EDN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the endothelin protein family of secretory vasoconstrictive peptides. The preproprotein is processed to a short mature form which functions as a ligand for the endothelin receptors that initiate intracellular signaling events. This gene product is involved in a wide range of biological processes, such as hypertension and ovulation. Altered expression of this gene is implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1uronic acid metabolic process (GO:0006063)9.70660212
2glucuronate metabolic process (GO:0019585)9.70660212
3cellular glucuronidation (GO:0052695)8.77077391
4phosphate ion transmembrane transport (GO:0035435)7.81258871
5one-carbon compound transport (GO:0019755)7.43810770
6urate metabolic process (GO:0046415)6.76238632
7epoxygenase P450 pathway (GO:0019373)6.59529993
8polyol transport (GO:0015791)6.58729242
9phosphate ion transport (GO:0006817)6.54281771
10drug transmembrane transport (GO:0006855)6.29121758
11angiotensin maturation (GO:0002003)5.97034639
12diterpenoid biosynthetic process (GO:0016102)5.69049297
13benzene-containing compound metabolic process (GO:0042537)5.65078503
14glutathione derivative biosynthetic process (GO:1901687)5.64882943
15glutathione derivative metabolic process (GO:1901685)5.64882943
16regulation of skeletal muscle contraction (GO:0014819)5.55323013
17interferon-gamma secretion (GO:0072643)5.54842065
18toxin transport (GO:1901998)5.52587784
193-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)5.40965372
20purine ribonucleoside bisphosphate metabolic process (GO:0034035)5.40965372
21positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.17831723
22flavonoid metabolic process (GO:0009812)5.09334582
23drug transport (GO:0015893)5.08842543
24negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)4.99582100
25phenylpropanoid metabolic process (GO:0009698)4.97224244
26omega-hydroxylase P450 pathway (GO:0097267)4.92456051
27Notch signaling involved in heart development (GO:0061314)4.81634216
28type B pancreatic cell proliferation (GO:0044342)4.80237552
29renal absorption (GO:0070293)4.73555882
30cell differentiation involved in metanephros development (GO:0072202)4.68003382
31protein prenylation (GO:0018342)4.67076222
32prenylation (GO:0097354)4.67076222
33peptide catabolic process (GO:0043171)4.65174492
34L-ascorbic acid metabolic process (GO:0019852)4.62579397
35facial nerve structural organization (GO:0021612)4.56132409
36glutathione metabolic process (GO:0006749)4.47214408
37regulation of cardioblast proliferation (GO:0003264)4.44303921
38regulation of secondary heart field cardioblast proliferation (GO:0003266)4.44303921
39response to muramyl dipeptide (GO:0032495)4.40179464
40NADH metabolic process (GO:0006734)4.37287620
41intestinal absorption (GO:0050892)4.33400838
42regulation of apoptotic process involved in morphogenesis (GO:1902337)4.30077947
43glutathione biosynthetic process (GO:0006750)4.25821628
44hepatocyte differentiation (GO:0070365)4.22385423
45desmosome organization (GO:0002934)4.21155324
46sphingomyelin metabolic process (GO:0006684)4.17327138
47nonribosomal peptide biosynthetic process (GO:0019184)4.12935758
48regulation of chemokine secretion (GO:0090196)4.12432674
49regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.09950848
50auditory receptor cell differentiation (GO:0042491)4.09421885
51sulfation (GO:0051923)4.03415160
52vitamin D metabolic process (GO:0042359)3.91941817
53pharyngeal system development (GO:0060037)3.91180991
54regulation of guanylate cyclase activity (GO:0031282)3.91004349
55negative regulation of phosphoprotein phosphatase activity (GO:0032515)3.88358361
56toxin metabolic process (GO:0009404)3.87402819
57fructose metabolic process (GO:0006000)3.87400581
58relaxation of cardiac muscle (GO:0055119)3.85189068
59terpenoid biosynthetic process (GO:0016114)3.84786743
60interleukin-6-mediated signaling pathway (GO:0070102)3.84024200
61bone remodeling (GO:0046849)3.80853333
62GDP-mannose metabolic process (GO:0019673)3.76619881
63negative regulation of axon extension involved in axon guidance (GO:0048843)3.73951670
64hormone catabolic process (GO:0042447)3.70844918
65regulation of superoxide anion generation (GO:0032928)3.65629651
66positive regulation of pseudopodium assembly (GO:0031274)3.61069926
67maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.59285015
68regulation of germinal center formation (GO:0002634)3.59189863
69epithelial cell-cell adhesion (GO:0090136)3.58140298
70sulfur amino acid catabolic process (GO:0000098)3.57635045
71heart valve morphogenesis (GO:0003179)3.52207635
72* regulation of systemic arterial blood pressure by hormone (GO:0001990)3.50451687
73* regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.50451687
74* endocrine process (GO:0050886)3.50451687
75drug metabolic process (GO:0017144)3.49254941
76regulation of cholesterol biosynthetic process (GO:0045540)3.47767976
77phospholipid scrambling (GO:0017121)3.43608707
78relaxation of muscle (GO:0090075)3.43154422
79cardiac right ventricle morphogenesis (GO:0003215)3.38216181
80cellular response to interleukin-6 (GO:0071354)3.37148167
81outer ear morphogenesis (GO:0042473)3.35562442
82cranial nerve structural organization (GO:0021604)3.32579906
83protein retention in ER lumen (GO:0006621)3.32413392
84endocardial cushion morphogenesis (GO:0003203)3.32254699
85fat-soluble vitamin biosynthetic process (GO:0042362)3.32064718
86renal system process involved in regulation of blood volume (GO:0001977)3.27008507
87regulation of pseudopodium assembly (GO:0031272)3.24251947
88aorta morphogenesis (GO:0035909)3.21776331
89neurotransmitter biosynthetic process (GO:0042136)3.21647665
90regulation of vitamin metabolic process (GO:0030656)3.20775685
91regulation of interleukin-12 biosynthetic process (GO:0045075)3.20346290
92adhesion of symbiont to host (GO:0044406)3.19962097
93nucleotide transmembrane transport (GO:1901679)3.19644623
94nephron epithelium morphogenesis (GO:0072088)3.18523655
95nephron tubule morphogenesis (GO:0072078)3.18523655
96COPI coating of Golgi vesicle (GO:0048205)3.12613167
97Golgi transport vesicle coating (GO:0048200)3.12613167
98histamine transport (GO:0051608)3.11463200
99* regulation of systemic arterial blood pressure (GO:0003073)3.11443461
100polarized epithelial cell differentiation (GO:0030859)3.10191367
101phenol-containing compound catabolic process (GO:0019336)3.09667586
102establishment of epithelial cell polarity (GO:0090162)3.07986233
103response to caffeine (GO:0031000)3.06344288
104myeloid leukocyte mediated immunity (GO:0002444)3.06068321
105auditory receptor cell stereocilium organization (GO:0060088)3.04540858
106actin filament depolymerization (GO:0030042)3.02074916
107regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.01839937
108glomerulus development (GO:0032835)3.00080634
109O-glycan processing (GO:0016266)2.99780647
110inner ear receptor cell differentiation (GO:0060113)2.98630809
111relaxation of smooth muscle (GO:0044557)2.97730093
1124-hydroxyproline metabolic process (GO:0019471)2.96321259
113ganglion development (GO:0061548)2.96300974
114fat-soluble vitamin metabolic process (GO:0006775)2.95974664
115quaternary ammonium group transport (GO:0015697)2.95841707
116response to progesterone (GO:0032570)2.95520340
117negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.95046790
118calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.94739355
119negative regulation of axon guidance (GO:1902668)2.93723134
120peptide biosynthetic process (GO:0043043)2.92070929
121response to food (GO:0032094)2.91269279
122urea cycle (GO:0000050)2.90326183
123hydrogen peroxide biosynthetic process (GO:0050665)2.89099966
124muscle cell cellular homeostasis (GO:0046716)2.86777171
125positive regulation of response to oxidative stress (GO:1902884)2.86715866
126positive regulation of cellular response to oxidative stress (GO:1900409)2.86715866
127negative regulation of toll-like receptor signaling pathway (GO:0034122)2.86558535
128positive regulation of guanylate cyclase activity (GO:0031284)2.84345205
129morphogenesis of an epithelial sheet (GO:0002011)2.82841088
130axon extension involved in axon guidance (GO:0048846)2.82518561
131neuron projection extension involved in neuron projection guidance (GO:1902284)2.82518561
132regulation of water loss via skin (GO:0033561)2.82299694
133glycoside metabolic process (GO:0016137)2.80598702
134virion attachment to host cell (GO:0019062)2.80027236
135adhesion of symbiont to host cell (GO:0044650)2.80027236
136cell surface receptor signaling pathway involved in heart development (GO:0061311)2.78198514
137xenobiotic metabolic process (GO:0006805)2.77588151
138establishment of apical/basal cell polarity (GO:0035089)2.77103005
139glycosylceramide metabolic process (GO:0006677)2.77048007
140regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.76574401
141oligosaccharide biosynthetic process (GO:0009312)2.76505971
142macroautophagy (GO:0016236)2.76135513
143bundle of His cell to Purkinje myocyte communication (GO:0086069)2.75957933
144primary alcohol catabolic process (GO:0034310)2.75490605
145negative regulation of JUN kinase activity (GO:0043508)2.74828782
146regulation of bile acid biosynthetic process (GO:0070857)2.74140223
147response to interleukin-6 (GO:0070741)2.74115090
148surfactant homeostasis (GO:0043129)2.72894365
149amide biosynthetic process (GO:0043604)2.71874076
150positive regulation of interleukin-8 secretion (GO:2000484)2.70416567
151response to dietary excess (GO:0002021)2.69595850
152glycolipid catabolic process (GO:0019377)2.68830963
153urea metabolic process (GO:0019627)2.68714336
154mesenchyme morphogenesis (GO:0072132)2.68674876
155nucleotide-sugar biosynthetic process (GO:0009226)2.68444766
156glycosphingolipid catabolic process (GO:0046479)2.67681864
157neuronal stem cell maintenance (GO:0097150)2.66718924
158ear development (GO:0043583)2.66255110
159regulation of type B pancreatic cell apoptotic process (GO:2000674)2.65040966
160membrane lipid catabolic process (GO:0046466)2.64949237
161peptide hormone processing (GO:0016486)2.64115447
162peroxisome fission (GO:0016559)2.63719413
163membrane protein ectodomain proteolysis (GO:0006509)2.62928664
164negative regulation of chemokine production (GO:0032682)2.62798509
165ovulation cycle (GO:0042698)2.61972486
166negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.60980669
167cell adhesion mediated by integrin (GO:0033627)2.60335566
168sphingolipid catabolic process (GO:0030149)2.59663474
169multicellular organismal water homeostasis (GO:0050891)2.59368211
170polyketide metabolic process (GO:0030638)2.58866262
171doxorubicin metabolic process (GO:0044598)2.58866262
172daunorubicin metabolic process (GO:0044597)2.58866262
173hydrogen peroxide catabolic process (GO:0042744)2.57284771
174hemidesmosome assembly (GO:0031581)2.57240991
175negative regulation of metanephros development (GO:0072217)2.55056658
176establishment of skin barrier (GO:0061436)2.54083756
177copper ion transport (GO:0006825)2.53901633
178positive regulation of steroid biosynthetic process (GO:0010893)2.53459321
179negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.52690150
180reactive oxygen species biosynthetic process (GO:1903409)2.51503955
181tight junction assembly (GO:0070830)2.50762411
182xenobiotic catabolic process (GO:0042178)13.1491997
183response to nitrosative stress (GO:0051409)12.9929025

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human9.40046520
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.51167612
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.59830162
4SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.52630960
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.01718501
6ZNF263_19887448_ChIP-Seq_K562_Human2.84467854
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.83464453
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.66502420
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.39169488
10ESR1_21235772_ChIP-Seq_MCF-7_Human2.35551552
11CDX2_20551321_ChIP-Seq_CACO-2_Human2.22769835
12FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.21869506
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.06223200
14CLOCK_20551151_ChIP-Seq_293T_Human1.99438460
15ZNF217_24962896_ChIP-Seq_MCF-7_Human1.99245166
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.94022701
17LXR_22292898_ChIP-Seq_THP-1_Human1.89873730
18ESR2_21235772_ChIP-Seq_MCF-7_Human1.84108621
19AR_21572438_ChIP-Seq_LNCaP_Human1.80089708
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.77644796
21RARG_19884340_ChIP-ChIP_MEFs_Mouse1.76443079
22ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.67204030
23RXR_22108803_ChIP-Seq_LS180_Human1.67169939
24* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.65878388
25ATF3_27146783_Chip-Seq_COLON_Human1.64821337
26NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.62738386
27NRF2_20460467_ChIP-Seq_MEFs_Mouse1.62738386
28AHR_22903824_ChIP-Seq_MCF-7_Human1.59279164
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.57862788
30TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56540013
31ESR1_20079471_ChIP-ChIP_T-47D_Human1.50748814
32PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.50194785
33PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.49875978
34SOX9_24532713_ChIP-Seq_HFSC_Mouse1.47501863
35ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.46305318
36SMAD_19615063_ChIP-ChIP_OVARY_Human1.44799277
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43600732
38RXR_22158963_ChIP-Seq_LIVER_Mouse1.43319723
39CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.42921447
40* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.42753415
41ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.41677185
42TET1_21451524_ChIP-Seq_MESCs_Mouse1.39999720
43ELK3_25401928_ChIP-Seq_HUVEC_Human1.38050660
44* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.37223483
45SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.36612524
46SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.36612524
47KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.36458876
48WT1_19549856_ChIP-ChIP_CCG9911_Human1.35966966
49SOX2_20726797_ChIP-Seq_SW620_Human1.35062271
50STAT6_21828071_ChIP-Seq_BEAS2B_Human1.33499786
51PPARA_22158963_ChIP-Seq_LIVER_Mouse1.31131847
52CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29084234
53LXR_22158963_ChIP-Seq_LIVER_Mouse1.28135315
54* TP53_18474530_ChIP-ChIP_U2OS_Human1.27526594
55TP53_20018659_ChIP-ChIP_R1E_Mouse1.26668527
56AR_21909140_ChIP-Seq_LNCAP_Human1.26281145
57NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.26068866
58CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.25726428
59SOX2_27498859_Chip-Seq_STOMACH_Mouse1.23659904
60SOX2_18555785_ChIP-Seq_MESCs_Mouse1.22243381
61TCF3_18692474_ChIP-Seq_MEFs_Mouse1.19506870
62IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.19310025
63ESR1_15608294_ChIP-ChIP_MCF-7_Human1.18148284
64SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.14269894
65CJUN_26792858_Chip-Seq_BT549_Human1.14250960
66ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.14050997
67* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.13363259
68FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.11712904
69* GATA2_21666600_ChIP-Seq_HMVEC_Human1.11216238
70SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.10285217
71EZH2_18974828_ChIP-Seq_MESCs_Mouse1.09590700
72RNF2_18974828_ChIP-Seq_MESCs_Mouse1.09590700
73* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.09099781
74RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.08848107
75TCF4_18268006_ChIP-ChIP_LS174T_Human1.08108176
76* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.06824454
77NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.06220289
78SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.06170697
79KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.05359249
80EGR1_23403033_ChIP-Seq_LIVER_Mouse1.05302428
81SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03499105
82ARNT_22903824_ChIP-Seq_MCF-7_Human1.02573561
83ELF5_23300383_ChIP-Seq_T47D_Human1.02553398
84BCOR_27268052_Chip-Seq_Bcells_Human1.02117645
85* TP53_22127205_ChIP-Seq_IMR90_Human1.01470906
86EED_16625203_ChIP-ChIP_MESCs_Mouse1.01470474
87FOXM1_26456572_ChIP-Seq_MCF-7_Human1.01266546
88* RUNX1_27514584_Chip-Seq_MCF-7_Human1.00999261
89JARID2_20075857_ChIP-Seq_MESCs_Mouse0.99774445
90RING1B_27294783_Chip-Seq_ESCs_Mouse0.99076297
91SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.98667684
92TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97656502
93SUZ12_27294783_Chip-Seq_ESCs_Mouse0.97130347
94NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.96953583
95TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.96835799
96TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.96813069
97SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96400235
98* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.94788951
99SALL4_18804426_ChIP-ChIP_XEN_Mouse0.94405362
100HIF1A_21447827_ChIP-Seq_MCF-7_Human0.93798408
101RNF2_27304074_Chip-Seq_ESCs_Mouse0.93172296
102* CREB1_26743006_Chip-Seq_LNCaP_Human0.91915296
103RING1B_27294783_Chip-Seq_NPCs_Mouse0.91641590
104* EZH2_27294783_Chip-Seq_ESCs_Mouse0.90767907
105RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.90461740
106BMI1_23680149_ChIP-Seq_NPCS_Mouse0.90216402
107TP63_22573176_ChIP-Seq_HFKS_Human0.89539124
108* TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.89398121
109PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.89382517
110CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.89033977
111TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88351819
112* TP63_23658742_ChIP-Seq_EP156T_Human0.87998635
113GATA6_25053715_ChIP-Seq_YYC3_Human0.86726151
114SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.86661628
115BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.86520931
116FOXO3_23340844_ChIP-Seq_DLD1_Human0.85959262
117ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.85295336
118CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.84940144
119FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.84786719
120KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.83766565
121GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.83660461
122GATA1_22025678_ChIP-Seq_K562_Human0.83496474
123CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.82812538
124AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.82555580
125CTCF_27219007_Chip-Seq_ERYTHROID_Human0.82327934
126NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.82078518
127MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.81808897
128PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.81470625
129SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.81014593
130* RACK7_27058665_Chip-Seq_MCF-7_Human0.80489718
131CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.80305739
132NANOG_18555785_ChIP-Seq_MESCs_Mouse0.80132191
133* GATA3_24758297_ChIP-Seq_MCF-7_Human0.80084096
134ERG_21242973_ChIP-ChIP_JURKAT_Human0.79742849
135BCAT_22108803_ChIP-Seq_LS180_Human0.79163619
136FOXA1_25552417_ChIP-Seq_VCAP_Human0.77978162
137HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.77618843
138GF1_26923725_Chip-Seq_HPCs_Mouse0.75873555
139* KLF5_25053715_ChIP-Seq_YYC3_Human0.75301373
140SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.74941601
141UBF1/2_26484160_Chip-Seq_HMECs_Human0.74869225
142* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.73197853
143MTF2_20144788_ChIP-Seq_MESCs_Mouse0.72143394
144GATA4_25053715_ChIP-Seq_YYC3_Human0.72074659
145* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.71772711
146EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.71546585
147NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.71501772
148* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.70287044

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008789_abnormal_olfactory_epithelium6.17398445
2MP0005394_taste/olfaction_phenotype5.90787846
3MP0005499_abnormal_olfactory_system5.90787846
4MP0008875_abnormal_xenobiotic_pharmacok4.05002365
5MP0010234_abnormal_vibrissa_follicle3.78802714
6MP0009053_abnormal_anal_canal3.32535915
7MP0002132_abnormal_respiratory_system3.32367249
8MP0009840_abnormal_foam_cell3.13304438
9MP0002139_abnormal_hepatobiliary_system3.00246274
10MP0003453_abnormal_keratinocyte_physiol2.77422403
11MP0010030_abnormal_orbit_morphology2.76810981
12MP0005377_hearing/vestibular/ear_phenot2.58335596
13MP0003878_abnormal_ear_physiology2.58335596
14MP0001984_abnormal_olfaction2.57685106
15MP0004381_abnormal_hair_follicle2.56672320
16MP0002233_abnormal_nose_morphology2.54484585
17MP0003183_abnormal_peptide_metabolism2.53790564
18MP0003191_abnormal_cellular_cholesterol2.42744341
19MP0002877_abnormal_melanocyte_morpholog2.37789859
20MP0000566_synostosis2.19926700
21MP0002098_abnormal_vibrissa_morphology2.19282009
22MP0000762_abnormal_tongue_morphology2.16597790
23MP0000538_abnormal_urinary_bladder2.09233093
24MP0003186_abnormal_redox_activity2.02894042
25MP0000537_abnormal_urethra_morphology1.99692498
26MP0005332_abnormal_amino_acid1.95855251
27MP0005085_abnormal_gallbladder_physiolo1.95053344
28MP0000467_abnormal_esophagus_morphology1.87266859
29MP0002138_abnormal_hepatobiliary_system1.84198754
30MP0003806_abnormal_nucleotide_metabolis1.82243519
31MP0010155_abnormal_intestine_physiology1.77201948
32MP0004782_abnormal_surfactant_physiolog1.72998826
33MP0005451_abnormal_body_composition1.71211282
34MP0000013_abnormal_adipose_tissue1.70476764
35MP0009643_abnormal_urine_homeostasis1.70350532
36MP0004272_abnormal_basement_membrane1.68060132
37MP0002796_impaired_skin_barrier1.67818453
38MP0005187_abnormal_penis_morphology1.67007377
39MP0000678_abnormal_parathyroid_gland1.63224822
40MP0001664_abnormal_digestion1.61851361
41MP0001765_abnormal_ion_homeostasis1.60760189
42MP0000049_abnormal_middle_ear1.57686872
43MP0001501_abnormal_sleep_pattern1.56154531
44MP0009379_abnormal_foot_pigmentation1.55682023
45MP0010386_abnormal_urinary_bladder1.54013449
46MP0002060_abnormal_skin_morphology1.53336011
47MP0003252_abnormal_bile_duct1.51359915
48MP0003941_abnormal_skin_development1.49615245
49MP0000490_abnormal_crypts_of1.44495542
50MP0008872_abnormal_physiological_respon1.43974948
51MP0009250_abnormal_appendicular_skeleto1.41685378
52MP0003136_yellow_coat_color1.41613972
53MP0004510_myositis1.36538947
54MP0001851_eye_inflammation1.36321957
55MP0000377_abnormal_hair_follicle1.35824188
56MP0003566_abnormal_cell_adhesion1.35264213
57MP0002136_abnormal_kidney_physiology1.34012081
58MP0010678_abnormal_skin_adnexa1.32004970
59MP0000465_gastrointestinal_hemorrhage1.30439516
60MP0002249_abnormal_larynx_morphology1.30074349
61MP0000477_abnormal_intestine_morphology1.28122246
62MP0006292_abnormal_olfactory_placode1.28024884
63MP0002928_abnormal_bile_duct1.27255952
64MP0002166_altered_tumor_susceptibility1.24197056
65MP0001873_stomach_inflammation1.21561974
66MP0003866_abnormal_defecation1.21412223
67MP0005360_urolithiasis1.20240990
68MP0000003_abnormal_adipose_tissue1.19680273
69MP0004947_skin_inflammation1.16532208
70MP0002090_abnormal_vision1.15847659
71MP0005670_abnormal_white_adipose1.13280918
72MP0005166_decreased_susceptibility_to1.10111760
73MP0005084_abnormal_gallbladder_morpholo1.09814901
74MP0001216_abnormal_epidermal_layer1.08496609
75MP0005365_abnormal_bile_salt1.08473225
76MP0008260_abnormal_autophagy1.08159026
77MP0000613_abnormal_salivary_gland1.07729318
78MP0005636_abnormal_mineral_homeostasis1.06677288
79MP0000534_abnormal_ureter_morphology1.06617623
80MP0003868_abnormal_feces_composition1.05110058
81MP0001346_abnormal_lacrimal_gland1.04161761
82MP0002234_abnormal_pharynx_morphology1.03002725
83MP0003879_abnormal_hair_cell1.02305034
84MP0003693_abnormal_embryo_hatching1.01778319
85MP0004147_increased_porphyrin_level1.01052568
86MP0002277_abnormal_respiratory_mucosa0.96552730
87MP0003943_abnormal_hepatobiliary_system0.96191662
88MP0001756_abnormal_urination0.96098660
89MP0005501_abnormal_skin_physiology0.94746736
90MP0005319_abnormal_enzyme/_coenzyme0.94377843
91MP0004858_abnormal_nervous_system0.93893110
92MP0001881_abnormal_mammary_gland0.92849458
93MP0004043_abnormal_pH_regulation0.92829049
94MP0002177_abnormal_outer_ear0.91773534
95MP0002006_tumorigenesis0.91620141
96MP0000609_abnormal_liver_physiology0.91398307
97MP0005408_hypopigmentation0.91079653
98MP0009785_altered_susceptibility_to0.89270887
99MP0001905_abnormal_dopamine_level0.88186145
100MP0001177_atelectasis0.87184543
101MP0005330_cardiomyopathy0.86745478
102MP0005197_abnormal_uvea_morphology0.85515806
103MP0003755_abnormal_palate_morphology0.85037508
104MP0003300_gastrointestinal_ulcer0.83386953
105MP0003315_abnormal_perineum_morphology0.81607855
106MP0000627_abnormal_mammary_gland0.80104738
107MP0005409_darkened_coat_color0.79830238
108MP0002295_abnormal_pulmonary_circulatio0.79653309
109MP0006082_CNS_inflammation0.79497640
110MP0003937_abnormal_limbs/digits/tail_de0.78689204
111MP0003942_abnormal_urinary_system0.78107007
112MP0003718_maternal_effect0.77411853
113MP0010329_abnormal_lipoprotein_level0.77244287
114MP0003436_decreased_susceptibility_to0.76590934
115MP0001853_heart_inflammation0.76133195
116MP0009780_abnormal_chondrocyte_physiolo0.75938020
117MP0002118_abnormal_lipid_homeostasis0.75380322
118MP0000383_abnormal_hair_follicle0.75323305
119MP0001340_abnormal_eyelid_morphology0.74826756
120MP0010771_integument_phenotype0.74626340
121MP0003724_increased_susceptibility_to0.74555286
122MP0002254_reproductive_system_inflammat0.74322750
123MP0002133_abnormal_respiratory_system0.71572188
124MP0005388_respiratory_system_phenotype0.71572188
125MP0003690_abnormal_glial_cell0.70324040
126MP0005164_abnormal_response_to0.70233208
127MP0005023_abnormal_wound_healing0.69788400
128MP0004264_abnormal_extraembryonic_tissu0.69524500
129MP0003385_abnormal_body_wall0.68847750
130MP0005375_adipose_tissue_phenotype0.67535700
131MP0003938_abnormal_ear_development0.67521465
132MP0003828_pulmonary_edema0.66849289
133MP0006138_congestive_heart_failure0.66639109
134MP0004134_abnormal_chest_morphology0.65775166
135MP0009765_abnormal_xenobiotic_induced0.65145515
136MP0002896_abnormal_bone_mineralization0.64833350
137MP0005076_abnormal_cell_differentiation0.64397800
138MP0001764_abnormal_homeostasis0.64125310
139MP0000163_abnormal_cartilage_morphology0.63611869
140MP0010352_gastrointestinal_tract_polyps0.62552128
141MP0001919_abnormal_reproductive_system0.62431728
142MP0002009_preneoplasia0.61747725
143MP0003091_abnormal_cell_migration0.59520970
144MP0005165_increased_susceptibility_to0.59347476
145MP0000372_irregular_coat_pigmentation0.59247387
146MP0001666_abnormal_nutrient_absorption0.59071337
147MP0002653_abnormal_ependyma_morphology0.59008691
148MP0003705_abnormal_hypodermis_morpholog0.58667183
149MP0005584_abnormal_enzyme/coenzyme_acti0.58172217
150MP0009764_decreased_sensitivity_to0.57729686
151MP0000462_abnormal_digestive_system0.57302176
152MP0002092_abnormal_eye_morphology0.57254652
153MP0000579_abnormal_nail_morphology0.56938672
154MP0009931_abnormal_skin_appearance0.56928859
155MP0005248_abnormal_Harderian_gland0.56301311
156MP0002135_abnormal_kidney_morphology0.55953479
157MP0005508_abnormal_skeleton_morphology0.55309569
158MP0000858_altered_metastatic_potential0.55269020
159MP0008438_abnormal_cutaneous_collagen0.53597915
160MP0004019_abnormal_vitamin_homeostasis0.53588062
161MP0005381_digestive/alimentary_phenotyp0.53359754

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glutamine family amino acid metabolism (HP:0010902)8.75431222
2Stomach cancer (HP:0012126)8.37868615
3Hydroxyprolinuria (HP:0003080)6.96821322
4Abnormality of proline metabolism (HP:0010907)6.96821322
5Lip pit (HP:0100267)6.40389442
6Prostate neoplasm (HP:0100787)5.85941165
7Malnutrition (HP:0004395)5.78853986
8Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)4.78342740
9Vascular calcification (HP:0004934)4.51309782
10Popliteal pterygium (HP:0009756)4.44325318
11Renal tubular acidosis (HP:0001947)4.38305678
12Bifid scrotum (HP:0000048)4.34689840
13Alopecia of scalp (HP:0002293)4.20994232
14Abnormal hemoglobin (HP:0011902)4.17741072
15Aplasia involving bones of the upper limbs (HP:0009823)4.16149209
16Aplasia of the phalanges of the hand (HP:0009802)4.16149209
17Aplasia involving bones of the extremities (HP:0009825)4.16149209
18Cardiovascular calcification (HP:0011915)4.08281091
19Hyperphosphatemia (HP:0002905)4.06576510
20Abnormality of monocarboxylic acid metabolism (HP:0010996)3.90987634
21Stenosis of the external auditory canal (HP:0000402)3.82551835
22Steatorrhea (HP:0002570)3.80706097
23Alveolar cell carcinoma (HP:0006519)3.74361266
24Preauricular pit (HP:0004467)3.57953090
25Periauricular skin pits (HP:0100277)3.57953090
26Chorioretinal atrophy (HP:0000533)3.56201766
27Abnormality of the distal phalanges of the toes (HP:0010182)3.54873383
28Hypoplastic labia majora (HP:0000059)3.53015031
29Fat malabsorption (HP:0002630)3.49947924
30Abnormality of the phalanges of the 2nd finger (HP:0009541)3.48552087
31Neoplasm of the tracheobronchial system (HP:0100552)3.42242372
32Tetraparesis (HP:0002273)3.32399624
33Absent eyebrow (HP:0002223)3.28360483
34Ileus (HP:0002595)3.23889774
35Vertebral compression fractures (HP:0002953)3.23676484
36Abnormality of the labia majora (HP:0012881)3.20887502
37Thin bony cortex (HP:0002753)3.16666117
38Focal segmental glomerulosclerosis (HP:0000097)3.14256769
39Abnormality of the middle phalanges of the toes (HP:0010183)3.11262260
40Hypoplastic scapulae (HP:0000882)3.10829181
41Aplasia/Hypoplasia of the scapulae (HP:0006713)3.10829181
42Skin pits (HP:0100276)3.01075499
43Hypoplasia of the uterus (HP:0000013)3.00224734
44Degeneration of the lateral corticospinal tracts (HP:0002314)2.98586885
45Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.98586885
46Distal lower limb muscle weakness (HP:0009053)2.92212260
47Abdominal distention (HP:0003270)2.89012158
48Confusion (HP:0001289)2.87759536
49Right ventricular cardiomyopathy (HP:0011663)2.84553583
50Potter facies (HP:0002009)2.75752702
51Facial shape deformation (HP:0011334)2.75752702
52Rickets (HP:0002748)2.72014202
53Short hallux (HP:0010109)2.71000950
54Pulmonary artery stenosis (HP:0004415)2.70847433
55Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.64007009
56Hypoplasia of dental enamel (HP:0006297)2.62599723
57Chronic diarrhea (HP:0002028)2.62446516
58Morphological abnormality of the middle ear (HP:0008609)2.62406922
59Labial hypoplasia (HP:0000066)2.61749415
60Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.61464538
61Fibular aplasia (HP:0002990)2.61440522
62Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.59546472
63Renal dysplasia (HP:0000110)2.57044458
64Cupped ear (HP:0000378)2.56309196
65Pterygium (HP:0001059)2.53197405
66Ulnar claw (HP:0001178)2.51494065
67Villous atrophy (HP:0011473)2.50678998
68Abnormality of small intestinal villus morphology (HP:0011472)2.50678998
69Sleep apnea (HP:0010535)2.49750799
70Gout (HP:0001997)2.49366110
71Abnormal tarsal ossification (HP:0008369)2.48490759
72Abnormality of the prostate (HP:0008775)2.48205858
73Papillary thyroid carcinoma (HP:0002895)2.47897399
74Hyperammonemia (HP:0001987)2.45664471
75Dysphonia (HP:0001618)2.44669964
76Aplasia/hypoplasia of the uterus (HP:0008684)2.44554708
77Glomerulosclerosis (HP:0000096)2.44347986
78Abnormality of the vitamin B12 metabolism (HP:0004341)2.42901599
79Palpitations (HP:0001962)2.40211924
80Hypoplastic female external genitalia (HP:0012815)2.39871965
81Abnormality of urine glucose concentration (HP:0011016)2.37785479
82Glycosuria (HP:0003076)2.37785479
83Aplasia/Hypoplasia of the hallux (HP:0008362)2.37637986
84Down-sloping shoulders (HP:0200021)2.36635172
85Abnormality of aspartate family amino acid metabolism (HP:0010899)2.36549553
86Nasolacrimal duct obstruction (HP:0000579)2.35438273
87Pigmentary retinal degeneration (HP:0001146)2.35371252
88Sparse eyelashes (HP:0000653)2.34639432
89Renal tubular dysfunction (HP:0000124)2.33759814
90Systemic lupus erythematosus (HP:0002725)2.33750039
91Abnormality of the 2nd finger (HP:0004100)2.33628429
92Congenital ichthyosiform erythroderma (HP:0007431)2.29788013
93Absent eyelashes (HP:0000561)2.28368882
94Nephrolithiasis (HP:0000787)2.28072512
95Abnormality of the proximal phalanges of the hand (HP:0009834)2.27974444
96Proximal tubulopathy (HP:0000114)2.27710370
97Prolonged neonatal jaundice (HP:0006579)2.27695607
98Widely patent fontanelles and sutures (HP:0004492)2.26837381
99Reduced antithrombin III activity (HP:0001976)2.26177604
100Abnormality of cochlea (HP:0000375)2.25158816
101Hypoplasia of the ulna (HP:0003022)2.24552455
102Upper limb amyotrophy (HP:0009129)2.24452612
103Distal upper limb amyotrophy (HP:0007149)2.24452612
104Progressive sensorineural hearing impairment (HP:0000408)2.23456697
105Flat acetabular roof (HP:0003180)2.22926385
106Segmental peripheral demyelination/remyelination (HP:0003481)2.22914580
107Abnormality of the phalanges of the 5th finger (HP:0004213)2.22097184
108Taurodontia (HP:0000679)2.21348331
109Abnormality of permanent molar morphology (HP:0011071)2.21348331
110Abnormality of the dental root (HP:0006486)2.21348331
111Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.21220248
112Increased purine levels (HP:0004368)2.18709319
113Hyperuricemia (HP:0002149)2.18709319
114Xanthomatosis (HP:0000991)2.18436297
115Hypobetalipoproteinemia (HP:0003563)2.17347568
116Upper limb muscle weakness (HP:0003484)2.16609092
117Abnormality of alkaline phosphatase activity (HP:0004379)2.16530274
118Abnormality of vitamin B metabolism (HP:0004340)2.16508120
119Abnormal enzyme/coenzyme activity (HP:0012379)2.16186281
120Absent toe (HP:0010760)2.15078906
121Vertebral arch anomaly (HP:0008438)2.14784323
122Paraparesis (HP:0002385)2.14364669
123Ridged nail (HP:0001807)2.11437697
124Hepatocellular carcinoma (HP:0001402)2.10075639
125Dicarboxylic aciduria (HP:0003215)2.09071895
126Abnormality of dicarboxylic acid metabolism (HP:0010995)2.09071895
127Abnormality of fatty-acid metabolism (HP:0004359)2.07191095
128Abnormality of the renal collecting system (HP:0004742)2.06640589
129Hand muscle atrophy (HP:0009130)2.05183498
130Hepatoblastoma (HP:0002884)2.04837429
131Abnormality of molar (HP:0011077)2.04666765
132Abnormality of molar morphology (HP:0011070)2.04666765
133Corneal erosion (HP:0200020)2.04393497
134Abnormality of aromatic amino acid family metabolism (HP:0004338)2.03956680
135Split foot (HP:0001839)2.03754880
136Nausea (HP:0002018)2.02999836
137Hyperparathyroidism (HP:0000843)2.00608064
138Abnormality of vitamin metabolism (HP:0100508)1.99911772
139Plantar hyperkeratosis (HP:0007556)1.98406378
140Abnormality of the corticospinal tract (HP:0002492)1.98166935
141Congenital, generalized hypertrichosis (HP:0004540)1.97886753
142Gastrointestinal dysmotility (HP:0002579)1.96959446
143Abnormality of the labia (HP:0000058)1.96943516
144Neoplasm of the adrenal cortex (HP:0100641)1.94317335
145Hyperglycinuria (HP:0003108)1.92896140
146Ventricular tachycardia (HP:0004756)1.92771401
147Asymmetric septal hypertrophy (HP:0001670)1.90919090
148Pseudobulbar signs (HP:0002200)1.89909502
149Follicular hyperkeratosis (HP:0007502)1.88461281
150Cupped ribs (HP:0000887)1.88293759
151Mixed hearing impairment (HP:0000410)1.87574650
152Anterior segment dysgenesis (HP:0007700)1.87292364
153Morphological abnormality of the inner ear (HP:0011390)1.87116292
154Abnormality of the dental pulp (HP:0006479)1.86828956
155Aplasia/Hypoplasia of the ulna (HP:0006495)1.86082243
156Bone pain (HP:0002653)1.85476780
157Abnormality of the lacrimal duct (HP:0011481)1.85313735
158Elevated alkaline phosphatase (HP:0003155)1.83886847
159Acanthosis nigricans (HP:0000956)1.83247494
160Subcapsular cataract (HP:0000523)1.83094867
161Abnormality of the anterior horn cell (HP:0006802)1.82897610
162Degeneration of anterior horn cells (HP:0002398)1.82897610
163Milia (HP:0001056)1.82717334
164Wide cranial sutures (HP:0010537)1.81498782
165Nephritis (HP:0000123)1.81314661
166Pruritus (HP:0000989)1.81057705
167Abnormal glucose tolerance (HP:0001952)1.80482100
168Micronodular cirrhosis (HP:0001413)1.78540790
169Woolly hair (HP:0002224)1.78452507
170Spinal rigidity (HP:0003306)1.78152406
171Vertebral hypoplasia (HP:0008417)1.77687729
172Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.77687729
173Abnormality of macular pigmentation (HP:0008002)1.77382931
174Axonal loss (HP:0003447)1.77289737
175Mucopolysacchariduria (HP:0008155)1.77125795
176Urinary glycosaminoglycan excretion (HP:0003541)1.77125795
177Hyperactive renin-angiotensin system (HP:0000841)1.74032850
178Hypophosphatemia (HP:0002148)1.73826156
179Hypotrichosis (HP:0001006)1.73763934
180Abnormality of renal resorption (HP:0011038)1.70767516
181Abnormal hair laboratory examination (HP:0003328)1.69974868
182Increased CSF protein (HP:0002922)1.69757117
183Abnormality of nail color (HP:0100643)1.69398864
184Abnormal trabecular bone morphology (HP:0100671)1.69171177
185Pili torti (HP:0003777)1.68657194
186Abnormal urine phosphate concentration (HP:0012599)1.66769195

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K35.53945528
2MAP2K33.72240232
3MAP3K23.39460279
4MAP3K143.30374780
5RPS6KA43.23797018
6MST43.11863035
7MAPK152.91464117
8RPS6KB22.64411067
9ZAK2.55705213
10MAP2K62.21687313
11PBK2.11295701
12EPHA22.07809036
13ERBB32.07523007
14BCKDK2.03284643
15FRK2.02466424
16MYLK2.02064868
17SMG11.99768415
18TESK11.91109613
19FER1.91025333
20GRK61.85215785
21MAP3K111.82684939
22RIPK11.77204891
23MAP2K41.71918535
24LATS11.66666272
25NME11.62172833
26MAP2K21.60858021
27MET1.58975078
28ACVR1B1.56415680
29TNIK1.55917959
30MAP3K61.55563337
31EPHB21.52013826
32TAOK21.50354100
33EPHA31.50208759
34IKBKE1.47474772
35SIK31.47288452
36PAK41.44775821
37TAOK11.42271426
38MKNK21.41007358
39BMPR21.38932100
40NEK61.30578700
41TRPM71.29590896
42NLK1.27701135
43STK41.23823971
44IRAK31.22758264
45HIPK21.22638000
46DAPK11.18918563
47PDK21.16726694
48PTK21.15928387
49ADRBK21.13816771
50STK381.10541388
51EPHB11.10478782
52VRK21.06367282
53SIK11.05347585
54LIMK11.02786143
55ABL21.00960589
56PIM20.98584275
57MAP2K10.98024889
58MAPKAPK30.97224290
59MAPK120.95012153
60PRPF4B0.92344288
61BCR0.92175253
62TRIB30.89174010
63CAMK40.88872368
64MAPK70.87258873
65ILK0.86893266
66IKBKB0.86857845
67CSNK1A1L0.86151353
68NEK10.84929769
69TBK10.84884990
70MAP3K120.83163774
71CHUK0.82741812
72DAPK30.81350541
73TTN0.79934235
74MST1R0.76502499
75TESK20.75280402
76MKNK10.73344758
77PRKD20.72914915
78RPS6KA50.70862432
79LRRK20.70494267
80CDK30.68767834
81PRKCI0.66661100
82PAK30.65320266
83ERBB40.64245483
84DDR20.61065040
85PDPK10.60564049
86RPS6KA60.59266207
87STK100.59013666
88NME20.57752439
89YES10.56774806
90BMX0.56376650
91MAP3K50.56275063
92PRKG20.53832545
93MAP3K10.53103991
94RIPK40.52886765
95PRKCE0.52410814
96CDK60.51796327
97MAP3K80.51079485
98MAPKAPK50.50027023
99LMTK20.49484397
100AKT20.49473598
101GRK50.49296186
102CLK10.49048191
103CDC42BPA0.48624120
104TAF10.48407914
105IRAK20.48137529
106ERN10.46950780
107CAMK2B0.45414453
108ARAF0.45344387
109MAP3K100.44155779
110CAMK2D0.43724565
111EIF2AK10.43083001
112TYK20.42911150
113TRIM280.42002257
114PINK10.41701304
115CAMK10.40955244
116MAPKAPK20.40155659
117IRAK10.40042875
118PIK3CA0.39261607
119MAP3K40.39134597
120CDK40.39011897
121LATS20.37863650
122PIM10.37727265
123MATK0.36889928
124SRC0.35867405
125ERBB20.34760424
126RPS6KA20.34260262
127PRKCQ0.34046884
128FGFR40.33300553
129AURKA0.33263307
130CSNK1G30.32739012
131CDK90.32155922
132ROCK10.31502025
133PDGFRA0.31484616
134CDK70.31275755
135CAMK2G0.30989478
136MAP3K70.30055679
137STK38L0.29886611
138PRKCA0.29703431
139MAP3K130.26476007
140CSNK1A10.26318936
141ALK0.26210158
142VRK10.26168284
143CSNK1G10.25793516
144GSK3A0.24907513
145SGK4940.24078104
146SGK2230.24078104
147PRKCZ0.21780965
148PTK60.20626648
149STK240.19769186
150GRK10.18065496

Predicted pathways (KEGG)

RankGene SetZ-score
1Pentose and glucuronate interconversions_Homo sapiens_hsa000406.22795457
2Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009805.50604447
3Cyanoamino acid metabolism_Homo sapiens_hsa004605.21515872
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000535.19456177
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009824.98499894
6Chemical carcinogenesis_Homo sapiens_hsa052044.87232318
7Sulfur metabolism_Homo sapiens_hsa009204.38370712
8Steroid hormone biosynthesis_Homo sapiens_hsa001403.22962223
9Vitamin digestion and absorption_Homo sapiens_hsa049773.18213964
10Fructose and mannose metabolism_Homo sapiens_hsa000512.73038022
11Glutathione metabolism_Homo sapiens_hsa004802.67737208
12Renin-angiotensin system_Homo sapiens_hsa046142.52258211
13Fat digestion and absorption_Homo sapiens_hsa049752.52078572
14Drug metabolism - other enzymes_Homo sapiens_hsa009832.44602878
15Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.22934558
16Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.22332366
17Sulfur relay system_Homo sapiens_hsa041222.14556127
18Retinol metabolism_Homo sapiens_hsa008302.12594830
19Starch and sucrose metabolism_Homo sapiens_hsa005002.05379231
20Arginine biosynthesis_Homo sapiens_hsa002201.83497627
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.74816869
22Protein digestion and absorption_Homo sapiens_hsa049741.68478094
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.43387467
24Tryptophan metabolism_Homo sapiens_hsa003801.43043318
25Sphingolipid metabolism_Homo sapiens_hsa006001.42809566
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.39850424
27Fatty acid degradation_Homo sapiens_hsa000711.34855088
28Circadian rhythm_Homo sapiens_hsa047101.21108072
29Other glycan degradation_Homo sapiens_hsa005111.14479009
30Caffeine metabolism_Homo sapiens_hsa002321.14186085
31Galactose metabolism_Homo sapiens_hsa000521.13813367
32Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.09965077
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.07011748
34Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.03836441
35N-Glycan biosynthesis_Homo sapiens_hsa005101.01594825
36Primary bile acid biosynthesis_Homo sapiens_hsa001200.99361771
37Glycosaminoglycan degradation_Homo sapiens_hsa005310.95155828
38Glycerolipid metabolism_Homo sapiens_hsa005610.92641321
39Carbohydrate digestion and absorption_Homo sapiens_hsa049730.84613615
40TNF signaling pathway_Homo sapiens_hsa046680.82466518
41Mineral absorption_Homo sapiens_hsa049780.82250920
42Prolactin signaling pathway_Homo sapiens_hsa049170.79655484
43Collecting duct acid secretion_Homo sapiens_hsa049660.79088125
44Intestinal immune network for IgA production_Homo sapiens_hsa046720.76030264
45NOD-like receptor signaling pathway_Homo sapiens_hsa046210.75389602
46Rheumatoid arthritis_Homo sapiens_hsa053230.75024554
47Pertussis_Homo sapiens_hsa051330.74549973
48Bladder cancer_Homo sapiens_hsa052190.71220354
49Biosynthesis of amino acids_Homo sapiens_hsa012300.71164813
50Histidine metabolism_Homo sapiens_hsa003400.71073178
51Ovarian steroidogenesis_Homo sapiens_hsa049130.69481701
52Peroxisome_Homo sapiens_hsa041460.69206496
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68130890
54beta-Alanine metabolism_Homo sapiens_hsa004100.66210183
55Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63485379
56Bile secretion_Homo sapiens_hsa049760.62928232
57African trypanosomiasis_Homo sapiens_hsa051430.62790235
58Carbon metabolism_Homo sapiens_hsa012000.61941444
59Maturity onset diabetes of the young_Homo sapiens_hsa049500.61476830
60Linoleic acid metabolism_Homo sapiens_hsa005910.61213410
61Proteasome_Homo sapiens_hsa030500.60891976
62RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.60381400
63Cysteine and methionine metabolism_Homo sapiens_hsa002700.60112046
64Phenylalanine metabolism_Homo sapiens_hsa003600.56673509
65Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.55670573
66Prion diseases_Homo sapiens_hsa050200.53870914
67alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53641894
68Hepatitis C_Homo sapiens_hsa051600.53279440
69Cocaine addiction_Homo sapiens_hsa050300.52294066
70Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.48489168
71Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47733460
72Gastric acid secretion_Homo sapiens_hsa049710.47495130
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46694767
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.46490834
75Glycerophospholipid metabolism_Homo sapiens_hsa005640.46304121
76Fatty acid metabolism_Homo sapiens_hsa012120.45564945
77Ether lipid metabolism_Homo sapiens_hsa005650.45530624
78Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.43932122
79Metabolic pathways_Homo sapiens_hsa011000.43472997
80Toll-like receptor signaling pathway_Homo sapiens_hsa046200.43305234
81Fatty acid elongation_Homo sapiens_hsa000620.43271003
82Vibrio cholerae infection_Homo sapiens_hsa051100.42380783
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42081964
84ABC transporters_Homo sapiens_hsa020100.42075746
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41063370
86Type II diabetes mellitus_Homo sapiens_hsa049300.40018933
87Tight junction_Homo sapiens_hsa045300.38507693
88Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.38501408
89Salmonella infection_Homo sapiens_hsa051320.37754425
90Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.37040737
91Nitrogen metabolism_Homo sapiens_hsa009100.35996383
92Acute myeloid leukemia_Homo sapiens_hsa052210.34812205
93Pyruvate metabolism_Homo sapiens_hsa006200.34740528
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34061938
95Butanoate metabolism_Homo sapiens_hsa006500.33919149
96Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.33435645
97Leukocyte transendothelial migration_Homo sapiens_hsa046700.32517943
98Ribosome_Homo sapiens_hsa030100.31310127
99Adherens junction_Homo sapiens_hsa045200.30278430
100Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.30093290
101Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.29868895
102Osteoclast differentiation_Homo sapiens_hsa043800.29575051
103Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.28792558
104Legionellosis_Homo sapiens_hsa051340.28743396
105Graft-versus-host disease_Homo sapiens_hsa053320.27992855
106Folate biosynthesis_Homo sapiens_hsa007900.27544111
107Leishmaniasis_Homo sapiens_hsa051400.25443823
108Hippo signaling pathway_Homo sapiens_hsa043900.25298519
109Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.25165180
110Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.24212474
111Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.23475913
112AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.22901737
113Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.21769967
114Amoebiasis_Homo sapiens_hsa051460.21584061
115Adipocytokine signaling pathway_Homo sapiens_hsa049200.21491776
116Prostate cancer_Homo sapiens_hsa052150.20578614
117Lysosome_Homo sapiens_hsa041420.19145756
118Toxoplasmosis_Homo sapiens_hsa051450.19080654
119Basal cell carcinoma_Homo sapiens_hsa052170.19032995
120Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.16584765
121Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.16396854
122Influenza A_Homo sapiens_hsa051640.16205888
123Arginine and proline metabolism_Homo sapiens_hsa003300.15993174
124Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.15946009
125ECM-receptor interaction_Homo sapiens_hsa045120.15254300
126NF-kappa B signaling pathway_Homo sapiens_hsa040640.14723105
127B cell receptor signaling pathway_Homo sapiens_hsa046620.14705111
128Thyroid cancer_Homo sapiens_hsa052160.14647650
129Insulin resistance_Homo sapiens_hsa049310.14247760
130Arachidonic acid metabolism_Homo sapiens_hsa005900.14200413
131Fatty acid biosynthesis_Homo sapiens_hsa000610.13858495
132Tyrosine metabolism_Homo sapiens_hsa003500.13658298
133Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.13140368
134Amphetamine addiction_Homo sapiens_hsa050310.12867709
135Axon guidance_Homo sapiens_hsa043600.11486518
136Phototransduction_Homo sapiens_hsa047440.11458785
137HTLV-I infection_Homo sapiens_hsa051660.10292655
138T cell receptor signaling pathway_Homo sapiens_hsa046600.10226695
139TGF-beta signaling pathway_Homo sapiens_hsa043500.10200871
140Pentose phosphate pathway_Homo sapiens_hsa000300.10069393
141Glucagon signaling pathway_Homo sapiens_hsa049220.09905379
142Oxidative phosphorylation_Homo sapiens_hsa001900.09778633
143FoxO signaling pathway_Homo sapiens_hsa040680.09592615
144PPAR signaling pathway_Homo sapiens_hsa033200.09399703
145Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.07902440
146HIF-1 signaling pathway_Homo sapiens_hsa040660.06524854
147Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.06493853
148Central carbon metabolism in cancer_Homo sapiens_hsa052300.06397374
149Pancreatic secretion_Homo sapiens_hsa049720.06071009
150AMPK signaling pathway_Homo sapiens_hsa041520.06018574
151Renal cell carcinoma_Homo sapiens_hsa052110.04930275
152Small cell lung cancer_Homo sapiens_hsa052220.03726685

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