ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.08010501
2	ribosomal small subunit assembly (GO:0000028)	4.93245805
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.61606739
4	ATP synthesis coupled proton transport (GO:0015986)	4.61606739
5	positive regulation of prostaglandin secretion (GO:0032308)	4.29189689
6	viral transcription (GO:0019083)	4.12999782
7	behavioral response to nicotine (GO:0035095)	4.09278710
8	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.03513707
9	translational termination (GO:0006415)	3.95547067
10	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.81761333
11	ribosomal large subunit biogenesis (GO:0042273)	3.79490204
12	translational elongation (GO:0006414)	3.73481689
13	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.72904807
14	cotranslational protein targeting to membrane (GO:0006613)	3.65429713
15	protein targeting to ER (GO:0045047)	3.61215128
16	regulation of prostaglandin secretion (GO:0032306)	3.59054660
17	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	3.51786079
18	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.44683548
19	regulation of isotype switching to IgG isotypes (GO:0048302)	3.43798680
20	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.41976787
21	positive regulation of interleukin-17 production (GO:0032740)	3.41309934
22	rRNA modification (GO:0000154)	3.41045448
23	protein localization to endoplasmic reticulum (GO:0070972)	3.40788598
24	maturation of SSU-rRNA (GO:0030490)	3.36249304
25	positive regulation of defense response to virus by host (GO:0002230)	3.27426520
26	GTP biosynthetic process (GO:0006183)	3.25609276
27	water-soluble vitamin biosynthetic process (GO:0042364)	3.24545968
28	pseudouridine synthesis (GO:0001522)	3.21156594
29	positive regulation of fatty acid transport (GO:2000193)	3.21147808
30	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.20219378
31	piRNA metabolic process (GO:0034587)	3.20009998
32	response to pheromone (GO:0019236)	3.17738306
33	L-fucose catabolic process (GO:0042355)	3.16907610
34	fucose catabolic process (GO:0019317)	3.16907610
35	L-fucose metabolic process (GO:0042354)	3.16907610
36	chaperone-mediated protein transport (GO:0072321)	3.13498990
37	protein neddylation (GO:0045116)	3.11574201
38	translational initiation (GO:0006413)	3.07223767
39	base-excision repair, AP site formation (GO:0006285)	3.06456279
40	positive regulation of icosanoid secretion (GO:0032305)	3.05729021
41	translation (GO:0006412)	3.01865645
42	viral life cycle (GO:0019058)	2.99707348
43	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.98989248
44	regulation of regulatory T cell differentiation (GO:0045589)	2.96208408
45	regulation of chronic inflammatory response (GO:0002676)	2.95238472
46	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.93918672
47	positive regulation of T-helper 1 type immune response (GO:0002827)	2.93299081
48	ribosomal small subunit biogenesis (GO:0042274)	2.91793296
49	regulation of immunoglobulin secretion (GO:0051023)	2.89924125
50	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.89671554
51	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.89478998
52	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.87100111
53	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.86059468
54	NADH dehydrogenase complex assembly (GO:0010257)	2.86059468
55	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.86059468
56	positive regulation of activated T cell proliferation (GO:0042104)	2.83945229
57	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.82686645
58	ribonucleoprotein complex biogenesis (GO:0022613)	2.80954956
59	cellular protein complex disassembly (GO:0043624)	2.78582696
60	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.76035179
61	protein complex biogenesis (GO:0070271)	2.75904322
62	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.74391661
63	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.73036160
64	rRNA metabolic process (GO:0016072)	2.71724017
65	rRNA processing (GO:0006364)	2.70643940
66	respiratory chain complex IV assembly (GO:0008535)	2.68990798
67	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.68232505
68	cellular component biogenesis (GO:0044085)	2.67932385
69	UTP biosynthetic process (GO:0006228)	2.67658071
70	negative regulation of mast cell activation (GO:0033004)	2.66671618
71	rRNA methylation (GO:0031167)	2.65994539
72	regulation of memory T cell differentiation (GO:0043380)	2.64987544
73	cellular response to interleukin-15 (GO:0071350)	2.64144908
74	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.63851508
75	sleep (GO:0030431)	2.62046848
76	electron transport chain (GO:0022900)	2.62038121
77	UTP metabolic process (GO:0046051)	2.61343923
78	mannosylation (GO:0097502)	2.59229219
79	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	2.57979077
80	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.56449185
81	mast cell activation (GO:0045576)	2.55420564
82	peptidyl-histidine modification (GO:0018202)	2.54815298
83	respiratory electron transport chain (GO:0022904)	2.54419796
84	preassembly of GPI anchor in ER membrane (GO:0016254)	2.54202714
85	production of molecular mediator of immune response (GO:0002440)	2.52501303
86	rRNA catabolic process (GO:0016075)	2.51296188
87	mitochondrial respiratory chain complex assembly (GO:0033108)	2.50539744
88	cellular response to exogenous dsRNA (GO:0071360)	2.50219906
89	ATP biosynthetic process (GO:0006754)	2.50113524
90	positive regulation of DNA recombination (GO:0045911)	2.49604867
91	tRNA processing (GO:0008033)	2.47439030
92	immunoglobulin mediated immune response (GO:0016064)	2.44671229
93	ribosome biogenesis (GO:0042254)	2.44104120
94	regulation of T cell mediated cytotoxicity (GO:0001914)	2.43999207
95	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.42429742
96	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.42429742
97	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.42324548
98	mast cell activation involved in immune response (GO:0002279)	2.41579074
99	mast cell degranulation (GO:0043303)	2.41579074
100	adenosine metabolic process (GO:0046085)	2.39899179

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.80170604
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.26770723
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.96443384
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.35065747
5	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.27536967
6	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.25928812
7	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.01775638
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.80225734
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.71058812
10	VDR_23849224_ChIP-Seq_CD4+_Human	2.68049373
11	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.67816520
12	ZNF274_21170338_ChIP-Seq_K562_Hela	2.66369228
13	VDR_22108803_ChIP-Seq_LS180_Human	2.62983455
14	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.61502297
15	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.47992071
16	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.45446705
17	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.31942973
18	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.30781712
19	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.30465086
20	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.28015901
21	FOXP3_21729870_ChIP-Seq_TREG_Human	2.27607090
22	ELK1_19687146_ChIP-ChIP_HELA_Human	2.22236998
23	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.09033216
24	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.01664859
25	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.00317963
26	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.91800798
27	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.91798452
28	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.86131654
29	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.82587327
30	TP53_22573176_ChIP-Seq_HFKS_Human	1.79951141
31	MYC_18940864_ChIP-ChIP_HL60_Human	1.79095872
32	GATA3_26560356_Chip-Seq_TH2_Human	1.74001468
33	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.60739431
34	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.60707600
35	IGF1R_20145208_ChIP-Seq_DFB_Human	1.57358720
36	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.56224341
37	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.55047722
38	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.53984256
39	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.45081477
40	EWS_26573619_Chip-Seq_HEK293_Human	1.43170918
41	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.40320166
42	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.38674489
43	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.38585751
44	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.37181833
45	TTF2_22483619_ChIP-Seq_HELA_Human	1.34965101
46	MYB_26560356_Chip-Seq_TH2_Human	1.34808235
47	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.33400145
48	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.32412223
49	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.32412223
50	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.29825101
51	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.28481799
52	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.27228382
53	FUS_26573619_Chip-Seq_HEK293_Human	1.27076934
54	AR_20517297_ChIP-Seq_VCAP_Human	1.26815572
55	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.26201495
56	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.24185823
57	SOX2_19829295_ChIP-Seq_ESCs_Human	1.21699646
58	NANOG_19829295_ChIP-Seq_ESCs_Human	1.21699646
59	NCOR_22424771_ChIP-Seq_293T_Human	1.19851669
60	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.18069754
61	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.17781036
62	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.17017351
63	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.15932315
64	RUNX_20019798_ChIP-Seq_JUKART_Human	1.15847501
65	CIITA_25753668_ChIP-Seq_RAJI_Human	1.14757644
66	IRF1_19129219_ChIP-ChIP_H3396_Human	1.14633589
67	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.13138614
68	STAT1_20625510_ChIP-Seq_HELA_Human	1.10610390
69	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.10451959
70	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.07815342
71	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.05860378
72	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.04052922
73	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.03088974
74	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.02515232
75	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.01636408
76	GATA3_27048872_Chip-Seq_THYMUS_Human	1.00912227
77	SPI1_23547873_ChIP-Seq_NB4_Human	1.00594030
78	HOXB7_26014856_ChIP-Seq_BT474_Human	1.00482920
79	ER_23166858_ChIP-Seq_MCF-7_Human	1.00267646
80	NANOG_20526341_ChIP-Seq_ESCs_Human	0.99734303
81	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.97826113
82	GABP_19822575_ChIP-Seq_HepG2_Human	0.97816669
83	TAF2_19829295_ChIP-Seq_ESCs_Human	0.97104408
84	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.95771309
85	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.93533056
86	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.93263084
87	DCP1A_22483619_ChIP-Seq_HELA_Human	0.93212055
88	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.92225395
89	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.91890068
90	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.91204119
91	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.90831414
92	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.90685009
93	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.90205587
94	ERA_21632823_ChIP-Seq_H3396_Human	0.90052605
95	MYC_19829295_ChIP-Seq_ESCs_Human	0.89794519
96	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.89502753
97	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.88563013
98	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.87080323
99	ERG_20517297_ChIP-Seq_VCAP_Human	0.85173049
100	CBP_20019798_ChIP-Seq_JUKART_Human	0.85103933

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001835_abnormal_antigen_presentation	4.27871790
2	MP0005671_abnormal_response_to	3.49476190
3	MP0002102_abnormal_ear_morphology	3.47316553
4	MP0002138_abnormal_hepatobiliary_system	3.23154089
5	MP0000685_abnormal_immune_system	2.57705007
6	MP0001986_abnormal_taste_sensitivity	2.53917504
7	MP0002148_abnormal_hypersensitivity_rea	2.49719179
8	MP0008877_abnormal_DNA_methylation	2.40325374
9	MP0001800_abnormal_humoral_immune	2.39591625
10	MP0002876_abnormal_thyroid_physiology	2.19279166
11	MP0001873_stomach_inflammation	2.14955065
12	MP0005075_abnormal_melanosome_morpholog	2.10069966
13	MP0005000_abnormal_immune_tolerance	2.09444437
14	MP0005387_immune_system_phenotype	2.08876819
15	MP0001790_abnormal_immune_system	2.08876819
16	MP0001968_abnormal_touch/_nociception	2.06620089
17	MP0005646_abnormal_pituitary_gland	2.05576141
18	MP0008872_abnormal_physiological_respon	2.04684689
19	MP0009379_abnormal_foot_pigmentation	2.04425654
20	MP0002166_altered_tumor_susceptibility	2.04209013
21	MP0009333_abnormal_splenocyte_physiolog	2.01019265
22	MP0009785_altered_susceptibility_to	2.00243849
23	MP0002006_tumorigenesis	1.93170201
24	MP0002723_abnormal_immune_serum	1.87113932
25	MP0006072_abnormal_retinal_apoptosis	1.84096803
26	MP0005084_abnormal_gallbladder_morpholo	1.78749189
27	MP0006292_abnormal_olfactory_placode	1.70440767
28	MP0004147_increased_porphyrin_level	1.67042659
29	MP0002452_abnormal_antigen_presenting	1.65881090
30	MP0008875_abnormal_xenobiotic_pharmacok	1.61483384
31	MP0002420_abnormal_adaptive_immunity	1.57661495
32	MP0001819_abnormal_immune_cell	1.56651241
33	MP0000372_irregular_coat_pigmentation	1.56067708
34	MP0000465_gastrointestinal_hemorrhage	1.51190839
35	MP0003436_decreased_susceptibility_to	1.50764671
36	MP0004885_abnormal_endolymph	1.50172772
37	MP0005645_abnormal_hypothalamus_physiol	1.49228822
38	MP0003724_increased_susceptibility_to	1.48998020
39	MP0009764_decreased_sensitivity_to	1.45773939
40	MP0003763_abnormal_thymus_physiology	1.45564712
41	MP0008058_abnormal_DNA_repair	1.41677906
42	MP0002163_abnormal_gland_morphology	1.41630837
43	MP0001348_abnormal_lacrimal_gland	1.40824234
44	MP0003186_abnormal_redox_activity	1.35771623
45	MP0001845_abnormal_inflammatory_respons	1.33281983
46	MP0003786_premature_aging	1.30863410
47	MP0002405_respiratory_system_inflammati	1.29074336
48	MP0003646_muscle_fatigue	1.27203574
49	MP0005025_abnormal_response_to	1.23854694
50	MP0002837_dystrophic_cardiac_calcinosis	1.22548535
51	MP0003195_calcinosis	1.22436847
52	MP0010155_abnormal_intestine_physiology	1.20958971
53	MP0005551_abnormal_eye_electrophysiolog	1.20847494
54	MP0002398_abnormal_bone_marrow	1.19415602
55	MP0004142_abnormal_muscle_tone	1.18152475
56	MP0001905_abnormal_dopamine_level	1.17410847
57	MP0003866_abnormal_defecation	1.13287732
58	MP0000716_abnormal_immune_system	1.12504357
59	MP0005167_abnormal_blood-brain_barrier	1.11872601
60	MP0004145_abnormal_muscle_electrophysio	1.11424080
61	MP0000689_abnormal_spleen_morphology	1.11303130
62	MP0006082_CNS_inflammation	1.04030518
63	MP0003011_delayed_dark_adaptation	1.03470649
64	MP0005389_reproductive_system_phenotype	1.01512489
65	MP0008469_abnormal_protein_level	0.99960025
66	MP0002419_abnormal_innate_immunity	0.98661323
67	MP0003806_abnormal_nucleotide_metabolis	0.98507639
68	MP0004043_abnormal_pH_regulation	0.98122668
69	MP0001919_abnormal_reproductive_system	0.97299478
70	MP0003638_abnormal_response/metabolism_	0.97250723
71	MP0008775_abnormal_heart_ventricle	0.96704448
72	MP0004742_abnormal_vestibular_system	0.96510723
73	MP0002429_abnormal_blood_cell	0.95974654
74	MP0005253_abnormal_eye_physiology	0.89214262
75	MP0003252_abnormal_bile_duct	0.88695413
76	MP0002736_abnormal_nociception_after	0.88580690
77	MP0006036_abnormal_mitochondrial_physio	0.87055130
78	MP0002277_abnormal_respiratory_mucosa	0.85768416
79	MP0005379_endocrine/exocrine_gland_phen	0.84867885
80	MP0002722_abnormal_immune_system	0.84624417
81	MP0003718_maternal_effect	0.84497415
82	MP0000427_abnormal_hair_cycle	0.83602987
83	MP0002254_reproductive_system_inflammat	0.83542720
84	MP0001440_abnormal_grooming_behavior	0.83495416
85	MP0008995_early_reproductive_senescence	0.83362024
86	MP0000230_abnormal_systemic_arterial	0.81327100
87	MP0001501_abnormal_sleep_pattern	0.81043863
88	MP0001663_abnormal_digestive_system	0.79957196
89	MP0010386_abnormal_urinary_bladder	0.79525909
90	MP0005410_abnormal_fertilization	0.78761415
91	MP0005636_abnormal_mineral_homeostasis	0.78022243
92	MP0001765_abnormal_ion_homeostasis	0.75776743
93	MP0009643_abnormal_urine_homeostasis	0.75565209
94	MP0005332_abnormal_amino_acid	0.73005136
95	MP0003878_abnormal_ear_physiology	0.72298736
96	MP0005377_hearing/vestibular/ear_phenot	0.72298736
97	MP0003283_abnormal_digestive_organ	0.71164833
98	MP0005085_abnormal_gallbladder_physiolo	0.71016591
99	MP0006276_abnormal_autonomic_nervous	0.69856477
100	MP0000703_abnormal_thymus_morphology	0.65531110

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	3.80274528
2	IgG deficiency (HP:0004315)	3.76236449
3	3-Methylglutaconic aciduria (HP:0003535)	3.66443148
4	Stomatitis (HP:0010280)	3.63679415
5	Acute encephalopathy (HP:0006846)	3.45906846
6	Mitochondrial inheritance (HP:0001427)	3.45559222
7	Elevated erythrocyte sedimentation rate (HP:0003565)	3.39881980
8	Increased CSF lactate (HP:0002490)	3.33857003
9	Abnormal mitochondria in muscle tissue (HP:0008316)	3.30984713
10	Progressive macrocephaly (HP:0004481)	3.28752694
11	Abnormality of B cell number (HP:0010975)	3.19516286
12	Abolished electroretinogram (ERG) (HP:0000550)	3.18441641
13	Congenital stationary night blindness (HP:0007642)	3.12037090
14	Hepatocellular necrosis (HP:0001404)	3.10754716
15	B lymphocytopenia (HP:0010976)	3.03225950
16	Abnormality of the prostate (HP:0008775)	3.00602791
17	Abnormality of cells of the erythroid lineage (HP:0012130)	2.94870790
18	Panhypogammaglobulinemia (HP:0003139)	2.94276246
19	Hypoproteinemia (HP:0003075)	2.89038067
20	Increased hepatocellular lipid droplets (HP:0006565)	2.80329666
21	Hepatic necrosis (HP:0002605)	2.78253628
22	Increased serum lactate (HP:0002151)	2.76758318
23	Lipid accumulation in hepatocytes (HP:0006561)	2.76130520
24	Abnormal number of erythroid precursors (HP:0012131)	2.69189336
25	Severe combined immunodeficiency (HP:0004430)	2.68778969
26	Increased IgM level (HP:0003496)	2.67057859
27	Pancreatic cysts (HP:0001737)	2.64448038
28	Abnormality of the renal cortex (HP:0011035)	2.59812582
29	Optic disc pallor (HP:0000543)	2.58558751
30	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.58294559
31	Abnormality of midbrain morphology (HP:0002418)	2.50436173
32	Molar tooth sign on MRI (HP:0002419)	2.50436173
33	Abnormal rod and cone electroretinograms (HP:0008323)	2.50141659
34	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.46991521
35	Congenital, generalized hypertrichosis (HP:0004540)	2.46801635
36	Asplenia (HP:0001746)	2.46608318
37	Thyroiditis (HP:0100646)	2.43136504
38	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.42416626
39	Exertional dyspnea (HP:0002875)	2.42003923
40	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.40928040
41	Type II lissencephaly (HP:0007260)	2.39965877
42	Abnormality of T cells (HP:0002843)	2.39111404
43	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.37101719
44	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.35971676
45	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.35971676
46	Lactic acidosis (HP:0003128)	2.32597246
47	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.30223218
48	Abnormal protein N-linked glycosylation (HP:0012347)	2.30223218
49	Abnormal protein glycosylation (HP:0012346)	2.30223218
50	Abnormal glycosylation (HP:0012345)	2.30223218
51	Abnormality of T cell physiology (HP:0011840)	2.30209592
52	Abnormality of T cell number (HP:0011839)	2.29531452
53	Pancreatic fibrosis (HP:0100732)	2.25615003
54	Type 2 muscle fiber atrophy (HP:0003554)	2.25238854
55	Renal cortical cysts (HP:0000803)	2.24282647
56	Cerebral edema (HP:0002181)	2.24059723
57	Pulmonary infiltrates (HP:0002113)	2.23883643
58	Reticulocytopenia (HP:0001896)	2.23445930
59	Abnormal drinking behavior (HP:0030082)	2.19960795
60	Polydipsia (HP:0001959)	2.19960795
61	Nephronophthisis (HP:0000090)	2.15632997
62	Hypomagnesemia (HP:0002917)	2.15400102
63	Methylmalonic acidemia (HP:0002912)	2.14632022
64	Prostate neoplasm (HP:0100787)	2.12565529
65	Polyuria (HP:0000103)	2.12363309
66	Chronic diarrhea (HP:0002028)	2.11353638
67	T lymphocytopenia (HP:0005403)	2.10111696
68	Retrobulbar optic neuritis (HP:0100654)	2.10013596
69	Optic neuritis (HP:0100653)	2.10013596
70	Attenuation of retinal blood vessels (HP:0007843)	2.09519595
71	Myositis (HP:0100614)	2.09016439
72	Increased intramyocellular lipid droplets (HP:0012240)	2.07226259
73	Renal Fanconi syndrome (HP:0001994)	2.06971471
74	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.05450530
75	Absent/shortened dynein arms (HP:0200106)	2.05450530
76	Recurrent cutaneous fungal infections (HP:0011370)	2.05052821
77	Chronic mucocutaneous candidiasis (HP:0002728)	2.05052821
78	Absent thumb (HP:0009777)	2.04158090
79	Type I transferrin isoform profile (HP:0003642)	2.03171478
80	Hypoplasia of the uterus (HP:0000013)	2.02737029
81	Aplasia/hypoplasia of the uterus (HP:0008684)	2.02268521
82	Methylmalonic aciduria (HP:0012120)	2.01577469
83	Abnormality of the renal medulla (HP:0100957)	2.01204776
84	Gastrointestinal infarctions (HP:0005244)	1.99996334
85	Stomach cancer (HP:0012126)	1.98892971
86	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.97711997
87	Abnormality of alanine metabolism (HP:0010916)	1.97711997
88	Hyperalaninemia (HP:0003348)	1.97711997
89	Lethargy (HP:0001254)	1.97166859
90	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.96491472
91	Pendular nystagmus (HP:0012043)	1.95850031
92	Respiratory failure (HP:0002878)	1.95204572
93	Autoimmune hemolytic anemia (HP:0001890)	1.94081352
94	Combined immunodeficiency (HP:0005387)	1.93457566
95	True hermaphroditism (HP:0010459)	1.92699121
96	Hypoglycemic seizures (HP:0002173)	1.90549608
97	Abnormality of eosinophils (HP:0001879)	1.87205378
98	Colon cancer (HP:0003003)	1.86624061
99	Decreased central vision (HP:0007663)	1.85960519
100	Muscle fiber atrophy (HP:0100295)	1.85745263

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	4.78873037
2	TXK	3.43227046
3	MAP4K2	3.21661806
4	TLK1	3.20897903
5	NUAK1	2.68398540
6	ADRBK2	2.67807328
7	STK16	2.67326313
8	TIE1	2.47474106
9	ZAK	2.44882696
10	VRK2	2.39715027
11	GRK1	2.13402881
12	EIF2AK3	2.10109087
13	TEC	2.01724110
14	FRK	2.00065012
15	WNK4	1.98081954
16	MST4	1.95563728
17	BMPR2	1.91897333
18	KIT	1.88520809
19	MAP4K1	1.83449124
20	FES	1.74720894
21	TSSK6	1.58013454
22	IKBKB	1.56346666
23	STK39	1.50120360
24	CDK19	1.40781140
25	PINK1	1.40371089
26	OXSR1	1.38138323
27	BMPR1B	1.31507043
28	BCKDK	1.31224874
29	MAP3K14	1.31080080
30	ITK	1.30726752
31	EIF2AK1	1.27096850
32	MAP3K12	1.21965757
33	VRK1	1.19259428
34	PHKG2	1.06480031
35	PHKG1	1.06480031
36	TAF1	1.04986721
37	CDK8	1.04732623
38	MAP2K2	1.01494755
39	GRK6	0.97863455
40	DAPK1	0.97388028
41	SYK	0.93717560
42	MAPKAPK3	0.93025533
43	PASK	0.91555323
44	CSF1R	0.91286781
45	JAK3	0.91136016
46	FLT3	0.90906374
47	WNK3	0.85780657
48	MAP2K6	0.85712258
49	LYN	0.84723861
50	TGFBR1	0.81661420
51	IKBKE	0.80820360
52	EIF2AK2	0.79849733
53	TRIM28	0.78209779
54	NEK1	0.77437785
55	DAPK2	0.72668645
56	BTK	0.72561580
57	RPS6KA5	0.69889734
58	GRK5	0.68573059
59	PLK3	0.68072748
60	PBK	0.67693166
61	PDK2	0.67438812
62	LCK	0.66891843
63	INSRR	0.65832508
64	PRKCQ	0.64635264
65	ADRBK1	0.64249103
66	TBK1	0.63063719
67	TRPM7	0.61735500
68	DYRK2	0.61328880
69	ABL2	0.61300458
70	PIK3CG	0.61127626
71	DAPK3	0.53294435
72	MYLK	0.53005659
73	NME2	0.52037554
74	MAPKAPK5	0.49438856
75	IGF1R	0.48365888
76	ILK	0.46994469
77	MKNK1	0.46674272
78	ERBB3	0.46368607
79	KDR	0.45690037
80	CLK1	0.45597131
81	MATK	0.44958814
82	SRPK1	0.44803555
83	HCK	0.42541521
84	CAMKK2	0.40596591
85	BUB1	0.39150415
86	ATR	0.38962301
87	MAPK13	0.38172555
88	PRKCD	0.37349253
89	ABL1	0.36069143
90	CSNK1G3	0.34989141
91	PIK3CA	0.34934571
92	CSNK2A2	0.34665815
93	PRKCE	0.32778183
94	RPS6KA4	0.31943548
95	RPS6KA6	0.30684679
96	WNK1	0.29666543
97	IRAK4	0.28760246
98	TNK2	0.28678389
99	MUSK	0.28159647
100	CHUK	0.27011684

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	4.48207262
2	Allograft rejection_Homo sapiens_hsa05330	3.88462908
3	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.58565257
4	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.54744317
5	Ribosome_Homo sapiens_hsa03010	3.45121607
6	Graft-versus-host disease_Homo sapiens_hsa05332	3.24352371
7	Type I diabetes mellitus_Homo sapiens_hsa04940	3.05668228
8	Proteasome_Homo sapiens_hsa03050	2.84305477
9	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	2.47781090
10	Oxidative phosphorylation_Homo sapiens_hsa00190	2.43934618
11	Primary immunodeficiency_Homo sapiens_hsa05340	2.00156678
12	Parkinsons disease_Homo sapiens_hsa05012	1.98385923
13	Linoleic acid metabolism_Homo sapiens_hsa00591	1.88492662
14	Protein export_Homo sapiens_hsa03060	1.84988769
15	Antigen processing and presentation_Homo sapiens_hsa04612	1.83279542
16	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.83018415
17	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.63671120
18	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.62408595
19	Rheumatoid arthritis_Homo sapiens_hsa05323	1.60580835
20	RNA polymerase_Homo sapiens_hsa03020	1.55821738
21	One carbon pool by folate_Homo sapiens_hsa00670	1.45422286
22	Homologous recombination_Homo sapiens_hsa03440	1.42278490
23	RNA degradation_Homo sapiens_hsa03018	1.36048815
24	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.27890487
25	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.27446829
26	Nitrogen metabolism_Homo sapiens_hsa00910	1.27325578
27	Basal transcription factors_Homo sapiens_hsa03022	1.25339877
28	Phototransduction_Homo sapiens_hsa04744	1.23361764
29	Alzheimers disease_Homo sapiens_hsa05010	1.23011369
30	Viral myocarditis_Homo sapiens_hsa05416	1.18994181
31	Ether lipid metabolism_Homo sapiens_hsa00565	1.16594512
32	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.15595583
33	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.15231276
34	Non-homologous end-joining_Homo sapiens_hsa03450	1.11632100
35	Leishmaniasis_Homo sapiens_hsa05140	1.11303676
36	Huntingtons disease_Homo sapiens_hsa05016	1.09751563
37	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.04505391
38	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.03501887
39	Propanoate metabolism_Homo sapiens_hsa00640	1.03386811
40	Mismatch repair_Homo sapiens_hsa03430	1.02507566
41	Nucleotide excision repair_Homo sapiens_hsa03420	1.01922101
42	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.95448360
43	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.94550640
44	Fanconi anemia pathway_Homo sapiens_hsa03460	0.89548201
45	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.88750747
46	Sulfur metabolism_Homo sapiens_hsa00920	0.88539132
47	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.88014134
48	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.87039047
49	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.85549999
50	Cardiac muscle contraction_Homo sapiens_hsa04260	0.83452822
51	Tryptophan metabolism_Homo sapiens_hsa00380	0.83020905
52	Pyrimidine metabolism_Homo sapiens_hsa00240	0.80973513
53	Fat digestion and absorption_Homo sapiens_hsa04975	0.75613845
54	Base excision repair_Homo sapiens_hsa03410	0.75576031
55	Caffeine metabolism_Homo sapiens_hsa00232	0.72909429
56	Selenocompound metabolism_Homo sapiens_hsa00450	0.72177464
57	RNA transport_Homo sapiens_hsa03013	0.71907056
58	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.71773290
59	Purine metabolism_Homo sapiens_hsa00230	0.69949507
60	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.69793136
61	Spliceosome_Homo sapiens_hsa03040	0.69085484
62	Regulation of autophagy_Homo sapiens_hsa04140	0.69074447
63	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.68325312
64	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.65673332
65	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.63556648
66	Butanoate metabolism_Homo sapiens_hsa00650	0.62983992
67	Herpes simplex infection_Homo sapiens_hsa05168	0.62460481
68	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.60168961
69	DNA replication_Homo sapiens_hsa03030	0.60103217
70	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.59934193
71	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.59787580
72	Peroxisome_Homo sapiens_hsa04146	0.58810572
73	Fatty acid elongation_Homo sapiens_hsa00062	0.58012733
74	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.54633483
75	Sulfur relay system_Homo sapiens_hsa04122	0.54332932
76	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.50916994
77	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.48121646
78	Chemical carcinogenesis_Homo sapiens_hsa05204	0.48057705
79	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.43279447
80	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.43070386
81	Metabolic pathways_Homo sapiens_hsa01100	0.41894915
82	Measles_Homo sapiens_hsa05162	0.37775170
83	Toxoplasmosis_Homo sapiens_hsa05145	0.36302368
84	Olfactory transduction_Homo sapiens_hsa04740	0.33381377
85	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.31670978
86	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.31463934
87	Retinol metabolism_Homo sapiens_hsa00830	0.29810304
88	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.27642549
89	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.27583986
90	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.26665689
91	Collecting duct acid secretion_Homo sapiens_hsa04966	0.26490156
92	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.25834294
93	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.25180951
94	Legionellosis_Homo sapiens_hsa05134	0.24621203
95	African trypanosomiasis_Homo sapiens_hsa05143	0.23730899
96	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.22130660
97	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.21669527
98	Tuberculosis_Homo sapiens_hsa05152	0.21491118
99	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.19542679
100	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.17920266

EEF1A1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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