EEF1A1P17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.79552875
2water-soluble vitamin biosynthetic process (GO:0042364)4.45464153
3energy coupled proton transport, down electrochemical gradient (GO:0015985)4.23412173
4ATP synthesis coupled proton transport (GO:0015986)4.23412173
5mitochondrial respiratory chain complex I assembly (GO:0032981)4.18745023
6NADH dehydrogenase complex assembly (GO:0010257)4.18745023
7mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.18745023
8regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.15826203
9proteasome assembly (GO:0043248)4.09520614
10protein complex biogenesis (GO:0070271)4.07544655
11ribosomal small subunit assembly (GO:0000028)3.95910723
12cullin deneddylation (GO:0010388)3.83744169
13establishment of protein localization to mitochondrial membrane (GO:0090151)3.82625225
14mitochondrial respiratory chain complex assembly (GO:0033108)3.81410213
15tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.77061551
16RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.77061551
17protein deneddylation (GO:0000338)3.76408292
18positive regulation of defense response to virus by host (GO:0002230)3.69024371
19mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.68681407
20positive regulation of prostaglandin secretion (GO:0032308)3.67623835
21maturation of SSU-rRNA (GO:0030490)3.52273460
22response to gravity (GO:0009629)3.48718345
23GTP biosynthetic process (GO:0006183)3.47927954
24transcription elongation from RNA polymerase III promoter (GO:0006385)3.47710864
25termination of RNA polymerase III transcription (GO:0006386)3.47710864
26nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.46064337
27behavioral response to nicotine (GO:0035095)3.40053792
28pseudouridine synthesis (GO:0001522)3.39344658
29protein-cofactor linkage (GO:0018065)3.34752828
30regulation of immunoglobulin secretion (GO:0051023)3.34545998
31exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.33989215
32rRNA modification (GO:0000154)3.30656208
33negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.30001777
34protein neddylation (GO:0045116)3.28875088
35ribosomal large subunit biogenesis (GO:0042273)3.27041139
36positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.25104276
37cytidine metabolic process (GO:0046087)3.20779667
38cytidine catabolic process (GO:0006216)3.20779667
39cytidine deamination (GO:0009972)3.20779667
40maturation of 5.8S rRNA (GO:0000460)3.19803337
41fucose catabolic process (GO:0019317)3.13879568
42L-fucose metabolic process (GO:0042354)3.13879568
43L-fucose catabolic process (GO:0042355)3.13879568
44mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.13613027
45chaperone-mediated protein transport (GO:0072321)3.10186892
46regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.03153220
47ubiquinone biosynthetic process (GO:0006744)3.03100188
48viral transcription (GO:0019083)3.00899305
49tRNA processing (GO:0008033)2.99973170
50negative regulation of telomere maintenance (GO:0032205)2.98531213
51UTP biosynthetic process (GO:0006228)2.91994552
52cellular component biogenesis (GO:0044085)2.91503987
53regulation of cellular amino acid metabolic process (GO:0006521)2.91199719
54mannosylation (GO:0097502)2.90800384
55translation (GO:0006412)2.90618528
56regulation of prostaglandin secretion (GO:0032306)2.90417752
57translational elongation (GO:0006414)2.89640158
58positive regulation of fatty acid transport (GO:2000193)2.88604301
59rRNA metabolic process (GO:0016072)2.87147892
60L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.86962814
61translational termination (GO:0006415)2.86660041
62rRNA processing (GO:0006364)2.86108788
63piRNA metabolic process (GO:0034587)2.85134655
64SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.85105584
65regulation of mitotic spindle checkpoint (GO:1903504)2.84585847
66regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.84585847
67detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.83794655
68UTP metabolic process (GO:0046051)2.82644285
69respiratory chain complex IV assembly (GO:0008535)2.82148278
70regulation of chronic inflammatory response (GO:0002676)2.81798081
71preassembly of GPI anchor in ER membrane (GO:0016254)2.80724290
72cotranslational protein targeting to membrane (GO:0006613)2.79013432
73protein polyglutamylation (GO:0018095)2.78638015
74regulation of regulatory T cell differentiation (GO:0045589)2.78274855
75negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.77995985
76DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.77498870
77protein targeting to ER (GO:0045047)2.77374733
78rRNA catabolic process (GO:0016075)2.75574835
79positive regulation of icosanoid secretion (GO:0032305)2.74282179
80purine nucleoside triphosphate biosynthetic process (GO:0009145)2.70762004
81signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.69558838
82signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.69558838
83signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.69558838
84somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.69369869
85isotype switching (GO:0045190)2.69369869
86somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.69369869
87RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.68851186
88protein localization to endoplasmic reticulum (GO:0070972)2.67548589
89ubiquinone metabolic process (GO:0006743)2.66974311
90ribosome biogenesis (GO:0042254)2.65985626
91purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.65059669
92intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.64884750
93signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.64884750
94electron transport chain (GO:0022900)2.64229802
95ribonucleoprotein complex biogenesis (GO:0022613)2.63297242
96establishment of protein localization to endoplasmic reticulum (GO:0072599)2.62378617
97response to interferon-beta (GO:0035456)2.62309810
98respiratory electron transport chain (GO:0022904)2.59518667
99positive regulation of T cell mediated cytotoxicity (GO:0001916)2.59120753
100signal transduction involved in DNA integrity checkpoint (GO:0072401)2.58964883

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human4.53144065
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.36373365
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.07200531
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.74635758
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.38114637
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.29317954
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.25422714
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.18684983
9VDR_22108803_ChIP-Seq_LS180_Human3.07662782
10ZNF274_21170338_ChIP-Seq_K562_Hela2.93783965
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.85952484
12VDR_23849224_ChIP-Seq_CD4+_Human2.76964554
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.55677598
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.48653438
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.38967735
16NOTCH1_21737748_ChIP-Seq_TLL_Human2.32113080
17ELK1_19687146_ChIP-ChIP_HELA_Human2.22191622
18SRF_21415370_ChIP-Seq_HL-1_Mouse2.18020657
19FOXP3_21729870_ChIP-Seq_TREG_Human2.12709312
20MYC_18940864_ChIP-ChIP_HL60_Human2.01814232
21CREB1_15753290_ChIP-ChIP_HEK293T_Human1.95390691
22TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.88005251
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.86198616
24PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.83021971
25MYC_18555785_ChIP-Seq_MESCs_Mouse1.73348151
26TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71643609
27EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.67619832
28EWS_26573619_Chip-Seq_HEK293_Human1.65984712
29IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.60760316
30IRF8_22096565_ChIP-ChIP_GC-B_Human1.59232273
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.58808764
32MYC_18358816_ChIP-ChIP_MESCs_Mouse1.58267545
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.58066128
34YY1_21170310_ChIP-Seq_MESCs_Mouse1.54591408
35TP53_22573176_ChIP-Seq_HFKS_Human1.51830936
36IRF1_19129219_ChIP-ChIP_H3396_Human1.42417692
37TTF2_22483619_ChIP-Seq_HELA_Human1.40616560
38FUS_26573619_Chip-Seq_HEK293_Human1.39033844
39GABP_19822575_ChIP-Seq_HepG2_Human1.38231978
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.37711573
41DCP1A_22483619_ChIP-Seq_HELA_Human1.33400907
42IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.30640204
43AUTS2_25519132_ChIP-Seq_293T-REX_Human1.30577369
44PADI4_21655091_ChIP-ChIP_MCF-7_Human1.29950039
45FOXA1_27270436_Chip-Seq_PROSTATE_Human1.29848807
46FOXA1_25329375_ChIP-Seq_VCAP_Human1.29848807
47CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.28015456
48ZFP57_27257070_Chip-Seq_ESCs_Mouse1.26233597
49POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.25858183
50PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25028818
51AR_20517297_ChIP-Seq_VCAP_Human1.24539394
52ELK1_22589737_ChIP-Seq_MCF10A_Human1.23512920
53HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.23423757
54CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.22374529
55GATA3_26560356_Chip-Seq_TH2_Human1.21516046
56MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19900697
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.17315287
58ER_23166858_ChIP-Seq_MCF-7_Human1.15260853
59HOXB4_20404135_ChIP-ChIP_EML_Mouse1.14903145
60PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.10258987
61P300_19829295_ChIP-Seq_ESCs_Human1.10256030
62EGR1_23403033_ChIP-Seq_LIVER_Mouse1.10114017
63SOX2_19829295_ChIP-Seq_ESCs_Human1.09811171
64NANOG_19829295_ChIP-Seq_ESCs_Human1.09811171
65CIITA_25753668_ChIP-Seq_RAJI_Human1.09640674
66MYC_19030024_ChIP-ChIP_MESCs_Mouse1.09599924
67GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08422665
68EZH2_22144423_ChIP-Seq_EOC_Human1.07702074
69NCOR_22424771_ChIP-Seq_293T_Human1.07581181
70XRN2_22483619_ChIP-Seq_HELA_Human1.07578657
71PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07570451
72CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.07131650
73ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.05635784
74EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.04979304
75CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.04157813
76PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.04081037
77FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.04034128
78FOXH1_21741376_ChIP-Seq_EPCs_Human1.03103344
79NANOG_20526341_ChIP-Seq_ESCs_Human1.01460167
80CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.01408986
81HOXB7_26014856_ChIP-Seq_BT474_Human1.00844595
82SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.00594835
83GATA3_21878914_ChIP-Seq_MCF-7_Human1.00353136
84MYC_19829295_ChIP-Seq_ESCs_Human0.98824466
85E2F1_18555785_ChIP-Seq_MESCs_Mouse0.98252647
86CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.97428855
87TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.97041707
88CTBP2_25329375_ChIP-Seq_LNCAP_Human0.96777925
89RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.96646611
90FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95798856
91TAF15_26573619_Chip-Seq_HEK293_Human0.95483794
92GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95401494
93EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.94759499
94CBP_20019798_ChIP-Seq_JUKART_Human0.94521809
95IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.94521809
96THAP11_20581084_ChIP-Seq_MESCs_Mouse0.92736551
97E2F4_17652178_ChIP-ChIP_JURKAT_Human0.91995210
98TAF2_19829295_ChIP-Seq_ESCs_Human0.91411184
99POU3F2_20337985_ChIP-ChIP_501MEL_Human0.88249087
100ERA_21632823_ChIP-Seq_H3396_Human0.86497795

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002138_abnormal_hepatobiliary_system3.08361905
2MP0002102_abnormal_ear_morphology2.93927268
3MP0005671_abnormal_response_to2.92014121
4MP0004147_increased_porphyrin_level2.66832399
5MP0004885_abnormal_endolymph2.65272186
6MP0008875_abnormal_xenobiotic_pharmacok2.64491248
7MP0008877_abnormal_DNA_methylation2.45930543
8MP0001968_abnormal_touch/_nociception2.40440070
9MP0001835_abnormal_antigen_presentation2.36989531
10MP0006072_abnormal_retinal_apoptosis2.32848155
11MP0002163_abnormal_gland_morphology2.21513366
12MP0004145_abnormal_muscle_electrophysio2.10153630
13MP0008872_abnormal_physiological_respon2.06042963
14MP0006292_abnormal_olfactory_placode2.04192538
15MP0002876_abnormal_thyroid_physiology2.02145873
16MP0002148_abnormal_hypersensitivity_rea1.96483275
17MP0002736_abnormal_nociception_after1.95036237
18MP0002837_dystrophic_cardiac_calcinosis1.93910075
19MP0000372_irregular_coat_pigmentation1.93002110
20MP0005084_abnormal_gallbladder_morpholo1.89805085
21MP0000685_abnormal_immune_system1.87264727
22MP0005645_abnormal_hypothalamus_physiol1.87140644
23MP0008058_abnormal_DNA_repair1.82138719
24MP0003786_premature_aging1.82072231
25MP0000569_abnormal_digit_pigmentation1.72830323
26MP0005646_abnormal_pituitary_gland1.68669491
27MP0003718_maternal_effect1.63710033
28MP0004142_abnormal_muscle_tone1.59074768
29MP0003646_muscle_fatigue1.53495924
30MP0005360_urolithiasis1.45877708
31MP0003806_abnormal_nucleotide_metabolis1.43688771
32MP0005551_abnormal_eye_electrophysiolog1.42866864
33MP0005379_endocrine/exocrine_gland_phen1.40805228
34MP0002277_abnormal_respiratory_mucosa1.38053684
35MP0001905_abnormal_dopamine_level1.31397115
36MP0001986_abnormal_taste_sensitivity1.30637986
37MP0004742_abnormal_vestibular_system1.28349974
38MP0003195_calcinosis1.25975083
39MP0005253_abnormal_eye_physiology1.24167990
40MP0005387_immune_system_phenotype1.24056689
41MP0001790_abnormal_immune_system1.24056689
42MP0001800_abnormal_humoral_immune1.23850850
43MP0002938_white_spotting1.22531602
44MP0005075_abnormal_melanosome_morpholog1.21420692
45MP0003866_abnormal_defecation1.18023930
46MP0001529_abnormal_vocalization1.18021953
47MP0001501_abnormal_sleep_pattern1.17029086
48MP0009764_decreased_sensitivity_to1.16523607
49MP0005000_abnormal_immune_tolerance1.16309451
50MP0005410_abnormal_fertilization1.16008009
51MP0009333_abnormal_splenocyte_physiolog1.14981557
52MP0002723_abnormal_immune_serum1.14627971
53MP0008775_abnormal_heart_ventricle1.13803622
54MP0003186_abnormal_redox_activity1.13188705
55MP0000427_abnormal_hair_cycle1.11845330
56MP0006035_abnormal_mitochondrial_morpho1.10012516
57MP0009785_altered_susceptibility_to1.09789131
58MP0005085_abnormal_gallbladder_physiolo1.09418565
59MP0003878_abnormal_ear_physiology1.06951954
60MP0005377_hearing/vestibular/ear_phenot1.06951954
61MP0002006_tumorigenesis1.06126666
62MP0002272_abnormal_nervous_system1.05012653
63MP0003436_decreased_susceptibility_to1.01309677
64MP0005636_abnormal_mineral_homeostasis0.99624568
65MP0002234_abnormal_pharynx_morphology0.98539289
66MP0002095_abnormal_skin_pigmentation0.97137959
67MP0005389_reproductive_system_phenotype0.96561633
68MP0008789_abnormal_olfactory_epithelium0.96092594
69MP0006276_abnormal_autonomic_nervous0.94569849
70MP0000647_abnormal_sebaceous_gland0.94016927
71MP0002452_abnormal_antigen_presenting0.93277326
72MP0006036_abnormal_mitochondrial_physio0.93201744
73MP0000613_abnormal_salivary_gland0.93175668
74MP0003880_abnormal_central_pattern0.92135916
75MP0003011_delayed_dark_adaptation0.91412895
76MP0003724_increased_susceptibility_to0.90493119
77MP0001542_abnormal_bone_strength0.89621657
78MP0001819_abnormal_immune_cell0.89103793
79MP0002420_abnormal_adaptive_immunity0.88647100
80MP0001440_abnormal_grooming_behavior0.87885624
81MP0001293_anophthalmia0.86953559
82MP0009745_abnormal_behavioral_response0.86473871
83MP0003763_abnormal_thymus_physiology0.86061995
84MP0001764_abnormal_homeostasis0.83872636
85MP0001873_stomach_inflammation0.82296301
86MP0002166_altered_tumor_susceptibility0.79905032
87MP0001485_abnormal_pinna_reflex0.79316737
88MP0001765_abnormal_ion_homeostasis0.79077238
89MP0005332_abnormal_amino_acid0.77014895
90MP0002160_abnormal_reproductive_system0.76981353
91MP0000049_abnormal_middle_ear0.74579552
92MP0002210_abnormal_sex_determination0.74504423
93MP0002693_abnormal_pancreas_physiology0.73136648
94MP0001845_abnormal_inflammatory_respons0.71794839
95MP0003638_abnormal_response/metabolism_0.71449369
96MP0000689_abnormal_spleen_morphology0.70657322
97MP0002751_abnormal_autonomic_nervous0.70454854
98MP0001929_abnormal_gametogenesis0.67602753
99MP0010155_abnormal_intestine_physiology0.66818697
100MP0003693_abnormal_embryo_hatching0.65556911

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)3.92702607
2Mitochondrial inheritance (HP:0001427)3.65423990
3Pancreatic cysts (HP:0001737)3.57112423
4IgG deficiency (HP:0004315)3.55661572
53-Methylglutaconic aciduria (HP:0003535)3.51537563
6Increased CSF lactate (HP:0002490)3.49545834
7Abnormal mitochondria in muscle tissue (HP:0008316)3.42560348
8Acute encephalopathy (HP:0006846)3.41860839
9Progressive macrocephaly (HP:0004481)3.27982197
10Hepatocellular necrosis (HP:0001404)3.24866354
11Abnormality of the renal cortex (HP:0011035)3.19424684
12Pancreatic fibrosis (HP:0100732)3.17082680
13Hepatic necrosis (HP:0002605)3.16841426
14Congenital stationary night blindness (HP:0007642)3.12410739
15Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.12249004
16Abnormality of alanine metabolism (HP:0010916)3.12249004
17Hyperalaninemia (HP:0003348)3.12249004
18Abnormality of midbrain morphology (HP:0002418)3.08350100
19Molar tooth sign on MRI (HP:0002419)3.08350100
20Type II lissencephaly (HP:0007260)3.02217904
21Methylmalonic acidemia (HP:0002912)2.93882309
22Increased serum lactate (HP:0002151)2.93349030
23True hermaphroditism (HP:0010459)2.91760818
24Renal cortical cysts (HP:0000803)2.88553279
25Congenital, generalized hypertrichosis (HP:0004540)2.84739678
26Nephronophthisis (HP:0000090)2.79873818
27Abolished electroretinogram (ERG) (HP:0000550)2.79865755
28Aplasia/hypoplasia of the uterus (HP:0008684)2.77936305
29Increased hepatocellular lipid droplets (HP:0006565)2.76624900
30Hypoplasia of the uterus (HP:0000013)2.73473429
31Methylmalonic aciduria (HP:0012120)2.71242629
32Optic disc pallor (HP:0000543)2.57074987
33Lipid accumulation in hepatocytes (HP:0006561)2.56830301
34Elevated erythrocyte sedimentation rate (HP:0003565)2.56495833
35Cerebral edema (HP:0002181)2.56136674
36Type I transferrin isoform profile (HP:0003642)2.55170146
37Lactic acidosis (HP:0003128)2.53181848
38Prostate neoplasm (HP:0100787)2.52635999
39Abnormal number of erythroid precursors (HP:0012131)2.51971075
40Abnormality of the renal medulla (HP:0100957)2.51615459
41Stomatitis (HP:0010280)2.51245406
42Absent rod-and cone-mediated responses on ERG (HP:0007688)2.48605817
43Abnormality of cells of the erythroid lineage (HP:0012130)2.42878268
44Abnormality of the prostate (HP:0008775)2.40133336
45Abnormal rod and cone electroretinograms (HP:0008323)2.36728537
46Decreased activity of mitochondrial respiratory chain (HP:0008972)2.30611980
47Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.30611980
48Abnormality of the pons (HP:0007361)2.24806816
49Decreased electroretinogram (ERG) amplitude (HP:0000654)2.22389410
50Aplasia/Hypoplasia of the spleen (HP:0010451)2.15519949
51Renal Fanconi syndrome (HP:0001994)2.14232239
52Pancytopenia (HP:0001876)2.12620473
53Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.11012479
54Pendular nystagmus (HP:0012043)2.09934807
55Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.09922392
56Abnormal protein N-linked glycosylation (HP:0012347)2.09922392
57Abnormal protein glycosylation (HP:0012346)2.09922392
58Abnormal glycosylation (HP:0012345)2.09922392
59Tongue fasciculations (HP:0001308)2.09269688
60Hypoplasia of the pons (HP:0012110)2.08791247
61Reduced antithrombin III activity (HP:0001976)2.07196515
62Lethargy (HP:0001254)2.05495082
63Respiratory failure (HP:0002878)2.04334982
64Sclerocornea (HP:0000647)2.01714318
65Asplenia (HP:0001746)2.01228102
66Adrenal hypoplasia (HP:0000835)2.01111783
67Delayed CNS myelination (HP:0002188)2.00268552
68Abnormality of T cell physiology (HP:0011840)1.99595846
69Reticulocytopenia (HP:0001896)1.98940937
70Hypoproteinemia (HP:0003075)1.98408370
71Short tibia (HP:0005736)1.98324146
72Increased intramyocellular lipid droplets (HP:0012240)1.96984211
73Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.96296779
74Exertional dyspnea (HP:0002875)1.91846290
75Constricted visual fields (HP:0001133)1.90815642
76Hypokalemic alkalosis (HP:0001949)1.90593624
77Abnormality of the vitamin B12 metabolism (HP:0004341)1.88972092
78Attenuation of retinal blood vessels (HP:0007843)1.88639079
79Medial flaring of the eyebrow (HP:0010747)1.88069138
80Severe combined immunodeficiency (HP:0004430)1.87597060
81Polyuria (HP:0000103)1.85952078
82Testicular atrophy (HP:0000029)1.85164196
83Keratoconus (HP:0000563)1.84717102
84Increased corneal curvature (HP:0100692)1.84717102
85Large for gestational age (HP:0001520)1.83746744
86Abnormality of vitamin B metabolism (HP:0004340)1.82539938
87Abnormality of T cells (HP:0002843)1.82396953
88Exercise intolerance (HP:0003546)1.82016480
89Cystic liver disease (HP:0006706)1.80227846
90Glycosuria (HP:0003076)1.79912584
91Abnormality of urine glucose concentration (HP:0011016)1.79912584
92Hypothermia (HP:0002045)1.78355388
93Type 2 muscle fiber atrophy (HP:0003554)1.78133334
94Colon cancer (HP:0003003)1.76394607
95Aplasia/Hypoplasia of the tibia (HP:0005772)1.75763163
96Polydipsia (HP:0001959)1.75609555
97Abnormal drinking behavior (HP:0030082)1.75609555
98Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.75576027
99Conical tooth (HP:0000698)1.75550795
100Severe muscular hypotonia (HP:0006829)1.75524895

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.89204240
2TLK13.64317077
3TXK3.61297635
4MAP4K23.50870171
5TAOK32.85090256
6ADRBK22.82376941
7NUAK12.80328760
8NME22.77658637
9ZAK2.51855199
10BCKDK2.23376115
11VRK12.01243473
12STK162.00494711
13TSSK61.97127716
14FRK1.86417789
15BUB11.75616481
16MST41.75540492
17GRK11.73149913
18BMPR1B1.66488893
19TIE11.60938855
20TAF11.59553888
21PHKG21.54978311
22PHKG11.54978311
23WNK41.45775378
24EIF2AK31.44826202
25MAPKAPK31.31458865
26SRPK11.31176032
27PLK41.25971913
28DAPK11.24657876
29NEK11.23412818
30IKBKB1.19785111
31GRK51.15538600
32TESK21.11371571
33TRIM281.11371029
34OXSR11.11055857
35LIMK11.04925113
36TGFBR11.00109431
37KIT0.98353433
38GRK70.97936253
39STK390.95999976
40CSNK1G30.95486525
41MAP2K20.93513655
42PASK0.93490669
43EIF2AK20.93451317
44INSRR0.92060300
45PLK30.91500493
46TEC0.91229956
47MAPKAPK50.91027975
48PDK20.89787934
49ITK0.87064737
50EIF2AK10.85932723
51PINK10.84894866
52GRK60.84673761
53WNK30.80928863
54CDK190.80468036
55CSNK1G10.79550056
56DYRK20.79178310
57CSNK1G20.78574743
58MKNK10.76675588
59ADRBK10.73808197
60CSNK1A1L0.72733394
61KDR0.68584311
62MAP4K10.68297276
63CAMKK20.67352027
64CDK80.67038062
65RPS6KA50.65913058
66PLK20.63922333
67MAP3K120.61151642
68MKNK20.60864748
69DAPK20.59624670
70IKBKE0.56702159
71LMTK20.55876436
72TESK10.55585077
73FES0.51505046
74MAP3K140.50879360
75TNIK0.44536763
76SYK0.44476413
77ATR0.43955262
78MAPK130.42910584
79PRKCQ0.42758581
80PRKCG0.42155388
81PRKCE0.42036874
82ERBB30.40512967
83BCR0.39931088
84ABL20.39152360
85IGF1R0.39093949
86AURKA0.38728322
87PIM20.36520799
88PRKCI0.36312188
89CSNK1A10.35241618
90CSNK2A20.34630506
91ACVR1B0.33619085
92CHEK20.33273579
93MAP2K60.32541238
94CSNK2A10.32219628
95CHUK0.32028555
96LCK0.29468135
97PRKACA0.27908392
98TBK10.27331245
99MAPK150.27061719
100DAPK30.26070407

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.67271229
2Ribosome_Homo sapiens_hsa030103.49861952
3Oxidative phosphorylation_Homo sapiens_hsa001902.99228297
4RNA polymerase_Homo sapiens_hsa030202.72530301
5Asthma_Homo sapiens_hsa053102.67855924
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.55270066
7Allograft rejection_Homo sapiens_hsa053302.36226480
8Parkinsons disease_Homo sapiens_hsa050122.34765157
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.25432005
10Protein export_Homo sapiens_hsa030602.17932666
11Autoimmune thyroid disease_Homo sapiens_hsa053202.16693551
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.02545399
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.92682776
14Graft-versus-host disease_Homo sapiens_hsa053321.90769844
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.88175951
16Type I diabetes mellitus_Homo sapiens_hsa049401.81602652
17RNA degradation_Homo sapiens_hsa030181.63601956
18Basal transcription factors_Homo sapiens_hsa030221.61025392
19Huntingtons disease_Homo sapiens_hsa050161.58385441
20Homologous recombination_Homo sapiens_hsa034401.58050711
21Antigen processing and presentation_Homo sapiens_hsa046121.57425546
22Primary immunodeficiency_Homo sapiens_hsa053401.54989919
23Linoleic acid metabolism_Homo sapiens_hsa005911.53284872
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.52724621
25Pyrimidine metabolism_Homo sapiens_hsa002401.51502769
26Sulfur metabolism_Homo sapiens_hsa009201.51373220
27Alzheimers disease_Homo sapiens_hsa050101.46810060
28Caffeine metabolism_Homo sapiens_hsa002321.46201797
29One carbon pool by folate_Homo sapiens_hsa006701.36790072
30Nitrogen metabolism_Homo sapiens_hsa009101.36369543
31Phototransduction_Homo sapiens_hsa047441.32435553
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.26359767
33RNA transport_Homo sapiens_hsa030131.25357635
34Nucleotide excision repair_Homo sapiens_hsa034201.24366305
35Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.23987227
36Fanconi anemia pathway_Homo sapiens_hsa034601.22940160
37Mismatch repair_Homo sapiens_hsa034301.21677307
38Purine metabolism_Homo sapiens_hsa002301.21151908
39Spliceosome_Homo sapiens_hsa030401.20887570
40Rheumatoid arthritis_Homo sapiens_hsa053231.19278028
41Maturity onset diabetes of the young_Homo sapiens_hsa049501.15655333
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12088961
43Cardiac muscle contraction_Homo sapiens_hsa042601.07209146
44Base excision repair_Homo sapiens_hsa034101.04595162
45Propanoate metabolism_Homo sapiens_hsa006401.03752510
46DNA replication_Homo sapiens_hsa030301.01879133
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.01162725
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.99516920
49Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.98796307
50Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.98649370
51Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.97432583
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97169186
53Arachidonic acid metabolism_Homo sapiens_hsa005900.95525044
54Tryptophan metabolism_Homo sapiens_hsa003800.92792811
55Sulfur relay system_Homo sapiens_hsa041220.92338394
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.91645822
57Non-homologous end-joining_Homo sapiens_hsa034500.90459720
58Cyanoamino acid metabolism_Homo sapiens_hsa004600.87442890
59Cysteine and methionine metabolism_Homo sapiens_hsa002700.86639295
60Peroxisome_Homo sapiens_hsa041460.85949928
61Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.81906382
62Chemical carcinogenesis_Homo sapiens_hsa052040.78415293
63NF-kappa B signaling pathway_Homo sapiens_hsa040640.77939852
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77157458
65Primary bile acid biosynthesis_Homo sapiens_hsa001200.76253992
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.70817696
67Hematopoietic cell lineage_Homo sapiens_hsa046400.68180716
68Ether lipid metabolism_Homo sapiens_hsa005650.68161023
69Fat digestion and absorption_Homo sapiens_hsa049750.66068722
70Metabolic pathways_Homo sapiens_hsa011000.64898420
71Regulation of autophagy_Homo sapiens_hsa041400.64772757
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.60359553
73Glutathione metabolism_Homo sapiens_hsa004800.55444995
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.55400046
75Selenocompound metabolism_Homo sapiens_hsa004500.55337097
76Collecting duct acid secretion_Homo sapiens_hsa049660.53736219
77Fatty acid elongation_Homo sapiens_hsa000620.53194310
78Retinol metabolism_Homo sapiens_hsa008300.52731039
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52239397
80Salivary secretion_Homo sapiens_hsa049700.52237835
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.52053376
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51571145
83Butanoate metabolism_Homo sapiens_hsa006500.46768525
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45862750
85Folate biosynthesis_Homo sapiens_hsa007900.45426985
86Systemic lupus erythematosus_Homo sapiens_hsa053220.44978408
87Epstein-Barr virus infection_Homo sapiens_hsa051690.43712133
88Taste transduction_Homo sapiens_hsa047420.41255762
89Olfactory transduction_Homo sapiens_hsa047400.40368871
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40287985
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.38560274
92Vitamin digestion and absorption_Homo sapiens_hsa049770.36161123
93RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.36080573
94Herpes simplex infection_Homo sapiens_hsa051680.35309613
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35239514
96Viral myocarditis_Homo sapiens_hsa054160.35101039
97Pyruvate metabolism_Homo sapiens_hsa006200.33288932
98NOD-like receptor signaling pathway_Homo sapiens_hsa046210.32674262
99Mineral absorption_Homo sapiens_hsa049780.30598743
100Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.30352848

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »