ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	6.57880755
2	cytidine deamination (GO:0009972)	5.46928608
3	cytidine metabolic process (GO:0046087)	5.46928608
4	cytidine catabolic process (GO:0006216)	5.46928608
5	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.95084011
6	pyrimidine ribonucleoside catabolic process (GO:0046133)	4.72382585
7	ribosomal small subunit assembly (GO:0000028)	3.94492362
8	regulation of regulatory T cell differentiation (GO:0045589)	3.71116129
9	positive regulation of defense response to virus by host (GO:0002230)	3.49406520
10	positive thymic T cell selection (GO:0045059)	3.48837435
11	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	3.35778772
12	ATP synthesis coupled proton transport (GO:0015986)	3.35570338
13	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.35570338
14	positive regulation of T cell mediated cytotoxicity (GO:0001916)	3.29306527
15	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.27422750
16	water-soluble vitamin biosynthetic process (GO:0042364)	3.22199281
17	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	3.22138782
18	positive T cell selection (GO:0043368)	3.19419528
19	Arp2/3 complex-mediated actin nucleation (GO:0034314)	3.19351009
20	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	3.16820163
21	cellular response to interleukin-15 (GO:0071350)	3.15435210
22	actin nucleation (GO:0045010)	3.14050335
23	regulation of B cell receptor signaling pathway (GO:0050855)	3.04638609
24	positive regulation of alpha-beta T cell proliferation (GO:0046641)	3.03043665
25	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	3.02632713
26	response to pheromone (GO:0019236)	3.02620485
27	negative T cell selection (GO:0043383)	2.99877757
28	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.96685689
29	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.96685689
30	regulation of T cell mediated cytotoxicity (GO:0001914)	2.92014331
31	proteasome assembly (GO:0043248)	2.87408793
32	regulation of isotype switching to IgG isotypes (GO:0048302)	2.86108522
33	positive regulation of prostaglandin secretion (GO:0032308)	2.85610962
34	regulation of T cell receptor signaling pathway (GO:0050856)	2.83511230
35	regulation of leukocyte mediated cytotoxicity (GO:0001910)	2.82481463
36	regulation of cellular amino acid metabolic process (GO:0006521)	2.82295514
37	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	2.80617036
38	positive regulation of natural killer cell mediated immunity (GO:0002717)	2.80575765
39	regulation of alpha-beta T cell proliferation (GO:0046640)	2.80382518
40	positive regulation of cell killing (GO:0031343)	2.79673156
41	response to interferon-beta (GO:0035456)	2.79655524
42	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.77751065
43	platelet dense granule organization (GO:0060155)	2.77584235
44	mannosylation (GO:0097502)	2.74054858
45	protein complex biogenesis (GO:0070271)	2.73256346
46	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.72775775
47	regulation of chronic inflammatory response (GO:0002676)	2.72408517
48	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.71168682
49	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	2.69271176
50	negative thymic T cell selection (GO:0045060)	2.69073443
51	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.68406746
52	negative regulation of T cell apoptotic process (GO:0070233)	2.67335974
53	termination of RNA polymerase III transcription (GO:0006386)	2.66124740
54	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.66124740
55	mast cell activation (GO:0045576)	2.65813885
56	negative regulation of mast cell activation (GO:0033004)	2.64859086
57	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.64069766
58	negative regulation by host of viral transcription (GO:0043922)	2.63404210
59	cytochrome complex assembly (GO:0017004)	2.61946564
60	positive regulation of calcium-mediated signaling (GO:0050850)	2.61804448
61	respiratory chain complex IV assembly (GO:0008535)	2.60720094
62	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.60375693
63	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.60375693
64	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.60375693
65	regulation of activation of Janus kinase activity (GO:0010533)	2.57310732
66	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.57120835
67	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.57120835
68	L-fucose catabolic process (GO:0042355)	2.56794239
69	fucose catabolic process (GO:0019317)	2.56794239
70	L-fucose metabolic process (GO:0042354)	2.56794239
71	regulation of cell killing (GO:0031341)	2.54675222
72	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.53122121
73	regulation of natural killer cell mediated immunity (GO:0002715)	2.52954535
74	regulation of natural killer cell mediated cytotoxicity (GO:0042269)	2.52954535
75	pyrimidine nucleoside catabolic process (GO:0046135)	2.52835018
76	electron transport chain (GO:0022900)	2.52126444
77	T cell receptor signaling pathway (GO:0050852)	2.51644258
78	piRNA metabolic process (GO:0034587)	2.51133581
79	respiratory electron transport chain (GO:0022904)	2.50945423
80	metallo-sulfur cluster assembly (GO:0031163)	2.50570691
81	iron-sulfur cluster assembly (GO:0016226)	2.50570691
82	leukocyte aggregation (GO:0070486)	2.50022104
83	lymphocyte costimulation (GO:0031294)	2.49897982
84	T cell costimulation (GO:0031295)	2.49290994
85	pseudouridine synthesis (GO:0001522)	2.47901738
86	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.46069146
87	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.45577640
88	rRNA modification (GO:0000154)	2.45442366
89	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.45307541
90	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.45307541
91	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.44582186
92	immunoglobulin mediated immune response (GO:0016064)	2.43794091
93	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.43769899
94	mitochondrial respiratory chain complex assembly (GO:0033108)	2.43084319
95	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.42282976
96	NADH dehydrogenase complex assembly (GO:0010257)	2.42282976
97	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.42282976
98	protein neddylation (GO:0045116)	2.40464430
99	sulfation (GO:0051923)	2.39265640
100	response to interleukin-15 (GO:0070672)	2.38359382

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.95249397
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.83692615
3	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.73840309
4	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.52819521
5	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	3.47796670
6	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.37217083
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.36570061
8	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.26622047
9	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.12154508
10	VDR_22108803_ChIP-Seq_LS180_Human	2.68504004
11	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.60507549
12	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.57796810
13	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.34410324
14	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.33375799
15	VDR_23849224_ChIP-Seq_CD4+_Human	2.33011474
16	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.31952870
17	ZNF274_21170338_ChIP-Seq_K562_Hela	2.28791020
18	IRF8_21731497_ChIP-ChIP_J774_Mouse	2.21696094
19	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.12276235
20	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.09902646
21	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.07196557
22	MYB_26560356_Chip-Seq_TH2_Human	1.95983259
23	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.92946298
24	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.90314607
25	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.86456282
26	FOXP3_21729870_ChIP-Seq_TREG_Human	1.85169226
27	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.74309390
28	ELK1_19687146_ChIP-ChIP_HELA_Human	1.70827073
29	GATA3_26560356_Chip-Seq_TH2_Human	1.68586393
30	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.67941340
31	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.65188628
32	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.63532702
33	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.63334081
34	IGF1R_20145208_ChIP-Seq_DFB_Human	1.60651679
35	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.60020310
36	RUNX_20019798_ChIP-Seq_JUKART_Human	1.55855756
37	MYC_18940864_ChIP-ChIP_HL60_Human	1.54489605
38	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.54306260
39	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.54306260
40	AR_20517297_ChIP-Seq_VCAP_Human	1.52318287
41	TP53_22573176_ChIP-Seq_HFKS_Human	1.47623320
42	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.46591657
43	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.45926658
44	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.40599537
45	EWS_26573619_Chip-Seq_HEK293_Human	1.40290846
46	GATA3_27048872_Chip-Seq_THYMUS_Human	1.37723077
47	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.28349869
48	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.27780058
49	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.27620764
50	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.20561316
51	NANOG_20526341_ChIP-Seq_ESCs_Human	1.20558345
52	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.20383435
53	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.19712263
54	NCOR_22424771_ChIP-Seq_293T_Human	1.19168915
55	SOX2_19829295_ChIP-Seq_ESCs_Human	1.18773384
56	NANOG_19829295_ChIP-Seq_ESCs_Human	1.18773384
57	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.18172868
58	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.16916254
59	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.16441289
60	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.15774967
61	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.14353325
62	ER_23166858_ChIP-Seq_MCF-7_Human	1.12243026
63	MYB_26560356_Chip-Seq_TH1_Human	1.12193053
64	TAF2_19829295_ChIP-Seq_ESCs_Human	1.11638088
65	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.10673781
66	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.10423522
67	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.10194283
68	FUS_26573619_Chip-Seq_HEK293_Human	1.09280716
69	ERG_20517297_ChIP-Seq_VCAP_Human	1.07578656
70	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.07026925
71	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.06321511
72	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.05483726
73	IRF1_19129219_ChIP-ChIP_H3396_Human	1.05404735
74	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.04464759
75	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.03492883
76	CIITA_25753668_ChIP-Seq_RAJI_Human	1.02377583
77	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.02025592
78	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.01490651
79	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.01424760
80	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.01151782
81	CBP_20019798_ChIP-Seq_JUKART_Human	1.01151782
82	SPI1_23547873_ChIP-Seq_NB4_Human	1.00889390
83	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.00200980
84	MYC_19829295_ChIP-Seq_ESCs_Human	0.99455473
85	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.99311462
86	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.97983273
87	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.97398164
88	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.96978617
89	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.96680196
90	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.95774179
91	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.94787979
92	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.94464608
93	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.94343779
94	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.94024226
95	P300_19829295_ChIP-Seq_ESCs_Human	0.93366778
96	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.93176113
97	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	0.92469133
98	RBPJ_21746931_ChIP-Seq_IB4_Human	0.92027053
99	STAT1_20625510_ChIP-Seq_HELA_Human	0.91868728
100	GATA3_26560356_Chip-Seq_TH1_Human	0.91796385

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	4.85568533
2	MP0001835_abnormal_antigen_presentation	3.44530830
3	MP0004147_increased_porphyrin_level	3.12963033
4	MP0009785_altered_susceptibility_to	2.62062043
5	MP0005360_urolithiasis	2.53665135
6	MP0003763_abnormal_thymus_physiology	2.39999937
7	MP0000685_abnormal_immune_system	2.36207229
8	MP0002148_abnormal_hypersensitivity_rea	2.34621847
9	MP0002138_abnormal_hepatobiliary_system	2.33301349
10	MP0001873_stomach_inflammation	2.30020124
11	MP0001800_abnormal_humoral_immune	2.29690380
12	MP0005000_abnormal_immune_tolerance	2.16612453
13	MP0002166_altered_tumor_susceptibility	2.15760106
14	MP0003806_abnormal_nucleotide_metabolis	2.05584418
15	MP0005645_abnormal_hypothalamus_physiol	2.02532296
16	MP0002876_abnormal_thyroid_physiology	2.01544618
17	MP0010155_abnormal_intestine_physiology	1.97397586
18	MP0008872_abnormal_physiological_respon	1.94254402
19	MP0005387_immune_system_phenotype	1.91431538
20	MP0001790_abnormal_immune_system	1.91431538
21	MP0003866_abnormal_defecation	1.90700577
22	MP0009333_abnormal_splenocyte_physiolog	1.89306805
23	MP0002723_abnormal_immune_serum	1.88678444
24	MP0002420_abnormal_adaptive_immunity	1.84441300
25	MP0001819_abnormal_immune_cell	1.81094887
26	MP0002006_tumorigenesis	1.78900591
27	MP0005025_abnormal_response_to	1.75162180
28	MP0002102_abnormal_ear_morphology	1.75051337
29	MP0000372_irregular_coat_pigmentation	1.73642184
30	MP0008875_abnormal_xenobiotic_pharmacok	1.72443086
31	MP0005075_abnormal_melanosome_morpholog	1.71111073
32	MP0005084_abnormal_gallbladder_morpholo	1.67210712
33	MP0002452_abnormal_antigen_presenting	1.66530216
34	MP0006072_abnormal_retinal_apoptosis	1.64867864
35	MP0003724_increased_susceptibility_to	1.62521079
36	MP0009379_abnormal_foot_pigmentation	1.61091419
37	MP0003786_premature_aging	1.42752744
38	MP0000716_abnormal_immune_system	1.40912411
39	MP0001764_abnormal_homeostasis	1.40817809
40	MP0002398_abnormal_bone_marrow	1.40197194
41	MP0001986_abnormal_taste_sensitivity	1.40056839
42	MP0001845_abnormal_inflammatory_respons	1.40035708
43	MP0005085_abnormal_gallbladder_physiolo	1.39478585
44	MP0008877_abnormal_DNA_methylation	1.37065207
45	MP0005551_abnormal_eye_electrophysiolog	1.34397886
46	MP0006082_CNS_inflammation	1.34190503
47	MP0000689_abnormal_spleen_morphology	1.31402187
48	MP0008058_abnormal_DNA_repair	1.28843711
49	MP0000465_gastrointestinal_hemorrhage	1.27483255
50	MP0001666_abnormal_nutrient_absorption	1.26324244
51	MP0003436_decreased_susceptibility_to	1.24683170
52	MP0003195_calcinosis	1.21377211
53	MP0002163_abnormal_gland_morphology	1.20772967
54	MP0003252_abnormal_bile_duct	1.20629114
55	MP0003646_muscle_fatigue	1.17685178
56	MP0003718_maternal_effect	1.16581916
57	MP0002722_abnormal_immune_system	1.16556010
58	MP0004885_abnormal_endolymph	1.16022220
59	MP0008469_abnormal_protein_level	1.13975947
60	MP0002405_respiratory_system_inflammati	1.13954858
61	MP0005389_reproductive_system_phenotype	1.12044975
62	MP0001968_abnormal_touch/_nociception	1.10610243
63	MP0002429_abnormal_blood_cell	1.10505842
64	MP0005646_abnormal_pituitary_gland	1.09964091
65	MP0002736_abnormal_nociception_after	1.08652026
66	MP0002139_abnormal_hepatobiliary_system	1.07934491
67	MP0009764_decreased_sensitivity_to	1.06817950
68	MP0000703_abnormal_thymus_morphology	1.05655532
69	MP0006292_abnormal_olfactory_placode	1.04080286
70	MP0002419_abnormal_innate_immunity	1.03286952
71	MP0005332_abnormal_amino_acid	1.03213710
72	MP0001919_abnormal_reproductive_system	1.02648946
73	MP0005410_abnormal_fertilization	1.01412499
74	MP0002277_abnormal_respiratory_mucosa	0.98808369
75	MP0002933_joint_inflammation	0.97985085
76	MP0009643_abnormal_urine_homeostasis	0.95325734
77	MP0003878_abnormal_ear_physiology	0.95177274
78	MP0005377_hearing/vestibular/ear_phenot	0.95177274
79	MP0001501_abnormal_sleep_pattern	0.93496009
80	MP0002837_dystrophic_cardiac_calcinosis	0.92736962
81	MP0005636_abnormal_mineral_homeostasis	0.91884381
82	MP0002693_abnormal_pancreas_physiology	0.91680458
83	MP0005365_abnormal_bile_salt	0.90207727
84	MP0005253_abnormal_eye_physiology	0.88632663
85	MP0003011_delayed_dark_adaptation	0.87723009
86	MP0001905_abnormal_dopamine_level	0.84342783
87	MP0002160_abnormal_reproductive_system	0.83161270
88	MP0005379_endocrine/exocrine_gland_phen	0.82077803
89	MP0001664_abnormal_digestion	0.81538334
90	MP0006036_abnormal_mitochondrial_physio	0.80909904
91	MP0005166_decreased_susceptibility_to	0.80740233
92	MP0004145_abnormal_muscle_electrophysio	0.80048648
93	MP0000013_abnormal_adipose_tissue	0.79090000
94	MP0001188_hyperpigmentation	0.78428213
95	MP0001663_abnormal_digestive_system	0.77783891
96	MP0001765_abnormal_ion_homeostasis	0.76951629
97	MP0002019_abnormal_tumor_incidence	0.73374469
98	MP0001853_heart_inflammation	0.73083450
99	MP0002234_abnormal_pharynx_morphology	0.72979826
100	MP0010386_abnormal_urinary_bladder	0.69715619

Predicted human phenotypes

Rank	Gene Set	Z-score
1	IgG deficiency (HP:0004315)	4.49988813
2	Abolished electroretinogram (ERG) (HP:0000550)	3.54791368
3	Severe combined immunodeficiency (HP:0004430)	3.51507496
4	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.46961233
5	Elevated erythrocyte sedimentation rate (HP:0003565)	3.46783030
6	T lymphocytopenia (HP:0005403)	3.35621968
7	Abnormality of T cell number (HP:0011839)	3.35589107
8	Mitochondrial inheritance (HP:0001427)	3.31912837
9	Congenital stationary night blindness (HP:0007642)	3.29354127
10	Abnormality of B cell number (HP:0010975)	3.28169779
11	Acute necrotizing encephalopathy (HP:0006965)	3.24748852
12	Hypoproteinemia (HP:0003075)	3.23984689
13	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.18344277
14	Increased IgM level (HP:0003496)	3.03266242
15	Thyroiditis (HP:0100646)	3.00938570
16	Increased CSF lactate (HP:0002490)	2.95196814
17	Aplastic anemia (HP:0001915)	2.94367173
18	Type II lissencephaly (HP:0007260)	2.93627488
19	Abnormality of T cells (HP:0002843)	2.92199594
20	B lymphocytopenia (HP:0010976)	2.89792872
21	Abnormal mitochondria in muscle tissue (HP:0008316)	2.89529872
22	Increased hepatocellular lipid droplets (HP:0006565)	2.87408595
23	Lipid accumulation in hepatocytes (HP:0006561)	2.87071409
24	Hepatocellular necrosis (HP:0001404)	2.86362380
25	Acute encephalopathy (HP:0006846)	2.85607287
26	Progressive macrocephaly (HP:0004481)	2.79746413
27	Abnormal rod and cone electroretinograms (HP:0008323)	2.79310447
28	Hepatic necrosis (HP:0002605)	2.76644785
29	Abnormality of eosinophils (HP:0001879)	2.75860999
30	Chronic diarrhea (HP:0002028)	2.73320322
31	Hypoplasia of the pons (HP:0012110)	2.71641811
32	Abnormality of the prostate (HP:0008775)	2.70791979
33	3-Methylglutaconic aciduria (HP:0003535)	2.69465305
34	Combined immunodeficiency (HP:0005387)	2.68632863
35	Stomatitis (HP:0010280)	2.62485106
36	Abnormality of the pons (HP:0007361)	2.62358967
37	Pancreatic cysts (HP:0001737)	2.61174376
38	Cerebral edema (HP:0002181)	2.55722160
39	Panhypogammaglobulinemia (HP:0003139)	2.54755568
40	Autoimmune hemolytic anemia (HP:0001890)	2.52492185
41	Attenuation of retinal blood vessels (HP:0007843)	2.51412289
42	Cerebellar dysplasia (HP:0007033)	2.47930068
43	Abnormality of the renal cortex (HP:0011035)	2.42718454
44	Renal cortical cysts (HP:0000803)	2.42403862
45	Eosinophilia (HP:0001880)	2.40686377
46	Increased intramyocellular lipid droplets (HP:0012240)	2.39617191
47	Renal Fanconi syndrome (HP:0001994)	2.30997694
48	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.30496722
49	Agammaglobulinemia (HP:0004432)	2.30384344
50	Optic disc pallor (HP:0000543)	2.29407029
51	Abnormality of T cell physiology (HP:0011840)	2.29224745
52	Molar tooth sign on MRI (HP:0002419)	2.28153207
53	Abnormality of midbrain morphology (HP:0002418)	2.28153207
54	Lethargy (HP:0001254)	2.22737369
55	Methylmalonic acidemia (HP:0002912)	2.21552047
56	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.20182761
57	Dicarboxylic aciduria (HP:0003215)	2.19133040
58	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.19133040
59	Glycosuria (HP:0003076)	2.17745317
60	Abnormality of urine glucose concentration (HP:0011016)	2.17745317
61	Pancreatic fibrosis (HP:0100732)	2.16501853
62	Decreased central vision (HP:0007663)	2.16295795
63	Increased muscle lipid content (HP:0009058)	2.15856886
64	Hypoalbuminemia (HP:0003073)	2.14867711
65	Abnormal albumin level (HP:0012116)	2.14867711
66	True hermaphroditism (HP:0010459)	2.12731503
67	Increased serum lactate (HP:0002151)	2.12138628
68	Methylmalonic aciduria (HP:0012120)	2.12110506
69	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.11957570
70	Retinal dysplasia (HP:0007973)	2.10908671
71	Constricted visual fields (HP:0001133)	2.10901085
72	Pancytopenia (HP:0001876)	2.08243898
73	Lactic acidosis (HP:0003128)	2.08194021
74	Type I transferrin isoform profile (HP:0003642)	2.06774198
75	Encephalitis (HP:0002383)	2.06341114
76	Exertional dyspnea (HP:0002875)	2.06110411
77	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.04690253
78	Abnormality of vitamin B metabolism (HP:0004340)	2.00598258
79	Prostate neoplasm (HP:0100787)	1.96652407
80	Recurrent bronchitis (HP:0002837)	1.94127522
81	Reduced antithrombin III activity (HP:0001976)	1.92714071
82	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.92374242
83	Abnormal protein N-linked glycosylation (HP:0012347)	1.92374242
84	Abnormal protein glycosylation (HP:0012346)	1.92374242
85	Abnormal glycosylation (HP:0012345)	1.92374242
86	Nephronophthisis (HP:0000090)	1.90252060
87	Ketosis (HP:0001946)	1.88529553
88	Autoimmune thrombocytopenia (HP:0001973)	1.86100230
89	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.85943762
90	Granulocytopenia (HP:0001913)	1.85604904
91	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.83375545
92	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.83375545
93	IgM deficiency (HP:0002850)	1.82825545
94	Congenital, generalized hypertrichosis (HP:0004540)	1.82669671
95	Chronic mucocutaneous candidiasis (HP:0002728)	1.81808881
96	Recurrent cutaneous fungal infections (HP:0011370)	1.81808881
97	Abnormality of serine family amino acid metabolism (HP:0010894)	1.80609095
98	Abnormality of glycine metabolism (HP:0010895)	1.80609095
99	Respiratory failure (HP:0002878)	1.79632611
100	Leukocytosis (HP:0001974)	1.78217417

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	4.77951626
2	ZAK	3.14725069
3	TAOK3	3.08991806
4	BCKDK	2.84627555
5	TLK1	2.83987470
6	KDR	2.81208824
7	VRK2	2.73937027
8	NUAK1	2.52894759
9	MAP4K2	2.34509335
10	MAP4K1	2.29123222
11	FRK	2.23811664
12	GRK1	2.20638674
13	TESK2	2.19926141
14	ADRBK2	2.18863618
15	EIF2AK3	2.01065672
16	VRK1	1.98735138
17	MST4	1.98687571
18	CDK19	1.90782736
19	KIT	1.73129855
20	ITK	1.60044632
21	PASK	1.55517476
22	TEC	1.51318331
23	FES	1.47507547
24	ACVR1B	1.40934313
25	SYK	1.27404809
26	MAP3K12	1.27318480
27	GRK6	1.26580758
28	TIE1	1.19934501
29	IKBKB	1.19756546
30	BMPR1B	1.19363140
31	MAPKAPK3	1.14992892
32	MARK3	1.06066055
33	DAPK1	1.04029837
34	INSRR	1.00212788
35	PINK1	1.00156031
36	PRKCQ	0.98518336
37	BUB1	0.98517171
38	TRIM28	0.98392630
39	OXSR1	0.97147261
40	WNK3	0.96092757
41	TAF1	0.94068932
42	SCYL2	0.93458155
43	NLK	0.93081494
44	LCK	0.89885333
45	CSF1R	0.89158723
46	STK16	0.87546366
47	FLT3	0.86310978
48	PIM1	0.86074113
49	STK10	0.84572216
50	MATK	0.82948353
51	LYN	0.81137847
52	IKBKE	0.79832076
53	BMPR2	0.79504960
54	NME1	0.79265312
55	RPS6KA5	0.78320368
56	WNK4	0.77419557
57	MYLK	0.76248344
58	MAP2K6	0.75032556
59	BTK	0.72142310
60	STK39	0.70064888
61	GRK7	0.66013926
62	MUSK	0.64602181
63	PBK	0.64021246
64	JAK3	0.62263326
65	ZAP70	0.59477201
66	TRPM7	0.59173503
67	MAPKAPK5	0.58053517
68	TNK2	0.57142240
69	EIF2AK2	0.54037214
70	MAP2K2	0.53614193
71	IGF1R	0.53398894
72	CDK8	0.51968151
73	PLK3	0.50112202
74	DAPK2	0.48153184
75	GRK5	0.47602591
76	TBK1	0.46364360
77	CSNK1G1	0.46275556
78	ADRBK1	0.45269014
79	PIK3CG	0.44182427
80	CSK	0.43232733
81	CAMKK2	0.42145356
82	TGFBR1	0.41555655
83	RPS6KA4	0.41529798
84	CSNK1G3	0.41208489
85	DYRK2	0.39169738
86	BRSK2	0.39081671
87	PRKCA	0.38936718
88	DAPK3	0.37284172
89	ERBB3	0.37165673
90	PRKCE	0.34528126
91	PRKG2	0.33586164
92	TSSK6	0.33255135
93	CSNK2A1	0.31849840
94	PRKCD	0.30409181
95	OBSCN	0.30002724
96	CSNK2A2	0.29072784
97	HCK	0.28899884
98	MAPK13	0.28175510
99	ATR	0.27985459
100	PRKACA	0.26440451

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary immunodeficiency_Homo sapiens_hsa05340	3.69021588
2	Allograft rejection_Homo sapiens_hsa05330	3.28738176
3	Proteasome_Homo sapiens_hsa03050	3.28218064
4	Asthma_Homo sapiens_hsa05310	3.22173417
5	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.11434954
6	Graft-versus-host disease_Homo sapiens_hsa05332	3.09497981
7	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.95725141
8	Type I diabetes mellitus_Homo sapiens_hsa04940	2.74590667
9	Antigen processing and presentation_Homo sapiens_hsa04612	2.45678271
10	Oxidative phosphorylation_Homo sapiens_hsa00190	2.32548483
11	Ribosome_Homo sapiens_hsa03010	2.18933695
12	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.89648227
13	RNA polymerase_Homo sapiens_hsa03020	1.85164068
14	Parkinsons disease_Homo sapiens_hsa05012	1.81868343
15	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.77638662
16	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.76194770
17	Linoleic acid metabolism_Homo sapiens_hsa00591	1.70916771
18	Protein export_Homo sapiens_hsa03060	1.67261931
19	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.56159001
20	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.52004829
21	Rheumatoid arthritis_Homo sapiens_hsa05323	1.46630247
22	Phototransduction_Homo sapiens_hsa04744	1.46305969
23	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.37953800
24	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.35023615
25	Homologous recombination_Homo sapiens_hsa03440	1.30058855
26	Caffeine metabolism_Homo sapiens_hsa00232	1.27633437
27	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.26853539
28	Sulfur metabolism_Homo sapiens_hsa00920	1.25111170
29	Fat digestion and absorption_Homo sapiens_hsa04975	1.23055310
30	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.22578798
31	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.15965887
32	Nitrogen metabolism_Homo sapiens_hsa00910	1.13977068
33	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.10456297
34	RNA degradation_Homo sapiens_hsa03018	1.10291889
35	Propanoate metabolism_Homo sapiens_hsa00640	1.09554253
36	Peroxisome_Homo sapiens_hsa04146	1.05412658
37	Tryptophan metabolism_Homo sapiens_hsa00380	1.05032234
38	Alzheimers disease_Homo sapiens_hsa05010	1.03452982
39	Viral myocarditis_Homo sapiens_hsa05416	0.99982989
40	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.99689493
41	Huntingtons disease_Homo sapiens_hsa05016	0.99549148
42	Chemical carcinogenesis_Homo sapiens_hsa05204	0.98872007
43	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.97272404
44	Pyrimidine metabolism_Homo sapiens_hsa00240	0.96712160
45	Butanoate metabolism_Homo sapiens_hsa00650	0.95112179
46	One carbon pool by folate_Homo sapiens_hsa00670	0.93996350
47	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.93982204
48	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.90084174
49	Ether lipid metabolism_Homo sapiens_hsa00565	0.89420677
50	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.88968113
51	Fanconi anemia pathway_Homo sapiens_hsa03460	0.88503671
52	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.87434969
53	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.87387824
54	Retinol metabolism_Homo sapiens_hsa00830	0.86613507
55	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.85819152
56	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.85436327
57	Mismatch repair_Homo sapiens_hsa03430	0.84290177
58	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.81190070
59	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.81084353
60	Purine metabolism_Homo sapiens_hsa00230	0.79587630
61	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.78740606
62	Basal transcription factors_Homo sapiens_hsa03022	0.78385261
63	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.76116857
64	Leishmaniasis_Homo sapiens_hsa05140	0.76105163
65	DNA replication_Homo sapiens_hsa03030	0.74815318
66	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.70856762
67	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.70162335
68	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.69054342
69	Cardiac muscle contraction_Homo sapiens_hsa04260	0.68939505
70	Nucleotide excision repair_Homo sapiens_hsa03420	0.67397730
71	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.64657891
72	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.64502779
73	Herpes simplex infection_Homo sapiens_hsa05168	0.63727272
74	Base excision repair_Homo sapiens_hsa03410	0.62121392
75	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.61365862
76	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.61097843
77	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.59448905
78	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.58104031
79	Selenocompound metabolism_Homo sapiens_hsa00450	0.55887643
80	Fatty acid degradation_Homo sapiens_hsa00071	0.50598391
81	Regulation of autophagy_Homo sapiens_hsa04140	0.49844974
82	Olfactory transduction_Homo sapiens_hsa04740	0.48882907
83	Mineral absorption_Homo sapiens_hsa04978	0.48731349
84	Non-homologous end-joining_Homo sapiens_hsa03450	0.47339143
85	Glutathione metabolism_Homo sapiens_hsa00480	0.46869479
86	Metabolic pathways_Homo sapiens_hsa01100	0.46690177
87	Measles_Homo sapiens_hsa05162	0.45762167
88	Spliceosome_Homo sapiens_hsa03040	0.44698669
89	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.40260728
90	Fatty acid elongation_Homo sapiens_hsa00062	0.39315562
91	RNA transport_Homo sapiens_hsa03013	0.39131350
92	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.36793060
93	Renin-angiotensin system_Homo sapiens_hsa04614	0.34224771
94	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.32678307
95	Glycerolipid metabolism_Homo sapiens_hsa00561	0.31196143
96	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.29689664
97	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.27584984
98	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.27091259
99	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.26060563
100	Sulfur relay system_Homo sapiens_hsa04122	0.23954840

EEF1A1P14

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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