ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	6.13898527
2	ribosomal small subunit assembly (GO:0000028)	5.14606010
3	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.78199857
4	cytidine metabolic process (GO:0046087)	4.44084679
5	cytidine catabolic process (GO:0006216)	4.44084679
6	cytidine deamination (GO:0009972)	4.44084679
7	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.28068517
8	ATP synthesis coupled proton transport (GO:0015986)	4.21259608
9	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.21259608
10	proteasome assembly (GO:0043248)	4.05003483
11	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.88572958
12	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.88572958
13	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.74298868
14	water-soluble vitamin biosynthetic process (GO:0042364)	3.55562453
15	pseudouridine synthesis (GO:0001522)	3.52544049
16	protein complex biogenesis (GO:0070271)	3.46472345
17	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.40979574
18	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.36480746
19	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.31391720
20	regulation of cellular amino acid metabolic process (GO:0006521)	3.31344748
21	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.30122178
22	ribosomal large subunit biogenesis (GO:0042273)	3.28679933
23	maturation of SSU-rRNA (GO:0030490)	3.28334594
24	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.26906855
25	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.26667898
26	respiratory chain complex IV assembly (GO:0008535)	3.25588123
27	protein neddylation (GO:0045116)	3.24841697
28	viral transcription (GO:0019083)	3.22476713
29	cotranslational protein targeting to membrane (GO:0006613)	3.20252599
30	mitochondrial respiratory chain complex assembly (GO:0033108)	3.19834371
31	protein targeting to ER (GO:0045047)	3.19266091
32	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.15447694
33	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.14498503
34	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.14498503
35	NADH dehydrogenase complex assembly (GO:0010257)	3.14498503
36	translational elongation (GO:0006414)	3.13200146
37	translational termination (GO:0006415)	3.12705961
38	cytochrome complex assembly (GO:0017004)	3.09502961
39	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.07700784
40	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.07700784
41	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.07700784
42	protein localization to endoplasmic reticulum (GO:0070972)	3.04225070
43	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.04174088
44	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.03807525
45	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.03807525
46	rRNA modification (GO:0000154)	3.02095886
47	platelet dense granule organization (GO:0060155)	3.01428887
48	termination of RNA polymerase III transcription (GO:0006386)	3.01417971
49	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.01417971
50	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.00083501
51	respiratory electron transport chain (GO:0022904)	2.98672004
52	electron transport chain (GO:0022900)	2.98550083
53	translation (GO:0006412)	2.96900546
54	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.95772817
55	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.95772817
56	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.94090610
57	negative regulation of ligase activity (GO:0051352)	2.92631932
58	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.92631932
59	mannosylation (GO:0097502)	2.85955870
60	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.85933106
61	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.82935181
62	peptidyl-histidine modification (GO:0018202)	2.80589683
63	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.76027911
64	positive regulation of interleukin-17 production (GO:0032740)	2.75447095
65	positive regulation of defense response to virus by host (GO:0002230)	2.73960250
66	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.72440949
67	GTP biosynthetic process (GO:0006183)	2.71931485
68	negative regulation of mast cell activation (GO:0033004)	2.71575151
69	iron-sulfur cluster assembly (GO:0016226)	2.71389156
70	metallo-sulfur cluster assembly (GO:0031163)	2.71389156
71	preassembly of GPI anchor in ER membrane (GO:0016254)	2.70887133
72	response to interferon-beta (GO:0035456)	2.70600297
73	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	2.69735248
74	positive regulation of prostaglandin secretion (GO:0032308)	2.67115058
75	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.66464579
76	regulation of T cell receptor signaling pathway (GO:0050856)	2.65660555
77	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.63307640
78	cellular response to interleukin-15 (GO:0071350)	2.63207732
79	rRNA processing (GO:0006364)	2.62571673
80	Arp2/3 complex-mediated actin nucleation (GO:0034314)	2.60834270
81	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	2.59976652
82	rRNA metabolic process (GO:0016072)	2.59944168
83	purine-containing compound salvage (GO:0043101)	2.59005417
84	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.57599783
85	cellular component biogenesis (GO:0044085)	2.57007383
86	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.56050831
87	response to pheromone (GO:0019236)	2.56022601
88	translational initiation (GO:0006413)	2.55317045
89	chaperone-mediated protein transport (GO:0072321)	2.55183490
90	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	2.54453706
91	positive regulation of natural killer cell mediated immunity (GO:0002717)	2.54290578
92	regulation of regulatory T cell differentiation (GO:0045589)	2.54188476
93	GPI anchor metabolic process (GO:0006505)	2.52690348
94	GPI anchor biosynthetic process (GO:0006506)	2.50475587
95	regulation of activation of Janus kinase activity (GO:0010533)	2.49956151
96	actin nucleation (GO:0045010)	2.49889093
97	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.48802415
98	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.47433363
99	regulation of isotype switching to IgG isotypes (GO:0048302)	2.46781520
100	tRNA processing (GO:0008033)	2.46469345

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.21032070
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.94226204
3	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.64476222
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.54582001
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.44885301
6	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.36711870
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.96947202
8	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.96239708
9	VDR_23849224_ChIP-Seq_CD4+_Human	2.87314618
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.86869745
11	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.70354569
12	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.64695377
13	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.60801388
14	VDR_22108803_ChIP-Seq_LS180_Human	2.58694780
15	ZNF274_21170338_ChIP-Seq_K562_Hela	2.56401564
16	ELK1_19687146_ChIP-ChIP_HELA_Human	2.46048823
17	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.33498450
18	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.30192820
19	FOXP3_21729870_ChIP-Seq_TREG_Human	2.26539122
20	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.23190860
21	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.18951996
22	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.10540898
23	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.07163055
24	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.00264658
25	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.95408084
26	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.94139675
27	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.89449816
28	MYC_18940864_ChIP-ChIP_HL60_Human	1.85867662
29	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.83795707
30	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.81890457
31	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.68542717
32	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.64981789
33	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.61500896
34	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.58089102
35	EWS_26573619_Chip-Seq_HEK293_Human	1.52925264
36	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.51894111
37	GATA3_26560356_Chip-Seq_TH2_Human	1.49708081
38	MYB_26560356_Chip-Seq_TH2_Human	1.45088300
39	TP53_22573176_ChIP-Seq_HFKS_Human	1.44277305
40	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.44017467
41	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.43906245
42	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.42619734
43	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.41303326
44	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.37189702
45	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.36737406
46	AR_20517297_ChIP-Seq_VCAP_Human	1.35637728
47	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.35580832
48	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.34258803
49	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.34258803
50	IGF1R_20145208_ChIP-Seq_DFB_Human	1.31269574
51	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.27101213
52	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.23660912
53	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.22604188
54	FUS_26573619_Chip-Seq_HEK293_Human	1.22349558
55	TTF2_22483619_ChIP-Seq_HELA_Human	1.21769417
56	IRF1_19129219_ChIP-ChIP_H3396_Human	1.20873906
57	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.19007629
58	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.18941205
59	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.16604608
60	GABP_19822575_ChIP-Seq_HepG2_Human	1.16503176
61	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.16133733
62	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.13269702
63	DCP1A_22483619_ChIP-Seq_HELA_Human	1.12815424
64	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.12319782
65	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.11253386
66	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.09658148
67	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.05706306
68	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.05319918
69	NCOR_22424771_ChIP-Seq_293T_Human	1.04998590
70	SOX2_19829295_ChIP-Seq_ESCs_Human	1.04647266
71	NANOG_19829295_ChIP-Seq_ESCs_Human	1.04647266
72	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.04118801
73	GATA3_27048872_Chip-Seq_THYMUS_Human	1.02344417
74	ER_23166858_ChIP-Seq_MCF-7_Human	1.02301960
75	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.01315531
76	RUNX_20019798_ChIP-Seq_JUKART_Human	1.00512340
77	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.00409523
78	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.00157185
79	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.98693280
80	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.98216105
81	SPI1_23547873_ChIP-Seq_NB4_Human	0.98124784
82	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.97174714
83	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.97072240
84	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.97012628
85	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.96848891
86	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.96136106
87	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.95804457
88	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.95533275
89	NANOG_20526341_ChIP-Seq_ESCs_Human	0.95452708
90	CBP_20019798_ChIP-Seq_JUKART_Human	0.94953611
91	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.94953611
92	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.94749595
93	P300_19829295_ChIP-Seq_ESCs_Human	0.94599080
94	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.94391200
95	CIITA_25753668_ChIP-Seq_RAJI_Human	0.93390113
96	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.92631198
97	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.91922479
98	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.90616544
99	ERG_20517297_ChIP-Seq_VCAP_Human	0.90368208
100	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.89823326

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	4.40230282
2	MP0001835_abnormal_antigen_presentation	3.37827923
3	MP0003806_abnormal_nucleotide_metabolis	2.55313802
4	MP0009785_altered_susceptibility_to	2.49380315
5	MP0002138_abnormal_hepatobiliary_system	2.48200854
6	MP0009379_abnormal_foot_pigmentation	2.43619063
7	MP0002102_abnormal_ear_morphology	2.41081609
8	MP0006072_abnormal_retinal_apoptosis	2.32180071
9	MP0005084_abnormal_gallbladder_morpholo	2.29438859
10	MP0002163_abnormal_gland_morphology	2.26695372
11	MP0004147_increased_porphyrin_level	2.11277843
12	MP0003763_abnormal_thymus_physiology	2.11083126
13	MP0008877_abnormal_DNA_methylation	2.09416881
14	MP0002148_abnormal_hypersensitivity_rea	2.09272070
15	MP0002166_altered_tumor_susceptibility	2.06574574
16	MP0009333_abnormal_splenocyte_physiolog	2.05665291
17	MP0005000_abnormal_immune_tolerance	1.94983309
18	MP0001800_abnormal_humoral_immune	1.94015830
19	MP0008872_abnormal_physiological_respon	1.93195170
20	MP0005645_abnormal_hypothalamus_physiol	1.88343261
21	MP0003195_calcinosis	1.84920491
22	MP0002006_tumorigenesis	1.82162927
23	MP0008875_abnormal_xenobiotic_pharmacok	1.81037649
24	MP0000685_abnormal_immune_system	1.80469415
25	MP0000372_irregular_coat_pigmentation	1.80417745
26	MP0008058_abnormal_DNA_repair	1.77468106
27	MP0002723_abnormal_immune_serum	1.73191923
28	MP0003786_premature_aging	1.70542553
29	MP0005387_immune_system_phenotype	1.70382422
30	MP0001790_abnormal_immune_system	1.70382422
31	MP0005075_abnormal_melanosome_morpholog	1.68190962
32	MP0002420_abnormal_adaptive_immunity	1.65487151
33	MP0001819_abnormal_immune_cell	1.62856175
34	MP0006292_abnormal_olfactory_placode	1.57930399
35	MP0005379_endocrine/exocrine_gland_phen	1.54950670
36	MP0002452_abnormal_antigen_presenting	1.53922411
37	MP0002837_dystrophic_cardiac_calcinosis	1.52329399
38	MP0001873_stomach_inflammation	1.51587172
39	MP0005025_abnormal_response_to	1.47283107
40	MP0002876_abnormal_thyroid_physiology	1.46915993
41	MP0001968_abnormal_touch/_nociception	1.44461923
42	MP0005551_abnormal_eye_electrophysiolog	1.39459347
43	MP0002398_abnormal_bone_marrow	1.37534252
44	MP0003567_abnormal_fetal_cardiomyocyte	1.34158621
45	MP0000716_abnormal_immune_system	1.30677556
46	MP0003011_delayed_dark_adaptation	1.30275581
47	MP0001986_abnormal_taste_sensitivity	1.30193999
48	MP0005389_reproductive_system_phenotype	1.27451673
49	MP0000689_abnormal_spleen_morphology	1.27103291
50	MP0001764_abnormal_homeostasis	1.27054700
51	MP0004885_abnormal_endolymph	1.23625728
52	MP0003718_maternal_effect	1.22685823
53	MP0005253_abnormal_eye_physiology	1.21087898
54	MP0001845_abnormal_inflammatory_respons	1.20265025
55	MP0002277_abnormal_respiratory_mucosa	1.19734812
56	MP0002736_abnormal_nociception_after	1.18949852
57	MP0002405_respiratory_system_inflammati	1.16935935
58	MP0010155_abnormal_intestine_physiology	1.12452718
59	MP0001905_abnormal_dopamine_level	1.11957834
60	MP0003252_abnormal_bile_duct	1.11480564
61	MP0002722_abnormal_immune_system	1.11327563
62	MP0006036_abnormal_mitochondrial_physio	1.11182252
63	MP0003866_abnormal_defecation	1.10426369
64	MP0009764_decreased_sensitivity_to	1.09349860
65	MP0005360_urolithiasis	1.08823440
66	MP0006082_CNS_inflammation	1.08589841
67	MP0001919_abnormal_reproductive_system	1.07923960
68	MP0002693_abnormal_pancreas_physiology	1.07470816
69	MP0002429_abnormal_blood_cell	1.06778317
70	MP0002160_abnormal_reproductive_system	1.06291448
71	MP0010386_abnormal_urinary_bladder	1.06228951
72	MP0005646_abnormal_pituitary_gland	1.05410723
73	MP0003186_abnormal_redox_activity	1.02819468
74	MP0008469_abnormal_protein_level	1.00608291
75	MP0006054_spinal_hemorrhage	1.00031360
76	MP0008995_early_reproductive_senescence	0.97103084
77	MP0000703_abnormal_thymus_morphology	0.94586104
78	MP0005410_abnormal_fertilization	0.91910515
79	MP0005174_abnormal_tail_pigmentation	0.89901235
80	MP0001529_abnormal_vocalization	0.89083040
81	MP0010094_abnormal_chromosome_stability	0.87350519
82	MP0005636_abnormal_mineral_homeostasis	0.84651134
83	MP0005332_abnormal_amino_acid	0.84211632
84	MP0002419_abnormal_innate_immunity	0.82060241
85	MP0001119_abnormal_female_reproductive	0.81415861
86	MP0003646_muscle_fatigue	0.80836570
87	MP0009697_abnormal_copulation	0.80268472
88	MP0001853_heart_inflammation	0.80175803
89	MP0003693_abnormal_embryo_hatching	0.80079236
90	MP0004142_abnormal_muscle_tone	0.79108058
91	MP0003436_decreased_susceptibility_to	0.78671673
92	MP0003724_increased_susceptibility_to	0.77560617
93	MP0000465_gastrointestinal_hemorrhage	0.77226669
94	MP0002095_abnormal_skin_pigmentation	0.76996669
95	MP0002933_joint_inflammation	0.76136671
96	MP0005377_hearing/vestibular/ear_phenot	0.75605881
97	MP0003878_abnormal_ear_physiology	0.75605881
98	MP0006035_abnormal_mitochondrial_morpho	0.74940541
99	MP0002019_abnormal_tumor_incidence	0.73674926
100	MP0009643_abnormal_urine_homeostasis	0.73180744

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	3.94600167
2	Mitochondrial inheritance (HP:0001427)	3.88474201
3	IgG deficiency (HP:0004315)	3.68584552
4	Increased CSF lactate (HP:0002490)	3.57478546
5	Abnormal mitochondria in muscle tissue (HP:0008316)	3.45676349
6	Aplastic anemia (HP:0001915)	3.44615067
7	Congenital stationary night blindness (HP:0007642)	3.43599008
8	Acute encephalopathy (HP:0006846)	3.41882269
9	Progressive macrocephaly (HP:0004481)	3.33154814
10	Hepatocellular necrosis (HP:0001404)	3.30984530
11	Severe combined immunodeficiency (HP:0004430)	3.27409649
12	Increased hepatocellular lipid droplets (HP:0006565)	3.26742726
13	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.21125648
14	Abnormality of B cell number (HP:0010975)	3.16547975
15	Hypoproteinemia (HP:0003075)	3.16388098
16	Lipid accumulation in hepatocytes (HP:0006561)	3.12768919
17	Hepatic necrosis (HP:0002605)	3.09887714
18	Elevated erythrocyte sedimentation rate (HP:0003565)	3.07108896
19	Abnormal rod and cone electroretinograms (HP:0008323)	3.03680752
20	Renal Fanconi syndrome (HP:0001994)	3.03375828
21	3-Methylglutaconic aciduria (HP:0003535)	2.98845826
22	Abnormality of T cell number (HP:0011839)	2.95454784
23	Abolished electroretinogram (ERG) (HP:0000550)	2.92223562
24	Pancreatic cysts (HP:0001737)	2.88855474
25	T lymphocytopenia (HP:0005403)	2.84822359
26	B lymphocytopenia (HP:0010976)	2.81844641
27	Thyroiditis (HP:0100646)	2.78303777
28	Methylmalonic acidemia (HP:0002912)	2.76415527
29	Increased IgM level (HP:0003496)	2.70113366
30	Abnormality of T cells (HP:0002843)	2.66877821
31	Stomatitis (HP:0010280)	2.64764793
32	Abnormal number of erythroid precursors (HP:0012131)	2.64050867
33	Cerebral edema (HP:0002181)	2.62409285
34	Attenuation of retinal blood vessels (HP:0007843)	2.59307974
35	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.57737246
36	Autoimmune hemolytic anemia (HP:0001890)	2.56285278
37	Renal cortical cysts (HP:0000803)	2.55821127
38	Exertional dyspnea (HP:0002875)	2.54335722
39	Increased serum lactate (HP:0002151)	2.50324727
40	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.49605797
41	Optic disc pallor (HP:0000543)	2.49340150
42	Abnormality of cells of the erythroid lineage (HP:0012130)	2.48573071
43	Pancreatic fibrosis (HP:0100732)	2.48243036
44	Combined immunodeficiency (HP:0005387)	2.46777863
45	Abnormality of the prostate (HP:0008775)	2.46333200
46	Constricted visual fields (HP:0001133)	2.45144015
47	Methylmalonic aciduria (HP:0012120)	2.44828304
48	Abnormality of the renal cortex (HP:0011035)	2.43592879
49	True hermaphroditism (HP:0010459)	2.39329108
50	Abnormality of eosinophils (HP:0001879)	2.37267388
51	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.34978272
52	Increased intramyocellular lipid droplets (HP:0012240)	2.34459276
53	Pancytopenia (HP:0001876)	2.33722167
54	Panhypogammaglobulinemia (HP:0003139)	2.33307102
55	Lactic acidosis (HP:0003128)	2.31251036
56	Generalized aminoaciduria (HP:0002909)	2.28073731
57	Reticulocytopenia (HP:0001896)	2.25035974
58	Pendular nystagmus (HP:0012043)	2.24399931
59	Abnormality of T cell physiology (HP:0011840)	2.23698017
60	Congenital, generalized hypertrichosis (HP:0004540)	2.21770831
61	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.21534143
62	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.21534143
63	Decreased central vision (HP:0007663)	2.21259646
64	Molar tooth sign on MRI (HP:0002419)	2.19391462
65	Abnormality of midbrain morphology (HP:0002418)	2.19391462
66	Oral leukoplakia (HP:0002745)	2.18038054
67	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.12410367
68	Type I transferrin isoform profile (HP:0003642)	2.09725984
69	Lethargy (HP:0001254)	2.08474328
70	Hypothermia (HP:0002045)	2.06689783
71	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.06542897
72	Dicarboxylic aciduria (HP:0003215)	2.06542897
73	Prostate neoplasm (HP:0100787)	2.05897905
74	Respiratory failure (HP:0002878)	2.05743398
75	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.04286107
76	Abnormal protein N-linked glycosylation (HP:0012347)	2.04286107
77	Abnormal protein glycosylation (HP:0012346)	2.04286107
78	Abnormal glycosylation (HP:0012345)	2.04286107
79	Eosinophilia (HP:0001880)	2.02432764
80	Glycosuria (HP:0003076)	2.01692174
81	Abnormality of urine glucose concentration (HP:0011016)	2.01692174
82	Nephronophthisis (HP:0000090)	2.00029386
83	Chronic diarrhea (HP:0002028)	1.96771772
84	Hyperglycinemia (HP:0002154)	1.95648765
85	Increased muscle lipid content (HP:0009058)	1.95253872
86	Neutropenia (HP:0001875)	1.94934789
87	Macrocytic anemia (HP:0001972)	1.93311073
88	Aplasia/hypoplasia of the uterus (HP:0008684)	1.91819458
89	Colon cancer (HP:0003003)	1.90129449
90	Absent thumb (HP:0009777)	1.88142073
91	Abnormality of alanine metabolism (HP:0010916)	1.87699716
92	Hyperalaninemia (HP:0003348)	1.87699716
93	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.87699716
94	Keratoconus (HP:0000563)	1.87557532
95	Increased corneal curvature (HP:0100692)	1.87557532
96	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.85470559
97	Abnormal biliary tract physiology (HP:0012439)	1.82692058
98	Bile duct proliferation (HP:0001408)	1.82692058
99	Type 2 muscle fiber atrophy (HP:0003554)	1.82544522
100	Recurrent cutaneous fungal infections (HP:0011370)	1.80115015

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	3.95023156
2	ZAK	3.68358811
3	VRK2	3.38602030
4	TLK1	3.37294311
5	KDR	2.76935644
6	ADRBK2	2.70173288
7	MAP4K2	2.61281037
8	NUAK1	2.38436725
9	TAOK3	2.32553465
10	GRK1	2.22927697
11	VRK1	2.17571369
12	TESK2	2.16863421
13	BUB1	2.10199941
14	MAP3K12	2.05596675
15	MST4	2.05449280
16	EIF2AK3	1.96455578
17	BCKDK	1.88332290
18	PASK	1.80063066
19	FRK	1.76868264
20	MAP4K1	1.70178763
21	CDK19	1.47577821
22	TIE1	1.44491728
23	KIT	1.43761160
24	STK16	1.42895097
25	ITK	1.40852731
26	TRIM28	1.39309979
27	TEC	1.39170765
28	MYLK	1.37592156
29	FLT3	1.36493884
30	BMPR1B	1.27639451
31	FES	1.27389475
32	TAF1	1.25975999
33	IKBKB	1.24033397
34	PBK	1.11755911
35	PINK1	1.09429986
36	MAP2K6	1.01975183
37	LIMK1	1.00989271
38	SCYL2	1.00938529
39	DAPK1	0.98649299
40	SYK	0.96591817
41	BMPR2	0.96305467
42	WNK4	0.90063726
43	INSRR	0.85820986
44	GRK6	0.84253904
45	CSNK1G3	0.84245581
46	ZAP70	0.80846026
47	LCK	0.80401138
48	PRKCQ	0.79948996
49	WNK3	0.79480768
50	RPS6KA5	0.77881432
51	OXSR1	0.77104034
52	MUSK	0.75250348
53	STK38L	0.74032207
54	CSNK1G1	0.73818577
55	CDK8	0.73789504
56	JAK3	0.73384388
57	PLK3	0.71930070
58	CSF1R	0.71464286
59	SRPK1	0.69837299
60	IKBKE	0.69593742
61	DAPK3	0.66259291
62	LYN	0.65920135
63	BTK	0.63314183
64	NME1	0.61337839
65	MKNK1	0.60562654
66	NME2	0.60523004
67	RPS6KA4	0.59820312
68	DYRK2	0.58211279
69	CSNK1G2	0.56958479
70	PIK3CG	0.53879456
71	ADRBK1	0.53681592
72	STK39	0.51070378
73	MATK	0.50991999
74	GRK7	0.50401464
75	IGF1R	0.50222606
76	CSNK1A1L	0.50220525
77	TGFBR1	0.49402092
78	ERBB4	0.49339460
79	CDC7	0.47435516
80	PLK4	0.46343759
81	ATR	0.45385721
82	DAPK2	0.43917577
83	MAP3K14	0.42932731
84	NEK1	0.42097210
85	PIM1	0.41686698
86	TSSK6	0.41618218
87	PRKCE	0.41500935
88	TNK2	0.41244520
89	MAPKAPK3	0.40847283
90	EIF2AK1	0.40016743
91	PLK1	0.39902261
92	EIF2AK2	0.39808221
93	CLK1	0.39759876
94	CAMKK2	0.38689568
95	MAPKAPK5	0.38280356
96	CSNK2A1	0.37306231
97	CSNK2A2	0.37139532
98	ILK	0.36625359
99	AURKB	0.35189771
100	TBK1	0.31151934

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.19502903
2	Ribosome_Homo sapiens_hsa03010	3.38921438
3	Primary immunodeficiency_Homo sapiens_hsa05340	3.20913131
4	Oxidative phosphorylation_Homo sapiens_hsa00190	3.12099121
5	Protein export_Homo sapiens_hsa03060	2.58687543
6	Parkinsons disease_Homo sapiens_hsa05012	2.56605973
7	Allograft rejection_Homo sapiens_hsa05330	2.45936432
8	RNA polymerase_Homo sapiens_hsa03020	2.43699951
9	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.28686692
10	Graft-versus-host disease_Homo sapiens_hsa05332	2.26855296
11	Asthma_Homo sapiens_hsa05310	2.23913640
12	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.16641869
13	Type I diabetes mellitus_Homo sapiens_hsa04940	2.11549669
14	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.98637471
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.93001447
16	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.88835189
17	Antigen processing and presentation_Homo sapiens_hsa04612	1.82303468
18	Homologous recombination_Homo sapiens_hsa03440	1.64845851
19	Alzheimers disease_Homo sapiens_hsa05010	1.58567649
20	Phototransduction_Homo sapiens_hsa04744	1.55461754
21	Huntingtons disease_Homo sapiens_hsa05016	1.51593270
22	RNA degradation_Homo sapiens_hsa03018	1.45519193
23	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.43396493
24	One carbon pool by folate_Homo sapiens_hsa00670	1.41825089
25	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.41051531
26	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.40399319
27	Basal transcription factors_Homo sapiens_hsa03022	1.39728243
28	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.37864293
29	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.35370461
30	Linoleic acid metabolism_Homo sapiens_hsa00591	1.32820356
31	Pyrimidine metabolism_Homo sapiens_hsa00240	1.31400664
32	Nitrogen metabolism_Homo sapiens_hsa00910	1.27358007
33	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.26837382
34	Rheumatoid arthritis_Homo sapiens_hsa05323	1.24603386
35	Sulfur metabolism_Homo sapiens_hsa00920	1.24224519
36	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.19076277
37	Fanconi anemia pathway_Homo sapiens_hsa03460	1.17931280
38	Spliceosome_Homo sapiens_hsa03040	1.14751198
39	DNA replication_Homo sapiens_hsa03030	1.11601092
40	Nucleotide excision repair_Homo sapiens_hsa03420	1.06375379
41	Mismatch repair_Homo sapiens_hsa03430	1.06156076
42	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.04390816
43	RNA transport_Homo sapiens_hsa03013	1.04097786
44	Propanoate metabolism_Homo sapiens_hsa00640	1.03280994
45	Purine metabolism_Homo sapiens_hsa00230	0.99305452
46	Selenocompound metabolism_Homo sapiens_hsa00450	0.99290916
47	Butanoate metabolism_Homo sapiens_hsa00650	0.98057695
48	Caffeine metabolism_Homo sapiens_hsa00232	0.97274339
49	Peroxisome_Homo sapiens_hsa04146	0.94261239
50	Cardiac muscle contraction_Homo sapiens_hsa04260	0.92132017
51	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.91781649
52	Base excision repair_Homo sapiens_hsa03410	0.91245121
53	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.88453859
54	Non-homologous end-joining_Homo sapiens_hsa03450	0.84603689
55	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.81634090
56	Glutathione metabolism_Homo sapiens_hsa00480	0.79055362
57	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.78993340
58	Tryptophan metabolism_Homo sapiens_hsa00380	0.78002855
59	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.77029224
60	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.73713566
61	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.70911348
62	Chemical carcinogenesis_Homo sapiens_hsa05204	0.69396119
63	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.69336242
64	Ether lipid metabolism_Homo sapiens_hsa00565	0.67452766
65	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.67416272
66	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.67081494
67	Viral myocarditis_Homo sapiens_hsa05416	0.64497483
68	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.62799876
69	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.61871562
70	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.61369985
71	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.59361145
72	Metabolic pathways_Homo sapiens_hsa01100	0.57687305
73	Retinol metabolism_Homo sapiens_hsa00830	0.57198602
74	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.56237341
75	Regulation of autophagy_Homo sapiens_hsa04140	0.53250062
76	Fat digestion and absorption_Homo sapiens_hsa04975	0.53127840
77	Collecting duct acid secretion_Homo sapiens_hsa04966	0.51310892
78	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.50068641
79	Olfactory transduction_Homo sapiens_hsa04740	0.49718489
80	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.49495206
81	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.48874084
82	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.48248775
83	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.45504237
84	Measles_Homo sapiens_hsa05162	0.45030480
85	Herpes simplex infection_Homo sapiens_hsa05168	0.44940577
86	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.43839693
87	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.43060955
88	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.42087944
89	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.41861461
90	Fatty acid elongation_Homo sapiens_hsa00062	0.40025979
91	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.38964249
92	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.38821358
93	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.37863494
94	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.36754514
95	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.35040180
96	Taste transduction_Homo sapiens_hsa04742	0.33086967
97	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.32329100
98	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.30894390
99	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.30493411
100	Leishmaniasis_Homo sapiens_hsa05140	0.30275201

EEF1A1P11

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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