3C1_23031785_ChIP-Seq_PC12_Mouse1.11796695
84* PRDM14_20953172_ChIP-Seq_ESCs_Human1.10095715
85* ARNT_22903824_ChIP-Seq_MCF-7_Human1.09320973
86* RING1B_27294783_Chip-Seq_ESCs_Mouse1.08012214
87WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06849827
88MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.06408183
89SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.06257599
90SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.06199106
91RING1B_27294783_Chip-Seq_NPCs_Mouse1.03887692
92RUNX2_22187159_ChIP-Seq_PCA_Human1.03470646
93NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03376262
94PCGF2_27294783_Chip-Seq_ESCs_Mouse1.03260959
95* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.02843065
96* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.02137303
97ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01868286
98* AHR_22903824_ChIP-Seq_MCF-7_Human1.01711260
99NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.01365671
100NRF2_20460467_ChIP-Seq_MEFs_Mouse1.01365671
101* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.01044091
102CMYC_18555785_Chip-Seq_ESCs_Mouse1.00972301
103SMAD3_21741376_ChIP-Seq_HESCs_Human1.00734832
104WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99205254
105* SOX9_26525672_Chip-Seq_HEART_Mouse0.99157366
106MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98304390
107IKZF1_21737484_ChIP-ChIP_HCT116_Human0.98284164
108EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95889473
109JUN_21703547_ChIP-Seq_K562_Human0.95679551
110ZNF274_21170338_ChIP-Seq_K562_Hela0.95502668
111TP53_18474530_ChIP-ChIP_U2OS_Human0.95121623
112SUZ12_18555785_Chip-Seq_ESCs_Mouse0.94994468
113MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94598568
114E2F1_18555785_Chip-Seq_ESCs_Mouse0.94379319
115* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93512509
116KDM2B_26808549_Chip-Seq_REH_Human0.92730065
117* TAL1_26923725_Chip-Seq_HPCs_Mouse0.92400709
118TP53_16413492_ChIP-PET_HCT116_Human0.92152193
119ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.91735781
120P53_22387025_ChIP-Seq_ESCs_Mouse0.89995221
121P300_18555785_Chip-Seq_ESCs_Mouse0.89400607
122AR_19668381_ChIP-Seq_PC3_Human0.88477299

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.17074475
2MP0003880_abnormal_central_pattern5.16456043
3MP0004859_abnormal_synaptic_plasticity4.01291316
4MP0004270_analgesia3.67848179
5MP0000920_abnormal_myelination3.16675315
6MP0003635_abnormal_synaptic_transmissio3.08620685
7MP0002064_seizures2.91417331
8MP0005423_abnormal_somatic_nervous2.88998327
9MP0002272_abnormal_nervous_system2.82517923
10MP0009046_muscle_twitch2.73762401
11MP0001486_abnormal_startle_reflex2.73387199
12MP0009745_abnormal_behavioral_response2.72222957
13MP0005275_abnormal_skin_tensile2.70098986
14MP0002734_abnormal_mechanical_nocicepti2.52214395
15MP0001968_abnormal_touch/_nociception2.51691936
16MP0002063_abnormal_learning/memory/cond2.47723308
17MP0002735_abnormal_chemical_nociception2.33225412
18MP0003329_amyloid_beta_deposits2.29936764
19MP0003950_abnormal_plasma_membrane2.27510676
20MP0002572_abnormal_emotion/affect_behav2.24434661
21MP0001958_emphysema2.23802243
22MP0005503_abnormal_tendon_morphology2.21717327
23MP0000778_abnormal_nervous_system2.14247561
24MP0004272_abnormal_basement_membrane2.09334849
25MP0002736_abnormal_nociception_after2.04851376
26MP0004142_abnormal_muscle_tone2.04718303
27MP0004885_abnormal_endolymph2.04547619
28MP0003279_aneurysm2.04052408
29MP0001529_abnormal_vocalization2.01364363
30MP0004742_abnormal_vestibular_system1.98827935
31MP0001970_abnormal_pain_threshold1.93124351
32MP0010386_abnormal_urinary_bladder1.91647529
33MP0000013_abnormal_adipose_tissue1.91314263
34MP0002067_abnormal_sensory_capabilities1.90963791
35MP0005171_absent_coat_pigmentation1.83625223
36MP0003690_abnormal_glial_cell1.81744005
37MP0002733_abnormal_thermal_nociception1.79030724
38MP0003705_abnormal_hypodermis_morpholog1.78996454
39MP0006276_abnormal_autonomic_nervous1.78859130
40MP0001905_abnormal_dopamine_level1.75807201
41MP0003283_abnormal_digestive_organ1.74874218
42MP0001440_abnormal_grooming_behavior1.71415688
43MP0003634_abnormal_glial_cell1.68305915
44MP0003566_abnormal_cell_adhesion1.67283069
45MP0008569_lethality_at_weaning1.67164152
46MP0000955_abnormal_spinal_cord1.66234652
47MP0002184_abnormal_innervation1.61091430
48MP0005551_abnormal_eye_electrophysiolog1.56636850
49MP0001501_abnormal_sleep_pattern1.53976504
50MP0002882_abnormal_neuron_morphology1.53747567
51MP0002229_neurodegeneration1.53487670
52MP0002822_catalepsy1.49653954
53MP0005386_behavior/neurological_phenoty1.44560787
54MP0004924_abnormal_behavior1.44560787
55MP0003633_abnormal_nervous_system1.42970274
56MP0002066_abnormal_motor_capabilities/c1.41103472
57MP0005646_abnormal_pituitary_gland1.36814361
58MP0003631_nervous_system_phenotype1.35345358
59MP0005257_abnormal_intraocular_pressure1.34208317
60MP0001485_abnormal_pinna_reflex1.33628318
61MP0002557_abnormal_social/conspecific_i1.32412306
62MP0010368_abnormal_lymphatic_system1.32135100
63MP0005409_darkened_coat_color1.31866349
64MP0002295_abnormal_pulmonary_circulatio1.28122831
65MP0009780_abnormal_chondrocyte_physiolo1.25808603
66MP0003632_abnormal_nervous_system1.25552946
67MP0004811_abnormal_neuron_physiology1.24594901
68MP0001502_abnormal_circadian_rhythm1.24079560
69MP0003136_yellow_coat_color1.22682039
70MP0005645_abnormal_hypothalamus_physiol1.21893671
71MP0001963_abnormal_hearing_physiology1.20423969
72MP0006054_spinal_hemorrhage1.19755391
73MP0004043_abnormal_pH_regulation1.18160962
74MP0001299_abnormal_eye_distance/1.16684620
75MP0000569_abnormal_digit_pigmentation1.15501994
76MP0004858_abnormal_nervous_system1.15331797
77MP0002752_abnormal_somatic_nervous1.14944050
78MP0009384_cardiac_valve_regurgitation1.14155416
79MP0000534_abnormal_ureter_morphology1.13379398
80MP0005187_abnormal_penis_morphology1.11999771
81MP0001984_abnormal_olfaction1.11911041
82MP0010352_gastrointestinal_tract_polyps1.11514548
83MP0001188_hyperpigmentation1.11388186
84MP0004134_abnormal_chest_morphology1.11147532
85MP0001542_abnormal_bone_strength1.07915578
86MP0005410_abnormal_fertilization1.07079085
87MP0001177_atelectasis1.06846237
88MP0003122_maternal_imprinting1.06787720
89MP0000604_amyloidosis1.02124562
90MP0005508_abnormal_skeleton_morphology1.01842171
91MP0005623_abnormal_meninges_morphology0.99099913
92MP0002152_abnormal_brain_morphology0.98178294
93MP0004145_abnormal_muscle_electrophysio0.97795309
94MP0002896_abnormal_bone_mineralization0.97163284
95MP0003091_abnormal_cell_migration0.95768590
96MP0000003_abnormal_adipose_tissue0.93484675
97MP0008260_abnormal_autophagy0.90597613
98MP0005595_abnormal_vascular_smooth0.88614657
99MP0002909_abnormal_adrenal_gland0.87380125
100MP0003385_abnormal_body_wall0.85312004
101MP0005023_abnormal_wound_healing0.83953064
102MP0000767_abnormal_smooth_muscle0.81073772
103MP0000749_muscle_degeneration0.80355000
104MP0003868_abnormal_feces_composition0.80211295
105MP0000631_abnormal_neuroendocrine_gland0.79662783
106MP0003787_abnormal_imprinting0.78577077
107MP0000026_abnormal_inner_ear0.76651245
108MP0001986_abnormal_taste_sensitivity0.76466668
109MP0010030_abnormal_orbit_morphology0.76114888
110MP0009250_abnormal_appendicular_skeleto0.75694446
111MP0002090_abnormal_vision0.74982693
112MP0000751_myopathy0.74785729
113MP0002108_abnormal_muscle_morphology0.74717512
114MP0002060_abnormal_skin_morphology0.74120262
115MP0000462_abnormal_digestive_system0.73933140
116MP0005195_abnormal_posterior_eye0.73690887
117MP0005253_abnormal_eye_physiology0.73608406
118MP0003879_abnormal_hair_cell0.71991973
119MP0004147_increased_porphyrin_level0.68671808
120MP0006072_abnormal_retinal_apoptosis0.68518566
121MP0000566_synostosis0.68369833
122MP0001943_abnormal_respiration0.68194521
123MP0003942_abnormal_urinary_system0.67799010
124MP0003123_paternal_imprinting0.67078678
125MP0000747_muscle_weakness0.65710263
126MP0002069_abnormal_eating/drinking_beha0.65511356
127MP0004085_abnormal_heartbeat0.65274086
128MP0002168_other_aberrant_phenotype0.64456873
129MP0003938_abnormal_ear_development0.64023048
130MP0003137_abnormal_impulse_conducting0.62836469
131MP0001346_abnormal_lacrimal_gland0.62606915
132MP0002751_abnormal_autonomic_nervous0.60951218
133MP0008874_decreased_physiological_sensi0.58607733
134MP0001348_abnormal_lacrimal_gland0.57200988
135MP0001664_abnormal_digestion0.57078292
136MP0010678_abnormal_skin_adnexa0.56139360
137MP0004036_abnormal_muscle_relaxation0.52889430
138MP0003861_abnormal_nervous_system0.51263565

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.92642525
2Focal motor seizures (HP:0011153)5.21536216
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.17373855
4Degeneration of the lateral corticospinal tracts (HP:0002314)5.17373855
5Myokymia (HP:0002411)4.90851833
6Neurofibrillary tangles (HP:0002185)4.89789743
7Aortic dissection (HP:0002647)4.38995808
8Protrusio acetabuli (HP:0003179)4.38835654
9Abnormality of the corticospinal tract (HP:0002492)4.29444464
10Supranuclear gaze palsy (HP:0000605)3.91143682
11Epileptic encephalopathy (HP:0200134)3.87368553
12Insidious onset (HP:0003587)3.70847749
13Termporal pattern (HP:0011008)3.70847749
14Ankle clonus (HP:0011448)3.63573853
15Cerebral inclusion bodies (HP:0100314)3.62779410
16Focal seizures (HP:0007359)3.61318400
17Peripheral hypomyelination (HP:0007182)3.54817193
18Arterial tortuosity (HP:0005116)3.44351100
19Spastic gait (HP:0002064)3.40411999
20Vascular tortuosity (HP:0004948)3.32553005
21Pheochromocytoma (HP:0002666)3.32185979
22Atonic seizures (HP:0010819)3.28095198
23Atrophic scars (HP:0001075)3.23234724
24Dysmetria (HP:0001310)3.19612727
25Soft skin (HP:0000977)3.19354461
26Broad metatarsal (HP:0001783)3.17049067
27Onion bulb formation (HP:0003383)3.11554801
28Scanning speech (HP:0002168)3.02569797
29Aortic aneurysm (HP:0004942)3.01484528
30Action tremor (HP:0002345)3.00272527
31Hyperventilation (HP:0002883)2.96096988
32Abnormality of dentin (HP:0010299)2.92142895
33Febrile seizures (HP:0002373)2.87355536
34Neuroendocrine neoplasm (HP:0100634)2.85711483
35Broad-based gait (HP:0002136)2.85120487
36Shallow orbits (HP:0000586)2.80131534
37Bladder diverticulum (HP:0000015)2.78516076
38Spondylolisthesis (HP:0003302)2.76602443
39Progressive cerebellar ataxia (HP:0002073)2.75432672
40Intention tremor (HP:0002080)2.72244062
41Dialeptic seizures (HP:0011146)2.70590271
42Parakeratosis (HP:0001036)2.69972200
43Retinal dysplasia (HP:0007973)2.69030398
44Genu recurvatum (HP:0002816)2.67112381
45Urinary urgency (HP:0000012)2.66956956
46Wormian bones (HP:0002645)2.66468014
47Overgrowth (HP:0001548)2.66145435
48Bowel diverticulosis (HP:0005222)2.64814620
49Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.64705161
50Sensory axonal neuropathy (HP:0003390)2.59960830
51Fragile skin (HP:0001030)2.59481864
52Absence seizures (HP:0002121)2.59402311
53Cerebral hypomyelination (HP:0006808)2.58734952
54Hyperextensible skin (HP:0000974)2.56782343
55Lower limb muscle weakness (HP:0007340)2.52620358
56Abnormal auditory evoked potentials (HP:0006958)2.51452914
57Dysdiadochokinesis (HP:0002075)2.44551189
58Mild short stature (HP:0003502)2.43762882
59Absent frontal sinuses (HP:0002688)2.42017305
60Generalized tonic-clonic seizures (HP:0002069)2.40632133
61Thickened helices (HP:0000391)2.38498538
62Truncal ataxia (HP:0002078)2.35461074
63Progressive inability to walk (HP:0002505)2.33386983
64Clumsiness (HP:0002312)2.32339845
65Segmental peripheral demyelination/remyelination (HP:0003481)2.31734703
66Urinary bladder sphincter dysfunction (HP:0002839)2.28476732
67Alacrima (HP:0000522)2.27970489
68Metaphyseal dysplasia (HP:0100255)2.27902747
69Mitral valve prolapse (HP:0001634)2.27130901
70Ulnar bowing (HP:0003031)2.26090399
71Visual hallucinations (HP:0002367)2.25792569
72Cerebral aneurysm (HP:0004944)2.24998428
73Ankle contracture (HP:0006466)2.19953521
74Aplasia involving bones of the upper limbs (HP:0009823)2.19281317
75Aplasia of the phalanges of the hand (HP:0009802)2.19281317
76Aplasia involving bones of the extremities (HP:0009825)2.19281317
77Absent septum pellucidum (HP:0001331)2.18424349
78Mitral stenosis (HP:0001718)2.18162071
79Follicular hyperkeratosis (HP:0007502)2.14545787
80Slow saccadic eye movements (HP:0000514)2.14161768
81Hypoventilation (HP:0002791)2.13806545
82Gaze-evoked nystagmus (HP:0000640)2.13395290
83Cardiovascular calcification (HP:0011915)2.12886798
84Abnormal eating behavior (HP:0100738)2.09672289
85Infantile muscular hypotonia (HP:0008947)2.09620448
86Mutism (HP:0002300)2.07591836
87Akinesia (HP:0002304)2.06208069
88Buphthalmos (HP:0000557)2.05839769
89Delayed gross motor development (HP:0002194)2.05809069
90Vaginal atresia (HP:0000148)2.04078401
91Neonatal short-limb short stature (HP:0008921)2.03649075
92Split foot (HP:0001839)2.02365921
93Hammertoe (HP:0001765)2.02133751
94Genital tract atresia (HP:0001827)2.01625321
95Impaired vibration sensation in the lower limbs (HP:0002166)2.00860979
96Bradycardia (HP:0001662)1.99546346
97Absent speech (HP:0001344)1.99410990
98Poor speech (HP:0002465)1.99262113
99Blue irides (HP:0000635)1.99214449
100Epileptiform EEG discharges (HP:0011182)1.99145051
101Megalencephaly (HP:0001355)1.98690760
102Excessive salivation (HP:0003781)1.98333768
103Drooling (HP:0002307)1.98333768
104Neuronal loss in central nervous system (HP:0002529)1.98258361
105Stridor (HP:0010307)1.97834208
106Hypoplastic pelvis (HP:0008839)1.97589501
107Autoamputation (HP:0001218)1.97434759
108Clonus (HP:0002169)1.97316343
109Limb dystonia (HP:0002451)1.96376015
110Anxiety (HP:0000739)1.95834985
111Pulmonic stenosis (HP:0001642)1.94586438
112Foot dorsiflexor weakness (HP:0009027)1.94222137
113Leukodystrophy (HP:0002415)1.94139986
114Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.94090876
115Cerebral hemorrhage (HP:0001342)1.93614641
116Ulnar claw (HP:0001178)1.93104810
117Congenital glaucoma (HP:0001087)1.92515429
118Decreased motor nerve conduction velocity (HP:0003431)1.92266619
119Generalized myoclonic seizures (HP:0002123)1.91784515
120Hemiparesis (HP:0001269)1.91011807
121Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.89435892
122Gait imbalance (HP:0002141)1.89322322
123Postural instability (HP:0002172)1.89120189
124Aortic regurgitation (HP:0001659)1.87696175
125Peritonitis (HP:0002586)1.84640185
126Coronal craniosynostosis (HP:0004440)1.84290332
127Anteriorly placed anus (HP:0001545)1.83412982
128Spastic tetraparesis (HP:0001285)1.83024729
129Abnormality of the septum pellucidum (HP:0007375)1.82978055
130Morphological abnormality of the pyramidal tract (HP:0002062)1.82868173
131EEG with generalized epileptiform discharges (HP:0011198)1.82866136
132Type II lissencephaly (HP:0007260)1.81924736
133Specific learning disability (HP:0001328)1.81418709
134Wide anterior fontanel (HP:0000260)1.80967664
135Abnormal hair whorl (HP:0010721)1.80877075
136Dilatation of the ascending aorta (HP:0005111)1.80625609
137Decreased lacrimation (HP:0000633)1.80428615
138Limited hip movement (HP:0008800)1.80202429
139Synostosis involving the elbow (HP:0003938)1.79567696
140Humeroradial synostosis (HP:0003041)1.79567696
141Widely spaced teeth (HP:0000687)1.79386406
142Abnormality of binocular vision (HP:0011514)1.78807301
143Diplopia (HP:0000651)1.78807301
144CNS hypomyelination (HP:0003429)1.78586354
145Torticollis (HP:0000473)1.78540671
146Increased circulating renin level (HP:0000848)1.78403905
147Osteolytic defects of the hand bones (HP:0009699)1.78242975
148Osteolytic defects of the phalanges of the hand (HP:0009771)1.78242975
149Depression (HP:0000716)1.77405561
150Hypoplasia of the iris (HP:0007676)1.75425389
151Enlarged penis (HP:0000040)1.72486641
152Osteoarthritis (HP:0002758)1.72121910
153Ectopia lentis (HP:0001083)1.72006186
154Blue sclerae (HP:0000592)1.70431948
155Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.67725774
156Focal dystonia (HP:0004373)1.67426811
157Hand muscle atrophy (HP:0009130)1.66894806
158Spinal rigidity (HP:0003306)1.66363478
159Mitral regurgitation (HP:0001653)1.64636159
160Upper limb amyotrophy (HP:0009129)1.63548071
161Distal upper limb amyotrophy (HP:0007149)1.63548071
162Postural tremor (HP:0002174)1.62944783
163Cervical subluxation (HP:0003308)1.59337607
164Papilledema (HP:0001085)1.59155122
165Craniofacial dystonia (HP:0012179)1.59078182
166Wrist flexion contracture (HP:0001239)1.58972694

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.15662976
2CASK3.63406333
3OXSR13.27486797
4NTRK32.73231756
5MARK12.55729795
6LATS22.46669524
7MYLK2.39907780
8EPHA42.29084728
9NTRK12.10802660
10FRK2.07646692
11PKN12.00372417
12CDK191.97793368
13MAPKAPK51.95250870
14BCR1.89896788
15TESK11.89860470
16MAP3K91.89256738
17PAK61.87079020
18PDGFRA1.84426567
19PRPF4B1.82592772
20MINK11.75619704
21PNCK1.75246568
22MAP3K41.74269717
23PTK21.73784027
24UHMK11.69015245
25MAP2K71.67726110
26FGFR21.67403217
27SGK2231.61077527
28SGK4941.61077527
29EPHB11.58468199
30WNK11.54806744
31LIMK11.52465220
32WNK41.50864550
33STK38L1.50132688
34NTRK21.44808419
35CAMK2B1.42765515
36TNIK1.37970829
37STK381.34058404
38PAK21.33886715
39NEK61.32301762
40CDK51.31533594
41ROCK21.23520168
42MAPK131.22345804
43PHKG11.18547161
44PHKG21.18547161
45CAMK2D1.16916837
46TTN1.16360177
47CAMK2A1.13147028
48CSNK1G31.11431005
49DAPK21.09100499
50CSNK1A1L1.08718690
51CSNK1G21.06685363
52DYRK21.05405296
53PLK21.04881797
54MAP2K41.04669283
55KSR21.03838419
56MET1.01186908
57DAPK31.00603785
58PAK31.00256919
59ROCK10.99892166
60PBK0.99338841
61MAP3K120.98634576
62ARAF0.95748044
63FGR0.95614422
64DMPK0.92724203
65CAMK2G0.92262417
66CDK140.91192703
67LATS10.89218561
68PRKCE0.88987631
69TRPM70.86744576
70ERBB30.86270832
71GRK50.84732341
72CDK180.84412830
73CDK150.83422356
74PRKG20.82571862
75MARK20.78733389
76MUSK0.78224276
77PINK10.77937041
78NEK90.76894639
79CSNK1G10.75779028
80SGK20.75036369
81PRKD30.74887424
82CAMKK20.74672633
83PRKCG0.74009836
84TYRO30.73070824
85CDK11A0.71512408
86RIPK10.71242043
87SGK30.70299155
88DYRK1A0.70140790
89GRK70.68538953
90MAP3K20.68009273
91FES0.67618771
92BMPR1B0.66297282
93DAPK10.65738276
94MAP3K130.64919557
95PRKCH0.63844324
96EPHB20.61859360
97PDGFRB0.61811293
98INSRR0.60502457
99DDR20.59899969
100TESK20.57462117
101PDPK10.56989554
102LMTK20.56850800
103KSR10.56034183
104PIK3CA0.55685650
105CLK10.54916919
106STK110.53946255
107ILK0.52004479
108CAMK1G0.51816162
109RET0.51601669
110PRKG10.51512962
111FYN0.50991711
112PTK2B0.49048467
113TIE10.48168944
114PRKCQ0.47460464
115PRKD10.47171627
116MAPK100.46979106
117SGK10.46057332
118CAMKK10.45873596
119CSNK1A10.45660088
120PRKD20.45196157
121FER0.44640937
122CAMK10.44568443
123BMPR20.44339157
124ADRBK20.44327448
125STK30.42781191
126FGFR10.42423003
127ICK0.41924935
128GSK3A0.41408778
129IRAK20.41380403
130PRKACB0.41280520
131WNK30.40896214
132FGFR30.40862386
133NME10.39508926
134RIPK40.38923177
135PRKACA0.38884910
136ERBB40.38696353

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.12934606
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.84276882
3Synaptic vesicle cycle_Homo sapiens_hsa047212.66998597
4GABAergic synapse_Homo sapiens_hsa047272.65131910
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.42572176
6Morphine addiction_Homo sapiens_hsa050322.32190436
7Glutamatergic synapse_Homo sapiens_hsa047242.30677202
8Fatty acid elongation_Homo sapiens_hsa000622.20189170
9Circadian entrainment_Homo sapiens_hsa047132.11721578
10Steroid biosynthesis_Homo sapiens_hsa001002.09576866
11ECM-receptor interaction_Homo sapiens_hsa045121.95749901
12Serotonergic synapse_Homo sapiens_hsa047261.89320248
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.88975116
14Olfactory transduction_Homo sapiens_hsa047401.88083650
15Collecting duct acid secretion_Homo sapiens_hsa049661.86147049
16Ether lipid metabolism_Homo sapiens_hsa005651.70703560
17Long-term depression_Homo sapiens_hsa047301.70070638
18Axon guidance_Homo sapiens_hsa043601.68990443
19Salivary secretion_Homo sapiens_hsa049701.68372783
20Dopaminergic synapse_Homo sapiens_hsa047281.68230740
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.67756822
22Taste transduction_Homo sapiens_hsa047421.56585277
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.55059592
24Amphetamine addiction_Homo sapiens_hsa050311.53589238
25Long-term potentiation_Homo sapiens_hsa047201.53473730
26Cocaine addiction_Homo sapiens_hsa050301.49136841
27Gastric acid secretion_Homo sapiens_hsa049711.47761542
28Cholinergic synapse_Homo sapiens_hsa047251.47621548
29Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.42624550
30Focal adhesion_Homo sapiens_hsa045101.41830024
31Vibrio cholerae infection_Homo sapiens_hsa051101.39800652
32Renin secretion_Homo sapiens_hsa049241.39020826
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.35099254
34Insulin secretion_Homo sapiens_hsa049111.34553150
35Protein digestion and absorption_Homo sapiens_hsa049741.34299775
36Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.32907974
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.32442239
38Phototransduction_Homo sapiens_hsa047441.26031755
39Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.23484138
40Oxidative phosphorylation_Homo sapiens_hsa001901.21418697
41SNARE interactions in vesicular transport_Homo sapiens_hsa041301.18722539
42Gap junction_Homo sapiens_hsa045401.18175853
43Oxytocin signaling pathway_Homo sapiens_hsa049211.14711257
44Hippo signaling pathway_Homo sapiens_hsa043901.12442666
45Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.09806285
46Cardiac muscle contraction_Homo sapiens_hsa042601.08190025
47Calcium signaling pathway_Homo sapiens_hsa040201.07876258
48Sphingolipid metabolism_Homo sapiens_hsa006001.07455477
49Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.06923521
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.03824969
51Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.99976396
52Circadian rhythm_Homo sapiens_hsa047100.98680871
53Aldosterone synthesis and secretion_Homo sapiens_hsa049250.97879246
54ErbB signaling pathway_Homo sapiens_hsa040120.96785960
55Maturity onset diabetes of the young_Homo sapiens_hsa049500.95804456
56Vascular smooth muscle contraction_Homo sapiens_hsa042700.95603843
57Folate biosynthesis_Homo sapiens_hsa007900.95167944
58Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.94828864
59Alzheimers disease_Homo sapiens_hsa050100.91437080
60cAMP signaling pathway_Homo sapiens_hsa040240.91062616
61Renal cell carcinoma_Homo sapiens_hsa052110.90805877
62Nitrogen metabolism_Homo sapiens_hsa009100.90427221
63GnRH signaling pathway_Homo sapiens_hsa049120.90121196
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.89839774
65Regulation of actin cytoskeleton_Homo sapiens_hsa048100.88607418
66Adherens junction_Homo sapiens_hsa045200.88528669
67Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.87792428
68Proteoglycans in cancer_Homo sapiens_hsa052050.87205002
69Dorso-ventral axis formation_Homo sapiens_hsa043200.85030122
70Sulfur metabolism_Homo sapiens_hsa009200.83131560
71Vitamin B6 metabolism_Homo sapiens_hsa007500.83033204
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.82080231
73Amoebiasis_Homo sapiens_hsa051460.80468705
74Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.80359591
75TGF-beta signaling pathway_Homo sapiens_hsa043500.79781105
76Ras signaling pathway_Homo sapiens_hsa040140.78369780
77Parkinsons disease_Homo sapiens_hsa050120.77658101
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.77466074
79Melanogenesis_Homo sapiens_hsa049160.75173007
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74480279
81Butanoate metabolism_Homo sapiens_hsa006500.73898171
82Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73497705
83Rheumatoid arthritis_Homo sapiens_hsa053230.72024161
84AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71739469
85Melanoma_Homo sapiens_hsa052180.70531280
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70083024
87cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68996706
88Pancreatic secretion_Homo sapiens_hsa049720.68973867
89Glucagon signaling pathway_Homo sapiens_hsa049220.67255766
90PI3K-Akt signaling pathway_Homo sapiens_hsa041510.65829306
91MAPK signaling pathway_Homo sapiens_hsa040100.64934560
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62492372
93Ovarian steroidogenesis_Homo sapiens_hsa049130.61597064
94Phagosome_Homo sapiens_hsa041450.61277917
95Endocytosis_Homo sapiens_hsa041440.61152686
96Dilated cardiomyopathy_Homo sapiens_hsa054140.60895803
97Estrogen signaling pathway_Homo sapiens_hsa049150.59091436
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58003178
99Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56162295
100Bile secretion_Homo sapiens_hsa049760.55870373
101Choline metabolism in cancer_Homo sapiens_hsa052310.55303959
102Linoleic acid metabolism_Homo sapiens_hsa005910.55026861
103Oocyte meiosis_Homo sapiens_hsa041140.54649538
104Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54235392
105Tight junction_Homo sapiens_hsa045300.53146532
106Arginine and proline metabolism_Homo sapiens_hsa003300.52681452
107Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.52310157
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.48585114
109Glioma_Homo sapiens_hsa052140.46751301
110Hedgehog signaling pathway_Homo sapiens_hsa043400.46574881
111Protein export_Homo sapiens_hsa030600.46034806
112alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45982678
113Glycosaminoglycan degradation_Homo sapiens_hsa005310.45823077
114Rap1 signaling pathway_Homo sapiens_hsa040150.45422726
115Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44817830
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44813553
117Histidine metabolism_Homo sapiens_hsa003400.44100719
118Type II diabetes mellitus_Homo sapiens_hsa049300.43246121
119Alcoholism_Homo sapiens_hsa050340.42646225
120Mineral absorption_Homo sapiens_hsa049780.41837714
121Thyroid hormone synthesis_Homo sapiens_hsa049180.41609144
122Inositol phosphate metabolism_Homo sapiens_hsa005620.40177887
123Wnt signaling pathway_Homo sapiens_hsa043100.39729923
124Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38772822
125Prion diseases_Homo sapiens_hsa050200.37662000
126Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31753835

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