ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	6.06730839
2	cytidine deamination (GO:0009972)	4.65884916
3	cytidine metabolic process (GO:0046087)	4.65884916
4	cytidine catabolic process (GO:0006216)	4.65884916
5	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.60134299
6	ribosomal small subunit assembly (GO:0000028)	4.39087603
7	ATP synthesis coupled proton transport (GO:0015986)	4.15775529
8	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.15775529
9	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.03911405
10	pyrimidine ribonucleoside catabolic process (GO:0046133)	4.03629222
11	proteasome assembly (GO:0043248)	3.93003922
12	water-soluble vitamin biosynthetic process (GO:0042364)	3.85881142
13	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.68418427
14	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.68418427
15	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.35959465
16	platelet dense granule organization (GO:0060155)	3.31677644
17	protein complex biogenesis (GO:0070271)	3.31603361
18	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.23358358
19	protein neddylation (GO:0045116)	3.15753964
20	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.15186569
21	regulation of cellular amino acid metabolic process (GO:0006521)	3.09093886
22	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.07938266
23	respiratory chain complex IV assembly (GO:0008535)	3.06445625
24	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.04505203
25	NADH dehydrogenase complex assembly (GO:0010257)	3.04505203
26	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.04505203
27	positive regulation of defense response to virus by host (GO:0002230)	3.04277441
28	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.03894359
29	positive regulation of prostaglandin secretion (GO:0032308)	3.03296157
30	termination of RNA polymerase III transcription (GO:0006386)	3.01784730
31	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.01784730
32	mitochondrial respiratory chain complex assembly (GO:0033108)	2.99987492
33	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.92965304
34	respiratory electron transport chain (GO:0022904)	2.88166020
35	electron transport chain (GO:0022900)	2.88006876
36	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.85947797
37	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.85947797
38	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.85947797
39	pseudouridine synthesis (GO:0001522)	2.85391214
40	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.84577282
41	mannosylation (GO:0097502)	2.82769897
42	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.80800339
43	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.80800339
44	GPI anchor metabolic process (GO:0006505)	2.80314946
45	cytochrome complex assembly (GO:0017004)	2.79656531
46	metallo-sulfur cluster assembly (GO:0031163)	2.78679834
47	iron-sulfur cluster assembly (GO:0016226)	2.78679834
48	rRNA modification (GO:0000154)	2.74432508
49	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.72980906
50	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.72980906
51	ribosomal large subunit biogenesis (GO:0042273)	2.72746155
52	response to pheromone (GO:0019236)	2.72725821
53	L-fucose catabolic process (GO:0042355)	2.72705366
54	fucose catabolic process (GO:0019317)	2.72705366
55	L-fucose metabolic process (GO:0042354)	2.72705366
56	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.72414472
57	regulation of regulatory T cell differentiation (GO:0045589)	2.71561665
58	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.71403045
59	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.71171421
60	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.69769034
61	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.68928527
62	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.68812264
63	negative regulation of ligase activity (GO:0051352)	2.68812264
64	protein deneddylation (GO:0000338)	2.67412459
65	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.66378645
66	piRNA metabolic process (GO:0034587)	2.65761268
67	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.64540066
68	isotype switching (GO:0045190)	2.64540066
69	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.64540066
70	GPI anchor biosynthetic process (GO:0006506)	2.64198131
71	negative regulation of telomere maintenance (GO:0032205)	2.64097255
72	regulation of chronic inflammatory response (GO:0002676)	2.63831542
73	negative regulation of mast cell activation (GO:0033004)	2.63363813
74	cullin deneddylation (GO:0010388)	2.62987672
75	behavioral response to nicotine (GO:0035095)	2.60372457
76	cellular response to interleukin-15 (GO:0071350)	2.57583112
77	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.57477698
78	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	2.54592522
79	DNA demethylation (GO:0080111)	2.54197080
80	Arp2/3 complex-mediated actin nucleation (GO:0034314)	2.53493611
81	regulation of T cell receptor signaling pathway (GO:0050856)	2.53034336
82	tRNA processing (GO:0008033)	2.51754565
83	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.50674292
84	base-excision repair, AP site formation (GO:0006285)	2.50070534
85	peptidyl-histidine modification (GO:0018202)	2.48097505
86	preassembly of GPI anchor in ER membrane (GO:0016254)	2.47036803
87	sequestering of actin monomers (GO:0042989)	2.46600544
88	actin nucleation (GO:0045010)	2.45597731
89	GTP biosynthetic process (GO:0006183)	2.44815529
90	regulation of T cell mediated cytotoxicity (GO:0001914)	2.43990347
91	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.43159678
92	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.43148136
93	translation (GO:0006412)	2.43038997
94	regulation of activation of Janus kinase activity (GO:0010533)	2.41029224
95	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	2.39880370
96	maturation of SSU-rRNA (GO:0030490)	2.39427089
97	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.39182254
98	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.37792777
99	chaperone-mediated protein transport (GO:0072321)	2.37042513
100	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.36387570

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.07152595
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.06932196
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.76916462
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.37856571
5	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.30181639
6	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.17771305
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.00463274
8	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.91623839
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.91163595
10	VDR_23849224_ChIP-Seq_CD4+_Human	2.75639316
11	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.75229031
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.74693362
13	VDR_22108803_ChIP-Seq_LS180_Human	2.72387400
14	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.51745800
15	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.46142441
16	ELK1_19687146_ChIP-ChIP_HELA_Human	2.31259706
17	IGF1R_20145208_ChIP-Seq_DFB_Human	2.27480760
18	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.26073728
19	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.23765832
20	FOXP3_21729870_ChIP-Seq_TREG_Human	2.22429334
21	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.16964485
22	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.11534566
23	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.08941026
24	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.01757418
25	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.00362416
26	MYC_18940864_ChIP-ChIP_HL60_Human	1.96085157
27	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.94044697
28	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.91263304
29	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.82801606
30	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.68359370
31	IRF1_19129219_ChIP-ChIP_H3396_Human	1.66871014
32	EWS_26573619_Chip-Seq_HEK293_Human	1.63823011
33	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.62656652
34	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.62593229
35	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.56300010
36	TP53_22573176_ChIP-Seq_HFKS_Human	1.50668951
37	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.49529067
38	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.43725259
39	GATA3_26560356_Chip-Seq_TH2_Human	1.37899189
40	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.36666314
41	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.36666314
42	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.36319804
43	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.36120810
44	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.35855321
45	MYB_26560356_Chip-Seq_TH2_Human	1.35448321
46	FUS_26573619_Chip-Seq_HEK293_Human	1.35383036
47	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.32778287
48	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.32715122
49	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.32576303
50	AR_20517297_ChIP-Seq_VCAP_Human	1.31348466
51	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.29428617
52	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.28874762
53	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.25827442
54	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.22573836
55	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.21534823
56	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.17670651
57	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.16459677
58	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.16241853
59	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.14516810
60	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.14116280
61	P300_19829295_ChIP-Seq_ESCs_Human	1.13493137
62	ER_23166858_ChIP-Seq_MCF-7_Human	1.12743722
63	NCOR_22424771_ChIP-Seq_293T_Human	1.12258793
64	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.11772606
65	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.11639514
66	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.11371741
67	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.10738976
68	NANOG_19829295_ChIP-Seq_ESCs_Human	1.10363959
69	SOX2_19829295_ChIP-Seq_ESCs_Human	1.10363959
70	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.10229456
71	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.09701470
72	GABP_19822575_ChIP-Seq_HepG2_Human	1.08950036
73	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.08891764
74	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.08129310
75	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.07920059
76	DCP1A_22483619_ChIP-Seq_HELA_Human	1.07596099
77	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.05304698
78	CBP_20019798_ChIP-Seq_JUKART_Human	1.05304698
79	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.05220170
80	TTF2_22483619_ChIP-Seq_HELA_Human	1.04429581
81	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.01036701
82	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.00673033
83	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.00290489
84	TAF15_26573619_Chip-Seq_HEK293_Human	0.99900739
85	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.99315888
86	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.99223179
87	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.99124655
88	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.99018641
89	NANOG_20526341_ChIP-Seq_ESCs_Human	0.98897518
90	GATA3_27048872_Chip-Seq_THYMUS_Human	0.97512031
91	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.97157925
92	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.95783957
93	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.95171605
94	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.94665363
95	ERG_20517297_ChIP-Seq_VCAP_Human	0.93571780
96	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.93517460
97	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.92648278
98	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.92575369
99	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.91555355
100	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.90402210

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	4.01829587
2	MP0001835_abnormal_antigen_presentation	2.85846705
3	MP0002102_abnormal_ear_morphology	2.69235524
4	MP0008877_abnormal_DNA_methylation	2.58239493
5	MP0002163_abnormal_gland_morphology	2.47586271
6	MP0006072_abnormal_retinal_apoptosis	2.44241032
7	MP0004147_increased_porphyrin_level	2.26210436
8	MP0002138_abnormal_hepatobiliary_system	2.21906511
9	MP0005084_abnormal_gallbladder_morpholo	2.20728031
10	MP0009785_altered_susceptibility_to	2.18235325
11	MP0008872_abnormal_physiological_respon	2.11777153
12	MP0005645_abnormal_hypothalamus_physiol	2.07843523
13	MP0003763_abnormal_thymus_physiology	1.98451749
14	MP0002148_abnormal_hypersensitivity_rea	1.97845529
15	MP0008058_abnormal_DNA_repair	1.85882181
16	MP0005075_abnormal_melanosome_morpholog	1.85476283
17	MP0003195_calcinosis	1.85239354
18	MP0000372_irregular_coat_pigmentation	1.83210349
19	MP0003786_premature_aging	1.81668363
20	MP0001800_abnormal_humoral_immune	1.81430875
21	MP0006292_abnormal_olfactory_placode	1.81378179
22	MP0005379_endocrine/exocrine_gland_phen	1.80555823
23	MP0005000_abnormal_immune_tolerance	1.80214428
24	MP0000685_abnormal_immune_system	1.79203003
25	MP0009333_abnormal_splenocyte_physiolog	1.74945138
26	MP0002837_dystrophic_cardiac_calcinosis	1.72591910
27	MP0008875_abnormal_xenobiotic_pharmacok	1.69167686
28	MP0001873_stomach_inflammation	1.68782423
29	MP0002166_altered_tumor_susceptibility	1.65407463
30	MP0003806_abnormal_nucleotide_metabolis	1.63461231
31	MP0002006_tumorigenesis	1.56011597
32	MP0002723_abnormal_immune_serum	1.54741977
33	MP0001790_abnormal_immune_system	1.52429064
34	MP0005387_immune_system_phenotype	1.52429064
35	MP0005551_abnormal_eye_electrophysiolog	1.46239878
36	MP0003011_delayed_dark_adaptation	1.46143208
37	MP0002420_abnormal_adaptive_immunity	1.43498409
38	MP0001819_abnormal_immune_cell	1.42225825
39	MP0002736_abnormal_nociception_after	1.41981701
40	MP0002876_abnormal_thyroid_physiology	1.41101981
41	MP0005253_abnormal_eye_physiology	1.39051810
42	MP0001986_abnormal_taste_sensitivity	1.37727151
43	MP0001764_abnormal_homeostasis	1.35437004
44	MP0002452_abnormal_antigen_presenting	1.34598877
45	MP0003724_increased_susceptibility_to	1.34537760
46	MP0001919_abnormal_reproductive_system	1.32973172
47	MP0005389_reproductive_system_phenotype	1.30738748
48	MP0001968_abnormal_touch/_nociception	1.27964075
49	MP0004885_abnormal_endolymph	1.27165219
50	MP0010155_abnormal_intestine_physiology	1.26604452
51	MP0003252_abnormal_bile_duct	1.26503402
52	MP0003718_maternal_effect	1.24472597
53	MP0008995_early_reproductive_senescence	1.23335340
54	MP0003866_abnormal_defecation	1.23197652
55	MP0003646_muscle_fatigue	1.21955348
56	MP0005025_abnormal_response_to	1.21347396
57	MP0006036_abnormal_mitochondrial_physio	1.16986012
58	MP0002277_abnormal_respiratory_mucosa	1.14884646
59	MP0001845_abnormal_inflammatory_respons	1.12961499
60	MP0000689_abnormal_spleen_morphology	1.12238494
61	MP0005360_urolithiasis	1.11311758
62	MP0005646_abnormal_pituitary_gland	1.10261718
63	MP0001984_abnormal_olfaction	1.10142361
64	MP0002398_abnormal_bone_marrow	1.09406234
65	MP0005410_abnormal_fertilization	1.08983822
66	MP0009379_abnormal_foot_pigmentation	1.08356853
67	MP0009764_decreased_sensitivity_to	1.08089794
68	MP0000716_abnormal_immune_system	1.06794728
69	MP0004142_abnormal_muscle_tone	1.05670761
70	MP0004145_abnormal_muscle_electrophysio	1.04818614
71	MP0001529_abnormal_vocalization	1.04242103
72	MP0001905_abnormal_dopamine_level	1.03386722
73	MP0002405_respiratory_system_inflammati	1.02023578
74	MP0005377_hearing/vestibular/ear_phenot	1.01211406
75	MP0003878_abnormal_ear_physiology	1.01211406
76	MP0005332_abnormal_amino_acid	0.98649488
77	MP0002722_abnormal_immune_system	0.96893152
78	MP0005085_abnormal_gallbladder_physiolo	0.94530430
79	MP0003693_abnormal_embryo_hatching	0.93888845
80	MP0002693_abnormal_pancreas_physiology	0.93686848
81	MP0005636_abnormal_mineral_homeostasis	0.91725822
82	MP0000703_abnormal_thymus_morphology	0.86166542
83	MP0001119_abnormal_female_reproductive	0.84700629
84	MP0002429_abnormal_blood_cell	0.84520481
85	MP0002254_reproductive_system_inflammat	0.83751589
86	MP0003186_abnormal_redox_activity	0.83685672
87	MP0008469_abnormal_protein_level	0.83214330
88	MP0002638_abnormal_pupillary_reflex	0.83097714
89	MP0006035_abnormal_mitochondrial_morpho	0.82649678
90	MP0003787_abnormal_imprinting	0.79594291
91	MP0010386_abnormal_urinary_bladder	0.78449520
92	MP0001501_abnormal_sleep_pattern	0.77344745
93	MP0003567_abnormal_fetal_cardiomyocyte	0.76733811
94	MP0002160_abnormal_reproductive_system	0.76379406
95	MP0006082_CNS_inflammation	0.76271110
96	MP0006276_abnormal_autonomic_nervous	0.76194079
97	MP0001929_abnormal_gametogenesis	0.75263551
98	MP0002938_white_spotting	0.74162355
99	MP0008789_abnormal_olfactory_epithelium	0.72522626
100	MP0001485_abnormal_pinna_reflex	0.71668543

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	3.78328074
2	Mitochondrial inheritance (HP:0001427)	3.73633266
3	IgG deficiency (HP:0004315)	3.68502221
4	Increased CSF lactate (HP:0002490)	3.41377322
5	Abnormal mitochondria in muscle tissue (HP:0008316)	3.38126572
6	Increased hepatocellular lipid droplets (HP:0006565)	3.33998265
7	Acute encephalopathy (HP:0006846)	3.30353092
8	Lipid accumulation in hepatocytes (HP:0006561)	3.23055269
9	Progressive macrocephaly (HP:0004481)	3.20577811
10	Hepatocellular necrosis (HP:0001404)	3.13408664
11	Congenital stationary night blindness (HP:0007642)	3.11224179
12	3-Methylglutaconic aciduria (HP:0003535)	3.07965623
13	Methylmalonic acidemia (HP:0002912)	3.06809179
14	Hepatic necrosis (HP:0002605)	3.05473455
15	Pancreatic cysts (HP:0001737)	3.00908637
16	Renal cortical cysts (HP:0000803)	2.99858423
17	Severe combined immunodeficiency (HP:0004430)	2.98504930
18	Abolished electroretinogram (ERG) (HP:0000550)	2.83829831
19	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.79709918
20	Abnormality of B cell number (HP:0010975)	2.79439642
21	Abnormality of the renal cortex (HP:0011035)	2.77625406
22	Aplastic anemia (HP:0001915)	2.76963063
23	Renal Fanconi syndrome (HP:0001994)	2.76429300
24	Methylmalonic aciduria (HP:0012120)	2.72327022
25	True hermaphroditism (HP:0010459)	2.71383485
26	Thyroiditis (HP:0100646)	2.69435312
27	Hypoproteinemia (HP:0003075)	2.69248927
28	Cerebral edema (HP:0002181)	2.61959827
29	Increased intramyocellular lipid droplets (HP:0012240)	2.56853281
30	Abnormal rod and cone electroretinograms (HP:0008323)	2.56686198
31	Pancreatic fibrosis (HP:0100732)	2.53988063
32	Increased serum lactate (HP:0002151)	2.53746171
33	Stomatitis (HP:0010280)	2.51743985
34	Abnormality of T cell number (HP:0011839)	2.50336207
35	Elevated erythrocyte sedimentation rate (HP:0003565)	2.49111305
36	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.48556107
37	T lymphocytopenia (HP:0005403)	2.39575222
38	Type I transferrin isoform profile (HP:0003642)	2.39041284
39	Abnormality of the prostate (HP:0008775)	2.37514226
40	Molar tooth sign on MRI (HP:0002419)	2.37271913
41	Abnormality of midbrain morphology (HP:0002418)	2.37271913
42	B lymphocytopenia (HP:0010976)	2.34228636
43	Optic disc pallor (HP:0000543)	2.33915965
44	Abnormality of T cells (HP:0002843)	2.32909077
45	Abnormality of urine glucose concentration (HP:0011016)	2.32888092
46	Glycosuria (HP:0003076)	2.32888092
47	Lactic acidosis (HP:0003128)	2.32713287
48	Attenuation of retinal blood vessels (HP:0007843)	2.32021996
49	Increased IgM level (HP:0003496)	2.30643500
50	Combined immunodeficiency (HP:0005387)	2.29446880
51	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.28307144
52	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.28307144
53	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.28069447
54	Hyperglycinemia (HP:0002154)	2.27656140
55	Exertional dyspnea (HP:0002875)	2.24940965
56	Nephronophthisis (HP:0000090)	2.22761676
57	Lethargy (HP:0001254)	2.22355199
58	Aplasia/hypoplasia of the uterus (HP:0008684)	2.20562229
59	Increased muscle lipid content (HP:0009058)	2.19576850
60	Abnormal glycosylation (HP:0012345)	2.18654953
61	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.18654953
62	Abnormal protein N-linked glycosylation (HP:0012347)	2.18654953
63	Abnormal protein glycosylation (HP:0012346)	2.18654953
64	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.18083290
65	Dicarboxylic aciduria (HP:0003215)	2.18083290
66	Abnormality of eosinophils (HP:0001879)	2.16786815
67	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.14615697
68	Abnormality of vitamin B metabolism (HP:0004340)	2.11000370
69	Generalized aminoaciduria (HP:0002909)	2.10797911
70	Type 2 muscle fiber atrophy (HP:0003554)	2.09841379
71	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.08220840
72	Pendular nystagmus (HP:0012043)	2.07549851
73	Pancytopenia (HP:0001876)	2.07370202
74	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.07071094
75	Constricted visual fields (HP:0001133)	2.06435572
76	Medial flaring of the eyebrow (HP:0010747)	2.03411335
77	Abnormal number of erythroid precursors (HP:0012131)	2.02269083
78	Colon cancer (HP:0003003)	2.01631807
79	Decreased central vision (HP:0007663)	1.98870346
80	Abnormality of T cell physiology (HP:0011840)	1.98086063
81	Hypoplasia of the uterus (HP:0000013)	1.96844457
82	Autoimmune hemolytic anemia (HP:0001890)	1.96670132
83	Abnormality of the renal medulla (HP:0100957)	1.94839335
84	Reduced antithrombin III activity (HP:0001976)	1.93718666
85	Abnormality of serine family amino acid metabolism (HP:0010894)	1.93266685
86	Abnormality of glycine metabolism (HP:0010895)	1.93266685
87	Congenital, generalized hypertrichosis (HP:0004540)	1.92909321
88	Respiratory failure (HP:0002878)	1.92546314
89	Chronic diarrhea (HP:0002028)	1.91975028
90	Abnormality of the pons (HP:0007361)	1.90514300
91	Hypothermia (HP:0002045)	1.84927145
92	Hyperalaninemia (HP:0003348)	1.84125638
93	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.84125638
94	Abnormality of alanine metabolism (HP:0010916)	1.84125638
95	Hypoplasia of the pons (HP:0012110)	1.82784939
96	Type II lissencephaly (HP:0007260)	1.81697916
97	Abnormality of serum amino acid levels (HP:0003112)	1.81537053
98	Abnormality of cells of the erythroid lineage (HP:0012130)	1.80649957
99	Hypoalbuminemia (HP:0003073)	1.79506304
100	Abnormal albumin level (HP:0012116)	1.79506304

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ZAK	4.18778946
2	TXK	4.01741002
3	TLK1	3.67180271
4	MAP4K2	3.09351422
5	VRK2	2.81096188
6	TAOK3	2.52656001
7	NUAK1	2.42865201
8	BCKDK	2.39176969
9	VRK1	2.36291102
10	ADRBK2	2.34001403
11	KDR	2.25640053
12	MST4	2.25373198
13	GRK1	2.06184552
14	BUB1	2.00985133
15	FRK	1.93321880
16	CDK19	1.88113647
17	PASK	1.79725131
18	EIF2AK3	1.75567750
19	TESK2	1.75358588
20	MAP4K1	1.64285125
21	WNK3	1.53570296
22	TRIM28	1.38764971
23	ITK	1.26766917
24	BMPR1B	1.24725383
25	STK16	1.22688164
26	GRK6	1.17067655
27	MAP3K12	1.14716869
28	TEC	1.13546624
29	IKBKB	1.11986146
30	KIT	1.11694660
31	PINK1	1.09057789
32	OXSR1	1.06785287
33	MAP3K4	1.01716666
34	LIMK1	1.00781342
35	TIE1	1.00099128
36	FES	0.99790392
37	CSNK1G3	0.92647810
38	INSRR	0.92248530
39	SYK	0.91113362
40	RPS6KA5	0.89285143
41	MUSK	0.89203153
42	SRPK1	0.88903067
43	WNK4	0.88729703
44	PRKCQ	0.88361757
45	ACVR1B	0.84398604
46	PLK3	0.83853576
47	DYRK2	0.81662684
48	DAPK1	0.80165363
49	CSNK1G1	0.78765990
50	MAP2K7	0.78144820
51	TSSK6	0.77706681
52	ERBB3	0.75261427
53	NEK1	0.74899586
54	MKNK1	0.74650896
55	TAF1	0.72173264
56	CSNK1G2	0.72172276
57	IKBKE	0.71717962
58	RPS6KA4	0.68569562
59	PBK	0.67397467
60	SCYL2	0.64505284
61	BMPR2	0.64402990
62	LCK	0.63703400
63	EIF2AK2	0.61268461
64	LYN	0.61186370
65	CSNK1A1L	0.60668925
66	CSF1R	0.59729386
67	TNIK	0.58065416
68	STK39	0.57852597
69	PLK4	0.57648172
70	GRK7	0.56914990
71	BTK	0.56554647
72	BCR	0.55908855
73	MATK	0.54894651
74	FLT3	0.54661866
75	MAPK13	0.52476741
76	NME1	0.51771274
77	PIM1	0.51479598
78	MYLK	0.51308457
79	PRKCE	0.51260182
80	ADRBK1	0.49005807
81	PLK2	0.48245225
82	MAP2K6	0.46822547
83	MAP2K2	0.46325310
84	ATR	0.45852499
85	MAPKAPK5	0.45672255
86	DAPK2	0.45275183
87	IGF1R	0.44078113
88	CDK8	0.43380476
89	CAMKK2	0.43241066
90	MAP3K14	0.42283659
91	MAPKAPK3	0.40990416
92	GRK5	0.40165402
93	PLK1	0.39709712
94	TGFBR1	0.38778210
95	DAPK3	0.38114622
96	CSNK2A1	0.37070665
97	MKNK2	0.36770643
98	TBK1	0.35682706
99	AURKA	0.35021888
100	CSNK2A2	0.33865276

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.76573957
2	Oxidative phosphorylation_Homo sapiens_hsa00190	2.96074919
3	Primary immunodeficiency_Homo sapiens_hsa05340	2.93136659
4	Ribosome_Homo sapiens_hsa03010	2.55041707
5	Protein export_Homo sapiens_hsa03060	2.49800993
6	Allograft rejection_Homo sapiens_hsa05330	2.49645150
7	Parkinsons disease_Homo sapiens_hsa05012	2.41980762
8	Asthma_Homo sapiens_hsa05310	2.41375529
9	RNA polymerase_Homo sapiens_hsa03020	2.35439241
10	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.34399471
11	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.32949008
12	Graft-versus-host disease_Homo sapiens_hsa05332	2.28654953
13	Type I diabetes mellitus_Homo sapiens_hsa04940	2.23113947
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.95906232
15	Antigen processing and presentation_Homo sapiens_hsa04612	1.78587999
16	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.77863018
17	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.72403282
18	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.72120564
19	RNA degradation_Homo sapiens_hsa03018	1.49393340
20	Phototransduction_Homo sapiens_hsa04744	1.49259990
21	Homologous recombination_Homo sapiens_hsa03440	1.46386360
22	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.42234261
23	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.41682725
24	Huntingtons disease_Homo sapiens_hsa05016	1.40493293
25	Alzheimers disease_Homo sapiens_hsa05010	1.39850887
26	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.38751299
27	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.37626776
28	Linoleic acid metabolism_Homo sapiens_hsa00591	1.35921176
29	Propanoate metabolism_Homo sapiens_hsa00640	1.35020595
30	Mismatch repair_Homo sapiens_hsa03430	1.30191295
31	Pyrimidine metabolism_Homo sapiens_hsa00240	1.29247728
32	Basal transcription factors_Homo sapiens_hsa03022	1.29129022
33	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.28207887
34	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.26794897
35	One carbon pool by folate_Homo sapiens_hsa00670	1.26169887
36	Sulfur metabolism_Homo sapiens_hsa00920	1.22761631
37	Rheumatoid arthritis_Homo sapiens_hsa05323	1.22146021
38	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.18926099
39	Butanoate metabolism_Homo sapiens_hsa00650	1.17466006
40	Fanconi anemia pathway_Homo sapiens_hsa03460	1.17322625
41	Spliceosome_Homo sapiens_hsa03040	1.13570033
42	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.08989831
43	Nitrogen metabolism_Homo sapiens_hsa00910	1.06854919
44	DNA replication_Homo sapiens_hsa03030	1.06726611
45	Peroxisome_Homo sapiens_hsa04146	1.06152549
46	Purine metabolism_Homo sapiens_hsa00230	1.05329144
47	Selenocompound metabolism_Homo sapiens_hsa00450	1.05198160
48	Nucleotide excision repair_Homo sapiens_hsa03420	1.05134352
49	RNA transport_Homo sapiens_hsa03013	0.99012315
50	Caffeine metabolism_Homo sapiens_hsa00232	0.96244397
51	Tryptophan metabolism_Homo sapiens_hsa00380	0.95953321
52	Base excision repair_Homo sapiens_hsa03410	0.95854531
53	Non-homologous end-joining_Homo sapiens_hsa03450	0.91434687
54	Cardiac muscle contraction_Homo sapiens_hsa04260	0.87217530
55	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.86617879
56	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.85572984
57	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.80653373
58	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.80627701
59	Fatty acid elongation_Homo sapiens_hsa00062	0.80066700
60	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.79930735
61	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.79729617
62	Fat digestion and absorption_Homo sapiens_hsa04975	0.78550567
63	Chemical carcinogenesis_Homo sapiens_hsa05204	0.76875488
64	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.76186760
65	Ether lipid metabolism_Homo sapiens_hsa00565	0.75950078
66	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.71553595
67	Retinol metabolism_Homo sapiens_hsa00830	0.69963415
68	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.69099295
69	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.68547858
70	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.68462597
71	Regulation of autophagy_Homo sapiens_hsa04140	0.67368623
72	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.66361547
73	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.65958992
74	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.65885382
75	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.65058416
76	Viral myocarditis_Homo sapiens_hsa05416	0.64546893
77	Metabolic pathways_Homo sapiens_hsa01100	0.62032915
78	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.61906499
79	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.60443522
80	Glutathione metabolism_Homo sapiens_hsa00480	0.60331841
81	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.59479134
82	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.59046444
83	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.57847089
84	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.56283186
85	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.53813534
86	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.49623550
87	Collecting duct acid secretion_Homo sapiens_hsa04966	0.49296387
88	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.47960984
89	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.46698810
90	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.45490499
91	Herpes simplex infection_Homo sapiens_hsa05168	0.44372573
92	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.41689363
93	Olfactory transduction_Homo sapiens_hsa04740	0.39763205
94	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.38870012
95	Pyruvate metabolism_Homo sapiens_hsa00620	0.38056572
96	Steroid biosynthesis_Homo sapiens_hsa00100	0.36244538
97	Alcoholism_Homo sapiens_hsa05034	0.35729769
98	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.32795507
99	Measles_Homo sapiens_hsa05162	0.31465035
100	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.31393249

EEF1A1P13

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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