EEF1A1P14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.57880755
2cytidine metabolic process (GO:0046087)5.46928608
3cytidine catabolic process (GO:0006216)5.46928608
4cytidine deamination (GO:0009972)5.46928608
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.95084011
6pyrimidine ribonucleoside catabolic process (GO:0046133)4.72382585
7ribosomal small subunit assembly (GO:0000028)3.94492362
8regulation of regulatory T cell differentiation (GO:0045589)3.71116129
9positive regulation of defense response to virus by host (GO:0002230)3.49406520
10positive thymic T cell selection (GO:0045059)3.48837435
11positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.35778772
12ATP synthesis coupled proton transport (GO:0015986)3.35570338
13energy coupled proton transport, down electrochemical gradient (GO:0015985)3.35570338
14positive regulation of T cell mediated cytotoxicity (GO:0001916)3.29306527
15mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.27422750
16water-soluble vitamin biosynthetic process (GO:0042364)3.22199281
17antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.22138782
18positive T cell selection (GO:0043368)3.19419528
19Arp2/3 complex-mediated actin nucleation (GO:0034314)3.19351009
20positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.16820163
21cellular response to interleukin-15 (GO:0071350)3.15435210
22actin nucleation (GO:0045010)3.14050335
23regulation of B cell receptor signaling pathway (GO:0050855)3.04638609
24positive regulation of alpha-beta T cell proliferation (GO:0046641)3.03043665
25regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.02632713
26response to pheromone (GO:0019236)3.02620485
27negative T cell selection (GO:0043383)2.99877757
28RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.96685689
29tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.96685689
30regulation of T cell mediated cytotoxicity (GO:0001914)2.92014331
31proteasome assembly (GO:0043248)2.87408793
32regulation of isotype switching to IgG isotypes (GO:0048302)2.86108522
33positive regulation of prostaglandin secretion (GO:0032308)2.85610962
34regulation of T cell receptor signaling pathway (GO:0050856)2.83511230
35regulation of leukocyte mediated cytotoxicity (GO:0001910)2.82481463
36regulation of cellular amino acid metabolic process (GO:0006521)2.82295514
37positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.80617036
38positive regulation of natural killer cell mediated immunity (GO:0002717)2.80575765
39regulation of alpha-beta T cell proliferation (GO:0046640)2.80382518
40positive regulation of cell killing (GO:0031343)2.79673156
41response to interferon-beta (GO:0035456)2.79655524
42mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.77751065
43platelet dense granule organization (GO:0060155)2.77584235
44mannosylation (GO:0097502)2.74054858
45protein complex biogenesis (GO:0070271)2.73256346
46positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.72775775
47regulation of chronic inflammatory response (GO:0002676)2.72408517
48nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.71168682
49regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.69271176
50negative thymic T cell selection (GO:0045060)2.69073443
51DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.68406746
52negative regulation of T cell apoptotic process (GO:0070233)2.67335974
53transcription elongation from RNA polymerase III promoter (GO:0006385)2.66124740
54termination of RNA polymerase III transcription (GO:0006386)2.66124740
55mast cell activation (GO:0045576)2.65813885
56negative regulation of mast cell activation (GO:0033004)2.64859086
57exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.64069766
58negative regulation by host of viral transcription (GO:0043922)2.63404210
59cytochrome complex assembly (GO:0017004)2.61946564
60positive regulation of calcium-mediated signaling (GO:0050850)2.61804448
61respiratory chain complex IV assembly (GO:0008535)2.60720094
62signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.60375693
63signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.60375693
64signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.60375693
65regulation of activation of Janus kinase activity (GO:0010533)2.57310732
66intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.57120835
67signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.57120835
68fucose catabolic process (GO:0019317)2.56794239
69L-fucose metabolic process (GO:0042354)2.56794239
70L-fucose catabolic process (GO:0042355)2.56794239
71regulation of cell killing (GO:0031341)2.54675222
72regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.53122121
73regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.52954535
74regulation of natural killer cell mediated immunity (GO:0002715)2.52954535
75pyrimidine nucleoside catabolic process (GO:0046135)2.52835018
76electron transport chain (GO:0022900)2.52126444
77T cell receptor signaling pathway (GO:0050852)2.51644258
78piRNA metabolic process (GO:0034587)2.51133581
79respiratory electron transport chain (GO:0022904)2.50945423
80metallo-sulfur cluster assembly (GO:0031163)2.50570691
81iron-sulfur cluster assembly (GO:0016226)2.50570691
82leukocyte aggregation (GO:0070486)2.50022104
83lymphocyte costimulation (GO:0031294)2.49897982
84T cell costimulation (GO:0031295)2.49290994
85pseudouridine synthesis (GO:0001522)2.47901738
86RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.46069146
87antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.45577640
88rRNA modification (GO:0000154)2.45442366
89signal transduction involved in DNA integrity checkpoint (GO:0072401)2.45307541
90signal transduction involved in DNA damage checkpoint (GO:0072422)2.45307541
91negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.44582186
92immunoglobulin mediated immune response (GO:0016064)2.43794091
93signal transduction involved in cell cycle checkpoint (GO:0072395)2.43769899
94mitochondrial respiratory chain complex assembly (GO:0033108)2.43084319
95mitochondrial respiratory chain complex I assembly (GO:0032981)2.42282976
96NADH dehydrogenase complex assembly (GO:0010257)2.42282976
97mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.42282976
98protein neddylation (GO:0045116)2.40464430
99sulfation (GO:0051923)2.39265640
100response to interleukin-15 (GO:0070672)2.38359382

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.95249397
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.83692615
3ELF1_17652178_ChIP-ChIP_JURKAT_Human3.73840309
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.52819521
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.47796670
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.37217083
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.36570061
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.26622047
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.12154508
10VDR_22108803_ChIP-Seq_LS180_Human2.68504004
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.60507549
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.57796810
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.34410324
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.33375799
15VDR_23849224_ChIP-Seq_CD4+_Human2.33011474
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.31952870
17ZNF274_21170338_ChIP-Seq_K562_Hela2.28791020
18IRF8_21731497_ChIP-ChIP_J774_Mouse2.21696094
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.12276235
20FLI1_27457419_Chip-Seq_LIVER_Mouse2.09902646
21FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.07196557
22MYB_26560356_Chip-Seq_TH2_Human1.95983259
23NOTCH1_21737748_ChIP-Seq_TLL_Human1.92946298
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.90314607
25ETS1_20019798_ChIP-Seq_JURKAT_Human1.86456282
26FOXP3_21729870_ChIP-Seq_TREG_Human1.85169226
27SRF_21415370_ChIP-Seq_HL-1_Mouse1.74309390
28ELK1_19687146_ChIP-ChIP_HELA_Human1.70827073
29GATA3_26560356_Chip-Seq_TH2_Human1.68586393
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.67941340
31EGR1_23403033_ChIP-Seq_LIVER_Mouse1.65188628
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.63532702
33LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.63334081
34IGF1R_20145208_ChIP-Seq_DFB_Human1.60651679
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.60020310
36RUNX_20019798_ChIP-Seq_JUKART_Human1.55855756
37MYC_18940864_ChIP-ChIP_HL60_Human1.54489605
38FOXA1_27270436_Chip-Seq_PROSTATE_Human1.54306260
39FOXA1_25329375_ChIP-Seq_VCAP_Human1.54306260
40AR_20517297_ChIP-Seq_VCAP_Human1.52318287
41TP53_22573176_ChIP-Seq_HFKS_Human1.47623320
42EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.46591657
43SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.45926658
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.40599537
45EWS_26573619_Chip-Seq_HEK293_Human1.40290846
46GATA3_27048872_Chip-Seq_THYMUS_Human1.37723077
47STAT4_19710469_ChIP-ChIP_TH1__Mouse1.28349869
48FOXA1_21572438_ChIP-Seq_LNCaP_Human1.27780058
49PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.27620764
50TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.20561316
51NANOG_20526341_ChIP-Seq_ESCs_Human1.20558345
52PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.20383435
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.19712263
54NCOR_22424771_ChIP-Seq_293T_Human1.19168915
55NANOG_19829295_ChIP-Seq_ESCs_Human1.18773384
56SOX2_19829295_ChIP-Seq_ESCs_Human1.18773384
57AUTS2_25519132_ChIP-Seq_293T-REX_Human1.18172868
58RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.16916254
59NFE2_27457419_Chip-Seq_LIVER_Mouse1.16441289
60PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.15774967
61GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.14353325
62ER_23166858_ChIP-Seq_MCF-7_Human1.12243026
63MYB_26560356_Chip-Seq_TH1_Human1.12193053
64TAF2_19829295_ChIP-Seq_ESCs_Human1.11638088
65PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10673781
66HOXB4_20404135_ChIP-ChIP_EML_Mouse1.10423522
67CREB1_15753290_ChIP-ChIP_HEK293T_Human1.10194283
68FUS_26573619_Chip-Seq_HEK293_Human1.09280716
69ERG_20517297_ChIP-Seq_VCAP_Human1.07578656
70HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.07026925
71SUZ12_27294783_Chip-Seq_NPCs_Mouse1.06321511
72POU3F2_20337985_ChIP-ChIP_501MEL_Human1.05483726
73IRF1_19129219_ChIP-ChIP_H3396_Human1.05404735
74GATA3_21878914_ChIP-Seq_MCF-7_Human1.04464759
75CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.03492883
76CIITA_25753668_ChIP-Seq_RAJI_Human1.02377583
77CTBP1_25329375_ChIP-Seq_LNCAP_Human1.02025592
78GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01490651
79RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.01424760
80CBP_20019798_ChIP-Seq_JUKART_Human1.01151782
81IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.01151782
82SPI1_23547873_ChIP-Seq_NB4_Human1.00889390
83GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.00200980
84MYC_19829295_ChIP-Seq_ESCs_Human0.99455473
85CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.99311462
86EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.97983273
87GATA6_21074721_ChIP-Seq_CACO-2_Human0.97398164
88EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.96978617
89FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96680196
90ZFP57_27257070_Chip-Seq_ESCs_Mouse0.95774179
91CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.94787979
92EZH2_27294783_Chip-Seq_NPCs_Mouse0.94464608
93YY1_21170310_ChIP-Seq_MESCs_Mouse0.94343779
94GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94024226
95P300_19829295_ChIP-Seq_ESCs_Human0.93366778
96MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.93176113
97LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.92469133
98RBPJ_21746931_ChIP-Seq_IB4_Human0.92027053
99STAT1_20625510_ChIP-Seq_HELA_Human0.91868728
100GATA3_26560356_Chip-Seq_TH1_Human0.91796385

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.85568533
2MP0001835_abnormal_antigen_presentation3.44530830
3MP0004147_increased_porphyrin_level3.12963033
4MP0009785_altered_susceptibility_to2.62062043
5MP0005360_urolithiasis2.53665135
6MP0003763_abnormal_thymus_physiology2.39999937
7MP0000685_abnormal_immune_system2.36207229
8MP0002148_abnormal_hypersensitivity_rea2.34621847
9MP0002138_abnormal_hepatobiliary_system2.33301349
10MP0001873_stomach_inflammation2.30020124
11MP0001800_abnormal_humoral_immune2.29690380
12MP0005000_abnormal_immune_tolerance2.16612453
13MP0002166_altered_tumor_susceptibility2.15760106
14MP0003806_abnormal_nucleotide_metabolis2.05584418
15MP0005645_abnormal_hypothalamus_physiol2.02532296
16MP0002876_abnormal_thyroid_physiology2.01544618
17MP0010155_abnormal_intestine_physiology1.97397586
18MP0008872_abnormal_physiological_respon1.94254402
19MP0001790_abnormal_immune_system1.91431538
20MP0005387_immune_system_phenotype1.91431538
21MP0003866_abnormal_defecation1.90700577
22MP0009333_abnormal_splenocyte_physiolog1.89306805
23MP0002723_abnormal_immune_serum1.88678444
24MP0002420_abnormal_adaptive_immunity1.84441300
25MP0001819_abnormal_immune_cell1.81094887
26MP0002006_tumorigenesis1.78900591
27MP0005025_abnormal_response_to1.75162180
28MP0002102_abnormal_ear_morphology1.75051337
29MP0000372_irregular_coat_pigmentation1.73642184
30MP0008875_abnormal_xenobiotic_pharmacok1.72443086
31MP0005075_abnormal_melanosome_morpholog1.71111073
32MP0005084_abnormal_gallbladder_morpholo1.67210712
33MP0002452_abnormal_antigen_presenting1.66530216
34MP0006072_abnormal_retinal_apoptosis1.64867864
35MP0003724_increased_susceptibility_to1.62521079
36MP0009379_abnormal_foot_pigmentation1.61091419
37MP0003786_premature_aging1.42752744
38MP0000716_abnormal_immune_system1.40912411
39MP0001764_abnormal_homeostasis1.40817809
40MP0002398_abnormal_bone_marrow1.40197194
41MP0001986_abnormal_taste_sensitivity1.40056839
42MP0001845_abnormal_inflammatory_respons1.40035708
43MP0005085_abnormal_gallbladder_physiolo1.39478585
44MP0008877_abnormal_DNA_methylation1.37065207
45MP0005551_abnormal_eye_electrophysiolog1.34397886
46MP0006082_CNS_inflammation1.34190503
47MP0000689_abnormal_spleen_morphology1.31402187
48MP0008058_abnormal_DNA_repair1.28843711
49MP0000465_gastrointestinal_hemorrhage1.27483255
50MP0001666_abnormal_nutrient_absorption1.26324244
51MP0003436_decreased_susceptibility_to1.24683170
52MP0003195_calcinosis1.21377211
53MP0002163_abnormal_gland_morphology1.20772967
54MP0003252_abnormal_bile_duct1.20629114
55MP0003646_muscle_fatigue1.17685178
56MP0003718_maternal_effect1.16581916
57MP0002722_abnormal_immune_system1.16556010
58MP0004885_abnormal_endolymph1.16022220
59MP0008469_abnormal_protein_level1.13975947
60MP0002405_respiratory_system_inflammati1.13954858
61MP0005389_reproductive_system_phenotype1.12044975
62MP0001968_abnormal_touch/_nociception1.10610243
63MP0002429_abnormal_blood_cell1.10505842
64MP0005646_abnormal_pituitary_gland1.09964091
65MP0002736_abnormal_nociception_after1.08652026
66MP0002139_abnormal_hepatobiliary_system1.07934491
67MP0009764_decreased_sensitivity_to1.06817950
68MP0000703_abnormal_thymus_morphology1.05655532
69MP0006292_abnormal_olfactory_placode1.04080286
70MP0002419_abnormal_innate_immunity1.03286952
71MP0005332_abnormal_amino_acid1.03213710
72MP0001919_abnormal_reproductive_system1.02648946
73MP0005410_abnormal_fertilization1.01412499
74MP0002277_abnormal_respiratory_mucosa0.98808369
75MP0002933_joint_inflammation0.97985085
76MP0009643_abnormal_urine_homeostasis0.95325734
77MP0003878_abnormal_ear_physiology0.95177274
78MP0005377_hearing/vestibular/ear_phenot0.95177274
79MP0001501_abnormal_sleep_pattern0.93496009
80MP0002837_dystrophic_cardiac_calcinosis0.92736962
81MP0005636_abnormal_mineral_homeostasis0.91884381
82MP0002693_abnormal_pancreas_physiology0.91680458
83MP0005365_abnormal_bile_salt0.90207727
84MP0005253_abnormal_eye_physiology0.88632663
85MP0003011_delayed_dark_adaptation0.87723009
86MP0001905_abnormal_dopamine_level0.84342783
87MP0002160_abnormal_reproductive_system0.83161270
88MP0005379_endocrine/exocrine_gland_phen0.82077803
89MP0001664_abnormal_digestion0.81538334
90MP0006036_abnormal_mitochondrial_physio0.80909904
91MP0005166_decreased_susceptibility_to0.80740233
92MP0004145_abnormal_muscle_electrophysio0.80048648
93MP0000013_abnormal_adipose_tissue0.79090000
94MP0001188_hyperpigmentation0.78428213
95MP0001663_abnormal_digestive_system0.77783891
96MP0001765_abnormal_ion_homeostasis0.76951629
97MP0002019_abnormal_tumor_incidence0.73374469
98MP0001853_heart_inflammation0.73083450
99MP0002234_abnormal_pharynx_morphology0.72979826
100MP0010386_abnormal_urinary_bladder0.69715619

Predicted human phenotypes

RankGene SetZ-score
1IgG deficiency (HP:0004315)4.49988813
2Abolished electroretinogram (ERG) (HP:0000550)3.54791368
3Severe combined immunodeficiency (HP:0004430)3.51507496
4Decreased electroretinogram (ERG) amplitude (HP:0000654)3.46961233
5Elevated erythrocyte sedimentation rate (HP:0003565)3.46783030
6T lymphocytopenia (HP:0005403)3.35621968
7Abnormality of T cell number (HP:0011839)3.35589107
8Mitochondrial inheritance (HP:0001427)3.31912837
9Congenital stationary night blindness (HP:0007642)3.29354127
10Abnormality of B cell number (HP:0010975)3.28169779
11Acute necrotizing encephalopathy (HP:0006965)3.24748852
12Hypoproteinemia (HP:0003075)3.23984689
13Absent rod-and cone-mediated responses on ERG (HP:0007688)3.18344277
14Increased IgM level (HP:0003496)3.03266242
15Thyroiditis (HP:0100646)3.00938570
16Increased CSF lactate (HP:0002490)2.95196814
17Aplastic anemia (HP:0001915)2.94367173
18Type II lissencephaly (HP:0007260)2.93627488
19Abnormality of T cells (HP:0002843)2.92199594
20B lymphocytopenia (HP:0010976)2.89792872
21Abnormal mitochondria in muscle tissue (HP:0008316)2.89529872
22Increased hepatocellular lipid droplets (HP:0006565)2.87408595
23Lipid accumulation in hepatocytes (HP:0006561)2.87071409
24Hepatocellular necrosis (HP:0001404)2.86362380
25Acute encephalopathy (HP:0006846)2.85607287
26Progressive macrocephaly (HP:0004481)2.79746413
27Abnormal rod and cone electroretinograms (HP:0008323)2.79310447
28Hepatic necrosis (HP:0002605)2.76644785
29Abnormality of eosinophils (HP:0001879)2.75860999
30Chronic diarrhea (HP:0002028)2.73320322
31Hypoplasia of the pons (HP:0012110)2.71641811
32Abnormality of the prostate (HP:0008775)2.70791979
333-Methylglutaconic aciduria (HP:0003535)2.69465305
34Combined immunodeficiency (HP:0005387)2.68632863
35Stomatitis (HP:0010280)2.62485106
36Abnormality of the pons (HP:0007361)2.62358967
37Pancreatic cysts (HP:0001737)2.61174376
38Cerebral edema (HP:0002181)2.55722160
39Panhypogammaglobulinemia (HP:0003139)2.54755568
40Autoimmune hemolytic anemia (HP:0001890)2.52492185
41Attenuation of retinal blood vessels (HP:0007843)2.51412289
42Cerebellar dysplasia (HP:0007033)2.47930068
43Abnormality of the renal cortex (HP:0011035)2.42718454
44Renal cortical cysts (HP:0000803)2.42403862
45Eosinophilia (HP:0001880)2.40686377
46Increased intramyocellular lipid droplets (HP:0012240)2.39617191
47Renal Fanconi syndrome (HP:0001994)2.30997694
48Abnormal delayed hypersensitivity skin test (HP:0002963)2.30496722
49Agammaglobulinemia (HP:0004432)2.30384344
50Optic disc pallor (HP:0000543)2.29407029
51Abnormality of T cell physiology (HP:0011840)2.29224745
52Molar tooth sign on MRI (HP:0002419)2.28153207
53Abnormality of midbrain morphology (HP:0002418)2.28153207
54Lethargy (HP:0001254)2.22737369
55Methylmalonic acidemia (HP:0002912)2.21552047
56Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.20182761
57Dicarboxylic aciduria (HP:0003215)2.19133040
58Abnormality of dicarboxylic acid metabolism (HP:0010995)2.19133040
59Glycosuria (HP:0003076)2.17745317
60Abnormality of urine glucose concentration (HP:0011016)2.17745317
61Pancreatic fibrosis (HP:0100732)2.16501853
62Decreased central vision (HP:0007663)2.16295795
63Increased muscle lipid content (HP:0009058)2.15856886
64Abnormal albumin level (HP:0012116)2.14867711
65Hypoalbuminemia (HP:0003073)2.14867711
66True hermaphroditism (HP:0010459)2.12731503
67Increased serum lactate (HP:0002151)2.12138628
68Methylmalonic aciduria (HP:0012120)2.12110506
69Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.11957570
70Retinal dysplasia (HP:0007973)2.10908671
71Constricted visual fields (HP:0001133)2.10901085
72Pancytopenia (HP:0001876)2.08243898
73Lactic acidosis (HP:0003128)2.08194021
74Type I transferrin isoform profile (HP:0003642)2.06774198
75Encephalitis (HP:0002383)2.06341114
76Exertional dyspnea (HP:0002875)2.06110411
77Abnormality of the vitamin B12 metabolism (HP:0004341)2.04690253
78Abnormality of vitamin B metabolism (HP:0004340)2.00598258
79Prostate neoplasm (HP:0100787)1.96652407
80Recurrent bronchitis (HP:0002837)1.94127522
81Reduced antithrombin III activity (HP:0001976)1.92714071
82Abnormal glycosylation (HP:0012345)1.92374242
83Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.92374242
84Abnormal protein N-linked glycosylation (HP:0012347)1.92374242
85Abnormal protein glycosylation (HP:0012346)1.92374242
86Nephronophthisis (HP:0000090)1.90252060
87Ketosis (HP:0001946)1.88529553
88Autoimmune thrombocytopenia (HP:0001973)1.86100230
89Abnormality of aspartate family amino acid metabolism (HP:0010899)1.85943762
90Granulocytopenia (HP:0001913)1.85604904
91Decreased activity of mitochondrial respiratory chain (HP:0008972)1.83375545
92Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.83375545
93IgM deficiency (HP:0002850)1.82825545
94Congenital, generalized hypertrichosis (HP:0004540)1.82669671
95Recurrent cutaneous fungal infections (HP:0011370)1.81808881
96Chronic mucocutaneous candidiasis (HP:0002728)1.81808881
97Abnormality of glycine metabolism (HP:0010895)1.80609095
98Abnormality of serine family amino acid metabolism (HP:0010894)1.80609095
99Respiratory failure (HP:0002878)1.79632611
100Leukocytosis (HP:0001974)1.78217417

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.77951626
2ZAK3.14725069
3TAOK33.08991806
4BCKDK2.84627555
5TLK12.83987470
6KDR2.81208824
7VRK22.73937027
8NUAK12.52894759
9MAP4K22.34509335
10MAP4K12.29123222
11FRK2.23811664
12GRK12.20638674
13TESK22.19926141
14ADRBK22.18863618
15EIF2AK32.01065672
16VRK11.98735138
17MST41.98687571
18CDK191.90782736
19KIT1.73129855
20ITK1.60044632
21PASK1.55517476
22TEC1.51318331
23FES1.47507547
24ACVR1B1.40934313
25SYK1.27404809
26MAP3K121.27318480
27GRK61.26580758
28TIE11.19934501
29IKBKB1.19756546
30BMPR1B1.19363140
31MAPKAPK31.14992892
32MARK31.06066055
33DAPK11.04029837
34INSRR1.00212788
35PINK11.00156031
36PRKCQ0.98518336
37BUB10.98517171
38TRIM280.98392630
39OXSR10.97147261
40WNK30.96092757
41TAF10.94068932
42SCYL20.93458155
43NLK0.93081494
44LCK0.89885333
45CSF1R0.89158723
46STK160.87546366
47FLT30.86310978
48PIM10.86074113
49STK100.84572216
50MATK0.82948353
51LYN0.81137847
52IKBKE0.79832076
53BMPR20.79504960
54NME10.79265312
55RPS6KA50.78320368
56WNK40.77419557
57MYLK0.76248344
58MAP2K60.75032556
59BTK0.72142310
60STK390.70064888
61GRK70.66013926
62MUSK0.64602181
63PBK0.64021246
64JAK30.62263326
65ZAP700.59477201
66TRPM70.59173503
67MAPKAPK50.58053517
68TNK20.57142240
69EIF2AK20.54037214
70MAP2K20.53614193
71IGF1R0.53398894
72CDK80.51968151
73PLK30.50112202
74DAPK20.48153184
75GRK50.47602591
76TBK10.46364360
77CSNK1G10.46275556
78ADRBK10.45269014
79PIK3CG0.44182427
80CSK0.43232733
81CAMKK20.42145356
82TGFBR10.41555655
83RPS6KA40.41529798
84CSNK1G30.41208489
85DYRK20.39169738
86BRSK20.39081671
87PRKCA0.38936718
88DAPK30.37284172
89ERBB30.37165673
90PRKCE0.34528126
91PRKG20.33586164
92TSSK60.33255135
93CSNK2A10.31849840
94PRKCD0.30409181
95OBSCN0.30002724
96CSNK2A20.29072784
97HCK0.28899884
98MAPK130.28175510
99ATR0.27985459
100PRKACA0.26440451

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.69021588
2Allograft rejection_Homo sapiens_hsa053303.28738176
3Proteasome_Homo sapiens_hsa030503.28218064
4Asthma_Homo sapiens_hsa053103.22173417
5Autoimmune thyroid disease_Homo sapiens_hsa053203.11434954
6Graft-versus-host disease_Homo sapiens_hsa053323.09497981
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.95725141
8Type I diabetes mellitus_Homo sapiens_hsa049402.74590667
9Antigen processing and presentation_Homo sapiens_hsa046122.45678271
10Oxidative phosphorylation_Homo sapiens_hsa001902.32548483
11Ribosome_Homo sapiens_hsa030102.18933695
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.89648227
13RNA polymerase_Homo sapiens_hsa030201.85164068
14Parkinsons disease_Homo sapiens_hsa050121.81868343
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.77638662
16Hematopoietic cell lineage_Homo sapiens_hsa046401.76194770
17Linoleic acid metabolism_Homo sapiens_hsa005911.70916771
18Protein export_Homo sapiens_hsa030601.67261931
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.56159001
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.52004829
21Rheumatoid arthritis_Homo sapiens_hsa053231.46630247
22Phototransduction_Homo sapiens_hsa047441.46305969
23Maturity onset diabetes of the young_Homo sapiens_hsa049501.37953800
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.35023615
25Homologous recombination_Homo sapiens_hsa034401.30058855
26Caffeine metabolism_Homo sapiens_hsa002321.27633437
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.26853539
28Sulfur metabolism_Homo sapiens_hsa009201.25111170
29Fat digestion and absorption_Homo sapiens_hsa049751.23055310
30Systemic lupus erythematosus_Homo sapiens_hsa053221.22578798
31Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.15965887
32Nitrogen metabolism_Homo sapiens_hsa009101.13977068
33NF-kappa B signaling pathway_Homo sapiens_hsa040641.10456297
34RNA degradation_Homo sapiens_hsa030181.10291889
35Propanoate metabolism_Homo sapiens_hsa006401.09554253
36Peroxisome_Homo sapiens_hsa041461.05412658
37Tryptophan metabolism_Homo sapiens_hsa003801.05032234
38Alzheimers disease_Homo sapiens_hsa050101.03452982
39Viral myocarditis_Homo sapiens_hsa054160.99982989
40Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.99689493
41Huntingtons disease_Homo sapiens_hsa050160.99549148
42Chemical carcinogenesis_Homo sapiens_hsa052040.98872007
43Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.97272404
44Pyrimidine metabolism_Homo sapiens_hsa002400.96712160
45Butanoate metabolism_Homo sapiens_hsa006500.95112179
46One carbon pool by folate_Homo sapiens_hsa006700.93996350
47Arachidonic acid metabolism_Homo sapiens_hsa005900.93982204
48Staphylococcus aureus infection_Homo sapiens_hsa051500.90084174
49Ether lipid metabolism_Homo sapiens_hsa005650.89420677
50Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.88968113
51Fanconi anemia pathway_Homo sapiens_hsa034600.88503671
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.87434969
53Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.87387824
54Retinol metabolism_Homo sapiens_hsa008300.86613507
55T cell receptor signaling pathway_Homo sapiens_hsa046600.85819152
56Vitamin digestion and absorption_Homo sapiens_hsa049770.85436327
57Mismatch repair_Homo sapiens_hsa034300.84290177
58SNARE interactions in vesicular transport_Homo sapiens_hsa041300.81190070
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.81084353
60Purine metabolism_Homo sapiens_hsa002300.79587630
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.78740606
62Basal transcription factors_Homo sapiens_hsa030220.78385261
63NOD-like receptor signaling pathway_Homo sapiens_hsa046210.76116857
64Leishmaniasis_Homo sapiens_hsa051400.76105163
65DNA replication_Homo sapiens_hsa030300.74815318
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.70856762
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70162335
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.69054342
69Cardiac muscle contraction_Homo sapiens_hsa042600.68939505
70Nucleotide excision repair_Homo sapiens_hsa034200.67397730
71Pentose and glucuronate interconversions_Homo sapiens_hsa000400.64657891
72Cyanoamino acid metabolism_Homo sapiens_hsa004600.64502779
73Herpes simplex infection_Homo sapiens_hsa051680.63727272
74Base excision repair_Homo sapiens_hsa034100.62121392
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.61365862
76Primary bile acid biosynthesis_Homo sapiens_hsa001200.61097843
77Cysteine and methionine metabolism_Homo sapiens_hsa002700.59448905
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58104031
79Selenocompound metabolism_Homo sapiens_hsa004500.55887643
80Fatty acid degradation_Homo sapiens_hsa000710.50598391
81Regulation of autophagy_Homo sapiens_hsa041400.49844974
82Olfactory transduction_Homo sapiens_hsa047400.48882907
83Mineral absorption_Homo sapiens_hsa049780.48731349
84Non-homologous end-joining_Homo sapiens_hsa034500.47339143
85Glutathione metabolism_Homo sapiens_hsa004800.46869479
86Metabolic pathways_Homo sapiens_hsa011000.46690177
87Measles_Homo sapiens_hsa051620.45762167
88Spliceosome_Homo sapiens_hsa030400.44698669
89Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.40260728
90Fatty acid elongation_Homo sapiens_hsa000620.39315562
91RNA transport_Homo sapiens_hsa030130.39131350
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36793060
93Renin-angiotensin system_Homo sapiens_hsa046140.34224771
94RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.32678307
95Glycerolipid metabolism_Homo sapiens_hsa005610.31196143
96Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.29689664
97Epstein-Barr virus infection_Homo sapiens_hsa051690.27584984
98Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.27091259
99Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.26060563
100Sulfur relay system_Homo sapiens_hsa041220.23954840

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