EDNRB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternative splicing and the use of alternative promoters results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1alanine transport (GO:0032328)9.66138223
2L-serine transport (GO:0015825)8.31284480
3serine transport (GO:0032329)7.22861990
4melanin biosynthetic process (GO:0042438)6.07481965
5presynaptic membrane assembly (GO:0097105)5.90321170
6melanin metabolic process (GO:0006582)5.56328927
7secondary metabolite biosynthetic process (GO:0044550)5.55785247
8proline transport (GO:0015824)5.50735246
9atrial cardiac muscle cell action potential (GO:0086014)5.47732862
10amino acid import (GO:0043090)5.37915614
11negative regulation of sodium ion transport (GO:0010766)5.29981865
12postsynaptic membrane organization (GO:0001941)5.27220554
13presynaptic membrane organization (GO:0097090)5.21293116
14cellular response to cholesterol (GO:0071397)4.96648164
15astrocyte differentiation (GO:0048708)4.92441798
16low-density lipoprotein particle remodeling (GO:0034374)4.88153143
17C4-dicarboxylate transport (GO:0015740)4.86393220
18gonadal mesoderm development (GO:0007506)4.81249308
19negative regulation of oligodendrocyte differentiation (GO:0048715)4.78270145
20gamma-aminobutyric acid transport (GO:0015812)4.70045651
21regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.62150713
22G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.61397138
23neuronal stem cell maintenance (GO:0097150)4.61229223
24L-amino acid import (GO:0043092)4.60204510
25cell communication by electrical coupling (GO:0010644)4.38586988
26adenine nucleotide transport (GO:0051503)4.17176212
27retinal rod cell development (GO:0046548)4.11061514
28neuron cell-cell adhesion (GO:0007158)4.10393714
29positive regulation of vascular permeability (GO:0043117)4.07956518
30regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.04611742
31cellular potassium ion homeostasis (GO:0030007)4.00657211
32cellular response to sterol (GO:0036315)3.98859124
33gap junction assembly (GO:0016264)3.90248289
34positive regulation of extracellular matrix organization (GO:1903055)3.86405000
35endothelium development (GO:0003158)3.79991660
36purine ribonucleotide transport (GO:0015868)3.79799392
37negative regulation of neurotransmitter transport (GO:0051589)3.72946309
38heart valve formation (GO:0003188)3.71264498
39sodium ion export (GO:0071436)3.71219358
40negative regulation of protein localization to cell surface (GO:2000009)3.70995532
41response to auditory stimulus (GO:0010996)3.67552497
42protein localization to endosome (GO:0036010)3.63263229
43purine nucleotide transport (GO:0015865)3.60820771
44detection of temperature stimulus (GO:0016048)3.52965690
45auditory behavior (GO:0031223)3.46741686
46neurotransmitter uptake (GO:0001504)3.44429369
47glial cell differentiation (GO:0010001)3.42797756
48regulation of neurotransmitter uptake (GO:0051580)3.41256146
49chondroitin sulfate catabolic process (GO:0030207)3.39473696
50radial glial cell differentiation (GO:0060019)3.34030795
51positive regulation of astrocyte differentiation (GO:0048711)3.30793557
52astrocyte development (GO:0014002)3.30548760
53cerebellar granule cell differentiation (GO:0021707)3.29151628
54cell-cell signaling involved in cell fate commitment (GO:0045168)3.28315145
55membrane repolarization (GO:0086009)3.25083268
56positive regulation of neuroblast proliferation (GO:0002052)3.24812715
57positive regulation of cellular amide metabolic process (GO:0034250)3.23874458
58regulation of glomerular filtration (GO:0003093)3.23829070
59cellular sodium ion homeostasis (GO:0006883)3.22571247
60regulation of timing of cell differentiation (GO:0048505)3.20727362
61response to cholesterol (GO:0070723)3.18723412
62endocardial cushion morphogenesis (GO:0003203)3.17669710
63negative regulation of glial cell differentiation (GO:0045686)3.16944591
64axonal fasciculation (GO:0007413)3.16678984
65dermatan sulfate biosynthetic process (GO:0030208)3.16252283
66negative regulation of astrocyte differentiation (GO:0048712)3.12458698
67potassium ion import (GO:0010107)3.11269646
68establishment of nucleus localization (GO:0040023)3.11202531
69regulation of extracellular matrix organization (GO:1903053)3.09690712
70vocalization behavior (GO:0071625)3.08527281
71negative regulation of osteoblast proliferation (GO:0033689)3.08463497
72nephron tubule formation (GO:0072079)3.05957483
73neuron projection regeneration (GO:0031102)3.04886619
74dermatan sulfate metabolic process (GO:0030205)3.04672170
75cranial nerve development (GO:0021545)3.04287717
76neutral amino acid transport (GO:0015804)3.03258637
77axon regeneration (GO:0031103)3.03158974
78tongue development (GO:0043586)3.02763259
79regulation of membrane repolarization (GO:0060306)3.00378212
80regulation of inclusion body assembly (GO:0090083)2.99550084
81negative regulation of homotypic cell-cell adhesion (GO:0034111)2.99099444
82negative regulation of cardiac muscle tissue growth (GO:0055022)2.97853372
83negative regulation of heart growth (GO:0061117)2.97853372
84developmental induction (GO:0031128)2.93297083
85regulation of astrocyte differentiation (GO:0048710)2.92437793
86oligodendrocyte differentiation (GO:0048709)2.91808269
87negative regulation of synaptic transmission, GABAergic (GO:0032229)2.91595773
88acidic amino acid transport (GO:0015800)2.89536865
89eye photoreceptor cell differentiation (GO:0001754)2.89085140
90photoreceptor cell differentiation (GO:0046530)2.89085140
91renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.87460697
92regulation of tight junction assembly (GO:2000810)2.85574805
93glial cell proliferation (GO:0014009)2.85410196
94retinal ganglion cell axon guidance (GO:0031290)2.85130660
95mesenchyme morphogenesis (GO:0072132)2.83306213
96negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.83202380
97L-amino acid transport (GO:0015807)2.81262187
98glutamate receptor signaling pathway (GO:0007215)2.80553230
99negative regulation of smoothened signaling pathway (GO:0045879)2.80041507
100regulation of apoptotic cell clearance (GO:2000425)2.79679767
101negative regulation of platelet activation (GO:0010544)2.78395970
102phagocytosis, engulfment (GO:0006911)2.78039705
103long-chain fatty acid biosynthetic process (GO:0042759)2.77797407
104central nervous system myelination (GO:0022010)2.75440767
105axon ensheathment in central nervous system (GO:0032291)2.75440767
106positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.74812450
107neuron fate determination (GO:0048664)2.74515106
108regulation of cardiac muscle cell contraction (GO:0086004)2.74395668
109response to sterol (GO:0036314)2.73903831
110hyperosmotic salinity response (GO:0042538)2.73026410
111nonmotile primary cilium assembly (GO:0035058)2.72382075
112regulation of oligodendrocyte differentiation (GO:0048713)2.72210757
113peripheral nervous system neuron development (GO:0048935)2.71621162
114peripheral nervous system axon ensheathment (GO:0032292)2.70409456
115myelination in peripheral nervous system (GO:0022011)2.70409456
116regulation of development, heterochronic (GO:0040034)2.70270198
117tyrosine metabolic process (GO:0006570)2.70128406
118nucleotide transport (GO:0006862)2.69334877
119Notch signaling involved in heart development (GO:0061314)2.68883761
120pyrimidine nucleobase catabolic process (GO:0006208)2.68627698
121neurotransmitter-gated ion channel clustering (GO:0072578)2.68295592
122positive regulation of potassium ion transmembrane transport (GO:1901381)2.67738308
123neuronal action potential propagation (GO:0019227)2.67218929
124forebrain neuron differentiation (GO:0021879)2.65804010
125dendritic spine morphogenesis (GO:0060997)2.65113438
126G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.64052475
127neuron recognition (GO:0008038)2.63571722
128cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.63494349
129cell proliferation involved in metanephros development (GO:0072203)2.60133119
130renal system process involved in regulation of blood volume (GO:0001977)2.59878273
131regulation of cholesterol esterification (GO:0010872)2.59453408
132neuron projection extension involved in neuron projection guidance (GO:1902284)2.59171152
133axon extension involved in axon guidance (GO:0048846)2.59171152
134potassium ion homeostasis (GO:0055075)2.58840746
135epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.58778461
136innervation (GO:0060384)2.58149963
137regulation of beta-amyloid formation (GO:1902003)2.56479907
138potassium ion export (GO:0071435)2.56414915
139positive regulation of synapse assembly (GO:0051965)2.56236624
140membrane assembly (GO:0071709)2.54373197
141otic vesicle formation (GO:0030916)2.54177444
142* cGMP-mediated signaling (GO:0019934)2.53551226
143calcium-mediated signaling using intracellular calcium source (GO:0035584)2.52652561
144membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.52610766
145axon development (GO:0061564)2.52120957
146limb development (GO:0060173)2.50339382
147appendage development (GO:0048736)2.50339382
148positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.49682681
149regulation of alkaline phosphatase activity (GO:0010692)2.49511055
150cochlea development (GO:0090102)2.48584416
151chondroitin sulfate biosynthetic process (GO:0030206)2.48551864
152limb bud formation (GO:0060174)2.48238731
153mechanosensory behavior (GO:0007638)2.48211624
154locomotory exploration behavior (GO:0035641)2.47426052
155epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.47216919
156somatic stem cell division (GO:0048103)2.45470539
157lateral sprouting from an epithelium (GO:0060601)2.45152986
158negative regulation of chondrocyte differentiation (GO:0032331)2.44630407
159cellular response to reactive nitrogen species (GO:1902170)2.44375940
160regulation of integrin-mediated signaling pathway (GO:2001044)2.42785232
161negative regulation of tissue remodeling (GO:0034104)2.42619704
162regulation of endothelial cell chemotaxis (GO:2001026)2.42463848
163positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.41787176
164chondroitin sulfate metabolic process (GO:0030204)2.41728231
165midgut development (GO:0007494)2.41409020
166regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.41337415
167prepulse inhibition (GO:0060134)2.41164703
168acrosome reaction (GO:0007340)2.40681200

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.62141191
2EZH2_22144423_ChIP-Seq_EOC_Human3.28129394
3GBX2_23144817_ChIP-Seq_PC3_Human3.10237406
4AR_21572438_ChIP-Seq_LNCaP_Human2.93483901
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.85650242
6SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.72539867
7* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.71042266
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.48684959
9* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.47414478
10* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.41842563
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.32942316
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.31009543
13RBPJ_22232070_ChIP-Seq_NCS_Mouse2.25436216
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.25346510
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.25346510
16* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.22839991
17CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.22106780
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.01273096
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.01005911
20JARID2_20075857_ChIP-Seq_MESCs_Mouse1.98242737
21* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.90735591
22RNF2_27304074_Chip-Seq_ESCs_Mouse1.88553574
23CDX2_19796622_ChIP-Seq_MESCs_Mouse1.87430460
24* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.86182778
25TRIM28_21343339_ChIP-Seq_HEK293_Human1.80700459
26PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.77209328
27PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.77125349
28BCAT_22108803_ChIP-Seq_LS180_Human1.75763940
29* EZH2_27294783_Chip-Seq_ESCs_Mouse1.71121045
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.70242244
31CBX2_27304074_Chip-Seq_ESCs_Mouse1.70079809
32IKZF1_21737484_ChIP-ChIP_HCT116_Human1.68137028
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65981059
34TAF15_26573619_Chip-Seq_HEK293_Human1.64079227
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.62137129
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.62099745
37* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60908006
38* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59929075
39RXR_22108803_ChIP-Seq_LS180_Human1.56646448
40* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.55541528
41OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54225280
42* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.54206138
43* P300_19829295_ChIP-Seq_ESCs_Human1.53563927
44* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.52415455
45DROSHA_22980978_ChIP-Seq_HELA_Human1.49671363
46TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.48150286
47STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.44743068
48* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.44420250
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.44346716
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40996434
51CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.40811561
52NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.38548092
53EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.35982093
54TP53_18474530_ChIP-ChIP_U2OS_Human1.35680572
55ZFP57_27257070_Chip-Seq_ESCs_Mouse1.35548968
56SMAD4_21799915_ChIP-Seq_A2780_Human1.35095508
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33823614
58REST_21632747_ChIP-Seq_MESCs_Mouse1.33341576
59* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.32288080
60TP53_20018659_ChIP-ChIP_R1E_Mouse1.29327924
61ZNF217_24962896_ChIP-Seq_MCF-7_Human1.28602377
62* RING1B_27294783_Chip-Seq_ESCs_Mouse1.28344400
63AR_25329375_ChIP-Seq_VCAP_Human1.27754279
64SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26549950
65SOX9_26525672_Chip-Seq_HEART_Mouse1.26396339
66TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.26122405
67UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26025642
68WT1_19549856_ChIP-ChIP_CCG9911_Human1.25486373
69MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.23550131
70MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21705037
71FUS_26573619_Chip-Seq_HEK293_Human1.21261015
72AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20141412
73* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.20088058
74* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.20088058
75SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.19485385
76CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.17167958
77TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16296907
78NR3C1_23031785_ChIP-Seq_PC12_Mouse1.15750526
79ESR1_20079471_ChIP-ChIP_T-47D_Human1.15239565
80* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15057419
81TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14507461
82* ISL1_27105846_Chip-Seq_CPCs_Mouse1.14238349
83* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.14237464
84CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.14159862
85YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10837151
86RNF2_27304074_Chip-Seq_NSC_Mouse1.10265285
87POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09711612
88SOX2_21211035_ChIP-Seq_LN229_Gbm1.08668550
89ESR2_21235772_ChIP-Seq_MCF-7_Human1.08360676
90STAT3_23295773_ChIP-Seq_U87_Human1.08148999
91TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08046029
92POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.07863242
93NANOG_18555785_Chip-Seq_ESCs_Mouse1.07483373
94CLOCK_20551151_ChIP-Seq_293T_Human1.07242740
95CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.06838330
96TAL1_26923725_Chip-Seq_HPCs_Mouse1.06542758
97RUNX2_22187159_ChIP-Seq_PCA_Human1.05337585
98TBX3_20139965_ChIP-Seq_ESCs_Mouse1.04655144
99VDR_24787735_ChIP-Seq_THP-1_Human1.04490337
100RING1B_27294783_Chip-Seq_NPCs_Mouse1.04211920
101TBX3_20139965_ChIP-Seq_MESCs_Mouse1.04049125
102RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02723788
103TP53_16413492_ChIP-PET_HCT116_Human1.02166029
104TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01069516
105POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01069516
106TCF4_22108803_ChIP-Seq_LS180_Human1.00958442
107POU5F1_16518401_ChIP-PET_MESCs_Mouse1.00852988
108AR_19668381_ChIP-Seq_PC3_Human1.00302648
109SMAD4_21741376_ChIP-Seq_HESCs_Human0.99177991
110MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97390307
111ARNT_22903824_ChIP-Seq_MCF-7_Human0.96896305
112EP300_21415370_ChIP-Seq_HL-1_Mouse0.96276888
113* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.95736446
114JUN_21703547_ChIP-Seq_K562_Human0.95643587
115EWS_26573619_Chip-Seq_HEK293_Human0.94086847
116P53_22127205_ChIP-Seq_FIBROBLAST_Human0.93804762
117LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93287122
118FOXM1_26456572_ChIP-Seq_MCF-7_Human0.90877943
119SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.88702061
120* PRDM14_20953172_ChIP-Seq_ESCs_Human0.88058164
121MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.87557479
122SMAD3_21741376_ChIP-Seq_ESCs_Human0.87035913
123SMAD3_21741376_ChIP-Seq_HESCs_Human0.86384045
124CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86024196
125ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.85949373

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004858_abnormal_nervous_system5.67021302
2* MP0005171_absent_coat_pigmentation5.60583272
3MP0002254_reproductive_system_inflammat4.03475738
4* MP0003136_yellow_coat_color3.98288483
5MP0009384_cardiac_valve_regurgitation3.59358113
6MP0003690_abnormal_glial_cell3.47742541
7MP0004885_abnormal_endolymph3.05004017
8MP0000569_abnormal_digit_pigmentation2.89362252
9MP0003279_aneurysm2.74470411
10MP0003941_abnormal_skin_development2.70361612
11MP0005408_hypopigmentation2.48622580
12MP0005248_abnormal_Harderian_gland2.45143591
13MP0005409_darkened_coat_color2.43810519
14MP0002736_abnormal_nociception_after2.20629074
15MP0005257_abnormal_intraocular_pressure2.18278940
16MP0004272_abnormal_basement_membrane2.16047132
17MP0005167_abnormal_blood-brain_barrier2.13585449
18* MP0002095_abnormal_skin_pigmentation2.13393220
19MP0001984_abnormal_olfaction2.12644683
20MP0003634_abnormal_glial_cell2.08091940
21MP0000372_irregular_coat_pigmentation2.02444819
22MP0002653_abnormal_ependyma_morphology1.99564399
23MP0000015_abnormal_ear_pigmentation1.95737359
24MP0000371_diluted_coat_color1.91334134
25MP0003880_abnormal_central_pattern1.91094722
26MP0003075_altered_response_to1.90793309
27MP0009046_muscle_twitch1.87057885
28MP0001879_abnormal_lymphatic_vessel1.83738019
29MP0001968_abnormal_touch/_nociception1.78744517
30MP0001486_abnormal_startle_reflex1.76045927
31MP0002090_abnormal_vision1.75429962
32MP0003329_amyloid_beta_deposits1.75221329
33MP0002938_white_spotting1.74842135
34MP0004381_abnormal_hair_follicle1.72443508
35MP0005075_abnormal_melanosome_morpholog1.70966989
36MP0001958_emphysema1.69237965
37MP0002089_abnormal_postnatal_growth/wei1.68206714
38MP0003635_abnormal_synaptic_transmissio1.67884335
39MP0001542_abnormal_bone_strength1.66634449
40MP0004859_abnormal_synaptic_plasticity1.64146471
41MP0003633_abnormal_nervous_system1.60410952
42MP0005377_hearing/vestibular/ear_phenot1.60092951
43MP0003878_abnormal_ear_physiology1.60092951
44MP0001986_abnormal_taste_sensitivity1.59890148
45MP0005187_abnormal_penis_morphology1.58032492
46MP0005423_abnormal_somatic_nervous1.57546572
47MP0001485_abnormal_pinna_reflex1.47876448
48MP0000955_abnormal_spinal_cord1.46091571
49* MP0000026_abnormal_inner_ear1.43935786
50MP0001853_heart_inflammation1.42413138
51MP0009745_abnormal_behavioral_response1.42041438
52MP0000778_abnormal_nervous_system1.40000576
53MP0001440_abnormal_grooming_behavior1.38835671
54MP0001502_abnormal_circadian_rhythm1.36995370
55MP0003011_delayed_dark_adaptation1.33625199
56MP0003646_muscle_fatigue1.33600867
57* MP0001324_abnormal_eye_pigmentation1.33321896
58MP0002572_abnormal_emotion/affect_behav1.30363424
59MP0000920_abnormal_myelination1.26767410
60MP0002638_abnormal_pupillary_reflex1.26565114
61MP0002064_seizures1.26312646
62MP0002067_abnormal_sensory_capabilities1.24794325
63MP0002063_abnormal_learning/memory/cond1.23440135
64MP0000049_abnormal_middle_ear1.21613453
65* MP0005174_abnormal_tail_pigmentation1.20351029
66MP0000604_amyloidosis1.18008820
67MP0005165_increased_susceptibility_to1.17777134
68MP0004883_abnormal_blood_vessel1.17094639
69MP0004270_analgesia1.16660123
70MP0004233_abnormal_muscle_weight1.15480109
71* MP0002075_abnormal_coat/hair_pigmentati1.14398504
72* MP0003631_nervous_system_phenotype1.13023342
73MP0005166_decreased_susceptibility_to1.12101917
74MP0004215_abnormal_myocardial_fiber1.11909611
75MP0006138_congestive_heart_failure1.11754764
76MP0009780_abnormal_chondrocyte_physiolo1.10749162
77MP0005623_abnormal_meninges_morphology1.10213003
78MP0005645_abnormal_hypothalamus_physiol1.08947872
79MP0001915_intracranial_hemorrhage1.08408717
80MP0002557_abnormal_social/conspecific_i1.07800475
81MP0008569_lethality_at_weaning1.07224022
82MP0004142_abnormal_muscle_tone1.02696556
83MP0001299_abnormal_eye_distance/1.01483417
84MP0005503_abnormal_tendon_morphology1.01024583
85MP0005332_abnormal_amino_acid0.98470281
86MP0005391_vision/eye_phenotype0.97092459
87MP0002909_abnormal_adrenal_gland0.95233804
88MP0005646_abnormal_pituitary_gland0.93415163
89MP0002972_abnormal_cardiac_muscle0.91989619
90MP0001529_abnormal_vocalization0.90574216
91* MP0001186_pigmentation_phenotype0.90369104
92MP0003137_abnormal_impulse_conducting0.89821255
93MP0002735_abnormal_chemical_nociception0.88960652
94MP0000566_synostosis0.88199131
95MP0002822_catalepsy0.86816505
96MP0000750_abnormal_muscle_regeneration0.86062070
97MP0005195_abnormal_posterior_eye0.85894208
98* MP0002882_abnormal_neuron_morphology0.85436692
99MP0002127_abnormal_cardiovascular_syste0.84788237
100MP0002733_abnormal_thermal_nociception0.84503208
101MP0002734_abnormal_mechanical_nocicepti0.81978063
102MP0004133_heterotaxia0.81807561
103MP0005164_abnormal_response_to0.81566738
104MP0000762_abnormal_tongue_morphology0.80748049
105MP0001501_abnormal_sleep_pattern0.80492550
106MP0004134_abnormal_chest_morphology0.80470587
107MP0005551_abnormal_eye_electrophysiolog0.80340941
108MP0004742_abnormal_vestibular_system0.80150165
109MP0004043_abnormal_pH_regulation0.79868409
110MP0005253_abnormal_eye_physiology0.79462643
111MP0005670_abnormal_white_adipose0.79323823
112* MP0001963_abnormal_hearing_physiology0.79320293
113MP0000767_abnormal_smooth_muscle0.79124573
114MP0003950_abnormal_plasma_membrane0.79070880
115MP0003283_abnormal_digestive_organ0.78687599
116MP0001177_atelectasis0.78103762
117* MP0005595_abnormal_vascular_smooth0.76895519
118MP0000631_abnormal_neuroendocrine_gland0.76512822
119MP0010368_abnormal_lymphatic_system0.76442214
120MP0004085_abnormal_heartbeat0.76137006
121* MP0001970_abnormal_pain_threshold0.75607420
122* MP0002752_abnormal_somatic_nervous0.75203898
123MP0003045_fibrosis0.75083630
124MP0005197_abnormal_uvea_morphology0.74745750
125MP0006072_abnormal_retinal_apoptosis0.73546321
126MP0001293_anophthalmia0.72272521
127* MP0003632_abnormal_nervous_system0.71896423
128MP0000428_abnormal_craniofacial_morphol0.70220850
129MP0002249_abnormal_larynx_morphology0.69977063
130MP0002697_abnormal_eye_size0.69816638
131MP0004924_abnormal_behavior0.69738772
132MP0005386_behavior/neurological_phenoty0.69738772
133MP0010030_abnormal_orbit_morphology0.69698526
134MP0009250_abnormal_appendicular_skeleto0.69622175
135MP0002272_abnormal_nervous_system0.69463115
136MP0001905_abnormal_dopamine_level0.69196840
137MP0002295_abnormal_pulmonary_circulatio0.68176303
138MP0002102_abnormal_ear_morphology0.66947808
139MP0002877_abnormal_melanocyte_morpholog0.66116515
140MP0002282_abnormal_trachea_morphology0.66082579
141MP0002092_abnormal_eye_morphology0.65309488
142MP0000534_abnormal_ureter_morphology0.65011338
143MP0000383_abnormal_hair_follicle0.64745059
144MP0000647_abnormal_sebaceous_gland0.64462752
145* MP0002152_abnormal_brain_morphology0.64092772

Predicted human phenotypes

RankGene SetZ-score
1Aplasia involving bones of the upper limbs (HP:0009823)5.87734098
2Aplasia of the phalanges of the hand (HP:0009802)5.87734098
3Aplasia involving bones of the extremities (HP:0009825)5.87734098
4Short middle phalanx of the 5th finger (HP:0004220)5.12332036
5Hypoplastic left heart (HP:0004383)5.00977280
6Megalencephaly (HP:0001355)4.70074615
7* White forelock (HP:0002211)4.62368161
8* Patchy hypopigmentation of hair (HP:0011365)4.37437897
9Septo-optic dysplasia (HP:0100842)3.83356074
10* Blue irides (HP:0000635)3.81020318
11Hemiplegia (HP:0002301)3.73534708
12Hypoplastic heart (HP:0001961)3.64899355
13Hemiparesis (HP:0001269)3.57576598
14Abnormality of the diencephalon (HP:0010662)3.50466294
15Arterial tortuosity (HP:0005116)3.49523279
16Tetraparesis (HP:0002273)3.46608264
17Myelomeningocele (HP:0002475)3.44241456
18Polyphagia (HP:0002591)3.43026462
19Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)3.39509388
20Vascular tortuosity (HP:0004948)3.38324982
21Absent hair (HP:0002298)3.24992287
22Absent eyelashes (HP:0000561)3.15031708
23Congenital sensorineural hearing impairment (HP:0008527)3.13228118
24Abnormality of the middle phalanx of the 5th finger (HP:0004219)3.10258781
25Hypoplasia of the iris (HP:0007676)3.04258492
26Aplasia/Hypoplasia of the 5th finger (HP:0006262)3.04026084
27Broad alveolar ridges (HP:0000187)3.02906555
28Focal motor seizures (HP:0011153)3.02828570
29Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)3.02777135
30Maternal diabetes (HP:0009800)3.01688358
31Abnormality of secondary sexual hair (HP:0009888)3.01644904
32Abnormality of the axillary hair (HP:0100134)3.01644904
33Morphological abnormality of the middle ear (HP:0008609)3.01618948
34Abnormality of the fovea (HP:0000493)2.99366570
35Long nose (HP:0003189)2.98294163
36Esophageal atresia (HP:0002032)2.98187743
37Aplasia/Hypoplasia of the macula (HP:0008059)2.97204478
38Diplopia (HP:0000651)2.97202876
39Abnormality of binocular vision (HP:0011514)2.97202876
40Mixed hearing impairment (HP:0000410)2.94587231
41Short hallux (HP:0010109)2.91942754
42Synostosis involving the elbow (HP:0003938)2.89511733
43Humeroradial synostosis (HP:0003041)2.89511733
44Absent eyebrow (HP:0002223)2.88085628
45Bifid tongue (HP:0010297)2.86989265
46Narrow nasal bridge (HP:0000446)2.86744054
47Midline defect of the nose (HP:0004122)2.84800777
48Submucous cleft hard palate (HP:0000176)2.82796745
49Abnormality of the phalanges of the 5th finger (HP:0004213)2.80863321
50Alacrima (HP:0000522)2.79907260
51Cutaneous syndactyly (HP:0012725)2.78341479
52Pheochromocytoma (HP:0002666)2.75779610
53Aplasia/Hypoplasia affecting the retina (HP:0008061)2.75162177
54Supernumerary ribs (HP:0005815)2.73266753
55Abnormality of the ischium (HP:0003174)2.72442933
56Gastrointestinal atresia (HP:0002589)2.70565305
57Coronal craniosynostosis (HP:0004440)2.69529672
58Hypoplastic pelvis (HP:0008839)2.63399932
59Ulnar claw (HP:0001178)2.59406011
60Aplasia/Hypoplasia of the hallux (HP:0008362)2.57022181
61Ocular albinism (HP:0001107)2.56994343
62Spondylolisthesis (HP:0003302)2.56855342
63Peripheral hypomyelination (HP:0007182)2.56138446
64Neurofibrillary tangles (HP:0002185)2.55713437
65Slow-growing hair (HP:0002217)2.53056432
66Abnormality of hair growth rate (HP:0011363)2.53056432
67True hermaphroditism (HP:0010459)2.52957708
68Spastic diplegia (HP:0001264)2.52833559
69Abnormality of the 4th metacarpal (HP:0010012)2.52137794
70Selective tooth agenesis (HP:0001592)2.50726678
71Striae distensae (HP:0001065)2.50269321
72Meningocele (HP:0002435)2.49210309
73Split foot (HP:0001839)2.48665796
74Dry hair (HP:0011359)2.47398455
75Large earlobe (HP:0009748)2.46747033
76Supernumerary bones of the axial skeleton (HP:0009144)2.45770797
77Hemivertebrae (HP:0002937)2.44744721
78* Heterochromia iridis (HP:0001100)2.44239707
79Neonatal short-limb short stature (HP:0008921)2.43666098
80Oligodactyly (hands) (HP:0001180)2.42212206
81Prenatal maternal abnormality (HP:0002686)2.41915719
82Abnormal eating behavior (HP:0100738)2.41800478
83Aortic dissection (HP:0002647)2.39408236
84Vertebral hypoplasia (HP:0008417)2.38777291
85Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.38777291
86Neoplasm of the heart (HP:0100544)2.38132440
87Iris hypopigmentation (HP:0007730)2.38123202
88Neuroendocrine neoplasm (HP:0100634)2.34644638
89Progressive cerebellar ataxia (HP:0002073)2.32548698
90Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.30381094
91Short 4th metacarpal (HP:0010044)2.30381094
92Round ear (HP:0100830)2.29565444
93Aortic aneurysm (HP:0004942)2.28190705
94Decreased lacrimation (HP:0000633)2.28126840
95Aplasia/Hypoplasia of the clavicles (HP:0006710)2.28013449
96Action tremor (HP:0002345)2.27824819
97Morphological abnormality of the inner ear (HP:0011390)2.25819893
98Median cleft lip (HP:0000161)2.23231346
99Anophthalmia (HP:0000528)2.22848508
100Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.22377280
101Fibular hypoplasia (HP:0003038)2.21856494
102Onycholysis (HP:0001806)2.17589665
103Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.14864257
104Abnormality of the dental pulp (HP:0006479)2.14096836
105Hypoplasia of the fovea (HP:0007750)2.13674002
106Aplasia/Hypoplasia of the fovea (HP:0008060)2.13674002
107Short 5th finger (HP:0009237)2.11606094
108Fibular aplasia (HP:0002990)2.10246832
109Rib fusion (HP:0000902)2.09751888
110Cutaneous finger syndactyly (HP:0010554)2.08507147
111Broad foot (HP:0001769)2.07986374
112Bilateral microphthalmos (HP:0007633)2.07758574
113Short palpebral fissure (HP:0012745)2.06683891
114Toxemia of pregnancy (HP:0100603)2.03802882
115Abnormality of chromosome segregation (HP:0002916)2.02656058
116Neoplasm of the oral cavity (HP:0100649)2.02606454
117Hamartoma (HP:0010566)2.00494330
118Optic nerve hypoplasia (HP:0000609)2.00250627
119Pulmonary artery stenosis (HP:0004415)1.98815573
120Multifactorial inheritance (HP:0001426)1.98598201
121Protrusio acetabuli (HP:0003179)1.98215809
122Cerebral inclusion bodies (HP:0100314)1.95274252
123Adrenal hypoplasia (HP:0000835)1.95088738
124Blepharitis (HP:0000498)1.94080970
125Absent toe (HP:0010760)1.93346908
126Abnormality of the dental root (HP:0006486)1.92238645
127Taurodontia (HP:0000679)1.92238645
128Abnormality of permanent molar morphology (HP:0011071)1.92238645
129Atrioventricular canal defect (HP:0006695)1.90826807
130Clumsiness (HP:0002312)1.90615916
131Trigonocephaly (HP:0000243)1.90129842
132Adactyly (HP:0009776)1.89957098
133Steppage gait (HP:0003376)1.88352649
134Polygenic inheritance (HP:0010982)1.87639295
135Abnormality of the pubic bones (HP:0003172)1.87486207
136Postural tremor (HP:0002174)1.87215723
137Neoplasm of the peripheral nervous system (HP:0100007)1.85769963
138Hepatoblastoma (HP:0002884)1.85122377
139Abnormality of molar (HP:0011077)1.84314737
140Abnormality of molar morphology (HP:0011070)1.84314737
141Absent septum pellucidum (HP:0001331)1.83918676
142Atrioventricular block (HP:0001678)1.83631889
143Cortical dysplasia (HP:0002539)1.83202415
144Abnormality of the middle phalanges of the toes (HP:0010183)1.83145412
145Wide anterior fontanel (HP:0000260)1.83128213
146Aplasia/Hypoplasia of the fibula (HP:0006492)1.82403065
147Aplasia/Hypoplasia of the sternum (HP:0006714)1.81539719
148Hammertoe (HP:0001765)1.81273948
149Skull defect (HP:0001362)1.81026221
150Vertebral clefting (HP:0008428)1.80227881
151Gait imbalance (HP:0002141)1.80014327
152Renal tubular acidosis (HP:0001947)1.79572844
153Tarsal synostosis (HP:0008368)1.79458473
154Truncal ataxia (HP:0002078)1.79241395
155Partial duplication of thumb phalanx (HP:0009944)1.78715006
156Synostosis of carpal bones (HP:0005048)1.78427095
157Generalized tonic-clonic seizures (HP:0002069)1.77652859
158* Hypopigmentation of the fundus (HP:0007894)1.77043589
159Turricephaly (HP:0000262)1.76960485
160Genital tract atresia (HP:0001827)1.76928935
161Bronchomalacia (HP:0002780)1.74997038
162Abnormality of the anterior chamber (HP:0000593)1.74383731
163Aplasia/Hypoplasia of the scapulae (HP:0006713)1.74214713
164Hypoplastic scapulae (HP:0000882)1.74214713
165Atonic seizures (HP:0010819)1.74107497
166Broad face (HP:0000283)1.73838239
167Abnormal sex determination (HP:0012244)1.73735199
168Sex reversal (HP:0012245)1.73735199
169Abnormality of glycine metabolism (HP:0010895)1.73339573
170Abnormality of serine family amino acid metabolism (HP:0010894)1.73339573
171Synostosis involving bones of the lower limbs (HP:0009138)1.73253359
172Vaginal atresia (HP:0000148)1.71775379
173Shallow orbits (HP:0000586)1.70637030
174Short tibia (HP:0005736)1.70155579

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRKD37.38170367
2PNCK4.71498315
3LMTK24.26964221
4MAPK154.15107438
5TNIK3.55555893
6AKT33.51362971
7WEE13.25982468
8CDK83.09964062
9EPHA33.07971628
10PHKG22.91359586
11PHKG12.91359586
12TSSK62.84576046
13NTRK22.67411545
14MAP2K72.39430679
15MAPK132.31512983
16SGK22.20788559
17CASK2.08032725
18MAP3K41.89446684
19TYRO31.82185058
20SGK2231.72581039
21SGK4941.72581039
22SGK31.69009231
23MAPK121.68172309
24CSNK1G21.65860133
25MAP3K61.60329803
26DDR21.48605638
27CDK31.48545431
28PRKCH1.46488949
29FGFR21.46226202
30MAPK71.34966825
31EPHB21.34005612
32PRKCE1.28959615
33PRKD21.25829084
34BMPR1B1.23938581
35NEK91.21242206
36WNK31.17101198
37MARK11.16679813
38ERBB21.16192803
39SIK11.14821574
40BRAF1.14703547
41ARAF1.12411218
42MUSK1.11425715
43DYRK21.11009467
44PLK21.08706097
45CSNK1G11.08529405
46MAP3K71.07195799
47TIE11.01927473
48FER1.00596415
49CSNK1G30.98501401
50EPHA40.97866428
51IRAK20.97378191
52PRKCG0.97031349
53STK390.95766477
54ALK0.95561926
55CSNK1A1L0.94889463
56PKN10.87398261
57MAP2K40.84618735
58PINK10.84212104
59IGF1R0.83675259
60ILK0.82468174
61MKNK10.82116038
62STK38L0.78458669
63CAMK2D0.77325905
64MOS0.76981100
65GSK3A0.74769193
66CDK90.74591857
67PDGFRA0.74491300
68BCR0.73862982
69MELK0.72990064
70UHMK10.72930365
71EPHB10.70481418
72MINK10.70204127
73PTK60.70173657
74PRKCQ0.67778485
75SGK10.67284281
76DYRK1A0.67229756
77TAOK20.66989621
78ROCK20.66023481
79CAMK2B0.65601228
80FGR0.64627063
81NEK60.63952815
82MET0.63399918
83NTRK30.63188359
84PAK20.62971783
85NTRK10.59565558
86TRIB30.59471926
87PDGFRB0.59399783
88ERBB40.58854698
89IRAK10.58603441
90ERBB30.58179766
91VRK10.56057869
92PRKD10.55614450
93WNK40.55594107
94ROCK10.54156952
95PTK2B0.54137932
96PRKAA20.54123600
97TGFBR10.52918253
98PAK30.51693779
99PRKCZ0.51495017
100MAP3K50.48063345
101LATS20.47988740
102PDK20.47902222
103STK240.47130630
104CDK50.46920551
105INSRR0.46576197
106MARK30.46169188
107FES0.45559732
108MAPKAPK50.44630985
109RET0.42706890
110ADRBK10.42472664
111PRKCD0.41732013
112NLK0.41018813
113AKT20.40815801
114SRC0.40387706
115LATS10.39895618
116DMPK0.39059883
117BMX0.38903384
118NUAK10.38855556
119CAMK2G0.38528552
120KSR10.38489375
121CAMK2A0.37655700
122INSR0.36897350
123DYRK1B0.36885985
124TGFBR20.35879251
125PRKACG0.35514079
126PIK3CA0.35279356
127BCKDK0.33860983
128PLK30.32951823
129CDK150.31360798
130PRKG10.30932741
131PRKACB0.30659519
132CDK180.30223185
133CDK11A0.30061874
134PAK60.29946689
135CAMK1G0.29933517
136MYLK0.29880043
137CAMK1D0.29641806
138PRKCA0.29551180
139CSNK1D0.28485227
140YES10.28476527
141MKNK20.27840210
142RIPK10.27227436
143MAPK100.26985889
144FGFR10.26099682
145PIM20.25644943
146HCK0.25355384

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.70254164
2Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049644.01570129
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.55518510
4Fatty acid biosynthesis_Homo sapiens_hsa000612.50678590
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.39688710
6Steroid biosynthesis_Homo sapiens_hsa001002.32903236
7Fatty acid metabolism_Homo sapiens_hsa012122.18512905
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.16837913
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.09195269
10GABAergic synapse_Homo sapiens_hsa047271.79219018
11Nicotine addiction_Homo sapiens_hsa050331.78273534
12Fatty acid degradation_Homo sapiens_hsa000711.77126274
13PPAR signaling pathway_Homo sapiens_hsa033201.67489060
14Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.65096707
15Bile secretion_Homo sapiens_hsa049761.59992391
16Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.58942108
17Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.55608018
18Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.48562764
19Glutamatergic synapse_Homo sapiens_hsa047241.43585501
20Primary bile acid biosynthesis_Homo sapiens_hsa001201.42161416
21Notch signaling pathway_Homo sapiens_hsa043301.40338283
22Vitamin B6 metabolism_Homo sapiens_hsa007501.35801972
23Tyrosine metabolism_Homo sapiens_hsa003501.35207282
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.32352608
25Cocaine addiction_Homo sapiens_hsa050301.29205951
26Salivary secretion_Homo sapiens_hsa049701.25583872
27Basal cell carcinoma_Homo sapiens_hsa052171.25076894
28Fatty acid elongation_Homo sapiens_hsa000621.23180011
29Gastric acid secretion_Homo sapiens_hsa049711.20421605
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.19158805
31Butanoate metabolism_Homo sapiens_hsa006501.15551068
32Estrogen signaling pathway_Homo sapiens_hsa049151.14641315
33Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.13142391
34Propanoate metabolism_Homo sapiens_hsa006401.12032924
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.10690154
36Morphine addiction_Homo sapiens_hsa050321.07343486
37Sulfur metabolism_Homo sapiens_hsa009201.07059496
38Circadian entrainment_Homo sapiens_hsa047131.04065026
39Taste transduction_Homo sapiens_hsa047421.02202135
40AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.98833696
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.98757121
42Complement and coagulation cascades_Homo sapiens_hsa046100.96273713
43Insulin secretion_Homo sapiens_hsa049110.95430219
44Renin secretion_Homo sapiens_hsa049240.94771976
45Arginine and proline metabolism_Homo sapiens_hsa003300.93684516
46Dilated cardiomyopathy_Homo sapiens_hsa054140.93191398
47Gap junction_Homo sapiens_hsa045400.93029448
48Vitamin digestion and absorption_Homo sapiens_hsa049770.91985379
49Hedgehog signaling pathway_Homo sapiens_hsa043400.91777645
50Dorso-ventral axis formation_Homo sapiens_hsa043200.91562323
51Long-term depression_Homo sapiens_hsa047300.89654910
52Protein digestion and absorption_Homo sapiens_hsa049740.88745029
53TGF-beta signaling pathway_Homo sapiens_hsa043500.87920889
54ECM-receptor interaction_Homo sapiens_hsa045120.84615980
55Amphetamine addiction_Homo sapiens_hsa050310.84470683
56Dopaminergic synapse_Homo sapiens_hsa047280.84166770
57Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83280570
58Axon guidance_Homo sapiens_hsa043600.82269989
59Circadian rhythm_Homo sapiens_hsa047100.80881560
60* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80389505
61cAMP signaling pathway_Homo sapiens_hsa040240.80198570
62Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.79339469
63* Calcium signaling pathway_Homo sapiens_hsa040200.78062515
64Adherens junction_Homo sapiens_hsa045200.76197713
65ABC transporters_Homo sapiens_hsa020100.75462857
66Mineral absorption_Homo sapiens_hsa049780.75008073
67Ether lipid metabolism_Homo sapiens_hsa005650.74955429
68Long-term potentiation_Homo sapiens_hsa047200.74789002
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74286060
70Pancreatic secretion_Homo sapiens_hsa049720.73882128
71Focal adhesion_Homo sapiens_hsa045100.73109418
72* Melanogenesis_Homo sapiens_hsa049160.72942323
73Malaria_Homo sapiens_hsa051440.72776703
74Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.72648382
75Colorectal cancer_Homo sapiens_hsa052100.72569621
76Tight junction_Homo sapiens_hsa045300.72083406
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.71164781
78Wnt signaling pathway_Homo sapiens_hsa043100.71063594
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70297929
80Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.70067983
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.70017621
82Rap1 signaling pathway_Homo sapiens_hsa040150.69314165
83Endometrial cancer_Homo sapiens_hsa052130.68836026
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67718853
85Protein export_Homo sapiens_hsa030600.67642087
86Thyroid hormone synthesis_Homo sapiens_hsa049180.66999197
87Cardiac muscle contraction_Homo sapiens_hsa042600.64205771
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.63769163
89Staphylococcus aureus infection_Homo sapiens_hsa051500.63505245
90beta-Alanine metabolism_Homo sapiens_hsa004100.62379075
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61605154
92Phototransduction_Homo sapiens_hsa047440.59814124
93Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59743838
94Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.59625466
95Olfactory transduction_Homo sapiens_hsa047400.56895534
96Proteoglycans in cancer_Homo sapiens_hsa052050.56213880
97Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55790662
98Melanoma_Homo sapiens_hsa052180.55677338
99Glycosaminoglycan degradation_Homo sapiens_hsa005310.55633457
100Cholinergic synapse_Homo sapiens_hsa047250.55183442
101Glioma_Homo sapiens_hsa052140.54686412
102Folate biosynthesis_Homo sapiens_hsa007900.54612195
103Ovarian steroidogenesis_Homo sapiens_hsa049130.54378751
104Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.54189960
105Glycerolipid metabolism_Homo sapiens_hsa005610.53892645
106Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52526744
107Arginine biosynthesis_Homo sapiens_hsa002200.52406031
108Pyruvate metabolism_Homo sapiens_hsa006200.52206271
109Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.51833686
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51696791
111Serotonergic synapse_Homo sapiens_hsa047260.50918757
112Pancreatic cancer_Homo sapiens_hsa052120.49821168
113Peroxisome_Homo sapiens_hsa041460.49247454
114Non-small cell lung cancer_Homo sapiens_hsa052230.48072211
115Prion diseases_Homo sapiens_hsa050200.48041951
116Renin-angiotensin system_Homo sapiens_hsa046140.47840097
117Tryptophan metabolism_Homo sapiens_hsa003800.47191186
118Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47137326
119alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47084015
120Aldosterone synthesis and secretion_Homo sapiens_hsa049250.46936619
121Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46130997
122Insulin resistance_Homo sapiens_hsa049310.45712673
123Lysosome_Homo sapiens_hsa041420.45140802
124Lysine degradation_Homo sapiens_hsa003100.44877061
125Vascular smooth muscle contraction_Homo sapiens_hsa042700.44065262
126Hippo signaling pathway_Homo sapiens_hsa043900.43327017
127Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.43130931
128ErbB signaling pathway_Homo sapiens_hsa040120.42660267
129* cGMP-PKG signaling pathway_Homo sapiens_hsa040220.42602544
130Cysteine and methionine metabolism_Homo sapiens_hsa002700.41822305
131African trypanosomiasis_Homo sapiens_hsa051430.41739741
132MicroRNAs in cancer_Homo sapiens_hsa052060.41172673
133Histidine metabolism_Homo sapiens_hsa003400.40203107
134Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.39961041
135Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39457162

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