ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	6.21584697
2	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	5.16135005
3	cytidine metabolic process (GO:0046087)	4.42683429
4	cytidine catabolic process (GO:0006216)	4.42683429
5	cytidine deamination (GO:0009972)	4.42683429
6	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.24407316
7	ATP synthesis coupled proton transport (GO:0015986)	4.24407316
8	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.09084878
9	water-soluble vitamin biosynthetic process (GO:0042364)	3.86852671
10	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.86122654
11	mannosylation (GO:0097502)	3.77708181
12	ribosomal small subunit assembly (GO:0000028)	3.69827114
13	platelet dense granule organization (GO:0060155)	3.64628277
14	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.58920249
15	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.58920249
16	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.45706980
17	protein complex biogenesis (GO:0070271)	3.42952816
18	preassembly of GPI anchor in ER membrane (GO:0016254)	3.34276916
19	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.32756460
20	protein neddylation (GO:0045116)	3.31538328
21	sequestering of actin monomers (GO:0042989)	3.30111156
22	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.27670580
23	proteasome assembly (GO:0043248)	3.23686511
24	positive regulation of defense response to virus by host (GO:0002230)	3.18924695
25	GPI anchor metabolic process (GO:0006505)	3.15393945
26	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.11872434
27	behavioral response to nicotine (GO:0035095)	3.11853686
28	mitochondrial respiratory chain complex assembly (GO:0033108)	3.11523277
29	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.10718919
30	NADH dehydrogenase complex assembly (GO:0010257)	3.10718919
31	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.10718919
32	GPI anchor biosynthetic process (GO:0006506)	3.09222071
33	electron transport chain (GO:0022900)	3.07283580
34	respiratory electron transport chain (GO:0022904)	3.05318573
35	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.05241281
36	regulation of cellular amino acid metabolic process (GO:0006521)	3.04815345
37	maturation of SSU-rRNA (GO:0030490)	2.91848751
38	protein deneddylation (GO:0000338)	2.91625100
39	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.90784475
40	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.90541404
41	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.89491997
42	termination of RNA polymerase III transcription (GO:0006386)	2.89491997
43	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.89364268
44	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.88793735
45	GTP biosynthetic process (GO:0006183)	2.87891368
46	negative regulation of telomere maintenance (GO:0032205)	2.85011093
47	regulation of regulatory T cell differentiation (GO:0045589)	2.84556890
48	positive regulation of prostaglandin secretion (GO:0032308)	2.82717510
49	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.82453792
50	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.82211155
51	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.82211155
52	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.82211155
53	rRNA modification (GO:0000154)	2.81143647
54	cytochrome complex assembly (GO:0017004)	2.78559871
55	respiratory chain complex IV assembly (GO:0008535)	2.78103514
56	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.77043317
57	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.77043317
58	cullin deneddylation (GO:0010388)	2.76233248
59	L-fucose catabolic process (GO:0042355)	2.75667121
60	fucose catabolic process (GO:0019317)	2.75667121
61	L-fucose metabolic process (GO:0042354)	2.75667121
62	iron-sulfur cluster assembly (GO:0016226)	2.75251346
63	metallo-sulfur cluster assembly (GO:0031163)	2.75251346
64	cellular response to interleukin-15 (GO:0071350)	2.75163135
65	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	2.74020733
66	chaperone-mediated protein transport (GO:0072321)	2.71568829
67	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.70586649
68	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.69954031
69	regulation of T cell receptor signaling pathway (GO:0050856)	2.69373384
70	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.68819306
71	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.68819306
72	regulation of chronic inflammatory response (GO:0002676)	2.67669900
73	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.67284883
74	regulation of T cell mediated cytotoxicity (GO:0001914)	2.66013834
75	negative T cell selection (GO:0043383)	2.65562850
76	response to interferon-beta (GO:0035456)	2.64523373
77	piRNA metabolic process (GO:0034587)	2.63897532
78	indolalkylamine metabolic process (GO:0006586)	2.63134093
79	regulation of interleukin-8 secretion (GO:2000482)	2.61642893
80	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.61172365
81	regulation of isotype switching to IgG isotypes (GO:0048302)	2.59719992
82	positive regulation of interleukin-8 secretion (GO:2000484)	2.56392718
83	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.54984545
84	protein-cofactor linkage (GO:0018065)	2.53907649
85	ribosomal large subunit biogenesis (GO:0042273)	2.52473321
86	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.52136376
87	adenosine metabolic process (GO:0046085)	2.52087300
88	regulation of leukocyte mediated cytotoxicity (GO:0001910)	2.51739982
89	response to pheromone (GO:0019236)	2.51174337
90	base-excision repair, AP site formation (GO:0006285)	2.47412327
91	proton transport (GO:0015992)	2.47283170
92	indolalkylamine catabolic process (GO:0046218)	2.47283112
93	tryptophan catabolic process (GO:0006569)	2.47283112
94	indole-containing compound catabolic process (GO:0042436)	2.47283112
95	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.47270630
96	positive regulation of fatty acid transport (GO:2000193)	2.45522029
97	negative regulation of mast cell activation (GO:0033004)	2.44899676
98	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.44269116
99	negative regulation of ligase activity (GO:0051352)	2.44269116
100	mast cell activation (GO:0045576)	2.44170157

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.93332941
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.63312391
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.28048678
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.19120887
5	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.10430564
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.96125820
7	VDR_22108803_ChIP-Seq_LS180_Human	2.94962133
8	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.81811893
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.80950676
10	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.80884356
11	VDR_23849224_ChIP-Seq_CD4+_Human	2.62663734
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.52070119
13	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.47792302
14	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.37941840
15	ELK1_19687146_ChIP-ChIP_HELA_Human	2.31954500
16	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.22028326
17	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.20123182
18	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.16028649
19	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.03374120
20	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.01029907
21	FOXP3_21729870_ChIP-Seq_TREG_Human	1.98231295
22	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.95859577
23	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.95315905
24	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.92332386
25	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.89632591
26	IGF1R_20145208_ChIP-Seq_DFB_Human	1.83685182
27	MYC_18940864_ChIP-ChIP_HL60_Human	1.81577228
28	EWS_26573619_Chip-Seq_HEK293_Human	1.78552991
29	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.72230456
30	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.71338936
31	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.70489950
32	IRF1_19129219_ChIP-ChIP_H3396_Human	1.68002149
33	TAF15_26573619_Chip-Seq_HEK293_Human	1.64336822
34	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.57836847
35	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.56636912
36	TP53_22573176_ChIP-Seq_HFKS_Human	1.55194576
37	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.54433453
38	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.53716870
39	FUS_26573619_Chip-Seq_HEK293_Human	1.46989565
40	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.44824078
41	GATA3_26560356_Chip-Seq_TH2_Human	1.44407865
42	AR_20517297_ChIP-Seq_VCAP_Human	1.43506493
43	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.43238196
44	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.43238196
45	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.43014148
46	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.38998311
47	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.35825893
48	P300_19829295_ChIP-Seq_ESCs_Human	1.31701151
49	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.31219923
50	EZH2_22144423_ChIP-Seq_EOC_Human	1.30693732
51	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.28868681
52	NANOG_19829295_ChIP-Seq_ESCs_Human	1.25681337
53	SOX2_19829295_ChIP-Seq_ESCs_Human	1.25681337
54	ER_23166858_ChIP-Seq_MCF-7_Human	1.24380685
55	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.24327783
56	MYB_26560356_Chip-Seq_TH2_Human	1.23391516
57	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.23068614
58	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.21542257
59	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.20823096
60	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.18798575
61	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.18429012
62	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.17176393
63	NCOR_22424771_ChIP-Seq_293T_Human	1.15782927
64	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.14530060
65	CBP_20019798_ChIP-Seq_JUKART_Human	1.14530060
66	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.14336819
67	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.13629518
68	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.12958471
69	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.12208162
70	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.10739474
71	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.08764297
72	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.08463559
73	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.07530864
74	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.06629529
75	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.05222822
76	NANOG_20526341_ChIP-Seq_ESCs_Human	1.04659031
77	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.04527780
78	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.04148850
79	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.03992089
80	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.03693614
81	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.03389535
82	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.02893477
83	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.02872268
84	GATA3_27048872_Chip-Seq_THYMUS_Human	1.02216441
85	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.01849861
86	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.00941728
87	TAF2_19829295_ChIP-Seq_ESCs_Human	0.99957751
88	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.98333663
89	RUNX_20019798_ChIP-Seq_JUKART_Human	0.98141060
90	HOXB7_26014856_ChIP-Seq_BT474_Human	0.96975200
91	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.96688508
92	TTF2_22483619_ChIP-Seq_HELA_Human	0.96352337
93	E2F4_17652178_ChIP-ChIP_JURKAT_Human	0.96112219
94	ERG_20517297_ChIP-Seq_VCAP_Human	0.95874365
95	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.95620848
96	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.94555273
97	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.92628937
98	CIITA_25753668_ChIP-Seq_RAJI_Human	0.92427025
99	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.91843688
100	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.90758257

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	4.31259070
2	MP0006072_abnormal_retinal_apoptosis	3.17858038
3	MP0002102_abnormal_ear_morphology	2.71694713
4	MP0001835_abnormal_antigen_presentation	2.53084005
5	MP0008877_abnormal_DNA_methylation	2.41464000
6	MP0004147_increased_porphyrin_level	2.36331100
7	MP0002138_abnormal_hepatobiliary_system	2.18879715
8	MP0005084_abnormal_gallbladder_morpholo	2.03433575
9	MP0008875_abnormal_xenobiotic_pharmacok	1.99057505
10	MP0000372_irregular_coat_pigmentation	1.98885239
11	MP0008872_abnormal_physiological_respon	1.98602230
12	MP0009785_altered_susceptibility_to	1.96919660
13	MP0002736_abnormal_nociception_after	1.95872248
14	MP0001968_abnormal_touch/_nociception	1.91962649
15	MP0002148_abnormal_hypersensitivity_rea	1.90532064
16	MP0005645_abnormal_hypothalamus_physiol	1.85266077
17	MP0005551_abnormal_eye_electrophysiolog	1.78223823
18	MP0005075_abnormal_melanosome_morpholog	1.77238908
19	MP0000685_abnormal_immune_system	1.74421342
20	MP0003011_delayed_dark_adaptation	1.72496939
21	MP0001800_abnormal_humoral_immune	1.71559727
22	MP0005253_abnormal_eye_physiology	1.71110099
23	MP0006292_abnormal_olfactory_placode	1.70333270
24	MP0003763_abnormal_thymus_physiology	1.68946907
25	MP0004885_abnormal_endolymph	1.68074224
26	MP0003786_premature_aging	1.66731171
27	MP0002166_altered_tumor_susceptibility	1.66535143
28	MP0005000_abnormal_immune_tolerance	1.64631720
29	MP0002876_abnormal_thyroid_physiology	1.60166035
30	MP0003195_calcinosis	1.60097959
31	MP0002837_dystrophic_cardiac_calcinosis	1.58756338
32	MP0003724_increased_susceptibility_to	1.56004288
33	MP0002723_abnormal_immune_serum	1.49342102
34	MP0005646_abnormal_pituitary_gland	1.46828527
35	MP0002006_tumorigenesis	1.46566815
36	MP0003866_abnormal_defecation	1.42768558
37	MP0005360_urolithiasis	1.42175503
38	MP0003646_muscle_fatigue	1.41091963
39	MP0004142_abnormal_muscle_tone	1.39797934
40	MP0002163_abnormal_gland_morphology	1.38239886
41	MP0001819_abnormal_immune_cell	1.35490092
42	MP0005389_reproductive_system_phenotype	1.35125731
43	MP0002420_abnormal_adaptive_immunity	1.34255035
44	MP0004145_abnormal_muscle_electrophysio	1.33849504
45	MP0001919_abnormal_reproductive_system	1.30985914
46	MP0009333_abnormal_splenocyte_physiolog	1.30624556
47	MP0003880_abnormal_central_pattern	1.30219211
48	MP0005387_immune_system_phenotype	1.28072323
49	MP0001790_abnormal_immune_system	1.28072323
50	MP0008058_abnormal_DNA_repair	1.27044856
51	MP0002277_abnormal_respiratory_mucosa	1.27034686
52	MP0002452_abnormal_antigen_presenting	1.26093939
53	MP0001905_abnormal_dopamine_level	1.25164781
54	MP0009764_decreased_sensitivity_to	1.22030126
55	MP0003283_abnormal_digestive_organ	1.20629413
56	MP0003878_abnormal_ear_physiology	1.19342067
57	MP0005377_hearing/vestibular/ear_phenot	1.19342067
58	MP0002638_abnormal_pupillary_reflex	1.19056239
59	MP0001501_abnormal_sleep_pattern	1.13969654
60	MP0001986_abnormal_taste_sensitivity	1.12972922
61	MP0003718_maternal_effect	1.10483508
62	MP0009379_abnormal_foot_pigmentation	1.10254417
63	MP0003806_abnormal_nucleotide_metabolis	1.09695171
64	MP0005025_abnormal_response_to	1.08849619
65	MP0003252_abnormal_bile_duct	1.06751540
66	MP0002653_abnormal_ependyma_morphology	1.03849551
67	MP0010155_abnormal_intestine_physiology	1.03455861
68	MP0001529_abnormal_vocalization	1.00623309
69	MP0006276_abnormal_autonomic_nervous	1.00114975
70	MP0003436_decreased_susceptibility_to	0.98426037
71	MP0000689_abnormal_spleen_morphology	0.96889420
72	MP0005379_endocrine/exocrine_gland_phen	0.95742456
73	MP0001845_abnormal_inflammatory_respons	0.95246936
74	MP0002160_abnormal_reproductive_system	0.94663906
75	MP0002095_abnormal_skin_pigmentation	0.94477001
76	MP0000716_abnormal_immune_system	0.94314842
77	MP0001764_abnormal_homeostasis	0.92984698
78	MP0002938_white_spotting	0.91956375
79	MP0002272_abnormal_nervous_system	0.91553212
80	MP0005085_abnormal_gallbladder_physiolo	0.90894828
81	MP0002398_abnormal_bone_marrow	0.89281595
82	MP0008995_early_reproductive_senescence	0.88622816
83	MP0005410_abnormal_fertilization	0.87787379
84	MP0004742_abnormal_vestibular_system	0.84804359
85	MP0009745_abnormal_behavioral_response	0.84450625
86	MP0006036_abnormal_mitochondrial_physio	0.82069088
87	MP0005332_abnormal_amino_acid	0.81768696
88	MP0010386_abnormal_urinary_bladder	0.80173295
89	MP0005636_abnormal_mineral_homeostasis	0.79841121
90	MP0000631_abnormal_neuroendocrine_gland	0.79512252
91	MP0002751_abnormal_autonomic_nervous	0.77421254
92	MP0002722_abnormal_immune_system	0.77233110
93	MP0001873_stomach_inflammation	0.77188753
94	MP0005365_abnormal_bile_salt	0.77063846
95	MP0004133_heterotaxia	0.74985985
96	MP0003567_abnormal_fetal_cardiomyocyte	0.74589953
97	MP0001485_abnormal_pinna_reflex	0.73770164
98	MP0002234_abnormal_pharynx_morphology	0.73486833
99	MP0002405_respiratory_system_inflammati	0.72665514
100	MP0001765_abnormal_ion_homeostasis	0.72617925

Predicted human phenotypes

Rank	Gene Set	Z-score
1	IgG deficiency (HP:0004315)	4.00178706
2	Congenital stationary night blindness (HP:0007642)	3.52495901
3	Pancreatic cysts (HP:0001737)	3.48072106
4	Mitochondrial inheritance (HP:0001427)	3.44493759
5	Acute necrotizing encephalopathy (HP:0006965)	3.34062906
6	3-Methylglutaconic aciduria (HP:0003535)	3.20879475
7	Hepatocellular necrosis (HP:0001404)	3.17485227
8	Increased CSF lactate (HP:0002490)	3.16181376
9	True hermaphroditism (HP:0010459)	3.15361061
10	Pancreatic fibrosis (HP:0100732)	3.10066834
11	Methylmalonic acidemia (HP:0002912)	3.08048914
12	Hepatic necrosis (HP:0002605)	3.03572044
13	Abnormal mitochondria in muscle tissue (HP:0008316)	2.99509728
14	Abolished electroretinogram (ERG) (HP:0000550)	2.94146832
15	Progressive macrocephaly (HP:0004481)	2.85800225
16	Abnormality of the renal cortex (HP:0011035)	2.82471592
17	Increased hepatocellular lipid droplets (HP:0006565)	2.82387247
18	Molar tooth sign on MRI (HP:0002419)	2.81392961
19	Abnormality of midbrain morphology (HP:0002418)	2.81392961
20	Acute encephalopathy (HP:0006846)	2.81381883
21	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.81311158
22	Renal cortical cysts (HP:0000803)	2.80294749
23	Lipid accumulation in hepatocytes (HP:0006561)	2.80241554
24	Severe combined immunodeficiency (HP:0004430)	2.78612927
25	Elevated erythrocyte sedimentation rate (HP:0003565)	2.77820171
26	Hypoproteinemia (HP:0003075)	2.74014048
27	Methylmalonic aciduria (HP:0012120)	2.73388675
28	Aplastic anemia (HP:0001915)	2.67973358
29	Nephronophthisis (HP:0000090)	2.64671805
30	Abnormal rod and cone electroretinograms (HP:0008323)	2.63202451
31	Congenital, generalized hypertrichosis (HP:0004540)	2.61284246
32	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.53002255
33	Type II lissencephaly (HP:0007260)	2.49835437
34	Abnormality of the prostate (HP:0008775)	2.49427837
35	Increased serum lactate (HP:0002151)	2.48681580
36	Abnormality of T cell number (HP:0011839)	2.47664512
37	T lymphocytopenia (HP:0005403)	2.45875540
38	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.45597663
39	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.45597663
40	Thyroiditis (HP:0100646)	2.45160267
41	Short tibia (HP:0005736)	2.38663515
42	Stomatitis (HP:0010280)	2.38407733
43	Increased intramyocellular lipid droplets (HP:0012240)	2.29936870
44	Abnormality of B cell number (HP:0010975)	2.29895765
45	Aplasia/hypoplasia of the uterus (HP:0008684)	2.29361348
46	Decreased central vision (HP:0007663)	2.28338481
47	Medial flaring of the eyebrow (HP:0010747)	2.27232495
48	Attenuation of retinal blood vessels (HP:0007843)	2.27200524
49	Optic disc pallor (HP:0000543)	2.26454843
50	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.25474231
51	Cerebral edema (HP:0002181)	2.24090149
52	Stomach cancer (HP:0012126)	2.23181722
53	Prostate neoplasm (HP:0100787)	2.22048806
54	Lactic acidosis (HP:0003128)	2.19487037
55	Abnormality of T cells (HP:0002843)	2.18922604
56	Increased IgM level (HP:0003496)	2.18372518
57	Abnormality of the renal medulla (HP:0100957)	2.18151841
58	Abnormal number of erythroid precursors (HP:0012131)	2.15444387
59	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.13605776
60	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.13305847
61	Renal Fanconi syndrome (HP:0001994)	2.12623092
62	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.11328804
63	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.08604010
64	Dicarboxylic aciduria (HP:0003215)	2.08604010
65	Abnormality of the pons (HP:0007361)	2.08438879
66	Hypoplasia of the uterus (HP:0000013)	2.07766513
67	Combined immunodeficiency (HP:0005387)	2.06744590
68	Abnormality of eosinophils (HP:0001879)	2.06067534
69	Hypoplasia of the pons (HP:0012110)	2.02559315
70	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.02190497
71	Abnormality of alanine metabolism (HP:0010916)	2.02190497
72	Hyperalaninemia (HP:0003348)	2.02190497
73	Constricted visual fields (HP:0001133)	2.01326990
74	Colon cancer (HP:0003003)	2.01058369
75	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.00258511
76	Pancytopenia (HP:0001876)	1.99948049
77	Sclerocornea (HP:0000647)	1.99287755
78	Abnormal albumin level (HP:0012116)	1.99030610
79	Hypoalbuminemia (HP:0003073)	1.99030610
80	Abnormality of vitamin B metabolism (HP:0004340)	1.96981126
81	B lymphocytopenia (HP:0010976)	1.96939699
82	Increased muscle lipid content (HP:0009058)	1.96665717
83	Type I transferrin isoform profile (HP:0003642)	1.95386411
84	Abnormal biliary tract physiology (HP:0012439)	1.94790167
85	Bile duct proliferation (HP:0001408)	1.94790167
86	Abnormality of cells of the erythroid lineage (HP:0012130)	1.94096698
87	Lethargy (HP:0001254)	1.94017991
88	Pendular nystagmus (HP:0012043)	1.92183917
89	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.91916431
90	Asplenia (HP:0001746)	1.89013345
91	Exertional dyspnea (HP:0002875)	1.88147235
92	Absent thumb (HP:0009777)	1.87337534
93	Keratoconus (HP:0000563)	1.85370737
94	Increased corneal curvature (HP:0100692)	1.85370737
95	Respiratory failure (HP:0002878)	1.84933813
96	Glycosuria (HP:0003076)	1.84771299
97	Abnormality of urine glucose concentration (HP:0011016)	1.84771299
98	Reticulocytopenia (HP:0001896)	1.83360654
99	Hyperglycinemia (HP:0002154)	1.81188123
100	Abnormal drinking behavior (HP:0030082)	1.78995373

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	3.84880851
2	ZAK	3.26270455
3	TLK1	3.25149790
4	MAP4K2	3.05485070
5	TAOK3	2.91391561
6	VRK2	2.76413924
7	TESK2	2.65231089
8	NUAK1	2.61433477
9	BCKDK	2.53879409
10	ADRBK2	2.50455084
11	FRK	2.30028646
12	GRK1	2.20031189
13	KDR	2.12523826
14	VRK1	1.80578341
15	BUB1	1.67560209
16	STK16	1.67226717
17	WNK4	1.55350517
18	PINK1	1.55097719
19	BMPR1B	1.52191930
20	PASK	1.48785331
21	MST4	1.47931312
22	GRK6	1.44237797
23	CDK19	1.40701338
24	MAP3K12	1.39483445
25	ITK	1.37196003
26	TEC	1.35484504
27	TIE1	1.30424137
28	MAP4K1	1.26461574
29	TRIM28	1.24152571
30	WNK3	1.18758801
31	IKBKB	1.08548761
32	MAPKAPK3	1.07620124
33	LIMK1	1.00814258
34	CSNK1G3	1.00303211
35	KIT	0.99861527
36	DAPK1	0.99380862
37	ERBB3	0.98096922
38	SYK	0.92225908
39	IKBKE	0.91974028
40	OXSR1	0.90321618
41	EIF2AK3	0.89833990
42	FES	0.89122885
43	TAF1	0.88644996
44	SRPK1	0.85348738
45	CSNK1G2	0.85256253
46	CSNK1G1	0.84270083
47	CDK8	0.82641098
48	RPS6KA5	0.81922463
49	PRKCQ	0.80641359
50	INSRR	0.79815375
51	PHKG1	0.78217514
52	PHKG2	0.78217514
53	PLK3	0.76865796
54	DYRK2	0.76529522
55	CAMKK2	0.74991915
56	MYLK	0.73640022
57	DAPK2	0.73617317
58	GRK7	0.72496455
59	STK39	0.71124909
60	NME1	0.69717751
61	MAP2K7	0.68657124
62	MAP3K4	0.67660860
63	CSNK1A1L	0.67331375
64	LCK	0.65983477
65	PLK4	0.65186192
66	MAP2K2	0.64474234
67	PLK2	0.60764233
68	NEK1	0.59839838
69	TGFBR1	0.59719923
70	EIF2AK2	0.59643525
71	TSSK6	0.58515113
72	RPS6KA4	0.57762448
73	BCR	0.57145065
74	NME2	0.56888554
75	CSF1R	0.55703968
76	LYN	0.55648366
77	MAP3K14	0.53962625
78	ADRBK1	0.53688108
79	MUSK	0.52528145
80	PRKCE	0.50765340
81	IGF1R	0.50394726
82	BMPR2	0.50362833
83	BTK	0.50154129
84	MAPK13	0.49865145
85	PIM1	0.48167228
86	FLT3	0.47335064
87	MKNK1	0.46242560
88	ACVR1B	0.45168584
89	GRK5	0.44238269
90	JAK3	0.43588797
91	TESK1	0.42505493
92	CSNK2A1	0.39927520
93	DAPK3	0.39609840
94	MATK	0.37032191
95	MAP2K6	0.36063153
96	PIK3CG	0.35814631
97	CSNK1A1	0.35153939
98	PRKACA	0.35108263
99	SCYL2	0.34688050
100	AURKB	0.34423531

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.67872165
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.17270613
3	Primary immunodeficiency_Homo sapiens_hsa05340	2.87839173
4	Asthma_Homo sapiens_hsa05310	2.84968678
5	Ribosome_Homo sapiens_hsa03010	2.77837111
6	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.71322349
7	Allograft rejection_Homo sapiens_hsa05330	2.67395930
8	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.59813144
9	Protein export_Homo sapiens_hsa03060	2.58820360
10	Parkinsons disease_Homo sapiens_hsa05012	2.49372613
11	Graft-versus-host disease_Homo sapiens_hsa05332	2.44318721
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.41704100
13	Type I diabetes mellitus_Homo sapiens_hsa04940	2.27303720
14	RNA polymerase_Homo sapiens_hsa03020	2.19488705
15	Antigen processing and presentation_Homo sapiens_hsa04612	1.89472860
16	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.71184777
17	Phototransduction_Homo sapiens_hsa04744	1.63087370
18	Alzheimers disease_Homo sapiens_hsa05010	1.56752104
19	Huntingtons disease_Homo sapiens_hsa05016	1.52040855
20	Homologous recombination_Homo sapiens_hsa03440	1.49730220
21	RNA degradation_Homo sapiens_hsa03018	1.48728324
22	Sulfur metabolism_Homo sapiens_hsa00920	1.45936487
23	Linoleic acid metabolism_Homo sapiens_hsa00591	1.43204059
24	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.42203754
25	Nitrogen metabolism_Homo sapiens_hsa00910	1.40983714
26	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.37705588
27	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.36610620
28	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.35993881
29	Rheumatoid arthritis_Homo sapiens_hsa05323	1.34698337
30	Basal transcription factors_Homo sapiens_hsa03022	1.33003324
31	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.28352797
32	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.28077518
33	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.25993035
34	Propanoate metabolism_Homo sapiens_hsa00640	1.24844616
35	Cardiac muscle contraction_Homo sapiens_hsa04260	1.20391862
36	Caffeine metabolism_Homo sapiens_hsa00232	1.18902559
37	Fanconi anemia pathway_Homo sapiens_hsa03460	1.12044694
38	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.11989488
39	One carbon pool by folate_Homo sapiens_hsa00670	1.11318695
40	Tryptophan metabolism_Homo sapiens_hsa00380	1.07790234
41	Pyrimidine metabolism_Homo sapiens_hsa00240	1.07280620
42	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.03932673
43	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.00200885
44	Peroxisome_Homo sapiens_hsa04146	0.98645634
45	Spliceosome_Homo sapiens_hsa03040	0.98128567
46	Butanoate metabolism_Homo sapiens_hsa00650	0.95839137
47	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.95531486
48	Purine metabolism_Homo sapiens_hsa00230	0.93604442
49	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.92851355
50	Mismatch repair_Homo sapiens_hsa03430	0.92642302
51	Chemical carcinogenesis_Homo sapiens_hsa05204	0.88844387
52	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.88691084
53	Nucleotide excision repair_Homo sapiens_hsa03420	0.86926312
54	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.82526756
55	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.81869445
56	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.77623621
57	Regulation of autophagy_Homo sapiens_hsa04140	0.77090606
58	RNA transport_Homo sapiens_hsa03013	0.76874930
59	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.76089022
60	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.74647375
61	Ether lipid metabolism_Homo sapiens_hsa00565	0.71991922
62	Viral myocarditis_Homo sapiens_hsa05416	0.71707355
63	Retinol metabolism_Homo sapiens_hsa00830	0.71395828
64	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.70453281
65	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.66488229
66	Base excision repair_Homo sapiens_hsa03410	0.65179483
67	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.65022148
68	Non-homologous end-joining_Homo sapiens_hsa03450	0.64577404
69	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.61729640
70	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.60978324
71	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.60117530
72	Fat digestion and absorption_Homo sapiens_hsa04975	0.60001876
73	DNA replication_Homo sapiens_hsa03030	0.59445106
74	Metabolic pathways_Homo sapiens_hsa01100	0.59175990
75	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.54722535
76	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.54021238
77	Selenocompound metabolism_Homo sapiens_hsa00450	0.53677620
78	Olfactory transduction_Homo sapiens_hsa04740	0.52474962
79	Glutathione metabolism_Homo sapiens_hsa00480	0.49619272
80	Collecting duct acid secretion_Homo sapiens_hsa04966	0.48946810
81	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.48847865
82	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.47276702
83	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.47257603
84	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.47082896
85	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.46921727
86	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.44818551
87	Herpes simplex infection_Homo sapiens_hsa05168	0.42002199
88	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.41891825
89	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.40889647
90	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.40406374
91	Fatty acid elongation_Homo sapiens_hsa00062	0.40200217
92	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.38587252
93	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.38408010
94	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.37930084
95	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.35201350
96	Steroid biosynthesis_Homo sapiens_hsa00100	0.33865249
97	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.32374647
98	Taste transduction_Homo sapiens_hsa04742	0.28724992
99	Nicotine addiction_Homo sapiens_hsa05033	0.28120804
100	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.26659553

EEF1A1P10

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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