ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ATP synthesis coupled proton transport (GO:0015986)	5.27320304
2	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.27320304
3	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.94295977
4	ribosomal small subunit assembly (GO:0000028)	4.89464590
5	DNA deamination (GO:0045006)	4.60382248
6	water-soluble vitamin biosynthetic process (GO:0042364)	4.13320463
7	viral transcription (GO:0019083)	4.08462643
8	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.98411447
9	protein neddylation (GO:0045116)	3.94101734
10	translational termination (GO:0006415)	3.92196555
11	protein complex biogenesis (GO:0070271)	3.91351943
12	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.82938291
13	chaperone-mediated protein transport (GO:0072321)	3.77379309
14	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.77370656
15	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.77370656
16	ribosomal large subunit biogenesis (GO:0042273)	3.76734290
17	cotranslational protein targeting to membrane (GO:0006613)	3.76502717
18	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.74680777
19	NADH dehydrogenase complex assembly (GO:0010257)	3.74680777
20	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.74680777
21	translational elongation (GO:0006414)	3.72838524
22	protein targeting to ER (GO:0045047)	3.72634064
23	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.70567241
24	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.68853558
25	proteasome assembly (GO:0043248)	3.64366896
26	mitochondrial respiratory chain complex assembly (GO:0033108)	3.59781498
27	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.58943923
28	protein localization to endoplasmic reticulum (GO:0070972)	3.56479759
29	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.53421632
30	electron transport chain (GO:0022900)	3.47436917
31	respiratory electron transport chain (GO:0022904)	3.47419068
32	GTP biosynthetic process (GO:0006183)	3.41971008
33	maturation of SSU-rRNA (GO:0030490)	3.35043630
34	respiratory chain complex IV assembly (GO:0008535)	3.34126464
35	translation (GO:0006412)	3.26122986
36	rRNA modification (GO:0000154)	3.18837704
37	cytochrome complex assembly (GO:0017004)	3.14928021
38	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.11875636
39	translational initiation (GO:0006413)	3.09999247
40	positive regulation of prostaglandin secretion (GO:0032308)	3.09857961
41	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.09510784
42	regulation of cellular amino acid metabolic process (GO:0006521)	3.08586861
43	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.02697193
44	ATP biosynthetic process (GO:0006754)	2.99260187
45	viral life cycle (GO:0019058)	2.99161025
46	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.94671246
47	cullin deneddylation (GO:0010388)	2.91720148
48	protein deneddylation (GO:0000338)	2.91018318
49	termination of RNA polymerase III transcription (GO:0006386)	2.90929150
50	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.90929150
51	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.89404021
52	cellular protein complex disassembly (GO:0043624)	2.89149912
53	cellular component biogenesis (GO:0044085)	2.87791384
54	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.86871633
55	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.86871633
56	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.86871633
57	pseudouridine synthesis (GO:0001522)	2.86139994
58	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.82027333
59	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.82027333
60	L-fucose metabolic process (GO:0042354)	2.81570185
61	L-fucose catabolic process (GO:0042355)	2.81570185
62	fucose catabolic process (GO:0019317)	2.81570185
63	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.81224063
64	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.79218771
65	mannosylation (GO:0097502)	2.78690358
66	protein-cofactor linkage (GO:0018065)	2.78052926
67	hydrogen ion transmembrane transport (GO:1902600)	2.77112119
68	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.76810998
69	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.76810998
70	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.76107031
71	cytidine metabolic process (GO:0046087)	2.75961938
72	cytidine catabolic process (GO:0006216)	2.75961938
73	cytidine deamination (GO:0009972)	2.75961938
74	UTP biosynthetic process (GO:0006228)	2.74056886
75	ribosomal small subunit biogenesis (GO:0042274)	2.73332903
76	proton transport (GO:0015992)	2.73111420
77	platelet dense granule organization (GO:0060155)	2.70256755
78	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.70126818
79	peptidyl-histidine modification (GO:0018202)	2.69849193
80	tRNA processing (GO:0008033)	2.67568493
81	hydrogen transport (GO:0006818)	2.67185911
82	rRNA processing (GO:0006364)	2.66634001
83	rRNA metabolic process (GO:0016072)	2.66204579
84	GDP-mannose metabolic process (GO:0019673)	2.65797173
85	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.63581684
86	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.62841693
87	maturation of 5.8S rRNA (GO:0000460)	2.62824349
88	behavioral response to nicotine (GO:0035095)	2.62599089
89	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.62290020
90	negative regulation of ligase activity (GO:0051352)	2.62290020
91	UTP metabolic process (GO:0046051)	2.59994236
92	ribonucleoprotein complex biogenesis (GO:0022613)	2.56851757
93	rRNA methylation (GO:0031167)	2.56849342
94	indolalkylamine metabolic process (GO:0006586)	2.54767805
95	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.54734015
96	positive regulation of respiratory burst (GO:0060267)	2.53360639
97	sulfation (GO:0051923)	2.53354626
98	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.52914827
99	oxidative phosphorylation (GO:0006119)	2.52151773
100	rRNA catabolic process (GO:0016075)	2.51749263

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.52610293
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.33636248
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.83152289
4	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.49380659
5	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.47470955
6	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.27863744
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.19455389
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.15319514
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.86710927
10	ZNF274_21170338_ChIP-Seq_K562_Hela	2.86204212
11	VDR_22108803_ChIP-Seq_LS180_Human	2.74539379
12	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.71526066
13	VDR_23849224_ChIP-Seq_CD4+_Human	2.69020319
14	ELK1_19687146_ChIP-ChIP_HELA_Human	2.40677957
15	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.24558966
16	FOXP3_21729870_ChIP-Seq_TREG_Human	2.19758814
17	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.10960473
18	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.08079474
19	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.04803195
20	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.04130436
21	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.00302707
22	MYC_18940864_ChIP-ChIP_HL60_Human	1.99925292
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.99117716
24	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.98404163
25	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.85465708
26	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.73043547
27	IRF1_19129219_ChIP-ChIP_H3396_Human	1.68111851
28	EWS_26573619_Chip-Seq_HEK293_Human	1.66956267
29	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.63280458
30	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.59339429
31	FUS_26573619_Chip-Seq_HEK293_Human	1.57528032
32	IGF1R_20145208_ChIP-Seq_DFB_Human	1.56123940
33	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.55116802
34	TTF2_22483619_ChIP-Seq_HELA_Human	1.54089625
35	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.50927648
36	TP53_22573176_ChIP-Seq_HFKS_Human	1.48655035
37	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.45958216
38	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.42793667
39	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.42526885
40	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.42422476
41	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.42422476
42	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.40611792
43	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.39088507
44	AR_20517297_ChIP-Seq_VCAP_Human	1.36629765
45	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.34741325
46	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.31907414
47	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.30636333
48	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.30457581
49	DCP1A_22483619_ChIP-Seq_HELA_Human	1.28629758
50	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.26944880
51	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.26444771
52	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.23506473
53	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.22296247
54	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.20145621
55	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.19866064
56	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.19773706
57	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.17701834
58	GABP_19822575_ChIP-Seq_HepG2_Human	1.17377889
59	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.17160709
60	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.16034272
61	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.15506858
62	P300_19829295_ChIP-Seq_ESCs_Human	1.14737218
63	NCOR_22424771_ChIP-Seq_293T_Human	1.13913112
64	TAF15_26573619_Chip-Seq_HEK293_Human	1.13440222
65	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.13385402
66	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.12230240
67	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.11580029
68	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.10664430
69	SOX2_19829295_ChIP-Seq_ESCs_Human	1.10603938
70	NANOG_19829295_ChIP-Seq_ESCs_Human	1.10603938
71	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.10352684
72	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.10218611
73	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.10175567
74	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.07858751
75	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.07772331
76	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.07108058
77	NANOG_20526341_ChIP-Seq_ESCs_Human	1.06639743
78	ERG_20517297_ChIP-Seq_VCAP_Human	1.05737586
79	CBP_20019798_ChIP-Seq_JUKART_Human	1.05461804
80	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.05461804
81	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.05214591
82	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.03650463
83	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.02274512
84	XRN2_22483619_ChIP-Seq_HELA_Human	1.01350968
85	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.01204695
86	ER_23166858_ChIP-Seq_MCF-7_Human	0.99621065
87	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.97476672
88	GATA3_26560356_Chip-Seq_TH2_Human	0.97300983
89	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.97044545
90	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.96127219
91	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.94183422
92	TAF2_19829295_ChIP-Seq_ESCs_Human	0.92768698
93	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.92258756
94	MYC_19829295_ChIP-Seq_ESCs_Human	0.91470975
95	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.91347354
96	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.90731396
97	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.89932574
98	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.88557168
99	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.88467070
100	HOXB7_26014856_ChIP-Seq_BT474_Human	0.88184985

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	3.31549969
2	MP0005360_urolithiasis	3.20757330
3	MP0006292_abnormal_olfactory_placode	3.16979375
4	MP0005671_abnormal_response_to	2.78800700
5	MP0004147_increased_porphyrin_level	2.75701483
6	MP0002102_abnormal_ear_morphology	2.56312084
7	MP0008877_abnormal_DNA_methylation	2.41181613
8	MP0006072_abnormal_retinal_apoptosis	2.38880340
9	MP0001835_abnormal_antigen_presentation	2.34865002
10	MP0008875_abnormal_xenobiotic_pharmacok	2.32549143
11	MP0008872_abnormal_physiological_respon	2.22486663
12	MP0005645_abnormal_hypothalamus_physiol	2.10303319
13	MP0003806_abnormal_nucleotide_metabolis	2.10135937
14	MP0005084_abnormal_gallbladder_morpholo	2.08158824
15	MP0003718_maternal_effect	2.00413907
16	MP0002138_abnormal_hepatobiliary_system	1.95092719
17	MP0005085_abnormal_gallbladder_physiolo	1.88707130
18	MP0002876_abnormal_thyroid_physiology	1.83489006
19	MP0001529_abnormal_vocalization	1.82414405
20	MP0002736_abnormal_nociception_after	1.81501796
21	MP0002938_white_spotting	1.79307687
22	MP0002638_abnormal_pupillary_reflex	1.77149409
23	MP0008058_abnormal_DNA_repair	1.70857877
24	MP0001968_abnormal_touch/_nociception	1.67856759
25	MP0004885_abnormal_endolymph	1.64952870
26	MP0002163_abnormal_gland_morphology	1.53801475
27	MP0003195_calcinosis	1.51957907
28	MP0001873_stomach_inflammation	1.50410735
29	MP0001764_abnormal_homeostasis	1.50090880
30	MP0010155_abnormal_intestine_physiology	1.49214799
31	MP0002139_abnormal_hepatobiliary_system	1.45157572
32	MP0002148_abnormal_hypersensitivity_rea	1.44814395
33	MP0009785_altered_susceptibility_to	1.42383310
34	MP0004145_abnormal_muscle_electrophysio	1.40561247
35	MP0002277_abnormal_respiratory_mucosa	1.40211003
36	MP0005389_reproductive_system_phenotype	1.33467610
37	MP0002166_altered_tumor_susceptibility	1.33454026
38	MP0002006_tumorigenesis	1.33011535
39	MP0001666_abnormal_nutrient_absorption	1.31267682
40	MP0000685_abnormal_immune_system	1.30470345
41	MP0004142_abnormal_muscle_tone	1.30444186
42	MP0005551_abnormal_eye_electrophysiolog	1.27898543
43	MP0005332_abnormal_amino_acid	1.27180459
44	MP0005075_abnormal_melanosome_morpholog	1.25952968
45	MP0008789_abnormal_olfactory_epithelium	1.24714975
46	MP0001919_abnormal_reproductive_system	1.24237724
47	MP0005253_abnormal_eye_physiology	1.23764223
48	MP0005365_abnormal_bile_salt	1.23710985
49	MP0002837_dystrophic_cardiac_calcinosis	1.23171423
50	MP0003011_delayed_dark_adaptation	1.21045431
51	MP0003693_abnormal_embryo_hatching	1.20753115
52	MP0009764_decreased_sensitivity_to	1.20054785
53	MP0003186_abnormal_redox_activity	1.19321208
54	MP0003252_abnormal_bile_duct	1.18609353
55	MP0003787_abnormal_imprinting	1.16702056
56	MP0001800_abnormal_humoral_immune	1.15568173
57	MP0005646_abnormal_pituitary_gland	1.14818046
58	MP0003646_muscle_fatigue	1.14308213
59	MP0002160_abnormal_reproductive_system	1.13564118
60	MP0003866_abnormal_defecation	1.12020470
61	MP0003786_premature_aging	1.11076550
62	MP0000372_irregular_coat_pigmentation	1.09692178
63	MP0005387_immune_system_phenotype	1.09296669
64	MP0001790_abnormal_immune_system	1.09296669
65	MP0001986_abnormal_taste_sensitivity	1.08557045
66	MP0004019_abnormal_vitamin_homeostasis	1.08422206
67	MP0001905_abnormal_dopamine_level	1.06587779
68	MP0006036_abnormal_mitochondrial_physio	0.98379531
69	MP0005000_abnormal_immune_tolerance	0.96725595
70	MP0005379_endocrine/exocrine_gland_phen	0.95276486
71	MP0004957_abnormal_blastocyst_morpholog	0.92536964
72	MP0005636_abnormal_mineral_homeostasis	0.91247450
73	MP0000538_abnormal_urinary_bladder	0.90378835
74	MP0003567_abnormal_fetal_cardiomyocyte	0.89377637
75	MP0001845_abnormal_inflammatory_respons	0.86772906
76	MP0002723_abnormal_immune_serum	0.86586619
77	MP0005410_abnormal_fertilization	0.85684642
78	MP0000490_abnormal_crypts_of	0.85350725
79	MP0001485_abnormal_pinna_reflex	0.84665304
80	MP0003283_abnormal_digestive_organ	0.84562084
81	MP0010386_abnormal_urinary_bladder	0.84243643
82	MP0009333_abnormal_splenocyte_physiolog	0.83075508
83	MP0002822_catalepsy	0.83015276
84	MP0000631_abnormal_neuroendocrine_gland	0.81220526
85	MP0002272_abnormal_nervous_system	0.78827523
86	MP0002751_abnormal_autonomic_nervous	0.78660553
87	MP0006276_abnormal_autonomic_nervous	0.78228732
88	MP0002452_abnormal_antigen_presenting	0.78073446
89	MP0002420_abnormal_adaptive_immunity	0.78060870
90	MP0001819_abnormal_immune_cell	0.78000560
91	MP0009697_abnormal_copulation	0.77377859
92	MP0009643_abnormal_urine_homeostasis	0.76183934
93	MP0002234_abnormal_pharynx_morphology	0.75614402
94	MP0003724_increased_susceptibility_to	0.74191368
95	MP0001663_abnormal_digestive_system	0.74167755
96	MP0000427_abnormal_hair_cycle	0.73620463
97	MP0000049_abnormal_middle_ear	0.73555444
98	MP0002693_abnormal_pancreas_physiology	0.72653316
99	MP0000613_abnormal_salivary_gland	0.70547788
100	MP0001119_abnormal_female_reproductive	0.70028461

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.26578181
2	Mitochondrial inheritance (HP:0001427)	4.06644937
3	Acute encephalopathy (HP:0006846)	3.86700457
4	Increased hepatocellular lipid droplets (HP:0006565)	3.77433851
5	Increased CSF lactate (HP:0002490)	3.77126152
6	Abnormal mitochondria in muscle tissue (HP:0008316)	3.71633468
7	Lipid accumulation in hepatocytes (HP:0006561)	3.63187530
8	Progressive macrocephaly (HP:0004481)	3.61618908
9	Hepatocellular necrosis (HP:0001404)	3.46719048
10	Hepatic necrosis (HP:0002605)	3.37081023
11	3-Methylglutaconic aciduria (HP:0003535)	3.23584914
12	Congenital, generalized hypertrichosis (HP:0004540)	3.17699967
13	Methylmalonic acidemia (HP:0002912)	3.02769547
14	Cerebral edema (HP:0002181)	3.00947682
15	Congenital stationary night blindness (HP:0007642)	2.98884089
16	Pancreatic cysts (HP:0001737)	2.88260321
17	Renal Fanconi syndrome (HP:0001994)	2.87675396
18	Methylmalonic aciduria (HP:0012120)	2.86015133
19	Abolished electroretinogram (ERG) (HP:0000550)	2.81629447
20	IgG deficiency (HP:0004315)	2.78158115
21	Increased serum lactate (HP:0002151)	2.76161741
22	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.72642156
23	Abnormality of urine glucose concentration (HP:0011016)	2.68490238
24	Glycosuria (HP:0003076)	2.68490238
25	Renal cortical cysts (HP:0000803)	2.68392663
26	Optic disc pallor (HP:0000543)	2.67401810
27	Lactic acidosis (HP:0003128)	2.66636512
28	Reticulocytopenia (HP:0001896)	2.63183098
29	Abnormality of the renal cortex (HP:0011035)	2.62772723
30	Hyperglycinemia (HP:0002154)	2.58681714
31	Increased intramyocellular lipid droplets (HP:0012240)	2.56398486
32	Exertional dyspnea (HP:0002875)	2.54485308
33	Abnormal number of erythroid precursors (HP:0012131)	2.52597328
34	Lethargy (HP:0001254)	2.50904002
35	Abnormality of cells of the erythroid lineage (HP:0012130)	2.50809272
36	Abnormal rod and cone electroretinograms (HP:0008323)	2.48378988
37	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.47307696
38	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.46448760
39	Abnormality of vitamin B metabolism (HP:0004340)	2.40167435
40	Abnormality of serine family amino acid metabolism (HP:0010894)	2.38213059
41	Abnormality of glycine metabolism (HP:0010895)	2.38213059
42	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.38017581
43	Hyperglycinuria (HP:0003108)	2.37418096
44	True hermaphroditism (HP:0010459)	2.34941259
45	Macrocytic anemia (HP:0001972)	2.33701309
46	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.33320378
47	Pancreatic fibrosis (HP:0100732)	2.30668125
48	Elevated erythrocyte sedimentation rate (HP:0003565)	2.30344278
49	Type II lissencephaly (HP:0007260)	2.26575387
50	Nephronophthisis (HP:0000090)	2.24207296
51	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.24102847
52	Dicarboxylic aciduria (HP:0003215)	2.23747505
53	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.23747505
54	Respiratory failure (HP:0002878)	2.22514931
55	Molar tooth sign on MRI (HP:0002419)	2.22395188
56	Abnormality of midbrain morphology (HP:0002418)	2.22395188
57	Aplasia/hypoplasia of the uterus (HP:0008684)	2.20508893
58	Abnormality of the pons (HP:0007361)	2.17849894
59	Increased muscle lipid content (HP:0009058)	2.17199378
60	Type I transferrin isoform profile (HP:0003642)	2.12680339
61	Abnormality of serum amino acid levels (HP:0003112)	2.10912715
62	Hypoplasia of the pons (HP:0012110)	2.10410633
63	Hypoproteinemia (HP:0003075)	2.09930241
64	Colon cancer (HP:0003003)	2.07097251
65	Attenuation of retinal blood vessels (HP:0007843)	2.06953572
66	Pendular nystagmus (HP:0012043)	2.06507089
67	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.05315334
68	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.05315334
69	Abnormality of the renal medulla (HP:0100957)	2.04757106
70	Hyperphosphaturia (HP:0003109)	2.01986498
71	Delayed CNS myelination (HP:0002188)	2.00112749
72	Medial flaring of the eyebrow (HP:0010747)	1.99341343
73	Leukodystrophy (HP:0002415)	1.98923795
74	Hypothermia (HP:0002045)	1.96682182
75	Stomatitis (HP:0010280)	1.96516987
76	Abnormality of glutamine family amino acid metabolism (HP:0010902)	1.94378470
77	Abnormality of the prostate (HP:0008775)	1.92273322
78	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.91825309
79	Respiratory difficulties (HP:0002880)	1.90722762
80	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.90222241
81	Abnormality of alanine metabolism (HP:0010916)	1.90222241
82	Hyperalaninemia (HP:0003348)	1.90222241
83	Constricted visual fields (HP:0001133)	1.90095655
84	Abnormality of B cell number (HP:0010975)	1.87369020
85	Hypoplasia of the uterus (HP:0000013)	1.86785656
86	Pancytopenia (HP:0001876)	1.84812670
87	Bile duct proliferation (HP:0001408)	1.84244630
88	Abnormal biliary tract physiology (HP:0012439)	1.84244630
89	Severe combined immunodeficiency (HP:0004430)	1.82790647
90	Abnormality of renal resorption (HP:0011038)	1.81661958
91	Absent thumb (HP:0009777)	1.80178640
92	Exercise intolerance (HP:0003546)	1.79128617
93	Metabolic acidosis (HP:0001942)	1.78921984
94	Abnormal protein glycosylation (HP:0012346)	1.78285158
95	Abnormal glycosylation (HP:0012345)	1.78285158
96	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.78285158
97	Abnormal protein N-linked glycosylation (HP:0012347)	1.78285158
98	Decreased central vision (HP:0007663)	1.76948084
99	Tongue fasciculations (HP:0001308)	1.76717211
100	Thyroiditis (HP:0100646)	1.70955209

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	3.53611024
2	ZAK	3.47192189
3	TLK1	3.43999979
4	MAP4K2	3.39803170
5	NUAK1	2.79012023
6	TXK	2.48604268
7	TAOK3	2.47099647
8	ADRBK2	2.45184521
9	VRK1	2.35372857
10	CDK19	2.08308407
11	PASK	1.99279738
12	GRK1	1.99044204
13	FRK	1.93037912
14	BUB1	1.89141413
15	STK16	1.89024490
16	MST4	1.87205485
17	BCKDK	1.77804875
18	EIF2AK3	1.73844088
19	WNK3	1.58525137
20	WNK4	1.56009469
21	TAF1	1.55006443
22	BMPR1B	1.54028256
23	PINK1	1.52829349
24	MAP3K12	1.45963269
25	TSSK6	1.38034630
26	SRPK1	1.34193395
27	NEK1	1.29906852
28	TIE1	1.26230847
29	OXSR1	1.23318960
30	INSRR	1.21843833
31	ACVR1B	1.18683264
32	KIT	1.13644718
33	PBK	1.12813139
34	DYRK2	1.12424482
35	TRIM28	1.02762118
36	NME1	1.00274480
37	PLK3	0.99031541
38	IKBKB	0.94504888
39	CSNK1G3	0.93528074
40	KDR	0.93366057
41	RPS6KA5	0.91563205
42	TEC	0.89049319
43	MKNK1	0.88839748
44	STK39	0.88561227
45	MAP4K1	0.84720393
46	TESK2	0.82237739
47	TGFBR1	0.80438507
48	MAPK13	0.79918587
49	PHKG1	0.79692348
50	PHKG2	0.79692348
51	FES	0.78338445
52	MAP3K4	0.78032267
53	NME2	0.77301906
54	CSNK1G2	0.76757441
55	ITK	0.75407764
56	CSNK1G1	0.75118214
57	ERBB3	0.69338109
58	IKBKE	0.68869184
59	MAP2K7	0.66856130
60	MYLK	0.65872367
61	GRK6	0.65249825
62	BMPR2	0.65027519
63	MAP2K6	0.63116635
64	EIF2AK2	0.59401456
65	MUSK	0.58415845
66	DAPK1	0.58140496
67	CAMKK2	0.58042186
68	CSNK1A1L	0.57314646
69	CDC7	0.53954053
70	TNIK	0.53415153
71	ADRBK1	0.53155388
72	LIMK1	0.51665782
73	PRKCE	0.50561389
74	AURKB	0.48617956
75	CSF1R	0.48465270
76	PLK4	0.48216532
77	PRKCQ	0.47827395
78	LYN	0.47382682
79	CSNK2A2	0.47379707
80	CSNK2A1	0.47304862
81	CSNK1A1	0.46773725
82	SYK	0.45622578
83	MAP2K2	0.45024117
84	EIF2AK1	0.44817973
85	BCR	0.44437235
86	DAPK3	0.43889450
87	PRKCG	0.43162696
88	MKNK2	0.42643492
89	LCK	0.40882982
90	ATR	0.40740950
91	PDK2	0.40528960
92	EPHB2	0.39924755
93	FLT3	0.38818381
94	PLK1	0.38396007
95	WEE1	0.38229798
96	PRKCA	0.37169522
97	IGF1R	0.37072516
98	AURKA	0.36470444
99	EPHA4	0.35793154
100	PRKACA	0.34974456

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	3.54815790
2	Proteasome_Homo sapiens_hsa03050	3.39264258
3	Asthma_Homo sapiens_hsa05310	3.22197252
4	Oxidative phosphorylation_Homo sapiens_hsa00190	3.19097753
5	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.60372724
6	Parkinsons disease_Homo sapiens_hsa05012	2.57232579
7	Allograft rejection_Homo sapiens_hsa05330	2.49948102
8	Protein export_Homo sapiens_hsa03060	2.41500111
9	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.30030350
10	Graft-versus-host disease_Homo sapiens_hsa05332	2.08062135
11	Type I diabetes mellitus_Homo sapiens_hsa04940	2.07471418
12	RNA polymerase_Homo sapiens_hsa03020	2.07175730
13	Linoleic acid metabolism_Homo sapiens_hsa00591	1.77986998
14	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.71459091
15	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.67865621
16	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.66364919
17	Fat digestion and absorption_Homo sapiens_hsa04975	1.64828688
18	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.64643741
19	Caffeine metabolism_Homo sapiens_hsa00232	1.62757801
20	Alzheimers disease_Homo sapiens_hsa05010	1.62425094
21	Huntingtons disease_Homo sapiens_hsa05016	1.58543918
22	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.57892447
23	RNA degradation_Homo sapiens_hsa03018	1.51001324
24	Antigen processing and presentation_Homo sapiens_hsa04612	1.46747864
25	Sulfur metabolism_Homo sapiens_hsa00920	1.43972010
26	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.40051157
27	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.38282373
28	Primary immunodeficiency_Homo sapiens_hsa05340	1.31515513
29	Phototransduction_Homo sapiens_hsa04744	1.29082600
30	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.28277439
31	Nitrogen metabolism_Homo sapiens_hsa00910	1.25406375
32	Propanoate metabolism_Homo sapiens_hsa00640	1.24365615
33	Homologous recombination_Homo sapiens_hsa03440	1.23486311
34	Basal transcription factors_Homo sapiens_hsa03022	1.23284884
35	Mismatch repair_Homo sapiens_hsa03430	1.20547341
36	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.18724212
37	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.17080031
38	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.16461210
39	Tryptophan metabolism_Homo sapiens_hsa00380	1.15813637
40	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.14247954
41	Pyrimidine metabolism_Homo sapiens_hsa00240	1.13717963
42	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.10869029
43	Spliceosome_Homo sapiens_hsa03040	1.10112221
44	Cardiac muscle contraction_Homo sapiens_hsa04260	1.08053204
45	Peroxisome_Homo sapiens_hsa04146	1.07050022
46	One carbon pool by folate_Homo sapiens_hsa00670	1.05214240
47	Fanconi anemia pathway_Homo sapiens_hsa03460	1.03505176
48	Rheumatoid arthritis_Homo sapiens_hsa05323	1.03444283
49	Glutathione metabolism_Homo sapiens_hsa00480	1.01005229
50	Chemical carcinogenesis_Homo sapiens_hsa05204	0.97896584
51	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.96980024
52	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.96143909
53	Purine metabolism_Homo sapiens_hsa00230	0.95330104
54	RNA transport_Homo sapiens_hsa03013	0.94487511
55	Ether lipid metabolism_Homo sapiens_hsa00565	0.93713298
56	Base excision repair_Homo sapiens_hsa03410	0.92587116
57	DNA replication_Homo sapiens_hsa03030	0.91581192
58	Nucleotide excision repair_Homo sapiens_hsa03420	0.90632689
59	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.88024796
60	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.86757207
61	Butanoate metabolism_Homo sapiens_hsa00650	0.80336596
62	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.80106948
63	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.79691538
64	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.78602533
65	Retinol metabolism_Homo sapiens_hsa00830	0.74383905
66	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.74130821
67	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.74049643
68	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.73092563
69	Non-homologous end-joining_Homo sapiens_hsa03450	0.72093922
70	Fatty acid elongation_Homo sapiens_hsa00062	0.68882985
71	Metabolic pathways_Homo sapiens_hsa01100	0.66901702
72	Selenocompound metabolism_Homo sapiens_hsa00450	0.63090782
73	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.62769810
74	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.61727083
75	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.61616461
76	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.58926243
77	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.56917012
78	Viral myocarditis_Homo sapiens_hsa05416	0.54327394
79	Sulfur relay system_Homo sapiens_hsa04122	0.54021195
80	Regulation of autophagy_Homo sapiens_hsa04140	0.53690220
81	Arginine biosynthesis_Homo sapiens_hsa00220	0.52597878
82	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.51926299
83	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.49378817
84	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.45836574
85	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.45636007
86	Mineral absorption_Homo sapiens_hsa04978	0.45418370
87	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.45110305
88	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.42837854
89	Pyruvate metabolism_Homo sapiens_hsa00620	0.42519318
90	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.42281453
91	Folate biosynthesis_Homo sapiens_hsa00790	0.42095343
92	Renin-angiotensin system_Homo sapiens_hsa04614	0.37003830
93	Arginine and proline metabolism_Homo sapiens_hsa00330	0.36938603
94	Fatty acid degradation_Homo sapiens_hsa00071	0.36307810
95	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.34555372
96	Collecting duct acid secretion_Homo sapiens_hsa04966	0.33941040
97	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.28784451
98	Glycerolipid metabolism_Homo sapiens_hsa00561	0.28249578
99	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.27125325
100	Olfactory transduction_Homo sapiens_hsa04740	0.27047507

EEF1A1P12

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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