EDN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a preproprotein that is proteolytically processed to generate a secreted peptide that belongs to the endothelin/sarafotoxin family. This peptide is a potent vasoconstrictor and its cognate receptors are therapeutic targets in the treatment of pulmonary arterial hypertension. Aberrant expression of this gene may promote tumorigenesis. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lymph vessel development (GO:0001945)6.12862297
2endothelium development (GO:0003158)5.49815830
3positive regulation of endothelial cell differentiation (GO:0045603)5.44398324
4wound healing, spreading of epidermal cells (GO:0035313)4.86874664
5negative regulation of blood vessel endothelial cell migration (GO:0043537)4.85614836
6angiogenesis involved in wound healing (GO:0060055)4.45390600
7positive regulation of vasculogenesis (GO:2001214)4.39581656
8cellular extravasation (GO:0045123)4.33608833
9cell adhesion mediated by integrin (GO:0033627)4.18273881
10negative regulation of chondrocyte differentiation (GO:0032331)4.11429386
11vascular endothelial growth factor signaling pathway (GO:0038084)4.10042628
12monocyte chemotaxis (GO:0002548)4.03859408
13regulation of blood vessel endothelial cell migration (GO:0043535)4.02418929
14regulation of vasculogenesis (GO:2001212)3.97429490
15lymphangiogenesis (GO:0001946)3.94637492
16endothelial cell morphogenesis (GO:0001886)3.86836163
17regulation of glomerular filtration (GO:0003093)3.84583463
18regulation of plasminogen activation (GO:0010755)3.72760170
19negative regulation of focal adhesion assembly (GO:0051895)3.70526690
20negative regulation of cell junction assembly (GO:1901889)3.70526690
21negative regulation of adherens junction organization (GO:1903392)3.70526690
22regulation of cellular extravasation (GO:0002691)3.68708149
23modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.67516842
24positive regulation by organism of defense response of other organism involved in symbiotic interact3.67516842
25modulation by symbiont of host immune response (GO:0052553)3.67516842
26positive regulation by symbiont of host defense response (GO:0052509)3.67516842
27modulation by symbiont of host defense response (GO:0052031)3.67516842
28modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.67516842
29regulation of transforming growth factor beta1 production (GO:0032908)3.63325991
30artery development (GO:0060840)3.62479959
31adhesion of symbiont to host (GO:0044406)3.59719386
32wound healing, spreading of cells (GO:0044319)3.57380928
33lipopolysaccharide-mediated signaling pathway (GO:0031663)3.56862868
34negative regulation of endothelial cell migration (GO:0010596)3.56331650
35pathway-restricted SMAD protein phosphorylation (GO:0060389)3.51869483
36positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)3.50566495
37positive regulation of blood vessel endothelial cell migration (GO:0043536)3.48619100
38membrane raft organization (GO:0031579)3.44769406
39substrate adhesion-dependent cell spreading (GO:0034446)3.43321584
40regulation of endothelial cell differentiation (GO:0045601)3.42955032
41positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.42550712
42regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.42550712
43retina vasculature morphogenesis in camera-type eye (GO:0061299)3.42167272
44regulation of podosome assembly (GO:0071801)3.40006034
45surfactant homeostasis (GO:0043129)3.38292071
46lung vasculature development (GO:0060426)3.38101047
47Notch signaling involved in heart development (GO:0061314)3.32961702
48regulation of fever generation (GO:0031620)3.30410655
49protein localization to endosome (GO:0036010)3.29007570
50angiogenesis (GO:0001525)3.27854697
51transcytosis (GO:0045056)3.24061057
52renal filtration (GO:0097205)3.23890288
53regulation of T-helper 1 cell differentiation (GO:0045625)3.21846198
54positive regulation of chemokine biosynthetic process (GO:0045080)3.21308506
55endothelial cell proliferation (GO:0001935)3.21012265
56positive regulation of endothelial cell apoptotic process (GO:2000353)3.20538985
57endocardial cushion development (GO:0003197)3.19267930
58positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.16151072
59* regulation of endothelial cell migration (GO:0010594)3.14724278
60regulation of cell proliferation involved in kidney development (GO:1901722)3.14518412
61* positive regulation of endothelial cell migration (GO:0010595)3.14208985
62positive regulation of osteoblast proliferation (GO:0033690)3.14069245
63cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.13847888
64regulation of chondrocyte differentiation (GO:0032330)3.13261186
65negative regulation of endothelial cell proliferation (GO:0001937)3.12390707
66positive regulation of heat generation (GO:0031652)3.11655856
67regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.11075959
68blood vessel maturation (GO:0001955)3.10806052
69peptidyl-tyrosine autophosphorylation (GO:0038083)3.08647830
70endothelial tube morphogenesis (GO:0061154)3.06585728
71morphogenesis of an endothelium (GO:0003159)3.06585728
72Golgi transport vesicle coating (GO:0048200)3.06051124
73COPI coating of Golgi vesicle (GO:0048205)3.06051124
74response to muramyl dipeptide (GO:0032495)3.05825901
75glomerular filtration (GO:0003094)3.04967026
76regulation of apoptotic process involved in morphogenesis (GO:1902337)3.04827129
77response to magnesium ion (GO:0032026)3.04267812
78regulation of vitamin metabolic process (GO:0030656)3.04261135
79endodermal cell differentiation (GO:0035987)3.03684766
80positive regulation of cartilage development (GO:0061036)3.01212808
81vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.00270259
82* patterning of blood vessels (GO:0001569)2.99310555
83substrate-dependent cell migration (GO:0006929)2.98705495
84negative regulation of anoikis (GO:2000811)2.98460022
85establishment of endothelial barrier (GO:0061028)2.98216090
86mesodermal cell differentiation (GO:0048333)2.97960723
87negative regulation of nitric oxide biosynthetic process (GO:0045019)2.96248053
88negative regulation of cartilage development (GO:0061037)2.96148885
89positive regulation of calcium ion import (GO:0090280)2.95042958
90branching involved in salivary gland morphogenesis (GO:0060445)2.93965697
91apoptotic cell clearance (GO:0043277)2.93520201
92* positive regulation of epithelial cell migration (GO:0010634)2.92670169
93adhesion of symbiont to host cell (GO:0044650)2.90987104
94virion attachment to host cell (GO:0019062)2.90987104
95positive regulation of macrophage activation (GO:0043032)2.88873527
96positive regulation of receptor recycling (GO:0001921)2.87858140
97positive regulation of monocyte chemotaxis (GO:0090026)2.87068157
98positive regulation of glomerulus development (GO:0090193)2.85782070
99regulation of cardioblast differentiation (GO:0051890)2.85747977
100endothelial cell differentiation (GO:0045446)2.85349288
101negative regulation of cell-substrate adhesion (GO:0010812)2.83314291
102positive regulation of respiratory burst (GO:0060267)2.82281003
103neuron remodeling (GO:0016322)2.81888718
104detection of molecule of bacterial origin (GO:0032490)2.81522407
105mRNA transcription (GO:0009299)2.79938156
106Rap protein signal transduction (GO:0032486)2.79681272
107negative regulation of DNA biosynthetic process (GO:2000279)2.79148201
108positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.79024099
109sprouting angiogenesis (GO:0002040)2.78617062
110ovulation (GO:0030728)2.78345460
111negative regulation of cell-matrix adhesion (GO:0001953)2.77502109
112regulation of cartilage development (GO:0061035)2.77190822
113regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.76613759
114positive regulation of interferon-alpha production (GO:0032727)2.76097441
115positive regulation of hair cycle (GO:0042635)2.75987223
116positive regulation of hair follicle development (GO:0051798)2.75987223
117hemidesmosome assembly (GO:0031581)2.75441293
118regulation of mononuclear cell migration (GO:0071675)2.75414108
119response to host immune response (GO:0052572)2.75188056
120response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.75188056
121ovulation from ovarian follicle (GO:0001542)2.74327604
122regulation of heterotypic cell-cell adhesion (GO:0034114)2.74084221
123bundle of His cell to Purkinje myocyte communication (GO:0086069)2.73687321
124COPII vesicle coating (GO:0048208)2.73647055
125response to peptidoglycan (GO:0032494)2.73645787
126macrophage activation (GO:0042116)2.73087589
127negative regulation of fibrinolysis (GO:0051918)2.72720467
128blood vessel remodeling (GO:0001974)2.72153564
129positive regulation of NF-kappaB import into nucleus (GO:0042346)2.71803118
130positive regulation of toll-like receptor signaling pathway (GO:0034123)2.71623039
131radial glial cell differentiation (GO:0060019)2.70850939
132* regulation of epithelial cell migration (GO:0010632)2.69670052
133regulation of pathway-restricted SMAD protein phosphorylation (GO:0060393)2.69432097
134desmosome organization (GO:0002934)2.69255396
135regulation of integrin activation (GO:0033623)2.68829098
136positive regulation of actin filament depolymerization (GO:0030836)2.68444549
137regulation of interferon-alpha production (GO:0032647)2.67911941
138positive regulation of interleukin-8 secretion (GO:2000484)2.67887052
139negative regulation of fatty acid transport (GO:2000192)2.65701990
140positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.65685888
141chemical homeostasis within a tissue (GO:0048875)2.65016168
142membrane protein ectodomain proteolysis (GO:0006509)2.63798585
143tissue remodeling (GO:0048771)2.63627446
144endothelial cell chemotaxis (GO:0035767)2.63281579
145regulation of focal adhesion assembly (GO:0051893)2.61981187
146regulation of cell-substrate junction assembly (GO:0090109)2.61981187
147regulation of chemokine biosynthetic process (GO:0045073)2.61781701
148cell migration involved in sprouting angiogenesis (GO:0002042)2.60759073
149regulation of macrophage chemotaxis (GO:0010758)2.60660888
150positive regulation of focal adhesion assembly (GO:0051894)2.60059545
151positive regulation of cell junction assembly (GO:1901890)2.60059545
152positive regulation of interleukin-1 beta secretion (GO:0050718)2.59945131
153heparin metabolic process (GO:0030202)2.59178868
154positive regulation of interleukin-6 production (GO:0032755)2.58688906
155regulation of heat generation (GO:0031650)2.58268669
156positive regulation of lymphocyte migration (GO:2000403)2.57612661
157regulation of metalloenzyme activity (GO:0048552)2.57560372
158* regulation of nitric oxide biosynthetic process (GO:0045428)2.56022716
159regulation of vitamin D biosynthetic process (GO:0060556)2.55456173
160regulation of endothelial cell apoptotic process (GO:2000351)2.52612634
161regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.51335799
162microglial cell activation (GO:0001774)2.50238084
163cellular response to exogenous dsRNA (GO:0071360)2.49955401
164regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.48714528
165response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.47670871
166response to host (GO:0075136)2.47670871
167response to host defenses (GO:0052200)2.47670871
168eosinophil chemotaxis (GO:0048245)2.47652322
169positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.47285153
170* positive regulation of nitric oxide biosynthetic process (GO:0045429)2.47127021
171ventricular trabecula myocardium morphogenesis (GO:0003222)2.46446683
172natural killer cell activation involved in immune response (GO:0002323)2.42642643
173basement membrane organization (GO:0071711)2.41736859

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.73968434
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.44169802
3* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.48264832
4TRIM28_21343339_ChIP-Seq_HEK293_Human4.27313958
5* GATA2_21666600_ChIP-Seq_HMVEC_Human2.78733660
6* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.78459913
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.68331445
8* SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.43950028
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.41361665
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.28155869
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.18483064
12* CDX2_19796622_ChIP-Seq_MESCs_Mouse2.18293479
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.18150008
14* SOX2_20726797_ChIP-Seq_SW620_Human2.12100274
15SMAD_19615063_ChIP-ChIP_OVARY_Human2.02011198
16PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.95545996
17RARG_19884340_ChIP-ChIP_MEFs_Mouse1.95186924
18* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.92845718
19KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.92022985
20* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.89109734
21* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.86298915
22* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.86298915
23FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.86287522
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.85897989
25* CDX2_20551321_ChIP-Seq_CACO-2_Human1.85642583
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.84680830
27CJUN_26792858_Chip-Seq_BT549_Human1.83353387
28* ESR1_21235772_ChIP-Seq_MCF-7_Human1.82045336
29RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.78656698
30HIF1A_21447827_ChIP-Seq_MCF-7_Human1.73958949
31PPAR_26484153_Chip-Seq_NCI-H1993_Human1.65824789
32* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.63194714
33STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.61222398
34* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.54876844
35FOXO3_23340844_ChIP-Seq_DLD1_Human1.50962220
36* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.50607832
37CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.49832262
38VDR_24787735_ChIP-Seq_THP-1_Human1.46125075
39IRF8_27001747_Chip-Seq_BMDM_Mouse1.46042821
40STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.45037590
41NRF2_20460467_ChIP-Seq_MEFs_Mouse1.44783788
42NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.44783788
43* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.42480467
44STAT6_21828071_ChIP-Seq_BEAS2B_Human1.40675000
45STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.38334433
46TBX20_22328084_ChIP-Seq_HEART_Mouse1.38005097
47TBX20_22080862_ChIP-Seq_HEART_Mouse1.38005097
48KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.35552179
49JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.35049633
50FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.34704486
51NFIB_24661679_ChIP-Seq_LUNG_Mouse1.33664269
52EP300_21415370_ChIP-Seq_HL-1_Mouse1.32262362
53TP53_18474530_ChIP-ChIP_U2OS_Human1.31448705
54* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.31251886
55* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.27197361
56PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25979547
57TCF4_18268006_ChIP-ChIP_LS174T_Human1.24446451
58ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.24428377
59ATF3_27146783_Chip-Seq_COLON_Human1.23595204
60FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.22829548
61TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.21824957
62* ESR2_21235772_ChIP-Seq_MCF-7_Human1.21663535
63* AHR_22903824_ChIP-Seq_MCF-7_Human1.19998691
64P300_27058665_Chip-Seq_ZR-75-30cells_Human1.19962838
65NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.17917978
66PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.17255250
67SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.13827525
68JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13466675
69WT1_19549856_ChIP-ChIP_CCG9911_Human1.13153934
70NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.12815265
71ZNF263_19887448_ChIP-Seq_K562_Human1.12100200
72SOX9_24532713_ChIP-Seq_HFSC_Mouse1.11383723
73* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.10706034
74ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09270194
75NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.08962032
76GATA4_25053715_ChIP-Seq_YYC3_Human1.08327051
77MYB_21317192_ChIP-Seq_ERMYB_Mouse1.07324183
78EED_16625203_ChIP-ChIP_MESCs_Mouse1.07235792
79TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.05287571
80* GATA3_24758297_ChIP-Seq_MCF-7_Human1.04913663
81PIAS1_25552417_ChIP-Seq_VCAP_Human1.04714908
82EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.04567190
83PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.03955077
84TP53_16413492_ChIP-PET_HCT116_Human1.03688832
85CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03197556
86ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01853810
87EGR1_19374776_ChIP-ChIP_THP-1_Human1.01296329
88* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.00370099
89P63_26484246_Chip-Seq_KERATINOCYTES_Human1.00087288
90TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.99985854
91HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.99928795
92NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.99906931
93RACK7_27058665_Chip-Seq_MCF-7_Human0.99217719
94MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.99011568
95* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.97786787
96* SMAD3_21741376_ChIP-Seq_HESCs_Human0.96573454
97CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.96366074
98* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.94531157
99BRD4_25478319_ChIP-Seq_HGPS_Human0.94225385
100NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.92993042
101* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.91478719
102TP53_22127205_ChIP-Seq_IMR90_Human0.90470971
103* SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.88447998
104FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.87655419
105CLOCK_20551151_ChIP-Seq_293T_Human0.87267575
106KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.86859005
107KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.86859005
108KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.86859005
109BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.85136903
110* LXR_22158963_ChIP-Seq_LIVER_Mouse0.85096623
111NOTCH1_21737748_ChIP-Seq_TLL_Human0.82508229
112ESR1_20079471_ChIP-ChIP_T-47D_Human0.81650189
113* TP63_23658742_ChIP-Seq_EP156T_Human0.81441043
114* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.79686035
115BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.79307965
116RUNX_20019798_ChIP-Seq_JUKART_Human0.79284334
117PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.79024764
118TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.78642866
119* RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.78610535
120CTNNB1_20460455_ChIP-Seq_HCT116_Human0.78554783
121PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.77814227
122TCF3_18692474_ChIP-Seq_MEFs_Mouse0.77811546
123KLF5_25053715_ChIP-Seq_YYC3_Human0.76156367
124PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.75452204
125* SMAD4_21741376_ChIP-Seq_HESCs_Human0.75223304
126ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.74905424
127* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.74737550
128STAT4_19710469_ChIP-ChIP_TH1__Mouse0.74342214
129UBF1/2_26484160_Chip-Seq_HMECs_Human0.74039165
130* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.73155652
131* GATA6_25053715_ChIP-Seq_YYC3_Human0.72517697
132ELK3_25401928_ChIP-Seq_HUVEC_Human0.70672798
133* ELK1_22589737_ChIP-Seq_MCF10A_Human0.70283011
134MTF2_20144788_ChIP-Seq_MESCs_Mouse0.69917117
135* SOX17_20123909_ChIP-Seq_XEN_Mouse0.69641061
136AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.68541361
137* ARNT_22903824_ChIP-Seq_MCF-7_Human0.68285877
138IGF1R_20145208_ChIP-Seq_DFB_Human0.67035939
139IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.66757016

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005167_abnormal_blood-brain_barrier4.54468556
2MP0003724_increased_susceptibility_to4.54422048
3MP0001879_abnormal_lymphatic_vessel4.43588577
4MP0010368_abnormal_lymphatic_system4.36160036
5MP0008438_abnormal_cutaneous_collagen3.32054699
6MP0008004_abnormal_stomach_pH3.31264501
7MP0004272_abnormal_basement_membrane3.31214885
8MP0009379_abnormal_foot_pigmentation3.01162868
9MP0003705_abnormal_hypodermis_morpholog2.97509119
10MP0005623_abnormal_meninges_morphology2.92634854
11MP0003828_pulmonary_edema2.86250883
12MP0009785_altered_susceptibility_to2.46527059
13MP0006082_CNS_inflammation2.33627867
14MP0003941_abnormal_skin_development2.32776866
15MP0005084_abnormal_gallbladder_morpholo2.31925807
16MP0002148_abnormal_hypersensitivity_rea2.21847823
17MP0004233_abnormal_muscle_weight2.21270888
18MP0000465_gastrointestinal_hemorrhage2.18895603
19MP0003191_abnormal_cellular_cholesterol2.17935945
20MP0002138_abnormal_hepatobiliary_system2.14057679
21MP0006054_spinal_hemorrhage2.09127842
22MP0004782_abnormal_surfactant_physiolog1.98198622
23MP0009764_decreased_sensitivity_to1.92264043
24MP0005164_abnormal_response_to1.91216462
25MP0009278_abnormal_bone_marrow1.86364788
26MP0003303_peritoneal_inflammation1.84907590
27MP0004883_abnormal_blood_vessel1.84034981
28MP0005165_increased_susceptibility_to1.82540382
29MP0005275_abnormal_skin_tensile1.72583839
30MP0000767_abnormal_smooth_muscle1.69063046
31MP0009780_abnormal_chondrocyte_physiolo1.67136920
32MP0002419_abnormal_innate_immunity1.63491152
33MP0002877_abnormal_melanocyte_morpholog1.61257859
34MP0002332_abnormal_exercise_endurance1.60801401
35MP0003453_abnormal_keratinocyte_physiol1.59688972
36MP0000343_altered_response_to1.59574573
37MP0003300_gastrointestinal_ulcer1.59409476
38MP0001188_hyperpigmentation1.57850338
39MP0010155_abnormal_intestine_physiology1.56931416
40MP0003950_abnormal_plasma_membrane1.56252380
41MP0000249_abnormal_blood_vessel1.55455502
42MP0005171_absent_coat_pigmentation1.55129163
43MP0005595_abnormal_vascular_smooth1.54176449
44MP0003436_decreased_susceptibility_to1.53568906
45MP0004147_increased_porphyrin_level1.53107209
46MP0004947_skin_inflammation1.50024675
47MP0001533_abnormal_skeleton_physiology1.46823559
48MP0000013_abnormal_adipose_tissue1.46294890
49MP0005000_abnormal_immune_tolerance1.46292394
50MP0002254_reproductive_system_inflammat1.45487670
51MP0003448_altered_tumor_morphology1.45130047
52MP0010030_abnormal_orbit_morphology1.44687711
53MP0002295_abnormal_pulmonary_circulatio1.44059549
54MP0003091_abnormal_cell_migration1.43325029
55MP0002933_joint_inflammation1.43282741
56MP0005025_abnormal_response_to1.40028769
57MP0003868_abnormal_feces_composition1.37981728
58MP0000516_abnormal_urinary_system1.37109951
59MP0005367_renal/urinary_system_phenotyp1.37109951
60* MP0004484_altered_response_of1.36379699
61MP0003566_abnormal_cell_adhesion1.32446160
62MP0010234_abnormal_vibrissa_follicle1.30770850
63MP0009697_abnormal_copulation1.27983918
64MP0005257_abnormal_intraocular_pressure1.25553007
65MP0002168_other_aberrant_phenotype1.22355039
66MP0005360_urolithiasis1.21036230
67MP0002098_abnormal_vibrissa_morphology1.16156353
68MP0005197_abnormal_uvea_morphology1.09955335
69MP0002998_abnormal_bone_remodeling1.09114960
70MP0001853_heart_inflammation1.09100500
71MP0001958_emphysema1.07093910
72MP0006138_congestive_heart_failure1.06188124
73MP0002452_abnormal_antigen_presenting1.05590400
74MP0003943_abnormal_hepatobiliary_system1.05119977
75MP0005501_abnormal_skin_physiology1.04119950
76MP0003279_aneurysm1.01373665
77MP0001851_eye_inflammation1.00352083
78MP0003045_fibrosis1.00207732
79MP0005408_hypopigmentation0.99608714
80MP0002972_abnormal_cardiac_muscle0.99213412
81MP0002896_abnormal_bone_mineralization0.99015911
82MP0005083_abnormal_biliary_tract0.98939641
83MP0000467_abnormal_esophagus_morphology0.98843735
84MP0010352_gastrointestinal_tract_polyps0.98364589
85MP0002928_abnormal_bile_duct0.96701068
86* MP0002925_abnormal_cardiovascular_devel0.94876629
87MP0005390_skeleton_phenotype0.94645771
88MP0002133_abnormal_respiratory_system0.94113202
89MP0005388_respiratory_system_phenotype0.94113202
90MP0001845_abnormal_inflammatory_respons0.93020642
91MP0002723_abnormal_immune_serum0.92802720
92MP0001348_abnormal_lacrimal_gland0.92734693
93MP0001835_abnormal_antigen_presentation0.90750943
94MP0001545_abnormal_hematopoietic_system0.90419318
95MP0005397_hematopoietic_system_phenotyp0.90419318
96MP0009840_abnormal_foam_cell0.89834735
97MP0001542_abnormal_bone_strength0.89142519
98MP0002006_tumorigenesis0.88846934
99MP0001849_ear_inflammation0.88666791
100MP0005387_immune_system_phenotype0.87625730
101MP0001790_abnormal_immune_system0.87625730
102MP0009333_abnormal_splenocyte_physiolog0.86247549
103* MP0001614_abnormal_blood_vessel0.85204065
104MP0002128_abnormal_blood_circulation0.84846357
105MP0002405_respiratory_system_inflammati0.84822301
106MP0001873_stomach_inflammation0.84737217
107MP0000537_abnormal_urethra_morphology0.84380868
108MP0005023_abnormal_wound_healing0.83018447
109MP0005330_cardiomyopathy0.79801296
110MP0000750_abnormal_muscle_regeneration0.79759815
111MP0004084_abnormal_cardiac_muscle0.79730657
112MP0005503_abnormal_tendon_morphology0.79646603
113MP0001819_abnormal_immune_cell0.79472360
114MP0009053_abnormal_anal_canal0.77445951
115MP0003385_abnormal_body_wall0.76678937
116MP0002420_abnormal_adaptive_immunity0.76611672
117MP0003075_altered_response_to0.76550507
118* MP0005166_decreased_susceptibility_to0.76049895
119MP0002086_abnormal_extraembryonic_tissu0.75586983
120MP0001243_abnormal_dermal_layer0.75252139
121MP0002060_abnormal_skin_morphology0.74730382
122MP0010678_abnormal_skin_adnexa0.74667648
123MP0008469_abnormal_protein_level0.74401486
124MP0005409_darkened_coat_color0.73924053
125MP0001915_intracranial_hemorrhage0.73707838
126MP0001544_abnormal_cardiovascular_syste0.72573458
127MP0005385_cardiovascular_system_phenoty0.72573458
128MP0004264_abnormal_extraembryonic_tissu0.71510549
129MP0003984_embryonic_growth_retardation0.70645486
130MP0008775_abnormal_heart_ventricle0.69589980
131MP0002088_abnormal_embryonic_growth/wei0.69210990
132MP0003638_abnormal_response/metabolism_0.68947233
133MP0001191_abnormal_skin_condition0.68921403
134MP0000733_abnormal_muscle_development0.67871345
135MP0001663_abnormal_digestive_system0.67469724
136MP0005395_other_phenotype0.66479274
137MP0002796_impaired_skin_barrier0.65957022
138MP0000534_abnormal_ureter_morphology0.63095450
139MP0001784_abnormal_fluid_regulation0.61679176
140MP0000858_altered_metastatic_potential0.61492249
141MP0000003_abnormal_adipose_tissue0.60769128
142MP0005248_abnormal_Harderian_gland0.60416406
143MP0005508_abnormal_skeleton_morphology0.60168391
144MP0001666_abnormal_nutrient_absorption0.55136977
145MP0002282_abnormal_trachea_morphology0.54772404

Predicted human phenotypes

RankGene SetZ-score
1Absent hand (HP:0004050)5.95533853
2Protrusio acetabuli (HP:0003179)5.07132735
3Esophageal varix (HP:0002040)4.95143590
4Premature rupture of membranes (HP:0001788)4.65185188
5Adactyly (HP:0009776)4.40085037
6Aortic dissection (HP:0002647)4.23480880
7Porencephaly (HP:0002132)3.88706955
8Congenital sensorineural hearing impairment (HP:0008527)3.86184566
9Cerebral aneurysm (HP:0004944)3.72399735
10Autoimmune thrombocytopenia (HP:0001973)3.49206138
11Onycholysis (HP:0001806)3.41442501
12Menorrhagia (HP:0000132)3.40646689
13Aplasia cutis congenita (HP:0001057)3.39005102
14Xerostomia (HP:0000217)3.33743555
15Wrist flexion contracture (HP:0001239)3.32850255
16Interstitial pulmonary disease (HP:0006530)3.31867894
17Aortic aneurysm (HP:0004942)3.26507417
18Spontaneous hematomas (HP:0007420)3.16674117
19Portal hypertension (HP:0001409)3.13933215
20Cervical subluxation (HP:0003308)3.10917025
21Abnormal hemoglobin (HP:0011902)3.06079933
22Stomatitis (HP:0010280)3.03152252
23Hematochezia (HP:0002573)3.02678526
24Eczematoid dermatitis (HP:0000976)3.01491921
25Cerebral hemorrhage (HP:0001342)2.98256750
26Orchitis (HP:0100796)2.91067049
27Fused cervical vertebrae (HP:0002949)2.89813226
28Abnormality of the hepatic vasculature (HP:0006707)2.86633181
29Subacute progressive viral hepatitis (HP:0006572)2.85448955
30Spondylolisthesis (HP:0003302)2.83719552
31Nonimmune hydrops fetalis (HP:0001790)2.82920823
32Recurrent abscess formation (HP:0002722)2.81762305
33Thick nail (HP:0001805)2.81447714
34Distal lower limb muscle weakness (HP:0009053)2.80701859
35Wormian bones (HP:0002645)2.80392538
36Pulmonary artery stenosis (HP:0004415)2.75082082
37Mitral valve prolapse (HP:0001634)2.74715491
38Skull defect (HP:0001362)2.69895767
39Hydroureter (HP:0000072)2.66969960
40Micronodular cirrhosis (HP:0001413)2.65256833
41Absent toe (HP:0010760)2.57028522
42Overgrowth (HP:0001548)2.54279142
43Tetraparesis (HP:0002273)2.51959179
44Polycythemia (HP:0001901)2.51372534
45Ileus (HP:0002595)2.50675138
46Elevated erythrocyte sedimentation rate (HP:0003565)2.49980001
47Mediastinal lymphadenopathy (HP:0100721)2.49617553
48Broad face (HP:0000283)2.49308347
49Glucose intolerance (HP:0000833)2.48271211
50Leiomyosarcoma (HP:0100243)2.47632774
51Uterine leiomyosarcoma (HP:0002891)2.47632774
52Cardiovascular calcification (HP:0011915)2.47169700
53Retrobulbar optic neuritis (HP:0100654)2.46548514
54Optic neuritis (HP:0100653)2.46548514
55Flat acetabular roof (HP:0003180)2.45224839
56Abnormality of the nasal septum (HP:0000419)2.44696870
57Nausea (HP:0002018)2.43041779
58Neonatal death (HP:0003811)2.42961596
59Abnormality of the intrinsic pathway (HP:0010989)2.41101948
60Ventricular fibrillation (HP:0001663)2.40976342
61Ectopia lentis (HP:0001083)2.39919189
62Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.34457243
63Aneurysm (HP:0002617)2.33170203
64Soft skin (HP:0000977)2.32090345
65Pustule (HP:0200039)2.30777163
66Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.30766093
67Hemangiomatosis (HP:0007461)2.29955501
68Short nail (HP:0001799)2.29786321
69Coxa vara (HP:0002812)2.29685222
70Impaired platelet aggregation (HP:0003540)2.29624254
71Abnormal platelet function (HP:0011869)2.29624254
72Vascular tortuosity (HP:0004948)2.28183621
73Visceral angiomatosis (HP:0100761)2.27130834
74Abnormality of macrophages (HP:0004311)2.27056453
75Abnormality of the vasculature of the conjunctiva (HP:0008054)2.25851958
76Recurrent gram-negative bacterial infections (HP:0005420)2.25215669
77Abnormal vertebral ossification (HP:0100569)2.24582621
78Pulmonary hypertension (HP:0002092)2.23717614
79Anhidrosis (HP:0000970)2.22887259
80Abnormality of iron homeostasis (HP:0011031)2.22442110
81Coxa valga (HP:0002673)2.21824414
82Myositis (HP:0100614)2.19844461
83Blue sclerae (HP:0000592)2.18907244
84Vascular calcification (HP:0004934)2.18447362
85Conjunctival telangiectasia (HP:0000524)2.15804610
86Abnormality of the acetabulum (HP:0003170)2.13969371
87Abnormality of the nasal mucosa (HP:0000433)2.13957083
88Segmental peripheral demyelination/remyelination (HP:0003481)2.13845770
89Vertebral clefting (HP:0008428)2.13119692
90Hypoplasia of the iris (HP:0007676)2.12986895
91Trismus (HP:0000211)2.11143964
92Congenital, generalized hypertrichosis (HP:0004540)2.10980355
93Joint contractures involving the joints of the feet (HP:0100492)2.10405872
94Flexion contracture of toe (HP:0005830)2.10405872
95Parakeratosis (HP:0001036)2.09013746
96Hyporeflexia of lower limbs (HP:0002600)2.09001476
97Osteolytic defects of the phalanges of the hand (HP:0009771)2.07491237
98Osteolytic defects of the hand bones (HP:0009699)2.07491237
99Vacuolated lymphocytes (HP:0001922)2.05827197
100Stroke (HP:0001297)2.05141699
101Pigmentary retinal degeneration (HP:0001146)2.03964425
102Subcapsular cataract (HP:0000523)2.03584499
103Lymphangioma (HP:0100764)2.02628139
104Gingivitis (HP:0000230)2.01805859
105Aortic valve stenosis (HP:0001650)2.01119151
106Arterial tortuosity (HP:0005116)2.00130305
107Bladder diverticulum (HP:0000015)1.98736469
108Hypoglycemic seizures (HP:0002173)1.98683532
109Axonal loss (HP:0003447)1.98057558
110Transitional cell carcinoma of the bladder (HP:0006740)1.97484428
111Atrophic scars (HP:0001075)1.97102459
112Symptomatic seizures (HP:0011145)1.96435804
113Amniotic constriction ring (HP:0009775)1.95191029
114Abnormality of placental membranes (HP:0011409)1.95191029
115Recurrent bacterial skin infections (HP:0005406)1.93703332
116Dilatation of the ascending aorta (HP:0005111)1.93631812
117Basal ganglia calcification (HP:0002135)1.92703626
118Myocardial infarction (HP:0001658)1.92427681
119Striae distensae (HP:0001065)1.91330410
120Urinary glycosaminoglycan excretion (HP:0003541)1.90480080
121Mucopolysacchariduria (HP:0008155)1.90480080
122Fragile skin (HP:0001030)1.90223013
123Joint stiffness (HP:0001387)1.88343556
124Bladder carcinoma (HP:0002862)1.88090201
125Bladder neoplasm (HP:0009725)1.88090201
126Shallow orbits (HP:0000586)1.87903863
127Mutism (HP:0002300)1.87629062
128Premature loss of primary teeth (HP:0006323)1.86802929
129Alveolar cell carcinoma (HP:0006519)1.86187430
130Milia (HP:0001056)1.85968681
131Reduced subcutaneous adipose tissue (HP:0003758)1.85958726
132Short clavicles (HP:0000894)1.85394855
133Abnormality of transition element cation homeostasis (HP:0011030)1.85330559
134Chondrocalcinosis (HP:0000934)1.84008145
135Elfin facies (HP:0004428)1.83783605
136Pulmonic stenosis (HP:0001642)1.83628166
137Reticulocytopenia (HP:0001896)1.82351108
138Difficulty climbing stairs (HP:0003551)1.80873251
139Pulmonary infiltrates (HP:0002113)1.80651826
140Abnormality of the gastric mucosa (HP:0004295)1.79604862
141Purpura (HP:0000979)1.79563967
142Cheilitis (HP:0100825)1.79171482
143Stomach cancer (HP:0012126)1.79052546
144Systemic lupus erythematosus (HP:0002725)1.79015035
145Congenital ichthyosiform erythroderma (HP:0007431)1.78903212
146Abnormality of Sharpey fibers (HP:0100685)1.78860383
147Disproportionate tall stature (HP:0001519)1.78822312
148Hemorrhage of the eye (HP:0011885)1.78220378
149Joint laxity (HP:0001388)1.77490732
150Right ventricular cardiomyopathy (HP:0011663)1.77073202
151Venous insufficiency (HP:0005293)1.76437426
152Vertebral compression fractures (HP:0002953)1.75784441
153Spinal rigidity (HP:0003306)1.75350615
154Muscle fiber splitting (HP:0003555)1.75145306
155Cavernous hemangioma (HP:0001048)1.74998316
156Bilateral sensorineural hearing impairment (HP:0008619)1.74849376
157Camptodactyly of toe (HP:0001836)1.74731967
158Venous abnormality (HP:0002624)1.74578536
159Acanthosis nigricans (HP:0000956)1.74396568
160Abnormality of mucopolysaccharide metabolism (HP:0011020)1.73381015
161Abnormality of polysaccharide metabolism (HP:0011012)1.73381015
162Abnormality of glycosaminoglycan metabolism (HP:0004371)1.73381015
163Hydroxyprolinuria (HP:0003080)1.73296605
164Abnormality of proline metabolism (HP:0010907)1.73296605
165Conjugated hyperbilirubinemia (HP:0002908)1.72890654
166Joint hemorrhage (HP:0005261)1.72604203
167Prostate neoplasm (HP:0100787)1.71790072
168Increased serum ferritin (HP:0003281)1.71746989
169Mucosal telangiectasiae (HP:0100579)1.68001974
170Ovoid vertebral bodies (HP:0003300)1.66902301
171Confusion (HP:0001289)1.66788048
172Intrahepatic cholestasis (HP:0001406)1.66387293
173Split foot (HP:0001839)1.65237172

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE15.86637315
2KDR4.03428433
3EPHA23.64743421
4MAP3K143.38624266
5EPHB23.13120803
6NUAK13.09222398
7IRAK33.02926356
8TGFBR22.55486240
9RIPK12.47532259
10TBK12.14802058
11MST42.13120674
12TESK12.01767818
13GRK11.94258858
14PDK21.92424376
15LIMK11.85522612
16PRKG21.84747802
17PBK1.83594251
18BCR1.77241470
19PIK3CG1.74890786
20TAOK31.69989978
21IKBKE1.64273134
22INSRR1.63589382
23AKT31.60503129
24PTK61.39002504
25NLK1.31175745
26TGFBR11.31007201
27EIF2AK31.30494496
28NTRK11.29665127
29MST1R1.29090948
30PTK2B1.26857306
31BMX1.26431422
32LMTK21.22819594
33STK101.21133198
34IKBKB1.20112944
35MAPK71.16240803
36TRPM71.16226462
37CDK81.16095854
38MAPKAPK31.14442190
39MYLK1.13387421
40TXK1.10384971
41PDGFRA1.10029951
42PIM21.08356844
43NEK91.07548029
44DMPK1.07264086
45EIF2AK21.03725795
46FGR1.02711073
47BMPR1B1.02480213
48FES0.97832206
49CSK0.95860589
50MAP3K120.95812240
51ROCK10.95058539
52PAK20.94616064
53MAP3K30.93720259
54ERN10.93015105
55CHUK0.92820099
56EIF2AK10.92536635
57PAK40.91801914
58TEC0.91473798
59MAP2K20.89819648
60STK30.86709511
61ILK0.86237016
62IRAK40.80870264
63PRKCE0.78964832
64NEK60.75773037
65GRK70.73612841
66FER0.73362924
67EPHB10.72748648
68ROCK20.69879184
69MAPK150.68724577
70MARK30.67869094
71PTK20.67570370
72STK390.67388687
73BMPR20.66555403
74ITK0.66392759
75MAP3K110.66133759
76ABL10.65523827
77MAP2K30.64828591
78BLK0.64822410
79JAK30.64663419
80MOS0.62224832
81STK240.61757463
82PDGFRB0.57748061
83IGF1R0.57459314
84PIK3CA0.53875168
85CDK90.53250259
86STK38L0.53125483
87EGFR0.52587892
88FGFR40.51366386
89IRAK10.50602603
90GSK3A0.50447946
91LRRK20.49740447
92INSR0.49390782
93DAPK30.47202814
94ERBB40.46375239
95LATS20.45456520
96ERBB30.45410042
97FLT30.44992479
98JAK10.44092933
99MAPK120.43834705
100MAP4K10.41750640
101PRKAA20.41377149
102LATS10.41329091
103TYK20.40163945
104CDK60.39240980
105MATK0.39181277
106ZAP700.39159951
107ABL20.38532625
108FRK0.38240369
109PIM10.34077255
110MAPKAPK50.33827236
111TLK10.33564599
112EPHA30.33263374
113PLK20.31026208
114MELK0.30950975
115MAP2K10.30585521
116PRKD10.30138174
117DAPK10.29518385
118MET0.29326361
119SIK30.29289491
120SRC0.28513854
121ADRBK20.27696967
122YES10.27583938
123TTN0.26941328
124TAOK20.25869784
125HCK0.25564259
126RPS6KB20.24475566
127LYN0.24457314
128MTOR0.24410392
129RPS6KA20.23635550
130PKN20.23237497
131PAK60.22056595
132FGFR10.21451737
133SCYL20.21186620
134SIK10.20884685
135ARAF0.19135458
136TSSK60.17832361
137SGK30.16298471
138MAP3K10.16029692
139CAMK1D0.16021907

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005313.01669911
2Graft-versus-host disease_Homo sapiens_hsa053322.83998886
3Rheumatoid arthritis_Homo sapiens_hsa053232.74323785
4Malaria_Homo sapiens_hsa051442.41981005
5NOD-like receptor signaling pathway_Homo sapiens_hsa046212.38088150
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.37071025
7Toll-like receptor signaling pathway_Homo sapiens_hsa046202.30517874
8Leishmaniasis_Homo sapiens_hsa051402.28262621
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.12410023
10Adherens junction_Homo sapiens_hsa045202.11941024
11* TNF signaling pathway_Homo sapiens_hsa046682.08962493
12Hematopoietic cell lineage_Homo sapiens_hsa046402.07807190
13Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.05129709
14Pertussis_Homo sapiens_hsa051332.04758273
15Sulfur metabolism_Homo sapiens_hsa009202.02598251
16Salmonella infection_Homo sapiens_hsa051322.02387291
17Leukocyte transendothelial migration_Homo sapiens_hsa046701.99194894
18Legionellosis_Homo sapiens_hsa051341.98918088
19African trypanosomiasis_Homo sapiens_hsa051431.92721749
20Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.89142827
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.83013802
22Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.79955521
23Allograft rejection_Homo sapiens_hsa053301.78025273
24Type I diabetes mellitus_Homo sapiens_hsa049401.75161305
25ECM-receptor interaction_Homo sapiens_hsa045121.62415618
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.60133473
27* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.58944525
28Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.56685805
29Osteoclast differentiation_Homo sapiens_hsa043801.53421445
30Staphylococcus aureus infection_Homo sapiens_hsa051501.43739958
31Tuberculosis_Homo sapiens_hsa051521.43211885
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.41979411
33Influenza A_Homo sapiens_hsa051641.41451838
34Asthma_Homo sapiens_hsa053101.37341432
35Galactose metabolism_Homo sapiens_hsa000521.37324156
36Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.36193198
37Amoebiasis_Homo sapiens_hsa051461.33330928
38Hepatitis C_Homo sapiens_hsa051601.29226426
39Focal adhesion_Homo sapiens_hsa045101.25236364
40Mineral absorption_Homo sapiens_hsa049781.21562079
41Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.19972098
42Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.19044351
43TGF-beta signaling pathway_Homo sapiens_hsa043501.15882969
44Toxoplasmosis_Homo sapiens_hsa051451.15645399
45Proteoglycans in cancer_Homo sapiens_hsa052051.15546285
46N-Glycan biosynthesis_Homo sapiens_hsa005101.13444557
47Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.12846684
48Small cell lung cancer_Homo sapiens_hsa052221.11577826
49Measles_Homo sapiens_hsa051621.10988876
50Pancreatic cancer_Homo sapiens_hsa052121.08395340
51Dorso-ventral axis formation_Homo sapiens_hsa043201.05606146
52Tight junction_Homo sapiens_hsa045301.04097037
53Apoptosis_Homo sapiens_hsa042101.02876371
54Endocytosis_Homo sapiens_hsa041441.00648123
55Rap1 signaling pathway_Homo sapiens_hsa040151.00040178
56Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.00025312
57Viral myocarditis_Homo sapiens_hsa054160.99603807
58Shigellosis_Homo sapiens_hsa051310.99019901
59Autoimmune thyroid disease_Homo sapiens_hsa053200.97887249
60Glutathione metabolism_Homo sapiens_hsa004800.97519363
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.96138143
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.95819546
63Vitamin digestion and absorption_Homo sapiens_hsa049770.95205136
64Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.94738164
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.91158731
66Thyroid cancer_Homo sapiens_hsa052160.87975648
67Notch signaling pathway_Homo sapiens_hsa043300.87799285
68Complement and coagulation cascades_Homo sapiens_hsa046100.87767847
69Chemokine signaling pathway_Homo sapiens_hsa040620.85692654
70Sphingolipid metabolism_Homo sapiens_hsa006000.85266126
71p53 signaling pathway_Homo sapiens_hsa041150.84986652
72MicroRNAs in cancer_Homo sapiens_hsa052060.84408084
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84300664
74Chronic myeloid leukemia_Homo sapiens_hsa052200.82786052
75Phagosome_Homo sapiens_hsa041450.82072545
76Hippo signaling pathway_Homo sapiens_hsa043900.80627211
77PI3K-Akt signaling pathway_Homo sapiens_hsa041510.80010372
78Basal cell carcinoma_Homo sapiens_hsa052170.79456535
79Jak-STAT signaling pathway_Homo sapiens_hsa046300.78771147
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.77642446
81Platelet activation_Homo sapiens_hsa046110.75357374
82Dilated cardiomyopathy_Homo sapiens_hsa054140.75270429
83Regulation of actin cytoskeleton_Homo sapiens_hsa048100.75097337
84Herpes simplex infection_Homo sapiens_hsa051680.74095270
85Pentose phosphate pathway_Homo sapiens_hsa000300.71291141
86Hepatitis B_Homo sapiens_hsa051610.70355923
87Selenocompound metabolism_Homo sapiens_hsa004500.68417545
88Pathways in cancer_Homo sapiens_hsa052000.66855354
89Ovarian steroidogenesis_Homo sapiens_hsa049130.65883028
90* HIF-1 signaling pathway_Homo sapiens_hsa040660.63231923
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62322682
92Ras signaling pathway_Homo sapiens_hsa040140.59736567
93Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57799700
94Protein digestion and absorption_Homo sapiens_hsa049740.56520614
95Hedgehog signaling pathway_Homo sapiens_hsa043400.56369832
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.55520791
97Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.54647134
98Axon guidance_Homo sapiens_hsa043600.52463420
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52384253
100HTLV-I infection_Homo sapiens_hsa051660.52224625
101Nitrogen metabolism_Homo sapiens_hsa009100.51436877
102FoxO signaling pathway_Homo sapiens_hsa040680.50616389
103Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.50472171
104Fructose and mannose metabolism_Homo sapiens_hsa000510.49590624
105Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49112706
106Renal cell carcinoma_Homo sapiens_hsa052110.47593610
107Lysosome_Homo sapiens_hsa041420.47050805
108Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45176112
109Phospholipase D signaling pathway_Homo sapiens_hsa040720.43350968
110VEGF signaling pathway_Homo sapiens_hsa043700.42087016
111Prostate cancer_Homo sapiens_hsa052150.40430518
112Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39603529
113Vibrio cholerae infection_Homo sapiens_hsa051100.39473153
114Other glycan degradation_Homo sapiens_hsa005110.37642219
115Prion diseases_Homo sapiens_hsa050200.35113805
116Arachidonic acid metabolism_Homo sapiens_hsa005900.34555223
117Pancreatic secretion_Homo sapiens_hsa049720.34308844
118Arginine biosynthesis_Homo sapiens_hsa002200.34059666
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.33685525
120MAPK signaling pathway_Homo sapiens_hsa040100.32625542
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32131257
122Bladder cancer_Homo sapiens_hsa052190.32123051
123Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.32064969
124Vascular smooth muscle contraction_Homo sapiens_hsa042700.31702147
125Protein export_Homo sapiens_hsa030600.30800837
126Estrogen signaling pathway_Homo sapiens_hsa049150.22460396
127ErbB signaling pathway_Homo sapiens_hsa040120.22033219
128Cyanoamino acid metabolism_Homo sapiens_hsa004600.21226281

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »