ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	6.37894018
2	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	5.00132379
3	cytidine catabolic process (GO:0006216)	4.81986372
4	cytidine deamination (GO:0009972)	4.81986372
5	cytidine metabolic process (GO:0046087)	4.81986372
6	ATP synthesis coupled proton transport (GO:0015986)	4.43818939
7	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.43818939
8	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.38915756
9	ribosomal small subunit assembly (GO:0000028)	4.15931136
10	pyrimidine ribonucleoside catabolic process (GO:0046133)	4.06472646
11	water-soluble vitamin biosynthetic process (GO:0042364)	4.00684030
12	protein neddylation (GO:0045116)	3.95628422
13	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.74631725
14	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.74631725
15	proteasome assembly (GO:0043248)	3.72436265
16	regulation of cellular amino acid metabolic process (GO:0006521)	3.51440911
17	platelet dense granule organization (GO:0060155)	3.48799169
18	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.47085542
19	protein complex biogenesis (GO:0070271)	3.43066349
20	rRNA modification (GO:0000154)	3.36041027
21	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.35452658
22	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.33983651
23	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.30480781
24	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.27974228
25	regulation of regulatory T cell differentiation (GO:0045589)	3.25973268
26	GTP biosynthetic process (GO:0006183)	3.25872495
27	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.21672179
28	regulation of isotype switching to IgG isotypes (GO:0048302)	3.21162627
29	electron transport chain (GO:0022900)	3.19847466
30	respiratory electron transport chain (GO:0022904)	3.19253412
31	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.18858882
32	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.18858882
33	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.18858882
34	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.15772843
35	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.15772843
36	mitochondrial respiratory chain complex assembly (GO:0033108)	3.15605031
37	pseudouridine synthesis (GO:0001522)	3.14470998
38	response to pheromone (GO:0019236)	3.10303872
39	respiratory chain complex IV assembly (GO:0008535)	3.08305740
40	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.06893122
41	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	3.06460047
42	signal transduction involved in DNA integrity checkpoint (GO:0072401)	3.03234293
43	signal transduction involved in DNA damage checkpoint (GO:0072422)	3.03234293
44	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.00370965
45	NADH dehydrogenase complex assembly (GO:0010257)	3.00370965
46	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.00370965
47	regulation of chronic inflammatory response (GO:0002676)	2.99175612
48	positive regulation of defense response to virus by host (GO:0002230)	2.99134708
49	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.98845518
50	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.97538673
51	ribosomal large subunit biogenesis (GO:0042273)	2.93312145
52	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.92655035
53	negative regulation of ligase activity (GO:0051352)	2.90961080
54	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.90961080
55	negative T cell selection (GO:0043383)	2.90828215
56	cytochrome complex assembly (GO:0017004)	2.89815178
57	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.89661118
58	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.88245739
59	chaperone-mediated protein transport (GO:0072321)	2.86182250
60	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.85924253
61	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.85264913
62	Arp2/3 complex-mediated actin nucleation (GO:0034314)	2.83419248
63	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	2.81655110
64	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.80126269
65	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.76941701
66	sequestering of actin monomers (GO:0042989)	2.76307456
67	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.75223170
68	actin nucleation (GO:0045010)	2.73308113
69	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.70007200
70	rRNA methylation (GO:0031167)	2.68876174
71	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	2.68061340
72	regulation of T cell mediated cytotoxicity (GO:0001914)	2.67634399
73	response to interferon-beta (GO:0035456)	2.64591172
74	UTP biosynthetic process (GO:0006228)	2.64173352
75	amino acid salvage (GO:0043102)	2.63772325
76	L-methionine salvage (GO:0071267)	2.63772325
77	L-methionine biosynthetic process (GO:0071265)	2.63772325
78	cellular response to interleukin-15 (GO:0071350)	2.63671522
79	maturation of SSU-rRNA (GO:0030490)	2.63104510
80	regulation of T cell receptor signaling pathway (GO:0050856)	2.62317340
81	positive T cell selection (GO:0043368)	2.59992567
82	ATP biosynthetic process (GO:0006754)	2.59228647
83	protein deneddylation (GO:0000338)	2.58175716
84	regulation of leukocyte mediated cytotoxicity (GO:0001910)	2.57891131
85	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.57202711
86	termination of RNA polymerase III transcription (GO:0006386)	2.57202711
87	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	2.56558999
88	hydrogen ion transmembrane transport (GO:1902600)	2.53475113
89	mannosylation (GO:0097502)	2.52893905
90	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.52876303
91	cullin deneddylation (GO:0010388)	2.52590827
92	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.52140010
93	regulation of cellular amine metabolic process (GO:0033238)	2.51562056
94	positive regulation of natural killer cell mediated immunity (GO:0002717)	2.51237300
95	mast cell activation (GO:0045576)	2.50907970
96	tRNA processing (GO:0008033)	2.50894539
97	DNA damage response, signal transduction by p53 class mediator (GO:0030330)	2.50845103
98	translation (GO:0006412)	2.50778953
99	positive regulation of cell cycle arrest (GO:0071158)	2.50735959
100	purine-containing compound salvage (GO:0043101)	2.49360077

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.00481880
2	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.89612054
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.88006231
4	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.80943302
5	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.35403291
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.31149255
7	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.19380147
8	VDR_22108803_ChIP-Seq_LS180_Human	2.79215662
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.75599460
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.74381112
11	VDR_23849224_ChIP-Seq_CD4+_Human	2.68043737
12	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.62179327
13	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.61809371
14	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.51564418
15	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.44339279
16	ZNF274_21170338_ChIP-Seq_K562_Hela	2.44140974
17	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.37729845
18	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.29609960
19	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.28036701
20	ELK1_19687146_ChIP-ChIP_HELA_Human	2.19411137
21	FOXP3_21729870_ChIP-Seq_TREG_Human	2.15961949
22	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.00285612
23	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.95442386
24	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.90985784
25	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.89899567
26	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.89719392
27	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.86721322
28	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.81217243
29	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.80803558
30	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.72761006
31	IGF1R_20145208_ChIP-Seq_DFB_Human	1.60676469
32	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.58359229
33	MYC_18940864_ChIP-ChIP_HL60_Human	1.55205154
34	GATA3_26560356_Chip-Seq_TH2_Human	1.54818196
35	MYB_26560356_Chip-Seq_TH2_Human	1.51840189
36	TP53_22573176_ChIP-Seq_HFKS_Human	1.49973346
37	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.48816062
38	EWS_26573619_Chip-Seq_HEK293_Human	1.47949616
39	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.46362757
40	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.41630432
41	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.40776858
42	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.40170563
43	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.40170563
44	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.38205334
45	AR_20517297_ChIP-Seq_VCAP_Human	1.36497832
46	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.34803942
47	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.34737198
48	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.30526749
49	FUS_26573619_Chip-Seq_HEK293_Human	1.25807731
50	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.24177177
51	NANOG_19829295_ChIP-Seq_ESCs_Human	1.24120003
52	SOX2_19829295_ChIP-Seq_ESCs_Human	1.24120003
53	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.23774350
54	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.23631587
55	IRF1_19129219_ChIP-ChIP_H3396_Human	1.22979660
56	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.22696927
57	ER_23166858_ChIP-Seq_MCF-7_Human	1.21273068
58	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.21158271
59	TAF15_26573619_Chip-Seq_HEK293_Human	1.20050505
60	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.18141848
61	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.17539839
62	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.16587333
63	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.14345344
64	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.13930100
65	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.13809250
66	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.12614910
67	P300_19829295_ChIP-Seq_ESCs_Human	1.12390013
68	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.12085202
69	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.12073579
70	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.10446585
71	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.10171738
72	NCOR_22424771_ChIP-Seq_293T_Human	1.08907848
73	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.08460718
74	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.07908903
75	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.07574857
76	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.07254583
77	GATA3_27048872_Chip-Seq_THYMUS_Human	1.05349218
78	TTF2_22483619_ChIP-Seq_HELA_Human	1.05291361
79	RUNX_20019798_ChIP-Seq_JUKART_Human	1.04849385
80	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.04234301
81	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.04182951
82	NANOG_20526341_ChIP-Seq_ESCs_Human	1.02422648
83	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.02170679
84	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.02077584
85	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.01994214
86	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.00659003
87	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.00006144
88	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.99470323
89	DCP1A_22483619_ChIP-Seq_HELA_Human	0.98885141
90	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.98191684
91	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.98018358
92	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.96787044
93	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.96759340
94	CBP_20019798_ChIP-Seq_JUKART_Human	0.96759340
95	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.96595105
96	TAF2_19829295_ChIP-Seq_ESCs_Human	0.96521180
97	GABP_19822575_ChIP-Seq_HepG2_Human	0.95344367
98	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.95111162
99	HTT_18923047_ChIP-ChIP_STHdh_Human	0.93562211
100	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.91850803

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	4.16320879
2	MP0001835_abnormal_antigen_presentation	3.46923845
3	MP0003646_muscle_fatigue	2.67181945
4	MP0009785_altered_susceptibility_to	2.44178896
5	MP0006072_abnormal_retinal_apoptosis	2.43903088
6	MP0002102_abnormal_ear_morphology	2.41279998
7	MP0005645_abnormal_hypothalamus_physiol	2.28780637
8	MP0000372_irregular_coat_pigmentation	2.24555977
9	MP0008872_abnormal_physiological_respon	2.21561113
10	MP0002166_altered_tumor_susceptibility	2.08767300
11	MP0008875_abnormal_xenobiotic_pharmacok	2.05829228
12	MP0005084_abnormal_gallbladder_morpholo	2.04487981
13	MP0008877_abnormal_DNA_methylation	2.03648958
14	MP0002148_abnormal_hypersensitivity_rea	2.03092258
15	MP0002138_abnormal_hepatobiliary_system	1.97766203
16	MP0001800_abnormal_humoral_immune	1.96513904
17	MP0005000_abnormal_immune_tolerance	1.92028168
18	MP0000685_abnormal_immune_system	1.91862593
19	MP0003195_calcinosis	1.91013902
20	MP0004147_increased_porphyrin_level	1.90366150
21	MP0003786_premature_aging	1.86163274
22	MP0001873_stomach_inflammation	1.85087501
23	MP0002006_tumorigenesis	1.81337687
24	MP0003763_abnormal_thymus_physiology	1.81144122
25	MP0005646_abnormal_pituitary_gland	1.80728447
26	MP0005075_abnormal_melanosome_morpholog	1.78349906
27	MP0009333_abnormal_splenocyte_physiolog	1.77174212
28	MP0003806_abnormal_nucleotide_metabolis	1.77166462
29	MP0002876_abnormal_thyroid_physiology	1.77026356
30	MP0008058_abnormal_DNA_repair	1.76557926
31	MP0002163_abnormal_gland_morphology	1.70260289
32	MP0002723_abnormal_immune_serum	1.66279985
33	MP0003866_abnormal_defecation	1.65894454
34	MP0005387_immune_system_phenotype	1.64245868
35	MP0001790_abnormal_immune_system	1.64245868
36	MP0002837_dystrophic_cardiac_calcinosis	1.63780428
37	MP0002420_abnormal_adaptive_immunity	1.56952187
38	MP0001819_abnormal_immune_cell	1.53244486
39	MP0006292_abnormal_olfactory_placode	1.51409804
40	MP0005551_abnormal_eye_electrophysiolog	1.50179818
41	MP0001919_abnormal_reproductive_system	1.49780115
42	MP0002736_abnormal_nociception_after	1.47628818
43	MP0002452_abnormal_antigen_presenting	1.43754331
44	MP0001968_abnormal_touch/_nociception	1.43106301
45	MP0005389_reproductive_system_phenotype	1.41765827
46	MP0004145_abnormal_muscle_electrophysio	1.38652975
47	MP0009764_decreased_sensitivity_to	1.36364931
48	MP0005379_endocrine/exocrine_gland_phen	1.33003002
49	MP0005253_abnormal_eye_physiology	1.32978386
50	MP0005025_abnormal_response_to	1.32867098
51	MP0003724_increased_susceptibility_to	1.30572426
52	MP0003011_delayed_dark_adaptation	1.29605381
53	MP0004885_abnormal_endolymph	1.27333411
54	MP0001986_abnormal_taste_sensitivity	1.25918298
55	MP0010155_abnormal_intestine_physiology	1.25059025
56	MP0001905_abnormal_dopamine_level	1.22597477
57	MP0009379_abnormal_foot_pigmentation	1.20951776
58	MP0001764_abnormal_homeostasis	1.20590768
59	MP0002398_abnormal_bone_marrow	1.20346988
60	MP0006036_abnormal_mitochondrial_physio	1.17423575
61	MP0000716_abnormal_immune_system	1.17370201
62	MP0000689_abnormal_spleen_morphology	1.13972243
63	MP0001845_abnormal_inflammatory_respons	1.13271969
64	MP0004142_abnormal_muscle_tone	1.12824669
65	MP0003252_abnormal_bile_duct	1.12358260
66	MP0006082_CNS_inflammation	1.10040460
67	MP0008995_early_reproductive_senescence	1.07278046
68	MP0005410_abnormal_fertilization	1.00895128
69	MP0002722_abnormal_immune_system	0.98669830
70	MP0001529_abnormal_vocalization	0.98205734
71	MP0002160_abnormal_reproductive_system	0.97899573
72	MP0005636_abnormal_mineral_homeostasis	0.95795944
73	MP0002693_abnormal_pancreas_physiology	0.95172059
74	MP0002405_respiratory_system_inflammati	0.94318863
75	MP0003186_abnormal_redox_activity	0.92356605
76	MP0002429_abnormal_blood_cell	0.91979982
77	MP0008469_abnormal_protein_level	0.88946054
78	MP0000703_abnormal_thymus_morphology	0.88902128
79	MP0003878_abnormal_ear_physiology	0.86079414
80	MP0005377_hearing/vestibular/ear_phenot	0.86079414
81	MP0001501_abnormal_sleep_pattern	0.85605164
82	MP0006035_abnormal_mitochondrial_morpho	0.83813485
83	MP0009697_abnormal_copulation	0.83209679
84	MP0001853_heart_inflammation	0.83193310
85	MP0002277_abnormal_respiratory_mucosa	0.82915040
86	MP0003718_maternal_effect	0.81541754
87	MP0003436_decreased_susceptibility_to	0.80062162
88	MP0005085_abnormal_gallbladder_physiolo	0.79264374
89	MP0002419_abnormal_innate_immunity	0.77524348
90	MP0002638_abnormal_pupillary_reflex	0.76248204
91	MP0002933_joint_inflammation	0.75280511
92	MP0006276_abnormal_autonomic_nervous	0.74820792
93	MP0005167_abnormal_blood-brain_barrier	0.72068529
94	MP0004043_abnormal_pH_regulation	0.71224910
95	MP0005332_abnormal_amino_acid	0.71175797
96	MP0010386_abnormal_urinary_bladder	0.70599062
97	MP0002019_abnormal_tumor_incidence	0.70347721
98	MP0002272_abnormal_nervous_system	0.70267114
99	MP0003693_abnormal_embryo_hatching	0.69343757
100	MP0001119_abnormal_female_reproductive	0.68083340

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	3.97593633
2	Mitochondrial inheritance (HP:0001427)	3.85883038
3	Increased hepatocellular lipid droplets (HP:0006565)	3.75583245
4	IgG deficiency (HP:0004315)	3.74502041
5	Increased CSF lactate (HP:0002490)	3.61653072
6	Lipid accumulation in hepatocytes (HP:0006561)	3.59939136
7	3-Methylglutaconic aciduria (HP:0003535)	3.56617658
8	Abnormal mitochondria in muscle tissue (HP:0008316)	3.53441439
9	Acute encephalopathy (HP:0006846)	3.48312550
10	Congenital stationary night blindness (HP:0007642)	3.40948045
11	Hepatocellular necrosis (HP:0001404)	3.38119341
12	Progressive macrocephaly (HP:0004481)	3.35208711
13	Elevated erythrocyte sedimentation rate (HP:0003565)	3.19321178
14	Hepatic necrosis (HP:0002605)	3.16977656
15	Hypoproteinemia (HP:0003075)	3.12843920
16	Stomatitis (HP:0010280)	3.10524815
17	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.09317257
18	Methylmalonic acidemia (HP:0002912)	2.99272805
19	Abnormality of T cell number (HP:0011839)	2.97223869
20	Increased intramyocellular lipid droplets (HP:0012240)	2.96250786
21	Autoimmune hemolytic anemia (HP:0001890)	2.91765076
22	Pancreatic cysts (HP:0001737)	2.91216092
23	Renal Fanconi syndrome (HP:0001994)	2.90513708
24	Increased IgM level (HP:0003496)	2.88451742
25	Severe combined immunodeficiency (HP:0004430)	2.84542859
26	Aplastic anemia (HP:0001915)	2.80538514
27	Abolished electroretinogram (ERG) (HP:0000550)	2.78108421
28	Increased serum lactate (HP:0002151)	2.77810997
29	T lymphocytopenia (HP:0005403)	2.77402664
30	Abnormal rod and cone electroretinograms (HP:0008323)	2.76737449
31	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.69062373
32	Cerebral edema (HP:0002181)	2.62122714
33	Exertional dyspnea (HP:0002875)	2.60184409
34	Attenuation of retinal blood vessels (HP:0007843)	2.59259242
35	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.56682333
36	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.56414448
37	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.56414448
38	Optic disc pallor (HP:0000543)	2.56246168
39	Abnormality of T cells (HP:0002843)	2.54345369
40	Lactic acidosis (HP:0003128)	2.49081537
41	Methylmalonic aciduria (HP:0012120)	2.48452920
42	Increased muscle lipid content (HP:0009058)	2.47796827
43	Decreased central vision (HP:0007663)	2.47346546
44	Abnormality of the prostate (HP:0008775)	2.47034464
45	Abnormality of the renal cortex (HP:0011035)	2.45482203
46	Renal cortical cysts (HP:0000803)	2.42527659
47	True hermaphroditism (HP:0010459)	2.40909740
48	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.40888168
49	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.40142090
50	Abnormality of alanine metabolism (HP:0010916)	2.40142090
51	Hyperalaninemia (HP:0003348)	2.40142090
52	Abnormality of B cell number (HP:0010975)	2.36097991
53	Pancreatic fibrosis (HP:0100732)	2.34692426
54	Thyroiditis (HP:0100646)	2.34645089
55	Abnormality of eosinophils (HP:0001879)	2.23833538
56	Pendular nystagmus (HP:0012043)	2.20817868
57	Constricted visual fields (HP:0001133)	2.16027458
58	Abnormality of midbrain morphology (HP:0002418)	2.15262806
59	Molar tooth sign on MRI (HP:0002419)	2.15262806
60	Autoimmune thrombocytopenia (HP:0001973)	2.12973413
61	Pancytopenia (HP:0001876)	2.12167661
62	Nephronophthisis (HP:0000090)	2.11784795
63	Abnormality of T cell physiology (HP:0011840)	2.09566164
64	Lethargy (HP:0001254)	2.09173334
65	Increased corneal curvature (HP:0100692)	2.08578168
66	Keratoconus (HP:0000563)	2.08578168
67	Combined immunodeficiency (HP:0005387)	2.08558517
68	Congenital, generalized hypertrichosis (HP:0004540)	2.08178559
69	Glycosuria (HP:0003076)	2.05360719
70	Abnormality of urine glucose concentration (HP:0011016)	2.05360719
71	Eosinophilia (HP:0001880)	2.02008575
72	Testicular atrophy (HP:0000029)	1.99063881
73	Hyperglycinemia (HP:0002154)	1.98511169
74	Respiratory failure (HP:0002878)	1.96293144
75	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.94618227
76	Dicarboxylic aciduria (HP:0003215)	1.94551075
77	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.94551075
78	Aplasia/hypoplasia of the uterus (HP:0008684)	1.90940226
79	Type I transferrin isoform profile (HP:0003642)	1.89730834
80	Medial flaring of the eyebrow (HP:0010747)	1.86615789
81	Abnormal albumin level (HP:0012116)	1.85996010
82	Hypoalbuminemia (HP:0003073)	1.85996010
83	Abnormal number of erythroid precursors (HP:0012131)	1.85406987
84	Abnormality of the renal medulla (HP:0100957)	1.83995539
85	Exercise intolerance (HP:0003546)	1.83967861
86	Generalized aminoaciduria (HP:0002909)	1.83647885
87	Abnormality of serum amino acid levels (HP:0003112)	1.82442754
88	Panhypogammaglobulinemia (HP:0003139)	1.82433725
89	Chronic diarrhea (HP:0002028)	1.81703242
90	Ketosis (HP:0001946)	1.81196323
91	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.81059508
92	Abnormality of renal resorption (HP:0011038)	1.80874576
93	Type II lissencephaly (HP:0007260)	1.78996960
94	Prostate neoplasm (HP:0100787)	1.78495937
95	B lymphocytopenia (HP:0010976)	1.77702851
96	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.77229779
97	Abnormal protein N-linked glycosylation (HP:0012347)	1.77229779
98	Abnormal protein glycosylation (HP:0012346)	1.77229779
99	Abnormal glycosylation (HP:0012345)	1.77229779
100	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.77205213

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	4.10521793
2	TLK1	3.37060037
3	ZAK	3.21278800
4	VRK2	2.80979715
5	TAOK3	2.76360852
6	KDR	2.47613967
7	ADRBK2	2.45518141
8	NUAK1	2.45000870
9	MAP4K2	2.35453211
10	MST4	2.10556245
11	BCKDK	1.96245294
12	GRK1	1.96055160
13	FRK	1.86540924
14	VRK1	1.85867539
15	PASK	1.83137779
16	TESK2	1.81831354
17	MAP4K1	1.75806708
18	EIF2AK3	1.75665529
19	TIE1	1.72294917
20	MAP3K12	1.66902855
21	WNK4	1.62738083
22	TEC	1.59898772
23	PINK1	1.58644756
24	SCYL2	1.55835491
25	BUB1	1.53766610
26	ITK	1.51610291
27	BMPR1B	1.46413033
28	BMPR2	1.33246896
29	FES	1.19249510
30	GRK6	1.12284729
31	IKBKB	1.12085597
32	OXSR1	1.07713478
33	WNK3	1.07674871
34	STK16	1.06770436
35	CAMKK2	1.05690250
36	CDK19	1.05082083
37	SRPK1	1.04625365
38	SYK	1.04528118
39	KIT	1.00879720
40	MAP2K6	0.95809639
41	STK39	0.95695157
42	NME2	0.94770247
43	CSNK1G3	0.94537355
44	PBK	0.94485641
45	TRIM28	0.91173028
46	INSRR	0.90480587
47	RPS6KA5	0.89152994
48	DAPK1	0.87880655
49	TSSK6	0.87537513
50	NEK1	0.85332266
51	MYLK	0.85129699
52	MUSK	0.82482237
53	PRKCQ	0.81195002
54	ERBB3	0.80183941
55	PLK3	0.79608718
56	PHKG1	0.78814604
57	PHKG2	0.78814604
58	MAPKAPK3	0.77338060
59	IKBKE	0.76063138
60	CSNK1G1	0.76044360
61	BTK	0.72852953
62	LCK	0.72248849
63	CSNK1G2	0.71922308
64	DYRK2	0.71173438
65	PLK4	0.68912955
66	CSNK1A1L	0.64123155
67	CSF1R	0.62370133
68	MKNK1	0.62188478
69	TGFBR1	0.59476643
70	LYN	0.58105620
71	GRK7	0.57801144
72	NME1	0.56583641
73	ACVR1B	0.56191871
74	ADRBK1	0.56176818
75	EIF2AK2	0.55321524
76	LIMK1	0.52625156
77	JAK3	0.52354209
78	BRSK2	0.52293400
79	PIK3CG	0.51840039
80	PLK2	0.48673788
81	TRPM7	0.47360161
82	IGF1R	0.46398187
83	BCR	0.46294089
84	DAPK2	0.46169038
85	OBSCN	0.44858416
86	ZAP70	0.44469661
87	RPS6KA4	0.44167234
88	EIF2AK1	0.44142696
89	TAF1	0.43140082
90	CDK8	0.41916294
91	PLK1	0.38054435
92	PIM1	0.37923070
93	GRK5	0.37037340
94	PRKCE	0.36603744
95	CSNK2A1	0.36507172
96	MAPK13	0.36130893
97	RIPK4	0.35887624
98	MAPKAPK5	0.35106766
99	ATR	0.34774266
100	MAP3K14	0.34184987

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.28322084
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.19707846
3	Primary immunodeficiency_Homo sapiens_hsa05340	2.98103376
4	Ribosome_Homo sapiens_hsa03010	2.83295208
5	Allograft rejection_Homo sapiens_hsa05330	2.82722847
6	Graft-versus-host disease_Homo sapiens_hsa05332	2.80466644
7	Asthma_Homo sapiens_hsa05310	2.77310707
8	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.73956307
9	Parkinsons disease_Homo sapiens_hsa05012	2.53988269
10	Type I diabetes mellitus_Homo sapiens_hsa04940	2.36322826
11	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.27194385
12	Protein export_Homo sapiens_hsa03060	2.26207842
13	Antigen processing and presentation_Homo sapiens_hsa04612	2.13637053
14	RNA polymerase_Homo sapiens_hsa03020	2.11449455
15	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.74442067
16	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.66712294
17	Alzheimers disease_Homo sapiens_hsa05010	1.66379684
18	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.65944568
19	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.63672087
20	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.61317560
21	Homologous recombination_Homo sapiens_hsa03440	1.55842081
22	Huntingtons disease_Homo sapiens_hsa05016	1.51186118
23	Nitrogen metabolism_Homo sapiens_hsa00910	1.49806845
24	RNA degradation_Homo sapiens_hsa03018	1.46145026
25	Phototransduction_Homo sapiens_hsa04744	1.45834433
26	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.43268403
27	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.41566365
28	One carbon pool by folate_Homo sapiens_hsa00670	1.35674596
29	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.34762479
30	Rheumatoid arthritis_Homo sapiens_hsa05323	1.30420698
31	Basal transcription factors_Homo sapiens_hsa03022	1.25855778
32	Linoleic acid metabolism_Homo sapiens_hsa00591	1.24863155
33	Propanoate metabolism_Homo sapiens_hsa00640	1.17090923
34	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.14250544
35	Cardiac muscle contraction_Homo sapiens_hsa04260	1.12914624
36	Pyrimidine metabolism_Homo sapiens_hsa00240	1.12348736
37	Fanconi anemia pathway_Homo sapiens_hsa03460	1.11597026
38	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.06276549
39	Mismatch repair_Homo sapiens_hsa03430	1.05742428
40	Peroxisome_Homo sapiens_hsa04146	1.03657948
41	Caffeine metabolism_Homo sapiens_hsa00232	1.02745246
42	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.02604378
43	Sulfur metabolism_Homo sapiens_hsa00920	0.99168058
44	Spliceosome_Homo sapiens_hsa03040	0.99034513
45	Nucleotide excision repair_Homo sapiens_hsa03420	0.98193697
46	DNA replication_Homo sapiens_hsa03030	0.96027865
47	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.95402879
48	Purine metabolism_Homo sapiens_hsa00230	0.95396046
49	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.92536854
50	RNA transport_Homo sapiens_hsa03013	0.92532816
51	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.90618163
52	Butanoate metabolism_Homo sapiens_hsa00650	0.83939373
53	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.81925168
54	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.80800424
55	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.79341017
56	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.76194331
57	Selenocompound metabolism_Homo sapiens_hsa00450	0.74792591
58	Chemical carcinogenesis_Homo sapiens_hsa05204	0.74148497
59	Regulation of autophagy_Homo sapiens_hsa04140	0.73780932
60	Viral myocarditis_Homo sapiens_hsa05416	0.72869091
61	Non-homologous end-joining_Homo sapiens_hsa03450	0.70797160
62	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.69708857
63	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.69632474
64	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.68795765
65	Base excision repair_Homo sapiens_hsa03410	0.68781063
66	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.68348666
67	Collecting duct acid secretion_Homo sapiens_hsa04966	0.66943244
68	Ether lipid metabolism_Homo sapiens_hsa00565	0.66931771
69	Tryptophan metabolism_Homo sapiens_hsa00380	0.64729526
70	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.63591495
71	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.62036347
72	Retinol metabolism_Homo sapiens_hsa00830	0.61621117
73	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.57272591
74	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.57054336
75	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.56854727
76	Metabolic pathways_Homo sapiens_hsa01100	0.55481751
77	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.55242014
78	Olfactory transduction_Homo sapiens_hsa04740	0.52576700
79	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.50442062
80	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.50315633
81	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.49764986
82	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.45560407
83	Measles_Homo sapiens_hsa05162	0.45420445
84	Glutathione metabolism_Homo sapiens_hsa00480	0.44341335
85	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.42858176
86	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.42483493
87	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.42073962
88	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.40998208
89	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.40976198
90	Herpes simplex infection_Homo sapiens_hsa05168	0.39022018
91	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.38004279
92	Leishmaniasis_Homo sapiens_hsa05140	0.34742524
93	Fat digestion and absorption_Homo sapiens_hsa04975	0.33784584
94	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.33503624
95	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.31920037
96	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.31617245
97	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.27121370
98	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.26902787
99	Taste transduction_Homo sapiens_hsa04742	0.26499924
100	Salivary secretion_Homo sapiens_hsa04970	0.26188585

EEF1A1P16

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »