EDNRA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cardiac myofibril assembly (GO:0055003)5.61291519
2regulation of transforming growth factor beta2 production (GO:0032909)5.35433078
3cell proliferation involved in metanephros development (GO:0072203)5.06205455
4negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.94274834
5cell migration involved in heart development (GO:0060973)4.71050785
6planar cell polarity pathway involved in neural tube closure (GO:0090179)4.62530876
7endocardial cushion morphogenesis (GO:0003203)4.52374122
8regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)4.48974615
9regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.41973375
10myofibril assembly (GO:0030239)4.37414382
11mesenchyme morphogenesis (GO:0072132)4.33147884
12generation of neurons (GO:0048699)4.29601913
13metanephric mesenchyme development (GO:0072075)4.24720921
14bone trabecula formation (GO:0060346)4.23624111
15cell proliferation involved in kidney development (GO:0072111)4.08525659
16lateral sprouting from an epithelium (GO:0060601)4.02129707
17negative regulation of striated muscle cell apoptotic process (GO:0010664)3.97919046
18regulation of secondary heart field cardioblast proliferation (GO:0003266)3.94574296
19regulation of cardioblast proliferation (GO:0003264)3.94574296
20regulation of non-canonical Wnt signaling pathway (GO:2000050)3.91789441
21kidney mesenchyme development (GO:0072074)3.85747878
22G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.79910000
23axon extension involved in axon guidance (GO:0048846)3.75756095
24neuron projection extension involved in neuron projection guidance (GO:1902284)3.75756095
25protein heterotrimerization (GO:0070208)3.74852752
26negative regulation of cartilage development (GO:0061037)3.73630655
27hemidesmosome assembly (GO:0031581)3.61219240
28trabecula formation (GO:0060343)3.57078044
29cardiac muscle cell proliferation (GO:0060038)3.55272146
30sequestering of extracellular ligand from receptor (GO:0035581)3.52604674
31sarcomere organization (GO:0045214)3.52077613
32smooth muscle cell differentiation (GO:0051145)3.50524765
33vascular endothelial growth factor signaling pathway (GO:0038084)3.49997083
34epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.46994992
35collagen fibril organization (GO:0030199)3.45460243
36regulation of heart morphogenesis (GO:2000826)3.44713007
37heart trabecula formation (GO:0060347)3.40585128
38glomerular basement membrane development (GO:0032836)3.39382273
39heart valve morphogenesis (GO:0003179)3.39305642
40collagen catabolic process (GO:0030574)3.38322684
41midgut development (GO:0007494)3.38243464
42chondrocyte proliferation (GO:0035988)3.37792807
43cardiac muscle cell development (GO:0055013)3.36987345
44gonadal mesoderm development (GO:0007506)3.36856863
45negative regulation of axon extension involved in axon guidance (GO:0048843)3.35511747
46chondrocyte development (GO:0002063)3.33461453
47peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.32027083
48outflow tract septum morphogenesis (GO:0003148)3.31875155
49convergent extension (GO:0060026)3.31801311
50collagen metabolic process (GO:0032963)3.30757631
51endodermal cell differentiation (GO:0035987)3.29787098
52negative regulation of catenin import into nucleus (GO:0035414)3.29628671
53gland morphogenesis (GO:0022612)3.28605726
54mesenchymal-epithelial cell signaling (GO:0060638)3.26947703
55heart morphogenesis (GO:0003007)3.24342343
56paraxial mesoderm development (GO:0048339)3.24090579
57cardiac cell development (GO:0055006)3.22068986
58Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.20552004
59glomerulus development (GO:0032835)3.19909914
60mesenchyme development (GO:0060485)3.18182378
61extracellular fibril organization (GO:0043206)3.17946117
62positive regulation of catenin import into nucleus (GO:0035413)3.17757013
63outer ear morphogenesis (GO:0042473)3.15847168
64myoblast migration (GO:0051451)3.15295269
65regulation of establishment of planar polarity (GO:0090175)3.14211737
66positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.12324349
67positive regulation of epithelial to mesenchymal transition (GO:0010718)3.11488664
68regulation of axon extension involved in axon guidance (GO:0048841)3.11167132
69multicellular organismal catabolic process (GO:0044243)3.10168884
70atrial septum morphogenesis (GO:0060413)3.09066659
71hippo signaling (GO:0035329)3.08940894
72multicellular organismal macromolecule metabolic process (GO:0044259)3.08684237
73craniofacial suture morphogenesis (GO:0097094)3.08674879
74regulation of cell proliferation involved in heart morphogenesis (GO:2000136)3.07835856
75basement membrane organization (GO:0071711)3.07399817
76negative regulation of chondrocyte differentiation (GO:0032331)3.07153564
77positive regulation of mesenchymal cell proliferation (GO:0002053)3.07008537
78muscle cell migration (GO:0014812)3.06643767
79organ induction (GO:0001759)3.06405850
80glial cell migration (GO:0008347)3.03658369
81mesenchymal cell proliferation (GO:0010463)3.03639481
82keratan sulfate catabolic process (GO:0042340)3.02911461
83regulation of cardioblast differentiation (GO:0051890)3.02851890
84insulin-like growth factor receptor signaling pathway (GO:0048009)3.02047874
85regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.00049373
86regulation of mesenchymal cell proliferation (GO:0010464)2.99823640
87regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.99590635
88cardiac epithelial to mesenchymal transition (GO:0060317)2.98871623
89dermatan sulfate metabolic process (GO:0030205)2.98734515
90anatomical structure regression (GO:0060033)2.98152177
91extracellular matrix disassembly (GO:0022617)2.98066938
92atrioventricular valve morphogenesis (GO:0003181)2.97629551
93embryonic digestive tract development (GO:0048566)2.96874621
94aorta morphogenesis (GO:0035909)2.95085154
95striated muscle cell proliferation (GO:0014855)2.94797762
96coronary vasculature morphogenesis (GO:0060977)2.94271281
97negative regulation of embryonic development (GO:0045992)2.93255706
98negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.92926053
99lymph vessel development (GO:0001945)2.92400956
100negative regulation of potassium ion transmembrane transport (GO:1901380)2.92026689
101regulation of catenin import into nucleus (GO:0035412)2.91752008
102multicellular organismal metabolic process (GO:0044236)2.91691553
103* mesenchymal cell development (GO:0014031)2.91414089
104regulation of striated muscle cell apoptotic process (GO:0010662)2.90961954
105actomyosin structure organization (GO:0031032)2.89503208
106middle ear morphogenesis (GO:0042474)2.89472385
107actin-myosin filament sliding (GO:0033275)2.88840051
108muscle filament sliding (GO:0030049)2.88840051
109cardiac muscle tissue development (GO:0048738)2.88552463
110endocardial cushion development (GO:0003197)2.88467657
111smooth muscle tissue development (GO:0048745)2.88430056
112outflow tract morphogenesis (GO:0003151)2.87892981
113ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.87299280
114retina vasculature morphogenesis in camera-type eye (GO:0061299)2.86966298
115establishment of planar polarity (GO:0001736)2.86326213
116establishment of tissue polarity (GO:0007164)2.86326213
117cardiac muscle tissue morphogenesis (GO:0055008)2.85147619
118embryonic skeletal joint morphogenesis (GO:0060272)2.85035694
119embryonic cranial skeleton morphogenesis (GO:0048701)2.84919478
120* glomerular filtration (GO:0003094)2.83622865
121plasma membrane repair (GO:0001778)2.82994383
122regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.80620942
123artery morphogenesis (GO:0048844)2.80517109
124vasculature development (GO:0001944)2.80400570
125embryonic camera-type eye morphogenesis (GO:0048596)2.80389239
126peripheral nervous system neuron development (GO:0048935)2.79977298
127Notch signaling involved in heart development (GO:0061314)2.79966284
128cochlea morphogenesis (GO:0090103)2.79792252
129regulation of cardiac muscle cell apoptotic process (GO:0010665)2.79516388
130pathway-restricted SMAD protein phosphorylation (GO:0060389)2.78338158
131cardiac muscle contraction (GO:0060048)2.77736666
132dermatan sulfate biosynthetic process (GO:0030208)2.77396573
133muscle tissue morphogenesis (GO:0060415)2.77395343
134camera-type eye morphogenesis (GO:0048593)2.77140905
135palate development (GO:0060021)2.76152840
136non-canonical Wnt signaling pathway (GO:0035567)2.76065562
137positive regulation of fat cell differentiation (GO:0045600)2.75921101
138regulation of axon guidance (GO:1902667)2.74269598
139negative regulation of axon guidance (GO:1902668)2.74061991
140adult heart development (GO:0007512)2.74016770
141blood vessel maturation (GO:0001955)2.73626807
142body morphogenesis (GO:0010171)2.71652087
143extracellular matrix assembly (GO:0085029)2.71252984
144cellular response to BMP stimulus (GO:0071773)2.70081005
145response to BMP (GO:0071772)2.70081005
146regulation of hair follicle development (GO:0051797)2.66631624
147regulation of macrophage cytokine production (GO:0010935)2.65195267
148fibril organization (GO:0097435)2.64775045

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.70833834
2RBPJ_22232070_ChIP-Seq_NCS_Mouse4.01718756
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.61630778
4EP300_21415370_ChIP-Seq_HL-1_Mouse3.33244990
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.19775688
6* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.89089634
7PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.74909097
8EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.73905708
9WT1_19549856_ChIP-ChIP_CCG9911_Human2.71912932
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.56502740
11PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.39517459
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.31172865
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.29109646
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.19673117
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.19673117
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.18284018
17CLOCK_20551151_ChIP-Seq_293T_Human2.17134994
18* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.14077314
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.12783496
20TP63_19390658_ChIP-ChIP_HaCaT_Human2.11719787
21* ISL1_27105846_Chip-Seq_CPCs_Mouse2.09071323
22EZH2_27304074_Chip-Seq_ESCs_Mouse2.09056874
23RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.06774654
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.06367809
25* CDX2_19796622_ChIP-Seq_MESCs_Mouse2.02842614
26WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.93078854
27TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.92029240
28RARG_19884340_ChIP-ChIP_MEFs_Mouse1.85061088
29ESR1_20079471_ChIP-ChIP_T-47D_Human1.82074501
30TBX20_22080862_ChIP-Seq_HEART_Mouse1.81210209
31TBX20_22328084_ChIP-Seq_HEART_Mouse1.81210209
32SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.73900834
33TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.71562214
34CJUN_26792858_Chip-Seq_BT549_Human1.70288101
35JARID2_20075857_ChIP-Seq_MESCs_Mouse1.64540717
36JARID2_20064375_ChIP-Seq_MESCs_Mouse1.62338391
37SALL1_21062744_ChIP-ChIP_HESCs_Human1.60202918
38SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.59060054
39TP53_20018659_ChIP-ChIP_R1E_Mouse1.58534910
40RNF2_27304074_Chip-Seq_ESCs_Mouse1.58468247
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.57946696
42MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.56715473
43CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.53500183
44NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.53276554
45NRF2_20460467_ChIP-Seq_MEFs_Mouse1.53276554
46TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.52688298
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.50841946
48KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.48344722
49KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.48344722
50KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.48344722
51DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.46653737
52BRD4_25478319_ChIP-Seq_HGPS_Human1.46064572
53ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.45477175
54TP53_18474530_ChIP-ChIP_U2OS_Human1.44569214
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.42067227
56SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.41526870
57PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.40371769
58PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39656487
59ZNF217_24962896_ChIP-Seq_MCF-7_Human1.39460296
60EZH2_22144423_ChIP-Seq_EOC_Human1.38805323
61BCAT_22108803_ChIP-Seq_LS180_Human1.38405346
62* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.35737096
63CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.33577546
64* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.33532132
65HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.32901318
66FUS_26573619_Chip-Seq_HEK293_Human1.32878230
67GBX2_23144817_ChIP-Seq_PC3_Human1.30031892
68BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.29819448
69NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.26180626
70ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.24625370
71RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.23918791
72* SMAD3_21741376_ChIP-Seq_EPCs_Human1.22169736
73POU5F1_16153702_ChIP-ChIP_HESCs_Human1.21458558
74SALL4_18804426_ChIP-ChIP_XEN_Mouse1.21290670
75TP63_17297297_ChIP-ChIP_HaCaT_Human1.20870712
76OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20742493
77TCF4_18268006_ChIP-ChIP_LS174T_Human1.20319200
78ZFP57_27257070_Chip-Seq_ESCs_Mouse1.19376487
79* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18464358
80TP53_16413492_ChIP-PET_HCT116_Human1.16053490
81RNF2_27304074_Chip-Seq_NSC_Mouse1.14661883
82FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.14028912
83* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.13922632
84HIF1A_21447827_ChIP-Seq_MCF-7_Human1.13812135
85RING1B_27294783_Chip-Seq_ESCs_Mouse1.13163158
86* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11973675
87ARNT_22903824_ChIP-Seq_MCF-7_Human1.11512862
88NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10952907
89AHR_22903824_ChIP-Seq_MCF-7_Human1.09670829
90ZNF274_21170338_ChIP-Seq_K562_Hela1.08918517
91EZH2_27294783_Chip-Seq_ESCs_Mouse1.07823770
92RING1B_27294783_Chip-Seq_NPCs_Mouse1.07548902
93* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07188113
94AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06603881
95STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.06405707
96TBX3_20139965_ChIP-Seq_ESCs_Mouse1.06133682
97* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05437820
98TBX3_20139965_ChIP-Seq_MESCs_Mouse1.05045047
99SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.02756807
100PPAR_26484153_Chip-Seq_NCI-H1993_Human1.02323754
101AR_21572438_ChIP-Seq_LNCaP_Human1.02161804
102SMAD3_21741376_ChIP-Seq_HESCs_Human1.01995380
103TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01747031
104SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00946834
105SMAD_19615063_ChIP-ChIP_OVARY_Human1.00202700
106SMAD4_21799915_ChIP-Seq_A2780_Human0.98978351
107* SA1_22415368_ChIP-Seq_MEFs_Mouse0.98951164
108ZFP281_18757296_ChIP-ChIP_E14_Mouse0.97635718
109SUZ12_27294783_Chip-Seq_ESCs_Mouse0.97433793
110TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.96865594
111NFIB_24661679_ChIP-Seq_LUNG_Mouse0.96316097
112GATA4_21415370_ChIP-Seq_HL-1_Mouse0.95969964
113SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.95662400
114NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.95660002
115SMC1_22415368_ChIP-Seq_MEFs_Mouse0.95309942
116NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.95088664
117ESR1_21235772_ChIP-Seq_MCF-7_Human0.95052391
118CTNNB1_20460455_ChIP-Seq_HCT116_Human0.94506303
119* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.93894558
120ESR2_21235772_ChIP-Seq_MCF-7_Human0.93818362
121FOXM1_26456572_ChIP-Seq_MCF-7_Human0.93001255
122ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.92229578
123SMAD4_21741376_ChIP-Seq_HESCs_Human0.89755816
124NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.89537868
125CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88917747
126SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.88810803
127TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88257232

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.99565398
2MP0005503_abnormal_tendon_morphology3.96525430
3MP0004272_abnormal_basement_membrane3.13606422
4MP0003122_maternal_imprinting3.07883289
5MP0004084_abnormal_cardiac_muscle3.06774628
6MP0003283_abnormal_digestive_organ2.81945710
7MP0002837_dystrophic_cardiac_calcinosis2.79084035
8MP0003279_aneurysm2.77030750
9MP0009384_cardiac_valve_regurgitation2.55146726
10MP0003385_abnormal_body_wall2.51953447
11MP0000751_myopathy2.51765837
12MP0009053_abnormal_anal_canal2.37801182
13MP0010030_abnormal_orbit_morphology2.37032582
14MP0005275_abnormal_skin_tensile2.33194918
15MP0010368_abnormal_lymphatic_system2.25499307
16MP0009250_abnormal_appendicular_skeleto2.25020937
17MP0004215_abnormal_myocardial_fiber2.22035754
18MP0000462_abnormal_digestive_system2.14020692
19MP0003942_abnormal_urinary_system2.10842824
20MP0003705_abnormal_hypodermis_morpholog2.09088636
21MP0006138_congestive_heart_failure2.08546911
22MP0000534_abnormal_ureter_morphology1.97545032
23MP0004036_abnormal_muscle_relaxation1.95923816
24MP0002249_abnormal_larynx_morphology1.94393650
25MP0006054_spinal_hemorrhage1.92509189
26MP0002938_white_spotting1.90167517
27MP0005330_cardiomyopathy1.84752879
28MP0002972_abnormal_cardiac_muscle1.82896034
29MP0003828_pulmonary_edema1.81079275
30MP0008775_abnormal_heart_ventricle1.81008984
31MP0010630_abnormal_cardiac_muscle1.76081862
32MP0001958_emphysema1.73183489
33MP0002108_abnormal_muscle_morphology1.72880149
34MP0000767_abnormal_smooth_muscle1.71168541
35MP0005508_abnormal_skeleton_morphology1.67600938
36MP0001879_abnormal_lymphatic_vessel1.65449382
37MP0005385_cardiovascular_system_phenoty1.65086973
38MP0001544_abnormal_cardiovascular_syste1.65086973
39MP0002282_abnormal_trachea_morphology1.64993566
40MP0005623_abnormal_meninges_morphology1.64393611
41MP0003567_abnormal_fetal_cardiomyocyte1.60186092
42MP0004087_abnormal_muscle_fiber1.59774105
43MP0002127_abnormal_cardiovascular_syste1.56879224
44MP0009780_abnormal_chondrocyte_physiolo1.56282459
45MP0004484_altered_response_of1.55881352
46* MP0000049_abnormal_middle_ear1.55443588
47MP0005620_abnormal_muscle_contractility1.52734354
48MP0003137_abnormal_impulse_conducting1.52601511
49MP0001177_atelectasis1.52562032
50* MP0003935_abnormal_craniofacial_develop1.52246637
51MP0003121_genomic_imprinting1.45050392
52MP0002932_abnormal_joint_morphology1.44085154
53MP0003755_abnormal_palate_morphology1.43888916
54MP0003937_abnormal_limbs/digits/tail_de1.41624639
55MP0000579_abnormal_nail_morphology1.41576487
56MP0003115_abnormal_respiratory_system1.41239003
57MP0000749_muscle_degeneration1.41071311
58MP0003941_abnormal_skin_development1.40950551
59MP0000537_abnormal_urethra_morphology1.40763192
60MP0005187_abnormal_penis_morphology1.36183704
61MP0005257_abnormal_intraocular_pressure1.35367494
62MP0000733_abnormal_muscle_development1.33344957
63* MP0000762_abnormal_tongue_morphology1.32564977
64MP0005171_absent_coat_pigmentation1.28749929
65MP0000750_abnormal_muscle_regeneration1.27704663
66MP0003123_paternal_imprinting1.27113710
67MP0004085_abnormal_heartbeat1.26861671
68MP0003119_abnormal_digestive_system1.22642252
69MP0002128_abnormal_blood_circulation1.18582956
70MP0003566_abnormal_cell_adhesion1.17646831
71* MP0000266_abnormal_heart_morphology1.16518175
72MP0005023_abnormal_wound_healing1.16126085
73MP0005369_muscle_phenotype1.15452991
74MP0003091_abnormal_cell_migration1.13140939
75MP0005388_respiratory_system_phenotype1.12148837
76MP0001270_distended_abdomen1.10994108
77MP0002109_abnormal_limb_morphology1.09827758
78MP0004233_abnormal_muscle_weight1.09523035
79MP0001346_abnormal_lacrimal_gland1.09148597
80* MP0002925_abnormal_cardiovascular_devel1.08524196
81* MP0000428_abnormal_craniofacial_morphol1.08280341
82MP0005367_renal/urinary_system_phenotyp1.06697646
83MP0000516_abnormal_urinary_system1.06697646
84MP0002233_abnormal_nose_morphology1.05947842
85* MP0000163_abnormal_cartilage_morphology1.04444768
86MP0002896_abnormal_bone_mineralization1.03895524
87MP0002115_abnormal_skeleton_extremities1.02796320
88MP0002106_abnormal_muscle_physiology1.00927400
89MP0001299_abnormal_eye_distance/0.99653252
90MP0005197_abnormal_uvea_morphology0.99552820
91MP0002295_abnormal_pulmonary_circulatio0.97364286
92* MP0002116_abnormal_craniofacial_bone0.97035285
93MP0002114_abnormal_axial_skeleton0.95150168
94MP0000759_abnormal_skeletal_muscle0.95115134
95MP0001293_anophthalmia0.93634827
96MP0005390_skeleton_phenotype0.93337452
97MP0005248_abnormal_Harderian_gland0.91949438
98* MP0000432_abnormal_head_morphology0.91807301
99* MP0001614_abnormal_blood_vessel0.90937525
100MP0000566_synostosis0.89021585
101MP0004145_abnormal_muscle_electrophysio0.87460912
102MP0000343_altered_response_to0.87221945
103MP0001175_abnormal_lung_morphology0.86664393
104MP0002113_abnormal_skeleton_development0.83020863
105MP0005595_abnormal_vascular_smooth0.83012500
106MP0002009_preneoplasia0.78504000
107MP0008789_abnormal_olfactory_epithelium0.77096216
108MP0005409_darkened_coat_color0.76196759
109MP0004130_abnormal_muscle_cell0.75670141
110MP0004134_abnormal_chest_morphology0.73963473
111MP0002111_abnormal_tail_morphology0.73928546
112MP0002697_abnormal_eye_size0.73864259
113MP0009703_decreased_birth_body0.73792388
114MP0002396_abnormal_hematopoietic_system0.73349163
115MP0000467_abnormal_esophagus_morphology0.72454165
116MP0002060_abnormal_skin_morphology0.70665725
117MP0000003_abnormal_adipose_tissue0.69686574
118MP0003646_muscle_fatigue0.68116531
119MP0001340_abnormal_eyelid_morphology0.67856271
120MP0005193_abnormal_anterior_eye0.67226044
121MP0001286_abnormal_eye_development0.67076740
122MP0002133_abnormal_respiratory_system0.67052640
123MP0002751_abnormal_autonomic_nervous0.65526786
124MP0005164_abnormal_response_to0.65286218
125MP0004858_abnormal_nervous_system0.64188150
126MP0001542_abnormal_bone_strength0.63814433

Predicted human phenotypes

RankGene SetZ-score
1Arterial tortuosity (HP:0005116)5.02250928
2Short 4th metacarpal (HP:0010044)4.90682043
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.90682043
4Vascular tortuosity (HP:0004948)4.81383138
5Broad metatarsal (HP:0001783)4.72592744
6Protrusio acetabuli (HP:0003179)4.37592718
7Abnormality of the 4th metacarpal (HP:0010012)4.17053346
8Shallow orbits (HP:0000586)3.84525852
9Ankle contracture (HP:0006466)3.71191665
10Premature rupture of membranes (HP:0001788)3.68747588
11Midline defect of the nose (HP:0004122)3.53941252
12Sudden death (HP:0001699)3.50803581
13Aortic dissection (HP:0002647)3.47813963
14Aortic aneurysm (HP:0004942)3.28666880
15Follicular hyperkeratosis (HP:0007502)3.28628492
16Calcaneovalgus deformity (HP:0001848)3.24904478
17Spondylolisthesis (HP:0003302)3.18783333
18Pulmonary artery stenosis (HP:0004415)3.16439942
19Ventricular tachycardia (HP:0004756)3.15285911
20Peritonitis (HP:0002586)3.15137603
21Type 1 muscle fiber predominance (HP:0003803)3.14181717
22Atrial fibrillation (HP:0005110)3.08361760
23Genu recurvatum (HP:0002816)2.98240390
24Lymphangioma (HP:0100764)2.94358253
25Renal duplication (HP:0000075)2.93053443
26Deformed tarsal bones (HP:0008119)2.88910484
27Lipoatrophy (HP:0100578)2.86478942
28Infantile muscular hypotonia (HP:0008947)2.86394193
29Primary atrial arrhythmia (HP:0001692)2.84368262
30Broad toe (HP:0001837)2.83977855
31Wide anterior fontanel (HP:0000260)2.83565868
32Increased connective tissue (HP:0009025)2.82598661
33Abnormality of the calf musculature (HP:0001430)2.77088290
34Supraventricular arrhythmia (HP:0005115)2.75985854
35Cerebral aneurysm (HP:0004944)2.75038805
36Bladder diverticulum (HP:0000015)2.70953679
37Supraventricular tachycardia (HP:0004755)2.69326728
38Soft skin (HP:0000977)2.67825612
39Short hallux (HP:0010109)2.64461831
40Mesomelia (HP:0003027)2.62643425
41Abnormality of the parietal bone (HP:0002696)2.61049804
42Hepatoblastoma (HP:0002884)2.56935534
43Subaortic stenosis (HP:0001682)2.50125928
44Abnormality of the left ventricular outflow tract (HP:0011103)2.50125928
45Increased variability in muscle fiber diameter (HP:0003557)2.47080706
46Bowel diverticulosis (HP:0005222)2.45516469
47Alopecia of scalp (HP:0002293)2.43445213
48Right ventricular cardiomyopathy (HP:0011663)2.43066381
49Hypoplastic ischia (HP:0003175)2.40327293
50Aplasia/Hypoplasia of the hallux (HP:0008362)2.38226549
51Asymmetry of the thorax (HP:0001555)2.37582637
52Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.37434501
53Preaxial foot polydactyly (HP:0001841)2.36834486
54Trigonocephaly (HP:0000243)2.35505987
55Overgrowth (HP:0001548)2.35481657
56Spinal rigidity (HP:0003306)2.31541092
57Abnormality of the calcaneus (HP:0008364)2.30595974
58Calf muscle hypertrophy (HP:0008981)2.30301178
59Microglossia (HP:0000171)2.26930090
60Hyperextensible skin (HP:0000974)2.26523128
61Short middle phalanx of the 5th finger (HP:0004220)2.24610570
62Coronal craniosynostosis (HP:0004440)2.24196139
63Ectopia lentis (HP:0001083)2.23579822
64Cervical subluxation (HP:0003308)2.23508653
65Broad hallux (HP:0010055)2.23111535
66Mildly elevated creatine phosphokinase (HP:0008180)2.22611638
67Abnormality of the right ventricle (HP:0001707)2.19962107
68Lip pit (HP:0100267)2.15589808
69Osteoarthritis (HP:0002758)2.14706538
70Abnormality of the ischium (HP:0003174)2.13881736
71Hallux valgus (HP:0001822)2.11732508
72Hypoplasia of the iris (HP:0007676)2.11429128
73Mitral valve prolapse (HP:0001634)2.11313303
74Slender build (HP:0001533)2.11073517
75Mild short stature (HP:0003502)2.09603229
76Bell-shaped thorax (HP:0001591)2.08473010
77Morphological abnormality of the middle ear (HP:0008609)2.07948922
78Venous insufficiency (HP:0005293)2.07903276
79Abnormality of skeletal muscle fiber size (HP:0012084)2.07656388
80Epiphyseal dysplasia (HP:0002656)2.07032681
81Aneurysm (HP:0002617)2.06247668
82Blue sclerae (HP:0000592)2.05109404
83Atrophic scars (HP:0001075)2.03454149
84Exercise-induced muscle cramps (HP:0003710)2.01263680
85Cutaneous finger syndactyly (HP:0010554)2.00897244
86Abnormality of dentin (HP:0010299)2.00105681
87Hyporeflexia of lower limbs (HP:0002600)1.99677555
88Rectal prolapse (HP:0002035)1.97639824
89Dilated cardiomyopathy (HP:0001644)1.97321393
90Narrow palate (HP:0000189)1.96465579
91Joint laxity (HP:0001388)1.95344468
92Prolonged QT interval (HP:0001657)1.94314296
93Osteolytic defects of the phalanges of the hand (HP:0009771)1.94268150
94Osteolytic defects of the hand bones (HP:0009699)1.94268150
95Vertebral arch anomaly (HP:0008438)1.94084618
96Prominent supraorbital ridges (HP:0000336)1.91175462
97Muscle hypertrophy of the lower extremities (HP:0008968)1.88896299
98Syncope (HP:0001279)1.88796689
99Fragile skin (HP:0001030)1.88794774
100Muscle fiber splitting (HP:0003555)1.88007485
101Inguinal hernia (HP:0000023)1.86545902
102Wide cranial sutures (HP:0010537)1.85919324
103Broad long bones (HP:0005622)1.85837531
104Venous abnormality (HP:0002624)1.85027382
105Abnormality of the nasolacrimal system (HP:0000614)1.84456453
106Bicuspid aortic valve (HP:0001647)1.83214495
107Abnormality of the pubic bones (HP:0003172)1.83206465
108Wormian bones (HP:0002645)1.82947941
109Dilatation of the ascending aorta (HP:0005111)1.82800795
110Syringomyelia (HP:0003396)1.82275924
111Spinal cord lesions (HP:0100561)1.82275924
112Vitreoretinal degeneration (HP:0000655)1.81137432
113Buphthalmos (HP:0000557)1.80093879
114Gingival overgrowth (HP:0000212)1.79151212
115Limited hip movement (HP:0008800)1.78919632
116Abnormal delivery (HP:0001787)1.78613364
117Deviation of the hallux (HP:0010051)1.77200641
118Hypoplastic left heart (HP:0004383)1.77178942
119Scapular winging (HP:0003691)1.77125847
120Camptodactyly of toe (HP:0001836)1.76829072
121Hip contracture (HP:0003273)1.76732259
122Abnormality of the phalanges of the hallux (HP:0010057)1.76659913
123Knee flexion contracture (HP:0006380)1.75570860
124Turricephaly (HP:0000262)1.75243402
125Long eyelashes (HP:0000527)1.75116886
126Exostoses (HP:0100777)1.74193924
127Neonatal short-limb short stature (HP:0008921)1.73502929
128Partial duplication of the phalanx of hand (HP:0009999)1.73253754
129Protruding ear (HP:0000411)1.72993475
130Cutaneous syndactyly (HP:0012725)1.72281999
131Abnormality of the phalanges of the 2nd finger (HP:0009541)1.72013347
132Increased number of teeth (HP:0011069)1.71631873
133Bone cyst (HP:0012062)1.71576663
134Exercise-induced myalgia (HP:0003738)1.70936485
135Hypoplastic heart (HP:0001961)1.70891719
136Cupped ribs (HP:0000887)1.68515553
137Platyspondyly (HP:0000926)1.65803519
138Keratoconus (HP:0000563)1.62930856
139Increased corneal curvature (HP:0100692)1.62930856
140Arachnodactyly (HP:0001166)1.62473507
141Shawl scrotum (HP:0000049)1.62437647
142Aortic valve stenosis (HP:0001650)1.62292225
143Fragile nails (HP:0001808)1.61745401
144Hypoplasia of the maxilla (HP:0000327)1.60611383

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MYLK4.38404118
2EPHA33.96104932
3TTN3.70491427
4PDGFRA3.59354372
5LATS13.38564782
6DMPK3.28032968
7EPHB22.55395087
8TRIB32.47534704
9LMTK22.33102994
10DDR22.24958739
11PNCK2.21818151
12SIK12.15060917
13PIK3CA2.13741779
14TIE12.12184392
15NTRK12.12033964
16OBSCN2.02831459
17MAPK152.00749715
18STK38L1.83034572
19PKN21.82003456
20TGFBR21.75076961
21LATS21.69673600
22FGFR21.65655489
23ZAK1.58132344
24CDC42BPA1.53236158
25NEK91.45880505
26STK241.45730786
27CAMK1D1.45188297
28STK391.43940113
29NUAK11.41479470
30NLK1.38578490
31PHKG21.38446428
32PHKG11.38446428
33RIPK11.38171336
34PAK31.38092457
35FGFR11.31581081
36PDGFRB1.29830431
37CAMK1G1.27112781
38STK31.25241488
39PAK21.24341681
40TGFBR11.23441489
41ROCK11.22951744
42FRK1.19047533
43PTK2B1.15599303
44ERN11.13818065
45WNK11.10145682
46ILK1.08893104
47MKNK11.03930952
48PTK61.00473562
49MKNK20.96643109
50AKT30.96254330
51PRKD30.95479979
52INSRR0.95399667
53CDK30.89703185
54PRKD10.89028690
55RAF10.87922482
56MET0.87856101
57ERBB40.86446054
58PRKAA20.83820422
59KIT0.83808527
60FER0.81781298
61MOS0.80797816
62PDK30.80562090
63PDK40.80562090
64MTOR0.79256407
65GRK70.79004625
66ADRBK10.78501406
67CLK10.77151198
68KDR0.72261515
69MAP3K100.70201866
70MAP3K20.69001256
71ERBB30.68817561
72PTK20.68694468
73NTRK20.68032815
74CDK120.67698058
75FGFR30.65658983
76ICK0.61292472
77RPS6KA40.60283291
78TRPM70.59834721
79PRKCE0.58862785
80CAMK40.58485826
81FGFR40.58356227
82BMX0.57911442
83MELK0.55121887
84ERBB20.54330887
85CASK0.54184323
86PRKCH0.52794341
87WNK40.50794497
88DYRK30.48624791
89NTRK30.46506063
90MAP3K70.45997817
91KSR20.45665807
92ROCK20.44469708
93INSR0.44461250
94STK40.44185276
95FLT30.43727201
96SGK20.42633355
97RPS6KA60.41370539
98LRRK20.40772923
99PIK3CG0.40234565
100DAPK30.40196910
101RPS6KA20.39218401
102MAPK120.38733616
103PDK20.37582157
104NEK20.37383315
105IGF1R0.36696641
106MAP2K10.34775773
107MAP3K60.34733206
108BCKDK0.34704484
109CAMK10.34426197
110EPHB10.34316676
111MAPK70.34287838
112SGK30.34242296
113DYRK1A0.34203393
114PLK20.32342731
115MAPK100.32312176
116EEF2K0.32264717
117RPS6KL10.30983100
118RPS6KC10.30983100
119PRKACB0.30634478
120OXSR10.29260456
121PAK40.28256279
122CAMK2D0.28030156
123CSNK1A1L0.27225610
124MAPK10.27065473
125NEK10.27039793
126PRKG10.26959311
127SRC0.26489988
128CDK80.26371257
129STK380.26217856
130PRKAA10.26009374
131GSK3A0.26005285
132MAPK40.25843345
133MAPKAPK50.25448463
134TYRO30.25043921
135AKT10.23010797
136RET0.22883213

Predicted pathways (KEGG)

RankGene SetZ-score
1Dilated cardiomyopathy_Homo sapiens_hsa054143.61994028
2Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.43495737
3ECM-receptor interaction_Homo sapiens_hsa045123.12514255
4Basal cell carcinoma_Homo sapiens_hsa052172.83387270
5Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.81857968
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.80388384
7Focal adhesion_Homo sapiens_hsa045102.51644666
8Hedgehog signaling pathway_Homo sapiens_hsa043402.49683155
9Adherens junction_Homo sapiens_hsa045202.26909066
10Cardiac muscle contraction_Homo sapiens_hsa042602.03316242
11TGF-beta signaling pathway_Homo sapiens_hsa043501.98506572
12Fatty acid degradation_Homo sapiens_hsa000711.97832623
13Protein digestion and absorption_Homo sapiens_hsa049741.89418508
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.87451431
15Propanoate metabolism_Homo sapiens_hsa006401.83215056
16Hippo signaling pathway_Homo sapiens_hsa043901.82844568
17Proteoglycans in cancer_Homo sapiens_hsa052051.76033933
18Viral myocarditis_Homo sapiens_hsa054161.74004649
19Lysine degradation_Homo sapiens_hsa003101.60755492
20Fatty acid metabolism_Homo sapiens_hsa012121.56707128
21Wnt signaling pathway_Homo sapiens_hsa043101.43059584
22Small cell lung cancer_Homo sapiens_hsa052221.40862174
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.39101801
24Amoebiasis_Homo sapiens_hsa051461.38041488
25* cGMP-PKG signaling pathway_Homo sapiens_hsa040221.37266077
26Axon guidance_Homo sapiens_hsa043601.36753965
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.32903206
28MicroRNAs in cancer_Homo sapiens_hsa052061.30933936
29Notch signaling pathway_Homo sapiens_hsa043301.25486838
30Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.25375299
31PI3K-Akt signaling pathway_Homo sapiens_hsa041511.23091062
32Renin-angiotensin system_Homo sapiens_hsa046141.19298601
33PPAR signaling pathway_Homo sapiens_hsa033201.18907355
34Insulin resistance_Homo sapiens_hsa049311.17745148
35* Pathways in cancer_Homo sapiens_hsa052001.16844473
36AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.16520478
37* Vascular smooth muscle contraction_Homo sapiens_hsa042701.16121136
38Ovarian steroidogenesis_Homo sapiens_hsa049131.14457588
39Prostate cancer_Homo sapiens_hsa052151.13339056
40Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.12330806
41Melanogenesis_Homo sapiens_hsa049161.10172734
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.07352414
43Melanoma_Homo sapiens_hsa052181.04433238
44Tight junction_Homo sapiens_hsa045301.00166840
45Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.99100546
46Central carbon metabolism in cancer_Homo sapiens_hsa052300.92635689
47Thyroid hormone signaling pathway_Homo sapiens_hsa049190.91700635
48Regulation of actin cytoskeleton_Homo sapiens_hsa048100.89566870
49Salivary secretion_Homo sapiens_hsa049700.87594566
50Rap1 signaling pathway_Homo sapiens_hsa040150.86364825
51Phospholipase D signaling pathway_Homo sapiens_hsa040720.86059608
52Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.85039565
53Prion diseases_Homo sapiens_hsa050200.84659440
54Carbon metabolism_Homo sapiens_hsa012000.84049009
55Glucagon signaling pathway_Homo sapiens_hsa049220.80993118
56Platelet activation_Homo sapiens_hsa046110.80737466
57Cocaine addiction_Homo sapiens_hsa050300.78874573
58Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.77483590
59* cAMP signaling pathway_Homo sapiens_hsa040240.76115129
60Gap junction_Homo sapiens_hsa045400.75647516
61Tryptophan metabolism_Homo sapiens_hsa003800.75171573
62Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.74665963
63Leukocyte transendothelial migration_Homo sapiens_hsa046700.74093122
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73549803
65HTLV-I infection_Homo sapiens_hsa051660.73435140
66* Renin secretion_Homo sapiens_hsa049240.73072561
67Aldosterone synthesis and secretion_Homo sapiens_hsa049250.72580023
68AMPK signaling pathway_Homo sapiens_hsa041520.70558548
69Long-term depression_Homo sapiens_hsa047300.66910429
70Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66735963
71Dorso-ventral axis formation_Homo sapiens_hsa043200.63486291
72Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62339447
73GnRH signaling pathway_Homo sapiens_hsa049120.62262971
74Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.62224303
75Chronic myeloid leukemia_Homo sapiens_hsa052200.61467071
76Starch and sucrose metabolism_Homo sapiens_hsa005000.61284356
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.61068803
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60641651
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.58550256
80Insulin signaling pathway_Homo sapiens_hsa049100.58449041
81Type II diabetes mellitus_Homo sapiens_hsa049300.57872382
82HIF-1 signaling pathway_Homo sapiens_hsa040660.57066015
83Choline metabolism in cancer_Homo sapiens_hsa052310.56928042
84Endometrial cancer_Homo sapiens_hsa052130.55918559
85Complement and coagulation cascades_Homo sapiens_hsa046100.55658212
86Renal cell carcinoma_Homo sapiens_hsa052110.55168562
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54394572
88Glioma_Homo sapiens_hsa052140.54271705
89Pyruvate metabolism_Homo sapiens_hsa006200.53924908
90Pancreatic secretion_Homo sapiens_hsa049720.53816628
91ErbB signaling pathway_Homo sapiens_hsa040120.53324742
92Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52454632
93Oxytocin signaling pathway_Homo sapiens_hsa049210.52238163
94Estrogen signaling pathway_Homo sapiens_hsa049150.51562334
95Butanoate metabolism_Homo sapiens_hsa006500.50713775
96MAPK signaling pathway_Homo sapiens_hsa040100.50272988
97Thyroid hormone synthesis_Homo sapiens_hsa049180.48843318
98Toxoplasmosis_Homo sapiens_hsa051450.48257326
99Colorectal cancer_Homo sapiens_hsa052100.47670037
100Cholinergic synapse_Homo sapiens_hsa047250.46097345
101Amphetamine addiction_Homo sapiens_hsa050310.46066281
102Pancreatic cancer_Homo sapiens_hsa052120.45361950
103Insulin secretion_Homo sapiens_hsa049110.44832306
104Bladder cancer_Homo sapiens_hsa052190.43843197
105Mineral absorption_Homo sapiens_hsa049780.43441842
106Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.42979354
107* Calcium signaling pathway_Homo sapiens_hsa040200.42856464
108Sulfur metabolism_Homo sapiens_hsa009200.42356624
109Circadian rhythm_Homo sapiens_hsa047100.40038276
110Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.39256806
111Gastric acid secretion_Homo sapiens_hsa049710.38324464
112Phenylalanine metabolism_Homo sapiens_hsa003600.38088373
113Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37550779
114Malaria_Homo sapiens_hsa051440.36298657
115Fatty acid elongation_Homo sapiens_hsa000620.35928940
116Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.35630138
117Glutamatergic synapse_Homo sapiens_hsa047240.35513975
118Circadian entrainment_Homo sapiens_hsa047130.34790498
119Ras signaling pathway_Homo sapiens_hsa040140.34723098
120Serotonergic synapse_Homo sapiens_hsa047260.32739384
121FoxO signaling pathway_Homo sapiens_hsa040680.32593531
122Thyroid cancer_Homo sapiens_hsa052160.31886342
123Bile secretion_Homo sapiens_hsa049760.31815606
124Morphine addiction_Homo sapiens_hsa050320.31474470
125Glycosaminoglycan degradation_Homo sapiens_hsa005310.31259507
126Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.31009716
127Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.30351238
128Tyrosine metabolism_Homo sapiens_hsa003500.30156822
129Endocytosis_Homo sapiens_hsa041440.30031630
130Steroid hormone biosynthesis_Homo sapiens_hsa001400.29838410

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