EEF1A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas, and the other isoform (alpha 2) is expressed in brain, heart and skeletal muscle. This isoform is identified as an autoantigen in 66% of patients with Felty syndrome. This gene has been found to have multiple copies on many chromosomes, some of which, if not all, represent different pseudogenes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.49859739
2ribosomal small subunit assembly (GO:0000028)5.48368479
3viral transcription (GO:0019083)4.88632343
4translational termination (GO:0006415)4.75682584
5maturation of SSU-rRNA (GO:0030490)4.46388619
6* translational elongation (GO:0006414)4.25148985
7nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.19482611
8DNA strand elongation involved in DNA replication (GO:0006271)4.11522159
9formation of translation preinitiation complex (GO:0001731)4.10178458
10protein localization to kinetochore (GO:0034501)4.06922161
11protein targeting to membrane (GO:0006612)4.05170178
12nuclear pore organization (GO:0006999)4.00615576
13translational initiation (GO:0006413)3.99621604
14DNA strand elongation (GO:0022616)3.92187394
15nuclear pore complex assembly (GO:0051292)3.90536712
16ribosomal small subunit biogenesis (GO:0042274)3.90097720
17IMP biosynthetic process (GO:0006188)3.86883419
18SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.84106060
19DNA replication initiation (GO:0006270)3.83315531
20mitotic nuclear envelope disassembly (GO:0007077)3.78000994
21regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.76751512
22folic acid-containing compound biosynthetic process (GO:0009396)3.75376796
23cellular protein complex disassembly (GO:0043624)3.74668641
24viral life cycle (GO:0019058)3.73540565
25protein targeting to ER (GO:0045047)3.73411344
26cotranslational protein targeting to membrane (GO:0006613)3.72379864
27negative regulation of DNA repair (GO:0045738)3.72316357
28protein complex disassembly (GO:0043241)3.55873551
29establishment of protein localization to endoplasmic reticulum (GO:0072599)3.55744045
30DNA duplex unwinding (GO:0032508)3.55741454
31membrane disassembly (GO:0030397)3.54002397
32nuclear envelope disassembly (GO:0051081)3.54002397
33ribosomal large subunit biogenesis (GO:0042273)3.53972039
34DNA geometric change (GO:0032392)3.53454710
35telomere maintenance via semi-conservative replication (GO:0032201)3.51239221
36negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.50637491
37negative regulation of RNA splicing (GO:0033119)3.48155345
38* translation (GO:0006412)3.46856797
39nucleobase biosynthetic process (GO:0046112)3.45328908
40IMP metabolic process (GO:0046040)3.43374343
41protein localization to endoplasmic reticulum (GO:0070972)3.42973047
42establishment of viral latency (GO:0019043)3.40856865
43protein localization to chromosome, centromeric region (GO:0071459)3.35887315
44DNA replication-dependent nucleosome organization (GO:0034723)3.33420573
45DNA replication-dependent nucleosome assembly (GO:0006335)3.33420573
46macromolecular complex disassembly (GO:0032984)3.30032051
47nuclear-transcribed mRNA catabolic process (GO:0000956)3.28703261
48mitotic chromosome condensation (GO:0007076)3.19593134
49mitotic recombination (GO:0006312)3.19509375
50ribonucleoprotein complex biogenesis (GO:0022613)3.15657102
51negative regulation of histone methylation (GO:0031061)3.14647403
52sister chromatid segregation (GO:0000819)3.13773673
53telomere maintenance via recombination (GO:0000722)3.13701407
54mRNA catabolic process (GO:0006402)3.11590643
55dosage compensation (GO:0007549)3.10861798
56mitotic sister chromatid cohesion (GO:0007064)3.09519585
57regulation of histone H3-K9 methylation (GO:0051570)3.09484460
58regulation of translational fidelity (GO:0006450)3.09298520
59alternative mRNA splicing, via spliceosome (GO:0000380)3.08403182
60RNA catabolic process (GO:0006401)3.06675500
61heterochromatin organization (GO:0070828)3.02547327
62regulation of RNA export from nucleus (GO:0046831)3.02465907
63translesion synthesis (GO:0019985)3.02154639
64telomere maintenance via telomere lengthening (GO:0010833)2.97476967
65mitotic sister chromatid segregation (GO:0000070)2.97077494
66pre-miRNA processing (GO:0031054)2.96261912
67negative regulation of mRNA processing (GO:0050686)2.94927732
68regulation of spindle organization (GO:0090224)2.93739824
69regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.93529538
70DNA topological change (GO:0006265)2.92623864
71pore complex assembly (GO:0046931)2.92603335
72nucleotide-excision repair, DNA gap filling (GO:0006297)2.90976685
73mRNA splicing, via spliceosome (GO:0000398)2.89057200
74RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.89057200
75purine nucleobase biosynthetic process (GO:0009113)2.88678661
76DNA ligation (GO:0006266)2.88570875
77mitotic metaphase plate congression (GO:0007080)2.88298658
78RNA splicing, via transesterification reactions (GO:0000375)2.86360909
79peptidyl-arginine omega-N-methylation (GO:0035247)2.85132929
80DNA conformation change (GO:0071103)2.84391559
81ribosome assembly (GO:0042255)2.82097644
82V(D)J recombination (GO:0033151)2.80506463
83regulation of sister chromatid cohesion (GO:0007063)2.80371481
84double-strand break repair via nonhomologous end joining (GO:0006303)2.79464256
85non-recombinational repair (GO:0000726)2.79464256
86ribosome biogenesis (GO:0042254)2.79085840
87ribonucleoprotein complex assembly (GO:0022618)2.77978822
88nuclear envelope organization (GO:0006998)2.75803345
893-UTR-mediated mRNA stabilization (GO:0070935)2.74933062
90DNA replication-independent nucleosome assembly (GO:0006336)2.73395850
91DNA replication-independent nucleosome organization (GO:0034724)2.73395850
92protein complex localization (GO:0031503)2.73259326
93regulation of gene silencing by RNA (GO:0060966)2.71994105
94regulation of posttranscriptional gene silencing (GO:0060147)2.71994105
95regulation of gene silencing by miRNA (GO:0060964)2.71994105
96postreplication repair (GO:0006301)2.70790013
97nucleosome disassembly (GO:0006337)2.70561181
98protein-DNA complex disassembly (GO:0032986)2.70561181
99ATP-dependent chromatin remodeling (GO:0043044)2.70469412
100negative regulation of mRNA metabolic process (GO:1903312)2.70171804
101metaphase plate congression (GO:0051310)2.70109254
102chromatin assembly or disassembly (GO:0006333)2.70050926
103regulation of translational initiation (GO:0006446)2.68561869
104chromatin assembly (GO:0031497)2.67934670
105rRNA processing (GO:0006364)2.66937638
106somatic diversification of immune receptors via somatic mutation (GO:0002566)2.66243802
107somatic hypermutation of immunoglobulin genes (GO:0016446)2.66243802
108establishment of chromosome localization (GO:0051303)2.66094244
109establishment of protein localization to membrane (GO:0090150)2.64853742
110establishment of integrated proviral latency (GO:0075713)2.64512839
111regulation of histone H3-K27 methylation (GO:0061085)2.64314001
112protein localization to chromosome (GO:0034502)2.64054687
113DNA replication checkpoint (GO:0000076)2.63498331
114ribonucleoprotein complex subunit organization (GO:0071826)2.62896064
115regulation of translational termination (GO:0006449)2.62232450
116histone H2A monoubiquitination (GO:0035518)2.61700532
117CENP-A containing nucleosome assembly (GO:0034080)2.61520406
118RNA stabilization (GO:0043489)2.60907231
119mRNA stabilization (GO:0048255)2.60907231
120spliceosomal tri-snRNP complex assembly (GO:0000244)2.60750263
121chromatin remodeling at centromere (GO:0031055)2.60667285
122protein export from nucleus (GO:0006611)2.58225522
123* gene expression (GO:0010467)2.56733639
124cellular protein complex localization (GO:0034629)2.55667300
125L-serine metabolic process (GO:0006563)2.52753772

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.15480843
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.32138694
3* MYC_18555785_ChIP-Seq_MESCs_Mouse4.05572980
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.56375154
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.51178397
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.32934786
7* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.03192901
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.94247474
9MYC_22102868_ChIP-Seq_BL_Human2.87927007
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.51348656
11* XRN2_22483619_ChIP-Seq_HELA_Human2.33972553
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.29757192
13* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.18812938
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.14292832
15AR_21909140_ChIP-Seq_LNCAP_Human2.01497980
16ETS1_20019798_ChIP-Seq_JURKAT_Human1.97508254
17E2F1_21310950_ChIP-Seq_MCF-7_Human1.96034176
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.92635100
19KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.89791888
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.83392276
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.80997357
22* CIITA_25753668_ChIP-Seq_RAJI_Human1.79846267
23CREB1_15753290_ChIP-ChIP_HEK293T_Human1.77907161
24GABP_17652178_ChIP-ChIP_JURKAT_Human1.77824403
25* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.76627401
26* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.76055372
27ELF1_17652178_ChIP-ChIP_JURKAT_Human1.75772183
28VDR_23849224_ChIP-Seq_CD4+_Human1.73360783
29* TTF2_22483619_ChIP-Seq_HELA_Human1.73200714
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.69415663
31SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.67463737
32* VDR_21846776_ChIP-Seq_THP-1_Human1.66556377
33* FOXP3_21729870_ChIP-Seq_TREG_Human1.64365326
34MYCN_18555785_ChIP-Seq_MESCs_Mouse1.62274045
35* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.58734537
36KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.58525472
37KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.58525472
38KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.58525472
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.57441551
40TP63_19390658_ChIP-ChIP_HaCaT_Human1.57130981
41* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.54453507
42* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.53468298
43JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.51131274
44DCP1A_22483619_ChIP-Seq_HELA_Human1.50118399
45KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.47733607
46ELK1_19687146_ChIP-ChIP_HELA_Human1.47459412
47GABP_19822575_ChIP-Seq_HepG2_Human1.44755963
48CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.44550002
49PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40450858
50KDM5A_27292631_Chip-Seq_BREAST_Human1.38058432
51* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37883270
52NANOG_18555785_ChIP-Seq_MESCs_Mouse1.36070118
53SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.33765386
54RBPJ_22232070_ChIP-Seq_NCS_Mouse1.32588526
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31208306
56SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.31062721
57POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.29294081
58SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.28462338
59SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.28104174
60SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.27104787
61THAP11_20581084_ChIP-Seq_MESCs_Mouse1.24626129
62STAT3_1855785_ChIP-Seq_MESCs_Mouse1.21353170
63TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20519539
64* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19703087
65KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.18772667
66SOX2_18555785_ChIP-Seq_MESCs_Mouse1.18636050
67PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.18283398
68ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17648572
69TP63_17297297_ChIP-ChIP_HaCaT_Human1.17592368
70* TFEB_21752829_ChIP-Seq_HELA_Human1.17173865
71* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.16991154
72ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.15959800
73* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.14528108
74MAF_26560356_Chip-Seq_TH1_Human1.14141099
75* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.13564328
76* UTX_26944678_Chip-Seq_JUKART_Human1.13353043
77* TCF7_22412390_ChIP-Seq_EML_Mouse1.13131828
78* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09595659
79E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06894003
80NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.06579265
81MYB_26560356_Chip-Seq_TH2_Human1.06116995
82FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05299426
83YY1_21170310_ChIP-Seq_MESCs_Mouse1.04835439
84FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.01759948
85SPI1_23547873_ChIP-Seq_NB4_Human1.00121335
86* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.99594541
87SCL_19346495_ChIP-Seq_HPC-7_Human0.97771474
88* SALL1_21062744_ChIP-ChIP_HESCs_Human0.97214257
89GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96698143
90POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.96397180
91MYB_26560356_Chip-Seq_TH1_Human0.96380591
92TCF3_18692474_ChIP-Seq_MEFs_Mouse0.95360151
93NANOG_21062744_ChIP-ChIP_HESCs_Human0.95185016
94CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94619547
95* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.94244043
96* ELK3_25401928_ChIP-Seq_HUVEC_Human0.94062911
97* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.93633287
98ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93052187
99* SOX17_20123909_ChIP-Seq_XEN_Mouse0.92753664
100* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92662550
101CLOCK_20551151_ChIP-Seq_293T_Human0.92300296
102BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.91729723
103IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.91373644
104MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.91161251
105* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.90347268
106SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.90059339
107* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.90035981
108HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.89421092
109TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89340488
110NOTCH1_21737748_ChIP-Seq_TLL_Human0.87684265
111HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.87359660
112CHD1_26751641_Chip-Seq_LNCaP_Human0.87226297
113* MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.86896119
114* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.86436224
115ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.85043212
116KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.85027620
117NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.83806388
118HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.83557082

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.55634568
2MP0003693_abnormal_embryo_hatching3.47821582
3MP0004957_abnormal_blastocyst_morpholog3.33759756
4MP0003111_abnormal_nucleus_morphology3.29461613
5MP0003077_abnormal_cell_cycle3.20278892
6MP0010352_gastrointestinal_tract_polyps2.96236904
7MP0008057_abnormal_DNA_replication2.82267929
8MP0002396_abnormal_hematopoietic_system2.70799405
9MP0009379_abnormal_foot_pigmentation2.67663032
10MP0008007_abnormal_cellular_replicative2.63856231
11MP0003123_paternal_imprinting2.31343525
12MP0002009_preneoplasia2.23249592
13MP0008058_abnormal_DNA_repair2.23163351
14MP0004808_abnormal_hematopoietic_stem2.17411354
15MP0001730_embryonic_growth_arrest2.16362483
16MP0000537_abnormal_urethra_morphology2.10348008
17MP0000350_abnormal_cell_proliferation2.06075944
18MP0010307_abnormal_tumor_latency1.90281418
19MP0008932_abnormal_embryonic_tissue1.82601790
20MP0003763_abnormal_thymus_physiology1.80236773
21MP0005076_abnormal_cell_differentiation1.79390083
22MP0000566_synostosis1.74815167
23MP0006054_spinal_hemorrhage1.71843655
24MP0003705_abnormal_hypodermis_morpholog1.71079360
25MP0000490_abnormal_crypts_of1.70406228
26MP0004197_abnormal_fetal_growth/weight/1.69999374
27MP0010030_abnormal_orbit_morphology1.66906412
28MP0002084_abnormal_developmental_patter1.65071178
29MP0001697_abnormal_embryo_size1.62501553
30MP0009053_abnormal_anal_canal1.62044655
31MP0005380_embryogenesis_phenotype1.61812541
32MP0001672_abnormal_embryogenesis/_devel1.61812541
33MP0003121_genomic_imprinting1.56758057
34MP0002085_abnormal_embryonic_tissue1.55138267
35MP0009278_abnormal_bone_marrow1.51835837
36MP0003984_embryonic_growth_retardation1.50927459
37MP0002088_abnormal_embryonic_growth/wei1.49182291
38* MP0002080_prenatal_lethality1.49109673
39MP0002086_abnormal_extraembryonic_tissu1.48435739
40MP0000703_abnormal_thymus_morphology1.47864097
41MP0003567_abnormal_fetal_cardiomyocyte1.47178488
42MP0002398_abnormal_bone_marrow1.34564506
43MP0009333_abnormal_splenocyte_physiolog1.33348060
44MP0001346_abnormal_lacrimal_gland1.30819523
45* MP0002019_abnormal_tumor_incidence1.30261561
46MP0005397_hematopoietic_system_phenotyp1.30091517
47MP0001545_abnormal_hematopoietic_system1.30091517
48MP0010234_abnormal_vibrissa_follicle1.24061470
49MP0000313_abnormal_cell_death1.22400172
50MP0003941_abnormal_skin_development1.21332601
51MP0005023_abnormal_wound_healing1.20902255
52MP0003566_abnormal_cell_adhesion1.20160127
53MP0001849_ear_inflammation1.20096964
54MP0002722_abnormal_immune_system1.20050564
55MP0001293_anophthalmia1.19510629
56MP0003786_premature_aging1.18473934
57MP0000733_abnormal_muscle_development1.18265727
58MP0004185_abnormal_adipocyte_glucose1.14564718
59MP0003221_abnormal_cardiomyocyte_apopto1.11215051
60MP0003119_abnormal_digestive_system1.07621655
61MP0006292_abnormal_olfactory_placode1.07376438
62MP0000685_abnormal_immune_system1.06807686
63MP0000689_abnormal_spleen_morphology1.06757504
64MP0008877_abnormal_DNA_methylation1.04746454
65MP0000858_altered_metastatic_potential1.04534253
66MP0001915_intracranial_hemorrhage1.03028348
67MP0000428_abnormal_craniofacial_morphol1.00807202
68MP0002796_impaired_skin_barrier0.98803188
69MP0005501_abnormal_skin_physiology0.98403834
70MP0009697_abnormal_copulation0.98191855
71MP0002429_abnormal_blood_cell0.97356178
72MP0003890_abnormal_embryonic-extraembry0.96706506
73MP0002166_altered_tumor_susceptibility0.95860039
74MP0002111_abnormal_tail_morphology0.95114098
75MP0003115_abnormal_respiratory_system0.94520836
76MP0000716_abnormal_immune_system0.91627171
77MP0000465_gastrointestinal_hemorrhage0.91034984
78MP0004264_abnormal_extraembryonic_tissu0.90955295
79MP0001800_abnormal_humoral_immune0.89919323
80MP0003937_abnormal_limbs/digits/tail_de0.88989451
81MP0002092_abnormal_eye_morphology0.88909017
82MP0002877_abnormal_melanocyte_morpholog0.88389749
83MP0000477_abnormal_intestine_morphology0.87663118
84MP0003315_abnormal_perineum_morphology0.87244015
85MP0003300_gastrointestinal_ulcer0.84635677
86MP0003942_abnormal_urinary_system0.83541017
87MP0002932_abnormal_joint_morphology0.81777072
88MP0002925_abnormal_cardiovascular_devel0.81767331
89MP0000432_abnormal_head_morphology0.81764912
90MP0003861_abnormal_nervous_system0.80069569
91MP0002420_abnormal_adaptive_immunity0.80045893
92MP0002006_tumorigenesis0.79288293
93MP0002282_abnormal_trachea_morphology0.78964148
94MP0003755_abnormal_palate_morphology0.78939962
95MP0001348_abnormal_lacrimal_gland0.78825359
96MP0002938_white_spotting0.78000222
97MP0001819_abnormal_immune_cell0.77932176
98MP0010155_abnormal_intestine_physiology0.77895934
99MP0002233_abnormal_nose_morphology0.77566151
100MP0002405_respiratory_system_inflammati0.77349535
101MP0005623_abnormal_meninges_morphology0.76820374
102MP0009672_abnormal_birth_weight0.76538581
103MP0001340_abnormal_eyelid_morphology0.75900455
104MP0002452_abnormal_antigen_presenting0.75299190
105MP0000762_abnormal_tongue_morphology0.74872099
106MP0008995_early_reproductive_senescence0.74841281
107MP0001873_stomach_inflammation0.73706059
108MP0002653_abnormal_ependyma_morphology0.73097681
109MP0003943_abnormal_hepatobiliary_system0.72931124
110MP0003283_abnormal_digestive_organ0.72695244
111MP0002697_abnormal_eye_size0.72060282
112MP0003935_abnormal_craniofacial_develop0.71924933
113MP0005621_abnormal_cell_physiology0.70865869
114MP0005248_abnormal_Harderian_gland0.70044119
115MP0002089_abnormal_postnatal_growth/wei0.69584618
116MP0005384_cellular_phenotype0.69063066
117MP0009703_decreased_birth_body0.68715793
118MP0001286_abnormal_eye_development0.68623298
119MP0003385_abnormal_body_wall0.68463903
120MP0001835_abnormal_antigen_presentation0.68339064
121MP0005075_abnormal_melanosome_morpholog0.68116175
122MP0003448_altered_tumor_morphology0.67702453
123MP0000358_abnormal_cell_content/0.66872949
124MP0000377_abnormal_hair_follicle0.66484166
125MP0002081_perinatal_lethality0.63314919
126MP0003091_abnormal_cell_migration0.62802710

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)3.97078520
2Colon cancer (HP:0003003)3.83282640
3Abnormality of cells of the erythroid lineage (HP:0012130)3.67164174
4Chromosomal breakage induced by crosslinking agents (HP:0003221)3.30907215
5Selective tooth agenesis (HP:0001592)3.28977811
6Abnormal number of erythroid precursors (HP:0012131)3.23182846
7Ependymoma (HP:0002888)3.21531063
8Thrombocytosis (HP:0001894)3.01938096
9Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.96553714
10Short 4th metacarpal (HP:0010044)2.96553714
11Medulloblastoma (HP:0002885)2.93414596
12Deviation of the thumb (HP:0009603)2.82371266
13Proximal placement of thumb (HP:0009623)2.78575070
14Increased nuchal translucency (HP:0010880)2.67119640
15Basal cell carcinoma (HP:0002671)2.66780670
1611 pairs of ribs (HP:0000878)2.62959946
17Cortical dysplasia (HP:0002539)2.62672512
18High anterior hairline (HP:0009890)2.59611877
19Hyperacusis (HP:0010780)2.47186763
20Missing ribs (HP:0000921)2.44210657
21Abnormality of the anterior horn cell (HP:0006802)2.43824391
22Degeneration of anterior horn cells (HP:0002398)2.43824391
23Nephroblastoma (Wilms tumor) (HP:0002667)2.42568384
24Abnormal number of incisors (HP:0011064)2.40653465
25Increased density of long bones (HP:0006392)2.38926728
26Abnormality of the astrocytes (HP:0100707)2.33620654
27Astrocytoma (HP:0009592)2.33620654
28Renal duplication (HP:0000075)2.33217415
29Spastic diplegia (HP:0001264)2.28644470
30Microvesicular hepatic steatosis (HP:0001414)2.28117578
31Abnormality of the calcaneus (HP:0008364)2.27279665
32Cutaneous melanoma (HP:0012056)2.26612845
33Birth length less than 3rd percentile (HP:0003561)2.25668468
34Amaurosis fugax (HP:0100576)2.24829472
35Pallor (HP:0000980)2.24472873
36Embryonal renal neoplasm (HP:0011794)2.23995427
37Agnosia (HP:0010524)2.23457810
38Neoplasm of the pancreas (HP:0002894)2.20076826
39Broad distal phalanx of finger (HP:0009836)2.19008749
40Volvulus (HP:0002580)2.16598836
41Aplastic anemia (HP:0001915)2.15663248
42Myelodysplasia (HP:0002863)2.14098988
43Abnormality of the preputium (HP:0100587)2.12677457
44Abnormality of the 4th metacarpal (HP:0010012)2.12610281
45Macrocytic anemia (HP:0001972)2.12298633
46Deep philtrum (HP:0002002)2.11938657
47Abnormality of the parietal bone (HP:0002696)2.11104819
48Atresia of the external auditory canal (HP:0000413)2.10451546
49Asymmetry of the thorax (HP:0001555)2.10386382
50Triphalangeal thumb (HP:0001199)2.10181202
51Duplication of thumb phalanx (HP:0009942)2.10179853
52Abnormality of reticulocytes (HP:0004312)2.08106372
53Patellar aplasia (HP:0006443)2.05441342
54IgM deficiency (HP:0002850)1.99910731
55High pitched voice (HP:0001620)1.98408777
56Ankyloglossia (HP:0010296)1.97934425
57Oral leukoplakia (HP:0002745)1.97146653
58Rhabdomyosarcoma (HP:0002859)1.97132322
59Abnormality of the distal phalanx of the thumb (HP:0009617)1.95282570
60Broad palm (HP:0001169)1.94368411
61Aplasia/Hypoplasia of the patella (HP:0006498)1.94365546
62Acute myeloid leukemia (HP:0004808)1.93731903
63Glioma (HP:0009733)1.93137920
64Neoplasm of the oral cavity (HP:0100649)1.92136528
65Partial duplication of thumb phalanx (HP:0009944)1.92058867
66Skin tags (HP:0010609)1.90069592
67Biliary tract neoplasm (HP:0100574)1.89252648
68Progressive external ophthalmoplegia (HP:0000590)1.88936696
69Absent thumb (HP:0009777)1.87693610
70Gastrointestinal carcinoma (HP:0002672)1.87361502
71Malignant gastrointestinal tract tumors (HP:0006749)1.87361502
72Bicuspid aortic valve (HP:0001647)1.87134728
73Viral hepatitis (HP:0006562)1.86745982
74Abnormality of the fingertips (HP:0001211)1.84282036
75Long palpebral fissure (HP:0000637)1.83941227
76Preauricular skin tag (HP:0000384)1.83817404
77Panhypogammaglobulinemia (HP:0003139)1.83591274
78Multiple enchondromatosis (HP:0005701)1.83469368
79Leiomyosarcoma (HP:0100243)1.83352780
80Uterine leiomyosarcoma (HP:0002891)1.83352780
81Protrusio acetabuli (HP:0003179)1.83243924
82Chromsome breakage (HP:0040012)1.81738287
83Partial duplication of the phalanx of hand (HP:0009999)1.81250241
84Horseshoe kidney (HP:0000085)1.81187981
85Aplasia/Hypoplasia of the sacrum (HP:0008517)1.80069531
86Bowel diverticulosis (HP:0005222)1.79573543
87Glossoptosis (HP:0000162)1.79475699
88Abnormality of chromosome stability (HP:0003220)1.78408456
89Depressed nasal ridge (HP:0000457)1.78083676
90Thick lower lip vermilion (HP:0000179)1.78009044
91Squamous cell carcinoma (HP:0002860)1.77943524
92Spinal cord lesions (HP:0100561)1.77179674
93Syringomyelia (HP:0003396)1.77179674
94Deep palmar crease (HP:0006191)1.75627176
95Ectopic kidney (HP:0000086)1.75489420
96Optic nerve coloboma (HP:0000588)1.74669285
97Esophageal atresia (HP:0002032)1.73907926
98Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.73300028
99Aplasia/Hypoplasia of the spleen (HP:0010451)1.73232412
100Trigonocephaly (HP:0000243)1.72825964
101Abnormal lung lobation (HP:0002101)1.72764819
102Acute lymphatic leukemia (HP:0006721)1.72636892
103Lymphoma (HP:0002665)1.72457476
104Asplenia (HP:0001746)1.71837274
105Neoplasm of the colon (HP:0100273)1.71467885
106Ankle contracture (HP:0006466)1.71141352
107Overlapping toe (HP:0001845)1.70920999
108Long eyelashes (HP:0000527)1.67857862
109Trismus (HP:0000211)1.67701244
110Delayed cranial suture closure (HP:0000270)1.67354501
111Aplasia/Hypoplasia of the uvula (HP:0010293)1.66111606
112Neoplasm of striated muscle (HP:0009728)1.65668173
113Cutis marmorata (HP:0000965)1.65571782
114Subacute progressive viral hepatitis (HP:0006572)1.64185238
115Meckel diverticulum (HP:0002245)1.64160457
116Rectal prolapse (HP:0002035)1.63970749
117Short middle phalanx of the 5th finger (HP:0004220)1.63651452
118Choanal atresia (HP:0000453)1.63211672
119Prominent nose (HP:0000448)1.63109649
120Small intestinal stenosis (HP:0012848)1.62672519
121Duodenal stenosis (HP:0100867)1.62672519
122Ovarian neoplasm (HP:0100615)1.62404047
123Generalized hypotonia (HP:0001290)1.62319163
124Abnormality of the septum pellucidum (HP:0007375)1.62316713
125Microglossia (HP:0000171)1.61713511
126Skull defect (HP:0001362)1.61434651
127Broad thumb (HP:0011304)1.60473140
128T lymphocytopenia (HP:0005403)1.59709856
129Intestinal polyp (HP:0005266)1.59508527
130Disproportionate tall stature (HP:0001519)1.59200210
131Renovascular hypertension (HP:0100817)1.58566303
132Overriding aorta (HP:0002623)1.58312821
133Tracheoesophageal fistula (HP:0002575)1.58151772
134Persistence of primary teeth (HP:0006335)1.57507233
135Freckling (HP:0001480)1.57370597
136Abnormality of the labia minora (HP:0012880)1.57278394
137Abnormality of T cells (HP:0002843)1.56853453
138Vertebral hypoplasia (HP:0008417)1.56250780
139Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.56250780
140Abnormality of the ileum (HP:0001549)1.55993650
141Abnormality of oral frenula (HP:0000190)1.55468024
142Cafe-au-lait spot (HP:0000957)1.55299908
143Short 5th finger (HP:0009237)1.54775030
144Arnold-Chiari malformation (HP:0002308)1.54359589
145Stenosis of the external auditory canal (HP:0000402)1.54287352
146Recurrent viral infections (HP:0004429)1.53872132
147Shallow orbits (HP:0000586)1.53766714
148Recurrent bronchitis (HP:0002837)1.53675233
149Transitional cell carcinoma of the bladder (HP:0006740)1.53443858
150Hypotelorism (HP:0000601)1.52382575
151Abnormality of the duodenum (HP:0002246)1.51978452
152Capillary hemangiomas (HP:0005306)1.50983405
153Absent radius (HP:0003974)1.50726735
154Uterine neoplasm (HP:0010784)1.50636853
155Flared metaphyses (HP:0003015)1.49930138
156Coarctation of aorta (HP:0001680)1.49695740

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K4.79616406
2CDC73.66777505
3SMG13.25039128
4PKN22.95251508
5TSSK62.85855791
6WEE12.78115372
7BUB12.66572469
8MAP3K102.62450017
9RPS6KB22.60077915
10NEK22.44362534
11VRK22.29306742
12TAF12.18358399
13PRPF4B2.18039676
14CDK122.07470748
15TRIB31.92919391
16MAP4K11.91331825
17MKNK11.90412895
18LRRK21.86549423
19STK101.82384815
20PBK1.76397375
21SRPK11.67556563
22PAK41.60098692
23RPS6KA41.59160252
24ATR1.56608470
25FLT31.56096241
26SCYL21.52162325
27NEK11.52028943
28TTK1.50679315
29NME21.49681111
30MAP3K81.48889995
31CDK71.47064247
32TESK21.45099675
33CDK41.42056171
34CDK191.39453358
35AURKB1.36728558
36ALK1.29342134
37PLK11.26419854
38DYRK31.26058449
39EIF2AK11.22312469
40ACVR1B1.21799648
41PNCK1.18138010
42SIK31.16925314
43MAP2K31.16160612
44PLK31.15769407
45CHEK11.15344002
46BRD41.15059677
47ICK1.13936010
48EPHA21.13747838
49TTN1.11191936
50BRSK21.09501010
51JAK31.09201240
52BTK1.08212163
53CDK61.07924608
54PTK61.02231137
55ZAP700.99776136
56PIM10.99576694
57YES10.95099176
58PAK20.93118144
59FGFR20.88837482
60GRK60.86430860
61STK40.84400550
62MKNK20.82099916
63FGFR10.82030579
64EIF2AK20.81666553
65TESK10.81465239
66CHEK20.80832797
67LATS20.80201967
68CDK20.78590399
69MTOR0.77268493
70ILK0.77143619
71ATM0.76463317
72CLK10.76389077
73MAP3K140.73304492
74KSR10.71187464
75MELK0.69983054
76PDGFRA0.68789437
77PLK40.68135907
78ITK0.66762225
79STK240.66740984
80SIK10.66500076
81AURKA0.65439786
82VRK10.62838343
83BRSK10.62089960
84IRAK40.61965030
85MAPKAPK30.61806489
86STK30.61129011
87FGFR40.58698989
88EIF2AK30.58404864
89CSNK2A20.56947440
90CSF1R0.56757775
91STK160.55422594
92TLK10.53885720
93EPHB20.53509066
94CDK10.53099842
95CHUK0.52824991
96NLK0.52608696
97PAK10.52007926
98KIT0.50730324
99ERBB40.49428828
100MAP3K130.48550514
101TRIM280.47520696
102KSR20.46434410
103CDK80.45380451
104LATS10.45084645
105IRAK20.43538667
106FGFR30.43535647
107TXK0.43162169
108LCK0.41783946
109TYRO30.40844386
110PIM20.40726182
111BRAF0.40634875
112CCNB10.40575684
113CDK90.38777598
114TEC0.38276606
115MST40.37188456
116AKT20.37086712
117TYK20.36946968
118CSNK2A10.36340919
119NEK90.35725050
120KDR0.35675156
121RPS6KA10.35656390
122PRKDC0.35566565
123RPS6KL10.35081246
124RPS6KC10.35081246
125RPS6KA60.34754861
126MAPKAPK20.33630965
127CSNK1D0.33303845
128MAP3K30.32985280
129CDK30.32701304
130RPS6KA50.32082170
131RPS6KB10.29887221
132IRAK30.28430124

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.31925740
2Mismatch repair_Homo sapiens_hsa034303.65693878
3Ribosome_Homo sapiens_hsa030103.42061023
4Spliceosome_Homo sapiens_hsa030403.16114981
5* RNA transport_Homo sapiens_hsa030132.75377901
6Base excision repair_Homo sapiens_hsa034102.71903694
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.69612068
8Cell cycle_Homo sapiens_hsa041102.56594127
9One carbon pool by folate_Homo sapiens_hsa006702.48046784
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.43178054
11Nucleotide excision repair_Homo sapiens_hsa034202.39468749
12Homologous recombination_Homo sapiens_hsa034402.10398552
13mRNA surveillance pathway_Homo sapiens_hsa030151.92269936
14Non-homologous end-joining_Homo sapiens_hsa034501.88576290
15RNA polymerase_Homo sapiens_hsa030201.75315023
16RNA degradation_Homo sapiens_hsa030181.64585761
17Proteasome_Homo sapiens_hsa030501.64111461
18p53 signaling pathway_Homo sapiens_hsa041151.59327373
19Pyrimidine metabolism_Homo sapiens_hsa002401.54861538
20Antigen processing and presentation_Homo sapiens_hsa046121.46727539
21Fanconi anemia pathway_Homo sapiens_hsa034601.46293445
22Viral carcinogenesis_Homo sapiens_hsa052031.37599439
23Primary immunodeficiency_Homo sapiens_hsa053401.31582955
24Chronic myeloid leukemia_Homo sapiens_hsa052201.28759533
25HTLV-I infection_Homo sapiens_hsa051661.27821311
26Epstein-Barr virus infection_Homo sapiens_hsa051691.25889246
27Herpes simplex infection_Homo sapiens_hsa051681.20570056
28Small cell lung cancer_Homo sapiens_hsa052221.18918206
29Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.18705349
30MicroRNAs in cancer_Homo sapiens_hsa052061.18482030
31Basal transcription factors_Homo sapiens_hsa030221.11253569
32Colorectal cancer_Homo sapiens_hsa052101.07825687
33Thyroid cancer_Homo sapiens_hsa052161.05408121
34Systemic lupus erythematosus_Homo sapiens_hsa053221.04215912
35Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.03279646
36Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.01334934
37Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.00399754
38Basal cell carcinoma_Homo sapiens_hsa052170.99506549
39Transcriptional misregulation in cancer_Homo sapiens_hsa052020.97325614
40Notch signaling pathway_Homo sapiens_hsa043300.95958351
41Renal cell carcinoma_Homo sapiens_hsa052110.94724138
42Viral myocarditis_Homo sapiens_hsa054160.92590219
43Measles_Homo sapiens_hsa051620.91527806
44Hippo signaling pathway_Homo sapiens_hsa043900.89330863
45Shigellosis_Homo sapiens_hsa051310.86076447
46Carbon metabolism_Homo sapiens_hsa012000.85684582
47Cysteine and methionine metabolism_Homo sapiens_hsa002700.84404236
48Hepatitis B_Homo sapiens_hsa051610.84387091
49Apoptosis_Homo sapiens_hsa042100.83193477
50Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.81425590
51Oocyte meiosis_Homo sapiens_hsa041140.80595600
52Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.80357115
53Non-small cell lung cancer_Homo sapiens_hsa052230.79660600
54Central carbon metabolism in cancer_Homo sapiens_hsa052300.79369388
55Acute myeloid leukemia_Homo sapiens_hsa052210.79342324
56T cell receptor signaling pathway_Homo sapiens_hsa046600.79275784
57NF-kappa B signaling pathway_Homo sapiens_hsa040640.78859637
58Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.77553759
59Adherens junction_Homo sapiens_hsa045200.76347972
60B cell receptor signaling pathway_Homo sapiens_hsa046620.74640044
61Proteoglycans in cancer_Homo sapiens_hsa052050.74409182
62TGF-beta signaling pathway_Homo sapiens_hsa043500.74367345
63Protein export_Homo sapiens_hsa030600.72958122
64Pancreatic cancer_Homo sapiens_hsa052120.72403833
65Bladder cancer_Homo sapiens_hsa052190.70682537
66Leukocyte transendothelial migration_Homo sapiens_hsa046700.69870599
67Cyanoamino acid metabolism_Homo sapiens_hsa004600.69324797
68Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.67292204
69Purine metabolism_Homo sapiens_hsa002300.66137838
70* Legionellosis_Homo sapiens_hsa051340.65433183
71Pathways in cancer_Homo sapiens_hsa052000.65187293
72Endometrial cancer_Homo sapiens_hsa052130.63519701
73mTOR signaling pathway_Homo sapiens_hsa041500.61905808
74AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.61251546
75HIF-1 signaling pathway_Homo sapiens_hsa040660.61065374
76Selenocompound metabolism_Homo sapiens_hsa004500.60954245
77Toxoplasmosis_Homo sapiens_hsa051450.59764730
78Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59544936
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59234573
80Hedgehog signaling pathway_Homo sapiens_hsa043400.58845690
81Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.58588514
82Leishmaniasis_Homo sapiens_hsa051400.58433093
83N-Glycan biosynthesis_Homo sapiens_hsa005100.56644221
84Biosynthesis of amino acids_Homo sapiens_hsa012300.56367611
85Prostate cancer_Homo sapiens_hsa052150.55948038
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55598361
87ErbB signaling pathway_Homo sapiens_hsa040120.55553210
88Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55489137
89Influenza A_Homo sapiens_hsa051640.54604611
90Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.54002020
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.53928953
92Hematopoietic cell lineage_Homo sapiens_hsa046400.53872370
93Jak-STAT signaling pathway_Homo sapiens_hsa046300.53087176
94Focal adhesion_Homo sapiens_hsa045100.49999833
95NOD-like receptor signaling pathway_Homo sapiens_hsa046210.47778934
96Alcoholism_Homo sapiens_hsa050340.46886556
97Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.46481773
98Platelet activation_Homo sapiens_hsa046110.46375887
99Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.43531944
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43163263
101Pentose phosphate pathway_Homo sapiens_hsa000300.42304159
102Prolactin signaling pathway_Homo sapiens_hsa049170.40717346
103Inositol phosphate metabolism_Homo sapiens_hsa005620.40532671
104Wnt signaling pathway_Homo sapiens_hsa043100.40043452
105PI3K-Akt signaling pathway_Homo sapiens_hsa041510.39974294
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38798454
107Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.38615220
108Osteoclast differentiation_Homo sapiens_hsa043800.37356239
109Glioma_Homo sapiens_hsa052140.36886945
110VEGF signaling pathway_Homo sapiens_hsa043700.36535326
111TNF signaling pathway_Homo sapiens_hsa046680.36462881
112Intestinal immune network for IgA production_Homo sapiens_hsa046720.36085361
113Choline metabolism in cancer_Homo sapiens_hsa052310.34555077
114Melanoma_Homo sapiens_hsa052180.33032938
115FoxO signaling pathway_Homo sapiens_hsa040680.33027948
116Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.32880545
117Lysine degradation_Homo sapiens_hsa003100.32232867
118Pyruvate metabolism_Homo sapiens_hsa006200.30749281

Most similar genes based on co-expression Upload to Enrichr

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