ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.75062413
2	positive regulation of defense response to virus by host (GO:0002230)	4.12564458
3	cellular response to exogenous dsRNA (GO:0071360)	4.05768422
4	NADH dehydrogenase complex assembly (GO:0010257)	4.05617646
5	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.05617646
6	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.05617646
7	proteasome assembly (GO:0043248)	3.73074565
8	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.72671520
9	protein complex biogenesis (GO:0070271)	3.64706296
10	GTP biosynthetic process (GO:0006183)	3.60673538
11	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.58174673
12	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.58174673
13	water-soluble vitamin biosynthetic process (GO:0042364)	3.57604643
14	mitochondrial respiratory chain complex assembly (GO:0033108)	3.34450105
15	regulation of germinal center formation (GO:0002634)	3.27211606
16	interferon-gamma secretion (GO:0072643)	3.26794809
17	piRNA metabolic process (GO:0034587)	3.26049856
18	rRNA modification (GO:0000154)	3.26031265
19	positive regulation of prostaglandin secretion (GO:0032308)	3.24663022
20	ATP synthesis coupled proton transport (GO:0015986)	3.22197580
21	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.22197580
22	protein deneddylation (GO:0000338)	3.20663727
23	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.19808834
24	pseudouridine synthesis (GO:0001522)	3.17190285
25	regulation of chronic inflammatory response (GO:0002676)	3.09946830
26	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.04288662
27	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla	3.03712719
28	UTP biosynthetic process (GO:0006228)	3.02704473
29	regulation of cellular amino acid metabolic process (GO:0006521)	3.02314083
30	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.98677602
31	regulation of regulatory T cell differentiation (GO:0045589)	2.97414811
32	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.97123912
33	L-fucose catabolic process (GO:0042355)	2.96645365
34	fucose catabolic process (GO:0019317)	2.96645365
35	L-fucose metabolic process (GO:0042354)	2.96645365
36	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.96434759
37	response to interferon-beta (GO:0035456)	2.96247226
38	regulation of defense response to virus by host (GO:0050691)	2.95923403
39	regulation of DNA endoreduplication (GO:0032875)	2.95269260
40	response to xenobiotic stimulus (GO:0009410)	2.92599219
41	cullin deneddylation (GO:0010388)	2.91638528
42	maturation of 5.8S rRNA (GO:0000460)	2.91502255
43	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.91073060
44	cytidine deamination (GO:0009972)	2.90477994
45	cytidine metabolic process (GO:0046087)	2.90477994
46	cytidine catabolic process (GO:0006216)	2.90477994
47	positive regulation of T-helper 1 type immune response (GO:0002827)	2.88755402
48	ribosomal small subunit assembly (GO:0000028)	2.86211123
49	behavioral response to nicotine (GO:0035095)	2.86059343
50	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.85685897
51	activated T cell proliferation (GO:0050798)	2.85378957
52	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.81187312
53	termination of RNA polymerase III transcription (GO:0006386)	2.80587984
54	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.80587984
55	tRNA processing (GO:0008033)	2.80390486
56	DNA damage response, signal transduction resulting in transcription (GO:0042772)	2.78641195
57	UTP metabolic process (GO:0046051)	2.76710216
58	sulfation (GO:0051923)	2.73675346
59	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.72588813
60	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.72588813
61	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.72588813
62	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.71736474
63	protein polyglutamylation (GO:0018095)	2.69283438
64	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.68899340
65	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.68899340
66	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.68520764
67	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.67820000
68	protein K6-linked ubiquitination (GO:0085020)	2.67205901
69	mesonephros development (GO:0001823)	2.66795964
70	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.66687717
71	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.66687717
72	tRNA modification (GO:0006400)	2.65453442
73	DNA methylation involved in gamete generation (GO:0043046)	2.62605796
74	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.62310247
75	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.61644106
76	response to gravity (GO:0009629)	2.60447796
77	adenosine metabolic process (GO:0046085)	2.60336945
78	preassembly of GPI anchor in ER membrane (GO:0016254)	2.60206587
79	regulation of isotype switching to IgG isotypes (GO:0048302)	2.57873305
80	sleep (GO:0030431)	2.57343495
81	regulation of T cell receptor signaling pathway (GO:0050856)	2.57098694
82	protein neddylation (GO:0045116)	2.56813669
83	protein-cofactor linkage (GO:0018065)	2.56795281
84	cellular response to dsRNA (GO:0071359)	2.56744875
85	chaperone-mediated protein transport (GO:0072321)	2.56437412
86	kynurenine metabolic process (GO:0070189)	2.54581174
87	regulation of prostaglandin secretion (GO:0032306)	2.54206120
88	auditory receptor cell stereocilium organization (GO:0060088)	2.52430177
89	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.52288407
90	CTP metabolic process (GO:0046036)	2.51585398
91	CTP biosynthetic process (GO:0006241)	2.51585398
92	positive regulation of fatty acid transport (GO:2000193)	2.51526153
93	amino acid salvage (GO:0043102)	2.50788686
94	L-methionine salvage (GO:0071267)	2.50788686
95	L-methionine biosynthetic process (GO:0071265)	2.50788686
96	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.50359955
97	regulation of T cell mediated cytotoxicity (GO:0001914)	2.50224556
98	positive regulation of DNA recombination (GO:0045911)	2.49819741
99	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.49560519
100	isotype switching (GO:0045190)	2.49560519

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.28204322
2	ELF1_17652178_ChIP-ChIP_JURKAT_Human	4.12814883
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.84447943
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.80074271
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.45442604
6	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.28189130
7	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.22159634
8	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.94598401
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.88560689
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.86254405
11	VDR_22108803_ChIP-Seq_LS180_Human	2.82927161
12	VDR_23849224_ChIP-Seq_CD4+_Human	2.66304356
13	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.46721017
14	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.40466473
15	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.37610803
16	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.33503923
17	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.32492967
18	ZNF274_21170338_ChIP-Seq_K562_Hela	2.31805926
19	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.28624021
20	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.22227830
21	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.14628464
22	ELK1_19687146_ChIP-ChIP_HELA_Human	2.11416544
23	FOXP3_21729870_ChIP-Seq_TREG_Human	2.04643984
24	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.99827626
25	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.85861471
26	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.82794547
27	EWS_26573619_Chip-Seq_HEK293_Human	1.80406688
28	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.78591530
29	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.72104811
30	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.66165419
31	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.64760492
32	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.61300750
33	MYC_18940864_ChIP-ChIP_HL60_Human	1.59169059
34	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.55514457
35	GATA3_26560356_Chip-Seq_TH2_Human	1.55369156
36	CIITA_25753668_ChIP-Seq_RAJI_Human	1.55357966
37	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.51641076
38	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.45706039
39	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.43827536
40	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.42134171
41	TP53_22573176_ChIP-Seq_HFKS_Human	1.41054043
42	FUS_26573619_Chip-Seq_HEK293_Human	1.30139505
43	IRF1_19129219_ChIP-ChIP_H3396_Human	1.29606580
44	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.29503724
45	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.28514888
46	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.27881360
47	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.27231295
48	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.25260045
49	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.24994068
50	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.24217516
51	IGF1R_20145208_ChIP-Seq_DFB_Human	1.23175844
52	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.22894181
53	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.22894181
54	MYB_26560356_Chip-Seq_TH2_Human	1.22502983
55	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.21866466
56	GBX2_23144817_ChIP-Seq_PC3_Human	1.21460660
57	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.21054264
58	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.20802828
59	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.20503123
60	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.19897104
61	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.17628694
62	AR_20517297_ChIP-Seq_VCAP_Human	1.16245762
63	ER_23166858_ChIP-Seq_MCF-7_Human	1.15524252
64	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.13613977
65	SOX2_19829295_ChIP-Seq_ESCs_Human	1.12831904
66	NANOG_19829295_ChIP-Seq_ESCs_Human	1.12831904
67	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.12317714
68	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.11385879
69	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.09032276
70	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.06124500
71	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.05888974
72	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.05586581
73	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.04769103
74	TAF2_19829295_ChIP-Seq_ESCs_Human	1.03541777
75	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.02665392
76	TTF2_22483619_ChIP-Seq_HELA_Human	1.02215972
77	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.01507253
78	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.01218138
79	NCOR_22424771_ChIP-Seq_293T_Human	1.00541710
80	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.99925853
81	CBP_20019798_ChIP-Seq_JUKART_Human	0.99630016
82	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.99630016
83	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.99564843
84	NANOG_20526341_ChIP-Seq_ESCs_Human	0.99383931
85	DCP1A_22483619_ChIP-Seq_HELA_Human	0.99276478
86	P300_19829295_ChIP-Seq_ESCs_Human	0.98365100
87	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.97996004
88	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.96497010
89	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.95706632
90	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.95679267
91	HOXB7_26014856_ChIP-Seq_BT474_Human	0.95431991
92	E2F4_17652178_ChIP-ChIP_JURKAT_Human	0.94998591
93	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.94116868
94	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.94071106
95	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.93968977
96	GABP_19822575_ChIP-Seq_HepG2_Human	0.92360406
97	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.91791267
98	RUNX_20019798_ChIP-Seq_JUKART_Human	0.91377400
99	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.90909065
100	GATA3_27048872_Chip-Seq_THYMUS_Human	0.90529115

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	3.49228006
2	MP0002138_abnormal_hepatobiliary_system	3.43199961
3	MP0002736_abnormal_nociception_after	3.14468825
4	MP0001835_abnormal_antigen_presentation	3.10949308
5	MP0001968_abnormal_touch/_nociception	2.85274698
6	MP0000685_abnormal_immune_system	2.67887899
7	MP0005646_abnormal_pituitary_gland	2.66256195
8	MP0004885_abnormal_endolymph	2.63000640
9	MP0002148_abnormal_hypersensitivity_rea	2.44958800
10	MP0006072_abnormal_retinal_apoptosis	2.41497443
11	MP0003806_abnormal_nucleotide_metabolis	2.40906858
12	MP0002163_abnormal_gland_morphology	2.36426262
13	MP0008877_abnormal_DNA_methylation	2.30330487
14	MP0003724_increased_susceptibility_to	2.19238264
15	MP0008872_abnormal_physiological_respon	2.18540856
16	MP0008875_abnormal_xenobiotic_pharmacok	2.15998770
17	MP0002102_abnormal_ear_morphology	2.07276408
18	MP0001800_abnormal_humoral_immune	1.93790262
19	MP0008058_abnormal_DNA_repair	1.87663130
20	MP0002876_abnormal_thyroid_physiology	1.84616783
21	MP0005084_abnormal_gallbladder_morpholo	1.82209623
22	MP0005000_abnormal_immune_tolerance	1.80175079
23	MP0000613_abnormal_salivary_gland	1.79140757
24	MP0009785_altered_susceptibility_to	1.78153179
25	MP0003436_decreased_susceptibility_to	1.71424769
26	MP0003786_premature_aging	1.69237892
27	MP0009764_decreased_sensitivity_to	1.68015680
28	MP0002006_tumorigenesis	1.66827910
29	MP0005389_reproductive_system_phenotype	1.64782223
30	MP0001348_abnormal_lacrimal_gland	1.64557173
31	MP0003866_abnormal_defecation	1.63962516
32	MP0002723_abnormal_immune_serum	1.56457365
33	MP0009333_abnormal_splenocyte_physiolog	1.49162823
34	MP0002452_abnormal_antigen_presenting	1.48569881
35	MP0005551_abnormal_eye_electrophysiolog	1.47080548
36	MP0002160_abnormal_reproductive_system	1.46829085
37	MP0003718_maternal_effect	1.46551669
38	MP0002166_altered_tumor_susceptibility	1.40512257
39	MP0002420_abnormal_adaptive_immunity	1.39237671
40	MP0001819_abnormal_immune_cell	1.38381389
41	MP0005379_endocrine/exocrine_gland_phen	1.35921821
42	MP0001905_abnormal_dopamine_level	1.34949423
43	MP0000383_abnormal_hair_follicle	1.34084783
44	MP0001790_abnormal_immune_system	1.34001974
45	MP0005387_immune_system_phenotype	1.34001974
46	MP0001873_stomach_inflammation	1.33931190
47	MP0001919_abnormal_reproductive_system	1.33157678
48	MP0001501_abnormal_sleep_pattern	1.31065805
49	MP0005253_abnormal_eye_physiology	1.26452946
50	MP0004147_increased_porphyrin_level	1.24152737
51	MP0005645_abnormal_hypothalamus_physiol	1.23020339
52	MP0004145_abnormal_muscle_electrophysio	1.17090951
53	MP0003646_muscle_fatigue	1.15597436
54	MP0000372_irregular_coat_pigmentation	1.14693101
55	MP0003252_abnormal_bile_duct	1.14641950
56	MP0003950_abnormal_plasma_membrane	1.13611899
57	MP0008775_abnormal_heart_ventricle	1.11862173
58	MP0010155_abnormal_intestine_physiology	1.11755558
59	MP0005075_abnormal_melanosome_morpholog	1.10135954
60	MP0003763_abnormal_thymus_physiology	1.07894642
61	MP0006292_abnormal_olfactory_placode	1.06918671
62	MP0001533_abnormal_skeleton_physiology	1.05466254
63	MP0003195_calcinosis	1.01738840
64	MP0001845_abnormal_inflammatory_respons	0.99422942
65	MP0005410_abnormal_fertilization	0.98351133
66	MP0005025_abnormal_response_to	0.97531055
67	MP0004742_abnormal_vestibular_system	0.97001806
68	MP0001440_abnormal_grooming_behavior	0.95743297
69	MP0001986_abnormal_taste_sensitivity	0.95421751
70	MP0002272_abnormal_nervous_system	0.94673042
71	MP0003638_abnormal_response/metabolism_	0.93536601
72	MP0000689_abnormal_spleen_morphology	0.93179183
73	MP0000647_abnormal_sebaceous_gland	0.92851540
74	MP0000427_abnormal_hair_cycle	0.91869731
75	MP0001542_abnormal_bone_strength	0.90374615
76	MP0002419_abnormal_innate_immunity	0.89963633
77	MP0000716_abnormal_immune_system	0.89960616
78	MP0002282_abnormal_trachea_morphology	0.89483609
79	MP0002405_respiratory_system_inflammati	0.88882514
80	MP0002733_abnormal_thermal_nociception	0.86544698
81	MP0002398_abnormal_bone_marrow	0.86391144
82	MP0004142_abnormal_muscle_tone	0.85891018
83	MP0005332_abnormal_amino_acid	0.83991924
84	MP0005165_increased_susceptibility_to	0.83091934
85	MP0000230_abnormal_systemic_arterial	0.82753675
86	MP0001765_abnormal_ion_homeostasis	0.79743628
87	MP0005360_urolithiasis	0.79529081
88	MP0002722_abnormal_immune_system	0.79212971
89	MP0002210_abnormal_sex_determination	0.77653335
90	MP0006036_abnormal_mitochondrial_physio	0.77536786
91	MP0008469_abnormal_protein_level	0.76509234
92	MP0001486_abnormal_startle_reflex	0.76260133
93	MP0002277_abnormal_respiratory_mucosa	0.76065657
94	MP0001502_abnormal_circadian_rhythm	0.74728718
95	MP0002429_abnormal_blood_cell	0.74372860
96	MP0003011_delayed_dark_adaptation	0.72185834
97	MP0005377_hearing/vestibular/ear_phenot	0.71415588
98	MP0003878_abnormal_ear_physiology	0.71415588
99	MP0001529_abnormal_vocalization	0.70678680
100	MP0009643_abnormal_urine_homeostasis	0.70076465

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Elevated erythrocyte sedimentation rate (HP:0003565)	3.79270014
2	Abolished electroretinogram (ERG) (HP:0000550)	3.47336120
3	IgG deficiency (HP:0004315)	3.46784233
4	Acute necrotizing encephalopathy (HP:0006965)	3.44954144
5	Mitochondrial inheritance (HP:0001427)	3.43814240
6	Pancreatic cysts (HP:0001737)	3.42442681
7	Conjunctival hamartoma (HP:0100780)	3.30389692
8	Hepatocellular necrosis (HP:0001404)	3.24621539
9	Stomatitis (HP:0010280)	3.23441148
10	Increased CSF lactate (HP:0002490)	3.21730656
11	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.20961278
12	Abnormality of the renal cortex (HP:0011035)	3.13449064
13	Abnormal mitochondria in muscle tissue (HP:0008316)	3.10374283
14	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.08621945
15	Acute encephalopathy (HP:0006846)	3.07579586
16	Congenital stationary night blindness (HP:0007642)	3.03437695
17	Progressive macrocephaly (HP:0004481)	3.01254847
18	Hepatic necrosis (HP:0002605)	2.92725715
19	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.91498453
20	Abnormality of alanine metabolism (HP:0010916)	2.91498453
21	Hyperalaninemia (HP:0003348)	2.91498453
22	Prostate neoplasm (HP:0100787)	2.87875378
23	Abnormality of the prostate (HP:0008775)	2.87856845
24	Pendular nystagmus (HP:0012043)	2.87714374
25	Short tibia (HP:0005736)	2.83214160
26	Hypoplasia of the uterus (HP:0000013)	2.80647682
27	Renal cortical cysts (HP:0000803)	2.75681956
28	Abnormality of midbrain morphology (HP:0002418)	2.74933385
29	Molar tooth sign on MRI (HP:0002419)	2.74933385
30	Keratoconus (HP:0000563)	2.71480578
31	Increased corneal curvature (HP:0100692)	2.71480578
32	Abnormality of the proximal phalanges of the hand (HP:0009834)	2.67338310
33	Nephronophthisis (HP:0000090)	2.62562808
34	Aplasia/hypoplasia of the uterus (HP:0008684)	2.62096361
35	Abnormal number of erythroid precursors (HP:0012131)	2.60439279
36	Pancreatic fibrosis (HP:0100732)	2.59007964
37	Increased serum lactate (HP:0002151)	2.57785829
38	Congenital, generalized hypertrichosis (HP:0004540)	2.57177560
39	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.55669146
40	Abnormal rod and cone electroretinograms (HP:0008323)	2.54466276
41	True hermaphroditism (HP:0010459)	2.51574475
42	3-Methylglutaconic aciduria (HP:0003535)	2.50635150
43	Attenuation of retinal blood vessels (HP:0007843)	2.46657289
44	Optic disc pallor (HP:0000543)	2.33828005
45	Lactic acidosis (HP:0003128)	2.33691477
46	Abnormality of the renal medulla (HP:0100957)	2.32973567
47	Asplenia (HP:0001746)	2.32737363
48	Constricted visual fields (HP:0001133)	2.31472603
49	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.27496886
50	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.26687579
51	Cerebral edema (HP:0002181)	2.25787743
52	Congenital sensorineural hearing impairment (HP:0008527)	2.24990680
53	Stomach cancer (HP:0012126)	2.24019465
54	Pulmonary infiltrates (HP:0002113)	2.21316891
55	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.20544501
56	Hypoproteinemia (HP:0003075)	2.19973190
57	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.17522253
58	Increased IgM level (HP:0003496)	2.17242655
59	Abnormality of cells of the erythroid lineage (HP:0012130)	2.17030628
60	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.10694913
61	Hamartoma of the eye (HP:0010568)	2.08946958
62	Fibular aplasia (HP:0002990)	2.08650184
63	Methylmalonic acidemia (HP:0002912)	2.06747612
64	Decreased central vision (HP:0007663)	2.05174349
65	Abnormality of T cell physiology (HP:0011840)	2.04721395
66	Polydipsia (HP:0001959)	2.04332063
67	Abnormal drinking behavior (HP:0030082)	2.04332063
68	Myositis (HP:0100614)	1.97570820
69	Increased hepatocellular lipid droplets (HP:0006565)	1.97160841
70	Absent thumb (HP:0009777)	1.96185951
71	Lipid accumulation in hepatocytes (HP:0006561)	1.95818339
72	Type 2 muscle fiber atrophy (HP:0003554)	1.95651499
73	Furrowed tongue (HP:0000221)	1.94869450
74	Methylmalonic aciduria (HP:0012120)	1.94602892
75	Renal Fanconi syndrome (HP:0001994)	1.91373722
76	Abnormality of the middle phalanges of the toes (HP:0010183)	1.91258169
77	Type I transferrin isoform profile (HP:0003642)	1.88880528
78	Adrenal hypoplasia (HP:0000835)	1.86300500
79	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.85321708
80	Abnormality of T cells (HP:0002843)	1.85037775
81	Generalized aminoaciduria (HP:0002909)	1.80604826
82	Respiratory failure (HP:0002878)	1.79477172
83	Reduced subcutaneous adipose tissue (HP:0003758)	1.78915188
84	Hypoplasia of the ulna (HP:0003022)	1.77638771
85	Adactyly (HP:0009776)	1.77135225
86	Pancytopenia (HP:0001876)	1.75311296
87	Abnormality of the ileum (HP:0001549)	1.74074659
88	Lethargy (HP:0001254)	1.73263127
89	Polyuria (HP:0000103)	1.73156759
90	Bone cyst (HP:0012062)	1.71320365
91	Cystic liver disease (HP:0006706)	1.70305161
92	Colon cancer (HP:0003003)	1.69808986
93	Chorioretinal atrophy (HP:0000533)	1.68810298
94	Palpitations (HP:0001962)	1.68654063
95	Abnormality of eosinophils (HP:0001879)	1.68079765
96	Autoimmune hemolytic anemia (HP:0001890)	1.66475370
97	Retrobulbar optic neuritis (HP:0100654)	1.65801817
98	Optic neuritis (HP:0100653)	1.65801817
99	Leukodystrophy (HP:0002415)	1.65746188
100	Aplasia/Hypoplasia of the ulna (HP:0006495)	1.65538116

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TLK1	4.17655650
2	NME2	3.68194466
3	VRK2	3.60838076
4	TAOK3	3.58090461
5	NUAK1	3.29958066
6	ZAK	2.82263687
7	TXK	2.74220176
8	MAP4K2	2.52511534
9	BCKDK	2.40945141
10	ADRBK2	2.16738836
11	MAPKAPK3	2.12145610
12	FRK	2.07214081
13	GRK1	1.89717417
14	VRK1	1.87217480
15	BUB1	1.82222207
16	TIE1	1.70588618
17	CSNK1G3	1.62181150
18	MAP4K1	1.60277361
19	MST4	1.54589603
20	GRK6	1.51405747
21	TEC	1.45932405
22	DAPK1	1.44741891
23	PHKG2	1.43724115
24	PHKG1	1.43724115
25	CSNK1A1L	1.43217374
26	IKBKB	1.39980967
27	BMPR1B	1.37737920
28	TAF1	1.36683776
29	WNK4	1.34468131
30	MAP3K14	1.30804767
31	TSSK6	1.30028247
32	CSNK1G1	1.28287644
33	CSNK1G2	1.26623363
34	STK16	1.24480158
35	CDK19	1.18707239
36	SCYL2	1.16428182
37	GRK5	1.11768590
38	NEK1	1.10626072
39	PINK1	1.09909799
40	FES	0.99884886
41	ITK	0.99513201
42	KDR	0.97478168
43	EIF2AK3	0.97398587
44	EIF2AK2	0.92652865
45	OXSR1	0.88864400
46	KIT	0.83983876
47	CDK8	0.82948718
48	LMTK2	0.79399021
49	INSRR	0.78952617
50	MAPKAPK5	0.77393739
51	TESK2	0.77330214
52	MAP3K12	0.76060389
53	PLK3	0.75660168
54	SYK	0.71932319
55	RPS6KA5	0.69338514
56	PTK2B	0.69314241
57	FLT3	0.67459061
58	MYLK	0.67096253
59	MAP2K6	0.66788381
60	WNK3	0.66028044
61	IKBKE	0.65607459
62	ADRBK1	0.63816128
63	MAP2K2	0.62456636
64	JAK3	0.59392651
65	PRKCQ	0.58923234
66	RPS6KB2	0.54759087
67	CHUK	0.54490239
68	MUSK	0.54255836
69	TGFBR1	0.52218808
70	CSNK1A1	0.52159515
71	MKNK1	0.51975901
72	LIMK1	0.49712253
73	TBK1	0.49241680
74	BMPR2	0.48766777
75	GRK7	0.47606073
76	SRPK1	0.46333345
77	DYRK2	0.46119758
78	PLK2	0.45660561
79	LCK	0.45242200
80	BTK	0.44738994
81	TRIM28	0.44208705
82	LYN	0.44184732
83	STK38L	0.43556854
84	CAMKK2	0.42549427
85	IGF1R	0.40881387
86	PRKCE	0.40720557
87	EIF2AK1	0.39632891
88	STK39	0.39395140
89	ABL1	0.39189423
90	CSF1R	0.39044463
91	PASK	0.34792811
92	AURKA	0.34585432
93	CAMK2D	0.33982918
94	CCNB1	0.32709907
95	ERBB3	0.31827995
96	PRKCI	0.31457654
97	CSNK2A1	0.31044738
98	DAPK2	0.29925514
99	NME1	0.29575327
100	DAPK3	0.28889182

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	4.06209008
2	Proteasome_Homo sapiens_hsa03050	3.64101149
3	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.40770567
4	Allograft rejection_Homo sapiens_hsa05330	3.40212777
5	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.17403711
6	Graft-versus-host disease_Homo sapiens_hsa05332	2.69487545
7	Type I diabetes mellitus_Homo sapiens_hsa04940	2.65929499
8	RNA polymerase_Homo sapiens_hsa03020	2.38310850
9	Ribosome_Homo sapiens_hsa03010	2.30289401
10	Oxidative phosphorylation_Homo sapiens_hsa00190	2.28851022
11	One carbon pool by folate_Homo sapiens_hsa00670	2.17022451
12	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	2.04776108
13	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.94518955
14	Antigen processing and presentation_Homo sapiens_hsa04612	1.82111984
15	Primary immunodeficiency_Homo sapiens_hsa05340	1.77515186
16	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.75544869
17	Protein export_Homo sapiens_hsa03060	1.67419510
18	Parkinsons disease_Homo sapiens_hsa05012	1.67388933
19	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.66338571
20	Rheumatoid arthritis_Homo sapiens_hsa05323	1.61812094
21	RNA degradation_Homo sapiens_hsa03018	1.44757723
22	Linoleic acid metabolism_Homo sapiens_hsa00591	1.39603159
23	Homologous recombination_Homo sapiens_hsa03440	1.37316237
24	Nitrogen metabolism_Homo sapiens_hsa00910	1.36210916
25	Phototransduction_Homo sapiens_hsa04744	1.35739220
26	Sulfur metabolism_Homo sapiens_hsa00920	1.33242214
27	Pyrimidine metabolism_Homo sapiens_hsa00240	1.27643336
28	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.25262960
29	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.22915614
30	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.21544626
31	Viral myocarditis_Homo sapiens_hsa05416	1.16518166
32	Selenocompound metabolism_Homo sapiens_hsa00450	1.15344306
33	Alzheimers disease_Homo sapiens_hsa05010	1.12532979
34	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.12137565
35	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.11353079
36	Mismatch repair_Homo sapiens_hsa03430	1.10216849
37	Huntingtons disease_Homo sapiens_hsa05016	1.06685847
38	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.06464732
39	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.05051729
40	Purine metabolism_Homo sapiens_hsa00230	1.04949992
41	Nucleotide excision repair_Homo sapiens_hsa03420	1.03752963
42	Spliceosome_Homo sapiens_hsa03040	1.03502470
43	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.03096232
44	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.02815967
45	Basal transcription factors_Homo sapiens_hsa03022	1.01874925
46	Fanconi anemia pathway_Homo sapiens_hsa03460	1.01671511
47	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.00642725
48	Regulation of autophagy_Homo sapiens_hsa04140	0.93675232
49	Non-homologous end-joining_Homo sapiens_hsa03450	0.93483991
50	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.91734694
51	RNA transport_Homo sapiens_hsa03013	0.91050225
52	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.88769646
53	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.86328919
54	Base excision repair_Homo sapiens_hsa03410	0.86098119
55	DNA replication_Homo sapiens_hsa03030	0.82425964
56	Ether lipid metabolism_Homo sapiens_hsa00565	0.78371038
57	Caffeine metabolism_Homo sapiens_hsa00232	0.76135230
58	Fatty acid elongation_Homo sapiens_hsa00062	0.75808756
59	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.75601509
60	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.74668368
61	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.73999003
62	Herpes simplex infection_Homo sapiens_hsa05168	0.70303456
63	Chemical carcinogenesis_Homo sapiens_hsa05204	0.69467822
64	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.69196163
65	Cardiac muscle contraction_Homo sapiens_hsa04260	0.67223933
66	Peroxisome_Homo sapiens_hsa04146	0.66252962
67	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.64349557
68	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.63605084
69	Propanoate metabolism_Homo sapiens_hsa00640	0.62686918
70	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.61988405
71	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.61012487
72	Tryptophan metabolism_Homo sapiens_hsa00380	0.60198828
73	Leishmaniasis_Homo sapiens_hsa05140	0.59126927
74	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.58694280
75	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.57428058
76	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.57014806
77	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.56763669
78	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.56593340
79	Collecting duct acid secretion_Homo sapiens_hsa04966	0.53316630
80	Salivary secretion_Homo sapiens_hsa04970	0.52196208
81	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.51671953
82	Retinol metabolism_Homo sapiens_hsa00830	0.49580123
83	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.47474641
84	Metabolic pathways_Homo sapiens_hsa01100	0.44771845
85	Measles_Homo sapiens_hsa05162	0.41557636
86	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.37950628
87	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.37546842
88	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.36953512
89	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.36352033
90	Glutathione metabolism_Homo sapiens_hsa00480	0.35879932
91	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.34866301
92	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.31794169
93	Morphine addiction_Homo sapiens_hsa05032	0.29777560
94	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.28835245
95	Taste transduction_Homo sapiens_hsa04742	0.27939386
96	Fat digestion and absorption_Homo sapiens_hsa04975	0.26661796
97	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.23046385
98	Legionellosis_Homo sapiens_hsa05134	0.22184123
99	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.21532878
100	Olfactory transduction_Homo sapiens_hsa04740	0.20609469

EEF1A1P15

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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